No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
447 |
4. Check minimum number of eventsNone |
447 |
5. Include endpointsNone |
447 |
6. Filter based on genotype QC (FinnGen only) |
429 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D59
- Name in latin
- Aliae anaemiae autoimmunes haemolyticae
Similar endpoints
↥List of similar endpoints to
Other autoimmune haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3078 | 1652 | 1390 |
| Only index persons | 2344 | 1276 | 1068 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 68.37 | 69.80 | 66.65 |
| Only index persons | 67.43 | 68.54 | 66.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 429 | 223 | 206 |
| Unadjusted period prevalence (%) | 0.09 | 0.08 | 0.09 |
| Median age at first event (years) | 65.32 | 62.98 | 67.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 447
- Matched controls
- 4470
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
307.7
425
*
XW000
NOMESCO Finland
Bone marrow biopsy
23.0
183.3
150
96
D64.9
ICD-10 Finland
Anaemia, unspecified
10.8
132.2
190
286
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
81.8
76
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
29.7
80.9
55
21
WW500
NOMESCO Finland
Blood transfusion
10.7
76.1
92
106
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
44.3
73.0
44
11
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
9.3
70.3
95
126
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
24.4
68.5
50
23
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
34.8
68.3
44
14
H02AB06
ATC
prednisolone; systemic
5.6
59.0
343
1650
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
25.0
57.0
41
18
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.4
55.9
141
350
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
11.5
50.3
55
54
ZX120
NOMESCO Finland
Intravenous
5.3
45.6
109
255
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.7
41.3
258
1199
M04AA01
ATC
allopurinol; systemic
3.4
25.3
115
417
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.9
24.9
59
134
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
8.5
24.2
32
40
JN4AD
NOMESCO Finland
Body CT examination
3.7
24.2
87
271
2830A
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA PRIMARIA]
+∞
23.1
22
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.7
22.8
273
1643
L04AX01
ATC
azathioprine; systemic
6.0
22.2
41
74
H02AB07
ATC
prednisone; oral
3.2
21.6
105
394
JN4BD
NOMESCO Finland
Extensive body CT
3.4
20.9
86
291
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
19.9
94
345
L03AA02
ATC
filgrastim; parenteral
5.6
18.8
37
71
1XC02, ,
NOMESCO Finland
34.5
18.1
23
7
TPH04
NOMESCO Finland
Cathetrisation of vein
2.6
18.1
137
646
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
17.6
177
950
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
66.0
16.9
19
*
A02BC02
ATC
pantoprazole; systemic
2.5
16.1
339
2469
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
15.7
15
*
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
14.7
14
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.4
14.4
37
89
B03BA03
ATC
hydroxocobalamin; parenteral
3.6
14.1
50
152
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
6.1
14.1
25
43
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
31.2
14.0
18
6
L01AA02
ATC
chlorambucil; oral
24.7
13.9
19
8
H02AB09
ATC
hydrocortisone; systemic
6.0
13.3
24
42
M05BA04
ATC
alendronic acid; oral
2.9
13.0
66
250
6BA02, ,
NOMESCO Finland
51.6
12.9
15
*
R50.9
ICD-10 Finland
Fever, unspecified
2.5
12.8
95
436
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
12.8
155
879
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
12.6
12
*
L01AA01
ATC
cyclophosphamide; systemic
25.2
12.5
17
7
UJF32
NOMESCO Finland
Coloscopy
2.2
12.5
148
830
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
12.4
122
634
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
11.0
12.4
23
22
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
5.1
11.8
25
51
JMA10
NOMESCO Finland
Transabdominal total splenectomy
19.6
11.7
17
9
WW200
NOMESCO Finland
Immunization
5.5
11.7
23
44
D64.8
ICD-10 Finland
Other specified anaemias
8.7
11.4
24
29
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.6
11.2
38
112
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.2
11.1
45
149
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.0
11.0
52
189
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
4.4
11.0
28
67
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.8
11.0
58
224
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
18.4
10.8
16
9
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
61.5
10.7
12
*
120
Kela drug reimbursment
Hypogammaglobulinaemia
61.5
10.7
12
*
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
11.6
10.6
19
17
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.9
10.5
31
83
399
Kela drug reimbursment
Venetoclax
24.0
10.3
14
6
L01XX52
ATC
venetoclax; oral
24.0
10.3
14
6
TK800
NOMESCO Finland
Hemodialysis
5.2
10.1
21
42
J05AB11
ATC
valaciclovir; oral
2.3
10.1
85
411
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
8.4
9.9
21
26
ZX112
NOMESCO Finland
Subcutaneous
4.8
9.6
22
48
B03XA02
ATC
darbepoetin alfa; parenteral
5.0
9.6
21
44
6753
FHL
Transabdominal splenectomy
102.1
9.4
10
*
A41.9
ICD-10 Finland
Sepsis, unspecified
3.7
9.4
30
85
A04AA01
ATC
ondansetron; systemic, rectal
2.8
9.4
50
194
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
14.1
9.2
15
11
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
14.1
9.2
15
11
L04AA06
ATC
mycophenolic acid; systemic
8.0
9.2
20
26
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.1
9.1
96
507
A10AB05
ATC
insulin aspart; parenteral
2.8
9.0
47
180
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
8.2
8.9
19
24
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.6
8.8
29
84
JN6AD
NOMESCO Finland
CT of torso and neck
6.8
8.8
21
32
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
51.0
8.7
10
*
C03CA01
ATC
furosemide; systemic
1.8
8.6
176
1167
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
20.5
8.5
12
6
B82
ICPC
Anaemia other/unspecified
4.1
8.4
23
58
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.1
8.4
35
118
J01MA12
ATC
levofloxacin; systemic
2.0
8.4
101
560
2830X
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA NUD]
+∞
8.4
8
*
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
8.4
8
*
TGC00
NOMESCO Finland
Bronchial lavation
4.0
8.4
24
63
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.9
8.3
41
152
JN3AD
NOMESCO Finland
Abdominal CT examination
2.3
8.2
63
292
SPAT1088
SPAT
Blood transfusion
17.6
8.1
12
7
PJA10
NOMESCO Finland
Exploration of lymph nodes
9.2
8.1
16
18
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
22.5
8.0
11
5
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
22.5
8.0
11
5
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.8
8.0
40
150
D70.89
ICD-10 Finland
Neutropenic splenomegaly
8.0
7.9
17
22
L03AA13
ATC
pegfilgrastim; parenteral
3.1
7.8
33
112
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
7.7
230
1686
1518, ,
Kela drug reimbursment
18.7
7.6
11
6
GD1AD
NOMESCO Finland
Thorax CT examination
2.8
7.6
38
142
ZX108
NOMESCO Finland
Inhalation
12.1
7.6
13
11
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.7
7.2
23
65
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
20.4
7.2
10
5
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.9
7.1
100
583
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
7.0
91
517
L04AD01
ATC
ciclosporin; systemic
7.7
7.0
15
20
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
14.1
6.9
11
8
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.1
6.9
28
93
A10AC01
ATC
insulin (human); parenteral
2.4
6.9
47
206
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
3.7
6.8
21
58
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.1
6.8
29
99
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
9.5
6.8
13
14
E87.5
ICD-10 Finland
Hyperkalaemia
4.4
6.8
17
40
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
17.0
6.8
10
6
B01AB05
ATC
enoxaparin; parenteral
1.7
6.7
155
1050
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
4.3
6.6
17
41
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
8.9
6.6
13
15
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
70.8
6.4
7
*
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
70.8
6.4
7
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
70.8
6.4
7
*
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
70.8
6.4
7
*
1AA09, ,
NOMESCO Finland
70.8
6.4
7
*
R06.0
ICD-10 Finland
Dyspnoea
1.7
6.4
138
913
B03XA01
ATC
erythropoietin; parenteral
8.3
6.4
13
16
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.3
6.4
52
247
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
18.3
6.3
9
5
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
6.3
74
405
D46.0
ICD-10 Finland
Refractory anaemia without ring sideroblasts, so stated
+∞
6.3
6
*
L01BB05
ATC
fludarabine; systemic
27.1
6.2
8
*
B01AB10
ATC
tinzaparin; parenteral
2.2
6.2
52
249
ZXD05
NOMESCO Finland
Urgent procedure
1.7
6.1
137
914
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.4
6.1
21
63
J01MA02
ATC
ciprofloxacin; systemic
1.7
6.1
181
1304
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.1
6.0
59
301
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
234
98
49.01
307.65
5.7
1.4
—
—
—
0
0
267
175
36.41
307.65
8.6
1.5
0.86
1.55
g/l
12.66
202
156
316
441
22.04
251.27
18.9
3.5
306.75
243.65
u/l
6.60
305
419
311
471
19.42
230.61
18.2
2.3
3.38
1.83
%
23.08
296
423
273
348
18.58
227.64
18.5
2.4
120.47
69.61
e9/l
20.88
230
270
101
18
72.20
183.55
5.2
1.1
—
—
—
0
0
101
18
72.20
183.55
5.1
1.1
—
—
—
0
0
91
26
43.69
148.24
2.9
1.3
—
—
—
0
0
196
270
12.15
147.58
5.0
2.8
10.20
10.27
g/l
0.04
186
249
176
223
12.37
140.42
2.8
1.7
1.89
1.58
g/l
0.42
159
201
112
72
20.42
134.74
1.5
1.5
—
—
—
0
0
117
127
12.12
102.23
2.4
3.7
25.15
37.65
mg/l
0.79
98
99
117
127
12.12
102.23
2.4
3.6
59.36
115.49
mg/l
0.52
98
99
115
124
12.14
100.88
2.3
3.6
71.42
2.65
ratio
—
7
11
89
64
17.11
100.04
6.4
7.0
857.92
138.27
iu/ml
0.90
26
11
165
331
7.32
85.40
3.1
3.0
66.64
66.25
g/l
0.19
158
296
202
574
5.60
70.30
3.2
2.4
2.13
2.33
g/l
5.18
189
536
212
630
5.50
69.93
3.4
2.4
16.07
12.80
umol/l
4.61
195
589
195
554
5.47
67.47
3.2
2.4
31.31
21.86
%
7.04
165
475
66
56
13.65
66.72
1.2
1.2
—
—
—
0
0
100
157
7.92
63.86
2.8
2.1
—
—
—
0
0
357
1738
6.24
61.57
14.8
5.6
55.88
57.97
%
1.74
344
1626
259
989
4.85
60.68
2.6
2.1
4.25
3.15
mg/l
6.31
234
849
358
1766
6.16
60.18
16.3
5.8
30.23
26.92
%
3.26
346
1652
351
1719
5.85
59.07
16.0
5.6
2.44
2.85
%
2.91
339
1600
59
52
12.92
58.06
1.2
1.2
308.07
290.58
u/ml
0.09
30
24
157
426
5.14
56.07
5.4
3.0
12.07
9.33
umol/l
0.76
146
377
89
145
7.42
54.58
2.8
2.1
10.95
9.92
g/l
0.83
84
129
84
136
7.37
51.70
3.1
2.4
1.61
0.72
g/l
0.67
76
119
195
692
4.22
48.12
2.1
1.5
1.91
2.60
g/l
4.69
155
402
360
2004
5.09
46.01
20.2
6.3
19.52
11.60
umol/l
11.77
354
1895
372
2129
5.45
45.68
24.0
8.9
4.29
4.21
e9/l
0.07
344
1873
49
49
11.11
44.13
13.5
1.8
34.06
32.90
pg
1.14
49
49
48
51
10.42
41.38
1.3
1.3
113.40
96.73
u/ml
0.69
16
11
297
1518
3.85
40.91
4.3
2.7
551.28
134.29
ug/l
3.97
281
1389
56
82
7.66
37.36
1.3
1.2
—
—
—
0
0
213
980
3.24
32.66
5.0
2.6
352.24
8896.91
umol/l
5.19
205
836
287
1572
3.31
32.56
2.7
2.0
95.86
94.66
pmol/l
0.15
193
789
142
511
3.61
32.48
7.2
5.4
1.09
1.05
mmol/l
0.74
135
463
325
1920
3.54
32.41
12.5
7.1
1.21
1.21
mmol/l
0.36
289
1652
47
72
7.18
29.97
1.2
1.4
—
—
—
0
0
205
970
3.06
29.19
2.3
1.6
24.79
20.90
nmol/l
1.07
192
818
35
8
47.33
29.13
1.5
1.4
—
—
—
0
0
301
1773
3.14
28.61
10.4
6.1
1.21
1.21
mmol/l
0.27
283
1600
286
1655
3.02
27.74
7.7
4.7
34.57
35.24
g/l
1.15
276
1542
48
88
5.99
25.66
1.6
1.9
—
—
—
0
0
42
69
6.61
25.01
1.4
1.2
64.16
22.83
u/l
1.42
35
61
35
16
23.62
24.73
3.5
1.1
166.03
56.64
mg/l
1.96
30
11
48
92
5.72
24.48
1.6
1.8
—
—
—
0
0
283
1698
2.82
24.41
7.4
2.7
—
—
—
0
0
168
788
2.81
23.27
2.0
1.7
1440.71
1189.64
nmol/l
1.59
136
581
43
78
5.99
23.20
1.2
1.1
—
—
—
0
0
37
61
6.52
21.92
1.4
1.8
—
—
—
0
0
37
61
6.52
21.92
1.4
1.8
—
—
—
0
0
49
108
4.97
21.34
3.2
2.2
—
—
—
0
0
45
93
5.27
21.09
7.0
3.1
0.94
0.92
nmol/l
—
8
70
134
599
2.77
19.91
4.1
3.4
0.83
0.82
mmol/l
0.93
128
564
36
65
5.94
19.46
1.7
2.0
—
—
—
0
0
141
658
2.67
19.15
2.7
1.9
—
—
—
0
0
368
2699
3.06
18.97
7.0
4.2
23.98
12.99
mm/h
10.79
342
2466
382
2862
3.30
18.91
19.0
7.7
83.89
80.27
u/l
0.99
371
2678
82
290
3.24
18.43
2.1
1.7
—
—
—
0
0
172
905
2.46
17.97
7.0
2.4
—
—
—
0
0
319
2242
2.48
16.75
8.3
5.0
7.03
6.75
mmol/l
0.99
299
2101
199
1144
2.33
16.75
5.6
3.4
38.02
32.65
u/l
1.10
194
1094
33
68
5.16
15.46
1.4
1.7
—
—
—
0
0
27
23
12.42
15.27
2.4
2.0
—
—
—
0
0
237
1506
2.22
15.24
3.0
2.3
77.57
77.87
nmol/l
0.06
228
1331
29
54
5.67
15.15
1.4
1.8
—
—
—
0
0
102
460
2.58
14.41
2.3
1.9
—
—
—
0
0
24
39
6.45
14.34
1.3
1.6
—
—
—
0
0
24
39
6.45
14.34
1.3
1.6
—
—
—
0
0
102
463
2.56
14.20
2.2
1.8
—
—
—
0
0
26
25
10.97
13.92
2.2
2.8
34.92
43.17
%
0.69
12
18
88
376
2.67
13.83
2.5
2.3
0.21
0.21
g/l
0.15
80
355
201
1244
2.12
13.29
3.3
3.1
1814.83
1469.05
ng/l
0.52
176
1070
26
50
5.46
13.12
1.9
1.8
—
—
—
0
0
25
27
9.74
12.64
1.2
1.1
—
—
—
0
0
80
344
2.61
12.34
2.0
2.0
344.24
379.49
nmol/l
0.96
74
315
26
53
5.15
12.31
1.3
1.1
2.22
1.56
u/ml
—
9
16
87
391
2.52
12.25
6.8
3.6
0.81
1.96
mmol/l
1.88
73
310
21
35
6.25
12.23
1.3
2.0
—
—
—
0
0
21
35
6.25
12.23
1.3
2.0
—
—
—
0
0
21
35
6.25
12.23
1.3
2.0
—
—
—
0
0
22
40
5.73
11.76
1.5
2.4
—
—
—
0
0
23
44
5.46
11.66
1.5
2.2
—
—
—
0
0
65
259
2.77
11.61
3.2
4.1
1.99
1.79
mmol/l
0.15
51
196
213
1401
1.99
11.43
4.5
3.3
—
—
—
0
0
18
12
15.57
11.40
3.9
2.1
—
—
—
0
0
39
116
3.59
11.38
1.7
1.2
—
—
—
0
0
188
1186
2.01
11.34
4.5
3.4
37.87
121.99
e6/l
0.85
157
924
19
15
13.17
11.24
3.4
2.3
1707.89
1017.67
u/ml
0.79
19
15
33
88
3.97
11.24
1.5
1.3
2.64
1.93
u/ml
—
10
15
26
59
4.62
10.87
1.4
1.8
—
—
—
0
0
261
1866
1.96
10.75
22.2
16.7
1.50
1.31
inr
1.31
80
529
140
813
2.05
10.49
2.9
1.7
3.10
1.36
mg/l
1.24
118
625
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
39
123
3.38
10.41
2.8
2.3
0.29
0.30
u/ml
0.10
23
68
115
622
2.14
10.39
4.1
3.2
2.13
2.36
e6/l
0.15
72
344
173
1094
1.95
10.10
4.3
3.2
0.44
0.47
e6/l
0.05
143
832
25
59
4.43
9.97
1.4
1.1
3.38
3.73
u/ml
—
8
26
21
27
8.10
9.73
1.1
1.0
—
—
—
0
0
219
1510
1.88
9.72
4.7
4.1
33.06
60.30
ng/l
0.67
174
1127
20
41
5.06
9.40
1.9
1.9
—
—
—
0
0
117
660
2.05
9.35
3.7
2.9
1.19
1.08
e6/l
0.15
73
381
198
1335
1.87
9.32
3.7
3.4
2.32
2.35
mmol/l
3.54
176
1163
58
250
2.52
8.81
2.0
1.7
—
—
—
0
0
22
52
4.40
8.76
1.5
1.8
—
—
—
0
0
66
303
2.38
8.75
5.2
3.8
99.90
83.48
ng/l
0.71
56
269
8
0
+∞
8.36
1.1
0.0
—
—
—
0
0
18
38
4.89
8.18
2.3
2.0
—
—
—
0
0
25
70
3.72
7.96
1.5
1.3
56.00
39.81
u/ml
—
7
8
17
24
7.32
7.55
6.6
4.0
—
—
—
0
0
24
68
3.67
7.52
8.5
3.6
54.46
58.93
%
0.64
24
68
133
837
1.84
7.48
3.0
2.6
4.21
4.75
e6/l
0.23
121
759
12
9
13.66
7.42
1.4
1.3
—
—
—
0
0
239
1785
1.73
7.40
5.0
4.0
0.00
0.00
estimate
0.50
55
368
18
29
6.42
7.31
1.2
1.3
—
—
—
0
0
18
42
4.42
7.28
2.6
2.0
—
—
—
0
0
240
1804
1.71
7.18
4.9
4.1
0.06
0.01
estimate
0.39
48
326
18
30
6.21
7.15
1.2
1.2
120.00
38.00
titre
—
6
5
51
230
2.37
7.01
1.4
1.4
—
—
—
0
0
236
1784
1.68
6.77
6.8
5.5
0.00
0.00
estimate
-0.00
49
334
406
3608
2.37
6.70
38.3
15.7
19.55
24.72
mg/l
3.92
358
2875
15
22
7.02
6.57
1.5
1.2
—
—
—
0
0
10
7
14.57
6.42
1.0
1.0
—
—
—
0
0
13
16
8.33
6.37
4.7
4.0
259.77
229.63
u/l
0.46
13
16
6
0
+∞
6.26
1.0
0.0
—
—
—
0
0
6
0
+∞
6.26
1.0
0.0
16.48
—
%
—
6
0
6
0
+∞
6.26
1.0
0.0
9.23
—
%
—
6
0
6
0
+∞
6.26
1.0
0.0
31.97
—
%
—
6
0
18
36
5.16
6.25
1.4
1.8
—
—
—
0
0
13
17
7.84
6.16
1.5
2.4
—
—
—
0
0
13
17
7.84
6.16
1.5
2.4
—
—
—
0
0
13
18
7.40
5.96
1.5
2.3
—
—
—
0
0
10
9
11.33
5.82
1.0
1.6
—
—
—
0
0
37
158
2.46
5.74
1.9
2.2
40.68
39.91
u/l
0.06
32
140
10
10
10.20
5.55
1.6
1.5
—
—
—
0
0
33
136
2.54
5.51
2.6
3.1
—
—
—
0
0
16
43
3.82
5.41
1.0
1.1
—
—
—
0
0
27
102
2.75
5.34
1.5
1.5
0.01
0.14
iu/ml
—
6
23
23
80
2.98
5.27
1.7
1.3
—
—
—
0
0
23
80
2.98
5.27
1.7
1.3
—
—
—
0
0
5
0
+∞
5.22
1.0
0.0
—
—
—
0
0
278
2274
1.59
5.20
4.5
3.2
55.47
48.09
u/l
0.82
257
2101
13
23
5.79
5.10
1.5
2.1
—
—
—
0
0
13
23
5.79
5.10
1.5
2.1
—
—
—
0
0
42
201
2.20
5.05
6.2
3.1
24.29
25.04
mmol/l
0.77
42
196
114
759
1.67
5.03
4.9
3.8
213.43
266.64
ng/l
0.20
95
626
94
594
1.74
5.02
1.3
1.3
54.48
33.99
iu/ml
0.59
34
189
78
467
1.81
5.00
6.9
8.2
0.62
1.11
mmol/l
0.47
57
389
35
161
2.27
4.63
3.0
1.9
—
—
—
0
0
315
2694
1.57
4.51
4.3
3.9
14.87
14.96
pmol/l
0.26
290
2394
406
3714
2.02
4.51
38.1
18.7
139.42
139.65
mmol/l
1.03
399
3610
13
28
4.75
4.40
1.2
1.2
—
—
—
0
0
13
28
4.75
4.40
1.2
1.2
—
—
—
0
0
9
12
7.63
4.37
1.0
1.1
—
—
—
0
0
406
3724
1.98
4.32
40.2
18.8
4.03
3.99
mmol/l
2.03
396
3614
369
3292
1.69
4.31
5.5
4.7
2.04
2.33
mu/l
0.35
343
2942
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
8
9
9.02
4.29
2.1
2.8
158.00
119.22
%
—
8
9
13
29
4.58
4.28
1.2
1.2
—
—
—
0
0
13
29
4.58
4.28
1.2
1.2
—
—
—
0
0
13
29
4.58
4.28
1.2
1.2
—
—
—
0
0
75
465
1.74
4.26
7.2
8.2
11.19
11.85
kpa
0.71
70
449
75
465
1.74
4.26
7.2
8.2
4.62
5.11
kpa
3.98
70
448
112
774
1.60
4.19
3.9
3.1
2.44
2.46
mmol/l
0.79
102
680
17
57
3.06
4.17
1.1
1.1
—
—
—
0
0
61
359
1.81
4.13
2.3
2.6
5.26
6.58
ug/l
0.46
56
319
112
777
1.59
4.12
1.3
1.3
2.83
2.17
u/ml
0.10
29
210
155
1159
1.52
4.07
2.1
2.1
138.17
249.02
u/l
0.99
145
1083
7
7
10.13
4.02
2.0
1.3
79.57
89.29
%
—
7
7
9
14
6.53
4.00
1.7
2.9
105.89
100.43
%
—
9
14
85
556
1.65
3.95
1.2
1.3
15.96
12.56
u/ml
0.10
19
210
8
11
7.38
3.87
1.5
1.4
—
—
—
0
0
6
5
12.14
3.77
1.0
1.0
—
—
—
0
0
117
836
1.54
3.75
1.7
1.7
477.06
449.15
pmol/l
0.37
96
668
410
3806
1.93
3.70
24.8
10.9
26.26
25.26
u/l
0.62
401
3646
39
207
1.97
3.62
7.1
2.6
1.55
1.15
%
1.43
39
207
148
1122
1.48
3.55
3.5
3.3
3969.37
228.16
mg/l
2.77
108
732
6
6
10.11
3.50
1.0
1.3
—
—
—
0
0
23
100
2.37
3.49
1.4
1.4
—
—
—
0
0
344
3069
1.52
3.46
47.5
18.9
15.96
15.14
%
2.21
344
3029
12
34
3.60
3.22
1.6
1.2
—
—
—
0
0
132
995
1.46
3.22
5.5
4.3
0.00
0.01
estimate
0.50
47
331
22
98
2.31
3.18
1.5
1.4
—
—
—
0
0
16
61
2.68
3.17
1.3
1.3
—
—
—
0
0
11
31
3.61
3.01
2.3
1.9
—
—
—
0
0
9
21
4.35
3.01
1.9
1.3
—
—
—
0
0
9
21
4.35
3.01
1.9
1.3
—
—
—
0
0
5
5
10.09
2.98
1.2
1.2
—
—
—
0
0
22
101
2.24
2.98
1.5
1.6
—
—
—
0
0
8
17
4.77
2.93
1.1
1.5
—
—
—
0
0
9
22
4.15
2.89
1.0
1.1
—
—
—
0
0
238
2021
1.38
2.86
3.1
2.8
—
—
—
0
0
365
3340
1.51
2.84
33.3
14.9
74.65
76.73
ml/min/173m2
0.92
327
2746
48
295
1.70
2.83
3.5
2.9
54.04
61.33
ml/min/173m2
0.77
26
120
12
40
3.05
2.71
1.3
2.3
—
—
—
0
0
148
1182
1.38
2.53
3.6
3.1
6.76
7.23
mmol/l
0.72
125
980
9
26
3.51
2.49
1.1
1.1
—
94.40
—
0
5
28
152
1.90
2.49
2.6
1.7
—
—
—
0
0
8
21
3.86
2.47
2.1
2.0
—
—
—
0
0
8
21
3.86
2.47
2.1
2.0
—
—
—
0
0
148
1190
1.36
2.40
5.0
3.8
16.36
9.84
mg/mmol
0.70
102
749
17
77
2.26
2.40
1.2
1.3
358.33
228.09
miu/ml
—
6
35
9
27
3.38
2.40
2.0
1.9
—
—
—
0
0
65
451
1.52
2.36
4.0
4.3
3.23
39.98
ug/l
1.33
60
381
8
23
3.52
2.28
1.4
1.7
91.38
80.00
umol/l
—
8
23
169
1404
1.33
2.17
5.8
4.2
—
—
—
0
0
20
103
1.99
2.08
1.5
1.7
—
—
—
0
0
412
3933
1.61
1.97
60.0
23.0
231.19
246.10
e9/l
2.97
403
3836
412
3936
1.60
1.93
59.7
23.0
3.90
4.45
e12/l
39.26
403
3823
412
3936
1.60
1.93
59.3
23.1
35.89
39.80
%
24.31
386
3667
32
197
1.67
1.92
1.3
1.2
297.62
194.27
u/ml
0.32
21
177
104
817
1.36
1.92
5.0
4.3
1.02
1.02
kg/l
0.09
17
117
12
52
2.34
1.89
1.0
1.0
—
—
—
0
0
7
22
3.22
1.88
1.3
1.1
—
—
—
0
0
15
72
2.12
1.88
2.0
1.5
—
—
—
0
0
9
35
2.60
1.81
1.0
1.1
—
—
—
0
0
7
23
3.08
1.80
1.0
1.4
—
—
—
0
0
7
23
3.08
1.80
1.0
1.4
—
—
—
0
0
6
18
3.36
1.75
2.2
1.3
—
—
—
0
0
6
18
3.36
1.75
2.2
1.3
—
—
—
0
0
6
18
3.36
1.75
1.7
1.5
0.99
0.97
g/l
—
6
18
15
75
2.03
1.71
3.0
2.7
16.11
15.80
%
—
9
40
6
19
3.19
1.66
1.2
1.1
44.00
39.46
u/l
—
6
19
6
19
3.19
1.66
1.2
1.1
120.50
112.58
u/l
—
6
19
19
105
1.85
1.65
1.3
1.3
—
—
—
0
0
5
15
3.36
1.52
1.0
1.2
98.56
174.52
iu/ml
—
5
15
23
139
1.69
1.51
2.7
2.0
612.83
552.58
ug/l
0.04
23
129
12
59
2.06
1.44
1.8
2.9
4.09
4.05
mmol/l
0.13
12
59
12
59
2.06
1.44
1.8
2.9
103.75
105.78
mmol/l
0.80
12
59
11
53
2.10
1.39
1.8
1.6
—
—
—
0
0
11
53
2.10
1.39
1.8
1.6
—
—
—
0
0
19
112
1.73
1.37
1.4
1.2
—
—
—
0
0
52
387
1.39
1.36
5.2
3.6
—
—
—
0
0
11
54
2.06
1.34
1.8
1.6
—
—
—
0
0
11
54
2.06
1.34
1.8
1.6
—
—
—
0
0
11
54
2.06
1.34
1.8
1.6
—
—
—
0
0
11
54
2.06
1.34
1.8
1.6
—
—
—
0
0
10
49
2.06
1.23
1.3
1.1
—
—
—
0
0
19
118
1.64
1.16
1.6
1.5
—
—
—
0
0
13
72
1.83
1.16
11.9
2.3
65.93
60.97
%
0.25
13
72
5
20
2.52
1.15
1.4
1.2
—
—
—
0
0
10
51
1.98
1.12
10.1
6.6
14.80
11.95
mg/l
—
10
46
13
73
1.80
1.12
1.5
1.6
3.83
4.62
mmol/24h
0.63
13
62
18
112
1.63
1.10
1.4
1.2
—
—
—
0
0
365
3490
1.25
1.04
5.1
4.8
6.19
6.02
mmol/l
1.01
332
3140
7
35
2.02
1.00
1.3
1.1
—
—
—
0
0
7
35
2.02
1.00
1.9
1.3
—
—
—
0
0
13
76
1.73
1.00
2.5
1.6
—
—
—
0
0
59
472
1.29
0.99
11.9
7.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
23
2.19
0.98
1.0
1.3
—
—
—
0
0
24
168
1.45
0.92
1.5
1.3
—
—
—
0
0
8
45
1.79
0.84
1.1
1.1
—
22.10
—
0
10
6
33
1.83
0.79
1.2
1.3
0.28
0.36
nmol/l
—
6
23
0
27
0.00
0.77
0.0
1.9
—
—
—
0
0
9
59
1.54
0.68
1.3
1.2
—
—
—
0
0
7
42
1.68
0.68
2.6
4.7
—
—
—
0
0
15
102
1.49
0.68
1.9
2.4
98.79
83.28
ug/min
—
8
61
88
998
0.85
0.65
4.2
4.6
24.47
21.52
%
0.96
47
503
5
29
1.73
0.64
14.0
2.3
14.80
13.34
%
—
5
29
23
173
1.35
0.63
2.9
2.9
19.53
58.86
u/ml
1.04
23
167
0
21
0.00
0.60
0.0
1.0
—
1.00
—
0
15
62
718
0.84
0.60
3.0
3.1
1.23
0.81
ug/l
0.93
47
486
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
6
38
1.59
0.54
1.3
1.2
44.00
44.52
u/l
—
6
33
16
215
0.73
0.54
1.3
1.8
—
—
—
0
0
50
434
1.17
0.44
1.8
1.4
—
—
—
0
0
19
235
0.80
0.38
1.4
2.0
—
—
—
0
0
5
37
1.36
0.37
1.4
2.1
47.04
4.26
umol/l
—
5
28
6
41
1.47
0.36
1.7
1.9
—
—
—
0
0
6
43
1.40
0.35
1.0
2.5
14.13
6.87
nmol/l
—
6
43
6
45
1.34
0.34
1.3
1.3
0.47
0.59
nmol/l
—
6
40
17
208
0.81
0.32
1.5
1.2
22.05
172.93
iu/ml
—
8
83
341
3470
0.93
0.25
5.0
4.5
1.37
1.47
mmol/l
3.67
310
3139
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
339
3337
1.07
0.21
7.2
6.1
37.89
40.50
mmol/mol
3.86
308
3064
0
14
0.00
0.20
0.0
2.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
100
951
1.07
0.20
1.7
1.6
1.58
1.33
mmol/l
1.55
81
790
353
3575
0.94
0.18
5.5
5.2
2.48
2.67
mmol/l
4.02
322
3242
129
1247
1.05
0.15
4.4
5.3
2.52
2.59
ug/l
0.06
113
1100
21
233
0.90
0.14
1.6
1.7
—
—
—
0
0
10
117
0.85
0.13
1.4
1.7
—
—
—
0
0
50
473
1.06
0.12
4.5
4.7
31.11
32.16
%
0.22
36
300
10
85
1.18
0.12
1.6
1.4
—
—
—
0
0
50
525
0.95
0.11
1.5
1.5
—
—
—
0
0
332
3351
0.96
0.10
4.7
4.1
1.39
1.27
mmol/l
1.52
299
3007
5
44
1.14
0.10
1.2
1.2
—
—
—
0
0
6
72
0.83
0.07
1.3
1.5
—
—
—
0
0
6
74
0.81
0.07
2.0
2.7
45.83
30.28
u/ml
—
6
74
8
95
0.84
0.06
1.0
1.7
—
—
—
0
0
25
263
0.95
0.05
2.2
2.0
11.46
12.92
nmol/l
0.28
20
237
348
3497
0.98
0.05
5.1
4.6
4.34
4.58
mmol/l
3.78
318
3193
18
176
1.02
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
77.83
—
0
6
6
60
1.00
-0.00
2.2
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
1.4
1.5
227.29
334.78
mu/l
—
7
65
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
513.17
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_AIHA_OTHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_AIHA_OTHER | 2.299 [1.91, 2.77] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.982 |
During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 1170 females with D3_AIHA_OTHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_AIHA_OTHER | 2.82 [2.2, 3.62] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 421 out of 976 males with D3_AIHA_OTHER died.
Mortality risk
Mortality risk for people of age
years, who have D3_AIHA_OTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.296% | 0.505% |
| 5 | 1.48% | 3.21% |
| 10 | 3.848% | 8.18% |
| 15 | 7.384% | 13.968% |
| 20 | 13.26% | 22.862% |
Relationships between endpoints
↥Index endpoint: D3_AIHA_OTHER – Other autoimmune haemolytic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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