Other zoonotic bacterial diseases, not elsewhere classified

AB1_OTHER_ZOONOTIC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — A28 Hospital discharge: ICD-9 — 02[7] Hospital discharge: ICD-8 — 02[7] Hospital discharge: excluded ICD-9 — 027[0-1] Hospital discharge: excluded ICD-8 — 027[0-1] Cause of death: ICD-10 — A28 Cause of death: ICD-9 — 02[7] Cause of death: ICD-8 — 02[7] Cause of death: excluded ICD-9 — 027[0-1] Cause of death: excluded ICD-8 — 027[0-1] 2 out of 7 registries used, show all original rules.	42
4. Check minimum number of events None	42
5. Include endpoints None	42
6. Filter based on genotype QC (FinnGen only)	42

Control definitions (FinnGen only)

Control exclude: AB1_ZOONOTIC_BACTERIAL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF5

NAME	AB1_OTHER_ZOONOTIC
CONTROL_EXCLUDE	AB1_ZOONOTIC_BACTERIAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A28
HD_ICD_9	02[7]
HD_ICD_8	02[7]
HD_ICD_10_EXCL
HD_ICD_9_EXCL	027[0-1]
HD_ICD_8_EXCL	027[0-1]
COD_MAINONLY
COD_ICD_10	A28
COD_ICD_9	02[7]
COD_ICD_8	02[7]
COD_ICD_10_EXCL
COD_ICD_9_EXCL	027[0-1]
COD_ICD_8_EXCL	027[0-1]
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other zoonotic bacterial diseases, not elsewhere classified based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	386	218	166
Only index persons	343	192	151
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.00
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	58.47	61.50	54.61
Only index persons	55.74	58.52	52.21

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	42	29	13
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	63.14	64.31	60.52

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3033658) Prothrombin time (PT) actual/Normal

4.71

5.67

6.3

3.8

92.4

91.7

0.03

(3023368) Bacteria identified in Blood by Culture

4.38

5.28

7.7

4.7

—

(3052851) Hemolysis interference index of Serum or Plasma

13.62

4.45

4.7

5.7

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

3.93

3.95

3.1

2.9

143.9

273.7

ng/l

—

(3012544) pH of Venous blood

4.38

3.43

2.9

2.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.06

3.13

1.9

1.7

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

3.13

3.01

2.6

2.5

3.2

3.3

mg/l

—

(3000991) Gas panel - Venous blood

4.68

2.98

3.6

6.7

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

3.03

2.86

1.6

1.4

1.0

mg/l

0.28

(3044640) Blood type and Crossmatch panel - Blood

103

2.80

2.63

3.4

2.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

133

2.61

2.35

2.2

1.8

98.1

104.2

pmol/l

0.30

(3006315) Basophils [#/volume] in Blood

161

2.61

2.29

7.8

5.3

0.0

e9/l

0.23

148

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

6.13

2.28

1.0

1.4

—

(3001604) Monocytes [#/volume] in Blood

162

2.59

2.25

7.8

5.2

0.6

e9/l

0.11

147

(40758558) Short blood count panel - Blood

2.60

2.20

6.7

6.9

—

(3007853) Bacteria identified in Skin by Aerobe culture

3.14

2.19

3.0

1.5

—

(3001122) Ferritin [Mass/volume] in Serum or Plasma

129

2.48

2.14

2.8

110.9

86.5

ug/l

0.46

122

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

5.50

2.13

1.8

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

5.50

2.13

1.8

1.0

—

(3019198) Lymphocytes [#/volume] in Blood

168

2.44

2.00

7.8

5.2

1.7

e9/l

0.18

156

(3021589) Normoblasts [#/volume] in Blood

133

2.37

1.95

9.2

9.7

0.0

e9/l

0.50

109

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.94

1.76

2.1

1.5

—

(3042936) Bacteria identified in Isolate by Culture

2.57

1.68

4.3

1.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.57

1.68

1.8

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.15

1.57

1.2

3.0

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.32

1.54

4.2

2.4

—

(42870588) Differential panel, method unspecified - Blood

111

2.09

1.43

7.1

5.1

—

(3007164) IgA [Mass/volume] in Serum or Plasma

2.27

1.40

1.8

1.7

4.1

3.5

g/l

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

215

2.13

1.39

2.8

2.7

41.0

52.1

u/l

0.80

200

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.50

1.33

1.5

1.4

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

197

2.04

1.33

11.7

8.0

4.7

4.0

e9/l

0.68

175

(3014007) Fractional oxyhemoglobin in Arterial blood

2.84

1.25

3.0

7.9

93.4

91.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

2.21

1.13

1.9

1.7

—

(3017732) Neutrophils [#/volume] in Blood

0.00

1.02

0.0

2.7

—

3.6

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

106

1.82

0.98

2.5

3.7

1644.0

1630.6

ng/l

0.01

(3026008) Bacteria identified in Urine by Culture

107

1.80

0.94

3.1

3.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.96

0.91

1.5

1.4

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.82

0.0

4.0

—

0.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.33

0.79

2.2

1.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.90

0.76

8.6

4.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

210

1.63

0.72

5.5

2.9

—

(36304419) Bacteria [Presence] in Urine

1.67

0.68

3.6

2.8

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.71

0.62

1.3

—

1.3

—

(43055554) Base excess.100% oxygenated [Moles/volume] standard in Capillary blood by calculation

0.00

0.62

0.0

3.2

—

1.5

—

(3009542) Hematocrit [Volume Fraction] of Blood

304

1.62

0.56

41.6

13.6

36.1

39.9

0.99

216

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

301

1.68

0.56

4.7

4.8

1.9

mu/l

0.03

267

(40768804) Tissue Pathology biopsy report

131

1.50

0.54

1.4

2.1

—

(3018095) Leukocytes [#/volume] in Urine

122

1.50

0.53

3.6

3.7

260.6

83.8

e6/l

0.32

(40768797) Stomach Pathology biopsy report

1.62

0.51

1.3

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

330

1.63

0.49

37.9

14.8

29.0

20.3

mg/l

0.85

249

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

307

1.56

0.45

5.9

40.2

40.4

mmol/mol

0.04

287

(4035726)

1.58

0.43

1.2

1.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.42

0.0

1.7

—

(3044889) 12 lead EKG panel

236

1.40

0.40

4.3

3.6

—

(3027945) Reticulocytes/100 erythrocytes in Blood

1.39

0.35

1.7

2.6

1.5

1.8

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.45

0.34

3.3

2.2

15.7

17.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.41

0.33

1.0

1.5

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.27

0.28

3.9

3.7

—

(3031040) Bacteria [#/volume] in Urine by Automated count

224

1.29

0.26

6.1

5.1

—

479.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

134

0.76

0.25

4.7

4.8

—

(3003694) ABO and Rh group [Type] in Blood

1.32

0.24

1.4

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

3.6

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.9

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.21

0.0

2.0

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

26.5

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.7

—

1.1

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.6

—

0.2

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.21

0.0

3.3

—

24.9

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.21

0.0

1.8

—

0.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.20

0.0

2.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

149

1.24

0.20

6.6

4.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

349

0.86

0.17

34.7

16.8

73.8

77.3

umol/l

0.36

349

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

122

1.22

0.16

4.9

3.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.81

0.15

3.5

4.5

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

326

0.81

0.15

3.7

4.2

1.5

mmol/l

0.07

292

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

326

0.81

0.15

4.6

4.1

6.2

6.0

mmol/l

0.19

298

(40760892) CBC W Ordered Manual Differential panel - Blood

0.84

0.08

5.4

4.4

—

(40761511) CBC panel - Blood by Automated count

341

1.16

0.08

28.7

14.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

336

0.92

0.08

4.5

4.7

2.7

2.8

mmol/l

0.13

305

(3015736) pH of Urine

130

1.12

0.05

3.5

4.3

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

312

1.11

0.03

3.6

3.8

1.2

1.3

mmol/l

0.21

276

(3037467) Urinalysis macro (dipstick) panel - Urine

233

1.07

0.02

4.2

4.7

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

13.3

—

(3013512) EKG study

0.95

0.00

3.9

4.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.1

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.0

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.4

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.0

1.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.0

2.4

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.0

—

0.8

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.7

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

2.1

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.0

1.6

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

12.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.5

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

3.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.0

2.8

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

0.0

2.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.2

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3018171) Choriogonadotropin [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

2.0

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.0

1.6

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.7

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3023420) DNA double strand Ab [Units/volume] in Serum

0.00

0.0

1.7

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.2

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

2.8

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

8.8

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

7.2

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.4

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

2.0

—

440.4

—

(4146454)

0.00

0.0

3.8

—

Mortality – FinRegistry

↥

Association

Association between endpoint AB1_OTHER_ZOONOTIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_ZOONOTIC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: AB1_OTHER_ZOONOTIC – Other zoonotic bacterial diseases, not elsewhere classified

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other zoonotic bacterial diseases, not elsewhere classified

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints