No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
412 |
6. Filter based on genotype QC (FinnGen only) |
394 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D80-D89
- Name in latin
- Aliae deficientiae immunales
Similar endpoints
↥List of similar endpoints to
Other immunodeficiencies
based on the number of shared cases.
Similar with more cases:
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2645 | 1656 | 973 |
| Only index persons | 2220 | 1431 | 789 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.03 |
| Only index persons | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 45.52 | 47.81 | 41.32 |
| Only index persons | 45.60 | 47.13 | 42.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 394 | 268 | 126 |
| Unadjusted period prevalence (%) | 0.08 | 0.10 | 0.06 |
| Median age at first event (years) | 48.01 | 46.11 | 52.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 412
- Matched controls
- 4120
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
129.1
117
*
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
112.8
103
*
T78.3
ICD-10 Finland
Angioneurotic oedema
42.7
110.8
68
19
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
14.0
85.6
86
76
D84.1
ICD-10 Finland
Defects in the complement system
+∞
79.8
74
*
D84.19
ICD-10 Finland
Unspecified defect in the complement system
+∞
70.9
66
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.0
62.5
68
67
WW200
NOMESCO Finland
Immunization
17.6
59.0
50
32
H02AB06
ATC
prednisolone; systemic
5.5
58.0
297
1317
ZX120
NOMESCO Finland
Intravenous
6.7
55.4
105
201
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.7
51.4
270
1185
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
11.1
50.4
57
59
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
6.7
49.0
90
166
TDM10
NOMESCO Finland
Puncture of maxillary antrum
9.6
48.8
62
75
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
14.7
48.4
45
34
R03DC03
ATC
montelukast; oral
4.7
47.1
148
437
D84.8
ICD-10 Finland
Other specified immunodeficiencies
+∞
46.8
44
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
45.7
43
*
H02AB07
ATC
prednisone; oral
5.3
45.2
111
267
C01CA24
ATC
epinephrine; parenteral
6.2
44.9
89
176
J01MA14
ATC
moxifloxacin; systemic
6.2
44.7
88
173
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.1
43.4
188
698
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
42.4
40
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.4
41.8
66
103
J01MA12
ATC
levofloxacin; systemic
4.5
41.4
132
390
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
41.3
39
*
D84.11
ICD-10 Finland
Hereditary angioedema type I
+∞
40.3
38
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
40.3
38
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.0
38.3
149
506
J45.9
ICD-10 Finland
Asthma, unspecified
4.1
38.2
144
478
J45.0
ICD-10 Finland
Predominantly allergic asthma
5.1
37.3
92
220
XQ800
NOMESCO Finland
Prick test
5.5
37.1
83
182
D84.13
ICD-10 Finland
Hereditary angioedema type III
+∞
37.0
35
*
D84.0
ICD-10 Finland
Lymphocyte function antigen-1 [LFA-1] defect
+∞
36.0
34
*
338
Kela drug reimbursment
C1-esterase inhibitor, icatibant and conestat alfa
+∞
36.0
34
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
36.0
34
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.9
35.7
143
493
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.4
35.0
109
313
B06AC02
ATC
icatibant; parenteral
+∞
33.8
32
*
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
6.5
32.9
58
101
J45.1
ICD-10 Finland
Nonallergic asthma
5.2
32.6
75
168
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
6.0
32.4
63
121
UJF32
NOMESCO Finland
Coloscopy
3.6
31.8
151
576
H02AB04
ATC
methylprednisolone; systemic
4.2
30.8
101
299
UDH02
NOMESCO Finland
Rhinopharyngoscopy
5.2
29.9
68
150
R03BB04
ATC
tiotropium bromide; inhalant
5.1
29.8
69
155
J45.8
ICD-10 Finland
Mixed asthma
9.0
29.6
38
46
H02AB09
ATC
hydrocortisone; systemic
8.7
29.5
39
49
UJF30
NOMESCO Finland
Ileoscopy through colon
4.6
27.8
74
186
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.4
27.7
136
524
J01FF01
ATC
clindamycin; systemic
3.2
27.7
160
680
TGC00
NOMESCO Finland
Bronchial lavation
11.1
27.4
30
29
R50.9
ICD-10 Finland
Fever, unspecified
3.6
27.2
113
391
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
26.3
25
*
UJF92
NOMESCO Finland
Capsular endoscopy
10.7
25.9
29
29
Z01.8
ICD-10 Finland
Other specified special examinations
3.2
25.5
136
547
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
25.5
172
792
X59
ICD-10 Finland
Exposure to unspecified factor
3.3
25.2
124
475
J31.0
ICD-10 Finland
Chronic rhinitis
4.3
25.2
75
205
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.6
24.9
100
337
B02AA02
ATC
tranexamic acid; systemic
3.4
24.3
112
411
J01MA02
ATC
ciprofloxacin; systemic
2.9
24.1
190
