Tularaemia

AB1_TULARAEMIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A21
  • Hospital discharge: ICD-9 02[1]
  • Hospital discharge: ICD-8 02[1]
  • Cause of death: ICD-10 A21
  • Cause of death: ICD-9 02[1]
  • Cause of death: ICD-8 02[1]

2 out of 7 registries used, show all original rules.

489

4. Check minimum number of events

None

489

5. Include endpoints

None

489

6. Filter based on genotype QC (FinnGen only)

478

Control definitions (FinnGen only)

Control exclude
AB1_ZOONOTIC_BACTERIAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4460 1976 2467
Only index persons 4103 1830 2273
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.07
Only index persons 0.08 0.07 0.09
Median age at first event (years)
Whole population 46.83 48.39 45.50
Only index persons 46.01 47.63 44.71

-FinnGen-

Key figures

All Female Male
Number of individuals 478 233 245
Unadjusted period prevalence (%) 0.10 0.08 0.11
Median age at first event (years) 51.19 48.78 53.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
489
Matched controls
4890
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A21.9
ICD-10 Finland
Tularaemia, unspecified
5278.1
273.7
238
*
A21.0
ICD-10 Finland
Ulceroglandular tularaemia
+∞
142.9
130
*
J01MA02
ATC
ciprofloxacin; systemic
5.8
79.4
330
1281
R50.9
ICD-10 Finland
Fever, unspecified
4.4
44.2
142
418
A21.2
ICD-10 Finland
Pulmonary tularaemia
+∞
31.6
30
*
A21.8
ICD-10 Finland
Other forms of tularaemia
+∞
23.1
22
*
A98.5
ICD-10 Finland
Haemorrhagic fever with renal syndrome
6.8
18.1
29
45
A21
ICD-10 Finland
Tularaemia
+∞
16.8
16
*
0210A
ICD-9 Finland
Tularaemia, Ulceroglandular tularaemia
+∞
16.8
16
*
J17.0*A21.2
ICD-10 Finland
Pneumonia (due to)(in) tularaemia
+∞
15.7
15
*
02100
ICD-8 Finland
Tularaemia, Glanduraris sive ulceroglandularis
+∞
13.6
13
*
0219X
ICD-9 Finland
Tularaemia, Unspecified tularaemia
+∞
13.6
13
*
WX720
NOMESCO Finland
Own respiration
3.9
12.7
39
107
WX704
NOMESCO Finland
Intubation
3.1
12.0
53
185
UDC00
NOMESCO Finland
Ear microscopy
2.9
10.6
51
187
0218X
ICD-9 Finland
Tularaemia, Other specified tularaemia
+∞
10.5
10
*
A21.7
ICD-10 Finland
Generalized tularaemia
+∞
10.5
10
*
SPAT1263
SPAT
Sampling
1.9
10.1
216
1455
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.7
9.8
55
218
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.2
9.6
26
65
Z01.8
ICD-10 Finland
Other specified special examinations
2.0
9.6
119
666
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.4
9.2
66
296
SPAT1044
SPAT
Tympanometry
4.5
8.7
21
48
SPAT1324
SPAT
Screening procedure
2.2
8.4
75
369
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.8
8.2
149
942
XQ855, ,
SPAT
10.3
7.6
14
14
SPAT1255
SPAT
Intravenous administration of medicine
2.8
7.4
36
133
02109
ICD-8 Finland
Tularaemia, Unspecified
+∞
7.3
7
*
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.6
7.2
17
38
J01AA02
ATC
doxycycline; systemic
1.8
7.2
364
3029
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.7
6.7
195
1396
J01MA12
ATC
levofloxacin; systemic
1.9
6.5
96
564
SPAT1310
SPAT
Counselling related to known health issue
1.7
6.5
154
1041
SPAT1301
SPAT
No procedures
1.7
6.5
151
1016
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.8
6.5
33
125
SPAT1285
SPAT
Provision of consultation response
2.9
6.3
30
109
A21.1
ICD-10 Finland
Oculoglandular tularaemia
+∞
6.3
6
*
02107
ICD-8 Finland
Tularaemia, Suspecta
+∞
6.3
6
*
WVA20, ,
SPAT
3.8
6.3
19
52
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
6.2
107
659

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
5
108.68
45.70
1.7
1.0
860.00
—
titre
—
22
0
26
41
6.64
15.98
1.2
1.1
—
—
—
0
0
182
1050
2.17
14.36
3.9
4.3
—
—
—
0
0
30
65
4.85
13.24
2.2
1.3
—
—
—
0
0
169
1053
1.92
10.09
4.0
3.2
—
—
—
0
0
125
738
1.93
8.57
4.9
3.6
162.98
289.82
ng/l
0.57
100
569
191
1316
1.74
7.80
4.1
3.2
32.51
32.08
u/l
0.06
183
1258
58
275
2.26
7.08
5.1
4.7
0.75
0.13
%
0.37
16
85
59
284
2.23
6.94
4.4
4.4
1.11
0.43
%
1.04
19
101
243
1837
1.64
6.70
6.7
5.6
2.68
2.87
%
0.70
238
1727
63
316
2.14
6.69
4.8
4.5
2.20
0.94
%
0.77
20
125
248
1891
1.63
6.56
6.7
5.7
27.61
27.85
%
0.14
242
1787
245
1864
1.63
6.53
6.4
5.5
57.12
57.18
%
0.03
239
1766
174
1217
1.67
6.46
2.8
2.6
54.88
61.45
u/l
0.85
166
1130
59
294
2.14
6.37
4.4
4.6
0.06
0.15
%
0.55
16
103
239
1833
1.59
5.99
7.5
5.9
—
—
—
0
0
46
213
2.28
5.94
6.7
12.1
—
—
—
0
0
257
2008
1.59
5.93
6.6
5.7
0.18
0.19
e9/l
0.73
243
1780
216
1625
1.59
5.83
6.0
4.7
35.64
35.79
g/l
0.14
202
1524
255
1999
1.58
5.73
6.3
5.5
1.81
1.97
e9/l
1.13
242
1788
285
2296
1.58
5.66
4.9
4.9
6.78
6.71
mmol/l
0.22
269
2136
17
47
3.71
5.53
3.1
2.1
13.14
13.14
%
0.01
17
47
119
781
1.69
5.50
1.8
1.7
429.90
6144833.51
pmol/l
0.50
108
651
233
1803
1.56
5.45
10.9
12.5
1.24
1.24
inr
0.03
79
522
246
1947
1.53
5.07
6.3
5.5
0.61
0.58
e9/l
1.42
233
1703
246
1951
1.53
5.00
6.3
5.5
0.04
0.04
e9/l
0.69
233
1712
155
1117
1.57
4.84
3.1
2.9
—
—
—
0
0
32
139
2.39
4.79
1.1
1.3
—
—
—
0
0
22
79
2.87
4.78
4.5
4.3
—
—
—
0
0
337
2879
1.55
4.71
5.6
4.0
13.32
11.46
mm/h
1.42
328
2652
440
4024
1.93
4.67
17.0
15.8
139.36
139.67
mmol/l
1.87
434
3913
14
31
4.62
4.59
1.1
1.0
—
—
—
0
0
314
2656
1.51
4.48
5.6
4.1
—
—
—
0
0
440
4037
1.90
4.43
17.7
15.9
4.00
3.97
mmol/l
0.96
434
3922
23
89
2.66
4.37
3.3
4.2
21.12
24.90
mg/l
0.17
17
58
46
247
1.95
4.09
5.7
6.2
—
—
—
0
0
320
2746
1.48
4.03
3.9
3.7
—
—
—
0
0
21
83
2.60
3.85
1.1
1.3
323.91
282.84
u/ml
0.20
11
43
80
518
1.65
3.83
1.3
1.3
368.89
503.86
titre
0.54
18
114
300
2563
1.44
3.72
5.3
4.1
861.47
1799.50
e6/l
0.23
17
44
62
964
0.59
3.69
10.8
6.7
—
—
—
0
0
84
559
1.61
3.60
1.8
2.1
—
—
—
0
0
21
86
2.51
3.60
1.3
1.3
—
—
—
0
0
119
862
1.50
3.50
3.9
3.7
1.02
1.02
kg/l
0.06
24
111
44
247
1.86
3.45
2.3
2.4
—
—
—
0
0
231
1901
1.41
3.43
4.2
3.5
0.00
0.00
estimate
0.50
58
391
59
898
0.61
3.19
4.1
3.3
—
—
—
0
0
232
1932
1.38
3.11
4.2
3.5
0.00
0.00
estimate
-0.00
55
345
229
1906
1.38
3.07
5.6
4.7
0.00
0.00
estimate
-0.00
56
364
340
3024
1.41
3.02
8.8
7.4
74.84
78.06
u/l
0.75
330
2833
265
2270
1.37
2.91
9.6
8.9
4.29
4.08
e9/l
0.68
251
1996
13
47
2.81
2.83
1.5
1.9
31.15
33.00
pg
0.81
13
47
17
71
2.44
2.83
1.8
1.3
—
—
—
0
0
18
78
2.36
2.78
1.8
1.2
1.77
12.60
e6/l
0.66
13
60
223
1872
1.35
2.74
7.2
6.9
1.21
1.21
mmol/l
0.42
191
1607
65
438
1.56
2.65
5.4
9.0
2.16
0.99
mmol/l
2.01
51
357
447
4227
1.67
2.62
12.0
10.1
29.24
27.15
u/l
0.86
440
4081
182
1489
1.35
2.62
3.6
3.6
45.24
38.49
ng/l
0.20
113
1034
16
68
2.40
2.58
3.0
2.2
13.96
15.93
%
—
10
32
120
1526
0.72
2.57
1.8
2.1
—
—
—
0
0
91
1212
0.69
2.55
3.1
2.4
—
—
—
0
0
19
88
2.21
2.54
1.7
1.5
—
—
—
0
0
464
4440
1.88
2.51
23.5
19.9
251.47
247.36
e9/l
0.66
459
4326
424
3971
1.51
2.48
16.8
13.7
28.96
23.28
mg/l
2.15
368
3119
464
4442
1.87
2.47
23.5
20.0
52.16
40.52
%
0.48
392
4165
138
1093
1.37
2.41
3.6
3.2
1496.46
175.58
mg/l
1.12
97
721
9
28
3.25
2.31
1.2
1.3
12155.56
19519.11
e6/l
—
9
19
63
436
1.51
2.29
3.1
2.6
1.64
1.80
%
0.54
63
399
143
1150
1.34
2.25
2.5
2.1
227.92
268.65
u/l
0.15
134
1084
175
1451
1.32
2.23
3.2
2.7
—
—
—
0
0
14
61
2.33
2.16
1.1
1.2
—
—
—
0
0
7
19
3.72
2.16
1.3
1.4
—
—
—
0
0
215
1845
1.30
2.10
2.8
2.6
—
—
—
0
0
101
777
1.38
2.10
1.8
1.9
—
—
—
0
0
86
645
1.40
2.08
1.2
1.3
24.99
32.52
iu/ml
0.32
34
214
7
20
3.53
2.06
3.7
5.5
—
—
—
0
0
147
1201
1.32
2.06
3.2
3.1
7.99
7.86
mmol/l
0.14
133
1016
82
612
1.41
2.04
1.1
1.3
9.73
11.34
u/ml
0.07
27
235
142
1158
1.32
2.01
3.9
3.8
3.21
9.42
mg/mmol
3.01
97
745
7
21
3.37
1.97
1.3
4.5
—
—
—
0
0
9
33
2.76
1.94
2.6
2.2
1.71
1.16
e9/l
—
9
28
118
942
1.33
1.93
2.3
2.0
2.52
2.99
mg/l
1.41
110
802
436
4147
1.47
1.93
17.0
12.7
—
—
—
0
0
235
2056
1.28
1.93
7.0
6.3
11.31
11.38
umol/l
0.03
222
1942
87
663
1.38
1.92
1.6
1.7
1259.33
1152.22
nmol/l
0.58
76
509
14
65
2.19
1.89
3.4
2.2
—
—
—
0
0
20
352
0.55
1.89
4.9
4.4
—
—
—
0
0
18
94
1.95
1.82
1.3
1.2
—
3.01
—
0
14
168
1420
1.28
1.79
5.2
4.7
1.88
2.40
ug/l
1.06
162
1282
109
870
1.33
1.78
1.7
1.7
1.12
1.26
mg/l
0.24
93
665
180
1537
1.27
1.76
3.7
3.2
5.79
5.78
ph
0.01
14
107
6
18
3.36
1.75
1.3
1.8
513.00
880.28
u/ml
—
6
18
46
644
0.68
1.67
3.1
2.7
0.80
2.35
e6/l
3.12
27
326
19
323
0.57
1.62
3.8
3.1
—
—
—
0
0
192
1670
1.25
1.57
3.2
2.6
133.54
125.80
ug/l
0.18
177
1540
9
183
0.48
1.54
3.3
3.8
—
—
—
0
0
36
245
1.51
1.47
1.4
1.3
—
52.37
—
0
20
39
270
1.48
1.47
2.5
2.4
—
17.80
—
0
20
22
133
1.68
1.45
4.4
2.2
4873.22
3599.49
u/l
0.09
11
55
9
39
2.33
1.43
1.7
1.2
—
—
—
0
0
45
323
1.43
1.42
2.2
2.6
72.96
69.88
e9/l
0.17
39
248
11
211
0.51
1.42
6.6
10.7
23.82
24.52
mmol/l
0.62
11
206
6
139
0.42
1.41
1.3
1.6
—
—
—
0
0
9
40
2.27
1.40
1.1
1.3
—
—
—
0
0
7
29
2.43
1.39
2.7
1.2
—
—
—
0
0
5
123
0.40
1.38
3.4
2.0
95.20
284.05
ug/l
—
5
116
6
23
2.63
1.37
1.0
1.7
10.33
8.91
mmol/l
—
6
23
401
3816
1.28
1.32
4.3
4.4
5.94
5.97
mmol/l
0.12
383
3493
9
43
2.11
1.31
2.2
2.7
—
—
—
0
0
5
18
2.80
1.29
1.0
1.2
—
—
—
0
0
10
48
2.11
1.28
1.4
2.1
—
—
—
0
0
35
487
0.70
1.26
1.2
1.3
—
—
—
0
0
38
521
0.71
1.26
1.4
1.2
—
—
—
0
0
315
2928
1.21
1.25
4.1
3.7
14.70
14.77
pmol/l
0.21
300
2640
13
70
1.88
1.25
4.0
2.4
—
—
—
0
0
51
386
1.36
1.21
1.4
1.5
—
—
—
0
0
32
223
1.47
1.20
1.3
1.2
—
—
—
0
0
6
26
2.32
1.19
3.3
2.2
728.33
615.90
e6/l
—
6
21
6
26
2.32
1.19
1.0
1.3
—
—
—
0
0
0
33
0.00
1.16
0.0
2.4
—
—
—
0
0
5
113
0.44
1.14
1.6
2.9
—
—
—
0
0
7
32
2.20
1.08
1.0
1.2
—
—
—
0
0
12
67
1.81
1.05
4.7
2.3
—
—
—
0
0
39
293
1.36
1.00
1.2
1.2
—
—
—
0
0
0
29
0.00
0.98
0.0
14.0
—
891.83
—
0
29
0
29
0.00
0.98
0.0
17.3
—
1565.79
—
0
29
10
54
1.87
0.97
2.3
3.1
—
—
—
0
0
23
327
0.69
0.96
5.9
8.4
—
—
—
0
0
11
62
1.79
0.95
1.2
1.2
61.87
12.43
u/l
0.51
11
54
104
892
1.21
0.94
1.7
1.5
18.95
20.52
nmol/l
0.64
97
754
6
27
2.24
0.93
1.3
3.8
—
—
—
0
0
13
78
1.68
0.92
1.6
1.5
18876.00
18954.81
e6/l
0.00
13
58
101
869
1.20
0.89
1.2
1.2
1.10
1.76
u/ml
0.61
29
245
402
3874
1.21
0.87
4.3
4.2
1.43
1.44
mmol/l
0.18
390
3584
8
43
1.87
0.87
2.1
1.5
11.52
16.34
ug/l
—
8
43
42
327
1.31
0.87
5.3
3.5
—
—
—
0
0
26
353
0.72
0.85
4.0
7.3
1.26
1.39
mmol/l
0.51
26
344
57
464
1.26
0.84
3.0
3.0
5.53
8.84
umol/l
1.74
50
410
6
31
1.95
0.84
2.0
2.3
648.50
561.88
ml
—
6
17
6
32
1.89
0.82
1.0
1.3
242.17
171.84
pmol/l
—
6
32
66
549
1.23
0.82
2.5
2.2
2.46
2.33
g/l
1.25
61
512
92
1061
0.84
0.81
3.9
2.8
—
—
—
0
0
374
3591
1.18
0.80
5.0
4.4
1.91
1.89
mu/l
0.13
362
3275
11
174
0.62
0.78
1.0
1.1
—
—
—
0
0
403
3898
1.19
0.76
4.6
4.3
4.64
4.63
mmol/l
0.03
390
3628
96
1092
0.85
0.72
4.1
2.9
0.14
0.47
e6/l
3.46
82
794
10
60
1.68
0.72
2.4
3.0
—
—
—
0
0
12
181
0.65
0.70
2.1
2.2
0.64
0.64
%
0.01
12
181
13
85
1.54
0.69
1.2
1.1
—
—
—
0
0
5
27
1.86
0.68
1.4
1.1
373.40
373.67
nmol/l
—
5
21
5
93
0.53
0.67
1.0
1.3
—
—
—
0
0
5
29
1.73
0.64
1.4
1.7
141.80
75.90
umol/l
—
5
29
11
71
1.56
0.62
4.1
1.6
—
—
—
0
0
5
30
1.67
0.61
1.2
2.1
38.40
36.40
%
—
5
30
8
50
1.61
0.61
5.8
7.8
10.25
11.20
mg/l
—
8
45
373
3607
1.14
0.61
5.8
5.6
40.56
39.99
mmol/mol
0.55
362
3370
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.6
—
—
—
0
0
284
2702
1.12
0.60
3.5
3.2
46.54
51.54
u/l
0.50
266
2539
408
3971
1.17
0.60
4.9
4.8
2.78
2.75
mmol/l
0.19
392
3673
125
1132
1.14
0.60
4.8
3.7
7.39
7.40
ph
0.31
37
201
10
64
1.57
0.59
3.7
2.9
3.26
4.49
e9/l
—
10
64
12
173
0.69
0.58
2.1
2.0
—
—
—
0
0
12
173
0.69
0.58
2.0
2.0
—
—
—
0
0
12
172
0.69
0.57
2.1
2.0
—
—
—
0
0
12
172
0.69
0.57
1.9
1.8
—
—
—
0
0
25
194
1.30
0.57
2.5
2.4
—
—
—
0
0
11
160
0.68
0.56
2.2
1.7
—
—
—
0
0
11
160
0.68
0.56
2.1
2.1
—
—
—
0
0
6
37
1.63
0.55
2.3
1.5
1.10
1.29
promille
—
6
26
384
3729
1.14
0.55
4.0
3.9
1.27
1.30
mmol/l
0.39
370
3435
11
159
0.68
0.55
1.5
1.2
—
—
—
0
0
53
452
1.19
0.55
1.5
1.6
—
—
—
0
0
37
304
1.23
0.55
1.7
1.5
—
—
—
0
0
10
147
0.67
0.54
3.0
3.4
0.66
0.19
g/l
—
5
57
169
1574
1.11
0.51
2.4
2.2
79.66
76.35
nmol/l
0.73
159
1404
10
67
1.50
0.50
3.7
3.1
55.80
57.78
%
—
10
67
7
45
1.56
0.49
1.0
1.4
—
—
—
0
0
50
430
1.18
0.48
1.3
1.6
—
—
—
0
0
7
46
1.53
0.48
1.0
1.1
—
—
—
0
0
7
46
1.53
0.48
1.4
1.2
—
—
—
0
0
14
103
1.37
0.45
3.8
4.3
—
—
—
0
0
27
329
0.81
0.45
1.5
1.4
—
—
—
0
0
10
140
0.71
0.44
2.2
2.1
—
—
—
0
0
6
91
0.66
0.42
1.5
1.5
—
—
—
0
0
55
483
1.16
0.42
1.8
1.6
—
—
—
0
0
5
32
1.57
0.42
1.0
1.2
—
—
—
0
0
41
352
1.18
0.42
3.8
3.4
1.53
1.96
mmol/l
0.39
34
285
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
3.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
227.57
—
0
18
13
97
1.35
0.40
2.2
1.9
3.18
4.32
iu/l
—
5
31
5
35
1.43
0.39
1.2
1.1
—
—
—
0
0
45
392
1.16
0.39
2.8
4.5
3.95
41.53
ug/l
1.15
38
334
15
192
0.77
0.38
1.2
1.1
—
95.86
—
0
7
5
36
1.39
0.38
2.8
2.6
—
—
—
0
0
5
36
1.39
0.38
4.0
1.4
—
—
—
0
0
101
1093
0.90
0.38
4.5
4.0
—
—
—
0
0
8
114
0.70
0.37
1.1
1.2
—
—
—
0
0
111
1031
1.10
0.36
5.0
3.7
0.00
0.01
estimate
0.69
55
352
28
236
1.20
0.35
1.3
1.2
—
—
—
0
0
9
124
0.72
0.35
27.4
11.0
—
—
—
0
0
129
1210
1.09
0.34
4.3
3.0
29.07
109.97
e6/l
0.82
116
902
7
97
0.72
0.31
2.9
3.5
32.43
35.62
umol/l
—
7
88
183
1751
1.07
0.29
14.7
9.1
0.00
0.00
e9/l
0.15
167
1431
22
258
0.85
0.28
1.9
2.7
—
—
—
0
0
84
781
1.09
0.28
1.6
1.4
2.52
2.46
g/l
0.13
64
493
77
830
0.91
0.28
2.2
2.9
0.60
0.78
ug/l
1.75
49
534
9
116
0.77
0.27
1.2
1.1
—
—
—
0
0
9
120
0.75
0.27
2.2
3.2
—
—
—
0
0
45
407
1.12
0.25
1.4
1.3
—
—
—
0
0
159
1523
1.07
0.25
2.1
1.9
95.78
95.34
pmol/l
0.04
89
785
6
83
0.72
0.24
2.7
2.8
—
—
—
0
0
177
1704
1.06
0.23
6.0
6.0
1.20
1.21
mmol/l
0.95
168
1565
105
995
1.07
0.22
3.7
2.7
356.77
6480.79
umol/l
3.76
99
866
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
115
1094
1.07
0.22
3.1
3.0
1596.82
1265.72
ng/l
0.27
103
925
57
527
1.09
0.22
2.7
2.2
18.87
23.94
%
1.94
40
455
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
—
—
0
0
0
10
0.00
0.21
0.0
6.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
18
154
1.18
0.21
1.1
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
5
43
1.16
0.21
1.2
1.3
—
—
—
0
0
6
48
1.25
0.20
1.2
1.9
—
—
—
0
0
67
630
1.07
0.18
1.7
1.6
—
—
—
0
0
51
475
1.08
0.17
1.5
1.4
—
—
—
0
0
12
141
0.85
0.16
4.3
4.5
—
—
—
0
0
36
389
0.92
0.15
1.6
1.4
—
—
—
0
0
8
99
0.80
0.13
2.0
1.8
163.25
226.83
pmol/l
—
8
92
13
113
1.15
0.13
1.0
1.2
106.00
53.33
titre
—
5
9
64
611
1.05
0.12
5.5
3.3
0.82
0.82
mmol/l
0.02
59
573
23
250
0.92
0.11
3.0
3.6
7.41
7.41
ph
—
7
29
129
1257
1.04
0.10
3.8
3.3
2.34
2.35
mmol/l
0.26
120
1114
5
48
1.04
0.09
2.6
3.2
2.88
3.49
nmol/l
—
5
48
29
272
1.07
0.09
1.6
1.4
—
—
—
0
0
21
194
1.09
0.09
3.7
3.4
—
—
—
0
0
111
1137
0.97
0.08
1.5
1.5
—
—
—
0
0
43
411
1.05
0.08
1.7
1.7
—
—
—
0
0
24
256
0.93
0.08
1.6
1.4
—
—
—
0
0
6
73
0.82
0.07
1.0
1.2
—
—
—
0
0
8
75
1.07
0.07
1.0
1.0
—
—
—
0
0
7
84
0.83
0.07
1.1
1.3
—
—
—
0
0
140
1380
1.02
0.05
4.6
3.5
38.61
103.20
e6/l
1.39
123
948
109
1072
1.02
0.05
2.0
1.6
1.47
1.40
mmol/l
0.39
97
903
48
489
0.98
0.02
2.5
2.2
134.10
114.90
ug/g
0.15
40
392
10
107
0.93
0.02
1.1
1.1
—
—
—
0
0
15
143
1.05
0.01
3.1
2.7
—
—
—
0
0
45
442
1.02
0.01
1.2
1.3
—
—
—
0
0
18
176
1.02
0.00
1.3
1.7
—
—
—
0
0
25
249
1.00
0.00
1.4
1.2
219.70
154.78
iu/ml
0.29
11
100
0
8
0.00
-0.00
0.0
1.7
—
17.90
—
0
8
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
69
1.01
-0.00
1.0
1.0
—
—
—
0
0
8
80
1.00
-0.00
1.8
1.2
0.60
0.85
nmol/l
—
8
67
0
6
0.00
-0.00
0.0
1.0
—
0.14
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
41.67
—
0
6
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
1.66
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
4.33
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
8.23
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
66.43
—
0
6
6
69
0.87
-0.00
1.2
1.1
—
5.82
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
18.93
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
5.16
—
0
7
7
78
0.90
-0.00
3.3
2.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_TULARAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
AB1_TULARAEMIA 0.971 [0.78, 1.21] 0.798
Birth year 0.996 [0.99, 1.0] 0.411

During the follow-up period (1.1.1998 — 31.12.2019), 131 out of 1400 females with AB1_TULARAEMIA died.

Males

Parameter HR [95% CI] p-value
AB1_TULARAEMIA 0.804 [0.68, 0.95] 0.011
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 193 out of 1871 males with AB1_TULARAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have AB1_TULARAEMIA.

N-year risk Females Males
1 0.079% 0.134%
5 0.564% 0.855%
10 1.485% 2.14%
15 2.888% 4.126%
20 4.936% 7.341%

Relationships between endpoints

Index endpoint: AB1_TULARAEMIA – Tularaemia

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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