Tularaemia

AB1_TULARAEMIA

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A21
  • Hospital discharge: ICD-9 02[1]
  • Hospital discharge: ICD-8 02[1]
  • Cause of death: ICD-10 A21
  • Cause of death: ICD-9 02[1]
  • Cause of death: ICD-8 02[1]

2 out of 7 registries used, show all original rules.

459

4. Check minimum number of events

None

459

5. Include endpoints

None

459

6. Filter based on genotype QC (FinnGen only)

459

Control definitions (FinnGen only)

Control exclude
AB1_ZOONOTIC_BACTERIAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4460 1976 2467
Only index persons 4103 1830 2273
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.07
Only index persons 0.08 0.07 0.09
Median age at first event (years)
Whole population 46.83 48.39 45.50
Only index persons 46.01 47.63 44.71

-FinnGen-

Key figures

All Female Male
Number of individuals 459 219 240
Unadjusted period prevalence (%) 0.09 0.07 0.11
Median age at first event (years) 50.58 47.45 53.43

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
404
Matched controls
4040
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A21.9
ICD-10 Finland
Tularaemia, unspecified
3920.1
223.6
195
*
A21.0
ICD-10 Finland
Ulceroglandular tularaemia
1446.8
115.6
107
*
J01MA02
ATC
ciprofloxacin; systemic
5.3
53.9
262
1041
A21.2
ICD-10 Finland
Pulmonary tularaemia
+∞
25.3
24
*
R50.9
ICD-10 Finland
Fever, unspecified
3.8
21.4
101
322
A21.8
ICD-10 Finland
Other forms of tularaemia
+∞
17.8
17
*
0210A
ICD-9 Finland
Tularaemia, Ulceroglandular tularaemia
+∞
15.7
15
*
02100
ICD-8 Finland
Tularaemia, Glanduraris sive ulceroglandularis
+∞
12.6
12
*
A21
ICD-10 Finland
Tularaemia
+∞
11.5
11
*
0219X
ICD-9 Finland
Tularaemia, Unspecified tularaemia
+∞
10.5
10
*
0218X
ICD-9 Finland
Tularaemia, Other specified tularaemia
+∞
10.5
10
*
A98.5
ICD-10 Finland
Haemorrhagic fever with renal syndrome
8.2
10.2
22
28
J17.0*A21.2
ICD-10 Finland
Pneumonia (due to)(in) tularaemia
+∞
9.4
9
*
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
5.6
8.0
22
41
SPAT1263
SPAT
Sampling
1.8
7.9
177
1198
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
7.6
54
221
A21.7
ICD-10 Finland
Generalized tularaemia
+∞
7.3
7
*
WX704
NOMESCO Finland
Intubation
3.3
7.2
35
113
SPAT1324
SPAT
Screening procedure
2.2
6.4
63
308
02107
ICD-8 Finland
Tularaemia, Suspecta
+∞
6.3
6
*
02109
ICD-8 Finland
Tularaemia, Unspecified
+∞
6.3
6
*
B99
ICD-10 Finland
Other and unspecified infectious diseases
6.4
6.2
15
24
SPAT1044
SPAT
Tympanometry
5.7
6.1
16
29

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
161
989
1.97
10.19
3.9
4.3
—
—
—
0
0
19
37
5.31
9.44
1.3
1.1
—
—
—
0
0
152
989
1.80
7.65
4.1
3.2
—
—
—
0
0
56
258
2.33
7.33
5.2
4.6
0.0
0.1
%
0.66
13
77
23
65
3.67
7.24
2.5
1.3
—
—
—
0
0
56
265
2.27
6.89
4.5
4.5
1.3
0.3
%
0.95
12
69
127
805
1.80
6.87
5.3
4.4
—
—
—
0
0
57
275
2.22
6.70
4.5
4.6
0.1
0.2
%
0.64
16
88
45
196
2.44
6.67
4.1
2.7
0.4
0.2
e6/l
0.47
45
190
112
691
1.82
6.59
5.3
3.6
148.2
203.1
ng/l
0.24
88
532
59
296
2.14
6.29
5.1
4.4
2.4
0.8
%
0.73
16
98
115
736
1.75
5.92
1.8
1.7
425.3
6452052.4
pmol/l
0.50
104
620
225
1724
1.60
5.71
6.7
5.6
2.8
2.8
%
0.11
219
1610
241
1879
1.60
5.67
6.6
5.7
0.2
0.2
e9/l
0.32
227
1659
230
1776
1.59
5.62
6.7
5.8
27.8
27.8
%
0.03
224
1665
227
1749
1.59
5.59
6.4
5.5
57.0
57.3
%
0.19
221
1652
239
1869
1.58
5.48
6.3
5.5
1.8
2.0
e9/l
1.12
222
1660
161
1152
1.61
5.35
2.9
2.6
56.5
57.2
u/l
0.12
153
1065
42
198
2.23
5.23
6.5
12.7
—
—
—
0
0
202
1540
1.56
5.05
6.3
4.6
35.7
35.8
g/l
0.04
188
1440
230
1819
1.53
4.79
6.4
5.4
0.6
0.6
e9/l
1.18
217
1582
230
1826
1.52
4.66
6.4
5.4
0.0
0.0
e9/l
0.46
217
1597
263
2160
1.51
4.46
5.0
4.9
6.8
6.7
mmol/l
0.14
246
2005
412
3785
1.86
4.04
17.1
15.9
139.4
139.7
mmol/l
1.35
405
3676
293
2488
1.49
4.03
5.6
4.2
—
—
—
0
0
314
2707
1.51
3.98
5.6
4.0
13.4
11.5
mm/h
1.34
306
2487
22
88
2.58
3.94
3.4
4.2
22.1
24.9
mg/l
0.11
16
58
141
1038
1.52
3.94
3.2
3.0
—
—
—
0
0
14
43
3.33
3.94
2.9
2.2
13.1
13.2
%
0.13
14
43
43
231
1.95
3.84
5.9
6.3
—
—
—
0
0
412
3798
1.83
3.81
17.8
16.0
4.0
4.0
mmol/l
1.30
405
3686
43
238
1.89
3.53
2.3
2.3
—
—
—
0
0
28
132
2.19
3.53
1.1
1.3
—
—
—
0
0
298
2572
1.45
3.53
4.0
3.7
—
—
—
0
0
186
1474
1.44
3.51
9.7
8.4
1.2
1.2
inr
0.23
57
425
19
76
2.56
3.42
5.1
4.0
—
—
—
0
0
59
908
0.60
3.39
10.7
6.6
—
—
—
0
0
13
44
3.01
3.16
1.5
1.5
—
—
—
0
0
13
44
3.01
3.16
1.5
1.5
—
—
—
0
0
13
44
3.01
3.16
1.5
1.5
—
—
—
0
0
13
44
3.01
3.16
1.5
1.5
—
—
—
0
0
279
2405
1.41
3.15
5.4
4.2
861.5
1885.0
e6/l
0.25
17
42
10
29
3.50
3.06
1.1
1.0
—
—
—
0
0
19
82
2.37
2.95
1.2
1.3
—
—
—
0
0
77
528
1.55
2.92
1.8
2.1
—
—
—
0
0
212
1766
1.37
2.83
4.2
3.5
0.0
0.0
estimate
0.00
56
337
20
91
2.25
2.77
3.3
2.2
25.6
24.5
mmol/l
0.27
15
77
56
828
0.63
2.68
4.0
3.3
—
—
—
0
0
16
67
2.44
2.66
1.8
1.3
—
—
—
0
0
318
2846
1.38
2.60
8.8
7.5
75.4
78.0
u/l
0.53
308
2667
12
44
2.77
2.56
1.5
1.9
30.9
33.2
pg
1.02
12
44
69
479
1.52
2.48
1.2
1.3
229.3
517.0
titre
2.66
15
105
213
1801
1.34
2.48
4.2
3.5
0.0
0.0
estimate
0.00
54
322
172
1409
1.35
2.47
3.7
3.6
45.5
38.1
ng/l
0.21
108
982
210
1776
1.34
2.43
5.5
4.8
0.0
0.0
estimate
0.00
55
343
15
64
2.39
2.41
3.1
2.3
14.1
15.9
%
—
9
31
7
17
4.16
2.37
1.3
1.1
—
—
—
0
0
17
78
2.22
2.34
1.1
1.3
282.0
269.8
u/ml
—
9
42
245
2129
1.32
2.31
9.8
8.8
4.3
4.1
e9/l
0.49
232
1870
114
1436
0.73
2.30
1.8
2.1
—
—
—
0
0
165
1356
1.34
2.29
3.2
2.8
—
—
—
0
0
205
1739
1.32
2.28
5.0
4.0
—
—
—
0
0
434
4154
1.82
2.28
23.7
20.0
250.5
246.9
e9/l
0.52
429
4047
104
798
1.39
2.22
3.9
3.7
1.0
1.0
kg/l
0.04
22
108
8
199
0.39
2.21
5.8
10.9
23.9
24.4
mmol/l
—
8
186
417
3957
1.59
2.18
12.0
10.1
28.7
26.9
u/l
0.63
410
3817
7
19
3.72
2.16
3.7
5.2
—
—
—
0
0
396
3726
1.46
2.06
16.9
13.8
26.5
23.3
mg/l
0.90
340
2930
205
1758
1.30
2.05
7.3
6.9
1.2
1.2
mmol/l
0.20
172
1497
17
83
2.09
2.03
1.8
1.5
—
—
—
0
0
59
415
1.48
2.01
3.2
2.6
1.7
1.8
%
0.37
59
379
7
21
3.37
1.97
1.3
4.5
—
—
—
0
0
128
1034
1.33
1.96
3.7
3.2
1594.1
182.2
mg/l
1.12
91
680
58
410
1.47
1.94
5.3
9.2
2.3
0.9
mmol/l
2.30
47
330
112
891
1.34
1.90
2.3
2.0
2.6
3.0
mg/l
1.09
104
755
90
1145
0.73
1.88
3.1
2.4
—
—
—
0
0
8
28
2.89
1.87
1.3
1.3
12975.0
19519.1
e6/l
—
8
19
182
1562
1.27
1.74
3.2
2.6
138.7
127.9
ug/l
0.25
167
1438
131
1079
1.30
1.73
2.6
2.1
238.5
274.1
u/l
0.12
123
1017
20
338
0.57
1.67
4.9
4.5
—
—
—
0
0
145
1217
1.28
1.65
7.0
5.5
—
—
—
0
0
136
1133
1.28
1.64
3.3
3.1
8.1
7.9
mmol/l
0.15
122
943
132
1097
1.29
1.62
4.1
4.0
3.3
9.0
mg/mmol
2.51
90
712
219
1937
1.25
1.59
7.0
6.3
11.6
11.4
umol/l
0.06
206
1828
13
64
2.06
1.55
3.5
2.1
—
—
—
0
0
74
572
1.35
1.52
1.1
1.3
10.8
12.1
u/ml
0.05
24
219
81
635
1.33
1.51
1.6
1.7
1298.5
1148.6
nmol/l
0.85
70
489
18
304
0.58
1.51
4.0
3.0
—
—
—
0
0
21
124
1.73
1.50
4.6
2.2
4873.2
3867.7
u/l
0.07
11
51
9
37
2.46
1.48
1.7
1.2
—
—
—
0
0
9
37
2.46
1.48
1.1
1.4
—
—
—
0
0
378
3578
1.32
1.47
4.3
4.4
5.9
6.0
mmol/l
0.25
361
3271
77
602
1.34
1.47
1.2
1.3
28.2
33.9
iu/ml
0.18
27
198
159
1366
1.25
1.47
5.1
4.8
2.0
2.4
ug/l
0.94
153
1232
12
59
2.06
1.44
1.2
1.2
—
—
—
0
0
9
40
2.27
1.41
2.2
2.7
—
—
—
0
0
100
817
1.29
1.39
1.8
1.7
1.1
1.3
mg/l
0.28
86
623
8
163
0.48
1.38
1.0
1.0
—
—
—
0
0
297
2743
1.23
1.36
4.3
3.7
14.8
14.8
pmol/l
0.05
282
2465
90
728
1.29
1.35
1.9
1.9
—
—
—
0
0
82
1011
0.77
1.35
4.2
2.8
—
—
—
0
0
13
68
1.94
1.34
4.0
2.4
—
—
—
0
0
406
3895
1.37
1.34
17.3