946
R60.9
ICD-10 Finland
Oedema, unspecified
5.8
23.3
45
85
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.8
22.3
55
129
R03DA04
ATC
theophylline; systemic, rectal
6.3
22.2
39
67
R03AK08
ATC
formoterol and beclometasone; inhalant
5.8
21.8
42
79
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
21.6
203
1091
6BA02, ,
NOMESCO Finland
53.0
21.4
25
5
Z31.5
ICD-10 Finland
Genetic counselling
4.3
21.0
60
158
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.0
20.9
67
192
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.0
20.8
65
183
J47
ICD-10 Finland
Bronchiectasis
18.5
20.3
31
18
R06.0
ICD-10 Finland
Dyspnoea
2.8
20.3
139
632
R03AC02
ATC
salbutamol; inhalant
2.8
20.2
288
1876
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
6.1
19.8
36
64
R03AC12
ATC
salmeterol; inhalant
5.6
19.8
39
75
J45
ICD-10 Finland
Asthma
3.7
19.8
70
215
R03AK07
ATC
formoterol and budesonide; inhalant
2.9
19.7
123
531
Z3231
NOMESCO Finland
Registered nurse
2.7
19.7
161
799
J46
ICD-10 Finland
Status asthmaticus
8.0
19.3
27
36
J01FA06
ATC
roxithromycin; oral
2.6
19.2
199
1103
XG410
NOMESCO Finland
Flow-volume spirometry
6.1
18.8
34
60
A07AA02
ATC
nystatin; oral
4.9
18.7
44
99
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.9
18.7
43
95
R06AE09
ATC
levocetirizine; oral
3.0
18.6
98
384
R06AE07
ATC
cetirizine; oral
2.5
18.4
227
1357
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
6.7
18.3
30
48
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.8
18.1
60
176
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.7
17.9
63
192
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.6
17.8
145
713
A02BC01
ATC
omeprazole; systemic
2.6
17.5
140
681
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.4
17.5
69
227
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
17.4
182
1003
R06AX27
ATC
desloratadine; oral
2.5
17.3
169
902
Z2221
NOMESCO Finland
Medical doctor
2.5
17.2
158
820
XF400
NOMESCO Finland
ECG with 12 standard connections
3.0
17.1
89
345
R03BA08
ATC
ciclesonide; inhalant
3.6
17.0
61
188
Z3226
NOMESCO Finland
Physiotherapist
2.7
17.0
114
507
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.3
17.0
71
242
R01AD08
ATC
fluticasone; nasal
2.5
16.9
158
825
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.9
16.7
38
83
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.6
16.6
41
96
R03BA02
ATC
budesonide; inhalant
2.7
16.4
108
475
R60.0
ICD-10 Finland
Localized oedema
3.3
16.3
68
231
WZC30
NOMESCO Finland
Teaching
2.9
16.1
90
363
A02BC02
ATC
pantoprazole; systemic
2.5
16.1
288
1989
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
15.9
141
715
N03AX16
ATC
[U] pregabalin
2.6
15.8
117
545
B06AC05
ATC
lanadelumab; parenteral
+∞
15.7
15
*
D84.12
ICD-10 Finland
Hereditary angioedema type II
+∞
15.7
15
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
15.6
188
1089
ZXA10
NOMESCO Finland
Bilateral
2.7
15.6
104
459
C03CA01
ATC
furosemide; systemic
2.6
15.5
117
549
T78.4
ICD-10 Finland
Allergy, unspecified
4.3
15.5
42
106
N02AX02
ATC
tramadol; systemic, rectal
2.3
15.4
190
1111
L04AX01
ATC
azathioprine; systemic
5.0
15.2
34
73
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.6
15.2
109
499
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.6
15.1
37
86
J32.4
ICD-10 Finland
Chronic pansinusitis
15.8
15.1
24
16
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
15.0
260
1745
Z2446
NOMESCO Finland
Social worker
3.4
15.0
59
193
R01AD09
ATC
mometasone; nasal
2.3
14.9
227
1444
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.2
14.8
41
105
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
14.8
81
322
L01BA01
ATC
methotrexate; systemic
5.7
14.7
28
52
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.7
14.6
92
393
ZXE00
NOMESCO Finland
One hour or less
2.3
14.6
196
1179
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.1
14.4
42
112
X57
ICD-10 Finland
Unspecified privation
6.1
14.2
25
43
A01AB09
ATC
miconazole; local oral
3.5
14.1
52
163
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.3
14.0
59
201
A02BC03
ATC
lansoprazole; oral
2.3
13.8
135
708
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.2
13.7
60
209
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
6.2
13.7
24
41
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.6
13.6
33
76
P01BA02
ATC
hydroxychloroquine; oral
3.4
13.6
52
167
L04AB04
ATC
adalimumab; parenteral
6.4
13.5
23
38
R03BA05
ATC
fluticasone; inhalant
2.4
13.4
114
561
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.7
13.3
32
73
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
5.7
13.2
25
46
A06AD11
ATC
lactulose; oral
2.9
13.1
69
267
SPAT1255
SPAT
Intravenous administration of medicine
4.1
13.1
37
96
N06AX21
ATC
duloxetine; oral
2.8
13.0
72
287
N02AA05
ATC
oxycodone; systemic
2.7
12.6
79
335
R03AC03
ATC
terbutaline; inhalant
2.7
12.6
76
316
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
5.3
12.6
26
52
B06AC01
ATC
c1-inhibitor, plasma derived; parenteral
+∞
12.6
12
*
R03BB01
ATC
ipratropium bromide; inhalant
4.7
12.3
29
65
A02BA03
ATC
famotidine; systemic
5.7
12.3
23
42
C10AC01
ATC
colestyramine; oral
5.7
12.3
23
42
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
11.6
12.2
22
20
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
12.2
106
525
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
5.5
12.2
24
46
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
22.1
12.1
17
8
WVA20, ,
SPAT
5.9
12.1
22
39
L50.9
ICD-10 Finland
Urticaria, unspecified
4.0
12.0
35
93
L50.8
ICD-10 Finland
Other urticaria
6.1
11.9
21
36
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
11.8
84
379
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
19.6
11.7
17
9
R01AD05
ATC
budesonide; nasal
3.3
11.6
46
151
M05BA04
ATC
alendronic acid; oral
3.6
11.6
39
115
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
11.5
81
363
R4110
NOMESCO Finland
Physiotherapy
2.2
11.4
137
772
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.7
11.4
38
111
E0000UV, ,
ATC
2.0
11.4
193
1239
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.3
11.4
44
142
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.1
11.4
24
49
R03BA01
ATC
beclometasone; inhalant
2.6
11.3
72
308
JN3AD
NOMESCO Finland
Abdominal CT examination
2.9
11.1
58
223
C07AB07
ATC
bisoprolol; oral
2.0
11.1
180
1135
C08DA01
ATC
verapamil; systemic
4.4
11.0
28
67
ZYC01
NOMESCO Finland
Remote contact by phone
3.3
10.9
43
140
XW000
NOMESCO Finland
Bone marrow biopsy
4.5
10.9
27
63
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
10.9
71
306
L04AA06
ATC
mycophenolic acid; systemic
9.2
10.9
22
25
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.1
10.8
142
826
NFC20
NOMESCO Finland
Secondary implantation of hip prosthesis
13.4
10.7
18
14
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
8.3
10.7
23
29
J05AB11
ATC
valaciclovir; oral
2.4
10.6
81
376
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.3
10.6
28
69
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
10.6
167
1038
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
10.5
10
*
D86.0
ICD-10 Finland
Sarcoidosis of lung
+∞
10.5
10
*
B34.9
ICD-10 Finland
Viral infection, unspecified
4.5
10.5
26
61
J01DA01
ATC
[U] cefalexin
2.0
10.5
264
1930
ZXA05
NOMESCO Finland
Left side
2.2
10.3
110
589
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
24.1
10.3
14
6
B01AB05
ATC
enoxaparin; parenteral
2.1
10.3
132
759
R01AD58
ATC
fluticasone, combinations; nasal
2.1
10.2
122
682
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
5.2
10.2
21
42
GD1AD
NOMESCO Finland
Thorax CT examination
3.8
10.1
32
90
J01FA10
ATC
azithromycin; systemic
2.0
10.1
271
2011
R4120
NOMESCO Finland
Occupational therapy
3.1
10.1
44
153
A02BA02
ATC
ranitidine; systemic
2.3
10.0
84
406
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
3.8
10.0
31
86
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.7
10.0
60
248
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.6
9.9
24
55
R06AX22
ATC
ebastine; oral
2.3
9.9
90
451
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.2
9.8
40
133
ZXD05
NOMESCO Finland
Urgent procedure
2.0
9.8
143
860
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.2
9.8
41
139
J01FA09
ATC
clarithromycin; systemic
2.0
9.8
147
893
J01DC02
ATC
cefuroxime; systemic
3.4
9.7
35
108
P01AB01
ATC
metronidazole; oral, rectal
1.9
9.5
182
1199
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.3
9.5
37
120
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
9.4
9
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
22.3
9.4
13
6
A07EC02
ATC
mesalazine; oral, rectal
3.5
9.4
33
100
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.0
9.3
128
750
WX002
NOMESCO Finland
Sedation and analgesia
2.3
9.3
85
426
M54.4
ICD-10 Finland
Lumbago with sciatica
2.2
9.3
89
455
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
14.1
9.2
15
11
XG474
NOMESCO Finland
Exhalation nntrogen oxide
4.5
9.2
23
54
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.8
9.2
50
196
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.2
9.2
25
63
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
8.6
9.2
19
23
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.6
9.2
58
246
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.0
9.2
42
150
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
11.8
9.1
16
14
C03DA01
ATC
spironolactone; oral
2.7
9.1
52
209
R75
ICPC
Sinusitis acute/chronic
3.4
9.1
34
107
A03FA02
ATC
cisapride; oral, rectal
3.2
9.1
37
123
R51.80
ICD-10 Finland
Headache
2.2
9.0
93
489
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
19.1
9.0
13
7
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.7
8.9
21
47
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.1
8.9
39
136
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
8.8
106
590
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
3.6
8.8
29
84
R06AX26
ATC
fexofenadine; oral
2.9
8.8
44
165
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
2.9
8.7
43
160
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.6
8.7
21
48
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
51.1
8.7
10
*
A06AC01
ATC
ispaghula (psylla seeds); oral
2.0
8.7
109
617
K50.9
ICD-10 Finland
Crohn disease, unspecified
7.2
8.6
20
29
ZX108
NOMESCO Finland
Inhalation
16.7
8.6
13
8
J01DA06
ATC
[U] cefuroxime
2.3
8.6
75
368
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.0
8.6
38
133
S97
ICPC
Chronic ulcer skin
3.4
8.5
31
96
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
28.2
8.5
11
*
R03AC13
ATC
formoterol; inhalant
3.6
8.5
29
86
M25.5
ICD-10 Finland
Pain in joint
1.9
8.5
147
928
SPAT1229
SPAT
Assessment of need for aid
3.3
8.5
33
107
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
8.4
50
205
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
8.4
39
140
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.8
8.4
26
72
N03AX12
ATC
[U] gabapentin; oral
2.2
8.4
77
386
E84.0
ICD-10 Finland
Cystic fibrosis with pulmonary manifestations
+∞
8.4
8
*
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
+∞
8.4
8
*
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
+∞
8.4
8
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.4
8.4
60
270
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
9.7
8.3
16
17
D07AC01
ATC
betamethasone; topical
1.9
8.3
148
942
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
8.3
63
291
Z3229
NOMESCO Finland
Other healthcare associate professional
2.7
8.3
48
195
A02BC05
ATC
esomeprazole; systemic
1.9
8.2
170
1133
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.9
8.2
24
64
G47.3
ICD-10 Finland
Sleep apnoea
2.1
8.2
94
514
M35.7
ICD-10 Finland
Hypermobility syndrome
7.1
8.2
19
28
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.8
8.2
184
1260
M54.3
ICD-10 Finland
Sciatica
3.2
8.1
33
110
S01GX01
ATC
cromoglicic acid; ophthalmic
2.0
8.1
101
569
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
7.5
8.0
18
25
N06AX03
ATC
mianserin; oral
3.6
8.0
26
75
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.6
8.0
26
75
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
6.3
7.9
20
33
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.8
7.9
241
1803
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
11.1
7.8
14
13
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.6
7.8
47
194
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
7.8
95
530
7151E
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, LONKKANIVEL]
45.9
7.7
9
*
H02BX01
ATC
methylprednisolone, combinations; systemic
3.9
7.7
23
62
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.7
7.7
18
40
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
7.6
63
301
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
18.8
7.6
11
6
9294
FHL
Endoprosthesis replacement of the entire hip joint (eg Charnley)
18.8
7.6
11
6
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
12.2
7.6
13
11
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
4.2
7.6
20
49
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
7.6
145
938
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
25.5
7.6
10
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.2
7.6
30
98
R03DC01
ATC
zafirlukast; oral
7.3
7.6
17
24
R01AD12
ATC
fluticasone furoate; nasal
1.8
7.6
147
957
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
7.5
167
1131
A07EA06
ATC
budesonide; oral, local oral
3.6
7.5
25
73
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.5
7.5
18
41
XG466
NOMESCO Finland
Sleep oxymetry
4.5
7.5
18
41
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.0
7.5
87
477
NFC40
NOMESCO Finland
Repair of hip prosthesis by bone transplant to acetabulum
81.5
7.4
8
*
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
81.5
7.4
8
*
J02AC01
ATC
fluconazole; systemic
1.8
7.4
178
1233
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
8.6
7.4
15
18
ZXA00
NOMESCO Finland
Right side
1.9
7.4
108
641
R1250
NOMESCO Finland
Evaluation of functional capability
4.3
7.4
19
46
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
11.1
7.3
13
12
A46
ICD-10 Finland
Erysipelas
2.3
7.3
56
259
D89.89
ICD-10 Finland
Other specified disorders involving the immune mechanism, not elsewhere classified
+∞
7.3
7
*
E84.9
ICD-10 Finland
Cystic fibrosis, unspecified
+∞
7.3
7
*
2776B
ICD-9 Finland
Other and unspecified disorders of metabolism, Other deficiencies of circulating enzymes[OEDEMA ANGIONEUROTICUM HEREDITARIUM (HANE)]
+∞
7.3
7
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
+∞
7.3
7
*
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
+∞
7.3
7
*
J01DB01
ATC
cefalexin; oral
2.1
7.3
341
2878
J22
ICD-10 Finland
Unspecified acute lower respiratory infection
2.8
7.3
36
134
E000001, ,
ATC
2.0
7.3
93
526
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.4
7.3
18
42
ZY010
NOMESCO Finland
Hospital outpatient
2.8
7.2
36
135
4AA12, ,
NOMESCO Finland
20.4
7.2
10
5
XA800
NOMESCO Finland
Neuropsychological investigation
3.0
7.1
32
113
J01AA02
ATC
doxycycline; systemic
1.9
7.1
307
2510
M79.7
ICD-10 Finland
Fibromyalgia
3.4
7.1
25
76
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
10.3
7.1
13
13
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
10.3
7.1
13
13
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
7.1
91
516
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
4.0
7.1
20
52
Z2445
NOMESCO Finland
Psychologist
2.9
7.1
34
125
A01
ICPC
Pain general/multiple sites
2.5
7.0
46
198
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
7.0
52
237
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.5
7.0
45
192
J96.1
ICD-10 Finland
Chronic respiratory failure
7.7
7.0
15
20
WX722
NOMESCO Finland
PEEP
3.5
6.9
24
72
R96
ICPC
Asthma
2.5
6.9
46
200
K50.0
ICD-10 Finland
Crohn disease of small intestine
6.9
6.9
16
24
D02AX
ATC
Other emollients and protectives
3.3
6.8
26
83
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.8
6.8
18
32
A07AA09
ATC
vancomycin; oral
9.5
6.8
13
14
N05CD07
ATC
temazepam; oral
2.5
6.8
44
188
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
6.8
109
664
XCK00
NOMESCO Finland
Perimetry
3.1
6.8
28
94
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
4.0
6.8
19
49
SPF20
NOMESCO Finland
Temporary relining of dentures
17.0
6.8
10
6
R42
ICD-10 Finland
Dizziness and giddiness
2.0
6.8
87
493
NF1AA
NOMESCO Finland
Hip X-ray examination
2.8
6.7
35
134
WX402
NOMESCO Finland
General anaesthesia
1.9
6.7
98
579
R06AX13
ATC
loratadine; oral
2.1
6.7
72
382
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
6.6
6.7
16
25
127
Kela drug reimbursment
Transplant complication
6.6
6.7
16
25
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
8.0
6.7
14
18
N06AA09
ATC
amitriptyline; systemic
2.5
6.7
43
184
N05CF01
ATC
zopiclone; oral
1.8
6.6
127
817
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.9
6.6
31
112
R06AX11
ATC
astemizole; oral
4.3
6.6
17
41
N02AC04
ATC
dextropropoxyphene; oral
3.9
6.6
19
50
M04AA01
ATC
allopurinol; systemic
2.5
6.6
44
191
B01AB04
ATC
dalteparin; parenteral
3.2
6.6
26
85
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
6.6
66
341
R01BA52
ATC
pseudoephedrine, combinations; oral
1.8
6.6
127
819
U07.1
ICD-10 Finland
Emergency use of U07.1 | COVID-19, virus identified
1.9
6.6
97
575
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.6
6.6
39
160
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
6.6
64
327
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.7
6.6
35
136
K07.60
ICD-10 Finland
Snapping jaw
2.7
6.6
35
136
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
5.5
6.5
18
34
R03AK11
ATC
formoterol and fluticasone; inhalant
5.5
6.5
18
34
QX3HE
NOMESCO Finland
Ultrsound examination of lesion close to skin
6.4
6.5
16
26
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.3
6.5
24
75
N06AX11
ATC
mirtazapine; oral
1.8
6.5
140
931
R04
ICPC
Breathing problem other
3.5
6.5
22
65
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
6.5
38
155
R07.0
ICD-10 Finland
Pain in throat
2.6
6.5
38
155
SAA04
NOMESCO Finland
Special examination of mouth
2.7
6.5
35
137
WX892
NOMESCO Finland
Monitored bed care
2.7
6.5
36
143
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.2
6.5
26
86
N05BA01
ATC
diazepam; systemic, rectal
2.2
6.5
61
308
J01XB01
ATC
colistin; inhalant, parenteral
70.9
6.4
7
*
R02
ICPC
Shortness of breath/dyspnoea
2.2
6.4
56
274
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
3.7
6.4
20
56
J01DA08
ATC
[U] cefaclor
2.2
6.4
53
254
JN4BD
NOMESCO Finland
Extensive body CT
2.4
6.4
43
188
3AC01, ,
NOMESCO Finland
11.3
6.3
11
10
TAB00
NOMESCO Finland
Lumbar puncture
2.9
6.3
29
104
R05CB13
ATC
dornase alfa (desoxyribonuclease); inhalant
+∞
6.3
6
*
E84.1
ICD-10 Finland
Cystic fibrosis with intestinal manifestations
+∞
6.3
6
*
D84.14
ICD-10 Finland
C1 esterase inhibitor deficiency (C1-INH deficiency)
+∞
6.3
6
*
304
Kela drug reimbursment
Dornase alfa
+∞
6.3
6
*
D82.4
ICD-10 Finland
Hyperimmunoglobulin E [IgE] syndrome
+∞
6.3
6
*
L04AX03
ATC
methotrexate; systemic
2.4
6.3
46
209
W84
ICD-10 Finland
Unspecified threat to breathing
27.1
6.2
8
*
A40.3
ICD-10 Finland
Sepsis due to Streptococcus pneumoniae
27.1
6.2
8
*
A04AA01
ATC
ondansetron; systemic, rectal
2.5
6.2
38
158
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.6
6.2
20
57
J01CF05
ATC
flucloxacillin; systemic
2.8
6.2
32
122
K50.8
ICD-10 Finland
Other Crohn disease
6.4
6.2
15
24
Z71.8
ICD-10 Finland
Other specified counselling
1.7
6.2
138
925
R53
ICD-10 Finland
Malaise and fatigue
1.8
6.2
106
658
N05CF02
ATC
zolpidem; oral
2.0
6.2
75
416
A01AB10
ATC
natamycin; local oral
3.9
6.2
18
48
ZX112
NOMESCO Finland
Subcutaneous
4.2
6.1
16
39
C07AB02
ATC
metoprolol; systemic
2.0
6.1
71
387
UKC02
NOMESCO Finland
Cystoscopy
2.2
6.1
55
272
J06.80
ICD-10 Finland
Continuously repeating infections of a child
12.8
6.1
10
8
TEA00
NOMESCO Finland
Biopsy of lip
12.8
6.1
10
8
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
12.8
6.1
10
8
L04AA01
ATC
[U] ciclosporin
8.8
6.1
12
14
R4190
NOMESCO Finland
Nutritional therapy
2.9
6.1
29
106
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.9
6.1
80
456
ZXH06, ,
SPAT
3.1
6.1
25
84
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
6.0
96
582
N03AE01
ATC
clonazepam; systemic
2.9
6.0
28
101
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
86
25
43.21
139.49
2.7
2.0
—
—
—
0
0
134
117
16.49
137.25
2.6
1.5
0.20
0.23
g/l
2.57
116
117
187
269
11.90
136.28
8.2
2.4
9.49
9.90
g/l
0.54
180
246
170
220
12.45
133.94
3.9
1.7
1.41
1.31
g/l
0.13
157
203
157
246
9.70
104.25
2.2
1.2
315.76
225.27
u/ml
0.28
151
225
69
31
26.53
96.25
2.5
1.8
0.22
0.19
e9/l
0.27
62
22
69
32
25.70
95.04
2.5
1.7
601.85
684.09
e6/l
0.23
62
22
53
10
60.68
93.94
3.4
1.2
638.23
1119.10
u/ml
—
53
10
53
66
9.07
40.62
4.2
2.5
—
—
—
0
0
36
25
15.68
40.40
1.9
2.6
40.70
43.08
%
0.21
26
12
108
284
4.80
39.11
4.5
3.1
0.23
0.22
g/l
0.57
102
271
202
841
3.75
38.46
3.5
1.5
1.76
2.19
g/l
3.33
168
502
50
64
8.75
37.42
8.0
6.4
316.60
541.80
iu/ml
—
5
10
335
2004
4.59
35.68
18.2
9.5
4.01
3.93
e9/l
0.26
324
1737
128
437
3.80
31.97
3.2
1.8
—
—
—
0
0
105
314
4.15
31.65
2.4
1.6
—
—
—
0
0
105
314
4.15
31.65
2.7
1.7
—
—
—
0
0
47
70
7.45
30.82
2.2
1.5
—
—
—
0
0
81
213
4.49
28.79
2.5
1.5
—
—
—
0
0
104
336
3.80
27.81
3.2
2.1
337.04
374.65
nmol/l
0.98
99
312
45
72
6.89
27.58
2.8
1.6
—
—
—
0
0
29
29
10.68
25.89
6.4
4.2
—
—
—
0
0
34
13
28.35
25.29
2.0
1.7
12.06
12.15
u/l
0.02
34
13
35
49
7.71
24.11
3.0
1.7
—
—
—
0
0
35
49
7.71
24.11
3.0
1.7
—
—
—
0
0
241
1363
2.85
23.84
3.8
2.5
77.14
75.68
nmol/l
0.35
229
1233
28
32
9.32
22.67
2.4
1.6
—
—
—
0
0
28
32
9.32
22.67
2.4
1.6
—
—
—
0
0
213
1153
2.75
22.58
6.1
3.1
—
—
—
0
0
54
125
4.82
22.28
1.5
1.3
0.40
1.67
u/ml
—
11
6
34
51
7.18
22.02
4.4
3.3
4.19
4.40
e9/l
0.20
34
51
164
788
2.80
21.78
4.5
2.3
2.86
3.04
mg/l
0.44
157
684
34
53
6.90
21.25
4.4
3.6
59.06
57.25
%
0.30
34
53
33
51
6.95
20.78
2.1
1.5
—
—
—
0
0
103
392
3.17
20.78
4.0
2.6
19.82
22.39
%
1.25
94
338
238
1406
2.64
20.52
14.4
6.9
1.20
1.22
mmol/l
3.64
227
1291
33
52
6.81
20.41
2.1
1.6
—
—
—
0
0
73
226
3.71
20.40
3.7
2.7
66.09
66.81
g/l
0.26
68
209
32
49
7.00
20.32
1.8
1.3
—
—
—
0
0
345
2482
3.40
19.99
17.2
7.0
79.77
81.42
u/l
0.29
337
2333
29
41
7.53
19.75
2.2
1.4
—
—
—
0
0
262
1645
2.63
19.55
10.4
6.2
10.96
11.99
umol/l
0.46
250
1553
52
131
4.40
19.25
2.2
1.6
—
—
—
0
0
216
1260
2.50
18.51
9.9
4.8
35.74
36.37
g/l
0.91
208
1188
248
1542
2.53
18.49
12.8
7.2
1.21
1.22
mmol/l
1.33
221
1333
182
988
2.51
18.14
5.6
3.1
67.96
123.57
e6/l
0.30
154
742
277
1836
2.55
17.64
9.9
4.7
6.31
6.50
mmol/l
1.08
268
1691
167
896
2.45
16.80
5.3
3.0
0.53
0.37
e6/l
0.17
141
656
26
39
7.05
16.77
2.2
1.5
—
—
—
0
0
34
67
5.44
16.77
1.3
1.4
—
—
—
0
0
34
67
5.44
16.77
1.3
1.4
—
—
—
0
0
85
329
3.00
16.37
14.0
7.0
104.09
104.30
mmol/l
0.12
85
329
336
2501
2.86
15.93
11.1
3.9
12.31
10.30
mm/h
2.06
326
2320
131
647
2.50
15.58
4.8
2.5
3.60
5.80
e6/l
2.76
126
575
26
43
6.39
15.31
1.9
1.5
—
—
—
0
0
34
73
4.99
15.23
1.5
1.4
—
—
—
0
0
89
368
2.81
15.11
4.3
3.5
6.99
7.19
umol/l
0.04
76
321
140
724
2.41
14.97
4.0
3.2
1330.60
1048.90
ng/l
0.44
121
609
23
36
6.71
14.25
2.0
1.5
—
—
—
0
0
25
22
12.02
13.98
2.2
1.5
—
—
—
0
0
238
1574
2.21
13.79
4.6
2.8
103.14
97.31
ug/l
0.24
232
1467
109
525
2.46
13.45
4.0
2.9
1.73
2.55
e6/l
0.87
70
284
22
35
6.58
13.42
1.9
1.3
—
—
—
0
0
52
169
3.38
13.31
2.2
1.4
—
—
—
0
0
42
120
3.78
13.03
3.1
2.0
—
—
—
0
0
136
731
2.28
13.02
2.7
2.1
0.85
1.10
mg/l
0.82
120
552
110
542
2.40
12.85
3.8
2.8
0.99
0.86
e6/l
0.16
71
298
100
473
2.47
12.77
4.6
2.5
111.15
94.75
ug/g
0.23
87
376
22
37
6.22
12.72
2.9
1.7
—
—
—
0
0
27
56
5.09
12.55
1.1
1.2
1.56
1.52
u/ml
—
9
21
38
106
3.85
12.19
2.0
2.4
1.24
1.49
g/l
0.81
28
97
38
106
3.85
12.19
4.3
1.9
—
—
—
0
0
37
103
3.85
11.90
1.4
1.3
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
32
80
4.25
11.89
2.6
5.8
0.30
0.37
u/ml
0.47
21
43
26
56
4.89
11.58
3.3
2.0
16.13
16.84
%
0.35
16
25
34
92
3.94
11.37
5.5
2.3
2.36
0.68
g/l
0.77
27
84
26
57
4.80
11.34
1.1
1.1
—
—
—
0
0
23
28
8.63
10.96
3.0
1.1
1.14
5.39
u/ml
0.56
18
13
26
59
4.64
10.89
1.2
1.2
3.82
3.58
u/ml
0.05
11
26
74
326
2.55
10.87
11.8
5.7
1.92
1.79
mmol/l
0.11
65
255
67
284
2.62
10.64
9.0
8.6
1.81
1.20
mmol/l
0.71
53
224
148
881
2.06
10.55
3.7
2.0
120.99
189.77
u/l
3.06
141
840
22
27
8.54
10.45
2.9
2.0
—
—
—
0
0
165
1033
2.00
10.13
4.6
3.1
2.33
2.35
mmol/l
2.44
152
929
62
260
2.63
10.04
7.4
6.1
1.54
1.40
mmol/l
0.11
47
190
193
1279
1.96
10.02
17.6
9.9
1.13
1.18
inr
0.44
62
393
34
101
3.58
9.96
1.9
1.5
0.72
0.07
iu/ml
0.46
15
16
177
1150
1.95
9.65
2.3
1.9
94.12
97.81
pmol/l
0.49
105
587
101
539
2.16
9.47
3.7
3.4
467.57
469.80
ng/l
0.00
54
377
65
288
2.49
9.38
9.6
8.5
5.15
5.13
kpa
0.05
60
275
65
288
2.49
9.38
9.6
8.5
11.50
12.44
kpa
0.76
60
276
29
83
3.68
8.97
2.6
2.2
158.46
318.40
ug/l
1.07
24
76
19
39
5.06
8.92
1.2
1.2
—
—
—
0
0
30
89
3.56
8.80
1.7
1.2
3.18
0.92
u/ml
—
5
5
152
967
1.91
8.61
3.8
2.4
56.03
61.90
u/l
0.51
146
894
33
107
3.27
8.45
1.3
1.1
—
—
—
0
0
17
21
8.39
8.16
4.2
3.8
25.47
25.05
umol/l
0.05
17
21
25
69
3.79
8.14
1.7
1.8
—
—
—
0
0
29
89
3.43
8.09
1.8
1.2
7.56
31.23
u/ml
—
7
10
163
1078
1.85
8.07
5.4
3.2
20.67
29.67
ng/l
1.19
107
656
115
683
1.95
7.90
1.7
1.5
21.99
20.75
nmol/l
0.36
102
585
41
157
2.79
7.89
2.3
1.6
—
—
—
0
0
225
1653
1.80
7.77
5.7
3.5
0.00
0.00
estimate
-0.00
49
338
224
1648
1.79
7.66
7.6
4.9
0.00
0.00
estimate
0.50
46
320
38
142
2.85
7.65
16.9
4.0
0.66
0.67
%
0.06
38
142
101
583
1.97
7.50
1.8
1.6
41758689.44
13481332.72
pmol/l
0.28
91
497
32
110
3.07
7.45
1.7
1.2
1.68
2.94
u/ml
—
5
18
23
64
3.75
7.41
2.7
2.0
128.76
134.16
g/l
0.45
17
44
16
22
7.52
7.25
2.4
1.5
27.64
16.06
umol/l
0.64
16
22
17
38
4.62
7.24
2.2
2.1
—
—
—
0
0
224
1666
1.76
7.22
5.7
3.5
0.00
0.00
estimate
-0.00
48
312
61
297
2.24
7.07
5.5
3.2
—
—
—
0
0
119
739
1.86
7.04
2.7
2.2
—
—
—
0
0
124
784
1.83
6.91
5.2
2.7
8760.08
5585.48
umol/l
0.20
118
701
26
84
3.24
6.71
1.5
1.3
—
—
—
0
0
25
79
3.30
6.68
1.7
1.6
76.14
102.73
u/ml
—
7
12
19
50
3.94
6.61
1.7
1.5
—
—
—
0
0
38
158
2.55
6.24
6.3
7.4
8.89
9.22
kpa
0.46
38
152
11
11
10.24
6.06
1.6
1.4
—
—
—
0
0
27
95
2.97
6.06
1.5
1.4
323.08
311.87
ug/g
0.07
13
52
15
25
6.18
6.05
3.5
1.9
—
—
—
0
0
15
25
6.18
6.05
3.5
1.9
—
—
—
0
0
15
25
6.18
6.05
3.5
1.9
—
—
—
0
0
82
475
1.91
5.92
1.7
1.6
1400.77
1188.71
nmol/l
1.06
66
357
16
41
4.02
5.77
2.3
3.9
36.20
127.54
u/ml
—
5
11
25
88
2.96
5.62
1.8
1.5
227.06
220.36
u/ml
0.03
16
52
22
72
3.17
5.58
7.3
4.6
21.73
25.75
mg/l
0.44
16
56
22
72
3.17
5.58
7.3
4.6
109.90
143.32
mg/l
0.13
16
56
17
37
4.75
5.55
2.3
1.5
—
—
—
0
0
314
2666
1.75
5.45
5.0
4.0
14.48
14.58
pmol/l
0.28
297
2458
379
3424
2.33
5.39
38.3
12.1
21.20
21.60
mg/l
0.10
328
2591
199
1511
1.61
5.35
3.1
2.5
—
—
—
0
0
17
49
3.58
5.23
2.8
1.6
1.46
1.55
mmol/l
0.15
17
49
25
93
2.80
5.10
1.6
1.5
—
—
—
0
0
19
60
3.27
5.10
1.3
1.1
—
—
—
0
0
18
58
3.20
4.69
1.3
1.3
—
—
—
0
0
14
31
4.64
4.60
2.3
1.5
33.14
32.97
pg
0.06
14
31
128
900
1.61
4.57
4.6
3.2
7.45
7.73
mmol/l
0.29
116
784
373
3389
2.06
4.57
36.2
13.3
139.33
139.69
mmol/l
2.24
368
3292
297
2532
1.62
4.56
4.8
3.5
—
—
—
0
0
46
241
2.02
4.42
3.8
2.6
60.45
70.60
ml/min/173m2
0.94
22
96
17
55
3.18
4.41
1.6
1.4
5533.45
14372.84
e6/l
1.01
11
38
373
3399
2.03
4.37
36.4
13.4
3.89
3.95
mmol/l
3.78
368
3292
7
6
11.84
4.29
7.3
3.0
—
—
—
0
0
15
46
3.35
4.23
1.2
1.1
—
—
—
0
0
9
13
7.05
4.18
1.3
1.5
—
—
—
0
0
14
36
3.99
4.03
1.9
1.1
—
—
—
0
0
9
14
6.54
4.00
1.3
1.5
—
—
—
0
0
10
18
5.66
3.99
2.0
1.3
—
—
—
0
0
118
841
1.56
3.90
2.1
1.7
—
—
—
0
0
9
15
6.11
3.83
1.1
1.1
—
—
—
0
0
9
15
6.11
3.83
2.1
1.3
—
—
—
0
0
50
286
1.85
3.73
1.6
1.3
58.21
171.46
iu/ml
3.82
15
118
12
29
4.23
3.73
2.3
1.2
—
—
—
0
0
165
1276
1.49
3.70
6.1
3.6
—
—
—
0
0
9
16
5.72
3.67
2.1
1.3
—
—
—
0
0
12
30
4.09
3.62
2.3
1.3
—
—
—
0
0
113
814
1.53
3.52
5.6
3.7
28.31
9.98
mg/mmol
1.01
75
509
25
113
2.29
3.49
1.7
1.3
—
—
—
0
0
10
22
4.63
3.45
1.1
1.2
—
—
—
0
0
91
629
1.57
3.40
1.5
1.3
23.59
32.48
iu/ml
0.59
33
200
10
24
4.24
3.21
1.7
1.2
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
8
15
5.42
3.20
1.0
1.1
117.00
129.53
%
—
8
15
52
317
1.73
3.16
1.7
1.8
—
—
—
0
0
116
858
1.49
3.16
1.6
1.6
1.36
1.37
mmol/l
0.10
106
747
77
521
1.59
3.14
2.7
2.6
2.43
2.44
mmol/l
0.14
66
457
335
3030
1.57
3.14
27.3
10.9
86.56
86.76
ml/min/173m2
0.05
299
2454
9
21
4.36
3.01
2.3
1.1
—
—
—
0
0
20
88
2.34
2.98
1.1
1.1
0.81
1.59
u/ml
0.34
15
58
124
939
1.46
2.98
1.5
1.4
0.80
1.55
u/ml
1.05
41
253
7
13
5.46
2.88
1.0
1.1
—
—
—
0
0
9
23
3.98
2.79
1.2
1.1
—
—
—
0
0
98
719
1.48
2.75
6.4
3.7
1.02
1.02
kg/l
—
10
105
7
14
5.07
2.74
3.1
1.9
—
—
—
0
0
7
14
5.07
2.74
3.1
1.9
—
—
—
0
0
7
14
5.07
2.74
3.1
1.9
—
—
—
0
0
10
29
3.51
2.71
2.5
4.8
107.60
102.97
%
—
10
29
6
10
6.07
2.70
1.2
1.1
—
—
—
0
0
11
35
3.20
2.66
1.5
1.2
—
—
—
0
0
11
35
3.20
2.66
1.5
1.2
—
—
—
0
0
21
100
2.16
2.63
1.1
1.2
1.26
5.69
u/ml
1.91
16
64
24
121
2.04
2.61
1.3
1.2
—
—
—
0
0
11
36
3.11
2.58
1.5
1.2
—
—
—
0
0
11
36
3.11
2.58
1.5
1.2
—
—
—
0
0
11
36
3.11
2.58
1.5
1.2
—
—
—
0
0
5
7
7.21
2.55
1.2
1.1
—
—
—
0
0
10
31
3.28
2.53
1.0
1.1
—
—
—
0
0
24
123
2.01
2.51
1.3
1.2
—
—
—
0
0
11
37
3.03
2.50
1.5
1.1
—
—
—
0
0
9
26
3.51
2.49
1.7
1.6
—
—
—
0
0
45
285
1.65
2.41
4.0
4.1
10.43
46.42
ug/l
0.66
35
233
5
8
6.31
2.38
1.0
1.0
—
—
—
0
0
15
65
2.36
2.34
1.9
1.4
—
—
—
0
0
29
163
1.84
2.34
5.8
2.9
0.23
0.13
e6/l
0.36
29
158
113
876
1.40
2.33
7.2
3.8
0.00
0.00
estimate
0.50
47
318
24
127
1.94
2.31
1.4
1.4
12.74
11.53
u/l
0.14
19
91
8
23
3.53
2.28
1.3
1.2
—
—
—
0
0
7
18
3.94
2.26
5.4
1.8
—
—
—
0
0
81
595
1.45
2.24
1.5
1.3
5.25
10.23
u/ml
0.75
31
236
39
243
1.67
2.23
1.6
1.8
—
—
—
0
0
339
3137
1.46
2.22
5.9
4.6
1.83
2.24
mu/l
0.55
327
2915
9
30
3.04
2.16
2.2
2.3
—
—
—
0
0
15
68
2.25
2.13
1.2
1.1
—
—
—
0
0
8
25
3.24
2.10
1.4
1.1
—
—
—
0
0
8
26
3.12
2.02
1.0
1.6
—
—
—
0
0
61
433
1.48
2.01
1.7
1.8
1.43
1.41
%
0.08
55
393
10
39
2.60
1.95
1.6
1.3
—
—
—
0
0
8
27
3.00
1.94
1.4
2.7
12.86
22.59
ug/l
—
8
27
7
23
3.08
1.80
1.6
2.0
—
—
—
0
0
7
23
3.08
1.80
1.6
2.0
—
—
—
0
0
252
2262
1.29
1.77
5.7
3.2
46.88
41.21
u/l
0.82
242
2154
6
18
3.37
1.75
6.2
1.8
—
—
—
0
0
9
36
2.53
1.75
1.0
1.4
—
—
—
0
0
8
30
2.70
1.73
2.0
2.8
1.36
4.20
nmol/l
—
8
30
7
24
2.95
1.73
1.1
1.1
—
—
—
0
0
18
98
1.87
1.64
4.9
1.8
—
—
—
0
0
6
20
3.03
1.58
2.7
3.3
—
—
—
0
0
313
2913
1.31
1.55
6.5
5.0
39.36
38.86
mmol/mol
0.38
302
2750
22
341
0.63
1.34
1.5
1.6
—
—
—
0
0
22
137
1.64
1.32
1.5
1.4
151.71
267.81
miu/ml
1.40
14
73
6
26
2.33
1.19
6.2
2.9
—
—
—
0
0
11
57
1.96
1.18
40.1
4.9
68.55
65.99
%
0.16
11
57
9
162
0.55
1.11
1.2
1.4
—
—
—
0
0
7
33
2.14
1.06
1.4
1.2
—
—
—
0
0
33
240
1.41
1.02
1.2
1.3
—
44.37
—
0
15
31
223
1.42
1.02
1.4
1.3
—
—
—
0
0
20
132
1.54
0.99
2.0
1.8
—
—
—
0
0
17
108
1.60
0.98
6.3
1.9
—
—
—
0
0
32
235
1.39
0.95
1.1
1.0
—
—
—
0
0
392
3835
1.46
0.87
46.6
18.2
39.43
40.18
%
1.94
376
3632
6
33
1.83
0.79
1.2
1.1
—
79.00
—
0
6
294
3075
0.85
0.79
4.1
3.6
1.42
1.25
mmol/l
3.38
271
2870
6
34
1.78
0.76
2.8
1.5
—
—
—
0
0
6
34
1.78
0.76
2.8
1.5
—
—
—
0
0
6
34
1.78
0.76
2.8
1.5
—
—
—
0
0
22
160
1.40
0.72
2.5
1.4
7.46
2.96
mg/l
0.89
17
116
7
43
1.64
0.67
3.1
2.7
102.71
105.79
mmol/l
—
7
43
308
3195
0.86
0.66
4.5
4.0
1.44
1.49
mmol/l
1.33
290
2991
27
342
0.77
0.60
11.3
6.1
—
—
—
0
0
6
35
1.72
0.58
2.8
1.5
—
—
—
0
0
6
35
1.72
0.58
2.8
1.5
—
—
—
0
0
5
86
0.58
0.57
1.6
1.5
—
—
—
0
0
18
134
1.36
0.54
1.6
1.5
—
—
—
0
0
6
40
1.51
0.52
1.0
1.1
—
—
—
0
0
30
367
0.80
0.51
2.5
2.7
0.61
0.73
ug/l
0.25
21
228
11
76
1.46
0.48
1.3
1.2
—
—
—
0
0
18
229
0.78
0.43
1.4
1.5
—
—
—
0
0
5
31
1.62
0.43
4.0
1.7
—
—
—
0
0
44
506
0.85
0.42
3.0
4.1
22.81
21.88
%
0.10
14
221
304
3120
0.90
0.38
4.9
4.0
5.74
5.81
mmol/l
0.52
290
2899
23
188
1.24
0.38
2.9
2.3
1628.17
3121.60
u/l
—
6
68
318
3250
0.91
0.34
5.0
4.4
2.82
2.82
mmol/l
0.00
297
3043
6
46
1.31
0.33
1.5
1.2
—
—
—
0
0
6
46
1.31
0.33
1.2
1.5
5.67
7.07
mmol/l
—
6
38
8
66
1.22
0.27
1.4
1.5
—
—
—
0
0
5
41
1.22
0.22
2.0
3.0
18.24
55.40
u/ml
—
5
41
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
316
3208
0.94
0.20
4.4
4.0
4.71
4.73
mmol/l
0.15
298
3014
9
112
0.80
0.20
2.0
1.6
—
—
—
0
0
10
122
0.82
0.19
1.4
1.4
—
—
—
0
0
10
122
0.82
0.19
1.4
1.4
—
—
—
0
0
10
122
0.82
0.19
1.4
1.4
—
—
—
0
0
10
122
0.82
0.19
1.4
1.4
—
—
—
0
0
60
631
0.94
0.13
4.0
4.6
1.48
2.34
ug/l
0.75
51
567
12
134
0.89
0.09
1.3
1.5
—
—
—
0
0
6
58
1.03
0.08
1.3
1.3
1.55
3.30
ug/l
—
6
51
5
60
0.83
0.08
1.8
1.6
—
—
—
0
0
8
74
1.08
0.07
1.5
1.4
32.15
23.16
u/l
—
8
60
50
485
1.04
0.05
2.2
2.0
—
—
—
0
0
67
657
1.02
0.03
1.6
1.5
—
—
—
0
0
13
135
0.96
0.00
2.4
1.7
—
—
—
0
0
54
536
1.01
0.00
2.4
2.1
—
—
—
0
0
8
80
1.00
0.00
1.4
1.3
—
—
—
0
0
9
99
0.91
0.00
1.6
1.7
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.1
22.00
14.05
u/l
—
5
44
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
2.23
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
65.20
—
0
5
0
8
0.00
-0.00
0.0
2.6
—
27.25
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_IMMUDEFOTHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEFOTHER | 1.966 [1.61, 2.4] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.164 |
During the follow-up period (1.1.1998 — 31.12.2019), 290 out of 1479 females with D3_IMMUDEFOTHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_IMMUDEFOTHER | 2.078 [1.62, 2.67] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 187 out of 855 males with D3_IMMUDEFOTHER died.
Mortality risk
Mortality risk for people of age
years, who have D3_IMMUDEFOTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.147% | 0.391% |
| 5 | 1.014% | 2.209% |
| 10 | 2.58% | 5.648% |
| 15 | 5.512% | 10.441% |
| 20 | 9.694% | 17.119% |
Relationships between endpoints
↥Index endpoint: D3_IMMUDEFOTHER – Other immunodeficiencies
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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