hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
774 |
4. Check minimum number of eventsNone |
774 |
5. Include endpoints |
838 |
6. Filter based on genotype QC (FinnGen only) |
838 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D55-D59
- Name in latin
- Anaemia haemolytica acquisita
Similar endpoints
↥List of similar endpoints to
Acquired haemolytic anaemia
based on the number of shared cases.
Similar with more cases:
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7041 | 3819 | 3130 |
| Only index persons | 4923 | 2698 | 2225 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.11 | 0.09 |
| Only index persons | 0.09 | 0.10 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 65.04 | 66.51 | 63.16 |
| Only index persons | 61.86 | 62.50 | 61.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 838 | 426 | 412 |
| Unadjusted period prevalence (%) | 0.16 | 0.15 | 0.18 |
| Median age at first event (years) | 60.79 | 55.04 | 66.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 763
- Matched controls
- 7631
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
323.0
347
*
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
249.0
225
*
D64.9
ICD-10 Finland
Anaemia, unspecified
10.1
125.2
281
415
XW000
NOMESCO Finland
Bone marrow biopsy
17.3
108.0
178
132
WW500
NOMESCO Finland
Blood transfusion
10.9
69.1
139
152
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.8
59.4
230
623
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
54.8
52
*
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
53.8
51
*
ZX120
NOMESCO Finland
Intravenous
5.6
52.5
171
376
H02AB06
ATC
prednisolone; systemic
3.2
51.1
478
2615
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.0
50.1
111
141
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
49.5
47
*
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
48.4
46
*
TK800
NOMESCO Finland
Hemodialysis
12.5
43.5
80
71
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
43.1
433
2370
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
42.9
356
1719
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
11.0
38.9
76
76
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
37.8
36
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.7
37.7
116
233
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
21.9
37.5
55
27
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
37.4
309
1450
B03XA02
ATC
darbepoetin alfa; parenteral
14.5
36.9
63
47
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
18.8
36.3
56
32
L04AA06
ATC
mycophenolic acid; systemic
12.8
36.0
65
55
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
30.0
36.0
48
17
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
13.8
33.9
59
46
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
30.3
32.3
43
15
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
19.3
32.2
49
27
H02AB07
ATC
prednisone; oral
3.4
30.3
170
598
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
12.3
30.1
55
48
M04AA01
ATC
allopurinol; systemic
3.3
30.0
172
614
127
Kela drug reimbursment
Transplant complication
12.0
29.8
55
49
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.1
29.5
68
91
R50.9
ICD-10 Finland
Fever, unspecified
3.3
29.4
166
585
C03CA01
ATC
furosemide; systemic
2.5
29.4
316
1670
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.6
28.6
106
259
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.7
28.2
101
238
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.4
27.5
107
274
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.0
27.3
118
333
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.5
26.9
141
467
B03XA01
ATC
erythropoietin; parenteral
15.5
26.8
44
30
Z94.0
ICD-10 Finland
Kidney transplant status
12.8
26.3
47
39
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.6
26.2
96
231
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
+∞
26.2
25
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
96.8
25.8
28
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
25.5
258
1295
Z49.1
ICD-10 Finland
Extracorporeal dialysis
11.8
25.5
47
42
L04AX01
ATC
azathioprine; systemic
5.8
25.2
74
139
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
25.0
179
734
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
15.6
24.5
40
27
2839X
ICD-9 Finland
Acquired haemolytic anaemias, Acquired haemolytic anaemia, unspecified
+∞
24.1
23
*
L04AD01
ATC
ciclosporin; systemic
8.8
24.0
52
63
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
23.0
218
1049
A11CC03
ATC
alfacalcidol; systemic
6.9
22.5
57
88
UJF32
NOMESCO Finland
Coloscopy
2.4
22.4
244
1260
ZXD05
NOMESCO Finland
Urgent procedure
2.2
21.5
280
1565
JN4BD
NOMESCO Finland
Extensive body CT
3.1
21.1
127
461
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
31.0
20.7
27
9
A02BC02
ATC
pantoprazole; systemic
2.1
20.7
513
3764
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
11.7
20.6
38
34
A12AA04
ATC
calcium carbonate; oral
8.0
20.6
47
62
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
14.8
20.5
34
24
L03AA02
ATC
filgrastim; parenteral
7.2
20.4
50
74
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
7.3
20.2
49
71
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.1
20.1
65
137
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
19.8
183
857
D64.8
ICD-10 Finland
Other specified anaemias
9.2
19.6
41
47
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
5.9
19.1
54
97
2830A
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA PRIMARIA]
+∞
18.8
18
*
1XC02
NOMESCO Finland
NA
17.7
18.8
29
17
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
13.4
18.0
31
24
L04AA01
ATC
[U] ciclosporin; systemic
8.8
17.9
38
45
N18.0
ICD-10 Finland
End-stage renal disease
9.0
17.6
37
43
JN4AD
NOMESCO Finland
Body CT examination
3.4
17.5
91
296
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.8
17.4
59
131
D70.89
ICD-10 Finland
Neutropenic splenomegaly
11.5
17.4
32
29
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
5.2
17.1
54
111
6BA02
NOMESCO Finland
NA
51.2
17.1
20
*
WW400
NOMESCO Finland
Plasmaferesis
35.9
16.7
21
6
D59.6
ICD-10 Finland
Haemoglobinuria due to haemolysis from other external causes
+∞
16.7
16
*
B01AA03
ATC
warfarin; systemic
2.2
16.6
206
1104
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
11.5
16.4
30
27
I35.0
ICD-10 Finland
Aortic (valve) stenosis
3.5
16.3
80
249
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
30.8
16.2
21
7
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.2
16.1
193
1018
V03AE01
ATC
polystyrene sulfonate; oral
8.6
15.9
34
41
V03AE02
ATC
sevelamer; oral
17.7
15.7
24
14
WW200
NOMESCO Finland
Immunization
5.5
15.5
46
88
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.0
15.2
62
165
Z3231
NOMESCO Finland
Registered nurse
2.0
15.2
243
1442
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
20.5
15.2
22
11
B03BA03
ATC
hydroxocobalamin; parenteral
3.4
15.0
74
232
L01AA01
ATC
cyclophosphamide; systemic
18.8
14.7
22
12
D59.2
ICD-10 Finland
Drug-induced nonautoimmune haemolytic anaemia
+∞
14.6
14
*
L01AA02
ATC
chlorambucil; oral
81.7
14.6
16
*
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
6.2
14.5
39
66
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
9.7
14.5
29
31
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.5
14.4
69
211
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
7.7
14.0
32
43
J01MA12
ATC
levofloxacin; systemic
2.2
14.0
168
878
B01AB05
ATC
enoxaparin; parenteral
1.9
13.8
243
1483
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
76.5
13.6
15
*
H02AB09
ATC
hydrocortisone; systemic
5.8
13.6
38
68
137
Kela drug reimbursment
Uraemia requiring dialysis
9.0
13.6
28
32
3AC01
NOMESCO Finland
NA
10.3
13.5
26
26
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
142.4
13.5
14
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
142.4
13.5
14
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
13.5
179
975
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
13.1
13.5
23
18
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
8.1
13.2
29
37
KA1AE
NOMESCO Finland
Kidney ultrasound examination
5.2
13.1
40
80
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
13.0
157
821
GD1AD
NOMESCO Finland
Thorax CT examination
3.7
12.9
57
163
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
8.3
12.9
28
35
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
9.9
12.8
25
26
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
7.7
12.8
29
39
ZXE20
NOMESCO Finland
More than three and less than five hours
2.3
12.6
132
645
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
17.7
12.6
19
11
122
Kela drug reimbursment
Aplastic anaemia
132.0
12.5
13
*
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
132.0
12.5
13
*
B01AB10
ATC
tinzaparin; parenteral
3.0
12.4
75
271
R4110
NOMESCO Finland
Physiotherapy
1.9
12.3
219
1333
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
12.3
223
1364
N18.8
ICD-10 Finland
Other chronic renal failure
4.2
12.3
46
114
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
38.2
12.2
15
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.4
12.1
58
178
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
27.2
12.1
16
6
A04AA01
ATC
ondansetron; systemic, rectal
3.1
12.1
68
234
J01MA14
ATC
moxifloxacin; systemic
2.6
11.9
88
361
Z2221
NOMESCO Finland
Medical doctor
1.9
11.9
224
1388
TGC00
NOMESCO Finland
Bronchial lavation
5.1
11.9
37
76
H02AB04
ATC
methylprednisolone; systemic
2.2
11.8
129
643
M31.1
ICD-10 Finland
Thrombotic microangiopathy
66.0
11.6
13
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
11.3
11.6
21
19
M05BA04
ATC
alendronic acid; oral
2.6
11.6
86
353
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
11.6
136
701
JMA10
NOMESCO Finland
Transabdominal total splenectomy
13.9
11.5
19
14
28398
ICD-8 Finland
Acquired haemolytic anaemias, Aliae definitar
+∞
11.5
11
*
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
11.5
11
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.8
11.5
76
292
B82
ICPC
Anaemia other/unspecified
4.9
11.5
37
79
ZX108
NOMESCO Finland
Inhalation
12.0
11.4
20
17
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
3.8
11.2
47
130
A41.9
ICD-10 Finland
Sepsis, unspecified
3.8
11.2
46
125
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.3
11.1
40
96
SPAT1255
SPAT
Intravenous administration of medicine
2.9
11.0
68
249
J01FF01
ATC
clindamycin; systemic
1.8
11.0
210
1300
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
44.0
10.9
13
*
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
9.8
10.8
21
22
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
13.1
10.7
18
14
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
10.6
101
471
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.7
10.5
72
281
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
16.3
10.4
16
10
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
23.7
10.3
14
6
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
6.0
10.2
27
46
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.2
10.2
38
95
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
10.1
98
460
C09AA02
ATC
enalapril; systemic
1.9
10.1
173
1027
PJA10
NOMESCO Finland
Exploration of lymph nodes
8.6
10.1
21
25
TPH07
NOMESCO Finland
Cathetrisation of artery
2.3
10.1
100
475
Z2446
NOMESCO Finland
Social worker
2.7
10.1
70
276
Z49.2
ICD-10 Finland
Other dialysis
10.2
10.1
19
19
Z49.0
ICD-10 Finland
Preparatory care for dialysis
7.4
10.0
23
32
N02AA05
ATC
oxycodone; systemic
2.1
10.0
123
643
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.4
10.0
35
82
196
Kela drug reimbursment
Paricalcitol and cinacalcet
12.4
9.9
17
14
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
12.4
9.9
17
14
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
4.7
9.8
32
70
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
9.7
285
2002
SPAT1088
SPAT
Blood transfusion
13.6
9.7
16
12
WX002
NOMESCO Finland
Sedation and analgesia
1.9
9.7
158
921
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
8.0
9.7
21
27
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
9.6
85
384
B05DB
ATC
Hypertonic solutions
9.2
9.6
19
21
ZXE00
NOMESCO Finland
One hour or less
1.7
9.5
298
2129
TK810
NOMESCO Finland
Hemofiltration
15.3
9.5
15
10
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.2
9.5
50
166
L03AA13
ATC
pegfilgrastim; parenteral
3.9
9.4
38
102
L01XX52
ATC
venetoclax; oral
101.2
9.4
10
*
399
Kela drug reimbursment
Venetoclax
101.2
9.4
10
*
C90.0
ICD-10 Finland
Multiple myeloma
7.0
9.4
22
32
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
13.9
9.2
15
11
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
9.2
92
441
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.3
9.1
45
143
N02AX02
ATC
tramadol; systemic, rectal
1.6
9.0
309
2253
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.2
8.9
33
82
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
24.3
8.9
12
5
R06.0
ICD-10 Finland
Dyspnoea
1.8
8.9
189
1204
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.9
8.8
133
753
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.0
8.8
34
88
H03AA01
ATC
levothyroxine sodium; systemic
1.8
8.8
164
998
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.1
8.7
33
84
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
6.7
8.7
21
32
L01BB05
ATC
fludarabine; systemic
50.6
8.7
10
*
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
50.6
8.7
10
*
C07AB07
ATC
bisoprolol; oral
1.6
8.7
361
2755
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
3.1
8.7
46
154
ZX112
NOMESCO Finland
Subcutaneous
4.4
8.6
30
71
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
16.5
8.6
13
8
C08CA01
ATC
amlodipine; oral
1.6
8.5
271
1927
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.5
8.5
39
117
I34.1
ICD-10 Finland
Mitral (valve) prolapse
4.0
8.4
32
82
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
91.0
8.4
9
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
8.4
272
1943
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
8.3
8
*
AC1
HP
MVR mechanical
+∞
8.3
8
*
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
5.9
8.3
22
38
A05AA02
ATC
ursodeoxycholic acid; oral
5.9
8.3
22
38
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
10.9
8.3
15
14
B05DA
ATC
Isotonic solutions
7.2
8.3
19
27
J05AB11
ATC
valaciclovir; oral
2.0
8.3
107
572
WX892
NOMESCO Finland
Monitored bed care
2.3
8.3
77
357
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
6.6
8.2
20
31
C08CA05
ATC
nifedipine; systemic
2.5
8.2
63
265
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
33.7
8.1
10
*
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
33.7
8.1
10
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
8.1
173
1098
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
22.3
8.0
11
5
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
22.3
8.0
11
5
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.6
7.9
57
230
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.8
7.8
31
83
104
Kela drug reimbursment
Thyroid insufficiency
2.5
7.8
58
240
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
10.9
7.8
14
13
K83
ICPC
Heart valve disease NOS
7.1
7.8
18
26
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
7.8
362
2814
A02BC01
ATC
omeprazole; systemic
1.6
7.8
213
1450
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
4.3
7.8
27
64
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
7.8
78
374
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
4.0
7.7
29
74
E87.5
ICD-10 Finland
Hyperkalaemia
4.8
7.7
24
51
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.1
7.6
88
448
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
25.3
7.6
10
*
1512
Kela drug reimbursment
Ibrutinib
25.3
7.6
10
*
Z99.2
ICD-10 Finland
Dependence on renal dialysis
25.3
7.6
10
*
A07AA09
ATC
vancomycin; oral
6.3
7.6
19
31
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.7
7.6
50
194
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
4.2
7.5
27
66
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.6
7.5
32
92
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.1
7.4
80
396
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.0
7.4
40
137
A41.8
ICD-10 Finland
Other specified sepsis
4.8
7.4
23
49
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
3.5
7.4
32
93
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
11.0
7.3
13
12
I34.01
ICD-10 Finland
Mitral (valve) regurgitation NOS or of specified cause, except rheumatic
11.0
7.3
13
12
B99
ICD-10 Finland
Other and unspecified infectious diseases
4.6
7.3
24
54
R59.9
ICD-10 Finland
Enlarged lymph nodes, unspecified
9.5
7.3
14
15
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
+∞
7.3
7
*
2830X
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA NUD]
+∞
7.3
7
*
D55.9
ICD-10 Finland
Anaemia due to enzyme disorder, unspecified
+∞
7.3
7
*
N08.2*D89.82
ICD-10 Finland
Nepropathy caused by deposition of the light chain of the immunoglobulins
+∞
7.3
7
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
7.3
7
*
J01MA02
ATC
ciprofloxacin; systemic
1.6
7.3
284
2107
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
5.5
7.3
20
37
R31
ICD-10 Finland
Unspecified haematuria
2.0
7.2
89
464
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
3.4
7.2
33
100
P01BA02
ATC
hydroxychloroquine; oral
2.3
7.2
65
298
A06AD11
ATC
lactulose; oral
1.9
7.2
113
647
1AA09
NOMESCO Finland
NA
30.3
7.2
9
*
6753
FHL
Transabdominal splenectomy
30.3
7.2
9
*
J02AC03
ATC
voriconazole; systemic
20.2
7.1
10
5
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.1
7.1
26
65
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
12.2
7.1
12
10
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
10.1
7.0
13
13
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
7.0
490
5607
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.1
7.0
79
398
XG410
NOMESCO Finland
Flow-volume spirometry
2.9
7.0
41
148
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.4
7.0
17
27
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
3.6
6.9
29
82
Z94.4
ICD-10 Finland
Liver transplant status
13.9
6.9
11
8
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.9
6.9
40
143
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.6
6.9
188
1277
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.1
6.8
78
394
B81
ICPC
Anaemia vit B12/folate deficiency
2.9
6.8
39
137
AC4
HP
MVP
9.4
6.8
13
14
WX882
NOMESCO Finland
High dependency care
3.0
6.8
37
128
N19
ICD-10 Finland
Unspecified kidney failure
3.0
6.8
37
128
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
6.8
122
733
A10AE04
ATC
insulin glargine; parenteral
2.2
6.8
71
346
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.3
6.8
60
273
L04AA05
ATC
[U] tacrolimus; systemic
40.4
6.8
8
*
Z94.1
ICD-10 Finland
Heart transplant status
40.4
6.8
8
*
V03AE04
ATC
calcium acetate and magnesium carbonate; systemic
40.4
6.8
8
*
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
40.4
6.8
8
*
D46.7
ICD-10 Finland
Other myelodysplastic syndromes
16.9
6.8
10
6
390
Kela drug reimbursment
Ibrutinib
16.9
6.8
10
6
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.0
6.7
80
414
C07AB02
ATC
metoprolol; systemic
1.7
6.7
164
1076
UJF92
NOMESCO Finland
Capsular endoscopy
4.1
6.6
24
60
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
6.6
177
1193
B80
ICPC
Iron deficiency anaemia
4.4
6.6
22
51
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.0
6.5
35
120
D86.0
ICD-10 Finland
Sarcoidosis of lung
6.9
6.5
15
22
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
3.1
6.5
33
109
D70.82
ICD-10 Finland
Drug-induced neutropenia
4.7
6.4
20
43
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
70.4
6.4
7
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
70.4
6.4
7
*
205
Kela drug reimbursment
Chronic hypertension
1.6
6.4
218
1559
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.5
6.4
225
1625
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
6.4
81
431
R80
ICD-10 Finland
Isolated proteinuria
8.2
6.3
13
16
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
6.3
101
581
AA1AD
NOMESCO Finland
CT of head and brain
1.6
6.3
177
1202
A46
ICD-10 Finland
Erysipelas
1.8
6.3
106
620
UJF30
NOMESCO Finland
Ileoscopy through colon
2.0
6.3
75
389
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
11.1
6.3
11
10
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
9.4
6.3
12
13
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
18.2
6.3
9
5
L01XE27
ATC
[U] ibrutinib; oral
18.2
6.3
9
5
N28.9
ICD-10 Finland
Disorder of kidney and ureter, unspecified
+∞
6.3
6
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.4
6.2
48
204
AB1
HP
AVR mechanical
26.9
6.2
8
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
7.1
6.2
14
20
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
7.1
6.2
14
20
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.5
6.2
47
196
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.8
6.2
24
64
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
5.1
6.2
18
36
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
5.1
6.2
18
36
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
6.3
6.2
15
24
C03DA01
ATC
spironolactone; oral
1.9
6.1
89
498
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
6.1
180
1239
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.7
6.0
125
784
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
2.2
6.0
59
280
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.0
6.0
80
430
JN6AD
NOMESCO Finland
CT of torso and neck
5.6
6.0
16
29
Mortality – FinRegistry
↥Association
Association between endpoint D3_ACQHAEMOLYTICANAEMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIA | 2.809 [2.38, 3.31] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.164 |
During the follow-up period (1.1.1998 — 31.12.2019), 1010 out of 2437 females with D3_ACQHAEMOLYTICANAEMIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIA | 2.96 [2.45, 3.58] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.112 |
During the follow-up period (1.1.1998 — 31.12.2019), 846 out of 2047 males with D3_ACQHAEMOLYTICANAEMIA died.
Mortality risk
Mortality risk for people of age
years, who have D3_ACQHAEMOLYTICANAEMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | 0.614% |
| 5 | 1.926% | 3.519% |
| 10 | 4.031% | 8.893% |
| 15 | 7.254% | 17.108% |
| 20 | 12.953% | 28.787% |
Relationships between endpoints
↥Index endpoint: D3_ACQHAEMOLYTICANAEMIA – Acquired haemolytic anaemia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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