This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Drug-induced nonautoimmune haemolytic anaemia

Endpoint Browser

D3_NONAIHA_DRUG

No definition available.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D59.2# Cause of death: ICD-10 — D59.2# 2 out of 7 registries used, show all original rules.	16
4. Check minimum number of events None	16
5. Include endpoints None	16
6. Filter based on genotype QC (FinnGen only)	16

Control definitions (FinnGen only)

Control exclude: D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D59
Name in latin: Anaemia non autoimmunis haemolytica e medicamentis

NAME	D3_NONAIHA_DRUG
CONTROL_EXCLUDE	D3_HAEMOLYTICANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D592
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D592
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Drug-induced nonautoimmune haemolytic anaemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	103	50	52
Only index persons	82	44	38
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	64.93	66.48	64.16
Only index persons	63.10	66.48	59.19

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	16	8	8
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	62.67	52.09	73.25

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

+∞

7.91

3.1

0.0

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

16.82

5.46

9.6

1.8

396.11

250.55

u/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

16.19

4.97

1.1

1.3

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

11.28

4.47

6.4

3.1

0.94

0.90

mmol/l

—

(3027945) Reticulocytes/100 erythrocytes in Blood

11.01

4.12

5.5

1.2

1.89

1.78

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

10.17

3.95

1.0

1.4

—

(40758558) Short blood count panel - Blood

6.09

3.03

16.4

6.6

—

(3023368) Bacteria identified in Blood by Culture

6.11

3.02

7.4

4.6

—

(36304419) Bacteria [Presence] in Urine

5.88

2.93

2.5

2.9

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

6.04

2.61

1.7

1.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

8.43

2.57

1.6

1.0

—

(3044640) Blood type and Crossmatch panel - Blood

4.71

2.37

6.2

2.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

5.08

2.29

1.1

1.6

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

5.71

2.29

1.8

1.2

—

(3026782) Osmolality of Urine

4.66

2.26

2.3

2.7

466.38

569.35

mosm/kgh2o

—

(3026008) Bacteria identified in Urine by Culture

4.23

2.14

2.2

2.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.36

2.01

2.0

1.4

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

4.15

1.78

1.7

1.9

32.83

30.81

—

(3042936) Bacteria identified in Isolate by Culture

4.34

1.66

2.2

2.9

—

(3003694) ABO and Rh group [Type] in Blood

3.30

1.50

2.3

1.7

—

(3033658) Prothrombin time (PT) actual/Normal

3.19

1.46

5.9

3.6

69.38

87.82

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

2.66

1.15

6.3

2.1

2996.00

600.83

u/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.66

1.15

9.0

3.4

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.83

1.12

15.8

8.9

101.60

102.18

mmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.83

1.12

5.0

2.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.48

0.97

10.0

3.0

—

(3015736) pH of Urine

2.48

0.89

22.6

2.7

—

(40768804) Tissue Pathology biopsy report

2.01

0.74

2.3

2.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.13

0.73

1.4

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

2.08

0.70

7.7

4.4

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.92

0.63

14.8

2.9

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.90

0.56

19.6

4.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.93

0.53

3.2

2.8

—

(3012516) Albumin [Mass/volume] in Urine

1.68

0.45

1.6

2.9

9.00

24.93

mg/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.43

0.0

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.43

0.0

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

120

0.73

0.25

11.0

5.6

1.50

1.83

mu/l

0.53

110

(21494755) Public health laboratory ask at order entry panel

0.00

0.22

0.0

1.1

—

(3019225) pH of Specimen

0.00

0.22

0.0

2.7

—

(3044889) 12 lead EKG panel

1.39

0.22

6.6

4.0

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.22

0.0

1.3

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.21

0.0

11.8

—

(3003338) MCHC [Mass/volume]

119

0.76

0.12

51.5

16.5

331.73

332.80

g/l

0.12

119

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.0

1.4

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

1.6

—

26.29

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3025245) SCL-70 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.6

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

1.8

—

4.64

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.2

—

27.40

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.0

5.0

—

29.84

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.0

2.2

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.0

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

1.8

—

9.28

—

(1616796) Gas panel - Central venous blood

0.00

0.0

1.4

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

12.31

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

2.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.4

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

3.0

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.6

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

1.06

0.00

3.8

5.2

1.18

2.29

ug/l

—

(3010421) pH of Blood

0.00

0.0

2.2

—

7.43

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_NONAIHA_DRUG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_NONAIHA_DRUG.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_NONAIHA_DRUG – Drug-induced nonautoimmune haemolytic anaemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced nonautoimmune haemolytic anaemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints