This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

E4_DYSPOLYGL

Polyglandular hyperfunction

Endpoint Browser

E4_POLYHYPER

No definition available.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E31.1 Cause of death: ICD-10 — E31.1 2 out of 7 registries used, show all original rules.	12
4. Check minimum number of events None	12
5. Include endpoints None	12
6. Filter based on genotype QC (FinnGen only)	12

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E31
Name in latin: Hyperfunctio polyglandularis

NAME	E4_POLYHYPER
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E311
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E311
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Polyglandular hyperfunction based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	59	35	23
Only index persons	55	34	21
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	44.86	45.00	44.21
Only index persons	41.85	41.31	42.73

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	12	11	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	56.14	57.36	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3035637) Corticotropin [Mass/volume] in Plasma

+∞

6.85

1.8

0.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

+∞

5.59

7.8

0.0

1.7

—

nmol/l

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

18.65

4.49

4.3

1.3

406.6

354.1

nmol/l

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

18.04

4.00

4.7

1.7

338.7

309.3

mu/l

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

12.16

3.66

14.9

1.8

1.1

mmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

11.10

2.84

4.0

2.7

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

7.64

2.32

3.6

13.1

5.3

4.8

kpa

—

(3027801) Oxygen [Partial pressure] in Arterial blood

7.64

2.32

3.0

13.1

13.6

12.7

kpa

—

(40761536) Microorganisms panel - Urine sediment

5.76

1.93

2.0

4.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

4.57

1.62

2.2

1.7

—

(3003338) MCHC [Mass/volume]

0.31

1.12

45.5

17.9

322.3

332.0

g/l

—

(3026008) Bacteria identified in Urine by Culture

2.24

0.65

4.9

3.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.87

0.49

2.2

3.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

0.56

0.47

4.9

3.9

1.2

1.3

mmol/l

—

(3000494) Fungus identified in Specimen by Culture

0.00

0.45

0.0

1.5

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.44

0.0

1.3

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

0.57

0.42

1.6

2.0

21.2

50.2

u/l

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

0.63

0.28

18.0

5.5

82.1

72.9

u/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.42

0.27

3.0

2.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.65

0.26

8.4

3.6

—

(3022096) Basophils/100 leukocytes in Blood

1.44

0.26

2.3

4.1

0.7

0.6

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.22

0.0

1.1

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.22

0.0

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.22

0.0

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.22

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.22

0.0

1.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.22

0.0

1.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.4

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.22

0.0

1.4

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.22

0.0

1.4

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.22

0.0

2.8

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.22

0.0

1.9

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.22

0.0

6.9

—

(3019069) Monocytes/100 leukocytes in Blood

1.40

0.12

2.3

4.3

9.2

8.0

—

(3006504) Eosinophils/100 leukocytes in Blood

1.40

0.12

2.3

4.2

2.0

2.2

—

(3003694) ABO and Rh group [Type] in Blood

1.19

0.12

1.8

—

(3002030) Lymphocytes/100 leukocytes in Blood

1.26

0.12

2.3

4.1

27.0

28.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

0.79

0.11

11.2

4.2

9.5

9.2

umol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

1.22

0.11

7.1

12.5

4.7

4.8

e9/l

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.0

1.2

—

(3036489) Thrombin time

0.00

0.0

1.2

—

20.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.1

—

(3001604) Monocytes [#/volume] in Blood

1.18

0.00

2.3

3.9

0.6

e9/l

—

(3018010) Neutrophils/100 leukocytes in Blood

0.87

0.00

2.2

3.7

52.4

58.8

—

(3006315) Basophils [#/volume] in Blood

1.18

0.00

2.3

3.9

0.0

e9/l

—

(3013115) Eosinophils [#/volume] in Blood

1.10

0.00

2.5

3.9

0.1

0.2

e9/l

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

5.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

0.00

0.0

1.0

—

102.0

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

2.6

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.2

—

(4010399)

0.00

0.0

1.0

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

2.0

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

0.00

0.0

2.0

—

3.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.2

—

(3019198) Lymphocytes [#/volume] in Blood

1.03

0.00

2.3

3.6

2.0

1.9

e9/l

—

(40761535) Cells panel - Urine sediment

0.00

0.0

2.9

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.8

—

(3044889) 12 lead EKG panel

0.97

0.00

5.0

3.4

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.3

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

171.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.2

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(3015171) Extractable nuclear Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.2

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.2

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.2

—

(3019225) pH of Specimen

0.00

0.0

1.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_POLYHYPER and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_POLYHYPER.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_POLYHYPER – Polyglandular hyperfunction

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Polyglandular hyperfunction

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints