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Defects in the complement system

DOID Endpoint Browser PheWeb

D3_COMPLEMENTDEF

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D84.1
  • Hospital discharge: ICD-9 — 2798B
  • Cause of death: ICD-10 — D84.1
  • Cause of death: ICD-9 — 2798B

2 out of 7 registries used, show all original rules.

258

4. Check minimum number of events

None

258

5. Include endpoints

None

258

6. Filter based on genotype QC (FinnGen only)

244

Control definitions (FinnGen only)

Control exclude
D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D84
Name in latin
Deficientia systematis complementi

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1516 980 531
Only index persons 1328 892 436
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.01
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 36.99 41.26 28.98
Only index persons 40.75 42.47 37.23

-FinnGen-

Key figures

All Female Male
Number of individuals 244 183 61
Unadjusted period prevalence (%) 0.06 0.06 0.03
Median age at first event (years) 45.30 45.25 45.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
258
Matched controls
2580
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
134.5
117
*
T78.3
ICD-10 Finland
Angioneurotic oedema
66.5
115.6
65
13
D84.1
ICD-10 Finland
Defects in the complement system
+∞
81.7
74
*
D84.19
ICD-10 Finland
Unspecified defect in the complement system
+∞
72.4
66
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
14.0
55.5
56
50
H02AB06
ATC
prednisolone; systemic
7.3
47.3
197
795
D84.11
ICD-10 Finland
Hereditary angioedema type I
+∞
40.7
38
*
D84.13
ICD-10 Finland
Hereditary angioedema type III
+∞
37.4
35
*
338
Kela drug reimbursment
C1-esterase inhibitor, icatibant and conestat alfa
+∞
36.3
34
*
ZX120
NOMESCO Finland
Intravenous
6.8
35.9
67
127
R03DC03
ATC
montelukast; oral
5.3
35.8
101
280
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.9
34.7
167
701
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.8
34.3
124
417
C01CA24
ATC
epinephrine; parenteral
6.7
34.3
64
121
B06AC02
ATC
icatibant; parenteral
+∞
34.1
32
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
12.1
31.1
33
31
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
29.8
28
*
R60.9
ICD-10 Finland
Oedema, unspecified
9.4
29.0
37
45
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.1
27.4
33
37
H02AB07
ATC
prednisone; oral
5.2
27.2
67
162
B02AA02
ATC
tranexamic acid; systemic
4.5
27.1
90
277
H02AB09
ATC
hydrocortisone; systemic
9.8
26.9
33
38
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
26.5
25
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.7
26.2
75
205
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
25.4
24
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
24.4
23
*
R03BB04
ATC
tiotropium bromide; inhalant
6.2
22.5
42
78
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
22.2
21
*
XQ800
NOMESCO Finland
Prick test
4.9
21.5
54
131
H02AB04
ATC
methylprednisolone; systemic
4.4
21.5
66
188
J45.9
ICD-10 Finland
Asthma, unspecified
3.8
21.4
89
315
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
5.3
21.3
48
106
J01MA14
ATC
moxifloxacin; systemic
5.4
21.3
47
102
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.9
21.3
31
44
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.7
20.8
89
320
WW200
NOMESCO Finland
Immunization
18.1
20.7
32
20
R50.9
ICD-10 Finland
Fever, unspecified
3.9
20.3
77
255
UJF32
NOMESCO Finland
Coloscopy
3.6
20.1
92
345
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.5
19.5
55
146
X59
ICD-10 Finland
Exposure to unspecified factor
3.6
19.3
84
304
UGC12
NOMESCO Finland
Flexible bronchoscopy
6.6
19.2
33
56
TPH04
NOMESCO Finland
Cathetrisation of vein
3.5
19.1
88
330
R60.0
ICD-10 Finland
Localized oedema
4.7
18.9
50
126
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.6
18.0
37
75
J01MA12
ATC
levofloxacin; systemic
3.8
17.7
67
220
P01BA02
ATC
hydroxychloroquine; oral
4.9
17.5
43
102
WZC30
NOMESCO Finland
Teaching
3.6
17.3
70
240
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
16.9
16
*
R06.0
ICD-10 Finland
Dyspnoea
3.2
16.7
92
381
T78.4
ICD-10 Finland
Allergy, unspecified
5.7
16.5
33
65
R06AE07
ATC
cetirizine; oral
3.0
16.3
156
875
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.9
16.3
135
701
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.4
16.2
75
279
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.7
16.0
61
200
J31.0
ICD-10 Finland
Chronic rhinitis
4.3
16.0
47
128
R06AE09
ATC
levocetirizine; oral
3.4
15.9
70
252
B06AC05
ATC
lanadelumab; parenteral
+∞
15.8
15
*
D84.12
ICD-10 Finland
Hereditary angioedema type II
+∞
15.8
15
*
J01MA02
ATC
ciprofloxacin; systemic
2.9
15.5
114
551
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.0
15.1
28
51
J45.1
ICD-10 Finland
Nonallergic asthma
4.3
15.1
44
119
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
14.7
14
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.1
14.7
46
131
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
14.6
84
353
UJF30
NOMESCO Finland
Ileoscopy through colon
4.2
14.6
43
117
J01FF01
ATC
clindamycin; systemic
2.9
14.5
92
409
A02BC01
ATC
omeprazole; systemic
2.9
14.0
89
395
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.4
13.8
38
98
R06AX27
ATC
desloratadine; oral
2.7
13.5
118
614
J47
ICD-10 Finland
Bronchiectasis
22.7
13.5
19
9
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
11.9
13.3
24
22
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.8
13.3
32
74
Z31.5
ICD-10 Finland
Genetic counselling
4.0
13.2
41
116
C08DA01
ATC
verapamil; systemic
6.4
12.8
22
37
ZYC01
NOMESCO Finland
Remote contact by phone
4.2
12.6
37
100
R03AC02
ATC
salbutamol; inhalant
2.8
12.6
183
1208
B06AC01
ATC
c1-inhibitor, plasma derived; parenteral
+∞
12.6
12
*
R03AK08
ATC
formoterol and beclometasone; inhalant
5.5
12.5
25
49
UJF92
NOMESCO Finland
Capsular endoscopy
11.9
12.3
22
20
N03AX16
ATC
[U] pregabalin
2.8
11.9
76
334
N06AX21
ATC
duloxetine; oral
3.3
11.8
52
185
R03AK07
ATC
formoterol and budesonide; inhalant
2.8
11.8
76
336
SPAT1255
SPAT
Intravenous administration of medicine
5.2
11.7
25
52
C03CA01
ATC
furosemide; systemic
2.9
11.6
66
272
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.9
11.5
65
267
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
5.5
11.5
23
45
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.8
11.5
38
112
J45.8
ICD-10 Finland
Mixed asthma
8.7
11.4
24
30
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
11.2
95
479
A01AB09
ATC
miconazole; local oral
4.0
11.1
34
95
J01FA06
ATC
roxithromycin; oral
2.4
11.0
120
678
B34.9
ICD-10 Finland
Viral infection, unspecified
5.5
11.0
22
43
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
10.9
91
454
R01AD08
ATC
fluticasone; nasal
2.5
10.9
103
545
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.5
10.9
28
68
N02AX02
ATC
tramadol; systemic, rectal
2.4
10.9
117
657
M79.7
ICD-10 Finland
Fibromyalgia
5.2
10.7
23
48
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.7
10.6
68
298
E0000UV, ,
ATC
2.4
10.5
131
782
L50.9
ICD-10 Finland
Urticaria, unspecified
4.5
10.4
27
66
A06AD11
ATC
lactulose; oral
3.4
10.3
40
131
R03BA08
ATC
ciclesonide; inhalant
3.4
10.0
39
128
L04AX01
ATC
azathioprine; systemic
5.0
10.0
22
47
R03AC12
ATC
salmeterol; inhalant
5.0
10.0
22
47
A02BC02
ATC
pantoprazole; systemic
2.4
9.9
174
1194
G47.3
ICD-10 Finland
Sleep apnoea
2.6
9.8
69
315
ZXA10
NOMESCO Finland
Bilateral
2.7
9.7
64
283
J45
ICD-10 Finland
Asthma
3.2
9.7
42
147
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.3
9.6
169
1154
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.4
9.6
90
471
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.2
9.5
20
41
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
10.1
9.4
18
19
R03DA04
ATC
theophylline; systemic, rectal
7.8
9.4
21
29
N05BA01
ATC
diazepam; systemic, rectal
3.0
9.4
46
173
R01AD05
ATC
budesonide; nasal
3.7
9.4
32
96
L01BA01
ATC
methotrexate; systemic
8.2
9.3
20
26
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
9.3
39
134
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.5
9.1
69
326
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
9.1
108
622
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
3.7
9.1
31
93
6BA02, ,
NOMESCO Finland
38.1
9.1
11
*
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
38.1
9.1
11
*
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.2
8.9
25
65
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
3.0
8.9
43
161
R51.80
ICD-10 Finland
Headache
2.5
8.9
67
316
R03BA02
ATC
budesonide; inhalant
2.5
8.8
69
330
J05AB11
ATC
valaciclovir; oral
2.7
8.8
56
242
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.9
8.8
27
75
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.3
8.7
35
117
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.5
8.5
31
97
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.9
8.5
26
72
C08CA13
ATC
lercanidipine; oral
3.0
8.3
39
143
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.8
8.3
45
179
R01AD09
ATC
mometasone; nasal
2.1
8.3
144
956
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
8.2
49
205
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.9
8.2
41
156
Z3226
NOMESCO Finland
Physiotherapist
2.4
8.2
66
320
A07AA02
ATC
nystatin; oral
4.0
8.1
24
65
M54.4
ICD-10 Finland
Lumbago with sciatica
2.5
8.1
61
286
R06AX26
ATC
fexofenadine; oral
3.3
8.1
32
106
J01FA10
ATC
azithromycin; systemic
2.2
8.0
181
1321
L04AB04
ATC
adalimumab; parenteral
8.2
8.0
17
22
Z3231
NOMESCO Finland
Registered nurse
2.2
8.0
95
542
R03BA05
ATC
fluticasone; inhalant
2.3
8.0
72
366
R07.0
ICD-10 Finland
Pain in throat
3.4
8.0
30
96
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
13.6
8.0
13
10
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.0
7.9
37
135
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.0
7.9
37
135
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
3.5
7.9
29
91
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.7
7.9
26
76
R04
ICPC
Breathing problem other
4.8
7.8
18
40
4AA12, ,
NOMESCO Finland
46.4
7.8
9
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.7
7.8
25
72
R01AD58
ATC
fluticasone, combinations; nasal
2.2
7.7
82
446
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
19.1
7.7
11
6
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
7.5
31
105
R53
ICD-10 Finland
Malaise and fatigue
2.3
7.5
74
390
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.0
7.5
36
134
J32.4
ICD-10 Finland
Chronic pansinusitis
13.9
7.5
12
9
C03DA01
ATC
spironolactone; oral
3.1
7.4
33
117
N02AA05
ATC
oxycodone; systemic
2.7
7.4
44
183
2776B
ICD-9 Finland
Other and unspecified disorders of metabolism, Other deficiencies of circulating enzymes[OEDEMA ANGIONEUROTICUM HEREDITARIUM (HANE)]
+∞
7.3
7
*
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
7.3
7
*
L04AX03
ATC
methotrexate; systemic
3.0
7.3
34
124
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
7.2
33
119
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.0
7.2
33
119
WX892
NOMESCO Finland
Monitored bed care
3.5
7.2
25
76
N03AX12
ATC
[U] gabapentin; oral
2.5
7.2
52
239
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
12.5
7.2
12
10
M35.7
ICD-10 Finland
Hypermobility syndrome
9.2
7.1
14
16
ZYC05
NOMESCO Finland
Non-real-time text-based remote communication
9.2
7.1
14
16
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.1
7.1
20
52
M25.5
ICD-10 Finland
Pain in joint
2.1
7.1
99
595
ZY010
NOMESCO Finland
Hospital outpatient
3.2
7.1
30
103
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.2
7.1
30
103
X57
ICD-10 Finland
Unspecified privation
7.3
7.1
16
23
XG410
NOMESCO Finland
Flow-volume spirometry
4.6
7.1
17
39
WZC00
NOMESCO Finland
Treatment plan or consultation
2.0
7.0
108
673
ZXH06, ,
SPAT
3.9
6.9
21
58
M54.3
ICD-10 Finland
Sciatica
3.7
6.9
22
63
A03FA02
ATC
cisapride; oral, rectal
3.6
6.9
23
68
R42
ICD-10 Finland
Dizziness and giddiness
2.3
6.9
58
285
R01BA51
ATC
phenylpropanolamine, combinations; oral
2.7
6.8
40
165
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
6.8
70
373
S01GX01
ATC
cromoglicic acid; ophthalmic
2.2
6.8
73
396
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
17.3
6.8
10
6
Z2446
NOMESCO Finland
Social worker
2.8
6.8
35
135
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
41.2
6.8
8
*
A01
ICPC
Pain general/multiple sites
3.0
6.8
31
112
R75
ICPC
Sinusitis acute/chronic
3.6
6.7
23
69
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
6.7
85
492
A02BC05
ATC
esomeprazole; systemic
2.0
6.7
105
657
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.1
6.7
77
430
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
4.4
6.7
17
41
N06AX03
ATC
mianserin; oral
4.4
6.7
17
41
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.9
6.6
32
119
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
3.9
6.6
20
55
SPAT1229
SPAT
Assessment of need for aid
3.9
6.6
20
55
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
6.6
35
137
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
5.6
6.6
18
34
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
5.6
6.6
18
34
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.7
6.6
21
60
C07AB07
ATC
bisoprolol; oral
2.0
6.6
105
660
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
6.5
107
680
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
6.9
6.4
15
23
L50.8
ICD-10 Finland
Other urticaria
6.9
6.4
15
23
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
6.9
6.4
15
23
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
6.2
6.4
16
27
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
6.3
61
317
D84.14
ICD-10 Finland
C1 esterase inhibitor deficiency (C1-INH deficiency)
+∞
6.3
6
*
D84.8
ICD-10 Finland
Other specified immunodeficiencies
+∞
6.3
6
*
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
6.3
6
*
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
27.4
6.3
8
*
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
27.4
6.3
8
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.7
6.3
35
141
R02
ICPC
Shortness of breath/dyspnoea
2.6
6.2
37
154
Z2221
NOMESCO Finland
Medical doctor
2.0
6.2
87
520
B01AB05
ATC
enoxaparin; parenteral
2.1
6.2
78
449
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.8
6.2
33
130
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.5
6.1
21
63
L04AB01
ATC
etanercept; parenteral
12.9
6.1
10
8
TGC00
NOMESCO Finland
Bronchial lavation
8.9
6.1
12
14
A02BC03
ATC
lansoprazole; oral
2.1
6.1
75
427
H02BX01
ATC
methylprednisolone, combinations; systemic
5.8
6.1
16
29
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.1
6.1
26
90
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
7.5
6.0
13
18

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
106
80
21.79
120.11
2.4
1.4
0.19
0.24
g/l
3.66
89
80
58
21
35.34
88.02
2.7
1.2
—
—
—
0
0
113
168
11.19
79.85
7.1
2.2
9.37
9.96
g/l
0.66
108
158
104
139
11.86
79.75
3.4
1.7
1.57
1.33
g/l
0.24
97
132
206
1036
5.90
33.44
15.1
6.8
—
—
—
0
0
209
1107
5.68
30.57
14.7
6.4
0.56
0.54
e9/l
0.76
203
961
209
1108
5.67
30.50
14.7
6.4
0.04
0.04
e9/l
0.47
203
958
210
1140
5.53
29.11
15.1
6.8
0.19
0.19
e9/l
0.14
205
1006
209
1133
5.45
28.95
14.8
6.4
2.14
2.08
e9/l
0.20
204
1011
96
302
4.47
28.17
1.9
1.4
456.00
540.29
titre
0.27
20
69
23
0
+∞
24.35
1.7
0.0
—
—
—
0
0
130
565
3.62
23.12
2.9
1.4
1.71
2.07
g/l
2.20
107
333
73
215
4.34
22.89
3.4
2.1
321.07
359.35
nmol/l
0.75
68
201
209
1283
4.31
20.80
16.8
9.5
3.98
3.86
e9/l
0.37
204
1108
181
1014
3.63
20.69
17.3
8.9
0.00
0.00
e9/l
0.51
158
815
27
34
8.75
20.41
4.5
2.7
4.15
4.80
e9/l
0.58
27
34
27
34
8.75
20.41
4.4
3.2
58.59
59.29
%
0.09
27
34
24
7
37.58
19.26
2.9
1.3
767.79
1447.71
u/ml
—
24
7
104
432
3.36
19.19
7.0
3.8
—
—
—
0
0
121
578
3.06
17.22
10.7
7.6
—
—
—
0
0
151
861
2.82
14.82
15.3
7.6
1.20
1.22
mmol/l
1.95
142
793
152
877
2.78
14.46
3.5
2.5
77.01
74.26
nmol/l
0.57
144
791
23
17
14.72
14.02
5.6
2.5
—
—
—
0
0
101
482
2.80
13.79
5.2
2.4
2.90
2.95
mg/l
0.09
96
420
48
151
3.68
13.26
5.0
5.1
0.50
0.55
%
0.06
18
49
47
148
3.66
12.95
5.2
5.6
0.00
0.00
%
-0.00
17
45
38
103
4.15
12.92
4.2
2.2
—
—
—
0
0
50
165
3.52
12.84
5.1
5.4
0.86
0.77
%
0.11
21
63
60
223
3.20
12.74
3.4
1.6
—
—
—
0
0
155
951
2.58
12.30
11.3
7.5
1.21
1.22
mmol/l
0.53
134
827
104
532
2.60
12.07
6.9
4.1
7.41
7.40
ph
0.36
23
92
69
290
2.88
11.73
6.4
4.8
0.80
0.82
mmol/l
1.01
69
277
84
392
2.69
11.69
4.4
2.7
510.49
545.96
mosm/kgh2o
0.79
79
335
46
153
3.44
11.62
5.4
5.7
0.00
0.10
%
1.24
17
51
214
1567
3.14
11.49
15.0
6.7
78.16
81.70
u/l
0.61
208
1464
174
1150
2.58
11.45
10.7
4.8
6.25
6.41
mmol/l
0.57
167
1059
65
273
2.85
11.01
3.2
2.0
—
—
—
0
0
160
1035
2.44
10.76
7.8
6.1
11.48
12.23
umol/l
0.18
150
976
215
1603
3.05
10.68
11.1
3.9
11.90
9.92
mm/h
1.51
209
1491
132
787
2.39
10.66
8.4
5.0
36.40
36.66
g/l
0.22
126
743
10
0
+∞
10.48
2.1
0.0
—
—
—
0
0
42
141
3.36
10.42
1.7
1.4
—
—
—
0
0
102
547
2.43
10.41
3.4
2.0
123.98
157.08
u/l
0.79
97
525
66
292
2.69
10.04
3.9
2.6
11.72
14.21
umol/l
2.56
66
272
101
557
2.34
9.51
5.3
3.0
—
—
—
0
0
108
618
2.29
9.28
5.3
3.2
96.39
59.17
e6/l
0.20
96
451
29
82
3.86
9.25
1.2
1.2
—
—
—
0
0
122
737
2.24
9.16
6.0
3.8
130.78
41.00
e6/l
0.40
101
479
20
27
7.93
9.12
1.5
1.7
—
—
—
0
0
50
207
2.76
8.56
2.2
1.4
—
—
—
0
0
99
563
2.23
8.48
5.5
3.1
0.72
0.32
e6/l
0.29
87
398
25
68
3.96
8.40
21.5
6.4
—
—
—
0
0
18
38
5.02
8.25
1.2
1.3
3.25
4.05
u/ml
—
8
19
21
51
4.39
8.16
2.5
2.6
—
—
—
0
0
67
332
2.38
7.87
4.9
2.6
135.39
86.68
ug/g
0.58
57
262
47
197
2.69
7.83
16.8
9.7
—
—
—
0
0
38
143
2.94
7.73
2.9
3.2
82.26
72.72
e9/l
0.72
25
108
50
219
2.59
7.63
1.5
1.3
—
—
—
0
0
84
469
2.17
7.37
3.2
2.3
0.93
1.09
mg/l
0.29
74
352
129
847
2.05
7.34
5.4
3.2
5.94
5.97
ph
—
9
87
18
31
6.16
7.06
2.7
2.4
17.08
16.93
%
—
10
15
50
230
2.46
6.85
14.5
6.4
1.54
1.60
mmol/l
0.04
45
179
119
774
2.00
6.81
14.8
9.3
1.09
1.16
inr
0.60
43
244
48
218
2.48
6.76
19.8
6.7
103.23
104.28
mmol/l
0.51
48
218
18
33
5.78
6.75
2.8
2.6
—
—
—
0
0
50
233
2.42
6.66
4.1
4.1
4.49
7.44
umol/l
1.17
41
206
41
174
2.61
6.63
5.4
6.9
7.42
7.42
ph
—
7
10
29
102
3.08
6.61
21.0
4.6
0.69
0.65
%
0.27
29
102
41
175
2.60
6.56
5.4
6.9
5.16
5.09
kpa
0.20
41
165
22
67
3.50
6.29
17.1
5.5
—
—
—
0
0
29
105
2.99
6.29
21.0
4.6
1.56
1.22
%
0.71
29
105
42
187
2.49
6.15
9.9
11.2
24.40
24.72
mmol/l
0.31
42
187
17
33
5.44
6.13
1.3
1.2
—
—
—
0
0
55
277
2.25
6.11
1.7
1.6
1504.25
1177.86
nmol/l
1.42
44
214
185
1439
2.01
5.94
7.4
4.1
—
—
—
0
0
33
134
2.68
5.81
1.3
1.2
—
—
—
0
0
101
648
1.92
5.80
5.5
3.2
16.26
26.02
ng/l
1.32
66
360
22
71
3.29
5.77
1.5
1.7
—
—
—
0
0
107
702
1.90
5.73
2.2
1.8
99.29
96.73
pmol/l
0.22
62
348
40
181
2.43
5.65
1.7
1.3
49.94
156.96
iu/ml
2.75
12
78
60
329
2.07
5.34
2.0
1.6
70370819.39
23843873.67
pmol/l
0.27
54
281
100
655
1.86
5.29
3.3
3.1
2.33
2.36
mmol/l
2.45
91
599
48
243
2.20
5.23
3.3
1.4
—
—
—
0
0
16
36
4.67
5.15
3.6
2.7
9.58
9.07
kpa
0.44
16
36
16
36
4.67
5.15
3.6
2.7
4.78
4.97
kpa
0.47
16
36
60
336
2.02
5.02
3.5
3.1
2.12
3.01
e6/l
0.54
40
181
38
180
2.30
4.84
10.0
7.8
1.81
1.45
mmol/l
0.24
33
136
13
25
5.42
4.84
5.2
6.6
—
—
—
0
0
141
1047
1.76
4.77
7.7
4.7
0.00
0.00
estimate
0.50
33
201
141
1047
1.76
4.77
6.1
3.3
0.00
0.00
estimate
-0.00
33
213
22
80
2.91
4.75
1.5
1.1
—
—
—
0
0
18
58
3.26
4.74
1.3
1.7
—
—
—
0
0
32
142
2.43
4.71
6.1
3.5
—
—
—
0
0
68
407
1.91
4.68
1.7
1.4
23.02
20.93
nmol/l
0.49
58
348
7
5
14.33
4.60
2.1
2.2
140.14
128.40
nmol/l
—
7
5
67
402
1.90
4.56
1.6
1.3
23.90
26.36
iu/ml
0.11
26
129
141
1057
1.74
4.53
6.1
3.3
0.00
0.00
estimate
-0.00
33
192
47
252
2.06
4.40
1.3
1.2
—
—
—
0
0
10
16
6.45
4.33
1.1
1.2
0.07
0.13
u/ml
—
5
6
7
6
11.94
4.30
7.3
2.0
10.02
12.65
mg/l
—
7
6
75
475
1.82
4.29
6.0
3.3
—
—
—
0
0
27
116
2.48
4.25
5.0
8.0
9.28
9.60
kpa
0.34
27
110
34
163
2.25
4.21
13.0
10.2
10.28
7.04
mmol/l
1.26
34
156
13
30
4.51
4.19
2.2
1.8
1.61
1.48
mmol/l
0.18
13
30
74
471
1.80
4.15
2.1
2.0
—
—
—
0
0
8
10
8.21
4.09
2.1
3.4
—
—
—
0
0
57
336
1.89
4.07
3.6
3.3
75.37
384.95
ng/l
2.35
27
228
9
14
6.62
4.02
2.1
2.9
—
—
—
0
0
13
32
4.22
3.96
3.9
2.6
—
—
—
0
0
23
95
2.56
3.93
10.9
4.7
—
—
—
0
0
91
626
1.70
3.85
2.7
2.3
—
—
—
0
0
9
15
6.17
3.85
2.8
1.7
—
—
—
0
0
9
15
6.17
3.85
1.1
1.3
—
—
—
0
0
7
8
8.95
3.79
1.7
1.6
11.10
9.63
umol/l
—
7
8
6
5
12.24
3.78
1.0
1.0
—
—
—
0
0
8
12
6.84
3.70
3.7
5.1
24.50
26.92
umol/l
—
8
12
9
16
5.78
3.69
2.9
1.2
29.62
17.31
umol/l
—
9
16
81
546
1.70
3.66
7.3
3.4
0.00
0.00
estimate
0.50
33
201
12
30
4.14
3.64
3.6
2.7
—
—
—
0
0
33
168
2.11
3.53
7.0
3.3
—
—
—
0
0
10
22
4.68
3.46
1.1
1.2
0.51
0.41
u/ml
—
5
11
241
2196
2.48
3.42
35.8
11.4
20.23
21.45
mg/l
0.26
206
1635
13
42
3.21
3.42
1.3
1.1
—
—
—
0
0
89
625
1.65
3.41
1.5
1.4
0.47
1.51
u/ml
2.23
29
174
9
18
5.14
3.40
1.0
1.2
—
—
—
0
0
24
109
2.33
3.37
1.7
1.4
—
—
—
0
0
54
334
1.78
3.27
1.7
1.6
—
—
—
0
0
200
1722
1.72
3.27
5.2
4.0
14.41
14.49
pmol/l
0.17
188
1592
10
24
4.29
3.23
1.4
1.6
—
—
—
0
0
11
29
3.91
3.22
1.5
1.2
—
—
nmol/l
—
0
0
16
61
2.73
3.20
1.7
1.3
336.86
299.56
ug/g
—
7
31
83
584
1.62
3.12
4.0
2.6
—
—
—
0
0
6
8
7.64
3.07
2.2
1.9
—
—
—
0
0
84
596
1.61
3.04
4.5
3.0
—
—
—
0
0
5
5
10.16
2.99
2.0
1.6
1.26
1.25
umol/l
—
5
5
11
32
3.54
2.93
1.6
1.2
—
—
—
0
0
15
59
2.64
2.84
1.9
1.6
174.90
241.66
u/ml
—
10
35
31
168
1.96
2.82
1.4
1.4
—
—
—
0
0
8
18
4.55
2.82
1.6
1.3
—
—
—
0
0
12
39
3.18
2.81
2.4
1.6
—
—
—
0
0
5
6
8.46
2.76
1.0
1.0
—
—
—
0
0
5
6
8.46
2.76
1.0
1.0
—
—
—
0
0
5
6
8.46
2.76
1.0
1.0
—
—
—
0
0
5
6
8.46
2.76
1.4
2.7
200.20
168.83
ug/g
—
5
6
15
60
2.59
2.75
1.7
1.4
—
—
—
0
0
6
10
6.11
2.71
1.0
1.5
—
—
—
0
0
16
67
2.48
2.69
1.2
1.1
5.77
5.91
u/ml
—
10
42
59
395
1.64
2.67
1.4
1.3
7.00
10.02
u/ml
0.29
22
163
50
322
1.69
2.62
1.9
2.5
2.44
2.44
mmol/l
0.02
43
283
11
36
3.15
2.60
1.3
1.2
—
—
—
0
0
10
31
3.31
2.54
1.0
1.1
—
—
—
0
0
14
57
2.54
2.49
1.3
1.2
—
—
—
0
0
14
57
2.54
2.49
1.3
1.2
—
—
—
0
0
107
834
1.48
2.44
2.3
2.0
—
—
—
0
0
10
33
3.11
2.38
1.0
1.1
—
—
—
0
0
5
8
6.35
2.38
1.4
1.0
—
—
—
0
0
15
65
2.39
2.36
1.1
1.1
0.26
0.78
u/ml
—
10
45
79
583
1.51
2.33
4.9
3.2
7.90
7.75
mmol/l
0.10
72
511
18
87
2.15
2.23
1.2
1.5
10.43
10.80
u/l
0.04
13
61
5
9
5.64
2.22
1.0
1.1
—
—
—
0
0
20
102
2.04
2.17
21.6
7.0
25.72
24.87
mmol/l
0.38
20
95
9
30
3.07
2.17
1.4
1.2
—
—
—
0
0
6
14
4.36
2.16
4.3
4.3
—
—
—
0
0
63
453
1.52
2.08
6.9
3.4
1.01
1.02
kg/l
—
6
67
5
10
5.07
2.08
2.4
2.1
4.44
4.88
mg/l
—
5
10
8
26
3.14
2.03
1.6
1.2
—
—
—
0
0
7
21
3.40
1.98
1.0
1.0
—
—
—
0
0
67
494
1.48
1.96
3.5
3.3
—
—
—
0
0
5
11
4.61
1.95
1.4
1.3
—
—
—
0
0
6
16
3.81
1.94
1.2
1.3
—
—
—
0
0
25
144
1.82
1.93
7.5
7.6
—
—
—
0
0
6
17
3.59
1.85
1.2
1.4
—
—
—
0
0
65
482
1.47
1.84
4.9
3.1
2140.60
199.02
mg/l
0.71
43
312
6
18
3.39
1.75
1.7
1.1
—
—
—
0
0
67
506
1.44
1.72
5.7
3.7
8.62
10.45
mg/mmol
0.15
42
309
39
268
1.54
1.59
1.3
1.2
—
—
—
0
0
27
170
1.66
1.56
1.3
1.2
—
15.00
—
0
5
16
86
1.92
1.54
1.3
1.1
—
—
—
0
0
72
564
1.38
1.49
1.5
1.7
1.36
1.38
mmol/l
0.08
64
497
5
16
3.16
1.44
1.0
1.3
—
—
—
0
0
5
16
3.16
1.44
1.0
1.1
—
—
—
0
0
217
2024
1.45
1.39
5.9
4.7
1.73
2.44
mu/l
0.65
211
1886
163
1454
1.33
1.39
5.9
3.2
43.87
39.21
u/l
0.46
156
1387
9
41
2.24
1.38
1.8
1.3
—
—
—
0
0
6
23
2.65
1.37
1.0
1.5
668.17
443.96
pmol/l
—
6
23
5
18
2.81
1.29
1.8
1.4
33.20
32.78
pg
—
5
18
8
37
2.20
1.22
1.0
1.1
—
—
—
0
0
5
19
2.66
1.22
1.4
1.5
—
—
—
0
0
181
1951
0.76
1.20
4.0
3.6
1.40
1.27
mmol/l
1.93
171
1827
14
80
1.79
1.15
12.4
11.7
—
—
—
0
0
184
1974
0.76
1.13
4.6
3.9
5.73
5.78
mmol/l
0.28
177
1840
10
51
2.00
1.12
1.0
1.1
—
—
—
0
0
7
34
2.09
1.03
2.6
1.3
—
—
—
0
0
37
276
1.40
1.03
2.2
1.6
—
—
—
0
0
9
48
1.91
1.01
1.3
1.1
—
—
—
0
0
239
2300
1.53
0.99
22.9
10.4
—
—
—
0
0
5
23
2.20
0.98
2.6
2.5
1.12
3.70
nmol/l
—
5
23
6
28
2.17
0.92
1.0
1.3
—
—
—
0
0
18
263
0.66
0.91
1.6
1.3
—
—
—
0
0
20
136
1.51
0.89
1.4
1.2
—
—
—
0
0
22
153
1.48
0.89
4.9
4.4
—
—
—
0
0
48
385
1.30
0.86
2.0
1.7
—
—
—
0
0
13
81
1.64
0.83
2.5
2.0
—
—
—
0
0
10
163
0.60
0.81
1.4
1.4
—
—
—
0
0
16
106
1.54
0.81
2.3
2.8
0.22
0.08
e6/l
0.76
16
101
12
186
0.63
0.80
2.3
2.6
0.38
0.70
ug/l
—
7
115
0
25
0.00
0.79
0.0
15.4
—
923.84
—
0
25
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
18.2
—
1684.76
—
0
25
25
184
1.40
0.77
3.1
3.6
17.51
7.90
ug/l
0.27
18
146
10
59
1.72
0.77
1.2
1.7
—
—
—
0
0
5
26
1.94
0.71
1.6
2.5
—
—
—
0
0
5
26
1.94
0.71
1.6
2.5
103.40
105.85
mmol/l
—
5
26
5
26
1.94
0.71
1.6
2.5
4.00
3.97
mmol/l
—
5
26
148
1367
1.19
0.70
4.5
3.2
—
—
—
0
0
5
28
1.80
0.66
1.4
1.2
—
—
—
0
0
197
2055
0.83
0.61
4.9
4.4
2.89
2.85
mmol/l
0.27
189
1931
8
51
1.59
0.61
3.6
4.2
—
—
—
0
0
22
166
1.36
0.61
1.7
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
9.9
—
0.66
—
0
20
194
2024
0.83
0.59
4.3
4.0
1.47
1.49
mmol/l
0.43
186
1900
6
36
1.68
0.57
1.3
1.9
—
—
—
0
0
16
117
1.39
0.53
3.6
2.4
423.00
4563.60
u/l
—
5
40
7
47
1.50
0.48
1.4
1.4
29.74
21.87
u/l
—
7
38
28
229
1.25
0.46
1.0
1.2
—
—
—
0
0
9
129
0.69
0.44
3.6
2.2
—
—
—
0
0
0
16
0.00
0.41
0.0
5.3
—
2.39
—
0
16
20
160
1.27
0.40
1.3
1.2
—
30.68
—
0
8
250
2469
1.40
0.38
42.9
17.4
133.50
134.83
g/l
0.90
250
2438
250
2467
1.43
0.38
42.2
17.2
29.79
30.02
pg
1.06
250
2438
250
2466
1.44
0.38
43.1
17.4
40.13
40.15
%
0.02
240
2348
250
2466
1.44
0.38
42.3
17.2
89.78
90.02
fl
0.30
250
2437
197
2029
0.88
0.36
4.3
4.1
4.79
4.76
mmol/l
0.13
187
1915
6
42
1.44
0.36
71.2
6.1
65.17
64.51
%
—
6
42
74
805
0.89
0.35
2.2
2.7
—
—
—
0
0
10
75
1.35
0.30
1.2
1.2
—
—
—
0
0
68
627
1.11
0.29
1.5
1.5
—
—
—
0
0
15
122
1.24
0.27
2.3
1.5
—
—
—
0
0
15
122
1.24
0.27
2.3
1.5
—
—
—
0
0
12
95
1.28
0.26
1.5
1.5
—
—
—
0
0
5
72
0.69
0.26
1.2
1.5
—
—
—
0
0
15
123
1.23
0.26
2.3
1.5
—
—
—
0
0
203
1985
1.11
0.24
37.9
14.9
331.74
332.67
g/l
0.69
203
1978
12
147
0.81
0.24
2.2
1.7
—
—
—
0
0
14
116
1.22
0.22
2.4
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
217.98
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
3.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.3
2.0
—
—
—
0
0
28
310
0.89
0.18
3.5
4.4
2.11
1.72
ug/l
0.17
21
276
5
70
0.71
0.17
1.2
1.4
—
—
—
0
0
5
70
0.71
0.17
1.2
1.5
—
—
—
0
0
8
68
1.18
0.17
1.0
1.3
—
—
—
0
0
11
93
1.19
0.14
2.3
2.2
—
—
—
0
0
14
122
1.16
0.14
2.4
1.5
—
—
—
0
0
5
48
1.04
0.09
85.0
6.3
—
—
—
0
0
6
54
1.11
0.09
1.5
2.6
—
—
—
0
0
9
86
1.05
0.07
2.3
1.5
—
—
—
0
0
9
100
0.90
0.06
2.7
3.0
—
—
—
0
0
27
268
1.01
0.00
1.6
1.8
—
—
—
0
0
23
227
1.01
0.00
1.7
1.9
—
—
—
0
0
14
137
1.02
0.00
1.1
1.1
—
—
—
0
0
11
106
1.04
0.00
1.3
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
4.66
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.8
2.8
1.98
5.18
u/ml
—
5
52

Mortality – FinRegistry

↥

Association

Association between endpoint D3_COMPLEMENTDEF and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_COMPLEMENTDEF.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: D3_COMPLEMENTDEF – Defects in the complement system

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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