No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
250 |
4. Check minimum number of eventsNone |
250 |
5. Include endpointsNone |
250 |
6. Filter based on genotype QC (FinnGen only) |
250 |
Control definitions (FinnGen only)
- Control exclude
- D3_IMMUNEMECHANISM
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D84
- Name in latin
- Deficientia systematis complementi
Similar endpoints
↥List of similar endpoints to
Defects in the complement system
based on the number of shared cases.
Similar with more cases:
- Other immunodeficiencies
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1516 | 980 | 531 |
| Only index persons | 1328 | 892 | 436 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.99 | 41.26 | 28.98 |
| Only index persons | 40.75 | 42.47 | 37.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 250 | 187 | 63 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | 45.47 | 45.49 | 45.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 221
- Matched controls
- 2209
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D84.18
ICD-10 Finland
Other specified defect in the complement system
+∞
116.2
101
*
D84.1
ICD-10 Finland
Defects in the complement system
+∞
69.5
63
*
D84.19
ICD-10 Finland
Unspecified defect in the complement system
+∞
63.7
58
*
T78.3
ICD-10 Finland
Angioneurotic oedema
101.2
50.6
54
7
H02AB06
ATC
prednisolone; systemic
6.8
37.5
163
646
D84.11
ICD-10 Finland
Hereditary angioedema type I
+∞
34.3
32
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.4
30.4
140
535
338
Kela drug reimbursment
C1-esterase inhibitor, icatibant and conestat alfa
+∞
29.9
28
*
D84.13
ICD-10 Finland
Hereditary angioedema type III
+∞
27.7
26
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
12.4
27.4
51
52
B06AC02
ATC
icatibant; parenteral
+∞
25.5
24
*
D80.3
ICD-10 Finland
Selective deficiency of immunoglobulin G [IgG] subclasses
+∞
24.4
23
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.8
23.7
102
336
R03DC03
ATC
montelukast; oral
5.4
23.2
83
223
C01CA24
ATC
epinephrine; parenteral
8.4
23.1
54
82
ZX120
NOMESCO Finland
Intravenous
7.1
21.4
56
100
120
Kela drug reimbursment
Hypogammaglobulinaemia
+∞
21.2
20
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
+∞
20.1
19
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
+∞
20.1
19
*
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
+∞
20.1
19
*
B02AA02
ATC
tranexamic acid; systemic
4.8
19.4
76
219
H02AB09
ATC
hydrocortisone; systemic
11.5
17.6
33
33
WW200
NOMESCO Finland
Immunization
15.8
17.3
28
20
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
16.2
63
177
TPH04
NOMESCO Finland
Cathetrisation of vein
4.0
15.6
74
249
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
9.8
15.3
31
36
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
11.7
15.2
28
27
UJF32
NOMESCO Finland
Coloscopy
3.8
14.9
76
268
D80.8
ICD-10 Finland
Other immunodeficiencies with predominantly antibody defects
+∞
14.7
14
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
3.8
14.7
75
264
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
6.0
14.1
40
78
H02AB07
ATC
prednisone; oral
4.4
14.0
56
159
R50.9
ICD-10 Finland
Fever, unspecified
4.0
13.9
63
201
D84.12
ICD-10 Finland
Hereditary angioedema type II
+∞
13.7
13
*
J01MA14
ATC
moxifloxacin; systemic
5.9
13.6
39
77
J45.0
ICD-10 Finland
Predominantly allergic asthma
4.7
13.4
48
122
J45.9
ICD-10 Finland
Asthma, unspecified
3.6
13.4
71
258
XQ800
NOMESCO Finland
Prick test
4.7
12.9
47
121
R03AK06
ATC
salmeterol and fluticasone; inhalant
4.2
12.8
53
155
R60.9
ICD-10 Finland
Oedema, unspecified
8.9
12.8
27
34
R03AC02
ATC
salbutamol; inhalant
2.9
12.7
151
940
UDH02
NOMESCO Finland
Rhinopharyngoscopy
6.3
12.6
34
62
J47
ICD-10 Finland
Bronchiectasis
22.9
12.2
17
8
TDM10
NOMESCO Finland
Puncture of maxillary antrum
7.9
12.0
27
38
R60.0
ICD-10 Finland
Localized oedema
4.9
11.7
40
96
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.8
11.6
107
557
D84.9
ICD-10 Finland
Immunodeficiency, unspecified
+∞
11.6
11
*
J01FA06
ATC
roxithromycin; oral
2.8
11.6
101
508
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.5
11.5
22
23
J45.1
ICD-10 Finland
Nonallergic asthma
4.9
11.5
39
93
R06AE07
ATC
cetirizine; oral
2.7
11.4
124
711
H02AB04
ATC
methylprednisolone; systemic
3.7
11.2
53
173
R06.0
ICD-10 Finland
Dyspnoea
3.1
11.2
71
290
WZC30
NOMESCO Finland
Teaching
3.9
11.1
48
145
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.4
10.8
59
216
X59
ICD-10 Finland
Exposure to unspecified factor
3.1
10.6
68
279
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
4.4
10.5
39
102
B06AC05
ATC
lanadelumab; parenteral
+∞
10.5
10
*
B06AC01
ATC
c1-inhibitor, plasma derived; parenteral
+∞
10.5
10
*
T78.4
ICD-10 Finland
Allergy, unspecified
5.9
10.4
29
55
R03BB04
ATC
tiotropium bromide; inhalant
5.5
10.4
31
64
J01MA02
ATC
ciprofloxacin; systemic
2.7
10.3
91
451
J31.0
ICD-10 Finland
Chronic rhinitis
4.5
10.3
37
94
UJF92
NOMESCO Finland
Capsular endoscopy
9.9
10.3
20
22
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.2
10.0
31
67
R06AE09
ATC
levocetirizine; oral
3.3
9.8
55
204
R01AD08
ATC
fluticasone; nasal
2.7
9.8
85
417
R06AX27
ATC
desloratadine; oral
2.6
9.7
95
496
WX408
NOMESCO Finland
General anesthesy, balanced
2.7
9.7
82
395
UJF30
NOMESCO Finland
Ileoscopy through colon
4.2
9.6
37
100
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.3
9.5
36
96
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
3.1
9.3
55
211
X57
ICD-10 Finland
Unspecified privation
12.2
9.2
16
14
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.2
9.1
28
60
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
9.0
142
945
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
3.2
9.0
50
184
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
11.4
8.9
16
15
L50.9
ICD-10 Finland
Urticaria, unspecified
6.3
8.9
23
40
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
8.9
62
265
C03CA01
ATC
furosemide; systemic
3.1
8.8
52
197
J01MA12
ATC
levofloxacin; systemic
3.1
8.8
52
198
R03BA02
ATC
budesonide; inhalant
2.9
8.7
59
247
ZXA10
NOMESCO Finland
Bilateral
3.0
8.7
53
207
Z31.5
ICD-10 Finland
Genetic counselling
4.5
8.7
31
78
A02BC01
ATC
omeprazole; systemic
2.7
8.6
72
340
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
8.6
78
385
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
28.8
8.6
11
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
5.0
8.3
26
57
J01FA10
ATC
azithromycin; systemic
2.4
8.3
156
1107
C08DA01
ATC
verapamil; systemic
10.6
8.2
15
15
6BA02
NOMESCO Finland
NA
34.7
8.1
10
*
J05AB11
ATC
valaciclovir; oral
3.2
8.1
44
157
G47.3
ICD-10 Finland
Sleep apnoea
2.9
8.1
52
210
R51.80
ICD-10 Finland
Headache
2.9
8.0
54
222
UGC12
NOMESCO Finland
Flexible bronchoscopy
5.5
8.0
23
46
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
4.9
7.9
25
56
P01BA02
ATC
hydroxychloroquine; oral
3.8
7.9
33
97
N06AX21
ATC
duloxetine; oral
3.4
7.8
39
132
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.5
7.8
70
343
R53
ICD-10 Finland
Malaise and fatigue
2.7
7.7
56
243
J01FF01
ATC
clindamycin; systemic
2.5
7.6
71
353
R03AK08
ATC
formoterol and beclometasone; inhalant
6.4
7.6
19
32
R03BA05
ATC
fluticasone; inhalant
2.6
7.6
62
287
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
7.5
57
252
L04AB04
ATC
adalimumab; parenteral
9.9
7.4
14
15
M25.5
ICD-10 Finland
Pain in joint
2.4
7.4
75
389
G03XA01
ATC
danazol; oral
+∞
7.3
7
*
4AA12
NOMESCO Finland
NA
31.1
7.2
9
*
L04AX01
ATC
azathioprine; systemic
5.5
7.1
20
39
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.5
7.0
32
101
J45
ICD-10 Finland
Asthma
3.3
7.0
35
119
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.3
7.0
25
64
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
7.1
7.0
16
24
A01AB09
ATC
miconazole; local oral
3.5
6.9
32
102
B34.9
ICD-10 Finland
Viral infection, unspecified
6.0
6.9
18
32
XF400
NOMESCO Finland
ECG with 12 standard connections
2.9
6.9
45
180
R01AD09
ATC
mometasone; nasal
2.1
6.8
117
767
R03AK07
ATC
formoterol and budesonide; inhalant
2.5
6.8
60
289
R03DA04
ATC
theophylline; systemic, rectal
6.3
6.8
17
29
V18
ICD-10 Finland
Pedal cyclist injured in noncollision transport accident
23.3
6.7
9
*
R03BA08
ATC
ciclesonide; inhalant
3.6
6.7
29
88
N05BA01
ATC
diazepam; systemic, rectal
3.0
6.7
38
141
XA800
NOMESCO Finland
Neuropsychological investigation
4.8
6.7
21
47
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
3.1
6.7
37
134
L50.8
ICD-10 Finland
Other urticaria
9.1
6.6
13
15
K50.9
ICD-10 Finland
Crohn disease, unspecified
10.5
6.6
12
12
N02AX02
ATC
tramadol; systemic, rectal
2.2
6.6
90
532
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
6.6
28
84
A06AC01
ATC
ispaghula (psylla seeds); oral
2.5
6.5
57
273
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
5.2
6.5
19
39
N03AX16
ATC
pregabalin; oral
2.5
6.5
58
279
H25.9
ICD-10 Finland
Senile cataract, unspecified
71.8
6.5
7
*
C08CA01
ATC
amlodipine; oral
2.4
6.4
62
313
J32.9
ICD-10 Finland
Chronic sinusitis, unspecified
18.7
6.3
9
5
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
4.3
6.3
22
55
D80.0
ICD-10 Finland
Hereditary hypogammaglobulinaemia
+∞
6.3
6
*
D84.8
ICD-10 Finland
Other specified immunodeficiencies
+∞
6.3
6
*
D80.2
ICD-10 Finland
Selective deficiency of immunoglobulin A [IgA]
+∞
6.3
6
*
D84.14
ICD-10 Finland
C1 esterase inhibitor deficiency (C1-INH deficiency)
+∞
6.3
6
*
J06.80
ICD-10 Finland
Continuously repeating infections of a child
27.5
6.3
8
*
R42
ICD-10 Finland
Dizziness and giddiness
2.6
6.2
48
214
M79.7
ICD-10 Finland
Fibromyalgia
5.2
6.2
18
37
M79.0
ICD-10 Finland
Rheumatism, unspecified
5.2
6.2
18
37
A06AD11
ATC
lactulose; oral
3.4
6.2
29
94
E0000UV
ATC
NA
2.0
6.2
104
668
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
5.5
6.2
17
33
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
13.0
6.1
10
8
N03AX12
ATC
gabapentin; oral
2.7
6.1
42
177
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.3
6.0
29
96
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
103
77
22.05
117.35
2.4
1.4
0.2
0.2
g/l
3.52
86
77
111
162
11.52
79.82
7.2
2.2
9.4
10.0
g/l
0.66
106
153
44
16
33.16
66.14
2.5
1.3
—
—
—
0
0
34
8
48.92
28.55
1.4
1.0
—
—
—
0
0
70
207
4.31
21.81
3.5
2.1
316.8
361.5
nmol/l
0.90
65
193
203
1234
4.43
20.86
17.1
9.5
4.0
3.9
e9/l
0.40
198
1064
26
31
9.24
20.51
4.6
3.2
58.8
59.1
%
0.03
26
31
26
31
9.24
20.51
4.7
2.6
4.2
4.9
e9/l
0.55
26
31
29
40
8.07
20.37
1.6
1.7
—
—
—
0
0
23
7
35.97
18.31
3.0
1.3
786.8
1447.7
u/ml
—
23
7
59
176
4.08
17.91
2.5
1.6
—
—
—
0
0
59
177
4.05
17.76
2.3
1.5
—
—
—
0
0
72
248
3.67
17.76
3.4
1.7
—
—
—
0
0
26
41
6.96
16.17
2.4
1.7
—
—
—
0
0
24
36
7.27
15.60
2.4
2.1
—
—
—
0
0
16
14
12.14
15.46
4.8
2.9
—
—
—
0
0
35
79
4.99
15.02
2.0
1.7
—
—
—
0
0
147
835
2.85
14.63
15.6
7.3
1.2
1.2
mmol/l
1.57
136
764
22
33
7.21
14.27
1.7
1.8
—
—
—
0
0
147
850
2.77
13.89
3.5
2.5
77.4
74.1
nmol/l
0.69
139
767
127
687
2.72
13.63
6.2
3.2
—
—
—
0
0
41
120
3.89
12.57
2.6
1.5
—
—
—
0
0
95
460
2.72
12.47
5.5
2.4
2.9
2.9
mg/l
0.04
90
399
23
42
5.93
12.36
1.3
1.3
—
—
—
0
0
23
42
5.93
12.36
1.3
1.3
—
—
—
0
0
151
919
2.62
12.35
11.5
7.2
1.2
1.2
mmol/l
0.57
130
794
20
32
6.71
12.20
1.1
1.3
1.6
1.5
u/ml
—
9
11
66
276
2.89
11.33
6.6
4.9
0.8
0.8
mmol/l
1.00
66
263
207
1511
3.15
11.26
15.2
6.7
78.0
82.1
u/l
0.71
201
1411
18
28
6.85
11.25
1.4
1.6
—
—
—
0
0
168
1112
2.56
10.98
11.0
4.7
6.3
6.4
mmol/l
0.54
163
1022
14
5
29.51
10.84
1.8
1.0
11.8
11.6
u/l
—
14
5
209
1548
3.13
10.79
11.2
3.9
11.9
9.9
mm/h
1.50
203
1439
16
23
7.36
10.70
1.4
1.7
—
—
—
0
0
128
757
2.42
10.62
8.6
4.8
36.3
36.7
g/l
0.37
121
712
155
1001
2.44
10.50
7.8
6.1
11.6
12.3
umol/l
0.16
145
942
31
85
4.02
10.34
2.3
1.6
—
—
—
0
0
16
24
7.05
10.31
1.1
1.7
—
—
—
0
0
64
281
2.72
9.91
4.0
2.4
11.6
14.2
umol/l
2.62
64
259
98
528
2.41
9.87
3.4
2.0
121.9
153.7
u/l
0.74
93
508
80
397
2.49
9.61
3.8
3.3
491.0
815.2
ng/l
1.22
68
327
32
96
3.68
9.40
2.4
1.3
—
—
—
0
0
13
18
7.56
8.93
3.4
2.1
—
—
—
0
0
13
18
7.56
8.93
3.4
2.1
—
—
—
0
0
13
18
7.56
8.93
3.4
2.1
—
—
—
0
0
17
32
5.63
8.81
1.1
1.1
—
—
—
0
0
14
22
6.68
8.62
2.4
2.1
—
—
—
0
0
13
19
7.16
8.52
1.5
1.7
—
—
—
0
0
18
37
5.16
8.50
1.2
1.3
3.3
4.2
u/ml
—
8
18
96
541
2.26
8.47
5.6
3.1
0.7
0.3
e6/l
0.29
84
382
16
30
5.63
8.32
2.9
2.1
16.8
17.1
%
—
9
14
14
23
6.39
8.27
1.4
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
36
4.99
7.76
2.6
9.7
0.3
0.4
u/ml
0.36
12
21
22
59
3.99
7.53
1.7
1.3
7.8
49.1
u/ml
—
6
6
81
447
2.20
7.35
3.3
2.3
0.9
1.1
mg/l
0.30
71
335
12
19
6.58
7.31
1.2
1.5
—
—
—
0
0
50
225
2.53
7.22
14.5
6.4
1.6
1.6
mmol/l
0.03
43
170
39
157
2.76
7.01
4.2
3.0
—
—
—
0
0
50
229
2.48
6.94
4.1
4.2
4.5
7.5
umol/l
1.19
41
203
29
101
3.12
6.73
21.0
4.7
1.6
1.2
%
0.70
29
101
64
335
2.22
6.53
3.6
3.0
0.8
0.8
e6/l
0.01
44
183
14
29
5.05
6.53
2.4
1.9
—
—
—
0
0
24
78
3.30
6.23
1.5
1.3
—
—
—
0
0
105
673
1.97
6.18
2.2
1.8
98.9
96.8
pmol/l
0.18
60
333
41
181
2.51
6.12
10.1
11.4
24.5
24.8
mmol/l
0.28
41
181
20
59
3.60
6.00
6.2
1.5
5.6
3.6
g/l
0.66
15
49
20
59
3.60
6.00
6.1
1.5
—
—
—
0
0
52
261
2.25
5.83
1.7
1.7
1510.2
1144.6
nmol/l
1.63
42
200
19
56
3.59
5.71
1.7
1.6
0.0
0.1
iu/ml
—
8
10
17
47
3.81
5.58
1.4
1.4
—
—
—
0
0
68
390
2.02
5.38
1.7
1.4
23.0
20.9
nmol/l
0.49
58
332
96
621
1.89
5.33
5.4
3.1
16.1
25.1
ng/l
1.11
62
344
59
323
2.08
5.29
3.5
3.1
2.2
3.0
e6/l
0.49
39
175
37
167
2.43
5.26
5.5
7.0
1.0
1.3
mmol/l
0.20
28
121
12
27
4.62
5.09
1.2
1.1
—
—
—
0
0
96
631
1.85
5.01
3.4
3.0
2.3
2.4
mmol/l
2.74
86
571
37
172
2.35
4.93
5.8
6.9
5.2
5.1
kpa
0.16
37
159
37
172
2.35
4.93
10.2
7.9
1.8
1.4
mmol/l
0.25
32
127
37
173
2.34
4.86
1.7
1.3
43.9
160.8
iu/ml
—
10
76
15
42
3.74
4.84
3.7
2.9
25.1
25.1
mmol/l
0.01
15
35
12
29
4.30
4.68
2.3
1.8
1.7
1.5
mmol/l
0.23
12
29
73
450
1.88
4.61
2.6
2.3
—
—
—
0
0
34
158
2.33
4.53
13.0
8.8
10.3
6.9
mmol/l
1.31
34
151
135
1006
1.74
4.46
6.2
3.2
0.0
0.0
estimate
0.00
29
189
22
83
2.81
4.46
1.4
1.1
—
—
—
0
0
13
35
3.86
4.42
1.7
1.1
—
—
—
0
0
56
320
1.97
4.41
3.6
3.3
75.4
375.4
ng/l
2.20
27
217
65
391
1.90
4.40
1.6
1.3
24.3
25.8
iu/ml
0.07
25
124
135
1010
1.73
4.37
7.9
4.6
0.0
0.0
estimate
0.50
30
191
55
315
1.96
4.30
2.0
1.6
76000453.4
25000450.5
pmol/l
0.28
50
268
31
142
2.35
4.26
11.3
7.3
128.4
123.2
g/l
0.69
31
137
135
1017
1.71
4.20
6.2
3.2
0.0
0.0
estimate
0.00
30
181
35
171
2.22
4.15
18.2
16.8
1.1
1.3
inr
—
8
32
32
151
2.28
4.12
3.6
2.7
63.1
70.2
ml/min/173m2
0.52
14
63
13
37
3.65
4.11
1.2
1.1
—
—
—
0
0
7
7
10.24
4.03
1.7
1.6
11.1
9.6
umol/l
—
7
7
26
114
2.43
3.94
5.1
7.9
9.3
9.6
kpa
0.39
26
106
10
25
4.13
3.73
1.6
1.4
—
—
—
0
0
8
12
6.84
3.70
3.8
5.1
24.5
26.9
umol/l
—
8
12
11
30
3.79
3.68
1.3
1.3
—
—
—
0
0
10
28
3.68
3.23
2.9
1.5
—
—
—
0
0
8
15
5.47
3.21
1.6
1.5
—
—
—
0
0
7
11
6.51
3.20
1.1
1.4
—
—
—
0
0
104
771
1.60
3.19
6.3
3.2
—
—
—
0
0
233
2128
2.40
3.17
36.3
11.1
20.8
21.6
mg/l
0.15
198
1583
50
307
1.79
3.11
1.8
2.4
2.4
2.4
mmol/l
0.01
43
272
85
605
1.61
3.06
1.5
1.4
0.5
1.5
u/ml
2.20
28
167
36
200
1.93
3.06
1.5
1.9
—
—
—
0
0
119
918
1.57
3.04
5.0
3.9
—
—
—
0
0
20
88
2.38
3.02
3.0
1.6
—
—
—
0
0
15
57
2.74
3.02
1.9
1.5
174.9
249.8
u/ml
—
10
33
5
5
10.17
2.99
1.2
1.2
—
—
—
0
0
81
573
1.61
2.98
2.1
1.7
—
—
—
0
0
75
522
1.62
2.94
7.6
3.3
0.0
0.0
estimate
0.50
30
191
6
9
6.80
2.88
1.5
1.1
—
—
—
0
0
6
9
6.80
2.88
1.5
1.1
—
—
—
0
0
192
1673
1.64
2.74
5.1
4.0
14.4
14.5
pmol/l
0.13
181
1546
58
386
1.65
2.70
1.4
1.3
7.0
10.1
u/ml
0.30
22
162
12
43
2.88
2.68
1.3
2.3
—
—
—
0
0
7
15
4.77
2.61
1.7
1.0
—
—
—
0
0
15
62
2.51
2.59
1.7
1.5
—
—
—
0
0
6
11
5.56
2.56
1.0
1.1
—
—
—
0
0
20
96
2.18
2.50
21.6
7.0
25.7
24.7
mmol/l
0.50
20
88
8
21
3.90
2.48
2.9
1.0
—
—
—
0
0
18
84
2.23
2.41
1.2
1.5
10.4
10.8
u/l
0.03
13
59
12
46
2.69
2.39
1.1
1.1
—
—
—
0
0
8
22
3.72
2.38
2.9
1.1
—
—
—
0
0
5
8
6.35
2.38
1.2
1.5
—
—
—
0
0
8
23
3.56
2.29
1.3
1.1
—
—
—
0
0
8
23
3.56
2.29
1.6
1.2
—
—
—
0
0
8
23
3.56
2.29
1.6
1.2
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
6
13
4.70
2.28
1.2
1.8
164.2
141.9
%
—
6
13
9
29
3.18
2.25
1.7
1.2
—
—
—
0
0
5
9
5.64
2.22
4.0
2.2
—
—
—
0
0
5
9
5.64
2.22
4.0
2.2
—
—
—
0
0
5
9
5.64
2.22
2.4
1.6
4.4
3.0
mg/l
—
5
9
5
9
5.64
2.22
4.0
2.2
—
—
—
0
0
5
9
5.64
2.22
1.2
1.4
—
—
—
0
0
8
24
3.41
2.20
1.6
1.2
—
—
—
0
0
8
24
3.41
2.20
1.6
1.2
—
—
—
0
0
8
24
3.41
2.20
1.6
1.2
—
—
—
0
0
187
1653
1.52
2.17
4.8
3.5
—
—
—
0
0
6
14
4.36
2.16
1.0
1.3
—
—
—
0
0
27
154
1.84
2.14
1.4
1.8
—
—
—
0
0
5
10
5.08
2.08
1.2
1.6
—
—
—
0
0
7
20
3.57
2.07
1.3
1.5
—
—
—
0
0
7
21
3.40
1.98
3.1
6.1
107.7
105.0
%
—
7
21
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
5
11
4.61
1.95
1.0
1.1
109.0
129.5
%
—
5
11
6
16
3.81
1.94
1.2
1.2
—
—
—
0
0
5
12
4.23
1.83
1.8
2.3
—
—
—
0
0
16
82
2.02
1.74
1.3
1.1
—
—
—
0
0
7
24
2.97
1.73
1.3
1.4
—
—
—
0
0
5
13
3.90
1.72
7.2
1.9
—
—
—
0
0
5
13
3.90
1.72
7.2
1.9
—
—
—
0
0
5
13
3.90
1.72
7.2
1.9
—
—
—
0
0
5
13
3.90
1.72
7.2
1.9
—
—
—
0
0
16
83
1.99
1.69
1.3
1.1
—
—
—
0
0
5
14
3.62
1.62
1.4
1.2
—
—
—
0
0
5
14
3.62
1.62
1.0
1.6
—
—
—
0
0
11
218
0.48
1.60
1.5
1.7
—
—
—
0
0
11
51
2.21
1.53
1.5
1.3
—
—
—
0
0
6
21
2.90
1.51
1.2
1.1
—
—
—
0
0
70
548
1.39
1.46
1.5
1.7
1.4
1.4
mmol/l
0.09
63
484
5
16
3.17
1.44
1.2
1.2
—
—
—
0
0
6
22
2.77
1.44
1.8
1.4
—
—
—
0
0
173
1884
0.73
1.41
4.0
3.6
1.4
1.3
mmol/l
1.50
163
1765
5
17
2.98
1.36
1.2
1.2
—
72.2
—
0
5
9
42
2.18
1.35
2.4
1.5
—
—
—
0
0
15
83
1.86
1.34
2.0
1.8
—
—
—
0
0
158
1411
1.33
1.33
6.0
3.2
44.6
39.0
u/l
0.56
151
1346
199
1842
1.39
1.31
25.0
10.0
88.9
88.4
ml/min/173m2
0.11
178
1486
24
156
1.60
1.25
1.0
1.0
—
—
—
0
0
209
1959
1.41
1.19
5.8
4.7
1.7
2.5
mu/l
0.64
203
1827
6
26
2.34
1.19
1.0
1.5
—
—
—
0
0
5
20
2.53
1.15
1.0
1.1
—
—
—
0
0
177
1903
0.76
1.13
4.6
3.9
5.7
5.8
mmol/l
0.13
170
1774
7
30
2.37
1.13
1.3
1.4
—
—
—
0
0
11
60
1.87
1.04
6.4
1.8
—
—
—
0
0
5
22
2.30
1.04
2.6
2.5
1.1
3.8
nmol/l
—
5
22
13
76
1.75
1.01
1.8
1.4
—
—
—
0
0
12
70
1.75
0.94
1.8
1.4
—
—
—
0
0
24
174
1.42
0.80
2.8
3.6
18.3
8.2
ug/l
0.27
17
138
15
99
1.55
0.77
2.3
2.3
0.2
0.1
e6/l
0.74
15
94
11
171
0.63
0.75
2.3
2.6
0.3
0.7
ug/l
—
6
104
189
1985
0.80
0.73
4.9
4.4
2.9
2.8
mmol/l
0.26
181
1864
5
25
2.02
0.73
3.2
1.6
—
—
—
0
0
5
25
2.02
0.73
3.2
1.6
—
—
—
0
0
5
25
2.02
0.73
3.2
1.6
—
—
—
0
0
186
1956
0.81
0.72
4.3
4.0
1.5
1.5
mmol/l
0.38
178
1835
5
26
1.94
0.71
3.2
1.6
—
—
—
0
0
5
26
1.94
0.71
3.2
1.6
—
—
—
0
0
7
41
1.73
0.70
1.3
1.2
—
—
—
0
0
10
63
1.61
0.62
8.5
2.1
—
—
—
0
0
5
30
1.68
0.61
1.0
1.6
6.0
7.3
mmol/l
—
5
21
6
99
0.60
0.53
1.3
1.4
—
—
—
0
0
20
154
1.32
0.50
1.4
1.3
—
—
—
0
0
189
1962
0.85
0.48
4.3
4.0
4.8
4.8
mmol/l
0.13
179
1850
5
37
1.36
0.37
1.6
1.2
—
—
—
0
0
6
47
1.28
0.32
1.5
1.4
34.3
21.9
u/l
—
6
38
242
2393
1.35
0.29
43.2
17.1
133.4
135.0
g/l
1.15
242
2363
7
57
1.23
0.29
1.4
1.7
—
—
—
0
0
17
202
0.83
0.26
8.6
5.2
—
—
—
0
0
20
233
0.85
0.25
2.8
3.9
20.1
20.5
%
—
5
102
6
49
1.23
0.20
1.3
1.5
—
—
—
0
0
26
288
0.89
0.17
3.5
4.3
2.1
1.7
ug/l
0.15
20
255
201
2038
0.93
0.14
30.0
12.5
40.1
40.0
%
0.03
162
1635
40
425
0.93
0.12
1.7
1.4
—
—
—
0
0
12
137
0.87
0.12
1.3
1.5
—
—
—
0
0
6
75
0.80
0.07
1.3
1.5
—
—
—
0
0
6
75
0.80
0.07
1.3
1.5
—
—
—
0
0
6
75
0.80
0.07
1.3
1.5
—
—
—
0
0
7
83
0.84
0.07
1.1
1.6
—
—
—
0
0
9
88
1.02
0.07
2.8
1.7
—
—
—
0
0
35
356
0.98
0.00
2.5
2.1
—
—
—
0
0
32
319
1.00
0.00
2.4
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
6.3
—
—
—
0
0
6
68
0.88
0.00
1.7
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
2.9
—
2.5
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint D3_COMPLEMENTDEF and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_COMPLEMENTDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_COMPLEMENTDEF – Defects in the complement system
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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