Haemolytic anaemias

D3_HAEMOLYTICANAEMIA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

1352

6. Filter based on genotype QC (FinnGen only)

1199

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12357 6434 5535
Only index persons 8979 4855 4124
Unadjusted period prevalence (%)
Whole population 0.18 0.18 0.15
Only index persons 0.17 0.18 0.16
Median age at first event (years)
Whole population 51.74 53.46 50.94
Only index persons 47.59 47.37 47.84

-FinnGen-

Key figures

All Female Male
Number of individuals 1199 619 580
Unadjusted period prevalence (%) 0.24 0.22 0.27
Median age at first event (years) 58.40 53.21 63.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1352
Matched controls
13520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
307.7
428
*
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
291.5
269
*
D64.9
ICD-10 Finland
Anaemia, unspecified
7.9
259.6
449
799
XW000
NOMESCO Finland
Bone marrow biopsy
13.0
238.1
248
230
WW500
NOMESCO Finland
Blood transfusion
9.1
154.5
205
261
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.6
125.3
377
1051
TK800
NOMESCO Finland
Hemodialysis
12.1
109.3
113
101
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
11.5
108.6
116
109
L04AA06
ATC
mycophenolic acid; systemic
14.1
108.5
102
78
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
18.8
93.7
75
42
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
10.3
92.7
107
112
Z94.0
ICD-10 Finland
Kidney transplant status
17.2
89.7
75
46
127
Kela drug reimbursment
Transplant complication
13.2
88.8
86
69
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
22.0
84.4
63
30
B03XA02
ATC
darbepoetin alfa; parenteral
9.8
84.3
101
111
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
21.3
83.3
63
31
ZX120
NOMESCO Finland
Intravenous
4.3
82.9
249
678
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.2
80.6
147
261
Z49.1
ICD-10 Finland
Extracorporeal dialysis
14.2
79.8
74
55
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
25.4
79.4
56
23
D58.0
ICD-10 Finland
Hereditary spherocytosis
+∞
73.6
70
*
D58.2
ICD-10 Finland
Other haemoglobinopathies
+∞
73.6
70
*
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
71.5
68
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
14.6
70.2
64
46
A11CC03
ATC
alfacalcidol; systemic
8.1
69.0
96
127
A12AA04
ATC
calcium carbonate; oral
10.5
67.8
76
76
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
15.3
67.7
60
41
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.8
67.3
528
2551
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
12.3
66.5
67
57
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.1
64.1
197
541
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
19.2
63.3
50
27
B03XA01
ATC
erythropoietin; parenteral
14.0
62.5
58
43
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.6
62.0
566
2923
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.8
61.8
151
347
L04AD02
ATC
tacrolimus; systemic
14.1
61.6
57
42
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
17.9
61.2
50
29
D64.8
ICD-10 Finland
Other specified anaemias
8.8
61.0
78
93
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
60.9
58
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
20.7
60.2
46
23
N18.0
ICD-10 Finland
End-stage renal disease
13.5
59.1
56
43
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
58.8
56
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.3
58.5
165
424
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
58.3
746
4472
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
14.2
56.4
52
38
H02AB06
ATC
prednisolone; systemic
2.4
55.8
750
4566
L04AD01
ATC
ciclosporin; systemic
8.9
54.6
69
81
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.6
54.5
201
623
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
8.2
53.6
73
94
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
51.4
49
*
V03AE01
ATC
polystyrene sulfonate; oral
10.0
49.5
57
59
M04AA01
ATC
allopurinol; systemic
3.0
48.7
258
993
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.0
48.4
151
416
TPH04
NOMESCO Finland
Cathetrisation of vein
2.5
48.0
393
1887
C03CA01
ATC
furosemide; systemic
2.3
47.2
521
2854
D56.0
ICD-10 Finland
Alpha thalassaemia
+∞
47.2
45
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
45.5
310
1357
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
9.2
44.8
55
62
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
42.9
41
*
D57.3
ICD-10 Finland
Sickle-cell trait
+∞
41.9
40
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
15.2
41.8
37
25
L04AX01
ATC
azathioprine; systemic
4.8
41.4
98
218
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
6.3
39.9
68
112
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.4
38.9
319
1515
D56.3
ICD-10 Finland
Thalassaemia trait
+∞
38.7
37
*
R50.9
ICD-10 Finland
Fever, unspecified
2.5
38.0
278
1251
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
13.8
37.5
35
26
1XC02, ,
NOMESCO Finland
13.8
37.5
35
26
L04AA01
ATC
[U] ciclosporin
9.6
37.3
44
47
Z49.0
ICD-10 Finland
Preparatory care for dialysis
11.4
37.2
39
35
137
Kela drug reimbursment
Uraemia requiring dialysis
10.8
36.8
40
38
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
5.8
36.2
68
123
UJF32
NOMESCO Finland
Coloscopy
2.2
35.7
408
2220
O99.0
ICD-10 Finland
Anaemia complicating pregnancy, childbirth and the puerperium
11.5
35.5
37
33
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
34.8
208
844
D56.99
ICD-10 Finland
Thalassaemia, unspecified
+∞
34.5
33
*
28200
ICD-8 Finland
Hereditary haemolytic anaemias, Familial acholuric jaundice
+∞
34.5
33
*
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
58.8
34.4
40
7
N08.2*D57.8
ICD-10 Finland
Glomerular disorders in sickle-cell disorders
+∞
33.5
32
*
3AC01, ,
NOMESCO Finland
9.8
33.4
39
41
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.1
33.1
96
250
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.7
32.8
79
178
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
7.6
32.8
47
64
JN4AD
NOMESCO Finland
Body CT examination
2.8
32.7
181
705
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.4
32.4
124
390
H02AB07
ATC
prednisone; oral
2.5
32.3
234
1042
N18.8
ICD-10 Finland
Other chronic renal failure
5.4
32.1
65
126
D70.89
ICD-10 Finland
Neutropenic splenomegaly
8.3
31.7
42
52
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.1
31.4
407
2306
A02BC02
ATC
pantoprazole; systemic
2.0
29.4
916
6961
D56.91
ICD-10 Finland
Thalassemia minor
+∞
29.3
28
*
V03AE02
ATC
sevelamer; oral
28.6
29.0
39
14
D56.1
ICD-10 Finland
Beta thalassaemia
298.1
28.9
29
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.6
28.7
98
286
Z49.2
ICD-10 Finland
Other dialysis
10.6
28.1
31
30
B05DB
ATC
Hypertonic solutions
10.9
27.8
30
28
KA1AE
NOMESCO Finland
Kidney ultrasound examination
4.7
27.5
64
140
Z3231
NOMESCO Finland
Registered nurse
2.0
27.3
427
2567
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
7.8
27.3
38
50
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
+∞
27.2
26
*
ZX108
NOMESCO Finland
Inhalation
9.6
27.1
32
34
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
8.0
26.5
36
46
WW200
NOMESCO Finland
Immunization
4.6
26.1
63
142
2839X
ICD-9 Finland
Acquired haemolytic anaemias, Acquired haemolytic anaemia, unspecified
+∞
26.1
25
*
D50.8
ICD-10 Finland
Other iron deficiency anaemias
6.8
26.0
41
62
WW400
NOMESCO Finland
Plasmaferesis
95.3
25.7
28
*
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
33.8
25.6
33
10
B03BA03
ATC
hydroxocobalamin; parenteral
3.2
25.6
109
365
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
3.9
25.4
77
207
ZXD05
NOMESCO Finland
Urgent procedure
1.9
25.3
451
2818
JN4BD
NOMESCO Finland
Extensive body CT
2.5
24.6
170
735
B05DA
ATC
Isotonic solutions
9.5
24.5
29
31
B01AA03
ATC
warfarin; systemic
2.1
24.5
300
1646
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
88.4
23.7
26
*
Z2221
NOMESCO Finland
Medical doctor
1.9
23.6
399
2442
H02AB04
ATC
methylprednisolone; systemic
2.2
23.5
216
1059
2830A
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA PRIMARIA]
+∞
23.0
22
*
D58.9
ICD-10 Finland
Hereditary haemolytic anaemia, unspecified
+∞
23.0
22
*
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.3
22.3
85
266
GD1AD
NOMESCO Finland
Thorax CT examination
3.0
22.3
105
373
R59.1
ICD-10 Finland
Generalized enlarged lymph nodes
6.1
21.8
38
64
TPX10
NOMESCO Finland
Implantation of vascular injection port
4.0
21.5
63
165
Z31.5
ICD-10 Finland
Genetic counselling
3.1
21.5
94
320
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
6.5
21.4
35
55
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.8
21.3
114
434
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.9
21.2
106
389
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
21.1
321
1887
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
21.1
250
1348
TGC00
NOMESCO Finland
Bronchial lavation
4.2
21.0
57
141
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
5.5
21.0
41
77
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
20.5
224
1172
B82
ICPC
Anaemia other/unspecified
3.8
20.1
61
164
R06.0
ICD-10 Finland
Dyspnoea
1.8
20.0
381
2400
D59.6
ICD-10 Finland
Haemoglobinuria due to haemolysis from other external causes
+∞
19.8
19
*
J01MA12
ATC
levofloxacin; systemic
2.0
19.7
266
1499
ZXE20
NOMESCO Finland
More than three and less than five hours
2.1
19.6
212
1104
6BA02, ,
NOMESCO Finland
26.5
19.2
26
10
H02AB09
ATC
hydrocortisone; systemic
4.0
18.9
54
139
L03AA02
ATC
filgrastim; parenteral
3.8
18.8
57
153
UJF92
NOMESCO Finland
Capsular endoscopy
4.5
18.8
46
105
D55.9
ICD-10 Finland
Anaemia due to enzyme disorder, unspecified
+∞
18.8
18
*
2820A
ICD-9 Finland
Hereditary haemolytic anaemias, Hereditary spherocytosis
+∞
18.8
18
*
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.2
18.8
171
831
R4110
NOMESCO Finland
Physiotherapy
1.8
18.7
383
2457
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.7
18.5
106
418
196
Kela drug reimbursment
Paricalcitol and cinacalcet
16.4
18.4
29
18
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
18.4
358
2263
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
25.4
18.2
25
10
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.0
18.2
85
300
R70.0
ICD-10 Finland
Elevated erythrocyte sedimentation rate
4.2
18.1
49
121
UJF30
NOMESCO Finland
Ileoscopy through colon
2.3
18.0
148
689
ZXE00
NOMESCO Finland
One hour or less
1.7
17.9
529
3745
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.1
17.9
188
965
WX892
NOMESCO Finland
Monitored bed care
2.4
17.9
129
567
D59.2
ICD-10 Finland
Drug-induced nonautoimmune haemolytic anaemia
+∞
17.7
17
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
182.3
17.5
18
*
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
6.6
17.5
28
43
B01AB05
ATC
enoxaparin; parenteral
1.7
17.3
419
2809
B01AB10
ATC
tinzaparin; parenteral
2.2
17.2
151
722
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
17.2
164
811
J01FF01
ATC
clindamycin; systemic
1.8
17.1
357
2295
129
Kela drug reimbursment
Idiopathic thrombocytopaenia or granulocytopenia
26.0
16.9
23
9
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
4.2
16.6
44
107
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
5.2
16.5
34
67
J01MA14
ATC
moxifloxacin; systemic
2.3
16.5
134
621
D47.2
ICD-10 Finland
Monoclonal gammopathy of undetermined significance (MGUS)
5.4
16.4
32
60
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
3.6
16.4
54
154
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
14.5
16.3
27
19
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
13.0
16.2
28
22
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
6.9
16.2
25
37
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
6.7
15.8
25
38
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
15.7
476
3368
D57.1
ICD-10 Finland
Sickle-cell anaemia without crisis
+∞
15.7
15
*
N02AX02
ATC
tramadol; systemic, rectal
1.6
15.3
544
3994
C09AA02
ATC
enalapril; systemic
1.8
15.1
263
1596
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.6
15.1
49
138
A46
ICD-10 Finland
Erysipelas
1.9
15.0
198
1100
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
14.8
249
1495
6753
FHL
Transabdominal splenectomy
57.3
14.8
17
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.1
14.7
142
704
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
18.6
14.7
22
12
C07AB07
ATC
bisoprolol; oral
1.6
14.6
625
4777
WX872
NOMESCO Finland
Intensive care
2.7
14.6
82
320
V03AE03
ATC
lanthanum carbonate; oral
14.3
14.6
24
17
M05BA04
ATC
alendronic acid; oral
2.2
14.5
125
592
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.8
14.4
72
264
JN3AD
NOMESCO Finland
Abdominal CT examination
2.1
14.4
154
794
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
14.4
318
2064
R4190
NOMESCO Finland
Nutritional therapy
2.8
14.4
71
259
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.1
14.3
60
199
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.1
14.3
135
664
Z2446
NOMESCO Finland
Social worker
2.3
14.2
114
525
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
2.4
14.1
100
436
L01AA01
ATC
cyclophosphamide; systemic
14.6
14.1
23
16
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.7
14.0
76
291
E87.5
ICD-10 Finland
Hyperkalaemia
4.1
13.9
38
95
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
13.8
460
3305
A10AB05
ATC
insulin aspart; parenteral
2.3
13.8
114
531
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
13.7
13.7
23
17
K83
ICPC
Heart valve disease NOS
5.8
13.7
25
44
A41.9
ICD-10 Finland
Sepsis, unspecified
3.0
13.7
61
210
SPAT1255
SPAT
Intravenous administration of medicine
2.4
13.6
101
449
C90.0
ICD-10 Finland
Multiple myeloma
5.5
13.6
26
48
D58.1
ICD-10 Finland
Hereditary elliptocytosis
+∞
13.6
13
*
D58.8
ICD-10 Finland
Other specified hereditary haemolytic anaemias
+∞
13.6
13
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
13.5
244
1493
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
3.3
13.5
50
154
V03AC03
ATC
deferasirox; oral
141.4
13.5
14
*
L01AA02
ATC
chlorambucil; oral
16.4
13.5
21
13
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.9
13.4
181
1012
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
3.9
13.4
39
102
A10AC01
ATC
insulin (human); parenteral
2.2
13.2
117
561
WX882
NOMESCO Finland
High dependency care
3.0
13.1
58
199
B81
ICPC
Anaemia vit B12/folate deficiency
2.9
13.1
62
221
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
3.8
13.0
39
104
I50.0
ICD-10 Finland
Congestive heart failure
2.2
13.0
113
537
J01MA02
ATC
ciprofloxacin; systemic
1.6
13.0
487
3586
R59.0
ICD-10 Finland
Localized enlarged lymph nodes
3.1
13.0
55
184
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
13.0
297
1940
J05AB11
ATC
valaciclovir; oral
1.9
12.9
190
1092
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
12.9
235
1441
WX203
NOMESCO Finland
Infraclavicular plexus blockade
3.8
12.8
38
101
K92.1
ICD-10 Finland
Melaena
2.4
12.7
86
367
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
12.7
451
3277
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
70.5
12.6
14
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
3.1
12.5
53
177
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
12.5
12
*
D56.2
ICD-10 Finland
Delta-beta thalassaemia
+∞
12.5
12
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.7
12.5
69
267
A02BC01
ATC
omeprazole; systemic
1.6
12.5
351
2412
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
20.2
12.5
18
9
C08CA01
ATC
amlodipine; oral
1.5
12.5
478
3530
A05AA02
ATC
ursodeoxycholic acid; oral
4.2
12.3
32
77
ZXD10
NOMESCO Finland
Scheduled procedure
1.5
12.2
484
3599
PJA10
NOMESCO Finland
Exploration of lymph nodes
4.7
12.2
28
61
ZX112
NOMESCO Finland
Subcutaneous
3.5
12.1
41
119
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
2.4
12.1
82
350
SPAT1088
SPAT
Blood transfusion
11.2
12.0
22
20
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
21.5
12.0
17
8
H05BX01
ATC
cinacalcet; oral
9.4
12.0
24
26
WX002
NOMESCO Finland
Sedation and analgesia
1.7
11.9
253
1618
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
4.2
11.8
31
75
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
3.8
11.8
35
93
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.7
11.7
65
252
TPH07
NOMESCO Finland
Cathetrisation of artery
1.9
11.7
158
883
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
16.6
11.7
18
11
122
Kela drug reimbursment
Aplastic anaemia
65.5
11.6
13
*
R16.1
ICD-10 Finland
Splenomegaly, not elsewhere classified
23.1
11.6
16
7
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
23.1
11.6
16
7
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
23.1
11.6
16
7
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
8.7
11.5
24
28
C08CA05
ATC
nifedipine; systemic
2.3
11.5
89
403
AA1AD
NOMESCO Finland
CT of head and brain
1.6
11.5
346
2411
28398
ICD-8 Finland
Acquired haemolytic anaemias, Aliae definitar
+∞
11.5
11
*
N02AA05
ATC
oxycodone; systemic
1.7
11.4
230
1447
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.1
11.4
48
160
D72.8
ICD-10 Finland
Other specified disorders of white blood cells
8.4
11.3
24
29
D46.9
ICD-10 Finland
Myelodysplastic syndrome, unspecified
10.6
11.3
21
20
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
35.3
11.3
14
*
S97
ICPC
Chronic ulcer skin
2.3
11.2
88
402
B01AB04
ATC
dalteparin; parenteral
2.4
11.1
74
314
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
11.1
524
4021
N19
ICD-10 Finland
Unspecified kidney failure
2.7
11.1
57
213
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
8.6
11.0
23
27
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.5
11.0
68
278
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.0
11.0
127
672
JN6BD
NOMESCO Finland
Extensive CT of torso and neck
5.8
11.0
20
35
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.0
11.0
126
666
A04AA01
ATC
ondansetron; systemic, rectal
2.1
11.0
107
533
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
10.9
213
1328
321
Kela drug reimbursment
Paricalcitol and cinacalcet
8.3
10.8
23
28
Z99.2
ICD-10 Finland
Dependence on renal dialysis
28.3
10.7
14
5
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
4.1
10.7
29
72
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.1
10.7
103
511
B25.8
ICD-10 Finland
Other cytomegaloviral diseases
13.0
10.7
18
14
D56
ICD-10 Finland
Thalassaemia
110.9
10.4
11
*
D55.0
ICD-10 Finland
Anaemia due to glucose-6-phosphate dehydrogenase [G6PD] deficiency
+∞
10.4
10
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
2.7
10.4
54
203
D64
ICD-10 Finland
Other anaemias
32.8
10.3
13
*
A07AA09
ATC
vancomycin; oral
4.4
10.3
25
57
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
10.7
10.3
19
18
D75.9
ICD-10 Finland
Disease of blood and blood-forming organs, unspecified
8.9
10.3
21
24
JN1BG
NOMESCO Finland
MRI examination of upper part of abodmen with high intensity magnet
5.0
10.3
22
45
R31
ICD-10 Finland
Unspecified haematuria
1.9
10.3
145
821
A12AA12
ATC
[U] calcium acetate
23.6
10.2
14
6
120
Kela drug reimbursment
Hypogammaglobulinaemia
23.6
10.2
14
6
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.2
10.2
83
384
205
Kela drug reimbursment
Chronic hypertension
1.5
10.2
333
2355
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
8.0
10.1
22
28
K29.7
ICD-10 Finland
Gastritis, unspecified
2.7
10.1
54
206
JN6AD
NOMESCO Finland
CT of torso and neck
4.0
10.1
28
71
TK810
NOMESCO Finland
Hemofiltration
9.2
10.0
20
22
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
3.5
9.9
33
95
RS220, ,
NOMESCO Finland
3.9
9.9
28
72
L01XX52
ATC
venetoclax; oral
16.8
9.9
15
9
J06BA01
ATC
immunoglobulins, normal human, for extravascular adm.; systemic
26.2
9.8
13
5
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.4
9.8
70
307
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
2.9
9.8
46
164
107
Kela drug reimbursment
Pernicious anaemia
3.6
9.7
31
87
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.1
9.7
39
127
N08.2*D69.0
ICD-10 Finland
Glomerular disorders in Henoch(-Schönlein) purpura
55.4
9.7
11
*
N18.5
ICD-10 Finland
Chronic kidney disease, stage 5
8.4
9.6
20
24
399
Kela drug reimbursment
Venetoclax
15.1
9.5
15
10
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.3
9.5
72
324
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
9.5
646
5270
TKC20
NOMESCO Finland
Catheterisation of bladder
2.1
9.4
94
472
N08.2*D89.82
ICD-10 Finland
Nepropathy caused by deposition of the light chain of the immunoglobulins
100.7
9.4
10
*
D57.0
ICD-10 Finland
Sickle-cell anaemia with crisis
+∞
9.4
9
*
28299
ICD-8 Finland
Hereditary haemolytic anaemias, Other
+∞
9.4
9
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
2.9
9.3
42
146
C03DA01
ATC
spironolactone; oral
1.8
9.3
160
961
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.8
9.3
157
938
RS221, ,
NOMESCO Finland
3.9
9.3
27
71
J94.8
ICD-10 Finland
Other specified pleural conditions
3.9
9.3
27
71
C09CA06
ATC
candesartan; oral
1.6
9.2
270
1858
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
2.6
9.2
54
216
C01BD01
ATC
amiodarone; systemic
3.0
9.1
40
137
R60.0
ICD-10 Finland
Localized oedema
1.8
9.1
151
898
D45
ICD-10 Finland
Polycythaemia vera
4.8
9.1
20
42
C83.80
ICD-10 Finland
B-cell lymphoma in marginal zone
15.7
9.0
14
9
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
7.1
9.0
21
30
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
9.1
9.0
18
20
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
2.8
9.0
45
166
C07AB02
ATC
metoprolol; systemic
1.6
9.0
255
1742
A10AE04
ATC
insulin glargine; parenteral
1.9
9.0
125
705
C91.9
ICD-10 Finland
Lymphoid leukaemia, unspecified
18.7
8.9
13
7
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.5
8.9
278
1939
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.5
8.9
350
2565
Y84
ICD-10 Finland
Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.7
8.8
20
43
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.0
8.8
38
129
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
8.7
8.8
18
21
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.8
8.7
140
825
I50.1
ICD-10 Finland
Left ventricular failure
2.2
8.7
70
324
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.4
8.6
60
260
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
4.0
8.6
24
61
Z3226
NOMESCO Finland
Physiotherapist
1.6
8.6
232
1566
Z94.4
ICD-10 Finland
Liver transplant status
11.7
8.6
15
13
B80
ICPC
Iron deficiency anaemia
3.0
8.5
37
126
RD210, ,
NOMESCO Finland
3.3
8.5
32
100
V03AE04
ATC
calcium acetate and magnesium carbonate; systemic
27.7
8.5
11
*
D80.9
ICD-10 Finland
Immunodeficiency with predominantly antibody defects, unspecified
27.7
8.5
11
*
D61.9
ICD-10 Finland
Aplastic anaemia, unspecified
27.7
8.5
11
*
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
20.2
8.5
12
6
C83.00
ICD-10 Finland
Lymphocytic lymphoma
20.2
8.5
12
6
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
2.8
8.4
41
149
D73.0
ICD-10 Finland
Hyposplenism
90.6
8.4
9
*
D46.0
ICD-10 Finland
Refractory anaemia without ring sideroblasts, so stated
90.6
8.4
9
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
90.6
8.4
9
*
D83.0
ICD-10 Finland
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
90.6
8.4
9
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.1
8.4
76
368
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
2.3
8.4
60
264
RS222, ,
NOMESCO Finland
4.0
8.4
23
58
R53
ICD-10 Finland
Malaise and fatigue
1.5
8.3
300
2155
2830X
ICD-9 Finland
Acquired haemolytic anaemias, Autoimmune haemolytic anaemias[ANAEMIA HAEMOLYTICA AUTOIMMUNISATORIA NUD]
+∞
8.3
8
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.7
8.3
174
1102
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
2.3
8.3
59
259
C02CA01
ATC
prazosin; oral
3.4
8.2
29
87
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.3
8.2
60
267
A41.8
ICD-10 Finland
Other specified sepsis
3.2
8.1
32
103
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.5
8.1
275
1952
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.4
8.1
52
218
A02BC05
ATC
esomeprazole; systemic
1.4
8.0
467
3671
3025
Kela drug reimbursment
Calcium carbonate
9.0
8.0
16
18
A12BA01
ATC
potassium chloride; oral
2.3
8.0
61
276
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.7
7.9
41
154
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.7
7.9
168
1067
WX402
NOMESCO Finland
General anaesthesia
1.5
7.9
245
1702
104
Kela drug reimbursment
Thyroid insufficiency
2.0
7.9
87
453
B99
ICD-10 Finland
Other and unspecified infectious diseases
3.1
7.9
33
110
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
1.8
7.9
128
757
212
Kela drug reimbursment
Gout
3.3
7.8
29
90
C83.9
ICD-10 Finland
Non-follicular (diffuse) lymphoma, unspecified
10.9
7.8
14
13
K92.0
ICD-10 Finland
Haematemesis
2.8
7.8
37
133
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.3
7.8
58
260
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
3.7
7.8
24
66
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
1.8
7.7
123
722
L04AA05
ATC
[U] tacrolimus
18.5
7.6
11
6
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
18.5
7.6
11
6
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
3.1
7.6
30
97
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.8
7.5
117
682
WZC30
NOMESCO Finland
Teaching
1.6
7.5
184
1213
R80
ICD-10 Finland
Isolated proteinuria
6.5
7.4
18
28
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.5
7.4
245
1726
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
13.4
7.4
12
9
5AB14, ,
NOMESCO Finland
13.4
7.4
12
9
F43.29
ICD-10 Finland
Adaptation disorder UNS
2.9
7.4
33
115
J01DB01
ATC
cefalexin; oral
1.4
7.3
1029
9314
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
1.9
7.3
87
466
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
8.4
7.3
15
18
XG410
NOMESCO Finland
Flow-volume spirometry
2.3
7.3
54
241
D56.8
ICD-10 Finland
Other thalassaemias
+∞
7.3
7
*
N08.2*D65
ICD-10 Finland
Glomerular disorders in disseminated intravascular coagulation [defibrination syndrome]
+∞
7.3
7
*
AC4
HP
MVP
9.4
7.3
14
15
T81.9
ICD-10 Finland
Unspecified complication of procedure
3.2
7.3
28
89
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
4.2
7.3
19
46
L01XX05
ATC
hydroxycarbamide; oral
3.9
7.3
21
55
H03AA01
ATC
levothyroxine sodium; systemic
1.5
7.2
264
1897
C07AG02
ATC
carvedilol; oral
2.0
7.2
79
411
UKC02
NOMESCO Finland
Cystoscopy
1.6
7.2
195
1313
D86.0
ICD-10 Finland
Sarcoidosis of lung
4.0
7.2
20
51
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
7.2
205
1399
J09
ICD-10 Finland
Influenza due to identified zoonotic or pandemic influenza virus
2.6
7.2
39
151
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.0
7.2
71
357
7151
FHL
Kidney transplantation
30.2
7.2
9
*
B02BX05
ATC
eltrombopag; oral
30.2
7.2
9
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.7
7.1
131
802
A07AA02
ATC
nystatin; oral
2.0
7.1
72
365
C91.0
ICD-10 Finland
Acute lymphoblastic leukaemia [ALL]
12.1
7.1
12
10
1518, ,
Kela drug reimbursment
12.1
7.1
12
10
WVA20
NOMESCO Finland
Medicine administration
2.6
7.0
39
153
C02AC05
ATC
moxonidine; oral
2.1
7.0
63
306
A06AD11
ATC
lactulose; oral
1.6
7.0
182
1217
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
7.6
6.9
15
20
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
3.6
6.9
22
62
C08DB01
ATC
diltiazem; oral
2.0
6.8
71
363
J17.3*B59
ICD-10 Finland
Pneumonia due to Pneumocystis carinii
9.4
6.8
13
14
K55.8
ICD-10 Finland
Other vascular disorders of intestine
9.4
6.8
13
14
P01AB01
ATC
metronidazole; oral, rectal
1.4
6.8
446
3560
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
2.2
6.8
53
243
1AA09, ,
NOMESCO Finland
40.3
6.8
8
*
D83.9
ICD-10 Finland
Common variable immunodeficiency, unspecified
40.3
6.8
8
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
16.8
6.7
10
6
L01BB05
ATC
fludarabine; systemic
16.8
6.7
10
6
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
7.2
6.7
15
21
M31.8
ICD-10 Finland
Other specified necrotizing vasculopathies
22.6
6.7
9
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
6.5
6.6
16
25
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
5.5
6.6
18
33
PG1XE
NOMESCO Finland
Other ultrasound examination of blood vessel not elsewhere classified
5.9
6.6
17
29
J01CA04
ATC
amoxicillin; systemic
1.4
6.6
1032
9407
WX202
NOMESCO Finland
Supraclavicular plexus blockade
3.4
6.6
23
69
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.5
6.5
219
1548
TK820
NOMESCO Finland
Peritoneal dialysis
6.2
6.5
16
26
XX9XW, ,
NOMESCO Finland
6.2
6.5
16
26
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.7
6.5
128
799
6112
FHL
Installation of a peritoneal dialysis or lavage catheter in an operating room
70.2
6.4
7
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
3.3
6.4
23
70
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.7
6.4
113
684
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.9
6.4
85
473
XW4XT
NOMESCO Finland
Biopsy of other inner organ with radiological guidance guidance
14.4
6.4
10
7
D68.8
ICD-10 Finland
Other specified coagulation defects
3.8
6.4
19
51
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
1.8
6.3
95
549
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
5.2
6.3
18
35
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
3.2
6.3
24
76
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
5.5
6.3
17
31
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
5.5
6.3
17
31
A04
ICPC
Weakness/tiredness general
1.5
6.3
178
1211
N03AX16
ATC
[U] pregabalin
1.4
6.3
258
1894
C09AA05
ATC
ramipril; oral
1.4
6.3
295
2220
H05BX02
ATC
paricalcitol; systemic
18.1
6.3
9
5
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.9
6.3
81
447
B34.9
ICD-10 Finland
Viral infection, unspecified
2.4
6.3
41
174
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.0
6.3
65
333
D55.2
ICD-10 Finland
Anaemia due to disorders of glycolytic enzymes
+∞
6.3
6
*
4AA25, ,
NOMESCO Finland
+∞
6.3
6
*
28391
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria secundaria
+∞
6.3
6
*
D61.0
ICD-10 Finland
Constitutional aplastic anaemia
+∞
6.3
6
*
AC1
HP
MVR mechanical
26.8
6.2
8
*
2873A
ICD-9 Finland
Purpura and other haemorrhagic conditions, Primary thrombocytopenia[PURPURA THROMBOCYTOPENICA IDIOPATHICA (ITP)]
26.8
6.2
8
*
B28
ICPC
Limited function/disability (B)
7.1
6.2
14
20
C08CA02
ATC
felodipine; oral
1.7
6.2
112
682
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
3.7
6.2
19
52
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
2.8
6.2
29
104
C02EA02, ,
ATC
2.1
6.1
57
280
L03AA13
ATC
pegfilgrastim; parenteral
2.1
6.1
53
254
K76.9
ICD-10 Finland
Liver disease, unspecified
3.6
6.0
19
53
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
10.1
6.0
11
11
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
3.2
6.0
23
73
81
HP
Angiography of the heart and coronary arteries
1.8
6.0
81
453

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
729
1238
11.61
307.65
13.3
2.4
3.11
1.74
%
46.32
692
1103
421
246
24.40
307.65
4.5
1.5
—
—
—
0
0
581
458
21.49
307.65
7.1
1.5
0.89
1.52
g/l
24.80
424
403
611
915
11.36
307.65
12.9
2.4
116.60
68.75
e9/l
28.11
493
704
206
87
27.75
294.32
1.4
1.2
—
—
—
0
0
556
1450
5.81
212.39
4.9
2.5
27.00
22.75
%
5.45
495
1236
575
1551
5.71
211.17
4.6
2.4
2.19
2.34
g/l
6.91
544
1441
599
1679
5.61
210.26
4.7
2.4
14.64
13.00
umol/l
3.95
566
1571
182
157
13.24
181.64
1.5
1.7
—
—
—
0
0
354
834
5.40
146.38
4.8
2.7
10.23
10.50
g/l
0.32
336
762
108
51
22.93
146.12
5.3
2.3
126.35
68.00
mg/l
2.00
98
37
706
2827
4.13
145.58
3.5
2.2
4.05
2.99
mg/l
12.44
632
2413
311
658
5.84
144.99
2.6
1.7
1.63
1.40
g/l
0.73
286
605
136
114
13.15
137.44
1.4
1.3
—
—
—
0
0
74
13
60.16
132.18
1.8
1.4
—
—
—
0
0
200
319
7.18
123.18
3.3
3.5
53.18
73.25
mg/l
0.42
164
256
200
320
7.16
122.81
3.3
3.5
36.01
49.00
mg/l
0.45
164
259
198
314
7.22
122.58
3.2
3.5
45.86
1.72
ratio
0.46
11
29
333
859
4.82
121.86
3.3
2.7
65.83
66.14
g/l
0.24
317
779
294
700
5.09
118.35
3.2
2.3
—
—
—
0
0
943
5097
3.81
114.83
15.2
6.1
—
—
—
0
0
975
5431
3.85
112.25
13.4
5.6
0.04
0.04
e9/l
1.66
887
4683
974
5424
3.85
112.13
13.5
5.6
0.60
0.59
e9/l
0.84
887
4674
989
5576
3.88
111.38
13.5
5.7
2.17
1.95
e9/l
0.89
911
4924
159
223
7.95
109.60
1.9
1.6
—
—
—
0
0
164
240
7.64
108.89
3.3
3.8
—
—
—
0
0
944
5212
3.69
108.76
13.4
5.7
57.42
56.92
%
0.53
910
4898
917
4983
3.61
108.12
14.1
5.8
0.66
0.65
%
0.07
882
4654
937
5162
3.66
108.04
14.7
6.0
8.69
8.61
%
0.32
906
4834
891
4773
3.54
107.14
6.5
2.8
327.64
125.02
ug/l
6.99
848
4386
985
5618
3.78
107.10
14.4
5.9
0.17
0.19
e9/l
5.25
910
4925
931
5134
3.61
106.60
14.3
5.8
2.52
2.87
%
5.24
898
4801
185
317
6.60
105.89
6.2
3.0
3.15
3.59
g/l
2.98
180
298
947
5302
3.62
105.28
14.3
5.8
27.93
28.04
%
0.09
914
4981
432
1496
3.77
104.23
14.3
6.0
1.12
1.07
mmol/l
2.77
414
1383
384
1241
3.93
102.34
2.1
1.6
—
—
—
0
0
154
229
7.46
100.61
1.7
1.5
—
—
—
0
0
150
217
7.65
100.43
1.4
1.4
277.10
233.14
u/ml
0.77
96
121
380
1239
3.88
99.72
5.6
2.8
12.20
8.14
umol/l
2.25
354
1083
120
142
9.18
94.87
10.4
1.8
—
—
—
0
0
951
5538
3.42
94.82
16.2
6.1
18.51
12.45
umol/l
13.19
928
5240
1025
6248
3.65
94.74
19.6
8.6
4.24
4.13
e9/l
0.29
930
5457
101
97
11.17
92.95
1.2
1.3
—
—
—
0
0
282
801
4.18
89.08
1.7
1.5
—
—
—
0
0
188
385
5.51
88.85
3.2
2.1
3.33
3.65
g/l
1.94
178
346
188
386
5.50
88.58
3.2
2.1
6.06
7.46
g/l
18.45
178
346
126
173
7.93
88.09
1.7
1.2
62.20
40.43
u/l
0.68
115
150
180
360
5.61
87.26
3.3
2.2
2.92
3.05
g/l
0.87
170
320
138
212
7.14
87.26
1.7
1.5
116.94
105.07
u/ml
0.85
27
40
108
126
9.23
86.22
9.2
1.9
33.00
32.56
pg
0.36
108
126
425
1667
3.26
81.63
4.5
2.1
30.29
29.87
s
0.54
418
1605
309
1003
3.70
80.03
17.2
7.5
12.37
9.58
mmol/l
4.85
302
951
172
361
5.31
78.78
3.3
2.1
10.25
10.34
g/l
0.07
161
320
166
340
5.43
78.14
9.6
6.8
1.65
1.51
mg/l
1.15
161
313
175
376
5.20
78.02
1.4
1.4
—
—
—
0
0
425
1710
3.17
77.66
2.2
1.7
—
—
—
0
0
809
4610
2.88
77.48
10.0
5.0
34.90
35.42
g/l
1.65
769
4298
550
2562
2.93
77.26
2.1
1.5
22.49
20.71
nmol/l
0.73
500
2164
839
4895
2.88
76.42
14.9
6.4
1.21
1.21
mmol/l
0.67
793
4468
889
5372
2.91
75.27
16.6
7.0
1.21
1.21
mmol/l
2.04
781
4571
157
317
5.47
75.01
3.3
1.5
0.19
0.24
g/l
7.96
143
301
159
328
5.36
74.14
3.2
1.5
1.00
1.20
g/l
11.11
151
309
417
1727
3.05
71.67
5.9
3.7
0.82
0.82
mmol/l
0.17
399
1612
172
396
4.83
70.45
6.1
2.4
22.55
21.47
s
1.78
162
352
553
2689
2.79
70.21
4.8
2.7
368.84
7123.73
umol/l
9.81
506
2345
457
2056
2.85
66.77
2.1
1.7
1357.27
1191.16
nmol/l
2.26
375
1557
603
3130
2.67
66.41
11.3
3.9
7.40
7.40
ph
0.34
104
601
754
4364
2.65
66.37
2.7
2.0
93.93
94.95
pmol/l
0.23
469
2248
262
877
3.47
63.66
7.7
4.2
0.77
0.96
%
0.82
165
299
143
310
5.04
62.74
3.5
2.0
38.42
37.50
g/l
0.89
132
270
540
2723
2.64
62.17
14.7
6.6
—
—
—
0
0
342
1367
3.01
61.50
1.6
1.3
585.12
446.10
titre
0.73
86
282
446
2054
2.75
61.49
2.2
1.9
—
—
—
0
0
243
799
3.49
60.53
7.0
4.1
0.62
0.62
%
0.00
149
256
534
2735
2.57
58.84
9.3
4.0
85.27
88.40
%
1.74
527
2668
246
840
3.36
57.53
8.6
4.0
124.52
84.55
ng/l
4.95
215
741
620
3447
2.48
56.78
6.9
2.4
—
—
—
0
0
451
2215
2.55
53.31
2.0
1.4
2.11
2.39
g/l
2.47
316
1328
236
831
3.23
52.17
8.0
4.3
0.07
0.12
%
0.71
138
253
45
30
15.48
51.28
5.6
4.7
—
—
—
0
0
72
100
7.55
49.50
3.6
2.4
1.10
1.25
e9/l
0.54
67
89
763
4866
2.30
48.50
22.4
9.5
0.08
0.00
e9/l
0.64
646
3962
277
1113
2.87
48.27
10.8
4.3
1.15
1.93
mmol/l
3.19
236
882
76
117
6.82
47.59
1.2
1.2
—
—
—
0
0
101
205
5.24
