Other and unspecified acquired haemolytic anaemias

D3_ACQHAEMOLYTICANAEMIANAS

hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D59.8, D59.9 Hospital discharge: ICD-9 — 283[2-9] Hospital discharge: ICD-8 — 2830\|28398 Hospital discharge: excluded ICD-9 — 2832B\|2832C Cause of death: ICD-10 — D59.8, D59.9 Cause of death: ICD-9 — 283[2-9] Cause of death: ICD-8 — 2830\|28398 Cause of death: excluded ICD-9 — 2832B\|2832C 2 out of 7 registries used, show all original rules.	319
4. Check minimum number of events None	319
5. Include endpoints None	319
6. Filter based on genotype QC (FinnGen only)	319

Control definitions (FinnGen only)

Control exclude: D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	D3_ACQHAEMOLYTICANAEMIANAS
CONTROL_EXCLUDE	D3_HAEMOLYTICANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D59[8-9]
HD_ICD_9	283[2-9]
HD_ICD_8	2830\|28398
HD_ICD_10_EXCL
HD_ICD_9_EXCL	2832B\|2832C
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D59[8-9]
COD_ICD_9	283[2-9]
COD_ICD_8	2830\|28398
COD_ICD_10_EXCL
COD_ICD_9_EXCL	2832B\|2832C
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other and unspecified acquired haemolytic anaemias based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3078	1682	1353
Only index persons	1978	1086	892
Unadjusted period prevalence (%)
Whole population	0.04	0.05	0.04
Only index persons	0.04	0.04	0.03
Median age at first event (years)
Whole population	66.16	67.62	64.26
Only index persons	61.66	62.26	60.92

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	319	148	171
Unadjusted period prevalence (%)	0.06	0.05	0.08
Median age at first event (years)	61.96	56.44	66.74

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
295: Matched controls
2948

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D59.9

ICD-10 Finland

Acquired haemolytic anaemia, unspecified

8759.1

277.3

222

D59.1

ICD-10 Finland

Other autoimmune haemolytic anaemias

+∞

84.5

D64.9

ICD-10 Finland

Anaemia, unspecified

11.1

57.7

124

181

D59.8

ICD-10 Finland

Other acquired haemolytic anaemias

+∞

50.5

XW000

NOMESCO Finland

Bone marrow biopsy

13.9

34.5

2839X

ICD-9 Finland

Acquired haemolytic anaemias, Acquired haemolytic anaemia, unspecified

+∞

24.3

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

4.8

22.8

238

WW500

NOMESCO Finland

Blood transfusion

9.0

21.6

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.5

20.6

131

552

ZX120

NOMESCO Finland

Intravenous

5.0

19.3

163

H02AB06

ATC

prednisolone; systemic

3.1

19.0

180

994

D59.4

ICD-10 Finland

Other nonautoimmune haemolytic anaemias

+∞

16.8

R50.9

ICD-10 Finland

Fever, unspecified

3.9

16.3

243

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.0

16.2

130

621

B01AA03

ATC

warfarin; systemic

3.2

16.1

108

454

C03CA01

ATC

furosemide; systemic

2.9

16.0

136

672

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

4.9

15.5

125

D69.6

ICD-10 Finland

Thrombocytopenia, unspecified

16.2

15.2

Z95.2

ICD-10 Finland

Presence of prosthetic heart valve

9.7

14.9

138

Kela drug reimbursment

Severe anaemia associated with chronic renal failure

11.3

14.6

L04AX01

ATC

azathioprine; systemic

7.5

14.4

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.6

14.3

161

922

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

4.1

13.3

151

GD1UA

NOMESCO Finland

Thorax X-ray examination outside radiological department

3.2

12.8

282

TPH04

NOMESCO Finland

Cathetrisation of vein

2.9

12.6

394

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.7

12.5

105

499

B03XA02

ATC

darbepoetin alfa; parenteral

11.2

12.0

UJF32

NOMESCO Finland

Coloscopy

2.7

11.8

103

496

L04AA06

ATC

mycophenolic acid; systemic

11.8

11.7

D70.89

ICD-10 Finland

Neutropenic splenomegaly

24.0

11.7

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

4.7

11.6

28398

ICD-8 Finland

Acquired haemolytic anaemias, Aliae definitar

+∞

11.5

M04AA01

ATC

allopurinol; systemic

3.1

11.5

267

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

2.9

11.4

317

WD405

NOMESCO Finland

Simple antiboidy therapy of methastized malignancy

13.6

10.8

B03BA03

ATC

hydroxocobalamin; parenteral

4.5

10.7

TFC00

NOMESCO Finland

Catheterisation of right atrium or ventricle

11.2

10.4

TK800

NOMESCO Finland

Hemodialysis

9.2

10.0

D69.3

ICD-10 Finland

Idiopathic thrombocytopenic purpura

27.1

9.9

D64.8

ICD-10 Finland

Other specified anaemias

8.9

9.7

TNE25

NOMESCO Finland

Drill biopsy of bone marrow, pelvis

12.9

9.5

FKB10

NOMESCO Finland

Annuloplasty of mitral valve for insufficiency using ring

22.6

9.4

N18.9

ICD-10 Finland

Chronic kidney disease, unspecified

3.9

9.3

112

I48

ICD-10 Finland

Atrial fibrillation and flutter

2.4

9.2

511

ZXD05

NOMESCO Finland

Urgent procedure

2.3

9.2

112

627

H02AB07

ATC

prednisone; oral

2.8

9.2

252

WD415

NOMESCO Finland

Demanding antibody therapy of methastized malignancy

10.5

9.1

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

4.2

8.8

D50.0

ICD-10 Finland

Iron deficiency anaemia secondary to blood loss (chronic)

5.7

8.7

TPH15

NOMESCO Finland

Insertion of central venous catheter through external or internal jugular vein

4.1

8.5

D59.0

ICD-10 Finland

Drug-induced autoimmune haemolytic anaemia

+∞

8.4

I50.9

ICD-10 Finland

Heart failure, unspecified

2.6

8.4

281

I34.09

ICD-10 Finland

Mitral (valve) insufficiency

5.0

8.4

3AC01

NOMESCO Finland

12.2

8.2

A02BC02

ATC

pantoprazole; systemic

2.1

8.1

198

1459

N17.9

ICD-10 Finland

Acute renal failure, unspecified

4.7

8.0

XF400

NOMESCO Finland

ECG with 12 standard connections

2.5

7.9

318

I35.0

ICD-10 Finland

Aortic (valve) stenosis

3.4

7.8

124

R17

ICD-10 Finland

Hyperbilirubinaemia, with or without jaundice, not elsewhere classified

7.8

123

Kela drug reimbursment

Chronic disorders of vitamin D metabolism

6.8

7.5

B03XA01

ATC

erythropoietin; parenteral

9.7

7.4

28390

ICD-8 Finland

Acquired haemolytic anaemias, Autoimmunisatoria primaria

+∞

7.3

JMA10

NOMESCO Finland

Transabdominal total splenectomy

16.2

7.3

A41.5

ICD-10 Finland

Sepsis due to other Gram-negative organisms

4.8

7.3

ZXE30

NOMESCO Finland

More than five and less than seven hours

4.2

7.2

B01AB05

ATC

enoxaparin; parenteral

2.1

7.2

102

598

Z94.0

ICD-10 Finland

Kidney transplant status

12.4

7.1

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

4.0

7.1

PG1DE

NOMESCO Finland

Other extensive ultrasound examination of artery

4.2

6.9

AC4

MVP

41.0

6.8

127

Kela drug reimbursment

Transplant complication

8.1

6.7

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.7

6.7

190

L04AD02

ATC

tacrolimus; systemic (calcineurin inhibitors)

12.6

6.6

D62

ICD-10 Finland

Acute posthaemorrhagic anaemia

12.6

6.6

I34.1

ICD-10 Finland

Mitral (valve) prolapse

5.9

6.6

A49.9

ICD-10 Finland

Bacterial infection, unspecified

2.7

6.5

196

C03DA01

ATC

spironolactone; oral

2.7

6.5

196

D80.1

ICD-10 Finland

Nonfamilial hypogammaglobulinaemia

71.3

6.4

FM1BE

NOMESCO Finland

Cardiac ultrasound examination through oesophagus

3.2

6.4

107

I34.00

ICD-10 Finland

Mitral (valve) incompetence NOS or of specified cause, except rheumatic

6.2

6.4

J01MA12

ATC

levofloxacin; systemic

2.2

6.3

359

D53.1

ICD-10 Finland

Other megaloblastic anaemias, not elsewhere classified

18.5

6.3

Z01.8

ICD-10 Finland

Other specified special examinations

2.2

6.3

391

AC1

MVR mechanical

+∞

6.3

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

27.3

6.3

D51.9

ICD-10 Finland

Vitamin B12deficiency anaemia, unspecified

7.9

6.2

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.1

6.0

397

GD1AD

NOMESCO Finland

Thorax CT examination

3.9

6.0

FXA00

NOMESCO Finland

Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure

4.1

6.0

A06AD11

ATC

lactulose; oral

2.3

6.0

292

Mortality – FinRegistry

↥

Association

Association between endpoint D3_ACQHAEMOLYTICANAEMIANAS and mortality.

Females

Parameter	HR [95% CI]	p-value
D3_ACQHAEMOLYTICANAEMIANAS	3.114 [2.46, 3.95]	< 0.001
Birth year	0.992 [0.98, 1.0]	0.071

During the follow-up period (1.1.1998 — 31.12.2019), 453 out of 959 females with D3_ACQHAEMOLYTICANAEMIANAS died.

Males

Parameter	HR [95% CI]	p-value
D3_ACQHAEMOLYTICANAEMIANAS	3.138 [2.33, 4.22]	< 0.001
Birth year	0.982 [0.97, 0.99]	< 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 359 out of 817 males with D3_ACQHAEMOLYTICANAEMIANAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_ACQHAEMOLYTICANAEMIANAS.

N-year risk	Females	Males
1	0.352%	0.488%
5	1.783%	3.256%
10	4.076%	7.853%
15	7.3%	14.352%
20	12.566%	23.308%

Relationships between endpoints

↥

Index endpoint: D3_ACQHAEMOLYTICANAEMIANAS – Other and unspecified acquired haemolytic anaemias

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified acquired haemolytic anaemias

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints