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Certain zoonotic bacterial diseases

DOID EFO Endpoint Browser PheWeb

AB1_ZOONOTIC_BACTERIAL

Yersinia pestis infectious disease: Plague is a severe bacterial infection caused by the gram-negative bacterium Yersinia pestis.

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Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — A20-A28
  • Hospital discharge: ICD-9 — 02[0-7]|B783A
  • Hospital discharge: ICD-8 — 02[0-7]
  • Cause of death: ICD-10 — A20-A28
  • Cause of death: ICD-9 — 02[0-7]|B783A
  • Cause of death: ICD-8 — 02[0-7]

2 out of 7 registries used, show all original rules.

700

4. Check minimum number of events

None

700

5. Include endpoints

700

6. Filter based on genotype QC (FinnGen only)

681

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6494 3019 3435
Only index persons 5630 2662 2968
Unadjusted period prevalence (%)
Whole population 0.09 0.09 0.10
Only index persons 0.11 0.10 0.11
Median age at first event (years)
Whole population 47.98 48.65 47.21
Only index persons 45.99 46.97 45.11

-FinnGen-

Key figures

All Female Male
Number of individuals 681 348 333
Unadjusted period prevalence (%) 0.14 0.12 0.15
Median age at first event (years) 51.06 48.67 53.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
700
Matched controls
7000
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A21.9
ICD-10 Finland
Tularaemia, unspecified
1794.4
261.7
238
*
A21.0
ICD-10 Finland
Ulceroglandular tularaemia
+∞
140.5
130
*
J01MA02
ATC
ciprofloxacin; systemic
4.2
76.3
420
1846
R50.9
ICD-10 Finland
Fever, unspecified
3.6
44.0
179
606
A21.2
ICD-10 Finland
Pulmonary tularaemia
+∞
31.5
30
*
A26.0
ICD-10 Finland
Cutaneous erysipeloid
+∞
26.2
25
*
A21.8
ICD-10 Finland
Other forms of tularaemia
+∞
23.0
22
*
A21
ICD-10 Finland
Tularaemia
+∞
16.7
16
*
0210A
ICD-9 Finland
Tularaemia, Ulceroglandular tularaemia
+∞
16.7
16
*
J17.0*A21.2
ICD-10 Finland
Pneumonia (due to)(in) tularaemia
+∞
15.7
15
*
A98.5
ICD-10 Finland
Haemorrhagic fever with renal syndrome
5.0
13.9
30
62
02100
ICD-8 Finland
Tularaemia, Glanduraris sive ulceroglandularis
+∞
13.6
13
*
0219X
ICD-9 Finland
Tularaemia, Unspecified tularaemia
+∞
13.6
13
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
13.4
80
326
A28.9
ICD-10 Finland
Zoonotic bacterial disease, unspecified
+∞
12.5
12
*
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.9
11.7
26
55
A25.1
ICD-10 Finland
Streptobacillosis
111.6
10.4
11
*
0218X
ICD-9 Finland
Tularaemia, Other specified tularaemia
+∞
10.4
10
*
A28.19
ICD-10 Finland
Other or indefinite cat-scratch fever
+∞
10.4
10
*
A21.7
ICD-10 Finland
Generalized tularaemia
+∞
10.4
10
*
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
10.4
159
944
A46
ICD-10 Finland
Erysipelas
2.1
10.1
111
586
0270X
ICD-9 Finland
Other zoonotic bacterial diseases, Listeriosis[LISTERIOSIS ALIA (EI SYNNYNNÄINEN)]
+∞
9.4
9
*
A27.9
ICD-10 Finland
Leptospirosis, unspecified
+∞
9.4
9
*
A26.9
ICD-10 Finland
Erysipeloid, unspecified
+∞
9.4
9
*
UDC00
NOMESCO Finland
Ear microscopy
2.5
9.4
62
265
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.1
9.1
87
435
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
9.1
159
980
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.3
8.3
31
97
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
8.1
115
661
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
8.0
307
2310
J01MA12
ATC
levofloxacin; systemic
1.8
8.0
133
805
SPAT1044
SPAT
Tympanometry
3.9
7.9
23
61
A28
ICD-10 Finland
Other zoonotic bacterial diseases, not elsewhere classified
45.5
7.7
9
*
WX704
NOMESCO Finland
Intubation
2.3
7.6
59
271
02109
ICD-8 Finland
Tularaemia, Unspecified
+∞
7.3
7
*
A24.1
ICD-10 Finland
Acute and fulminating melioidosis
+∞
7.3
7
*
SPAT1263
SPAT
Sampling
1.6
7.1
279
2095
J01AA02
ATC
doxycycline; systemic
1.6
7.0
510
4382
WX720
NOMESCO Finland
Own respiration
2.6
7.0
40
160
XQ855, ,
SPAT
7.6
6.9
15
20
A21.1
ICD-10 Finland
Oculoglandular tularaemia
+∞
6.3
6
*
M49.1*A23.9
ICD-10 Finland
Brucella spondylitis
+∞
6.3
6
*
02107
ICD-8 Finland
Tularaemia, Suspecta
+∞
6.3
6
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.4
6.2
42
182
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.0
6.2
65
338
SPAT1255
SPAT
Intravenous administration of medicine
2.3
6.1
47
216
J01MA14
ATC
moxifloxacin; systemic
2.0
6.0
61
312

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
50
6
89.69
45.49
1.6
1.2
860.00
—
titre
—
22
0
252
1533
2.01
16.28
4.4
4.3
—
—
—
0
0
27
53
5.26
13.25
1.2
1.1
—
—
—
0
0
90
431
2.25
10.53
3.6
3.0
232.68
196.83
ng/l
0.38
85
394
259
1817
1.68
9.34
3.8
3.1
33.61
32.65
u/l
0.13
248
1730
347
2634
1.63
9.10
7.5
6.0
8.62
8.64
%
0.03
337
2482
346
2627
1.63
9.04
7.0
5.7
2.67
2.88
%
1.14
335
2467
32
98
3.37
8.86
2.1
1.2
—
—
—
0
0
352
2700
1.61
8.71
6.9
5.8
26.93
27.76
%
0.78
340
2547
347
2664
1.60
8.47
6.8
5.5
58.14
57.16
%
0.85
335
2517
166
1056
1.75
8.45
4.7
3.8
147.17
381.85
ng/l
1.23
130
821
334
2546
1.60
8.37
6.8
5.7
0.70
0.68
%
0.20
324
2389
308
2354
1.55
7.32
5.8
4.6
35.40
35.68
g/l
0.36
286
2203
78
412
2.01
7.06
4.6
4.5
0.46
0.15
%
0.29
26
126
79
423
1.98
6.88
4.1
4.3
0.83
0.60
%
0.38
29
149
361
2882
1.52
6.87
6.7
5.7
0.18
0.19
e9/l
0.49
334
2558
359
2865
1.52
6.83
6.6
5.5
1.76
1.92
e9/l
1.77
332
2563
334
2626
1.52
6.81
7.5
6.0
—
—
—
0
0
350
2781
1.52
6.78
6.6
5.5
0.60
0.58
e9/l
0.76
322
2428
350
2792
1.51
6.59
6.6
5.5
0.04
0.04
e9/l
0.51
322
2442
211
1515
1.56
6.46
4.1
3.3
—
—
—
0
0
83
465
1.89
6.33
4.4
4.4
1.83
0.98
%
0.70
29
179
326
2596
1.48
6.00
12.7
13.5
1.29
1.23
inr
0.44
100
753
30
112
2.75
5.99
1.2
1.3
—
—
—
0
0
77
436
1.86
5.69
4.2
4.5
0.04
0.13
%
0.93
23
150
57
292
2.04
5.63
7.2
11.1
—
—
—
0
0
391
3265
1.45
5.41
5.2
4.8
6.80
6.68
mmol/l
0.52
369
3038
27
103
2.69
5.20
1.2
1.3
106.55
101.88
u/ml
—
8
17
74
426
1.82
5.19
3.2
2.7
9.98
10.76
g/l
0.85
68
389
122
808
1.62
5.16
2.1
2.0
—
—
—
0
0
40
189
2.18
4.89
1.1
1.3
—
—
—
0
0
226
1733
1.45
4.80
2.8
2.5
54.14
59.55
u/l
0.98
215
1608
20
69
2.95
4.63
2.2
2.0
30.50
32.46
pg
0.95
20
69
61
345
1.84
4.54
1.8
1.6
1.45
1.54
g/l
0.11
55
319
219
1698
1.42
4.30
3.3
3.0
—
—
—
0
0
27
114
2.42
4.28
1.1
1.3
338.69
258.06
u/ml
0.58
13
62
540
4909
1.44
3.92
21.5
16.5
14.37
14.89
%
1.77
531
4838
96
641
1.58
3.91
5.6
8.2
5.04
5.10
kpa
0.19
90
614
325
2724
1.36
3.90
7.3
6.5
1.21
1.21
mmol/l
0.21
281
2330
62
373
1.73
3.79
1.9
2.5
—
—
—
0
0
95
638
1.57
3.78
5.7
8.3
1.77
1.14
mmol/l
0.91
71
509
376
3235
1.35
3.76
9.6
8.7
4.26
4.08
e9/l
0.69
345
2848
95
642
1.56
3.68
5.7
8.2
11.31
12.25
kpa
1.36
89
619
27
123
2.24
3.65
3.9
3.9
—
—
—
0
0
460
4106
1.35
3.47
5.4
4.0
13.27
11.92
mm/h
1.14
441
3776
14
47
3.02
3.43
1.1
1.1
—
—
—
0
0
18
70
2.61
3.40
2.3
2.5
—
—
—
0
0
433
3847
1.33
3.27
5.6
4.2
—
—
—
0
0
85
578
1.54
3.21
5.6
8.6
95.31
95.78
%
0.18
80
555
153
1168
1.40
3.18
1.8
1.7
435.82
17927896.13
pmol/l
1.04
135
965
417
3693
1.32
3.18
5.2
4.3
861.47
2284.75
e6/l
0.51
17
63
32
166
1.97
3.14
3.9
3.7
27.96
47.94
mg/l
0.52
27
129
32
166
1.97
3.14
3.9
3.7
37.30
94.36
mg/l
0.78
27
127
140
1056
1.41
3.12
1.9
1.9
—
—
—
0
0
17
68
2.54
3.06
3.1
1.9
13.14
13.11
%
0.03
17
68
25
120
2.12
3.02
3.2
4.0
20.23
26.01
mg/l
0.30
18
77
103
739
1.46
3.01
1.4
1.3
393.04
505.00
titre
0.50
23
160
473
4284
1.32
2.96
9.1
7.4
76.54
77.90
u/l
0.24
454
4020
67
442
1.57
2.90
2.5
2.7
66.00
67.03
g/l
0.51
61
401
59
379
1.61
2.86
4.9
5.8
—
—
—
0
0
70
470
1.54
2.81
7.7
6.4
11.23
9.62
mmol/l
0.85
65
447
433
3891
1.30
2.78
4.0
3.8
—
—
—
0
0
334
2905
1.29
2.77
7.3
6.2
11.23
11.31
umol/l
0.05
320
2745
24
118
2.07
2.74
3.5
1.2
19.58
9.24
e6/l
0.23
19
93
517
4773
1.32
2.63
22.4
17.8
333.94
332.83
g/l
2.00
508
4741
23
114
2.05
2.59
1.7
1.7
—
—
—
0
0
74
513
1.49
2.58
3.7
3.2
1.81
1.96
mmol/l
0.14
61
418
605
5727
1.42
2.56
19.8
16.1
139.40
139.65
mmol/l
1.62
592
5575
22
108
2.07
2.54
3.7
1.3
—
—
—
0
0
606
5744
1.41
2.49
20.3
16.2
3.99
3.97
mmol/l
0.54
592
5581
9
26
3.49
2.49
4.4
6.0
—
—
—
0
0
174
1405
1.32
2.49
2.4
2.1
2.76
3.05
mg/l
0.94
152
1196
67
461
1.50
2.43
2.9
2.8
72.75
71.65
e9/l
0.08
56
358
12
46
2.64
2.37
5.8
1.2
—
—
—
0
0
17
79
2.18
2.26
1.1
1.2
—
—
—
0
0
157
1268
1.31
2.23
1.7
1.7
1.12
1.20
mg/l
0.16
130
964
5
9
5.59
2.21
1.2
1.3
—
—
—
0
0
119
925
1.35
2.20
1.2
1.3
21.92
32.67
iu/ml
0.71
44
297
311
2734
1.25
2.20
4.3
3.6
0.00
0.00
estimate
0.50
70
549
248
2135
1.25
2.09
4.0
3.7
58.99
50.59
ng/l
0.14
162
1497
21
110
1.94
2.07
3.0
2.7
14.71
15.99
%
0.87
13
56
199
1672
1.27
2.06
2.7
2.1
212.93
279.65
u/l
0.35
187
1572
99
1272
0.74
2.04
3.9
3.5
—
—
—
0
0
299
2634
1.24
2.03
2.9
2.6
—
—
—
0
0
20
104
1.95
2.02
3.3
2.6
—
—
—
0
0
309
2735
1.23
2.00
5.7
4.8
0.00
0.00
estimate
-0.00
67
516
254
2205
1.24
1.96
3.7
3.3
5.84
5.81
ph
0.07
19
155
100
776
1.34
1.88
2.8
2.2
2.35
2.33
g/l
0.12
93
720
311
2768
1.22
1.88
4.2
3.6
0.00
0.01
estimate
0.50
65
489
11
46
2.41
1.86
1.2
1.1
—
—
—
0
0
108
1348
0.76
1.80
3.4
2.4
—
—
—
0
0
274
2420
1.22
1.76
3.3
2.7
129.98
125.62
ug/l
0.12
251
2235
110
875
1.31
1.75
1.1
1.3
7.61
10.51
u/ml
0.19
37
335
139
1142
1.27
1.72
3.8
2.5
3.97
5.85
e6/l
1.17
129
1027
149
1245
1.25
1.60
4.0
3.8
1.02
1.02
kg/l
0.11
28
178
8
33
2.44
1.54
1.9
1.5
—
—
—
0
0
85
665
1.32
1.54
1.8
1.6
—
—
—
0
0
7
27
2.61
1.51
1.3
2.0
478.43
757.67
u/ml
—
7
27
5
127
0.39
1.51
1.0
1.3
—
—
—
0
0
586
5620
1.26
1.49
18.7
14.1
29.14
23.78
mg/l
2.47
503
4442
36
517
0.68
1.46
2.1
2.3
54.00
32.19
u/l
0.37
31
441
25
157
1.61
1.42
1.2
1.2
101.25
70.00
titre
—
8
12
191
2176
0.83
1.38
1.8
2.1
—
—
—
0
0
6
23
2.62
1.37
1.2
1.2
—
21.33
—
0
6
15
82
1.85
1.36
2.3
2.9
—
—
—
0
0
20
120
1.69
1.35
4.0
3.9
2.25
2.78
mmol/l
0.33
15
83
197
1724
1.20
1.35
3.3
3.1
7.64
7.78
mmol/l
0.17
178
1444
10
47
2.14
1.34
1.6
1.2
—
—
—
0
0
6
24
2.51
1.30
1.5
1.8
—
—
—
0
0
14
76
1.86
1.30
2.1
2.8
—
—
—
0
0
181
1577
1.20
1.29
3.6
3.2
1153.41
180.19
mg/l
1.08
129
1039
8
34
2.37
1.29
1.3
3.4
—
—
—
0
0
121
1013
1.24
1.29
1.7
1.7
1314.64
1172.85
nmol/l
0.53
101
767
38
525
0.71
1.27
4.3
4.2
—
—
—
0
0
5
115
0.43
1.26
1.8
1.5
—
—
—
0
0
53
400
1.35
1.25
3.6
3.7
87.34
79.68
ng/l
0.27
47
356
23
147
1.58
1.24
1.3
1.2
—
2.58
—
0
19
186
1636
1.19
1.19
4.8
3.7
7.39
7.40
ph
0.20
44
302
90
736
1.26
1.19
3.0
2.2
18.77
23.60
%
2.83
72
635
81
656
1.27
1.16
1.8
1.6
—
—
—
0
0
222
1988
1.17
1.15
3.1
2.8
—
—
—
0
0
16
95
1.70
1.14
3.3
1.6
—
—
—
0
0
28
192
1.48
1.13
3.7
2.2
4124.03
4762.42
u/l
0.05
13
82
5
114
0.43
1.13
1.8
1.4
—
—
—
0
0
5
114
0.43
1.13
1.8
1.4
—
—
—
0
0
7
30
2.35
1.12
1.0
1.3
—
—
—
0
0
7
32
2.20
1.08
1.0
1.6
10.43
10.00
mmol/l
—
7
32
614
5967
1.24
1.06
12.4
10.1
28.27
26.76
u/l
0.77
602
5755
79
646
1.25
1.06
2.7
2.7
6.40
8.50
umol/l
1.05
68
562
87
721
1.24
1.04
7.3
5.2
1.08
1.03
mmol/l
1.01
82
665
5
22
2.28
1.03
1.6
1.2
—
1.20
—
0
5
10
53
1.90
1.01
1.1
1.3
—
—
—
0
0
128
1107
1.19
1.00
1.5
1.4
2.67
2.47
g/l
0.50
89
688
7
35
2.01
1.00
1.3
3.4
—
—
—
0
0
74
896
0.81
0.99
2.8
2.8
2.35
2.45
e6/l
0.03
47
470
53
417
1.29
0.98
1.6
1.5
—
—
—
0
0
16
100
1.61
0.97
4.2
2.5
—
—
—
0
0
9
50
1.81
0.97
2.0
2.5
—
—
—
0
0
55
437
1.28
0.95
3.4
2.6
4.60
4.51
kpa
0.10
49
417
268
2466
1.14
0.93
13.3
9.3
0.00
0.00
e9/l
0.30
228
2038
6
27
2.23
0.93
1.0
1.3
—
—
—
0
0
10
55
1.83
0.92
3.1
2.9
—
—
—
0
0
13
78
1.68
0.92
1.2
1.4
—
—
—
0
0
6
28
2.15
0.91
1.0
1.1
—
0.46
—
0
9
6
28
2.15
0.91
1.8
3.6
87.33
94.29
nmol/l
—
6
28
398
3762
1.13
0.91
3.6
3.1
47.95
50.55
u/l
0.27
371
3518
99
845
1.20
0.90
3.0
2.2
11.52
13.42
umol/l
1.85
92
787
120
1373
0.85
0.90
8.8
6.7
—
—
—
0
0
48
378
1.29
0.89
2.8
2.6
12.29
4.92
e9/l
0.66
42
312
249
2289
1.14
0.87
2.4
2.2
79.61
76.81
nmol/l
0.72
236
2040
8
43
1.87
0.87
3.0
3.0
—
—
—
0
0
8
43
1.87
0.87
1.1
1.9
37.43
38.48
%
—
8
43
8
43
1.87
0.87
1.0
1.2
—
—
—
0
0
6
30
2.01
0.87
1.0
1.4
123.33
154.71
nmol/l
—
6
30
64
773
0.81
0.85
1.4
1.2
—
—
—
0
0
15
96
1.57
0.85
1.0
1.1
—
—
—
0
0
8
45
1.79
0.84
2.5
1.6
1.20
1.19
promille
—
8
32
8
139
0.57
0.84
1.8
2.3
—
—
—
0
0
185
1674
1.14
0.82
4.1
3.8
8.35
9.89
mg/mmol
0.20
129
1065
14
89
1.58
0.81
1.1
1.2
2.40
7.16
u/ml
—
5
38
147
1310
1.15
0.81
1.7
1.5
19.45
20.77
nmol/l
0.58
136
1112
16
235
0.67
0.80
4.2
4.0
25.92
24.92
mmol/l
0.65
16
221
0
25
0.00
0.79
0.0
1.5
—
—
—
0
0
11
66
1.68
0.79
1.3
1.8
—
—
—
0
0
31
234
1.34
0.79
1.8
2.1
1.34
1.46
g/l
0.24
21
208
7
122
0.57
0.78
1.4
1.5
—
—
—
0
0
242
2237
1.13
0.77
2.1
1.9
99.26
95.79
pmol/l
0.45
137
1155
56
676
0.81
0.76
1.2
1.3
—
—
—
0
0
10
59
1.70
0.76
2.2
2.5
—
—
—
0
0
11
173
0.63
0.76
24.8
10.2
—
—
—
0
0
98
1122
0.85
0.75
2.4
2.9
0.60
0.76
ug/l
1.87
61
706
36
456
0.78
0.74
3.8
3.2
—
—
—
0
0
600
5860
1.17
0.73
18.0
13.1
—
—
—
0
0
5
25
2.01
0.73
2.2
1.6
26.00
58.24
ug/l
—
5
25
17
117
1.46
0.72
4.5
3.3
—
—
—
0
0
9
57
1.59
0.71
1.0
1.2
—
—
—
0
0
5
26
1.93
0.70
1.0
1.0
—
—
—
0
0
638
6266
1.21
0.70
25.8
20.4
248.73
247.77
e9/l
0.13
624
6113
7
41
1.71
0.70
1.1
1.2
209.40
178.98
pmol/l
—
7
41
440
4223
1.11
0.69
4.3
3.8
14.63
14.78
pmol/l
0.64
416
3810
15
102
1.48
0.68
4.1
3.6
57.07
58.41
%
0.12
15
102
638
6269
1.20
0.68
25.7
20.3
90.92
90.90
fl
0.04
629
6180
638
6270
1.20
0.67
25.8
20.4
6.70
6.72
e9/l
0.11
625
6095
5
28
1.79
0.66
1.0
1.1
—
0.35
—
0
9
638
6271
1.20
0.66
25.8
20.4
4.47
4.51
e12/l
1.43
625
6099
638
6271
1.20
0.66
25.6
20.3
30.33
30.30
pg
0.16
629
6181
198
1826
1.12
0.65
3.7
3.3
2.35
2.35
mmol/l
0.13
180
1610
161
1760
0.89
0.64
3.0
2.5
—
—
—
0
0
156
1420
1.13
0.64
3.3
2.6
2549.58
6197.60
umol/l
0.82
145
1234
638
6274
1.19
0.63
25.9
20.5
134.94
135.95
g/l
1.00
629
6180
52
434
1.21
0.63
1.2
1.2
—
—
—
0
0
15
211
0.70
0.63
2.8
3.1
0.58
0.22
g/l
—
6
84
265
2487
1.11
0.63
6.3
5.8
1.21
1.21
mmol/l
0.41
250
2260
6
101
0.59
0.62
2.5
1.6
64.83
61.36
%
—
6
101
8
50
1.61
0.61
1.3
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
357.17
—
0
12
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
18
243
0.73
0.60
1.0
1.1
—
—
—
0
0
173
1594
1.11
0.58
3.1
3.0
1526.70
1262.64
ng/l
0.31
151
1354
65
560
1.18
0.58
3.3
4.4
10.45
33.75
ug/l
0.82
49
477
15
207
0.72
0.57
2.5
4.1
1.62
1.31
mmol/l
0.56
15
200
14
98
1.44
0.57
4.0
3.2
3.22
4.46
e9/l
2.65
14
98
183
1695
1.11
0.56
4.0
3.1
30.36
101.98
e6/l
1.11
158
1289
10
65
1.55
0.55
1.3
1.3
—
—
—
0
0
55
471
1.18
0.53
6.1
3.7
—
—
—
0
0
98
879
1.13
0.52
1.7
1.6
—
—
—
0
0
636
6268
1.16
0.51
25.8
20.4
48.44
40.34
%
0.46
551
5870
138
1265
1.11
0.51
1.2
1.2
1.01
1.52
u/ml
0.66
35
351
15
109
1.38
0.51
1.0
1.0
—
—
—
0
0
53
455
1.18
0.50
6.2
7.9
—
—
—
0
0
62
540
1.16
0.50
1.4
1.4
—
—
—
0
0
29
355
0.81
0.49
2.3
2.7
—
—
—
0
0
553
5412
1.10
0.48
4.4
4.4
5.95
5.95
mmol/l
0.01
521
4924
208
1958
1.09
0.46
4.2
3.6
49.18
108.52
e6/l
1.26
168
1373
18
139
1.30
0.44
2.0
1.8
5.06
5.28
iu/l
—
8
43
18
229
0.78
0.43
2.1
1.8
—
—
—
0
0
522
5107
1.09
0.42
5.1
4.6
1.88
2.12
mu/l
0.48
497
4652
62
697
0.88
0.41
2.2
2.3
174.81
123.25
ug/g
0.32
53
561
14
105
1.34
0.41
3.6
2.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
8
59
1.36
0.41
1.4
1.3
—
—
—
0
0
205
1938
1.08
0.41
5.0
4.7
1.93
2.54
ug/l
1.44
190
1738
97
886
1.11
0.40
4.8
3.2
0.83
0.82
mmol/l
0.25
90
835
0
18
0.00
0.40
0.0
2.2
—
—
—
0
0
36
307
1.18
0.39
1.2
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
20
161
1.25
0.37
3.3
2.9
—
—
—
0
0
19
152
1.26
0.37
3.5
4.6
—
—
—
0
0
150
1597
0.92
0.37
4.5
3.9
—
—
—
0
0
9
70
1.29
0.36
5.7
4.7
—
—
—
0
0
139
1483
0.92
0.36
3.7
2.9
—
—
—
0
0
23
277
0.82
0.36
3.7
3.6
—
—
—
0
0
6
46
1.31
0.33
1.0
1.3
—
—
—
0
0
7
52
1.35
0.31
9.0
1.3
—
—
—
0
0
25
212
1.19
0.30
1.1
1.1
—
—
—
0
0
155
1469
1.07
0.30
1.9
1.7
1.47
1.38
mmol/l
0.56
135
1240
95
1019
0.92
0.29
2.5
2.9
2.47
2.45
mmol/l
0.74
85
896
33
289
1.15
0.28
2.6
2.3
—
—
—
0
0
8
62
1.29
0.28
1.0
1.1
—
—
—
0
0
15
122
1.23
0.27
2.7
2.3
—
—
—
0
0
8
66
1.21
0.27
1.4
1.3
—
—
—
0
0
14
171
0.82
0.26
1.2
1.2
—
—
—
0
0
17
203
0.83
0.26
1.5
1.6
—
—
—
0
0
10
127
0.78
0.25
1.0
1.3
—
—
—
0
0
9
73
1.24
0.25
1.2
1.4
31.96
32.67
g/l
—
9
63
42
378
1.12
0.25
3.4
3.5
7.41
7.41
ph
—
10
48
14
114
1.23
0.25
1.1
1.2
—
—
—
0
0
73
678
1.09
0.24
1.5
1.4
—
—
—
0
0
23
265
0.86
0.24
1.1
1.1
—
95.86
—
0
7
6
83
0.72
0.24
1.0
1.1
—
6.70
—
0
46
116
1099
1.07
0.23
3.4
2.9
528.99
551.32
mosm/kgh2o
0.48
106
944
39
352
1.11
0.23
1.2
1.2
—
—
—
0
0
7
94
0.74
0.22
1.1
1.1
—
—
—
0
0
5
40
1.25
0.22
1.4
1.5
141.80
76.57
umol/l
—
5
40
7
95
0.73
0.22
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
16.98
—
0
10
0
10
0.00
0.21
0.0
1.0
—
0.09
—
0
10
147
1532
0.95
0.21
3.7
3.0
0.13
0.52
e6/l
5.21
122
1141
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
3.4
—
—
—
0
0
519
5126
1.05
0.20
5.9
5.6
40.57
39.87
mmol/mol
0.84
496
4767
6
51
1.18
0.19
3.5
1.4
—
—
—
0
0
553
5472
1.05
0.19
4.3
4.3
1.43
1.45
mmol/l
0.42
527
5048
12
143
0.84
0.18
1.2
1.1
—
—
—
0
0
42
456
0.92
0.18
1.4
1.4
—
—
—
0
0
7
60
1.17
0.18
2.0
2.1
—
—
—
0
0
58
618
0.93
0.17
1.2
1.3
—
—
—
0
0
5
66
0.76
0.17
1.2
1.3
0.54
0.55
nmol/l
—
5
60
21
187
1.13
0.16
3.7
1.9
—
—
—
0
0
555
5501
1.04
0.15
4.5
4.3
4.60
4.63
mmol/l
0.17
529
5105
145
1499
0.96
0.15
5.2
3.8
0.00
0.01
estimate
0.88
66
498
6
78
0.77
0.15
1.0
1.1
—
1.00
—
0
34
30
275
1.09
0.14
3.4
3.8
—
—
—
0
0
7
88
0.79
0.14
2.0
1.4
—
—
—
0
0
531
5264
1.04
0.13
3.9
3.9
1.27
1.29
mmol/l
0.23
502
4829
5
44
1.14
0.10
1.4
1.4
—
—
—
0
0
32
340
0.94
0.09
1.6
1.4
—
—
—
0
0
55
528
1.05
0.09
2.7
2.3
0.22
0.21
g/l
0.17
50
496
5
64
0.78
0.08
1.6
1.6
—
—
—
0
0
17
156
1.09
0.08
4.5
2.9
—
—
—
0
0
53
550
0.96
0.07
1.5
1.4
—
—
—
0
0
159
1563
1.02
0.07
1.4
1.5
—
—
—
0
0
14
153
0.91
0.07
3.2
2.3
59.96
71.23
ug/min
—
9
87
7
83
0.84
0.07
1.1
1.2
—
—
—
0
0
24
255
0.94
0.07
1.7
1.7
—
—
—
0
0
20
214
0.93
0.07
3.1
2.7
—
—
—
0
0
21
224
0.94
0.06
1.3
1.2
—
—
—
0
0
23
217
1.06
0.06
3.4
1.9
—
—
—
0
0
563
5613
1.02
0.04
4.9
4.8
2.75
2.74
mmol/l
0.10
532
5172
27
261
1.04
0.02
3.3
2.1
0.71
0.65
%
0.35
27
261
24
232
1.04
0.02
3.4
1.9
—
—
—
0
0
16
167
0.96
0.01
1.3
1.2
—
—
—
0
0
57
578
0.98
0.01
1.7
1.7
—
—
—
0
0
24
233
1.03
0.01
3.3
1.7
—
—
—
0
0
24
234
1.03
0.00
3.3
1.9
—
—
—
0
0
21
215
0.98
0.00
4.8
4.4
—
—
—
0
0
24
235
1.02
0.00
4.5
1.9
—
—
—
0
0
37
365
1.01
0.00
1.4
1.2
273.56
158.32
iu/ml
0.54
12
146
63
626
1.01
0.00
1.4
1.6
—
—
—
0
0
40
403
0.99
0.00
1.5
1.4
—
—
—
0
0
54
543
0.99
0.00
1.4
1.3
—
—
—
0
0
22
221
1.00
0.00
1.4
3.3
19.65
6335.49
u/ml
0.79
17
190
9
93
0.97
0.00
1.2
1.1
—
11.26
—
0
9
9
93
0.97
0.00
1.6
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
12
120
1.00
-0.00
1.1
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
99
0.91
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
78
0.90
-0.00
3.0
2.7
4.13
4.01
mmol/l
—
7
78
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.2
1.3
—
—
—
0
0
5
56
0.89
-0.00
1.0
1.4
266.20
279.74
mosm/kgh2o
—
5
43
7
77
0.91
-0.00
3.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
1.2
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
78
0.90
-0.00
3.0
2.7
107.57
105.41
mmol/l
—
7
78
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_ZOONOTIC_BACTERIAL and mortality.

Females

Parameter HR [95% CI] p-value
AB1_ZOONOTIC_BACTERIAL 1.32 [1.11, 1.57] 0.002
Birth year 0.998 [0.99, 1.01] 0.644

During the follow-up period (1.1.1998 — 31.12.2019), 303 out of 1976 females with AB1_ZOONOTIC_BACTERIAL died.

Males

Parameter HR [95% CI] p-value
AB1_ZOONOTIC_BACTERIAL 1.111 [0.96, 1.29] 0.16
Birth year 0.988 [0.98, 1.0] 0.015

During the follow-up period (1.1.1998 — 31.12.2019), 369 out of 2439 males with AB1_ZOONOTIC_BACTERIAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_ZOONOTIC_BACTERIAL.

N-year risk Females Males
1 0.128% 0.284%
5 0.806% 1.415%
10 2.18% 3.598%
15 4.413% 6.727%
20 7.549% 11.22%

Relationships between endpoints

↥

Index endpoint: AB1_ZOONOTIC_BACTERIAL – Certain zoonotic bacterial diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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