47.58
1.4
1.2
—
—
—
0
0
276
1125
2.83
46.70
10.9
4.3
5.71
5.84
kpa
1.40
269
1080
78
126
6.51
46.65
2.4
2.4
—
—
—
0
0
541
3026
2.31
46.57
7.4
4.3
—
—
—
0
0
219
789
3.12
46.26
7.8
4.4
0.06
0.58
%
0.67
118
212
581
3359
2.28
46.10
6.0
3.4
37.05
93.65
e6/l
1.79
476
2629
151
432
3.81
45.85
1.4
1.5
1.48
10.95
u/ml
—
5
13
44
36
12.60
44.59
3.3
2.6
—
—
—
0
0
780
5131
2.23
44.50
6.6
2.6
—
—
—
0
0
541
3073
2.27
44.40
5.7
3.3
0.54
0.49
e6/l
0.11
437
2381
484
2635
2.30
43.87
6.4
2.3
—
—
—
0
0
525
2965
2.26
43.49
5.6
3.2
—
—
—
0
0
1081
8204
2.58
43.34
16.9
7.2
83.02
80.47
u/l
1.04
1047
7691
229
884
2.91
42.60
1.7
1.4
—
—
—
0
0
46
45
10.55
41.50
2.3
1.8
—
—
—
0
0
246
1005
2.77
41.05
3.3
2.4
0.21
0.21
g/l
0.32
230
938
631
3908
2.15
40.78
7.1
3.9
74.49
110.62
e6/l
0.71
486
2802
897
6391
2.20
39.92
10.0
5.0
6.83
6.69
mmol/l
0.87
846
5953
55
75
7.60
38.36
3.9
2.5
0.16
0.21
e9/l
1.26
50
65
744
4985
2.10
38.21
28.2
15.5
1.43
1.27
inr
2.91
214
1471
237
990
2.69
37.65
16.4
8.7
—
—
—
0
0
77
152
5.31
37.34
1.5
1.2
4.47
6.31
u/ml
0.34
40
68
352
1776
2.33
37.20
4.7
3.1
2.24
2.45
e6/l
0.21
215
1022
55
78
7.31
37.06
3.9
2.5
571.24
563.08
e6/l
0.03
49
65
669
4373
2.05
36.02
3.3
2.3
74.37
76.75
nmol/l
1.37
625
3897
415
2280
2.18
35.41
5.3
3.0
513.25
547.60
mosm/kgh2o
2.93
366
1962
39
38
10.54
35.23
1.1
1.2
—
—
—
0
0
42
47
9.19
34.34
1.2
1.1
—
—
—
0
0
104
281
3.93
34.06
1.4
1.2
100.00
64.58
titre
0.60
13
24
419
2360
2.12
33.17
4.7
2.6
4.85
5.77
e6/l
0.75
382
2120
354
1867
2.21
33.14
4.4
2.9
1.14
1.22
e6/l
0.12
219
1103
512
3126
2.03
32.42
4.6
3.1
1883.44
1491.76
ng/l
1.10
450
2680
221
956
2.57
32.41
8.9
3.8
5.23
4.64
kpa
2.11
216
916
312
1583
2.26
31.98
2.4
2.0
—
—
—
0
0
551
3471
1.99
31.78
5.7
3.3
36.09
33.08
u/l
1.29
534
3290
414
2355
2.09
31.69
4.6
1.8
2.44
1.31
mg/l
1.74
336
1803
77
176
4.58
31.41
1.1
1.1
—
—
—
0
0
55
95
5.99
30.72
1.8
2.3
—
—
—
0
0
62
121
5.32
30.42
6.5
4.1
—
—
—
0
0
77
182
4.43
30.12
1.1
1.1
—
—
—
0
0
562
3648
1.93
28.98
4.4
3.3
2.33
2.35
mmol/l
4.73
499
3211
41
56
7.52
28.52
2.9
2.4
1524.85
1276.46
u/ml
0.20
41
56
36
42
8.78
28.48
2.0
1.7
—
—
—
0
0
48
80
6.18
27.78
1.2
1.1
89.23
102.50
titre
0.18
13
16
995
7911
1.98
26.27
6.2
4.0
18.80
12.25
mm/h
16.80
935
7276
29
31
9.54
24.47
1.1
1.1
—
—
—
0
0
41
67
6.28
24.18
2.2
1.6
14.32
13.22
umol/l
0.26
41
62
29
32
9.24
23.90
1.0
1.0
—
—
—
0
0
251
1302
2.14
23.69
2.0
1.7
—
—
—
0
0
949
7565
1.85
23.09
7.2
4.3
—
—
—
0
0
28
31
9.20
23.01
1.1
1.2
—
—
—
0
0
204
987
2.26
22.85
3.7
2.4
41.22
87.29
u/l
0.46
184
836
41
71
5.92
22.83
3.1
2.9
33.76
39.30
%
0.68
17
40
63
158
4.13
22.81
2.3
1.7
0.81
0.89
g/l
0.16
52
121
499
3313
1.80
22.50
3.7
2.5
64.93
84.40
u/l
0.37
484
3066
27
30
9.16
22.13
1.9
1.8
—
—
—
0
0
239
1252
2.10
21.85
10.5
8.1
4.98
5.10
kpa
1.08
230
1198
239
1253
2.10
21.80
10.5
8.0
12.00
12.15
kpa
0.18
228
1200
31
14
22.63
21.75
8.8
9.5
6.29
6.07
mmol/l
0.07
31
14
238
1247
2.10
21.74
10.6
8.1
0.95
1.26
mmol/l
0.60
188
987
202
1008
2.18
20.87
2.5
2.1
343.96
368.33
nmol/l
1.03
187
922
102
370
2.90
20.82
1.4
1.2
0.86
1.22
u/ml
—
5
26
906
7245
1.76
20.38
6.6
4.5
670.88
2903.52
e6/l
1.21
16
104
177
848
2.25
20.19
6.9
4.6
5.08
5.14
kpa
0.46
169
816
79
252
3.27
20.10
9.3
3.7
—
—
—
0
0
30
43
7.11
19.98
4.7
2.8
242.43
207.23
u/l
1.15
30
43
175
838
2.25
19.98
7.1
4.7
7.42
7.40
ph
1.03
19
90
35
61
5.86
19.36
1.5
1.7
—
—
—
0
0
76
243
3.25
19.26
5.4
3.3
0.90
0.85
nmol/l
0.23
30
196
38
74
5.25
18.70
1.1
1.1
—
—
—
0
0
449
3040
1.71
18.02
5.0
3.3
1826.56
274.62
mg/l
3.25
347
1966
89
327
2.84
17.74
3.8
3.1
—
—
—
0
0
331
2063
1.80
17.71
5.1
3.9
212.75
367.17
ng/l
1.26
273
1622
106
428
2.60
17.60
3.2
2.0
4.62
2.02
ug/l
0.48
97
375
209
1127
2.01
17.41
11.4
8.4
95.75
95.67
%
0.08
201
1089
74
254
3.02
16.66
1.3
1.2
3.69
8.84
u/ml
0.56
15
42
76
268
2.95
16.32
1.3
1.2
59.87
14.58
u/ml
—
7
12
694
5356
1.61
16.10
5.5
3.7
0.00
0.00
estimate
0.50
158
1110
317
2000
1.76
16.08
3.5
3.0
2.44
2.45
mmol/l
1.05
276
1753
191
1028
2.00
15.93
11.8
8.8
107.52
120.84
g/l
13.28
186
1003
476
3364
1.64
15.76
5.3
3.3
6.76
7.56
mmol/l
4.36
424
2824
697
5404
1.60
15.72
5.5
3.7
0.02
0.00
estimate
0.40
146
1005
100
415
2.52
15.69
5.2
4.1
0.51
0.30
g/l
0.98
59
185
691
5348
1.60
15.69
7.6
5.0
0.00
0.00
estimate
0.50
152
1046
41
100
4.20
15.43
1.6
1.3
—
—
—
0
0
62
201
3.18
15.39
1.3
1.2
40.00
26.31
u/ml
0.32
11
16
455
3196
1.64
15.35
2.6
2.1
197.00
238.04
u/l
0.32
431
3000
71
252
2.92
15.08
1.3
1.2
2.57
2.45
u/ml
—
7
27
40
98
4.18
14.97
1.6
1.3
8.20
6.78
g/l
0.47
29
71
40
98
4.18
14.97
1.6
1.3
0.40
0.39
g/l
0.04
28
70
40
98
4.18
14.97
1.6
1.3
2.49
2.59
g/l
0.10
30
70
371
2487
1.68
14.95
4.4
3.7
—
—
—
0
0
46
127
3.71
14.62
1.2
1.2
—
—
—
0
0
238
1419
1.82
14.47
1.4
1.2
—
—
—
0
0
1200
10797
1.99
14.43
34.7
14.3
20.51
24.58
mg/l
6.53
1072
8561
63
215
3.02
14.35
6.1
3.6
57.73
58.67
%
0.19
63
215
24
39
6.25
14.23
4.0
3.4
172.94
362.86
e6/l
0.97
17
21
40
103
3.97
14.02
2.3
1.3
76.80
35.33
iu/ml
—
5
6
573
4324
1.56
13.96
5.0
3.4
5.90
5.84
ph
0.15
20
306
168
906
1.98
13.86
2.3
2.5
11.06
6.95
ug/l
0.66
149
795
449
3213
1.60
13.71
6.0
3.9
23.91
9.05
mg/mmol
3.72
339
2038
471
3410
1.59
13.68
3.9
3.1
—
—
—
0
0
169
918
1.96
13.65
4.4
3.0
328.15
215.91
ng/l
1.90
155
846
26
26
10.17
13.49
1.2
2.0
—
—
—
0
0
35
87
4.10
12.87
1.2
1.1
—
—
—
0
0
539
4066
1.54
12.85
5.2
3.7
46.99
49.99
ng/l
0.09
415
2839
126
638
2.08
12.35
7.8
4.9
—
—
—
0
0
33
81
4.15
12.35
1.6
1.3
—
—
—
0
0
28
61
4.67
12.15
1.1
1.0
—
—
—
0
0
108
523
2.16
11.89
2.8
2.4
—
—
—
0
0
424
3084
1.55
11.68
1.7
1.5
—
—
—
0
0
36
99
3.71
11.55
8.0
4.0
10.51
11.23
%
0.47
36
99
51
176
2.97
11.43
1.6
1.4
—
—
—
0
0
827
6927
1.50
11.42
5.1
3.1
51.82
48.44
u/l
0.62
784
6450
538
4136
1.50
11.34
2.5
2.1
—
—
—
0
0
118
604
2.04
11.23
12.9
11.2
—
—
—
0
0
52
187
2.85
10.84
6.1
2.9
—
—
—
0
0
111
567
2.04
10.63
7.2
5.2
24.16
24.67
mmol/l
1.01
105
537
134
735
1.91
10.47
7.1
5.5
—
—
—
0
0
37
111
3.40
10.45
3.2
2.6
0.70
1.39
g/24h
1.54
20
55
23
30
7.78
10.40
1.4
1.1
—
—
—
0
0
15
8
18.94
10.27
1.1
1.1
—
—
—
0
0
257
1717
1.61
10.03
1.3
1.3
39.52
31.08
iu/ml
0.46
77
545
74
330
2.31
9.96
1.2
1.4
363.84
235.60
miu/ml
1.09
23
154
112
594
1.97
9.66
1.3
1.2
—
—
—
0
0
24
56
4.35
9.60
1.1
1.0
—
—
—
0
0
17
16
10.74
9.29
1.3
1.4
—
—
—
0
0
21
29
7.34
9.23
1.2
1.2
—
—
—
0
0
1192
11011
1.70
8.99
38.4
16.8
139.11
139.60
mmol/l
8.96
1174
10710
322
2319
1.51
8.91
1.9
1.7
454.24
32565873.50
pmol/l
2.39
265
1910
57
238
2.46
8.90
6.0
3.9
—
—
—
0
0
1193
11039
1.69
8.73
39.9
16.9
4.01
3.98
mmol/l
2.85
1170
10713
75
357
2.17
8.66
1.7
1.7
—
—
—
0
0
53
220
2.47
8.39
4.0
2.4
15.53
16.12
%
0.39
30
118
932
8212
1.43
8.37
4.4
3.9
14.83
14.82
pmol/l
0.01
852
7419
123
707
1.81
8.30
2.7
2.7
4.53
6.44
e9/l
1.09
100
576
11
5
22.16
8.02
1.1
1.0
—
—
—
0
0
141
860
1.71
7.76
9.1
3.9
1.22
1.23
mmol/l
0.28
129
743
26
76
3.47
7.69
6.2
3.1
—
—
—
0
0
48
200
2.45
7.57
1.6
1.3
—
—
—
0
0
166
1071
1.63
7.37
3.7
4.1
7.76
25.38
ug/l
1.20
142
880
7
0
+∞
7.30
4.4
0.0
—
—
—
0
0
186
1239
1.58
7.23
1.8
1.4
—
—
—
0
0
841
7368
1.37
7.19
4.9
3.8
—
—
—
0
0
17
38
4.52
7.19
1.2
1.0
—
—
—
0
0
53
239
2.27
7.02
2.9
2.1
120.79
129.57
g/l
1.15
38
184
117
700
1.74
6.90
10.7
7.6
24.17
24.51
mmol/l
0.41
111
669
32
114
2.85
6.87
1.6
1.3
40068.60
132175.16
e6/l
0.73
20
68
232
1642
1.50
6.83
1.3
1.2
31.94
11.29
u/ml
0.38
76
619
65
326
2.04
6.61
1.2
1.2
—
—
—
0
0
47
207
2.32
6.59
7.2
2.8
—
—
—
0
0
171
1141
1.57
6.59
1.4
1.3
—
—
—
0
0
37
146
2.58
6.56
2.6
2.7
—
—
—
0
0
1208
11361
1.59
6.50
22.1
10.1
26.10
26.07
u/l
0.02
1186
10934
41
171
2.44
6.49
2.2
2.9
—
—
—
0
0
75
401
1.92
6.38
3.9
3.4
662.03
3608.67
u/ml
0.61
67
343
84
467
1.85
6.34
8.4
6.2
2.18
1.58
%
4.54
78
441
325
2485
1.41
6.31
1.3
1.3
1.93
1.90
u/ml
0.01
62
646
32
120
2.71
6.27
6.2
3.0
—
—
—
0
0
15
24
6.31
6.17
1.6
1.4
—
—
—
0
0
83
465
1.84
6.13
8.4
6.2
0.94
0.91
%
0.24
77
441
1069
9842
1.41
6.11
5.4
4.6
2.01
2.04
mu/l
0.09
998
8968
15
25
6.05
6.00
3.4
1.4
—
—
—
0
0
33
129
2.60
5.98
1.6
1.3
800.13
1662.77
e6/l
1.69
23
91
50
237
2.15
5.92
8.1
4.9
3.15
2.68
mmol/l
0.45
34
162
24
80
3.04
5.82
1.4
1.2
—
—
—
0
0
30
114
2.67
5.76
1.2
1.1
—
—
—
0
0
165
1129
1.53
5.68
1.6
1.7
—
—
—
0
0
17
37
4.64
5.49
2.5
1.4
—
—
—
0
0
52
260
2.04
5.38
3.0
2.3
121.33
108.85
ug/min
0.09
38
152
16
43
3.75
5.37
1.9
1.3
—
—
—
0
0
41
187
2.23
5.35
1.5
1.3
60.83
65.89
mmol/l
0.34
29
152
23
79
2.94
5.31
1.2
1.1
—
—
—
0
0
364
2905
1.35
5.31
6.1
3.9
0.01
0.01
estimate
0.25
140
1019
30
120
2.53
5.23
1.5
1.5
—
—
—
0
0
19
59
3.25
5.18
1.1
1.1
1.06
1.07
ratio
—
6
21
33
139
2.41
5.17
1.7
1.6
—
—
—
0
0
131
871
1.56
5.14
3.8
3.3
—
—
—
0
0
145
1006
1.49
4.68
6.3
4.1
—
—
—
0
0
28
115
2.47
4.65
1.1
1.1
—
—
—
0
0
28
115
2.47
4.65
1.6
1.4
—
—
—
0
0
79
475
1.70
4.65
2.5
1.8
—
—
—
0
0
9
11
8.23
4.56
2.1
1.9
1.36
1.21
umol/l
—
9
11
181
1319
1.43
4.54
3.1
2.3
150.61
122.58
ug/g
0.69
144
1037
371
3029
1.31
4.52
5.1
3.9
—
—
—
0
0
63
360
1.79
4.43
9.5
7.6
1.25
1.28
mmol/l
0.10
51
316
45
231
1.98
4.39
2.6
1.7
1.21
0.86
nmol/l
2.18
36
190
56
311
1.84
4.33
1.4
1.5
263.41
288.07
ug/g
0.47
43
183
1183
11250
1.41
4.24
32.4
13.6
—
—
—
0
0
59
336
1.79
4.21
1.3
1.2
—
—
—
0
0
9
13
6.96
4.16
2.3
3.3
—
—
—
0
0
94
611
1.58
4.10
3.2
3.2
4.29
4.60
pmol/l
1.72
82
537
14
42
3.36
4.05
1.5
1.4
—
—
—
0
0
11
22
5.03
4.00
1.5
1.6
—
—
—
0
0
55
915
0.58
3.80
1.2
1.3
—
—
—
0
0
11
24
4.61
3.74
3.6
3.3
—
—
—
0
0
11
24
4.61
3.74
1.7
1.8
—
—
—
0
0
49
274
1.82
3.74
3.4
2.5
—
—
—
0
0
28
128
2.21
3.72
2.3
1.4
55.06
46.95
mu/l
0.19
22
114
10
20
5.03
3.69
2.1
1.3
—
—
—
0
0
175
1322
1.37
3.57
1.4
1.3
—
—
—
0
0
37
193
1.94
3.50
1.4
1.6
—
—
—
0
0
8
13
6.18
3.50
1.5
1.8
—
—
—
0
0
22
93
2.39
3.49
3.4
3.4
157.49
28.73
mg/l
1.21
17
70
27
125
2.18
3.49
1.4
1.7
69.13
61.68
%
0.55
21
90
12
31
3.90
3.49
2.3
1.9
—
—
—
0
0
31
152
2.06
3.48
1.2
1.2
—
—
—
0
0
293
2394
1.29
3.46
5.3
3.9
1.02
1.02
kg/l
0.46
39
348
99
682
1.49
3.36
1.6
1.3
164.91
229.52
u/ml
0.62
84
627
20
84
2.40
3.23
1.1
1.0
300.80
290.09
mg/l
0.20
20
74
23
103
2.25
3.23
1.7
1.3
—
—
—
0
0
7
11
6.39
3.18
3.3
3.1
—
—
—
0
0
52
314
1.68
3.10
1.5
1.5
10.35
9.15
u/l
0.27
42
256
43
246
1.77
3.10
1.5
1.4
—
—
—
0
0
303
3592
0.80
2.99
3.5
2.8
—
—
—
0
0
43
251
1.74
2.91
1.6
1.5
—
—
—
0
0
42
245
1.74
2.85
1.5
1.4
—
—
—
0
0
22
104
2.13
2.75
1.2
1.1
—
—
—
0
0
5
6
8.36
2.75
1.0
1.8
—
—
—
0
0
80
553
1.47
2.72
6.5
3.8
—
—
—
0
0
26
132
1.99
2.71
1.6
1.5
0.28
0.34
nmol/l
0.40
21
108
24
119
2.04
2.67
1.3
1.4
400.32
332.89
pmol/l
0.51
19
106
13
49
2.67
2.62
1.3
1.3
169.46
176.20
mmol/24h
0.06
13
49
43
261
1.67
2.56
12.4
8.7
11.18
11.26
mmol/l
0.04
38
239
43
261
1.67
2.56
12.4
8.7
106.71
105.51
mmol/l
0.86
38
239
12
42
2.87
2.55
2.1
3.3
—
—
—
0
0
342
2950
1.21
2.43
6.2
3.4
—
—
—
0
0
6
12
5.02
2.40
1.2
1.1
—
—
—
0
0
7
17
4.13
2.36
1.3
1.2
—
—
—
0
0
16
71
2.27
2.34
2.4
1.5
0.92
0.97
g/l
0.36
16
71
5
9
5.57
2.21
1.2
1.4
—
—
—
0
0
8
25
3.21
2.09
1.8
2.0
—
—
—
0
0
27
155
1.76
2.01
1.2
1.2
—
—
—
0
0
40
256
1.58
1.99
1.2
1.5
4.11
3.73
mmol/l
1.02
35
240
41
264
1.57
1.99
1.4
1.7
835.97
583.07
e6/l
0.15
31
212
41
264
1.57
1.99
1.3
1.6
2.86
39.44
e6/l
0.97
28
207
22
119
1.86
1.97
2.4
1.7
—
—
—
0
0
5
11
4.56
1.94
5.6
2.7
—
—
—
0
0
59
414
1.44
1.93
1.4
1.4
25.51
24.34
iu/l
0.09
50
352
9
33
2.74
1.93
2.7
1.9
—
—
—
0
0
123
974
1.29
1.89
7.7
3.8
—
—
—
0
0
11
46
2.40
1.85
1.0
1.1
176.89
232.38
iu/ml
0.32
11
46
60
429
1.42
1.79
8.0
4.6
—
—
—
0
0
30
185
1.64
1.76
1.5
1.4
—
—
—
0
0
31
193
1.62
1.75
1.3
1.1
—
—
—
0
0
21
117
1.81
1.75
1.3
1.2
—
—
—
0
0
9
36
2.51
1.74
1.1
1.0
1223.56
1582.47
miu/ml
—
9
36
9
191
0.47
1.73
1.7
1.7
—
—
—
0
0
59
424
1.41
1.72
3.2
2.7
—
—
—
0
0
31
194
1.61
1.72
1.3
1.1
—
—
—
0
0
7
24
2.93
1.72
1.3
1.1
—
—
—
0
0
5
13
3.86
1.71
3.0
2.9
—
—
—
0
0
89
686
1.32
1.69
3.8
3.0
—
—
—
0
0
1233
12049
1.26
1.68
54.6
21.0
122.50
134.81
g/l
83.64
1224
11855
1232
12039
1.26
1.67
54.0
20.9
242.25
248.76
e9/l
1.79
1208
11714
12
55
2.19
1.67
1.0
1.1
0.23
1.51
u/ml
—
7
23
41
594
0.68
1.66
1.1
1.4
—
—
—
0
0
7
25
2.81
1.65
2.3
2.0
—
—
—
0
0
1232
12043
1.26
1.64
53.8
20.8
90.96
90.77
fl
0.30
1223
11854
1232
12044
1.26
1.63
53.7
20.7
30.13
30.24
pg
0.55
1223
11853
1232
12044
1.26
1.63
53.9
20.9
7.64
6.80
e9/l
3.20
1205
11682
1232
12045
1.26
1.62
53.9
20.8
4.15
4.48
e12/l
39.74
1204
11685
6
20
3.01
1.58
1.0
1.2
—
—
—
0
0
1231
12039
1.25
1.58
54.7
21.0
36.83
39.96
%
49.19
1168
11227
14
71
1.98
1.54
1.0
1.3
0.18
4.48
u/ml
—
6
32
83
643
1.31
1.54
1.5
1.2
—
—
—
0
0
24
146
1.66
1.51
2.2
2.6
—
—
—
0
0
11
52
2.12
1.44
1.1
1.2
—
71.50
%
—
0
6
14
73
1.93
1.44
1.3
1.3
—
—
—
0
0
5
16
3.13
1.44
2.2
3.0
—
—
—
0
0
5
16
3.13
1.44
4.4
6.0
—
—
—
0
0
26
165
1.59
1.41
1.3
1.5
—
—
—
0
0
11
53
2.08
1.38
2.4
1.8
—
—
—
0
0
37
256
1.46
1.37
1.5
1.7
25546.63
14796.92
e6/l
0.58
27
192
109
890
1.24
1.36
1.1
1.2
—
—
—
0
0
16
90
1.79
1.33
2.3
2.4
7.99
6.90
mmol/l
—
10
59
12
61
1.98
1.33
3.0
3.6
7.44
7.42
ph
—
5
18
305
2740
1.15
1.30
1.8
1.7
1.45
1.36
mmol/l
0.80
264
2301
5
18
2.78
1.28
1.4
1.0
—
—
—
0
0
5
18
2.78
1.28
1.4
1.0
—
—
—
0
0
5
18
2.78
1.28
1.4
1.0
—
—
—
0
0
26
387
0.67
1.26
1.1
1.1
—
—
—
0
0
60
460
1.32
1.24
1.2
1.2
—
—
—
0
0
9
45
2.01
1.23
9.4
19.9
—
—
—
0
0
5
19
2.64
1.21
1.0
1.1
—
—
—
0
0
33
230
1.45
1.20
1.3
1.7
—
—
—
0
0
13
71
1.84
1.19
1.0
1.2
0.36
0.93
u/ml
—
6
36
15
86
1.75
1.19
2.9
2.1
—
—
—
0
0
11
57
1.94
1.17
3.6
2.5
1990.91
1922.70
ml
0.06
11
50
7
30
2.34
1.12
1.0
1.2
—
10.20
%
—
0
5
8
41
1.96
1.09
2.4
2.7
—
—
—
0
0
990
9591
1.12
1.08
7.1
5.7
37.93
39.84
mmol/mol
5.79
902
8835
7
32
2.19
1.08
1.0
1.8
18.57
14.64
pmol/l
—
7
25
36
480
0.74
0.98
1.8
1.6
—
—
—
0
0
30
215
1.40
0.98
1.2
1.2
—
—
—
0
0
18
116
1.56
0.96
1.4
1.6
—
—
—
0
0
119
1021
1.18
0.95
1.7
1.4
—
—
—
0
0
9
51
1.77
0.94
5.2
8.3
—
—
—
0
0
89
750
1.20
0.88
1.6
1.4
—
—
—
0
0
14
88
1.60
0.84
4.5
2.3
0.38
2.03
u/field
—
8
36
184
2038
0.89
0.79
2.7
3.0
0.81
0.77
ug/l
0.15
134
1338
38
295
1.30
0.79
7.6
4.9
—
—
—
0
0
30
225
1.34
0.78
1.5
1.1
3.88
2.96
u/ml
0.10
20
133
13
82
1.59
0.78
1.0
1.6
0.95
1.18
promille
—
8
65
26
192
1.36
0.75
1.2
1.1
0.96
1.25
u/ml
0.15
13
105
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
5
24
2.09
0.74
1.0
1.1
—
—
—
0
0
5
24
2.09
0.74
1.2
1.1
—
—
—
0
0
9
54
1.67
0.74
1.2
1.2
125.33
150.31
nmol/l
—
9
54
5
25
2.00
0.72
2.2
3.5
—
29.79
—
0
7
10
60
1.67
0.72
2.4
3.1
—
—
—
0
0
18
126
1.43
0.70
1.4
2.1
—
—
—
0
0
96
1100
0.86
0.70
1.4
1.5
—
—
—
0
0
1039
10173
1.09
0.69
4.9
4.5
6.06
5.94
mmol/l
1.57
948
9195
5
27
1.85
0.68
1.2
1.4
0.02
0.74
u/ml
—
5
27
11
69
1.60
0.68
2.4
2.8
—
—
—
0
0
7
42
1.67
0.68
1.3
1.0
—
—
—
0
0
9
59
1.53
0.68
1.3
1.3
—
—
—
0
0
17
119
1.43
0.67
2.5
1.9
—
—
—
0
0
5
29
1.73
0.64
9.6
2.6
9.44
11.21
mg/l
—
5
24
13
87
1.50
0.63
1.2
1.4
35.66
27.29
%
—
8
62
26
199
1.31
0.62
1.2
1.1
10.29
5.31
u/ml
0.47
13
117
8
53
1.51
0.58
1.4
1.1
—
—
—
0
0
15
208
0.72
0.58
1.1
1.2
—
—
—
0
0
8
54
1.48
0.57
1.1
1.2
—
—
—
0
0
6
41
1.47
0.50
2.3
1.6
—
—
—
0
0
10
67
1.50
0.49
3.1
2.0
16.59
3.24
ug/l
—
10
59
10
67
1.50
0.49
1.0
1.2
—
—
—
0
0
7
47
1.49
0.47
1.0
1.1
—
—
—
0
0
7
47
1.49
0.47
1.7
1.8
1.63
5.37
nmol/l
—
7
37
7
50
1.40
0.45
1.1
1.1
—
18.57
—
0
7
1003
9867
1.06
0.45
4.6
3.8
1.35
1.27
mmol/l
1.91
907
8978
48
415
1.16
0.43
2.4
2.3
15257.33
3801.48
u/l
1.05
12
182
8
58
1.38
0.41
1.1
1.4
1.67
1.55
g/l
—
8
58
33
391
0.84
0.41
1.2
1.1
—
—
—
0
0
25
204
1.23
0.40
3.6
2.6
—
—
—
0
0
1043
10305
1.05
0.33
5.0
4.3
4.33
4.59
mmol/l
13.33
965
9518
10
74
1.35
0.32
1.5
1.5
—
—
—
0
0
11
83
1.33
0.32
1.3
1.4
92.55
80.80
umol/l
1.12
11
83
14
112
1.25
0.28
2.1
2.5
—
—
—
0
0
8
63
1.27
0.27
3.4
2.6
—
—
—
0
0
5
71
0.70
0.26
1.6
1.3
183.34
168.46
pmol/l
—
5
71
358
3477
1.04
0.25
4.2
5.0
2.28
2.68
ug/l
0.63
318
3095
14
114
1.23
0.25
1.0
1.1
—
—
—
0
0
15
124
1.21
0.24
1.6
1.2
—
—
—
0
0
30
265
1.14
0.23
1.8
1.9
242.19
5.15
iu/l
0.47
13
88
26
228
1.14
0.22
1.4
1.3
—
—
—
0
0
41
452
0.90
0.22
2.8
1.8
—
—
—
0
0
10
79
1.27
0.22
1.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
17.44
—
0
10
42
460
0.91
0.21
2.8
1.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
42
458
0.91
0.19
2.7
1.9
—
—
—
0
0
7
59
1.19
0.18
2.4
1.3
24.64
5.75
ug/l
—
7
49
14
119
1.18
0.17
1.7
1.2
—
—
nmol/l
—
0
0
39
358
1.09
0.17
2.7
2.0
—
—
—
0
0
42
453
0.92
0.16
2.7
1.9
—
—
—
0
0
23
256
0.90
0.16
1.0
1.1
—
—
—
0
0
83
793
1.05
0.14
2.1
2.2
9.95
12.63
nmol/l
1.87
66
700
76
727
1.05
0.12
1.2
1.2
162.06
139.76
iu/ml
0.13
26
283
11
127
0.87
0.12
1.0
1.0
1.65
0.45
u/ml
—
5
50
1028
10229
1.02
0.11
4.9
4.3
1.38
1.45
mmol/l
6.13
939
9385
14
125
1.12
0.10
1.1
1.4
—
—
—
0
0
5
48
1.04
0.09
1.4
1.3
—
—
—
0
0
6
56
1.07
0.08
1.0
1.0
—
—
—
0
0
6
56
1.07
0.08
1.0
1.0
8.48
7.26
kpa
—
6
40
41
430
0.95
0.08
2.7
1.9
—
—
—
0
0
12
133
0.90
0.07
1.1
1.1
0.83
7.91
u/ml
—
5
56
33
313
1.06
0.07
5.3
2.8
—
—
—
0
0
32
336
0.95
0.07
8.1
11.3
—
—
—
0
0
22
234
0.94
0.06
7.7
3.6
17.46
27.98
mg/l
1.56
13
155
14
150
0.93
0.04
1.1
1.1
2.83
7.48
u/ml
—
8
78
18
190
0.95
0.04
1.1
1.1
0.19
1.63
u/ml
2.46
11
114
1051
10496
1.01
0.02
5.4
4.8
2.49
2.71
mmol/l
13.00
968
9631
118
1184
1.00
0.00
2.0
1.7
—
—
—
0
0
30
299
1.00
0.00
1.5
1.7
46.37
40.02
nmol/l
0.66
30
286
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.0
2.68
3.37
kpa
—
5
39
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.4
—
—
—
0
0
6
64
0.94
-0.00
1.0
1.0
19.17
19.43
mmol/l
—
6
58
0
7
0.00
-0.00
0.0
2.3
—
2.36
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
343.80
—
0
5

Mortality – FinRegistry

Association

Association between endpoint D3_HAEMOLYTICANAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_HAEMOLYTICANAEMIA 2.473 [2.14, 2.85] < 0.001
Birth year 0.991 [0.98, 1.0] 0.033

During the follow-up period (1.1.1998 — 31.12.2019), 1256 out of 4383 females with D3_HAEMOLYTICANAEMIA died.

Males

Parameter HR [95% CI] p-value
D3_HAEMOLYTICANAEMIA 2.749 [2.33, 3.24] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 1102 out of 3793 males with D3_HAEMOLYTICANAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_HAEMOLYTICANAEMIA.

N-year risk Females Males
1 0.245% 0.505%
5 1.307% 3.3%
10 3.425% 7.845%
15 6.329% 14.152%
20 10.539% 23.642%

Relationships between endpoints

Index endpoint: D3_HAEMOLYTICANAEMIA – Haemolytic anaemias

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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