This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

AB1_ZOONOTIC_BACTERIAL

Leptospirosis

EFO Endpoint Browser

AB1_LEPTOSPIROSIS

No definition available.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A27 Cause of death: ICD-10 — A27 2 out of 7 registries used, show all original rules.	13
4. Check minimum number of events None	13
5. Include endpoints None	13
6. Filter based on genotype QC (FinnGen only)	13

Control definitions (FinnGen only)

Control exclude: AB1_ZOONOTIC_BACTERIAL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_LEPTOSPIROSIS
CONTROL_EXCLUDE	AB1_ZOONOTIC_BACTERIAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A27
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A27
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Leptospirosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	87	46	40
Only index persons	81	43	38
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	33.52	32.73	34.27
Only index persons	32.67	32.03	33.41

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	13	5	8
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	30.39	22.83	35.12

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

5.99

2.25

1.3

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

4.20

1.78

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

3.74

1.52

4.5

4.4

0.8

29.2

mg/mmol

—

(3044640) Blood type and Crossmatch panel - Blood

3.26

1.29

1.6

1.8

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

3.39

1.14

1.3

1.5

—

(3009508) Creatinine [Moles/volume] in Urine

2.83

1.04

2.7

3.1

11.2

9.0

mmol/l

—

(1761868) Lipid panel - Serum or Plasma

2.91

0.96

5.0

2.8

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.74

0.86

1.2

1.7

2.4

3.1

g/l

—

(42870588) Differential panel, method unspecified - Blood

2.27

0.65

1.7

5.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.05

0.62

1.9

2.7

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

2.07

0.51

5.0

1.6

53.6

52.9

u/l

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

1.99

0.46

4.0

2.6

94.7

64.6

nmol/l

—

(3032080) INR in Blood by Coagulation assay

1.99

0.46

5.7

7.6

—

1.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.44

0.0

1.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.43

0.0

1.7

—

(3044889) 12 lead EKG panel

1.59

0.25

2.6

2.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

1.46

0.24

6.6

4.3

14.4

14.5

pmol/l

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.22

0.0

1.3

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.22

0.0

1.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.31

0.12

1.4

2.1

—

(3013707) Erythrocyte sedimentation rate by Westergren method

0.83

0.11

4.1

3.2

6.7

7.1

mm/h

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3036489) Thrombin time

0.00

0.0

2.0

—

21.3

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.2

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.3

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.2

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.00

0.0

3.7

—

23.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.2

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

11.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.4

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.0

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.6

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3037467) Urinalysis macro (dipstick) panel - Urine

0.88

0.00

3.9

3.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

0.88

0.00

7.6

3.8

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

0.00

0.0

1.2

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.2

—

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.4

—

49.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.0

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.0

1.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

29.0

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.4

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.0

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.0

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.1

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.0

1.4

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

2.2

—

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.0

1.4

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.2

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.0

1.4

—

(40761536) Microorganisms panel - Urine sediment

0.00

0.0

2.7

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3022621) pH of Urine by Test strip

0.00

0.0

1.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_LEPTOSPIROSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_LEPTOSPIROSIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_LEPTOSPIROSIS – Leptospirosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Leptospirosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints