hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Other and unspecified acquired haemolytic anaemias
DOID EFO Endpoint Browser PheWeb
D3_ACQHAEMOLYTICANAEMIANAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
344 |
4. Check minimum number of eventsNone |
344 |
5. Include endpointsNone |
344 |
6. Filter based on genotype QC (FinnGen only) |
332 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified acquired haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3078 | 1682 | 1353 |
| Only index persons | 1978 | 1086 | 892 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 66.16 | 67.62 | 64.26 |
| Only index persons | 61.66 | 62.26 | 60.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 332 | 151 | 181 |
| Unadjusted period prevalence (%) | 0.07 | 0.05 | 0.08 |
| Median age at first event (years) | 63.38 | 57.56 | 68.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 344
- Matched controls
- 3440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
307.7
265
*
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
97.7
89
*
D64.9
ICD-10 Finland
Anaemia, unspecified
10.2
97.4
147
234
XW000
NOMESCO Finland
Bone marrow biopsy
12.4
66.0
72
72
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
59.1
55
*
WW500
NOMESCO Finland
Blood transfusion
9.4
44.0
57
71
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.4
41.0
102
250
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
12.4
35.9
37
33
ZX120
NOMESCO Finland
Intravenous
5.0
30.7
77
187
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.6
30.1
163
687
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.5
29.4
64
137
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
11.2
26.6
29
28
L04AX01
ATC
azathioprine; systemic
7.7
26.4
39
56
2839X
ICD-9 Finland
Acquired haemolytic anaemias, Acquired haemolytic anaemia, unspecified
+∞
26.4
25
*
B01AA03
ATC
warfarin; systemic
3.3
23.6
123
493
R50.9
ICD-10 Finland
Fever, unspecified
3.7
23.3
90
298
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
7.1
20.9
33
51
I35.0
ICD-10 Finland
Aortic (valve) stenosis
4.7
20.6
52
125
C03CA01
ATC
furosemide; systemic
2.8
20.1
169
871
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
20.0
19
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.9
19.9
47
107
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
19.7
112
466
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.1
19.2
59
165
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.2
19.2
94
358
H02AB06
ATC
prednisolone; systemic
2.8
19.0
208
1218
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.8
18.8
161
832
D64.8
ICD-10 Finland
Other specified anaemias
13.6
17.5
30
24
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.1
15.9
47
127
UJF32
NOMESCO Finland
Coloscopy
2.7
15.9
124
601
M04AA01
ATC
allopurinol; systemic
3.2
15.9
76
283
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
4.3
15.5
43
111
B03BA03
ATC
hydroxocobalamin; parenteral
4.3
15.4
42
107
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.5
15.3
193
1167
L04AA06
ATC
mycophenolic acid; systemic
13.3
15.1
26
21
H02AB07
ATC
prednisone; oral
3.1
14.7
71
265
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.7
14.1
93
411
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
14.1
127
654
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
17.1
13.6
21
13
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
5.9
13.6
25
45
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.1
13.3
29
61
ZXD05
NOMESCO Finland
Urgent procedure
2.4
13.2
129
685
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
13.7
13.1
22
17
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.9
13.0
40
111
B03XA02
ATC
darbepoetin alfa; parenteral
10.3
13.0
25
26
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.9
12.1
38
107
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.4
11.8
112
583
28398
ICD-8 Finland
Acquired haemolytic anaemias, Aliae definitar
+∞
11.5
11
*
D59.0
ICD-10 Finland
Drug-induced autoimmune haemolytic anaemia
+∞
11.5
11
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
4.5
11.5
29
69
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
4.3
11.5
31
78
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
11.5
61
239
TNE25
NOMESCO Finland
Drill biopsy of bone marrow, pelvis
15.7
11.4
18
12
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
11.4
96
473
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
8.5
11.3
24
30
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
11.2
35
98
WX872
NOMESCO Finland
Intensive care
4.0
11.0
32
85
TK800
NOMESCO Finland
Hemodialysis
8.7
11.0
23
28
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
11.1
10.9
20
19
3AC01, ,
NOMESCO Finland
18.6
10.8
16
9
A02BC02
ATC
pantoprazole; systemic
2.3
10.6
247
1819
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.2
10.5
29
74
I34.1
ICD-10 Finland
Mitral (valve) prolapse
5.2
10.4
22
45
TGC00
NOMESCO Finland
Bronchial lavation
5.2
10.4
22
45
L04AD02
ATC
tacrolimus; systemic
24.2
10.3
14
6
B01AB05
ATC
enoxaparin; parenteral
2.2
10.2
129
748
B03XA01
ATC
erythropoietin; parenteral
15.2
10.1
16
11
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
17.3
10.0
15
9
127
Kela drug reimbursment
Transplant complication
12.7
10.0
17
14
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.0
9.8
29
78
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
3.8
9.7
31
88
I50.9
ICD-10 Finland
Heart failure, unspecified
2.4
9.7
81
395
C03DA01
ATC
spironolactone; oral
2.6
9.6
62
268
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
14.2
9.3
15
11
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
7.1
9.0
21
31
K83
ICPC
Heart valve disease NOS
13.0
8.9
15
12
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
11.1
8.9
16
15
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
8.8
65
298
XF400
NOMESCO Finland
ECG with 12 standard connections
2.3
8.8
74
361
JN4BD
NOMESCO Finland
Extensive body CT
2.7
8.6
50
204
I50.0
ICD-10 Finland
Congestive heart failure
2.8
8.5
45
175
Z94.0
ICD-10 Finland
Kidney transplant status
14.9
8.3
13
9
B82
ICPC
Anaemia other/unspecified
4.7
8.2
19
42
C01BD01
ATC
amiodarone; systemic
4.7
8.2
19
42
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.5
8.2
55
241
JN3AD
NOMESCO Finland
Abdominal CT examination
2.6
8.1
50
210
JMA10
NOMESCO Finland
Transabdominal total splenectomy
17.7
8.1
12
7
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
4.3
8.1
21
51
B81
ICPC
Anaemia vit B12/folate deficiency
3.9
8.0
24
65
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
6.4
8.0
20
33
B80
ICPC
Iron deficiency anaemia
7.0
7.7
18
27
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
18.9
7.6
11
6
D70.89
ICD-10 Finland
Neutropenic splenomegaly
9.2
7.6
15
17
UJF92
NOMESCO Finland
Capsular endoscopy
7.4
7.6
17
24
K78
ICPC
Atrial fibrillation/flutter
2.7
7.5
41
162
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
7.5
51
225
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
81.8
7.4
8
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
7.4
80
429
WX892
NOMESCO Finland
Monitored bed care
3.0
7.4
34
122
A12AA04
ATC
calcium carbonate; oral
8.7
7.4
15
18
28390
ICD-8 Finland
Acquired haemolytic anaemias, Autoimmunisatoria primaria
+∞
7.3
7
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.8
7.3
22
60
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
7.3
65
323
1XC02, ,
NOMESCO Finland
30.7
7.2
9
*
NEA10
NOMESCO Finland
Exploration of soft tissue of pelvis, percutaneous
30.7
7.2
9
*
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
8.2
7.2
15
19
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
20.5
7.2
10
5
K92.1
ICD-10 Finland
Melaena
3.1
7.2
30
102
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.7
7.1
23
66
A11CC03
ATC
alfacalcidol; systemic
6.1
7.0
18
31
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
7.0
44
187
A06AD11
ATC
lactulose; oral
2.2
7.0
66
336
SPAT1255
SPAT
Intravenous administration of medicine
3.0
6.9
31
110
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
40.9
6.8
8
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
17.1
6.8
10
6
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
6.7
122
782
A10AB05
ATC
insulin aspart; parenteral
2.6
6.7
39
159
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
5.7
6.7
18
33
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
4.3
6.6
17
41
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
12.6
6.6
11
9
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
12.6
6.6
11
9
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.3
6.6
25
80
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.4
6.5
16
26
H03AA01
ATC
levothyroxine sodium; systemic
2.0
6.5
80
449
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
3.1
6.5
28
97
Z49.1
ICD-10 Finland
Extracorporeal dialysis
8.4
6.4
13
16
C01AA05
ATC
digoxin; systemic
2.4
6.3
44
196
D59.5
ICD-10 Finland
Paroxysmal nocturnal haemoglobinuria [Marchiafava-Micheli]
+∞
6.3
6
*
XG410
NOMESCO Finland
Flow-volume spirometry
3.4
6.2
22
67
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.4
6.2
44
198
M05BA04
ATC
alendronic acid; oral
2.5
6.2
39
166
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.0
6.1
27
95
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
6.1
96
586
I50.1
ICD-10 Finland
Left ventricular failure
2.9
6.1
28
101
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
6.0
48
227
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
6.0
139
953
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
165
122
25.07
191.35
6.7
1.8
0.72
1.54
g/l
11.75
107
106
123
65
28.90
164.94
3.7
1.5
—
—
—
0
0
194
320
12.61
128.91
15.4
3.4
429.08
236.88
u/l
8.84
181
304
196
348
11.77
121.79
13.6
2.4
3.41
1.76
%
17.88
186
311
169
250
12.32
121.39
14.7
2.3
119.96
70.31
e9/l
13.77
142
189
58
48
14.33
59.74
8.3
5.5
247.95
161.20
iu/ml
—
19
5
156
418
6.00
58.91
5.1
2.3
2.18
2.31
g/l
1.82
149
383
148
397
5.79
55.34
5.4
2.3
27.49
22.17
%
2.15
128
344
157
457
5.48
53.07
5.4
2.3
14.83
12.78
umol/l
1.60
151
420
190
691
4.91
47.80
4.7
2.1
4.37
3.08
mg/l
3.84
176
594
99
209
6.25
47.42
4.1
2.5
10.27
10.44
g/l
0.06
93
190
100
227
5.80
44.06
2.9
2.0
65.34
66.29
g/l
0.38
93
207
63
94
7.98
41.85
3.1
2.0
71.80
138.68
mg/l
0.41
47
73
63
94
7.98
41.85
3.1
2.0
27.91
37.09
mg/l
1.02
47
73
41
10
46.36
33.93
3.3
1.1
—
—
—
0
0
41
10
46.36
33.93
3.3
1.1
—
—
—
0
0
107
322
4.37
32.66
6.0
2.7
14.84
9.05
umol/l
1.18
101
282
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
50
77
7.43
32.02
5.8
3.0
0.31
0.36
u/ml
0.50
31
44
219
1112
3.67
30.11
7.3
2.7
435.59
128.08
ug/l
6.29
209
1017
33
34
10.63
29.00
13.1
1.6
33.73
32.38
pg
1.22
33
34
109
360
3.97
28.90
15.0
5.4
1.12
1.04
mmol/l
1.16
101
330
232
1274
3.52
27.07
13.9
5.6
60.13
57.73
%
1.89
223
1209
230
1257
3.50
27.03
15.5
5.6
2.43
2.88
%
2.71
221
1183
137
558
3.42
26.03
2.3
1.7
1544.78
1201.86
nmol/l
2.28
114
420
35
45
8.55
26.00
1.3
1.2
—
—
—
0
0
231
1292
3.40
25.59
15.5
5.8
25.09
27.27
%
1.62
222
1223
34
43
8.66
25.59
1.4
1.2
270.20
248.04
u/ml
0.14
23
25
53
109
5.57
25.30
2.9
1.6
3.07
2.96
g/l
0.28
48
100
54
115
5.38
24.79
2.9
1.6
5.79
7.33
g/l
7.23
49
106
54
115
5.38
24.79
2.9
1.6
—
—
—
0
0
54
115
5.38
24.79
2.9
1.6
3.52
3.61
g/l
0.11
49
106
34
45
8.27
24.65
1.7
1.3
128.55
111.00
u/ml
—
11
6
113
432
3.41
23.43
6.6
3.5
0.80
0.82
mmol/l
0.78
107
406
49
102
5.44
23.02
3.0
1.7
0.60
0.65
g/l
0.05
41
91
118
471
3.29
22.71
2.7
1.8
—
—
—
0
0
49
106
5.22
22.02
3.0
1.6
9.85
10.18
g/l
0.15
44
96
251
1554
3.28
21.87
21.2
8.8
4.55
4.17
e9/l
0.28
234
1367
218
1251
3.03
21.70
15.3
6.1
1.20
1.21
mmol/l
1.15
204
1137
213
1211
2.99
21.49
10.8
4.5
34.52
35.44
g/l
1.41
198
1130
144
665
3.00
21.30
2.3
1.6
23.09
20.76
nmol/l
0.30
131
559
236
1436
3.05
20.71
20.3
6.0
21.75
11.57
umol/l
6.71
230
1355
227
1360
2.97
20.36
18.5
6.7
1.20
1.21
mmol/l
1.34
192
1161
31
21
16.10
19.32
3.6
1.3
—
—
—
0
0
89
327
3.32
19.29
2.3
1.8
—
—
—
0
0
42
91
5.12
18.77
3.2
1.6
0.00
0.00
g/l
-0.00
36
85
142
692
2.79
18.49
4.6
2.7
376.10
8435.46
umol/l
3.42
125
588
87
326
3.23
18.17
2.2
1.7
—
—
—
0
0
39
85
5.05
17.28
3.3
1.6
0.00
0.00
g/l
-0.00
33
79
189
1092
2.62
17.13
2.9
2.0
95.93
95.98
pmol/l
0.00
112
561
38
84
4.96
16.55
3.4
1.6
0.00
0.00
g/l
-0.00
33
79
33
66
5.42
16.08
2.9
1.8
—
—
—
0
0
40
95
4.63
15.99
3.3
1.5
35.85
37.60
g/l
0.81
35
86
212
1340
2.52
15.24
42.7
15.1
1.56
1.29
inr
2.81
65
398
26
44
6.31
15.01
2.0
1.9
—
—
—
0
0
37
89
4.54
14.53
7.9
3.8
2.06
1.56
mg/l
2.24
37
78
201
1261
2.43
14.38
7.4
2.6
—
—
—
0
0
32
70
4.94
14.07
2.8
1.7
—
—
—
0
0
35
84
4.53
13.78
2.5
2.4
—
—
—
0
0
24
43
5.92
13.08
2.5
1.7
—
—
—
0
0
24
43
5.92
13.08
2.5
1.7
—
—
—
0
0
31
71
4.70
12.90
1.6
1.4
—
—
—
0
0
117
602
2.43
12.77
4.4
2.7
5.28
4.54
e6/l
0.22
105
545
56
203
3.10
12.08
2.3
1.6
—
—
—
0
0
27
61
4.72
11.41
3.5
3.0
0.70
1.01
nmol/l
0.98
11
51
120
654
2.28
11.25
7.3
2.4
—
—
—
0
0
145
858
2.19
11.07
7.3
3.3
44.80
31.52
u/l
2.75
137
816
164
1019
2.16
11.06
5.6
3.3
—
—
—
0
0
145
860
2.19
10.99
5.8
3.4
23.53
130.50
e6/l
0.82
125
670
33
90
3.95
10.97
3.8
3.1
—
—
—
0
0
144
859
2.16
10.69
5.9
3.1
2176.63
1527.35
ng/l
1.13
130
729
232
1664
2.21
10.65
11.7
4.8
6.74
6.72
mmol/l
0.05
220
1564
24
52
4.89
10.64
2.8
1.9
—
—
—
0
0
55
214
2.87
10.42
7.1
4.0
126.71
85.53
ng/l
1.29
48
188
27
68
4.22
9.97
7.0
3.0
35.52
36.31
umol/l
0.05
27
58
132
780
2.12
9.88
5.6
3.3
0.53
0.43
e6/l
0.17
113
592
147
905
2.09
9.87
4.3
3.2
2.31
2.35
mmol/l
2.44
131
802
20
40
5.25
9.69
2.2
1.8
—
—
—
0
0
20
40
5.25
9.69
1.2
1.2
1.60
1.29
u/ml
—
10
14
21
44
5.02
9.67
2.8
1.7
—
—
—
0
0
14
8
18.18
9.48
3.9
1.3
1312.57
1115.13
u/ml
—
14
8
19
39
5.10
8.94
2.1
1.8
—
—
—
0
0
138
858
2.02
8.78
4.7
2.4
71.08
61.83
u/l
0.48
132
790
165
1093
1.98
8.75
3.4
2.3
72.45
76.03
nmol/l
1.01
154
965
20
44
4.76
8.70
1.3
1.2
2.33
4.00
u/ml
0.61
12
19
68
323
2.38
8.54
11.8
8.3
1.39
1.22
mmol/l
0.15
54
265
47
187
2.75
8.50
4.5
3.0
1.65
1.75
mmol/l
0.04
37
138
96
534
2.11
8.19
6.7
3.5
173.31
244.21
ng/l
0.34
86
419
67
322
2.34
8.17
11.9
8.3
11.74
12.06
kpa
0.20
62
311
49
207
2.59
7.87
4.4
3.0
58.08
64.81
ml/min/173m2
0.45
26
85
26
79
3.48
7.40
1.9
1.4
—
—
—
0
0
17
25
7.10
7.38
2.0
1.9
—
—
—
0
0
13
12
11.20
7.36
3.8
2.1
94.00
96.17
%
0.08
13
12
102
602
1.99
7.30
4.7
1.8
2.26
1.40
mg/l
0.46
84
472
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
11
7
16.17
7.27
3.2
2.6
115.64
104.86
%
—
11
7
259
2077
2.00
7.10
20.9
7.4
86.24
80.15
u/l
1.31
254
1933
127
816
1.88
7.01
2.7
2.1
145.55
213.36
u/l
1.53
122
771
20
53
3.94
6.91
1.5
1.3
—
—
—
0
0
20
53
3.94
6.91
1.5
1.3
—
—
—
0
0
17
40
4.42
6.83
1.1
1.3
—
—
—
0
0
249
1986
1.92
6.73
7.5
4.0
23.46
12.38
mm/h
9.59
237
1812
80
446
2.03
6.65
4.9
3.2
2.44
1.93
e6/l
0.33
61
250
26
85
3.23
6.62
1.8
1.2
—
—
—
0
0
54
259
2.29
6.56
15.1
4.2
0.91
1.97
mmol/l
1.50
45
206
16
26
6.40
6.54
2.4
1.7
—
—
—
0
0
16
26
6.40
6.54
2.4
1.7
—
—
—
0
0
20
56
3.73
6.41
7.5
3.4
58.65
58.32
%
0.03
20
56
54
263
2.25
6.33
4.2
2.4
45.90
34.03
u/l
0.81
48
218
6
0
+∞
6.27
1.2
0.0
—
—
—
0
0
19
54
3.67
5.97
1.4
1.5
—
—
—
0
0
17
34
5.20
5.95
2.4
2.0
—
—
—
0
0
17
35
5.05
5.82
1.2
1.1
—
—
—
0
0
19
55
3.60
5.82
1.3
1.1
—
—
—
0
0
16
31
5.36
5.77
2.5
2.0
—
—
—
0
0
13
20
6.71
5.61
1.2
1.3
—
—
—
0
0
13
20
6.71
5.61
1.2
1.3
—
—
—
0
0
13
20
6.71
5.61
1.2
1.3
—
—
—
0
0
13
20
6.71
5.61
1.2
1.3
—
—
—
0
0
13
20
6.71
5.61
1.2
1.3
—
—
—
0
0
80
472
1.91
5.58
4.3
3.0
1.32
0.90
e6/l
0.60
62
275
10
10
10.26
5.56
1.5
1.4
—
—
—
0
0
10
10
10.26
5.56
4.4
1.4
—
—
—
0
0
12
17
7.27
5.48
2.6
1.9
—
—
—
0
0
36
157
2.44
5.41
1.9
1.5
—
—
—
0
0
16
34
4.88
5.37
2.4
1.8
—
—
—
0
0
38
175
2.32
5.07
2.0
1.6
—
—
—
0
0
14
28
5.17
5.00
1.9
1.2
15962.50
38525.41
e6/l
—
8
17
20
67
3.11
4.91
1.8
1.5
—
—
—
0
0
172
1307
1.63
4.75
5.3
3.8
0.00
0.00
estimate
0.50
46
270
15
35
4.43
4.69
2.9
1.9
—
—
—
0
0
11
21
5.37
4.17
1.3
1.1
—
—
—
0
0
91
605
1.69
4.15
2.4
1.7
485.17
449.40
pmol/l
0.61
71
502
219
1801
1.59
4.11
7.2
4.7
34.86
3540.75
e6/l
—
7
40
14
36
4.01
4.04
2.7
1.9
88.33
89.40
%
0.32
14
36
13
32
4.18
3.94
2.8
1.8
—
—
—
0
0
11
23
4.90
3.90
1.1
1.2
—
—
—
0
0
16
54
3.06
3.90
4.0
2.8
14.21
16.00
%
—
7
26
7
8
8.90
3.79
1.3
1.3
—
—
—
0
0
6
5
12.18
3.77
2.3
1.0
87.83
88.20
%
—
6
5
59
356
1.79
3.77
16.1
6.4
104.97
103.93
mmol/l
0.94
59
356
81
535
1.67
3.76
2.7
2.9
2.44
2.45
mmol/l
0.34
68
469
8
12
6.79
3.69
2.9
1.8
—
—
—
0
0
8
12
6.79
3.69
2.9
1.8
—
—
—
0
0
8
12
6.79
3.69
3.0
4.9
278.87
225.17
u/l
—
8
12
144
1101
1.53
3.58
6.1
3.8
38.16
36.28
ng/l
0.10
117
798
167
1318
1.52
3.58
5.4
3.9
0.00
0.00
estimate
-0.00
41
234
8
13
6.27
3.52
2.9
1.8
—
—
—
0
0
6
6
10.15
3.51
10.5
7.0
5.05
7.62
mmol/l
—
6
6
165
1304
1.51
3.48
7.1
5.2
0.00
0.00
estimate
-0.00
44
245
50
295
1.81
3.44
6.4
3.4
—
—
—
0
0
7
10
7.12
3.38
1.0
1.1
—
—
—
0
0
8
14
5.82
3.36
3.1
1.4
0.83
1.10
g/l
—
8
14
10
23
4.45
3.33
1.3
1.1
—
—
—
0
0
10
24
4.26
3.22
1.5
1.2
—
—
—
0
0
15
55
2.81
3.19
1.3
1.2
—
—
—
0
0
15
56
2.76
3.10
1.7
1.4
—
—
—
0
0
6
8
7.61
3.06
1.3
1.6
—
—
—
0
0
13
45
2.96
3.06
20.1
2.8
69.08
61.73
%
0.53
13
45
9
21
4.37
3.01
2.7
2.0
—
—
—
0
0
48
292
1.75
2.98
2.2
1.9
1.46
1.52
%
0.30
39
256
25
122
2.13
2.95
3.7
1.9
—
—
—
0
0
8
17
4.79
2.93
2.9
1.6
—
—
—
0
0
8
17
4.79
2.93
2.9
1.6
—
—
—
0
0
8
17
4.79
2.93
2.9
2.1
—
—
—
0
0
9
22
4.17
2.90
1.2
1.1
—
—
—
0
0
8
18
4.52
2.81
2.9
2.1
—
—
—
0
0
10
28
3.65
2.80
2.5
1.5
—
—
—
0
0
10
28
3.65
2.80
2.5
1.5
—
—
—
0
0
10
28
3.65
2.80
2.5
1.5
—
—
—
0
0
228
1972
1.46
2.79
4.4
3.8
15.07
14.86
pmol/l
0.55
203
1767
62
412
1.62
2.78
1.4
1.3
51.65
35.83
iu/ml
0.42
20
135
5
6
8.43
2.76
1.8
1.5
—
—
—
0
0
59
390
1.62
2.70
1.4
1.3
160.21
10.62
u/ml
0.43
12
151
9
24
3.82
2.69
2.1
2.1
—
—
—
0
0
7
15
4.74
2.61
2.4
4.7
—
—
—
0
0
9
25
3.67
2.59
2.9
2.0
—
—
—
0
0
7
16
4.44
2.48
1.0
1.2
—
—
—
0
0
23
118
2.02
2.42
2.6
1.7
—
—
—
0
0
9
27
3.39
2.41
1.4
1.1
—
—
—
0
0
9
27
3.39
2.41
3.3
1.9
—
—
—
0
0
15
65
2.37
2.35
1.3
1.5
—
—
—
0
0
95
719
1.44
2.32
5.8
4.2
0.05
0.01
estimate
0.33
38
236
7
18
3.95
2.26
1.6
1.4
—
—
—
0
0
7
18
3.95
2.26
1.6
1.4
—
—
—
0
0
8
24
3.39
2.19
1.1
1.2
—
—
—
0
0
23
123
1.93
2.17
2.4
3.3
619.35
1530.54
u/ml
0.33
23
107
10
38
2.68
2.02
1.1
1.1
—
—
—
0
0
77
576
1.43
1.99
1.3
1.2
1.95
1.74
u/ml
0.05
13
151
7
21
3.38
1.97
1.0
1.0
—
—
—
0
0
45
302
1.56
1.95
3.1
4.0
3.10
46.27
ug/l
1.00
37
252
5
11
4.59
1.95
1.8
3.7
—
—
—
0
0
5
11
4.59
1.95
1.8
3.7
—
—
—
0
0
17
85
2.05
1.93
1.7
1.7
—
—
—
0
0
9
34
2.69
1.88
2.9
3.6
—
—
—
0
0
8
28
2.90
1.87
1.1
1.5
—
—
—
0
0
106
847
1.36
1.85
5.0
3.7
20.04
9.42
mg/mmol
1.25
75
536
182
1588
1.31
1.71
3.2
2.8
—
—
—
0
0
43
604
0.67
1.67
2.2
2.9
0.51
0.80
ug/l
3.10
33
399
195
1722
1.31
1.65
7.4
3.1
66.42
50.77
u/l
1.81
183
1602
122
1018
1.31
1.56
5.6
4.0
—
—
—
0
0
7
27
2.62
1.52
1.3
1.4
—
—
—
0
0
16
87
1.88
1.48
1.4
1.4
0.01
0.04
iu/ml
—
5
18
284
2668
1.37
1.41
43.0
14.8
21.17
23.33
mg/l
0.70
260
2136
6
23
2.64
1.37
2.2
2.7
503.33
576.08
ml
—
6
12
8
37
2.19
1.22
1.0
1.2
—
—
—
0
0
8
40
2.02
1.12
1.3
1.6
—
—
—
0
0
8
40
2.02
1.12
1.3
1.6
—
—
—
0
0
8
41
1.97
1.09
1.3
1.6
—
—
—
0
0
8
41
1.97
1.09
1.3
1.6
—
—
—
0
0
8
41
1.97
1.09
1.3
1.6
—
—
—
0
0
8
41
1.97
1.09
1.3
1.6
—
—
—
0
0
70
849
0.78
1.07
4.2
4.5
21.84
21.36
%
0.11
32
420
262
2468
1.26
1.03
38.2
14.1
71.72
78.84
ml/min/173m2
3.96
231
2021
244
2282
1.24
1.02
58.3
17.8
15.47
15.13
%
0.72
244
2252
7
36
1.96
0.97
3.3
1.9
3.83
10.37
umol/l
—
7
26
6
29
2.09
0.89
1.7
1.4
—
—
—
0
0
14
209
0.66
0.78
1.1
1.7
—
—
—
0
0
254
2413
1.20
0.77
5.6
4.5
2.16
1.95
mu/l
1.33
232
2181
14
91
1.56
0.76
1.0
1.5
—
—
—
0
0
11
67
1.66
0.76
1.3
1.3
—
—
—
0
0
7
40
1.77
0.71
1.3
1.1
—
—
—
0
0
77
669
1.19
0.66
1.7
1.7
1.37
1.38
mmol/l
0.03
62
559
12
79
1.54
0.63
1.5
1.4
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
8
53
1.52
0.59
2.0
1.4
—
—
—
0
0
15
207
0.71
0.59
1.8
2.3
13.13
13.28
nmol/l
—
9
192
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
6
35
1.73
0.58
1.5
1.7
20.87
17.67
ug/l
—
6
35
7
48
1.47
0.47
1.1
2.0
—
—
—
0
0
253
2441
1.14
0.46
6.8
6.1
37.52
40.35
mmol/mol
3.51
222
2271
37
315
1.20
0.42
1.8
1.4
—
—
—
0
0
5
33
1.52
0.41
1.2
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
582.20
—
0
10
0
18
0.00
0.40
0.0
1.0
—
34.03
—
0
9
9
69
1.31
0.37
1.6
1.3
—
—
—
0
0
6
41
1.47
0.36
1.8
1.5
—
—
—
0
0
256
2629
0.90
0.35
5.4
5.0
2.35
2.69
mmol/l
6.98
225
2405
15
118
1.28
0.34
1.1
1.6
—
—
—
0
0
6
47
1.28
0.32
1.7
1.6
—
—
—
0
0
17
138
1.24
0.31
15.3
2.7
1.37
1.19
%
0.33
17
138
16
129
1.25
0.31
1.1
1.0
—
—
—
0
0
10
76
1.33
0.28
1.0
1.2
—
—
—
0
0
10
77
1.31
0.26
1.0
1.2
—
—
—
0
0
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
7
92
0.76
0.22
1.9
1.5
—
—
—
0
0
5
41
1.22
0.22
3.2
3.2
13.40
34.09
u/ml
—
5
41
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
100
1049
0.93
0.20
4.1
5.0
2.83
2.60
ug/l
0.12
87
943
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
15
129
1.17
0.17
1.4
1.3
—
—
—
0
0
35
323
1.09
0.15
10.9
7.7
—
—
—
0
0
291
2935
0.94
0.11
69.7
21.9
35.52
39.93
%
20.56
270
2745
291
2935
0.94
0.11
68.4
21.8
3.86
4.48
e12/l
35.09
286
2855
33
346
0.95
0.07
3.6
4.3
33.80
32.07
%
0.30
25
231
253
2549
0.97
0.06
5.0
4.5
1.44
1.45
mmol/l
0.09
224
2330
15
162
0.92
0.06
1.1
1.2
173.25
137.73
iu/ml
—
6
55
25
238
1.05
0.05
1.4
1.9
—
—
—
0
0
255
2542
1.01
0.01
4.9
4.7
6.07
6.01
mmol/l
0.22
222
2310
39
397
0.98
0.01
1.5
1.4
—
—
—
0
0
246
2467
0.99
0.01
4.7
4.0
1.28
1.27
mmol/l
0.04
215
2246
17
173
0.98
0.00
1.9
2.5
—
13.60
—
0
10
257
2573
1.00
0.00
5.0
4.5
4.22
4.57
mmol/l
5.31
230
2370
22
215
1.02
0.00
1.4
1.8
—
—
—
0
0
15
154
0.97
0.00
1.2
1.4
—
54.40
—
0
12
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
5.22
—
0
8
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.8
—
60.30
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_ACQHAEMOLYTICANAEMIANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIANAS | 3.114 [2.46, 3.95] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.071 |
During the follow-up period (1.1.1998 — 31.12.2019), 453 out of 959 females with D3_ACQHAEMOLYTICANAEMIANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ACQHAEMOLYTICANAEMIANAS | 3.138 [2.33, 4.22] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 359 out of 817 males with D3_ACQHAEMOLYTICANAEMIANAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_ACQHAEMOLYTICANAEMIANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.352% | 0.488% |
| 5 | 1.783% | 3.256% |
| 10 | 4.076% | 7.853% |
| 15 | 7.3% | 14.352% |
| 20 | 12.566% | 23.308% |
Relationships between endpoints
↥Index endpoint: D3_ACQHAEMOLYTICANAEMIANAS – Other and unspecified acquired haemolytic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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