Dengue fever [classical dengue]

AB1_DENGUE_FEVER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A90
  • Hospital discharge: ICD-9 06[1]
  • Hospital discharge: ICD-8 06[1]
  • Cause of death: ICD-10 A90
  • Cause of death: ICD-9 06[1]
  • Cause of death: ICD-8 06[1]

2 out of 7 registries used, show all original rules.

66

4. Check minimum number of events

None

66

5. Include endpoints

None

66

6. Filter based on genotype QC (FinnGen only)

66

Control definitions (FinnGen only)

Control exclude
AB1_ARTHROPOD

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 598 263 328
Only index persons 556 246 310
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 34.94 35.30 34.62
Only index persons 34.77 34.95 34.62

-FinnGen-

Key figures

All Female Male
Number of individuals 66 36 30
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 42.30 40.95 43.91

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
62
Matched controls
620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A90
ICD-10 Finland
Dengue fever [classical dengue]
+∞
73.1
55
*
R50.9
ICD-10 Finland
Fever, unspecified
8.7
11.4
27
50
B34.9
ICD-10 Finland
Viral infection, unspecified
26.8
9.8
13
6
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.4
7.1
36
147

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
11
13
9.95
8.72
1.0
1.2
—
—
—
0
0
14
24
7.13
8.24
1.1
1.1
—
—
—
0
0
15
46
3.93
4.51
2.4
1.8
—
—
—
0
0
25
121
2.72
3.52
6.9
7.5
—
—
—
0
0
31
168
2.59
3.48
6.5
6.1
—
—
—
0
0
6
7
9.27
3.33
1.2
1.0
—
—
—
0
0
38
234
2.47
3.18
7.6
9.0
0.0
0.0
e9/l
0.00
32
190
21
101
2.58
2.94
3.4
4.0
—
—
—
0
0
6
10
6.47
2.76
1.2
1.0
—
—
—
0
0
44
302
2.37
2.73
8.6
10.7
3.1
3.9
e9/l
1.92
37
272
7
15
5.08
2.67
3.6
1.9
—
—
—
0
0
40
269
2.24
2.54
6.6
5.8
1.8
1.8
e9/l
0.15
35
243
39
262
2.19
2.45
6.7
5.8
0.5
0.6
e9/l
1.39
34
236
39
262
2.19
2.45
6.7
5.9
0.0
0.0
e9/l
0.09
34
238
29
178
2.12
2.25
3.1
3.1
5.8
15.3
e6/l
1.32
24
119
8
27
3.23
2.01
4.0
4.7
—
—
—
0
0
7
22
3.43
1.94
3.0
1.2
39.0
39.2
nmol/l
—
7
22
15
80
2.13
1.61
2.7
1.8
—
—
—
0
0
22
140
1.86
1.45
2.4
2.0
—
—
—
0
0
60
532
2.40
1.35
14.4
12.0
41.0
40.8
%
0.17
50
440
5
18
2.92
1.31
1.2
1.2
—
—
—
0
0
5
18
2.92
1.31
1.4
1.4
—
—
—
0
0
5
19
2.76
1.24
1.2
1.1
—
—
—
0
0
20
131
1.76
1.18
2.4
2.4
—
—
—
0
0
8
40
2.14
1.16
1.3
1.8
—
—
—
0
0
27
200
1.59
0.99
2.8
2.7
—
—
—
0
0
54
474
1.77
0.96
15.1
14.7
13.1
13.5
%
2.26
54
468
6
30
2.10
0.89
1.3
2.4
0.0
0.1
e6/l
—
6
30
11
66
1.80
0.85
1.6
1.4
—
—
—
0
0
9
53
1.81
0.80
8.4
8.0
1.0
1.1
mmol/l
—
9
47
42
355
1.50
0.79
3.8
3.7
—
—
—
0
0
9
58
1.64
0.73
1.4
2.5
25.7
25.6
%
—
9
47
5
27
1.92
0.70
7.6
4.5
—
—
—
0
0
5
29
1.78
0.65
1.0
1.2
—
—
—
0
0
17
224
0.68
0.64
3.1
2.5
—
—
—
0
0
0
20
0.00
0.61
0.0
2.5
—
—
—
0
0
0
20
0.00
0.61
0.0
1.7
—
70.5
—
0
20
6
35
1.78
0.59
2.0
1.9
3.0
1.1
g/l
—
6
30
9
60
1.58
0.57
1.7
2.5
2.5
2.5
g/l
—
9
52
24
192
1.39
0.56
2.1
1.8
—
—
—
0
0
15
110
1.47
0.55
2.9
3.1
—
—
—
0
0
9
64
1.47
0.54
1.7
2.6
15.5
16.2
umol/l
—
9
56
21
165
1.40
0.54
5.9
6.8
1.2
1.1
inr
—
5
52
10
140
0.66
0.50
2.0
2.4
—
—
—
0
0
16
122
1.41
0.48
1.5
1.5
1.6
2.5
g/l
1.95
11
73
7
49
1.48
0.48
1.0
1.6
—
—
—
0
0
7
49
1.48
0.48
1.7
3.3
—
—
—
0
0
8
57
1.46
0.44
1.5
1.4
—
—
—
0
0
39
346
1.31
0.44
2.6
3.3
—
—
—
0
0
8
59
1.40
0.43
1.5
1.4
—
—
—
0
0
9
65
1.44
0.41
1.6
1.8
—
—
—
0
0
15
117
1.37
0.40
1.7
1.8
—
—
—
0
0
5
36
1.42
0.39
1.4
1.3
442.8
876.0
u/ml
—
5
30
11
82
1.41
0.37
1.5
1.7
—
—
—
0
0
15
124
1.27
0.27
2.0
2.5
—
—
—
0
0
0
10
0.00
0.21
0.0
3.6
—
57.5
—
0
10
0
10
0.00
0.21
0.0
3.3
—
3.9
—
0
10
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
3.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.6
—
2.6
—
0
8
0
13
0.00
0.21
0.0
2.6
—
8.1
—
0
13
0
13
0.00
0.21
0.0
2.6
—
5.1
—
0
13
7
59
1.21
0.19
1.1
1.1
—
—
—
0
0
13
111
1.21
0.17
1.2
1.3
79.3
24.4
iu/ml
—
5
44
19
171
1.16
0.14
2.1
1.9
106.8
98.1
pmol/l
0.63
12
87
24
220
1.14
0.14
2.5
2.8
213.3
106.5
ug/l
0.54
24
200
5
43
1.18
0.10
1.0
3.8
1.1
2.0
%
—
5
38
6
57
1.06
0.09
1.3
1.4
—
—
—
0
0
12
109
1.12
0.06
1.4
1.8
0.4
1.1
mg/l
—
7
88
10
90
1.13
0.06
1.1
1.3
—
—
—
0
0
12
130
0.91
0.05
4.2
4.5
—
—
—
0
0
12
112
1.09
0.03
1.2
1.3
6.0
3.2
u/ml
—
6
41
16
166
0.95
0.00
1.7
1.6
—
—
—
0
0
13
133
0.97
0.00
3.5
3.3
—
—
—
0
0
10
95
1.06
0.00
1.7
1.6
23.6
20.7
nmol/l
—
10
84
16
162
0.98
0.00
2.6
2.6
—
—
—
0
0
17
172
0.98
0.00
4.0
3.4
25.8
18.0
ng/l
—
9
99
0
5
0.00
0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
7
77
0.90
0.00
5.6
2.3
224.6
78.0
ug/g
—
7
59
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
18.7
—
1555.7
—
0
6
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
13.6
—
0
6
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
0.2
—
0
6
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
15.5
—
829.0
—
0
6
6
66
0.90
0.00
1.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
6.0
—
—
—
0
0
59
582
1.13
0.00
10.0
11.2
—
—
—
0
0
5
52
0.96
0.00
1.2
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
92.7
—
0
7
0
9
0.00
0.00
0.0
4.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_DENGUE_FEVER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_DENGUE_FEVER.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: AB1_DENGUE_FEVER – Dengue fever [classical dengue]

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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