Autoimmune polyglandular failure

E4_AUTOPOLYFAI

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E31.00, E31.01, E31.08 Hospital discharge: ICD-9 — 2581 Cause of death: ICD-10 — E31.00, E31.01, E31.08 Cause of death: ICD-9 — 2581 2 out of 7 registries used, show all original rules.	52
4. Check minimum number of events None	52
5. Include endpoints None	52
6. Filter based on genotype QC (FinnGen only)	52

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	E4_AUTOPOLYFAI
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E310
HD_ICD_9	2581
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E310
COD_ICD_9	2581
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Autoimmune polyglandular failure based on the number of shared cases.

Similar with more cases:

Similar with less cases:

APECED

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	302	189	110
Only index persons	247	161	86
Unadjusted period prevalence (%)
Whole population	0.00	0.01	0.00
Only index persons	0.01	0.01	0.00
Median age at first event (years)
Whole population	33.80	36.67	28.51
Only index persons	31.59	35.00	25.22

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	52	31	21
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	25.90	32.76	15.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018418) pH of Serum or Plasma

9.69

14.93

29.8

3.4

7.4

0.57

(3023368) Bacteria identified in Blood by Culture

7.55

12.28

7.1

4.6

—

(3012516) Albumin [Mass/volume] in Urine

7.35

11.86

6.5

3.1

44.3

47.0

mg/l

0.05

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

126

7.71

11.55

4.2

1.7

98.5

97.7

pmol/l

0.03

(3020682) Albumin/Creatinine [Ratio] in Urine

101

7.21

11.52

8.5

3.8

10.0

9.0

mg/mmol

0.07

(3021447) Carbon dioxide [Partial pressure] in Venous blood

9.60

11.28

7.7

11.7

5.9

5.7

kpa

0.30

(3012544) pH of Venous blood

9.19

10.88

6.1

12.1

—

(3000991) Gas panel - Venous blood

9.18

10.34

9.8

11.5

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

143

7.16

10.33

11.3

5.1

34.7

36.7

g/l

2.01

137

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

151

7.33

10.25

37.9

9.4

1.1

1.2

mmol/l

3.06

138

(1616796) Gas panel - Central venous blood

28.12

9.93

8.3

1.3

—

(3032080) INR in Blood by Coagulation assay

123

6.10

9.43

9.8

6.9

1.2

inr

0.03

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

8.34

9.04

12.6

11.5

25.4

24.9

mmol/l

0.09

(3010838) Calcium [Moles/time] in 24 hour Urine

+∞

8.56

2.4

0.0

—

(40768797) Stomach Pathology biopsy report

6.01

8.46

1.4

1.2

—

(3021440) Promyelocytes/100 leukocytes in Blood

7.29

8.03

5.5

2.4

0.1

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

109

5.14

7.97

6.7

3.6

2.2

2.3

mmol/l

1.77

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

111

5.02

7.74

2.0

1.5

0.8

1.3

u/ml

—

(3000494) Fungus identified in Specimen by Culture

5.67

7.20

2.1

1.9

—

(3017181) Myelocytes/100 leukocytes in Blood

6.47

7.17

5.6

2.3

1.4

0.6

—

(3027315) Oxygen [Partial pressure] in Blood

15.06

6.95

10.5

1.4

9.3

9.6

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

15.06

6.95

10.5

1.4

5.0

4.9

kpa

—

(3007164) IgA [Mass/volume] in Serum or Plasma

106

4.56

6.84

1.9

1.4

2.6

2.3

g/l

0.41

(3003181) Sodium [Moles/volume] in Urine

17.24

6.71

1.3

82.6

67.3

mmol/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.97

6.63

3.5

1.7

—

(3021960) Folate [Moles/volume] in Serum or Plasma

4.56

6.55

2.6

1.3

17.8

19.6

nmol/l

0.26

(3028271) Lactate [Moles/volume] in Capillary blood

21.28

6.52

3.0

1.6

2.0

1.3

mmol/l

—

(3012565) Volume of 24 hour Urine

+∞

6.37

3.0

0.0

3293.3

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

6.71

6.10

1.6

1.1

—

(3025159) Blasts/100 leukocytes in Blood

6.20

6.08

6.1

2.5

0.0

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

233

5.17

5.81

13.8

7.0

8.8

6.6

mmol/l

3.22

217

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

122

3.81

5.34

8.3

2.4

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

15.84

4.72

11.3

1.0

59.1

64.2

—

(3022806) Fractional oxyhemoglobin in Capillary blood

15.84

4.72

2.6

1.4

92.4

91.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

4.62

4.71

3.9

1.7

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

10.23

4.45

8.1

8.6

24.0

23.3

mmol/l

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

13.19

4.41

3.4

1.2

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

13.19

4.41

3.4

1.3

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

4.58

4.37

4.4

3.3

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

9.20

4.23

8.9

4.6

66.7

64.4

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.23

4.22

2.8

1.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

141

3.14

3.96

4.3

3.0

20.8

20.7

ng/l

0.00

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

9.87

3.90

3.4

1.3

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

9.87

3.90

3.4

1.3

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

13.30

3.86

10.2

1.0

4.2

5.7

e9/l

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

13.30

3.86

1.5

2.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

4.03

3.74

2.9

1.5

—

(42870588) Differential panel, method unspecified - Blood

130

3.00

3.66

11.1

6.7

—

(3021901) Oxygen saturation in Capillary blood

11.07

3.59

3.3

1.2

—

(36304419) Bacteria [Presence] in Urine

3.07

3.57

7.2

2.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

5.80

3.55

1.7

—

(3002582) Erythrocytes [#/volume] in Urine

102

3.01

3.51

7.3

2.4

39.2

643.4

e6/l

0.47

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

6.53

3.49

6.4

12.4

1.8

1.1

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

6.53

3.49

7.4

17.4

119.7

125.9

g/l

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

9.48

3.35

4.0

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

9.48

3.35

4.0

1.3

—

(3019225) pH of Specimen

4.95

3.16

12.1

3.4

—

(3004588) Protein electrophoresis panel - Serum or Plasma

8.28

3.14

1.5

4.6

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

8.28

3.14

1.7

1.0

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

6.55

3.13

2.3

1.7

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

3.89

3.08

1.6

2.7

229.1

241.6

u/l

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

3.89

3.08

13.7

25.3

118.1

129.8

g/l

—

(3014007) Fractional oxyhemoglobin in Arterial blood

5.05

2.93

12.4

12.6

93.6

91.8

—

(40758558) Short blood count panel - Blood

2.73

2.86

3.3

7.4

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

9.04

2.81

1.0

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

145

2.59

2.81

3.4

3.0

42.9

32.7

u/l

0.66

140

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

4.53

2.69

12.4

11.3

0.6

0.8

—

(3024928) Oxygen saturation in Venous blood

7.74

2.60

2.0

24.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

7.74

2.60

1.4

1.0

—

(3019060) Gas panel - Arterial blood

4.30

2.58

14.1

26.3

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

4.30

2.58

12.4

10.9

1.5

1.8

—

(3013512) EKG study

2.61

2.58

4.5

3.0

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

5.49

2.47

2.3

191.7

143.6

ng/l

—

(3018405) Lactate [Moles/volume] in Arterial blood

5.49

2.47

11.8

1.8

1.4

1.8

mmol/l

—

(3018095) Leukocytes [#/volume] in Urine

127

2.45

2.47

7.5

3.1

17.6

31.5

e6/l

0.32

(40760892) CBC W Ordered Manual Differential panel - Blood

113

2.44

2.37

10.4

3.3

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

5.06

2.34

1.8

1.2

1.5

0.2

ug/l

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

4.09

2.24

20.7

3.6

25.5

25.8

mmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

117

2.33

2.16

3.2

2.3

—

(40761535) Cells panel - Urine sediment

3.31

2.03

6.1

3.4

—

(40761536) Microorganisms panel - Urine sediment

2.86

1.97

10.5

3.1

—

(3026008) Bacteria identified in Urine by Culture

105

2.28

1.97

4.8

2.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.37

1.96

3.2

2.4

—

(3022145) Colonoscopy Study observation

2.70

1.93

1.4

1.2

—

(36660697) Celiac disease serology panel - Serum

2.78

1.88

1.7

1.3

—

(3020891) Body temperature

4.48

1.87

14.6

1.9

—

(3025941) Bacteria identified in Stool by Culture

3.20

1.79

1.7

1.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

4.13

1.75

1.2

1.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.13

1.75

2.8

1.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

4.13

1.75

4.0

2.0

—

(3042936) Bacteria identified in Isolate by Culture

2.52

1.71

4.3

3.1

—

(3029937) Albumin [Presence] in Urine by Test strip

119

2.11

1.70

7.1

3.3

0.0

estimate

0.00

(3022313) Gas panel - Capillary blood

3.25

1.63

23.7

3.3

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

3.57

1.56

4.0

1.3

52.8

33.1

nmol/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

175

1.97

1.56

4.1

5.0

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.34

1.47

3.8

1.7

79.2

89.1

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

3.14

1.39

1.6

1.7

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

1.21

0.0

1.5

—

(3037467) Urinalysis macro (dipstick) panel - Urine

290

1.78

1.07

7.7

4.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.40

1.06

1.2

1.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.83

1.00

1.8

1.5

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.29

0.95

1.2

1.0

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.88

0.82

2.3

2.5

6.0

4.4

umol/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

213

1.56

0.78

8.1

4.5

0.0

estimate

0.00

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.48

0.75

1.4

2.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.68

0.75

4.9

3.7

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

177

1.54

0.73

7.0

3.1

—

(3009261) Glucose [Presence] in Urine by Test strip

216

1.52

0.71

7.0

3.3

0.0

0.1

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

216

1.52

0.71

7.0

3.2

0.0

estimate

0.00

(4035726)

1.80

0.65

2.0

1.1

—

(3015736) pH of Urine

172

1.48

0.63

5.6

3.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.54

0.63

1.2

2.2

—

(3005033) Fetal Nuchal fold Thickness US

0.00

0.62

0.0

1.3

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.62

0.0

1.3

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.61

0.0

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.61

0.0

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.61

0.0

1.3

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.61

0.0

1.5

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.61

0.0

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.61

0.0

1.3

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

0.00

0.60

0.0

1.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.58

0.58

5.2

4.3

0.9

1.9

ug/l

1.53

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.58

0.58

1.3

0.9

2.1

u/ml

—

(3000492) Spirometry study

1.70

0.58

1.8

1.2

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.49

0.48

24.0

6.7

—

(1761868) Lipid panel - Serum or Plasma

178

0.71

0.44

6.0

2.6

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.42

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.42

0.0

1.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

0.00

0.41

0.0

1.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

124

0.67

0.41

1.8

2.1

—

(3041096) Erythrocytes [Presence] in Urine by Automated

136

1.37

0.40

7.1

2.6

—

(3044889) 12 lead EKG panel

274

1.33

0.38

5.8

3.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

106

0.71

0.33

1.4

1.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

417

0.74

0.32

27.6

14.4

38.7

41.2

2.20

342

(40768804) Tissue Pathology biopsy report

164

1.25

0.25

2.2

1.8

—

(3003694) ABO and Rh group [Type] in Blood

114

0.75

0.23

1.6

1.7

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.21

0.0

1.0

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

3.2

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.21

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.20

0.0

1.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.20

0.0

1.4

—

(3023351) European house dust mite IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

349

1.21

0.18

3.6

3.7

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.70

0.18

1.6

2.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.22

0.14

1.7

—

(3002256) Pathology report gross observation

1.12

0.10

1.0

1.1

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.0

—

(40758310) Human epididymis protein 4 [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

35.4

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

0.0

3.6

—

0.7

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

12.1

—

1219.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.0

1.0

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

9.9

—

712.9

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

102.6

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.4

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

0.9

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

0.0

1.2

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.0

1.0

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.00

0.00

1.7

1.5

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_AUTOPOLYFAI and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_AUTOPOLYFAI.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_AUTOPOLYFAI – Autoimmune polyglandular failure

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Autoimmune polyglandular failure

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints