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Hereditary angioödema type 2

D3_ANGIOEDEMA_2

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D84.12
  • Cause of death: ICD-10 D84.12

2 out of 7 registries used, show all original rules.

14

4. Check minimum number of events

None

14

5. Include endpoints

None

14

6. Filter based on genotype QC (FinnGen only)

14

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 14 10 -
Unadjusted period prevalence (%) 0.00 0.00 -
Median age at first event (years) 49.44 48.65 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
6
28.11
5.96
2.4
1.3
0.2
0.3
g/l
—
8
6
7
7
18.17
4.61
2.6
1.3
1.4
1.4
g/l
—
7
7
7
34
3.09
1.26
2.9
2.7
—
—
—
0
0
5
23
2.80
0.87
1.4
3.5
—
—
—
0
0
5
24
2.66
0.85
4.0
4.1
—
—
—
0
0
8
50
2.39
0.83
3.9
2.6
—
—
—
0
0
6
37
2.08
0.66
1.2
1.4
—
—
—
0
0
14
120
+∞
0.66
13.4
11.6
41.8
40.2
%
—
6
100
8
53
2.18
0.60
3.7
3.4
—
—
—
0
0
5
30
2.03
0.51
4.4
4.1
—
1.0
—
0
5
5
36
1.60
0.28
2.2
3.3
8.3
25.4
e6/l
—
5
19
0
10
0.00
0.22
0.0
1.2
—
—
—
0
0
0
12
0.00
0.22
0.0
1.5
—
—
—
0
0
0
12
0.00
0.22
0.0
2.0
—
—
—
0
0
5
42
1.29
0.12
7.2
4.2
34.6
35.0
g/l
—
5
42
9
81
1.31
0.11
5.1
4.0
—
—
—
0
0
7
63
1.22
0.11
1.9
2.7
104.0
71.8
ug/l
—
7
57
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
7.1
—
0
8
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
6.2
—
1.0
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
6.0
—
—
—
0
0
0
6
0.00
0.00
0.0
5.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
9.3
—
88.5
—
0
7
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
105.5
—
0
7
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: D3_ANGIOEDEMA_2 – Hereditary angioödema type 2

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).