Coalworker pneumoconiosis

J10_COALPNEUMOC

anthracosis: A diffuse parenchymal lung disease caused by accumulation of inhaled CARBON or coal dust. The disease can progress from asymptomatic anthracosis to massive lung fibrosis. This lung lesion usually occurs in coal MINERS, but can be seen in urban dwellers and tobacco smokers.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — J60 Hospital discharge: ICD-9 — 500 Cause of death: ICD-10 — J60 Cause of death: ICD-9 — 500 2 out of 7 registries used, show all original rules.	25
4. Check minimum number of events None	25
5. Include endpoints None	25
6. Filter based on genotype QC (FinnGen only)	25

Control definitions (FinnGen only)

Control exclude: J10_EXTERLUNG

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: J60-J70
Name in latin: Anthracosis pulmonum

NAME	J10_COALPNEUMOC
CONTROL_EXCLUDE	J10_EXTERLUNG
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	J60
HD_ICD_9	500
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	J60
COD_ICD_9	500
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Coalworker pneumoconiosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	237	70	160
Only index persons	147	47	100
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	66.66	62.39	68.05
Only index persons	57.89	56.57	58.52

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	25	9	16
Unadjusted period prevalence (%)	0.01	0.00	0.01
Median age at first event (years)	62.94	56.57	66.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

4.00

2.06

1.7

2.6

—

(3020630) Protein [Mass/volume] in Serum or Plasma

3.89

1.60

1.8

2.5

60.2

66.8

g/l

—

(3012544) pH of Venous blood

3.89

1.60

2.2

2.0

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

3.89

1.60

1.8

2.0

6.3

5.1

kpa

—

(3003694) ABO and Rh group [Type] in Blood

0.00

1.49

0.0

1.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.02

1.28

3.0

1.3

—

(36304419) Bacteria [Presence] in Urine

2.36

1.17

2.6

2.5

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.71

1.15

3.0

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

2.23

1.04

2.1

1.4

1202.3

1236.0

nmol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

124

2.15

1.02

6.3

5.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.06

0.87

2.3

2.7

—

(3026008) Bacteria identified in Urine by Culture

1.90

0.83

4.0

3.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.92

0.76

3.1

5.7

—

(3023368) Bacteria identified in Blood by Culture

1.88

0.71

3.9

—

(42870588) Differential panel, method unspecified - Blood

1.79

0.68

11.5

5.1

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.00

0.64

1.8

2.7

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.00

0.63

0.0

5.2

—

12.6

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

1.73

0.56

13.6

10.4

4.4

4.0

e9/l

0.25

(3015736) pH of Urine

1.75

0.55

3.8

4.7

—

(3013512) EKG study

1.56

0.48

5.5

3.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.83

0.47

3.0

2.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.00

0.43

0.0

1.8

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.43

0.0

2.9

—

0.1

—

(3044640) Blood type and Crossmatch panel - Blood

1.55

0.36

2.1

2.4

—

(40758558) Short blood count panel - Blood

1.39

0.25

5.6

6.9

—

(3022621) pH of Urine by Test strip

0.00

0.22

0.0

4.0

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.22

0.0

1.1

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.21

0.0

2.5

—

1.1

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.21

0.0

1.2

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

0.00

0.21

0.0

3.9

—

1.5

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

0.00

0.21

0.0

2.0

—

66.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.75

0.19

5.3

4.8

—

(3031040) Bacteria [#/volume] in Urine by Automated count

125

1.27

0.14

5.0

5.5

—

1223.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

136

1.26

0.13

21.9

15.5

41.0

39.5

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

112

0.82

0.10

4.5

4.4

6.0

6.5

mmol/l

—

104

(3035941) MCH [Entitic mass]

185

0.90

0.09

31.6

23.0

30.5

30.4

0.03

180

(3000963) Hemoglobin [Mass/volume] in Blood

185

0.90

0.09

31.8

23.1

131.1

135.1

g/l

0.44

180

(3010813) Leukocytes [#/volume] in Blood

185

0.90

0.09

31.7

23.1

6.6

e9/l

0.01

177

(3026361) Erythrocytes [#/volume] in Blood

185

0.90

0.09

31.7

23.1

4.3

4.5

e12/l

0.38

177

(3007461) Platelets [#/volume] in Blood

185

0.90

0.09

31.6

23.1

253.2

238.6

e9/l

0.42

178

(3024731) MCV [Entitic volume]

184

0.92

0.09

31.6

23.1

92.7

91.6

0.45

179

(3020564) Creatinine [Moles/volume] in Serum or Plasma

178

0.86

0.09

26.3

18.7

82.1

80.4

umol/l

0.14

178

(40761511) CBC panel - Blood by Automated count

170

1.21

0.08

18.1

15.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

0.87

0.08

2.5

3.7

—

(3002385) Erythrocyte distribution width [Ratio]

132

1.14

0.03

27.4

18.2

14.1

13.9

0.32

126

(3044889) 12 lead EKG panel

117

1.05

0.00

4.5

3.9

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

0.91

0.00

3.3

4.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

171

0.98

0.00

25.2

18.4

139.8

139.4

mmol/l

0.18

166

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.0

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

4.5

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.8

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.6

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.1

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.3

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.6

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.0

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

0.00

0.0

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.4

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.0

—

(3040151) Glucose [Moles/volume] in Capillary blood

0.00

0.0

5.0

—

7.0

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

178

1.04

0.00

15.4

10.6

24.0

24.3

u/l

0.03

172

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

172

0.96

0.00

25.3

18.2

4.0

mmol/l

0.01

167

(4094501)

0.00

0.0

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.0

—

(1002224) Polysomnography panel

0.00

0.0

1.1

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

1.2

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.0

1.9

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.0

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint J10_COALPNEUMOC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have J10_COALPNEUMOC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: J10_COALPNEUMOC – Coalworker pneumoconiosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Coalworker pneumoconiosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints