No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
166 |
4. Check minimum number of eventsNone |
166 |
5. Include endpoints |
217 |
6. Filter based on genotype QC (FinnGen only) |
217 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D55-D59
- Name in latin
- Aliae anaemiae haemolyticae hereditariae
Similar endpoints
↥List of similar endpoints to
Other hereditary haemolytic anaemias
based on the number of shared cases.
Similar with more cases:
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2471 | 1228 | 1174 |
| Only index persons | 1959 | 1005 | 954 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 24.85 | 27.81 | 21.09 |
| Only index persons | 25.64 | 27.68 | 23.49 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 217 | 127 | 90 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 38.10 | 34.83 | 42.72 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 190
- Matched controls
- 1899
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D58.0
ICD-10 Finland
Hereditary spherocytosis
+∞
64.3
58
*
D58.2
ICD-10 Finland
Other haemoglobinopathies
+∞
63.1
57
*
28200
ICD-8 Finland
Hereditary haemolytic anaemias, Familial acholuric jaundice
+∞
31.1
29
*
D58.9
ICD-10 Finland
Hereditary haemolytic anaemia, unspecified
+∞
19.1
18
*
2820A
ICD-9 Finland
Hereditary haemolytic anaemias, Hereditary spherocytosis
+∞
16.9
16
*
D64.9
ICD-10 Finland
Anaemia, unspecified
6.2
11.7
32
60
D58.1
ICD-10 Finland
Hereditary elliptocytosis
+∞
11.6
11
*
D58.8
ICD-10 Finland
Other specified hereditary haemolytic anaemias
+∞
11.6
11
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
5.5
11.3
34
72
JMA11
NOMESCO Finland
Laparoscopic total splenectomy
+∞
10.5
10
*
28299
ICD-8 Finland
Hereditary haemolytic anaemias, Other
+∞
8.4
8
*
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
7.3
7
*
JMA10
NOMESCO Finland
Transabdominal total splenectomy
31.3
7.2
9
*
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
3.7
6.9
30
92
D75.1
ICD-10 Finland
Secondary polycythaemia
41.6
6.8
8
*
WW500
NOMESCO Finland
Blood transfusion
6.4
6.5
16
27
Mortality – FinRegistry
↥Association
Association between endpoint D3_HEREDHAEMOLYTICANAEMIAOTHER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDHAEMOLYTICANAEMIAOTHER | 2.308 [1.7, 3.13] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.442 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 731 females with D3_HEREDHAEMOLYTICANAEMIAOTHER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HEREDHAEMOLYTICANAEMIAOTHER | 2.124 [1.51, 2.99] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 684 males with D3_HEREDHAEMOLYTICANAEMIAOTHER died.
Mortality risk
Mortality risk for people of age
years, who have D3_HEREDHAEMOLYTICANAEMIAOTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.155% | 0.381% |
| 5 | 1.246% | 2.119% |
| 10 | 3.404% | 5.639% |
| 15 | 6.755% | 10.52% |
| 20 | 11.738% | 17.51% |
Relationships between endpoints
↥Index endpoint: D3_HEREDHAEMOLYTICANAEMIAOTHER – Other hereditary haemolytic anaemias
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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