12.8
—
—
—
0
0
9
175
0.50
1.31
3.3
3.9
—
—
—
0
0
12
63
1.93
1.24
4.7
2.3
—
—
—
0
0
42
307
1.41
1.23
2.3
2.6
75.1
69.4
e9/l
0.34
37
237
10
49
2.06
1.23
2.3
3.0
—
—
—
0
0
31
215
1.47
1.19
1.3
1.3
—
—
—
0
0
47
353
1.37
1.18
1.4
1.5
—
—
—
0
0
379
3617
1.27
1.18
4.3
4.3
1.4
1.4
mmol/l
0.21
367
3338
6
130
0.45
1.17
1.3
1.6
—
—
—
0
0
22
330
0.65
1.17
3.4
7.5
1.2
1.4
mmol/l
0.80
22
315
35
250
1.43
1.16
2.5
2.4
—
14.8
—
0
14
0
33
0.00
1.16
0.0
2.4
—
—
—
0
0
15
87
1.75
1.16
1.2
1.2
—
2.7
—
0
12
5
111
0.44
1.14
1.8
3.0
—
—
—
0
0
32
226
1.45
1.13
1.4
1.3
—
41.9
—
0
15
100
840
1.24
1.11
1.7
1.5
19.1
20.6
nmol/l
0.58
93
708
7
31
2.28
1.10
1.0
1.2
—
—
—
0
0
8
41
1.97
1.09
2.1
1.5
11.5
16.1
ug/l
—
8
41
41
307
1.37
1.06
5.4
3.5
—
—
—
0
0
380
3640
1.26
1.06
4.5
4.4
4.6
4.6
mmol/l
0.16
367
3381
21
307
0.67
1.01
5.2
8.7
—
—
—
0
0
37
277
1.37
0.97
1.2
1.1
—
—
—
0
0
38
496
0.75
0.96
1.4
1.2
—
—
—
0
0
35
461
0.74
0.94
1.2
1.3
—
—
—
0
0
6
27
2.24
0.93
1.3
3.8
—
—
—
0
0
89
1040
0.82
0.91
4.3
2.9
0.1
0.5
e6/l
4.11
76
750
6
29
2.08
0.89
3.0
1.2
—
—
—
0
0
6
30
2.01
0.87
1.0
1.3
—
39.5
—
0
8
6
30
2.01
0.87
2.2
2.3
648.5
561.9
ml
—
6
17
363
3485
1.20
0.84
4.0
3.9
1.3
1.3
mmol/l
0.36
349
3208
32
241
1.35
0.83
2.5
2.6
4.4
3.9
e9/l
0.60
26
189
384
3708
1.22
0.82
4.9
4.8
2.8
2.7
mmol/l
0.37
368
3420
95
823
1.19
0.79
1.2
1.2
1.1
1.2
u/ml
0.16
27
227
0
25
0.00
0.79
0.0
16.0
—
1416.4
—
0
25
0
25
0.00
0.79
0.0
13.3
—
850.0
—
0
25
10
59
1.71
0.76
3.7
2.9
3.3
4.5
e9/l
—
10
59
5
24
2.09
0.74
2.0
2.2
768.8
476.5
e6/l
—
5
19
10
60
1.68
0.72
1.2
1.2
67.8
12.0
u/l
—
10
52
62
521
1.22
0.71
2.6
2.2
2.5
2.3
g/l
1.19
57
485
5
26
1.93
0.71
1.0
1.3
—
—
—
0
0
5
26
1.93
0.71
1.4
1.2
373.4
373.7
nmol/l
—
5
21
7
42
1.68
0.68
2.0
2.3
—
—
—
0
0
7
43
1.64
0.67
1.4
1.3
—
—
—
0
0
13
86
1.53
0.66
2.2
1.7
3.2
4.7
iu/l
—
5
26
10
62
1.63
0.65
3.7
3.2
55.8
57.9
%
—
10
62
7
44
1.60
0.65
1.0
1.1
—
—
—
0
0
52
434
1.22
0.65
3.2
3.0
5.7
9.1
umol/l
1.65
45
386
108
963
1.16
0.65
4.9
3.7
0.0
0.0
estimate
0.69
54
332
5
29
1.73
0.64
1.2
2.1
—
32.6
—
0
5
6
103
0.58
0.62
1.2
1.2
—
—
—
0
0
45
373
1.23
0.61
2.8
4.6
4.0
42.9
ug/l
1.12
37
318
348
3361
1.15
0.60
5.1
4.4
1.9
1.9
mu/l
0.15
336
3049
8
52
1.55
0.59
2.8
2.8
—
—
—
0
0
35
283
1.26
0.59
1.7
1.5
—
—
—
0
0
11
161
0.68
0.58
2.2
1.6
—
—
—
0
0
11
161
0.68
0.58
2.1
1.6
—
—
—
0
0
24
185
1.31
0.57
2.5
2.4
—
—
—
0
0
28
221
1.28
0.57
1.3
1.2
—
—
—
0
0
5
87
0.57
0.56
1.4
1.4
—
—
—
0
0
11
160
0.68
0.56
2.0
1.6
—
—
—
0
0
11
160
0.68
0.56
2.2
1.6
—
—
—
0
0
5
90
0.55
0.56
1.0
1.3
—
—
—
0
0
10
148
0.67
0.56
2.2
1.6
—
—
—
0
0
12
170
0.70
0.54
2.1
2.3
0.6
0.7
%
0.10
12
165
49
416
1.20
0.53
1.6
1.6
—
—
—
0
0
116
1055
1.13
0.53
4.9
3.7
7.4
7.4
ph
0.25
36
186
10
145
0.68
0.51
3.1
3.3
0.7
0.2
g/l
—
5
57
47
400
1.19
0.51
1.3
1.7
—
—
—
0
0
12
84
1.44
0.49
1.2
1.1
—
—
—
0
0
11
76
1.46
0.48
1.7
1.5
16980.8
19628.9
e6/l
0.09
11
56
10
68
1.48
0.47
3.5
1.6
—
—
—
0
0
11
152
0.72
0.45
1.5
1.2
—
—
—
0
0
52
453
1.17
0.44
1.8
1.6
—
—
—
0
0
9
128
0.70
0.44
2.3
1.6
—
—
—
0
0
72
802
0.88
0.43
2.2
3.0
0.6
0.8
ug/l
1.72
47
521
176
1658
1.10
0.43
15.0
9.1
0.0
0.0
e9/l
0.15
160
1356
5
32
1.57
0.42
1.0
1.2
—
—
—
0
0
5
33
1.52
0.41
2.8
2.2
—
—
—
0
0
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
3.5
—
—
—
0
0
5
34
1.48
0.40
2.6
1.5
0.9
1.3
promille
—
5
24
0
18
0.00
0.40
0.0
1.2
—
227.6
—
0
18
347
3382
1.11
0.39
5.9
5.7
40.6
40.0
mmol/mol
0.55
336
3156
5
35
1.43
0.39
4.6
1.4
—
—
—
0
0
11
148
0.74
0.39
2.2
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
3.3
—
—
—
0
0
8
111
0.72
0.37
1.3
1.2
—
—
—
0
0
26
310
0.83
0.37
1.5
1.5
—
—
—
0
0
5
76
0.65
0.36
3.0
1.9
—
—
—
0
0
6
42
1.43
0.35
1.0
1.5
—
—
—
0
0
32
370
0.85
0.33
1.6
1.4
—
—
—
0
0
6
46
1.31
0.33
1.2
1.9
—
—
—
0
0
13
101
1.30
0.32
4.0
4.4
—
—
—
0
0
63
577
1.11
0.28
5.5
3.3
0.8
0.8
mmol/l
0.01
58
541
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
7
95
0.73
0.22
1.1
1.1
—
—
—
0
0
99
938
1.07
0.22
3.8
2.7
361.6
6427.5
umol/l
3.52
92
807
0
11
0.00
0.21
0.0
2.8
—
—
—
0
0
0
11
0.00
0.21
0.0
3.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
3.5
—
—
—
0
0
0
10
0.00
0.21
0.0
6.2
—
—
—
0
0
0
10
0.00
0.21
0.0
3.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
99
1041
0.94
0.20
4.5
4.1
—
—
—
0
0
9
114
0.79
0.20
27.4
10.5
—
—
—
0
0
11
132
0.83
0.18
4.6
4.3
—
—
—
0
0
78
739
1.07
0.18
1.6
1.3
2.6
2.5
g/l
0.13
59
460
22
247
0.89
0.17
1.9
2.8
—
—
—
0
0
8
71
1.13
0.16
1.0
1.0
—
—
—
0
0
149
1444
1.05
0.16
2.1
1.9
96.9
95.7
pmol/l
0.10
83
748
36
332
1.09
0.15
4.0
3.4
1.5
1.9
mmol/l
0.34
29
261
6
80
0.75
0.15
1.2
1.3
—
—
—
0
0
44
413
1.07
0.13
1.3
1.3
—
—
—
0
0
9
110
0.81
0.13
2.2
2.3
—
—
—
0
0
43
457
0.93
0.13
14.2
19.8
1.2
1.3
inr
0.44
19
62
62
592
1.05
0.12
1.7
1.6
—
—
—
0
0
163
1593
1.04
0.11
6.1
6.1
1.2
1.2
mmol/l
0.54
150
1450
22
240
0.91
0.11
3.1
3.6
7.4
7.4
ph
—
6
28
128
1315
0.96
0.11
4.9
3.6
40.7
106.9
e6/l
1.35
115
908
25
231
1.09
0.11
1.4
1.2
219.7
156.5
iu/ml
0.28
11
93
40
378
1.06
0.10
1.4
1.3
—
—
—
0
0
103
1001
1.04
0.10
1.8
1.6
1.4
1.4
mmol/l
0.35
91
840
5
45
1.11
0.10
2.6
3.3
2.9
3.7
nmol/l
—
5
45
41
389
1.06
0.09
1.7
1.7
—
—
—
0
0
347
3441
1.03
0.09
17.4
14.5
39.7
40.2
%
0.44
205
2537
21
227
0.92
0.09
1.7
1.4
—
—
—
0
0
14
126
1.11
0.09
1.4
1.3
33.2
24.1
iu/l
0.34
14
101
52
499
1.05
0.08
2.8
2.2
18.4
24.0
%
2.93
36
433
6
57
1.05
0.08
1.3
1.2
—
—
—
0
0
20
185
1.08
0.08
3.9
3.5
—
—
—
0
0
7
64
1.10
0.08
1.0
1.0
—
—
—
0
0
6
71
0.84
0.07
3.7
2.8
—
—
—
0
0
15
137
1.10
0.07
3.1
2.8
—
—
—
0
0
8
78
1.03
0.07
1.8
1.3
0.6
0.9
nmol/l
—
8
65
118
1159
1.02
0.06
4.6
3.0
30.4
113.1
e6/l
0.79
108
864
17
159
1.07
0.05
1.4
1.7
—
—
—
0
0
121
1192
1.02
0.05
3.7
3.2
2.3
2.4
mmol/l
0.16
111
1048
15
141
1.07
0.03
1.1
1.1
—
—
—
0
0
26
251
1.04
0.02
1.5
1.4
—
—
—
0
0
106
1072
0.99
0.02
1.5
1.5
—
—
—
0
0
24
244
0.98
0.00
3.0
3.6
5.4
5.1
kpa
0.68
19
222
45
446
1.01
0.00
1.6
1.4
—
—
—
0
0
46
464
0.99
0.00
2.6
2.3
134.1
115.3
ug/g
0.15
40
373
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
5.2
—
0
7
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
18.9
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
19.9
—
0
6
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
38.2
—
0
5
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
4.3
—
0
5
0
5
0.00
0.00
0.0
1.0
—
8.2
—
0
5
6
66
0.91
0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
1.7
—
0
8

Mortality – FinRegistry

Association

Association between endpoint AB1_TULARAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
AB1_TULARAEMIA 0.971 [0.78, 1.21] 0.798
Birth year 0.996 [0.99, 1.0] 0.411

During the follow-up period (1.1.1998 — 31.12.2019), 131 out of 1400 females with AB1_TULARAEMIA died.

Males

Parameter HR [95% CI] p-value
AB1_TULARAEMIA 0.804 [0.68, 0.95] 0.011
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 193 out of 1871 males with AB1_TULARAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have AB1_TULARAEMIA.

N-year risk Females Males
1 0.079% 0.134%
5 0.564% 0.855%
10 1.485% 2.14%
15 2.888% 4.126%
20 4.936% 7.341%

Relationships between endpoints

Index endpoint: AB1_TULARAEMIA – Tularaemia

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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