hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Other and unspecified acquired haemolytic anaemias
DOID EFO Endpoint Browser PheWeb
D3_ACQHAEMOLYTICANAEMIANAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
319 |
4. Check minimum number of eventsNone |
319 |
5. Include endpointsNone |
319 |
6. Filter based on genotype QC (FinnGen only) |
319 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified acquired haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3078 | 1682 | 1353 |
| Only index persons | 1978 | 1086 | 892 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 66.16 | 67.62 | 64.26 |
| Only index persons | 61.66 | 62.26 | 60.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 319 | 148 | 171 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.08 |
| Median age at first event (years) | 61.96 | 56.44 | 66.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 295
- Matched controls
- 2948
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
8759.1
277.3
222
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
84.5
77
*
D64.9
ICD-10 Finland
Anaemia, unspecified
11.1
57.7
124
181
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
50.5
47
*
XW000
NOMESCO Finland
Bone marrow biopsy
13.9
34.5
61
54
2839X
ICD-9 Finland
Acquired haemolytic anaemias, Acquired haemolytic anaemia, unspecified
+∞
24.3
23
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.8
22.8
87
238
WW500
NOMESCO Finland
Blood transfusion
9.0
21.6
47
61
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.5
20.6
131
552
ZX120
NOMESCO Finland
Intravenous
5.0
19.3
67
163
H02AB06
ATC
prednisolone; systemic
3.1
19.0
180
994
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
16.8
16
*
R50.9
ICD-10 Finland
Fever, unspecified
3.9
16.3
76
243
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
16.2
130
621
B01AA03
ATC
warfarin; systemic
3.2
16.1
108
454
C03CA01
ATC
furosemide; systemic
2.9
16.0
136
672
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.9
15.5
53
125
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
16.2
15.2
24
16
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
9.7
14.9
30
34
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
11.3
14.6
27
26
L04AX01
ATC
azathioprine; systemic
7.5
14.4
34
50
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
14.3
161
922
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
13.3
54
151
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
12.8
75
282
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
12.6
91
394
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
12.5
105
499
B03XA02
ATC
darbepoetin alfa; parenteral
11.2
12.0
22
21
UJF32
NOMESCO Finland
Coloscopy
2.7
11.8
103
496
L04AA06
ATC
mycophenolic acid; systemic
11.8
11.7
21
19
D70.89
ICD-10 Finland
Neutropenic splenomegaly
24.0
11.7
16
7
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.7
11.6
40
95
28398
ICD-8 Finland
Acquired haemolytic anaemias, Aliae definitar
+∞
11.5
11
*
M04AA01
ATC
allopurinol; systemic
3.1
11.5
70
267
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.9
11.4
77
317
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
13.6
10.8
18
14
B03BA03
ATC
hydroxocobalamin; parenteral
4.5
10.7
38
93
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
11.2
10.4
19
18
TK800
NOMESCO Finland
Hemodialysis
9.2
10.0
20
23
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
27.1
9.9
13
5
D64.8
ICD-10 Finland
Other specified anaemias
8.9
9.7
20
24
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
12.9
9.5
16
13
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
22.6
9.4
13
6
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.9
9.3
39
112
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.4
9.2
98
511
H02AB07
ATC
prednisone; oral
2.8
9.2
62
252
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
10.5
9.1
17
17
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.2
8.8
33
86
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
5.7
8.7
24
45
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.1
8.5
32
84
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
8.4
8
*
I50.9
ICD-10 Finland
Heart failure, unspecified
2.6
8.4
64
281
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
5.0
8.4
26
56
3AC01
NOMESCO Finland
NA
12.2
8.2
14
12
A02BC02
ATC
pantoprazole; systemic
2.1
8.1
198
1459
N17.9
ICD-10 Finland
Acute renal failure, unspecified
4.7
8.0
26
59
XF400
NOMESCO Finland
ECG with 12 standard connections
2.5
7.9
68
318
I35.0
ICD-10 Finland
Aortic (valve) stenosis
3.4
7.8
38
124
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
7.8
7.8
17
23
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.8
7.5
18
28
B03XA01
ATC
erythropoietin; parenteral
9.7
7.4
14
15
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
7.3
7
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
16.2
7.3
11
7
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.8
7.3
23
51
B01AB05
ATC
enoxaparin; parenteral
2.1
7.2
102
598
Z94.0
ICD-10 Finland
Kidney transplant status
12.4
7.1
12
10
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
4.0
7.1
27
72
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.2
6.9
25
64
AC4
HP
MVP
41.0
6.8
8
*
127
Kela drug reimbursment
Transplant complication
8.1
6.7
14
18
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.7
6.7
46
190
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
12.6
6.6
11
9
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
12.6
6.6
11
9
I34.1
ICD-10 Finland
Mitral (valve) prolapse
5.9
6.6
17
30
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
6.5
47
196
C03DA01
ATC
spironolactone; oral
2.7
6.5
47
196
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
71.3
6.4
7
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.2
6.4
32
107
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
6.2
6.4
16
27
J01MA12
ATC
levofloxacin; systemic
2.2
6.3
69
359
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
18.5
6.3
9
5
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
6.3
73
391
AC1
HP
MVR mechanical
+∞
6.3
6
*
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
27.3
6.3
8
*
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
7.9
6.2
13
17
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.1
6.0
73
397
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
6.0
23
62
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.1
6.0
22
57
A06AD11
ATC
lactulose; oral
2.3
6.0
59
292
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
151
114
24.25
172.92
6.9
1.9
0.7
1.5
g/l
10.14
99
98
112
62
27.30
146.97
3.8
1.5
—
—
—
0
0
176
303
11.73
112.06
16.2
3.5
436.3
236.1
u/l
8.23
164
287
177
327
10.91
105.40
14.1
2.4
3.4
1.8
%
16.26
167
292
151
235
11.30
103.30
15.5
2.4
120.3
70.6
e9/l
12.19
126
179
142
391
5.74
51.60
5.0
2.3
2.2
2.3
g/l
1.54
135
356
52
48
12.75
49.92
8.8
5.5
259.7
161.2
iu/ml
—
18
5
136
371
5.65
49.70
5.4
2.4
27.4
22.3
%
1.94
117
321
143
431
5.20
45.90
5.4
2.3
14.8
12.9
umol/l
1.34
137
391
172
642
4.64
41.19
4.8
2.1
4.5
3.1
mg/l
3.81
160
552
55
82
7.90
36.49
3.3
2.1
28.0
38.5
mg/l
1.01
44
61
55
82
7.90
36.49
3.3
2.1
74.2
156.6
mg/l
0.44
44
61
87
208
5.38
35.84
3.0
2.1
65.6
66.3
g/l
0.22
80
191
39
9
49.15
32.67
3.4
1.1
—
—
—
0
0
39
9
49.15
32.67
3.4
1.1
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
48
70
7.89
32.34
6.0
3.1
0.3
0.4
u/ml
0.39
31
40
102
301
4.51
32.17
5.7
2.7
13.5
9.0
umol/l
0.89
97
263
28
20
15.25
30.88
3.7
1.3
—
—
—
0
0
102
328
4.10
28.27
14.5
5.7
1.1
1.0
mmol/l
0.80
95
302
50
97
5.93
25.49
3.0
1.6
3.2
3.1
g/l
0.24
34
80
128
511
3.51
25.35
2.4
1.8
1543.2
1208.6
nmol/l
2.05
107
386
51
103
5.70
24.90
2.9
1.6
3.8
3.8
g/l
0.01
34
79
51
103
5.70
24.90
2.9
1.6
5.9
7.4
g/l
5.34
35
82
51
103
5.70
24.90
2.9
1.6
—
—
—
0
0
199
1047
3.39
24.87
7.3
2.7
427.7
125.4
ug/l
6.04
189
956
210
1176
3.30
22.95
13.8
5.7
60.4
57.8
%
2.15
201
1116
106
398
3.49
22.79
6.2
3.6
0.8
0.8
mmol/l
0.63
101
373
46
92
5.67
22.62
3.0
1.8
0.6
0.7
g/l
0.11
38
82
32
44
7.97
22.47
1.4
1.2
—
—
—
0
0
31
42
8.07
22.03
1.5
1.2
243.7
248.0
u/ml
0.03
20
25
46
95
5.49
21.83
3.1
1.6
10.0
10.2
g/l
0.09
35
85
109
429
3.34
21.57
2.8
1.9
—
—
—
0
0
209
1194
3.18
21.54
15.5
5.9
24.9
27.3
%
1.94
200
1123
31
45
7.52
20.75
1.7
1.3
130.5
111.0
u/ml
—
10
6
40
81
5.50
19.33
3.3
1.6
0.0
0.0
g/l
0.00
34
76
198
1151
2.90
18.79
15.1
6.3
1.2
1.2
mmol/l
0.97
186
1044
209
1254
2.93
18.61
18.3
6.9
1.2
1.2
mmol/l
1.06
179
1063
228
1439
3.05
18.38
21.5
8.9
4.6
4.1
e9/l
0.31
212
1270
193
1122
2.82
18.06
10.8
4.5
34.4
35.4
g/l
1.57
178
1046
216
1332
2.93
18.03
20.5
6.0
21.7
11.6
umol/l
6.32
210
1258
133
640
2.85
17.93
4.7
2.7
378.2
7778.8
umol/l
2.99
117
539
37
75
5.45
17.83
8.3
2.6
89.1
87.5
%
0.13
37
70
81
296
3.33
17.73
2.3
1.8
—
—
—
0
0
25
34
7.89
17.63
14.8
1.6
33.9
32.3
pg
1.44
25
34
37
77
5.30
17.31
3.4
1.6
0.0
0.0
g/l
0.00
31
72
79
294
3.24
16.71
2.2
1.7
—
—
—
0
0
38
86
4.88
16.13
3.3
1.6
35.6
37.3
g/l
0.68
32
76
125
615
2.70
15.76
2.3
1.6
23.9
21.0
nmol/l
0.32
115
517
172
1004
2.55
15.03
3.0
2.0
95.1
96.5
pmol/l
0.13
101
516
30
64
5.07
13.60
3.1
1.8
—
—
—
0
0
184
1159
2.39
12.93
12.7
4.2
—
—
—
0
0
30
67
4.84
12.89
3.0
1.8
—
—
—
0
0
23
42
5.82
12.30
2.1
1.9
—
—
—
0
0
32
79
4.39
12.17
6.8
4.0
2.2
1.6
mg/l
2.48
32
71
114
599
2.41
11.92
7.3
2.4
—
—
—
0
0
53
188
3.18
11.91
2.3
1.6
—
—
—
0
0
53
191
3.13
11.59
6.5
4.1
125.1
86.6
ng/l
1.11
46
169
79
356
2.62
11.41
41.6
26.1
1.7
1.3
inr
—
5
52
28
66
4.55
11.26
1.7
1.4
—
—
—
0
0
12
11
11.30
11.12
3.2
2.2
97.6
92.5
%
0.21
12
11
31
82
4.08
10.77
3.9
3.0
—
—
—
0
0
16
24
6.97
10.28
2.3
2.0
—
—
—
0
0
134
798
2.17
10.05
6.9
3.3
45.8
31.7
u/l
2.71
127
761
25
59
4.51
10.03
3.7
3.0
0.7
1.0
nmol/l
1.00
11
49
23
51
4.78
9.94
2.9
1.9
—
—
—
0
0
29
79
3.94
9.67
2.5
2.5
—
—
—
0
0
14
8
18.23
9.48
3.9
1.3
1312.6
1115.1
u/ml
—
14
8
149
941
2.09
9.44
5.8
3.3
—
—
—
0
0
13
17
7.93
9.34
2.3
1.9
9.2
13.1
%
—
5
8
212
1540
2.12
9.07
11.4
4.9
6.7
6.7
mmol/l
0.07
201
1445
19
39
5.12
8.95
1.2
1.2
1.6
1.3
u/ml
—
10
14
20
43
4.90
8.95
2.9
1.7
—
—
—
0
0
131
801
2.08
8.94
6.1
3.1
2218.5
1498.4
ng/l
1.21
119
682
120
724
2.05
8.38
5.8
3.3
0.6
0.4
e6/l
0.16
103
550
19
42
4.75
8.23
1.3
1.2
2.3
4.0
u/ml
0.61
12
19
152
1006
1.98
8.11
3.3
2.3
72.5
75.2
nmol/l
0.65
142
887
16
31
5.38
8.01
1.2
1.1
—
—
—
0
0
133
844
1.99
7.98
4.6
3.2
2.3
2.4
mmol/l
1.58
118
741
43
171
2.75
7.81
4.2
3.0
1.7
1.8
mmol/l
0.05
34
127
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
11
6
18.92
7.65
3.2
2.8
115.6
100.7
%
—
11
6
16
33
5.05
7.49
2.5
2.0
—
—
—
0
0
88
492
2.09
7.41
7.0
3.5
188.6
233.0
ng/l
0.18
78
381
61
294
2.33
7.41
12.4
8.8
1.4
1.3
mmol/l
0.10
49
237
17
38
4.67
7.27
2.4
1.9
—
—
—
0
0
76
409
2.13
7.04
4.9
3.2
2.5
2.0
e6/l
0.36
59
230
11
17
6.67
6.82
2.5
1.9
—
—
—
0
0
19
49
4.06
6.81
1.5
1.3
—
—
—
0
0
19
49
4.06
6.81
1.5
1.3
—
—
—
0
0
25
79
3.35
6.72
1.8
1.2
—
—
—
0
0
44
191
2.51
6.70
4.4
2.9
56.4
66.5
ml/min/173m2
0.77
24
79
51
239
2.35
6.58
4.1
2.4
41.1
34.2
u/l
0.39
45
198
16
37
4.50
6.57
2.2
1.9
—
—
—
0
0
16
37
4.50
6.57
1.1
1.3
—
—
—
0
0
23
70
3.46
6.55
1.9
1.4
—
—
—
0
0
15
33
4.72
6.53
2.5
1.8
—
—
—
0
0
50
234
2.35
6.47
15.1
6.7
1.4
1.4
mmol/l
0.04
45
221
18
47
4.00
6.35
1.4
1.5
—
—
—
0
0
15
34
4.58
6.30
2.9
1.9
—
—
—
0
0
13
27
4.98
6.03
1.8
1.2
15962.5
38339.5
e6/l
—
8
16
18
49
3.83
6.01
1.3
1.1
—
—
—
0
0
36
151
2.56
5.88
1.7
1.6
—
—
—
0
0
10
9
11.42
5.83
4.4
1.4
—
—
—
0
0
91
560
1.87
5.65
5.0
1.8
2.4
1.4
mg/l
0.53
75
438
11
21
5.39
5.56
1.2
1.2
39.2
41.1
u/l
0.09
11
14
75
439
1.93
5.40
4.3
3.0
1.3
0.9
e6/l
0.49
59
259
10
18
5.70
5.35
1.3
1.3
—
—
—
0
0
10
18
5.70
5.35
1.3
1.3
—
—
—
0
0
10
18
5.70
5.35
1.3
1.3
—
—
—
0
0
10
18
5.70
5.35
1.3
1.3
—
—
—
0
0
10
18
5.70
5.35
1.3
1.3
—
—
—
0
0
235
1927
1.83
5.34
20.8
7.4
87.3
80.1
u/l
1.51
230
1788
48
241
2.17
5.24
14.0
4.3
0.8
2.0
mmol/l
1.57
39
189
48
243
2.15
5.13
14.2
9.9
104.4
120.0
g/l
5.80
48
234
34
149
2.43
5.07
2.0
1.5
—
—
—
0
0
226
1847
1.77
5.01
7.3
4.0
23.0
12.3
mm/h
8.35
214
1684
9
10
9.22
4.81
1.6
1.4
—
—
—
0
0
10
20
5.13
4.81
1.3
1.2
—
—
—
0
0
10
21
4.88
4.56
1.3
1.1
—
—
—
0
0
12
31
3.98
4.29
2.9
1.8
—
—
—
0
0
18
62
3.02
4.24
1.9
1.5
—
—
—
0
0
17
57
3.09
4.19
4.5
1.6
11.7
13.0
mg/l
0.28
17
52
16
53
3.13
4.02
8.7
3.4
56.6
58.2
%
0.14
16
53
8
11
7.43
3.88
3.0
5.3
278.9
228.7
u/l
—
8
11
15
49
3.16
3.86
1.7
1.3
—
—
—
0
0
8
12
6.80
3.69
2.9
1.8
—
—
—
0
0
8
12
6.80
3.69
2.9
1.8
—
—
—
0
0
12
35
3.52
3.65
2.7
1.8
88.1
89.4
%
0.37
12
35
7
9
7.92
3.57
1.0
1.1
—
—
—
0
0
8
13
6.28
3.52
2.9
1.8
—
—
—
0
0
200
1662
1.55
3.43
7.5
4.7
38.5
3931.0
e6/l
—
6
36
15
54
2.87
3.30
1.3
1.2
—
—
—
0
0
6
7
8.71
3.27
1.3
1.3
—
—
—
0
0
24
111
2.26
3.22
3.8
1.9
—
—
—
0
0
9
20
4.60
3.13
2.7
2.0
—
—
—
0
0
8
16
5.10
3.07
2.9
1.7
—
—
—
0
0
8
16
5.10
3.07
2.9
1.7
—
—
—
0
0
8
16
5.10
3.07
2.9
1.7
—
—
—
0
0
8
16
5.10
3.07
2.9
2.1
—
—
—
0
0
8
16
5.10
3.07
2.9
1.7
—
—
—
0
0
73
496
1.61
3.03
2.8
2.9
2.4
2.5
mmol/l
0.29
61
431
14
51
2.83
3.02
3.6
2.8
14.6
15.7
%
—
6
24
9
21
4.38
3.01
1.6
1.1
—
—
—
0
0
5
5
10.13
2.99
1.8
1.6
—
—
—
0
0
5
5
10.13
2.99
2.6
1.0
83.6
88.2
%
—
5
5
5
5
10.13
2.99
2.6
1.0
—
—
—
0
0
132
1028
1.48
2.94
6.1
3.9
40.2
36.3
ng/l
0.22
105
748
8
17
4.80
2.93
2.9
2.1
—
—
—
0
0
80
565
1.56
2.81
2.4
1.8
466.0
451.6
pmol/l
0.19
62
473
9
23
4.00
2.79
1.1
1.2
—
—
—
0
0
5
6
8.44
2.76
12.2
7.0
5.0
7.6
mmol/l
—
5
6
15
60
2.57
2.74
1.3
1.4
—
—
—
0
0
7
14
5.09
2.74
2.9
1.4
0.8
1.1
g/l
—
7
14
9
24
3.83
2.69
2.9
1.9
—
—
—
0
0
22
107
2.13
2.64
2.6
1.7
—
—
—
0
0
9
26
3.53
2.50
3.3
1.9
—
—
—
0
0
7
16
4.45
2.49
1.6
1.5
—
—
—
0
0
7
16
4.45
2.49
1.0
1.2
—
—
—
0
0
7
16
4.45
2.49
1.6
1.5
—
—
—
0
0
8
21
3.88
2.48
1.3
1.1
—
—
—
0
0
43
269
1.69
2.45
2.0
2.0
1.4
1.5
%
0.49
35
234
147
1200
1.42
2.43
5.6
3.9
0.0
0.0
estimate
0.00
34
228
5
8
6.33
2.38
1.0
1.6
—
—
—
0
0
29
165
1.83
2.28
9.0
10.1
24.1
24.6
mmol/l
0.25
29
156
208
1821
1.41
2.21
4.2
3.8
15.0
14.8
pmol/l
0.37
186
1636
8
24
3.39
2.19
1.1
1.6
—
—
—
0
0
7
19
3.74
2.16
1.0
1.0
—
—
—
0
0
6
14
4.35
2.16
2.7
4.9
—
—
—
0
0
43
280
1.62
2.12
3.1
4.1
3.1
49.4
ug/l
0.98
36
232
8
26
3.13
2.02
2.9
1.6
—
—
—
0
0
8
26
3.13
2.02
2.9
1.6
—
—
—
0
0
8
26
3.13
2.02
2.9
1.6
—
—
—
0
0
9
32
2.86
2.01
2.9
3.7
—
—
—
0
0
240
2173
1.42
1.97
48.8
16.1
34.3
39.5
%
9.57
164
1530
5
11
4.60
1.95
1.8
3.7
—
—
—
0
0
5
11
4.60
1.95
1.8
3.7
—
—
—
0
0
7
22
3.23
1.89
2.4
2.2
—
—
—
0
0
7
23
3.09
1.81
1.4
1.1
—
—
—
0
0
7
24
2.96
1.73
1.1
1.2
—
—
—
0
0
15
75
2.05
1.72
1.8
1.7
—
—
—
0
0
20
113
1.82
1.64
2.5
3.2
708.6
1684.1
u/ml
0.32
20
97
143
1220
1.31
1.60
5.8
3.9
0.0
0.0
estimate
0.00
32
219
7
26
2.73
1.59
1.3
1.4
—
—
—
0
0
53
387
1.44
1.57
1.3
1.3
35.8
34.8
iu/ml
0.02
13
126
141
1205
1.30
1.55
7.5
5.2
0.0
0.0
estimate
0.00
34
229
167
1465
1.29
1.48
3.2
2.8
—
—
—
0
0
40
554
0.68
1.46
2.3
3.0
0.5
0.8
ug/l
2.76
32
368
50
367
1.43
1.45
1.4
1.3
168.4
11.2
u/ml
0.46
12
140
61
782
0.73
1.43
3.4
4.5
22.4
21.3
%
0.26
27
394
180
1600
1.29
1.42
6.9
3.1
66.1
50.3
u/l
1.71
171
1493
66
519
1.34
1.28
1.4
1.2
2.0
1.7
u/ml
0.07
12
139
8
37
2.19
1.22
1.3
1.6
—
—
—
0
0
8
37
2.19
1.22
1.3
1.6
—
—
—
0
0
8
38
2.13
1.19
1.3
1.6
—
—
—
0
0
8
38
2.13
1.19
1.3
1.6
—
—
—
0
0
8
38
2.13
1.19
1.3
1.6
—
—
—
0
0
8
38
2.13
1.19
1.3
1.6
—
—
—
0
0
6
26
2.33
1.19
1.7
1.2
—
—
—
0
0
38
276
1.43
1.18
7.4
3.5
—
—
—
0
0
5
21
2.40
1.09
2.4
2.7
460.0
587.6
ml
—
5
11
7
34
2.08
1.03
1.0
1.2
—
—
—
0
0
14
84
1.70
0.99
1.0
1.5
—
—
—
0
0
80
671
1.26
0.97
6.4
4.2
0.0
0.0
estimate
0.50
28
221
7
37
1.91
0.94
1.1
1.1
—
—
—
0
0
260
2475
1.27
0.91
43.5
14.9
21.6
23.1
mg/l
0.40
239
1982
241
2275
1.24
0.90
38.4
14.1
71.1
78.6
ml/min/173m2
3.86
210
1866
6
32
1.89
0.82
1.5
1.7
20.9
17.4
ug/l
—
6
32
7
39
1.81
0.73
1.3
1.1
—
—
—
0
0
7
43
1.64
0.67
1.1
2.1
—
—
—
0
0
13
188
0.68
0.64
1.7
2.3
12.7
13.3
nmol/l
—
8
174
214
2026
1.17
0.64
60.7
18.3
15.2
13.8
%
14.51
214
1996
5
29
1.74
0.64
1.2
1.8
—
—
—
0
0
14
197
0.70
0.61
1.1
1.7
—
—
—
0
0
233
2428
0.85
0.60
5.3
5.1
2.4
2.7
mmol/l
5.97
208
2221
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
105
947
1.16
0.59
6.2
4.1
—
—
—
0
0
11
73
1.52
0.57
1.5
1.4
—
—
—
0
0
6
37
1.63
0.56
2.8
3.4
14.0
36.1
u/ml
—
6
37
6
38
1.59
0.54
1.8
1.5
—
—
—
0
0
15
108
1.41
0.54
1.1
1.6
—
—
—
0
0
7
48
1.47
0.47
1.6
1.3
—
—
—
0
0
88
963
0.88
0.44
3.6
5.1
2.7
2.6
ug/l
0.04
78
870
16
122
1.33
0.43
1.1
1.0
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
550.3
—
0
9
0
17
0.00
0.41
0.0
1.1
—
35.0
—
0
9
8
61
1.32
0.40
1.3
1.3
—
—
—
0
0
230
2226
1.12
0.37
5.6
4.5
2.2
2.0
mu/l
1.46
212
2016
10
73
1.38
0.35
1.0
1.2
—
—
—
0
0
6
45
1.34
0.34
1.7
1.6
—
—
—
0
0
266
2714
0.88
0.33
69.1
21.9
3.9
4.5
e12/l
31.15
261
2640
10
74
1.36
0.32
1.0
1.2
—
—
—
0
0
230
2355
0.92
0.26
4.9
4.5
1.4
1.4
mmol/l
0.27
207
2156
33
293
1.14
0.25
1.8
1.4
—
—
—
0
0
33
294
1.14
0.24
11.2
7.9
—
—
—
0
0
33
367
0.89
0.22
1.6
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
224
2284
0.94
0.19
4.8
4.1
1.3
1.3
mmol/l
0.28
199
2085
5
68
0.73
0.17
1.8
1.6
389.4
308.3
mu/l
—
5
61
234
2377
0.94
0.15
5.0
4.5
4.2
4.6
mmol/l
4.46
213
2195
24
217
1.11
0.15
1.3
1.9
—
—
—
0
0
229
2254
1.06
0.14
6.8
6.2
37.6
40.4
mmol/mol
3.04
203
2105
232
2350
0.95
0.12
4.9
4.7
6.1
6.0
mmol/l
0.25
205
2142
21
194
1.09
0.09
1.4
1.8
—
—
—
0
0
7
65
1.08
0.08
1.4
1.3
—
—
—
0
0
32
306
1.05
0.06
3.6
4.4
34.5
32.2
%
0.43
24
205
10
90
1.11
0.05
3.0
1.5
—
—
—
0
0
64
626
1.03
0.04
1.6
1.7
1.5
1.4
mmol/l
0.19
52
522
13
122
1.07
0.02
1.4
1.3
—
—
—
0
0
14
133
1.06
0.01
14.4
2.7
1.3
1.2
%
0.10
14
133
15
148
1.01
0.00
1.1
1.2
173.3
149.7
iu/ml
—
6
50
14
144
0.97
0.00
1.2
1.4
—
40.1
—
0
11
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
4.0
—
0
7
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
4.8
—
60.3
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_ACQHAEMOLYTICANAEMIANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIANAS | 3.114 [2.46, 3.95] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 453 out of 959 females with D3_ACQHAEMOLYTICANAEMIANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIANAS | 3.138 [2.33, 4.22] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 359 out of 817 males with D3_ACQHAEMOLYTICANAEMIANAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_ACQHAEMOLYTICANAEMIANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.352% | 0.488% |
| 5 | 1.783% | 3.256% |
| 10 | 4.076% | 7.853% |
| 15 | 7.3% | 14.352% |
| 20 | 12.566% | 23.308% |
Relationships between endpoints
↥Index endpoint: D3_ACQHAEMOLYTICANAEMIANAS – Other and unspecified acquired haemolytic anaemias
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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