This is a non-core endpoint: only basic statistics are computed.

Chondrolysis

M13_CHONDROLYSIS

cartilage disease: Softening and degeneration of the CARTILAGE. Pathological processes involving the chondral tissue (CARTILAGE).

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M94.3 Cause of death: ICD-10 — M94.3 2 out of 7 registries used, show all original rules.	17
4. Check minimum number of events None	17
5. Include endpoints None	17
6. Filter based on genotype QC (FinnGen only)	17

Control definitions (FinnGen only)

Control exclude: M13_OTHERBONE

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M94
Name in latin: Chondrolysis

NAME	M13_CHONDROLYSIS
CONTROL_EXCLUDE	M13_OTHERBONE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M943
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M943
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Chondrolysis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	116	63	53
Only index persons	112	62	50
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	44.43	42.41
Only index persons	42.97	43.70	42.07

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	17	14	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	43.11	44.95	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3002256) Pathology report gross observation

3.83

1.68

1.3

1.1

—

(3015736) pH of Urine

2.68

1.24

3.9

2.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.59

1.13

2.4

2.5

—

(42870588) Differential panel, method unspecified - Blood

2.69

1.10

2.4

6.0

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

2.28

0.94

2.2

8.6

mmol/l

1.2

—

(3006504) Eosinophils/100 leukocytes in Blood

2.41

0.94

3.0

6.5

3.3

3.0

—

(3018010) Neutrophils/100 leukocytes in Blood

2.35

0.93

3.0

6.0

50.8

53.8

—

(3002030) Lymphocytes/100 leukocytes in Blood

2.19

0.88

3.0

6.2

30.5

30.8

—

(3022145) Colonoscopy Study observation

0.00

0.87

0.0

1.1

—

(3018418) pH of Serum or Plasma

2.17

0.68

1.5

3.4

—

7.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

1.80

0.54

3.6

2.9

—

(3037467) Urinalysis macro (dipstick) panel - Urine

1.98

0.51

4.3

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.43

0.0

1.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.60

0.43

1.0

1.6

—

(3013512) EKG study

1.66

0.42

2.3

2.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.51

0.39

2.3

2.8

—

(3005719) IgG [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

1.9

—

9.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.31

0.22

3.1

4.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.22

0.0

1.3

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.22

0.0

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.8

—

(3027008) Opiates [Presence] in Urine

0.00

0.22

0.0

1.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.22

0.0

1.8

—

(3016879) Cocaine [Presence] in Urine

0.00

0.22

0.0

1.3

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.00

0.22

0.0

4.7

—

104.6

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.22

0.0

1.4

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.00

0.22

0.0

2.6

—

0.7

—

(40768804) Tissue Pathology biopsy report

1.36

0.22

2.0

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

4.1

—

2.0

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

0.00

0.21

0.0

1.8

—

28.8

—

(3044889) 12 lead EKG panel

107

0.84

0.10

3.1

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

1.18

0.10

2.1

3.6

mmol/l

7.1

6.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.0

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.00

0.0

2.9

—

(3028026) IgM [Mass/volume] in Serum or Plasma

0.00

0.0

1.7

—

1.4

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.0

—

(3024354) Oxygen [Partial pressure] in Venous blood

0.00

0.0

1.8

—

5.0

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.0

—

1.5

—

(3020044) Glucose [Moles/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

3.4

—

(3027475) Erythrocytes [#/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

793.7

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

1.5

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

1.2

—

12.1

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.3

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.0

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

0.00

0.0

8.0

—

5.8

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.0

1.1

—

(3023520) Reticulocytes [#/volume] in Blood

0.00

0.0

6.3

—

77.3

—

(4094501)

0.00

0.0

1.0

—

(3027945) Reticulocytes/100 erythrocytes in Blood

0.00

0.0

5.3

—

1.8

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.0

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

1.0

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(40758558) Short blood count panel - Blood

1.03

0.00

2.2

5.9

—

(3004809) Band form neutrophils/100 leukocytes in Blood

0.00

0.0

3.2

—

4.6

—

(3012544) pH of Venous blood

0.00

0.0

6.4

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.4

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

0.00

0.0

2.2

—

24.8

—

(3000991) Gas panel - Venous blood

0.00

0.0

2.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.3

—

(3019473) Protein [Mass/volume] in Cerebral spinal fluid

0.00

0.0

1.0

—

401.0

—

(1761868) Lipid panel - Serum or Plasma

1.05

0.00

2.0

2.4

—

(3046279) Procalcitonin [Mass/volume] in Serum or Plasma

0.00

0.0

2.4

—

0.6

—

(3011985) Renin [Units/volume] in Plasma

0.00

0.0

1.0

—

26.1

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

2.6

—

119.4

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_CHONDROLYSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_CHONDROLYSIS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: M13_CHONDROLYSIS – Chondrolysis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Chondrolysis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints