No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
78 |
4. Check minimum number of eventsNone |
78 |
5. Include endpoints |
88 |
6. Filter based on genotype QC (FinnGen only) |
88 |
Control definitions (FinnGen only)
- Control exclude
- E4_ENDOGLAND
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E20-E35
- Name in latin
- Dysfunctio polyglandularis (endocrina)
Similar endpoints
↥List of similar endpoints to
Polyglandular dysfunction
based on the number of shared cases.
Similar with more cases:
- Disorders of other endocrine glands
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 523 | 320 | 196 |
| Only index persons | 419 | 270 | 149 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 38.73 | 38.37 | 38.89 |
| Only index persons | 35.72 | 35.52 | 36.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 88 | 59 | 29 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 33.88 | 37.10 | 27.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 73
- Matched controls
- 730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02AB09
ATC
hydrocortisone; systemic
175.3
31.6
31
*
H02AA02
ATC
fludrocortisone; oral
+∞
30.3
27
*
105
Kela drug reimbursment
Adrenal cortical hypofunction
+∞
29.1
26
*
E27.1
ICD-10 Finland
Primary adrenocortical insufficiency
+∞
25.5
23
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
32.5
23.5
31
16
E31.00
ICD-10 Finland
APECED syndrome
+∞
23.1
21
*
A11CC03
ATC
alfacalcidol; systemic
69.8
21.8
24
5
A10AE05
ATC
insulin detemir; parenteral
27.5
20.3
28
16
106
Kela drug reimbursment
Hypoparathyroidism
+∞
19.7
18
*
A12AA04
ATC
calcium carbonate; oral
126.1
18.5
19
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
18.1
17.5
28
24
H03AA01
ATC
levothyroxine sodium; systemic
8.9
16.4
45
111
E31.08
ICD-10 Finland
Autoimmune polyglandular failure
+∞
16.2
15
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
18.3
15.9
25
20
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
29.9
15.2
20
9
103
Kela drug reimbursment
Diabetes, insulin-treated
8.3
15.0
41
97
T89
ICPC
Diabetes insulin dependent
22.1
14.5
21
13
A10AE04
ATC
insulin glargine; parenteral
11.9
14.4
28
36
215
Kela drug reimbursment
Diabetes, non-insulin-treated
7.9
14.1
39
92
E31.9
ICD-10 Finland
Polyglandular dysfunction, unspecified
+∞
14.0
13
*
E83.51
ICD-10 Finland
Hypocalcemia
155.7
12.9
13
*
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
21.2
12.4
18
11
A11CC02
ATC
dihydrotachysterol; oral
+∞
11.8
11
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
42.5
11.7
14
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
6.3
11.1
36
98
H04AA01
ATC
glucagon; nasal, parenteral
20.0
11.0
16
10
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
38.9
10.7
13
*
E34.9
ICD-10 Finland
Endocrine disorder, unspecified
+∞
9.6
9
*
A12AA06
ATC
calcium lactate gluconate; oral
+∞
9.6
9
*
E31.1
ICD-10 Finland
Polyglandular hyperfunction
+∞
9.6
9
*
25810
ICD-8 Finland
Polyglandular dysfunction and other diseases of endocrine glands, Polyglandular dysfunction
+∞
9.6
9
*
104
Kela drug reimbursment
Thyroid insufficiency
11.0
9.5
18
21
A07AA02
ATC
nystatin; oral
11.9
9.4
17
18
XCK10
NOMESCO Finland
Photography of fundus of eye
8.5
9.4
21
33
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
22.2
9.3
13
7
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
19.4
8.9
13
8
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
57.1
8.9
10
*
E03.89
ICD-10 Finland
Other specified hypothyroidism
31.8
8.8
11
*
E31.01
ICD-10 Finland
Schmidt's syndrome
+∞
8.5
8
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
+∞
8.5
8
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
20.1
8.4
12
7
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
38.0
8.3
10
*
E87.6
ICD-10 Finland
Hypokalaemia
38.0
8.3
10
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.5
8.3
37
135
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
6.5
8.2
22
45
A10AA01
ATC
NA
21.2
7.9
11
6
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.3
7.9
38
147
A09AA02
ATC
multienzymes (lipase, protease etc.)
28.5
7.8
10
*
C03CA01
ATC
furosemide; systemic
4.8
7.6
28
83
2581B
ICD-9 Finland
Polyglandular dysfunction and related disorders, Other combinations of endocrine dysfunction[AUTOIMMUNE-POLYENDOCRINOPATHY-CANDIDOSIS-ECTOD DYST]
+∞
7.4
7
*
E31.8
ICD-10 Finland
Other polyglandular dysfunction
+∞
7.4
7
*
E31.0
ICD-10 Finland
Autoimmune polyglandular failure
+∞
7.4
7
*
25510
ICD-8 Finland
Diseases of adrenal glands, Adrenal cortical hypofunction
+∞
7.4
7
*
2581A
ICD-9 Finland
Polyglandular dysfunction and related disorders, Other combinations of endocrine dysfunction[SYNDROMA SCHMIDT]
+∞
7.4
7
*
SPAT1262
SPAT
Handing over of treatment supplies
5.1
7.4
25
67
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
33.7
7.3
9
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
12.8
7.1
12
11
J01MA12
ATC
levofloxacin; systemic
5.4
7.0
22
54
A10AA02
ATC
NA
19.0
7.0
10
6
H3601, E103
ICD-10 Finland
NA
44.2
6.9
8
*
E83.50
ICD-10 Finland
Hypercalcemia
44.2
6.9
8
*
A10AE06
ATC
insulin degludec; parenteral
16.3
6.6
10
7
D44.8
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pluriglandular involvement
76.2
6.5
7
*
107
Kela drug reimbursment
Pernicious anaemia
20.2
6.4
9
5
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
4.7
6.4
23
65
Z01.8
ICD-10 Finland
Other specified special examinations
4.2
6.3
26
84
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
+∞
6.3
6
*
E27.2
ICD-10 Finland
Addisonian crisis
+∞
6.3
6
*
L03.0
ICD-10 Finland
Cellulitis of finger and toe
7.6
6.2
14
22
121
Kela drug reimbursment
Severe hypofunction of sexual glands
16.8
6.1
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
unit
cases
controls
-log10(p)
N cases
N controls
(1616796) Gas panel - Central venous blood
16
10
19.33
18.98
8.9
1.5
—
—
—
0
0
(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood
28
45
8.66
17.99
17.2
3.1
mmol/l
1.2
1.2
0.61
28
39
(3018418) pH of Serum or Plasma
57
191
6.63
17.46
23.2
4.4
ph
7.4
7.4
0.61
25
34
(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma
71
296
8.24
16.94
32.7
9.3
mmol/l
1.2
1.2
2.86
59
252
(3020682) Albumin/Creatinine [Ratio] in Urine
50
176
5.26
13.70
7.4
4.0
mg/mmol
17.1
8.2
0.49
33
107
(3013290) Carbon dioxide [Partial pressure] in Blood
15
15
11.85
13.51
10.3
1.4
kpa
5.3
5.0
0.48
15
15
(3027315) Oxygen [Partial pressure] in Blood
15
15
11.85
13.51
10.3
1.4
kpa
9.0
9.5
0.31
15
15
(3012516) Albumin [Mass/volume] in Urine
48
166
5.16
13.38
5.6
3.1
mg/l
87.9
52.6
0.29
35
101
(3009508) Creatinine [Moles/volume] in Urine
52
200
4.91
12.49
6.1
2.9
mmol/l
6.4
7.7
0.97
45
178
(3016293) Bicarbonate [Moles/volume] in Serum or Plasma
20
34
7.32
11.93
11.3
8.4
mmol/l
26.2
25.5
0.21
20
34
(3003181) Sodium [Moles/volume] in Urine
12
11
12.47
11.31
1.3
1.2
mmol/l
84.6
62.5
0.53
12
11
(40763571) Iron/Transferrin [Ratio] in Serum or Plasma
29
75
5.28
11.21
6.3
2.2
%
21.6
21.6
0.00
24
63
(3032080) INR in Blood by Coagulation assay
53
232
4.23
10.16
13.5
6.5
inr
1.2
1.2
0.20
24
72
(43054903) Holo-transcobalamin II [Moles/volume] in Serum
52
226
4.18
10.04
4.2
1.9
pmol/l
98.6
100.6
0.11
36
109
(3012544) pH of Venous blood
21
48
5.43
9.20
5.9
7.4
—
—
—
0
0
(3021447) Carbon dioxide [Partial pressure] in Venous blood
21
49
5.32
8.98
7.0
6.9
kpa
5.9
5.8
0.18
21
49
(3021440) Promyelocytes/100 leukocytes in Blood
22
55
5.00
8.68
4.7
3.5
%
0.1
0.3
—
9
18
(3023368) Bacteria identified in Blood by Culture
40
158
3.81
8.60
7.1
3.9
—
—
—
0
0
(3000991) Gas panel - Venous blood
20
47
5.21
8.46
9.1
7.7
—
—
—
0
0
(40768797) Stomach Pathology biopsy report
28
87
4.25
8.41
1.4
1.2
—
—
—
0
0
(3017181) Myelocytes/100 leukocytes in Blood
22
61
4.48
7.60
4.8
3.4
%
1.1
0.9
—
9
21
(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma
10
5
22.25
7.31
8.2
1.2
—
—
—
0
0
(3002179) Metamyelocytes/100 leukocytes in Blood
20
53
4.59
7.29
5.1
3.2
%
0.7
0.7
—
7
9
(3025159) Blasts/100 leukocytes in Blood
19
50
4.57
6.97
5.2
3.7
%
0.0
0.0
—
7
13
(3014702) Chromogranin A [Moles/volume] in Serum or Plasma
10
6
18.54
6.92
7.2
3.7
nmol/l
2.1
1.1
—
10
6
(3022806) Fractional oxyhemoglobin in Capillary blood
10
8
13.89
6.25
3.0
1.3
%
90.6
89.7
—
10
8
(3021901) Oxygen saturation in Capillary blood
10
8
13.89
6.25
3.2
1.6
—
—
—
0
0
(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum
40
188
3.07
6.12
1.9
1.4
u/ml
0.8
2.1
0.58
11
48
(3009340) Metanephrine [Moles/volume] in Serum or Plasma
9
6
16.48
6.04
2.1
1.2
nmol/l
—
—
—
0
0
(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture
20
61
3.95
6.02
4.1
3.1
—
—
—
0
0
(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma
9
7
14.12
5.72
2.6
1.1
—
—
—
0
0
(3026389) Candida sp identified in Specimen by Organism specific culture
8
5
17.38
5.52
4.6
1.4
—
—
—
0
0
(3023436) Glucagon [Mass/volume] in Serum or Plasma
5
0
+∞
5.25
2.0
0.0
ng/l
150.6
—
—
5
0
(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum
14
36
4.44
5.22
1.6
1.1
—
—
—
0
0
(42870588) Differential panel, method unspecified - Blood
42
223
2.69
4.90
10.8
6.2
—
—
—
0
0
(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection
25
101
3.06
4.84
3.6
1.8
—
—
—
0
0
(40761536) Microorganisms panel - Urine sediment
19
65
3.45
4.80
6.7
3.2
—
—
—
0
0
(3016244) Insulin [Units/volume] in Serum or Plasma
7
5
15.03
4.65
3.9
4.0
mu/l
15.6
5.9
—
7
5
(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count
42
231
2.57
4.47
7.9
2.8
—
—
—
0
0
(3007853) Bacteria identified in Skin by Aerobe culture
19
68
3.29
4.46
3.2
1.6
—
—
—
0
0
(3007164) IgA [Mass/volume] in Serum or Plasma
36
186
2.58
4.33
1.9
1.4
g/l
2.8
2.3
0.72
21
114
(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells
9
13
7.57
4.28
1.7
2.5
—
—
—
0
0
(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability
6
5
12.73
3.82
1.7
1.2
—
—
—
0
0
(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood
10
25
4.38
3.81
8.3
4.2
%
62.0
51.4
—
10
25
(3032035) Polymorphonuclear cells/100 leukocytes in Blood
8
12
7.20
3.76
10.3
1.5
%
60.0
57.2
—
8
12
(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection
13
41
3.55
3.66
1.7
1.5
—
—
—
0
0
(3013115) Eosinophils [#/volume] in Blood
56
374
2.37
3.65
9.8
6.6
e9/l
0.2
0.2
0.25
51
342
(40760888) Immunoglobulin light chains.free panel - Serum
7
9
8.33
3.63
1.1
10.1
—
—
—
0
0
(3004588) Protein electrophoresis panel - Serum or Plasma
11
31
3.91
3.61
1.5
5.4
—
—
—
0
0
(36304419) Bacteria [Presence] in Urine
33
178
2.37
3.51
6.4
2.7
—
—
—
0
0
(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection
10
27
4.05
3.46
2.2
1.7
—
—
—
0
0
(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma
40
237
2.26
3.40
5.4
3.8
ng/l
24.6
18.5
0.58
31
142
(3026008) Bacteria identified in Urine by Culture
36
206
2.27
3.31
4.7
2.9
—
—
—
0
0
(3029937) Albumin [Presence] in Urine by Test strip
35
198
2.27
3.30
6.0
3.9
estimate
0.0
0.0
0.00
18
73
(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood
10
28
3.90
3.30
5.3
7.8
%
2.0
1.1
—
10
28
(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection
7
11
6.80
3.25
3.4
1.9
—
—
—
0
0
(3002173) Hemoglobin [Mass/volume] in Arterial blood
15
57
2.97
3.15
10.4
16.9
g/l
114.1
123.6
1.24
15
57
(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection
9
21
4.65
3.09
1.3
1.1
—
—
—
0
0
(3030905) Polymorphonuclear cells [#/volume] in Blood
7
12
6.23
3.08
9.1
1.5
e9/l
4.6
4.7
—
7
12
(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection
7
12
6.23
3.08
3.4
2.1
—
—
—
0
0
(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma
5
5
10.49
3.01
4.4
1.2
ug/l
12.4
16.9
—
5
5
(3004490) Bicarbonate [Moles/volume] standard in Capillary blood
10
30
3.63
3.01
17.5
3.4
mmol/l
25.5
25.5
—
10
30
(3018405) Lactate [Moles/volume] in Arterial blood
9
22
4.43
2.97
8.8
4.8
mmol/l
1.3
1.5
—
9
22
(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma
29
158
2.25
2.95
3.1
3.7
ng/l
1275.8
850.9
0.50
23
136
(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection
7
13
5.75
2.93
3.4
1.9
—
—
—
0
0
(3013512) EKG study
30
168
2.19
2.84
4.1
3.3
—
—
—
0
0
(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection
7
14
5.33
2.79
3.4
2.0
—
—
—
0
0
(3019225) pH of Specimen
12
43
3.07
2.77
16.5
4.0
—
—
—
0
0
(3024928) Oxygen saturation in Venous blood
6
10
6.34
2.74
1.8
17.2
—
—
—
0
0
(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence
6
10
6.34
2.74
1.7
1.0
—
—
—
0
0
(3004119) Hemoglobin [Mass/volume] in Venous blood
10
32
3.40
2.74
6.1
9.3
g/l
118.1
130.4
—
10
32
(3027273) Bicarbonate [Moles/volume] in Venous blood
9
25
3.89
2.66
7.9
5.5
mmol/l
23.2
24.6
—
9
25
(3000494) Fungus identified in Specimen by Culture
18
83
2.47
2.63
2.1
1.7
—
—
—
0
0
(36305247) Microscopic observation [Identifier] in Isolate by Gram stain
7
16
4.65
2.53
1.1
1.4
—
—
—
0
0
(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection
5
8
6.54
2.40
1.0
1.0
—
—
—
0
0
(3019060) Gas panel - Arterial blood
10
35
3.10
2.39
11.7
17.5
—
—
—
0
0
(3006217) Methemoglobin/Hemoglobin.total in Arterial blood
11
41
2.92
2.38
10.2
7.6
%
0.8
0.8
0.00
11
41
(40760892) CBC W Ordered Manual Differential panel - Blood
31
187
2.02
2.37
8.4
4.8
—
—
—
0
0
(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection
8
23
3.72
2.33
3.1
2.0
—
—
—
0
0
(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma
28
164
2.04
2.31
3.1
1.8
mg/l
1.3
1.1
0.09
23
125
(3052851) Hemolysis interference index of Serum or Plasma
6
13
4.87
2.31
2.8
3.0
—
—
—
0
0
(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood
11
42
2.85
2.28
10.2
7.5
%
1.4
1.7
0.33
11
42
(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection
8
24
3.56
2.24
3.9
2.3
—
—
—
0
0
(3042936) Bacteria identified in Isolate by Culture
18
90
2.26
2.20
3.1
2.4
—
—
—
0
0
(36660697) Celiac disease serology panel - Serum
15
69
2.42
2.19
1.5
1.2
—
—
—
0
0
(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection
6
14
4.51
2.19
4.0
1.9
—
—
—
0
0
(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum
6
14
4.51
2.19
1.2
7.4
—
—
—
0
0
(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection
15
70
2.38
2.13
3.0
1.7
—
—
—
0
0
(40758558) Short blood count panel - Blood
29
177
1.95
2.12
5.3
8.3
—
—
—
0
0
(3019550) Sodium [Moles/volume] in Serum or Plasma
81
713
2.71
2.08
46.3
13.9
mmol/l
139.2
139.6
0.79
81
695
(3014007) Fractional oxyhemoglobin in Arterial blood
10
39
2.76
2.00
11.0
7.9
%
93.6
93.7
—
10
39
(3022313) Gas panel - Capillary blood
9
33
2.92
1.99
19.1
3.2
—
—
—
0
0
(3001079) Blood group antibody screen [Presence] in Serum or Plasma
44
314
1.80
1.95
5.3
4.6
—
—
—
0
0
(3023103) Potassium [Moles/volume] in Serum or Plasma
81
716
2.65
1.92
46.6
14.0
mmol/l
3.9
3.9
0.09
81
698
(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection
14
67
2.30
1.88
3.1
1.6
—
—
—
0
0
(3037467) Urinalysis macro (dipstick) panel - Urine
61
485
1.84
1.84
7.9
4.4
—
—
—
0
0
(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay
7
23
3.21
1.84
3.4
2.7
g/l
4.0
3.8
—
7
23
(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma
36
247
1.77
1.79
3.4
2.8
u/l
37.0
30.4
0.57
36
236
(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection
6
18
3.50
1.78
4.0
1.8
—
—
—
0
0
(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection
6
18
3.50
1.78
4.0
1.8
—
—
—
0
0
(3009445) Proteinase 3 Ab [Units/volume] in Serum
8
30
2.83
1.77
1.6
1.7
—
—
—
0
0
(4035726)
11
50
2.37
1.65
2.2
1.2
—
—
—
0
0
(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip
39
282
1.69
1.57
6.7
3.7
—
—
—
0
0
(3050449) Albumin [Mass/time] in Urine collected for unspecified duration
5
15
3.47
1.54
3.8
2.6
ug/min
23.4
27.5
—
5
8
(3037121) Protein [Mass/volume] in Urine
6
21
2.99
1.53
10.5
3.9
g/l
0.6
0.1
—
6
8
(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection
9
37
2.59
1.53
1.6
1.2
—
—
—
0
0
(3021601) Nitrite [Presence] in Urine by Test strip
46
352
1.64
1.47
7.7
5.2
estimate
0.0
0.0
0.00
19
72
(3020891) Body temperature
6
22
2.85
1.46
12.5
3.1
—
—
—
0
0
(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence
5
16
3.25
1.46
2.0
1.8
—
—
—
0
0
(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum
5
16
3.25
1.46
2.0
1.1
—
—
—
0
0
(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection
5
17
3.05
1.38
2.6
2.6
—
—
—
0
0
(3009261) Glucose [Presence] in Urine by Test strip
46
356
1.61
1.37
6.4
3.9
estimate
0.0
0.0
0.49
17
69
(3035350) Ketones [Presence] in Urine by Test strip
46
356
1.61
1.37
6.3
3.7
estimate
0.0
0.0
0.00
20
74
(3041096) Erythrocytes [Presence] in Urine by Automated
30
210
1.65
1.33
5.6
3.1
—
—
—
0
0
(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma
6
24
2.61
1.33
3.5
1.3
nmol/l
52.7
32.9
—
6
24
(3025941) Bacteria identified in Stool by Culture
10
49
2.17
1.27
1.5
1.1
—
—
—
0
0
(3044640) Blood type and Crossmatch panel - Blood
30
214
1.61
1.23
3.7
2.2
—
—
—
0
0
(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay
6
26
2.40
1.21
1.2
1.1
—
—
—
0
0
(40762366) Oxygen capacity [Volume Fraction] in Arterial blood
7
33
2.22
1.08
10.3
24.8
—
—
—
0
0
(3009542) Hematocrit [Volume Fraction] of Blood
61
686
0.64
1.06
28.0
13.9
%
38.4
40.4
1.02
41
542
(3013139) Helicobacter pylori Ag [Presence] in Stool
7
34
2.15
1.05
1.1
1.1
—
—
—
0
0
(46236098) ABO and Rh group [Type] in Blood by Confirmatory method
22
151
1.61
1.04
3.7
2.2
—
—
—
0
0
(3044889) 12 lead EKG panel
54
455
1.48
0.98
5.3
3.4
—
—
—
0
0
(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma
17
113
1.63
0.90
4.2
4.4
ug/l
1.0
1.9
2.09
17
101
(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection
6
31
2.00
0.86
1.5
1.6
—
—
—
0
0
(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count
16
108
1.59
0.80
2.8
2.7
e6/l
0.1
1.1
3.64
11
62
(40761535) Cells panel - Urine sediment
9
53
1.78
0.78
6.3
3.9
—
—
—
0
0
(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay
5
23
2.24
0.77
1.2
1.3
—
—
—
0
0
(3007930) Methemoglobin/Hemoglobin.total in Blood
5
23
2.24
0.77
10.2
28.4
%
0.5
0.9
—
5
23
(3022145) Colonoscopy Study observation
12
76
1.67
0.76
1.3
1.3
—
—
—
0
0
(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay
5
24
2.15
0.76
9.0
2.8
%
233.8
198.4
—
5
24
(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay
5
25
2.06
0.74
2.0
2.2
—
—
—
0
0
(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count
15
102
1.57
0.73
3.1
2.9
e6/l
1.1
4.9
—
10
56
(3045414) Leukocytes [Presence] in Urine
5
27
1.90
0.69
2.4
2.0
—
—
—
0
0
(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection
9
139
0.61
0.67
2.0
2.4
—
—
—
0
0
(21494755) Public health laboratory ask at order entry panel
6
101
0.56
0.67
1.2
1.3
—
—
—
0
0
(3000492) Spirometry study
10
63
1.66
0.65
1.7
1.4
—
—
—
0
0
(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma
12
80
1.58
0.63
2.6
2.4
umol/l
6.3
4.3
0.67
12
71
(3002385) Erythrocyte distribution width [Ratio]
69
632
1.43
0.63
33.7
15.6
%
14.2
13.5
2.19
69
626
(3023351) European house dust mite IgE Ab [Units/volume] in Serum
0
20
0.00
0.61
0.0
1.1
—
1.9
—
0
8
(3023511) Choriogonadotropin [Units/volume] in Urine
0
23
0.00
0.59
0.0
1.3
—
—
—
0
0
(3030981) Hyaline casts [#/volume] in Urine by Automated count
6
39
1.58
0.54
3.2
1.9
e6/l
0.0
0.0
—
6
39
(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal
7
47
1.53
0.49
1.1
1.0
—
—
—
0
0
(3017143) Hepatitis C virus Ab [Presence] in Serum
15
112
1.41
0.48
1.9
1.5
—
—
—
0
0
(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection
9
127
0.68
0.47
1.8
2.2
—
—
—
0
0
(3015736) pH of Urine
33
281
1.28
0.46
5.2
3.5
—
—
—
0
0
(3000330) Specific gravity of Urine by Test strip
5
31
1.65
0.44
3.8
4.2
—
—
—
0
0
(3014133) Dog dander IgE Ab [Units/volume] in Serum
0
15
0.00
0.41
0.0
1.0
—
2.0
—
0
7
(3010726) Horse dander IgE Ab [Units/volume] in Serum
0
15
0.00
0.41
0.0
1.0
—
3.2
—
0
5
(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
(3048929) Epstein Barr virus Ab [Presence] in Serum
5
34
1.50
0.41
1.4
1.4
—
—
—
0
0
(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture
14
179
0.74
0.40
2.1
1.6
—
—
—
0
0
(3003740) Influenza virus B Ag [Presence] in Specimen
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
(3002523) Influenza virus A Ag [Presence] in Specimen
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
(3011397) Hemoglobin [Presence] in Urine by Test strip
20
162
1.30
0.40
6.1
4.0
—
—
—
0
0
(3020460) C reactive protein [Mass/volume] in Serum or Plasma
76
724
1.36
0.38
33.6
12.8
mg/l
16.6
20.8
0.97
68
547
(1761868) Lipid panel - Serum or Plasma
23
270
0.80
0.35
4.8
2.6
—
—
—
0
0
(3022621) pH of Urine by Test strip
6
45
1.36
0.34
3.2
2.8
—
—
—
0
0
(3019284) Hepatitis B virus surface Ag [Presence] in Serum
20
167
1.26
0.32
2.1
1.7
—
—
—
0
0
(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep
18
149
1.26
0.31
1.9
1.5
—
—
—
0
0
(40768804) Tissue Pathology biopsy report
32
283
1.21
0.31
2.4
1.9
—
—
—
0
0
(3035941) MCH [Entitic mass]
81
825
0.77
0.31
48.3
18.7
pg
30.1
30.1
0.02
81
818
(3000963) Hemoglobin [Mass/volume] in Blood
81
825
0.77
0.31
49.1
18.9
g/l
129.0
136.4
4.74
81
817
(3024731) MCV [Entitic volume]
81
825
0.77
0.31
48.4
18.8
fl
90.9
90.1
0.93
81
818
(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum
16
131
1.27
0.30
1.4
1.3
u/ml
1.2
8.0
—
6
66
(3021879) Hepatitis B virus core Ab [Presence] in Serum
8
66
1.23
0.27
1.4
1.5
—
—
—
0
0
(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma
69
717
0.83
0.24
8.0
4.3
mmol/l
2.5
2.8
1.84
63
667
(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection
59
560
1.16
0.22
3.6
3.6
—
—
—
0
0
(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
(3000081) cloZAPine [Moles/volume] in Serum or Plasma
0
12
0.00
0.21
0.0
13.9
—
1216.1
—
0
12
(3023430) Cat dander IgE Ab [Units/volume] in Serum
0
12
0.00
0.21
0.0
1.0
—
1.8
—
0
6
(3008832) Norclozapine [Moles/volume] in Serum or Plasma
0
12
0.00
0.21
0.0
10.2
—
685.7
—
0
12
(3016701) Glucose [Moles/volume] in Serum or Plasma --2 hours post dose glucose
0
14
0.00
0.20
0.0
1.2
—
7.5
—
0
7
(3008401) Mugwort IgE Ab [Units/volume] in Serum
0
14
0.00
0.20
0.0
1.0
—
0.1
—
0
6
(3002256) Pathology report gross observation
9
80
1.14
0.16
1.2
1.2
—
—
—
0
0
(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma
10
84
1.21
0.14
23.8
8.1
—
—
—
0
0
(40761511) CBC panel - Blood by Automated count
78
765
1.17
0.11
34.8
11.6
—
—
—
0
0
(3019900) Cholesterol [Moles/volume] in Serum or Plasma
69
706
0.90
0.10
7.6
3.9
mmol/l
4.5
4.7
0.96
64
661
(4010399)
5
44
1.14
0.10
1.2
1.3
—
—
—
0
0
(3019832) Treponema pallidum Ab [Presence] in Serum
11
124
0.87
0.10
1.8
1.9
—
—
—
0
0
(46235355) HIV 1 and 2 tests - Meaningful Use set
19
205
0.91
0.09
2.2
2.1
—
—
—
0
0
(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma
69
703
0.91
0.07
7.3
3.9
mmol/l
1.6
1.5
0.97
64
657
(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting
67
673
0.98
0.00
6.6
3.6
mmol/l
1.2
1.2
0.21
62
626
(3003694) ABO and Rh group [Type] in Blood
21
213
0.98
0.00
1.9
1.6
—
—
—
0
0
(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(40761995) Spermatozoa Progressive [#/volume] in Semen
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3019897) Erythrocyte distribution width [Ratio] by Automated count
0
6
0.00
0.00
0.0
1.5
—
13.5
—
0
6
(40768800) Prostate Pathology biopsy report
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3047189) Immunofixation for 24 hour Urine
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
(3005570) Glucose [Moles/volume] in Urine
0
9
0.00
0.00
0.0
3.9
—
—
—
0
0
(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count
0
7
0.00
0.00
0.0
4.9
—
—
—
0
0
(3017315) Amylase [Enzymatic activity/volume] in Urine
0
5
0.00
0.00
0.0
1.0
—
141.2
—
0
5
(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum
0
5
0.00
0.00
0.0
1.0
—
10.0
—
0
5
(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3014043) Spermatozoa Nonprogressive/100 spermatozoa in Semen
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(4198724)
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.3
—
1.0
—
0
6
(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.6
—
5.1
—
0
5
(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma
0
6
0.00
0.00
0.0
1.0
—
109.7
—
0
6
(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
0.3
—
0
5
(4211845)
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay
0
8
0.00
0.00
0.0
4.0
—
138.7
—
0
8
(3016724) Homocysteine [Moles/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.2
—
18.4
—
0
5
(4281824)
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
(3022756) Ceruloplasmin [Mass/volume] in Serum or Plasma
0
5
0.00
0.00
0.0
1.0
—
282.2
—
0
5
(1617658) Protocol used for examination of sentinel lymph nodes
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_DYSPOLYGL and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have E4_DYSPOLYGL.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: E4_DYSPOLYGL – Polyglandular dysfunction
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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