Drug-induced autoimmune haemolytic anaemia

D3_AIHA_DRUG

hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D59.0# Hospital discharge: ICD-9 — 2830B Hospital discharge: ICD-8 — 28391 Cause of death: ICD-10 — D59.0# Cause of death: ICD-9 — 2830B Cause of death: ICD-8 — 28391 2 out of 7 registries used, show all original rules.	48
4. Check minimum number of events None	48
5. Include endpoints None	48
6. Filter based on genotype QC (FinnGen only)	48

Control definitions (FinnGen only)

Control exclude: D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D59
Name in latin: Anaemia autoimmunis haemolytica medicamentis provocata

NAME	D3_AIHA_DRUG
CONTROL_EXCLUDE	D3_HAEMOLYTICANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D590
HD_ICD_9	2830B
HD_ICD_8	28391
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D590
COD_ICD_9	2830B
COD_ICD_8	28391
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Drug-induced autoimmune haemolytic anaemia based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	547	318	222
Only index persons	353	208	145
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	61.21	62.60	59.20
Only index persons	53.14	57.03	47.57

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	48	27	21
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	51.40	48.72	54.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

12.68

9.92

2.8

2.0

—

(3025159) Blasts/100 leukocytes in Blood

4.16

3.58

7.7

3.5

0.0

—

(3042936) Bacteria identified in Isolate by Culture

3.44

3.45

2.5

1.4

—

(3019309) Folate [Moles/volume] in Red Blood Cells

3.16

3.26

1.5

1.7

1328.9

1154.6

nmol/l

0.32

(3021440) Promyelocytes/100 leukocytes in Blood

3.78

3.16

7.8

3.3

0.0

0.1

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

10.94

3.04

1.2

1.4

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

143

2.79

3.00

5.3

3.6

25.8

22.5

ng/l

0.27

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

104

2.81

2.94

2.6

2.5

2101.0

957.6

ng/l

0.68

(3017181) Myelocytes/100 leukocytes in Blood

3.56

2.91

7.8

3.4

0.2

0.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.87

2.86

9.1

5.7

—

(3029937) Albumin [Presence] in Urine by Test strip

2.73

2.68

9.3

4.2

0.0

estimate

—

(3013115) Eosinophils [#/volume] in Blood

195

2.67

2.63

12.1

5.2

0.2

e9/l

0.38

173

(40760888) Immunoglobulin light chains.free panel - Serum

7.80

2.61

7.4

1.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

6.81

2.43

1.2

1.3

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.72

2.05

6.0

2.3

127.6

127.8

g/l

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

4.12

2.00

4.3

2.9

25.4

24.8

mmol/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

4.12

2.00

4.2

2.3

0.8

0.7

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

4.12

2.00

4.2

2.3

0.7

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

130

2.28

1.99

9.2

4.2

—

(3018418) pH of Serum or Plasma

115

2.27

1.92

8.7

4.2

7.4

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

3.65

1.81

4.3

2.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

162

2.13

1.75

2.4

2.0

93.7

100.6

pmol/l

0.38

(3002256) Pathology report gross observation

2.67

1.74

1.2

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.22

1.71

9.6

3.8

—

(3012544) pH of Venous blood

2.79

1.68

5.4

3.1

—

(3013512) EKG study

104

2.17

1.67

6.7

4.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

183

2.09

1.66

9.1

5.7

0.0

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

185

2.05

1.59

7.9

4.1

0.0

estimate

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.59

1.56

7.0

3.0

44.0

52.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

2.53

1.50

12.8

9.0

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.53

1.50

1.8

1.5

—

(42870588) Differential panel, method unspecified - Blood

117

2.03

1.47

12.3

4.8

—

(40758558) Short blood count panel - Blood

101

2.06

1.44

7.9

7.8

—

(3023368) Bacteria identified in Blood by Culture

110

2.02

1.42

6.7

4.4

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.16

1.39

1.8

2.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.71

1.35

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

184

1.90

1.32

8.0

3.9

0.0

estimate

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.46

1.32

3.5

1.2

—

(3026782) Osmolality of Urine

2.07

1.26

7.8

3.0

528.9

559.4

mosm/kgh2o

0.20

(3044640) Blood type and Crossmatch panel - Blood

124

1.88

1.21

4.3

2.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

133

1.86

1.21

3.3

2.6

46.7

27.8

u/l

0.50

120

(3020630) Protein [Mass/volume] in Serum or Plasma

2.20

1.19

5.4

1.3

68.1

66.5

g/l

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

2.55

1.18

1.3

1.5

—

(3002032) Base excess in Venous blood by calculation

2.47

1.16

6.0

3.2

0.8

2.2

mmol/l

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.98

1.04

13.3

8.1

103.1

103.7

mmol/l

—

(3019225) pH of Specimen

2.07

0.88

7.7

3.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.84

0.86

1.9

1.7

—

(3026008) Bacteria identified in Urine by Culture

136

1.66

0.85

4.2

2.5

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.88

0.83

3.1

1.5

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

1.80

0.80

1.3

1.4

21.0

41.3

iu/ml

—

(3015736) pH of Urine

148

1.60

0.77

4.0

3.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

1.63

0.69

5.9

4.3

18.8

17.4

mg/mmol

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.72

0.65

2.0

1.8

—

(40761536) Microorganisms panel - Urine sediment

1.74

0.63

13.4

3.7

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

193

1.49

0.61

6.0

3.8

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.65

0.58

3.6

2.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

265

1.48

0.56

9.1

4.3

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

117

0.62

0.54

3.6

4.4

1.4

2.0

ug/l

—

106

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

1.53

0.53

2.1

2.2

—

(3012516) Albumin [Mass/volume] in Urine

1.46

0.43

5.4

3.3

119.1

131.5

mg/l

—

(40768797) Stomach Pathology biopsy report

1.40

0.43

1.5

1.2

—

(1002224) Polysomnography panel

0.00

0.42

0.0

1.0

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.42

0.0

1.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.42

0.0

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.42

0.0

1.0

—

(4035726)

1.52

0.42

1.4

1.2

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.41

0.0

1.6

—

1.4

—

(3021960) Folate [Moles/volume] in Serum or Plasma

101

1.39

0.36

2.2

1.7

19.7

24.3

nmol/l

0.46

(3032080) INR in Blood by Coagulation assay

150

1.32

0.33

31.2

5.7

1.5

1.1

inr

—

(3000494) Fungus identified in Specimen by Culture

1.32

0.31

1.4

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.40

0.31

3.3

1.7

—

(40761511) CBC panel - Blood by Automated count

407

1.54

0.28

34.1

12.5

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

406

0.79

0.27

33.0

15.9

99.7

75.6

umol/l

0.69

406

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

396

1.48

0.26

30.6

13.5

16.3

23.5

mg/l

1.72

316

(1761868) Lipid panel - Serum or Plasma

126

1.28

0.25

3.3

3.1

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

1.34

0.25

3.7

2.9

2.4

2.5

mmol/l

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.35

0.24

2.2

1.5

—

(40768804) Tissue Pathology biopsy report

166

1.24

0.23

2.4

2.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

24.5

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.21

0.0

1.2

—

(3027450) Sjogrens syndrome-B extractable nuclear Ab [Units/volume] in Serum

0.00

0.21

0.0

1.9

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.21

0.0

1.1

—

(3027008) Opiates [Presence] in Urine

0.00

0.21

0.0

1.1

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.21

0.0

1.1

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.5

—

(3016879) Cocaine [Presence] in Urine

0.00

0.21

0.0

1.1

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.21

0.0

5.7

—

33.7

—

(3022145) Colonoscopy Study observation

1.26

0.21

1.2

1.4

—

(40768793) Breast Pathology biopsy report

0.00

0.21

0.0

1.2

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.20

0.0

1.7

—

(3014051) Protein [Presence] in Urine by Test strip

0.00

0.20

0.0

1.8

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.20

0.0

1.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

0.76

0.17

5.2

3.1

18.0

26.0

ng/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

143

1.18

0.14

6.9

3.1

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

372

0.87

0.08

5.1

4.5

6.2

6.0

mmol/l

0.29

340

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.08

0.08

1.5

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

243

0.90

0.08

3.6

3.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.11

0.03

4.3

3.8

—

(3044889) 12 lead EKG panel

263

1.06

0.01

3.7

4.0

—

(3009542) Hematocrit [Volume Fraction] of Blood

357

1.03

0.00

27.8

14.4

35.9

39.3

1.06

264

(36304419) Bacteria [Presence] in Urine

114

0.95

0.00

5.9

3.1

—

(3003694) ABO and Rh group [Type] in Blood

118

1.02

0.00

1.3

1.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

352

0.98

0.00

7.6

5.4

40.7

39.7

mmol/mol

0.21

329

(3031040) Bacteria [#/volume] in Urine by Automated count

268

1.02

0.00

6.7

4.5

—

94.3

—

(40768800) Prostate Pathology biopsy report

0.00

0.0

1.0

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.5

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

0.0

1.5

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.0

1.3

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.1

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.5

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

1.5

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.2

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.8

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.8

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.0

1.1

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

1.5

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.0

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

0.0

2.9

—

234.0

—

(40768795) Lymph node Pathology biopsy report

0.00

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.5

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.0

1.2

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

1.6

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.2

—

21.5

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

1.5

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

4.8

—

217.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.7

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

0.0

1.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.3

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

0.0

2.6

—

(4034850)

0.00

0.0

11.9

—

(4268621)

0.00

0.0

1.8

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.0

—

(3039162) Centromere protein B Ab [Units/volume] in Serum

0.00

0.0

1.8

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

3.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_AIHA_DRUG and mortality.

Females

Parameter	HR [95% CI]	p-value
D3_AIHA_DRUG	2.793 [1.83, 4.26]	< 0.001
Birth year	0.991 [0.98, 1.0]	0.047

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 199 females with D3_AIHA_DRUG died.

Males

Parameter	HR [95% CI]	p-value
D3_AIHA_DRUG	3.119 [1.76, 5.53]	< 0.001
Birth year	0.989 [0.98, 1.0]	0.023

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 146 males with D3_AIHA_DRUG died.

Mortality risk

Mortality risk for people of age

years, who have D3_AIHA_DRUG.

N-year risk	Females	Males
1	0.302%	0.613%
5	1.661%	3.818%
10	3.544%	9.049%
15	6.681%	16.557%
20	11.785%	27.62%

Relationships between endpoints

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Index endpoint: D3_AIHA_DRUG – Drug-induced autoimmune haemolytic anaemia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced autoimmune haemolytic anaemia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints