Hereditary spherocytosis

D3_HERESPHERO

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D58.0 Hospital discharge: ICD-9 — 2820A Hospital discharge: ICD-8 — 2820 Cause of death: ICD-10 — D58.0 Cause of death: ICD-9 — 2820A Cause of death: ICD-8 — 2820 2 out of 7 registries used, show all original rules.	101
4. Check minimum number of events None	101
5. Include endpoints None	101
6. Filter based on genotype QC (FinnGen only)	99

Control definitions (FinnGen only)

Control exclude: D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D58
Name in latin: Sphaerocytosis hereditaria

NAME	D3_HERESPHERO
CONTROL_EXCLUDE	D3_HAEMOLYTICANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D580
HD_ICD_9	2820A
HD_ICD_8	2820
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D580
COD_ICD_9	2820A
COD_ICD_8	2820
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hereditary spherocytosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1328	648	674
Only index persons	1089	542	547
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	12.11	13.89	10.13
Only index persons	13.65	15.91	11.41

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	99	57	42
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	25.70	24.56	27.24

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
101: Matched controls
1010

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D58.0

ICD-10 Finland

Hereditary spherocytosis

+∞

86.2

28200

ICD-8 Finland

Hereditary haemolytic anaemias, Familial acholuric jaundice

+∞

36.7

2820A

ICD-9 Finland

Hereditary haemolytic anaemias, Hereditary spherocytosis

+∞

19.4

JMA11

NOMESCO Finland

Laparoscopic total splenectomy

+∞

11.7

JMA10

NOMESCO Finland

Transabdominal total splenectomy

97.9

8.6

JKA21

NOMESCO Finland

Laparoscopic cholecystectomy

4.5

7.4

K80.2

ICD-10 Finland

Calculus of gallbladder without cholecystitis

4.3

6.9

6753

FHL

Transabdominal splenectomy

+∞

6.3

O99.1

ICD-10 Finland

Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023520) Reticulocytes [#/volume] in Blood

9.77

24.28

5.7

3.0

159.80

74.49

e9/l

6.75

(3000093) Morphology [Interpretation] in Blood Narrative

19.20

8.30

1.3

1.7

—

(3006315) Basophils [#/volume] in Blood

405

3.08

6.63

6.4

5.8

0.06

0.04

e9/l

3.94

359

(3001604) Monocytes [#/volume] in Blood

405

3.08

6.63

6.4

5.8

0.80

0.58

e9/l

2.76

362

(3013650) Neutrophils [#/volume] in Blood by Automated count

475

3.25

6.50

8.9

9.3

5.07

4.02

e9/l

2.21

421

(3013115) Eosinophils [#/volume] in Blood

419

3.04

6.41

6.6

0.21

0.20

e9/l

0.29

379

(3019198) Lymphocytes [#/volume] in Blood

420

3.03

6.37

6.5

5.9

2.30

1.95

e9/l

1.80

381

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

8.11

6.15

1.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

389

2.88

6.09

7.0

6.1

—

(3021960) Folate [Moles/volume] in Serum or Plasma

166

2.47

4.06

2.2

1.5

22.25

23.76

nmol/l

0.20

139

(40758558) Short blood count panel - Blood

204

2.38

4.05

4.2

6.8

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

5.38

3.46

1.7

7.3

141.78

152.22

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

275

2.15

3.42

2.2

1.8

98.75

96.11

pmol/l

0.16

140

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

324

2.08

3.21

4.9

6.0

1.22

mmol/l

0.04

299

(3015377) Calcium [Moles/volume] in Serum or Plasma

247

2.11

3.19

2.4

3.2

2.38

2.36

mmol/l

0.49

220

(3021589) Normoblasts [#/volume] in Blood

363

2.05

3.11

8.4

7.9

0.00

e9/l

0.55

292

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

7.00

2.91

1.3

1.1

108.33

87.22

—

(3022145) Colonoscopy Study observation

2.57

2.64

1.5

1.3

—

(3026493) Urate [Moles/volume] in Serum or Plasma

188

2.03

2.59

2.0

2.8

344.81

4781.78

umol/l

0.79

165

(3036489) Thrombin time

3.42

2.37

1.6

4.9

21.56

20.18

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.42

2.37

1.4

5.5

93.00

99.04

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

4.10

2.29

1.0

1.1

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.10

2.29

1.3

2.4

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

117

2.13

2.29

3.3

2.4

2.44

2.43

mmol/l

0.07

(3004588) Protein electrophoresis panel - Serum or Plasma

3.06

2.28

1.7

2.3

—

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

2.42

2.24

6.7

6.0

5.29

5.06

kpa

0.45

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

575

1.88

2.14

10.3

7.1

74.44

80.22

u/l

0.92

535

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.34

1.99

9.1

7.0

105.50

103.74

mmol/l

1.15

(3012544) pH of Venous blood

2.27

1.98

1.5

6.7

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

126

1.95

1.87

1.5

1.9

344.77

449.74

pmol/l

1.66

103

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

158

1.87

1.86

2.0

2.3

1.13

0.79

mg/l

0.39

121

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.50

1.85

1.5

6.4

24.27

23.87

mmol/l

0.15

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

261

1.73

1.82

2.0

3.5

—

(3034770) Mitochondria Ab [Titer] in Serum

3.47

1.77

1.5

1.3

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.26

1.74

2.8

10.87

9.81

g/l

0.63

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

605

1.75

1.70

3.3

3.9

14.56

14.65

pmol/l

0.13

549

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

3.29

1.69

1.3

1.6

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.29

1.69

1.5

1.6

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

349

1.65

5.7

7.1

1.21

1.22

mmol/l

0.56

295

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

3.70

1.63

1.0

1.1

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

314

1.64

1.61

2.2

2.7

73.72

74.75

nmol/l

0.10

278

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.12

1.60

1.7

1.8

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

361

1.63

1.59

4.6

2.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.45

1.54

2.0

2.4

—

(3030467) Casts [#/volume] in Urine by Automated count

210

1.69

1.53

2.1

3.5

0.15

0.20

e6/l

0.24

161

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.57

1.52

9.3

6.9

0.88

0.65

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.50

1.50

9.3

6.7

2.37

1.64

—

(3022217) INR in Platelet poor plasma by Coagulation assay

320

1.60

1.46

8.3

10.2

1.06

1.17

inr

1.46

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.23

1.45

1.2

1.1

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

3.23

1.45

6.4

4.2

6.80

9.28

u/ml

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

2.71

1.39

1.5

1.1

0.50

3.00

e6/l

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.04

1.37

1.0

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.04

1.37

1.0

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.20

1.34

1.3

1.7

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.20

1.34

1.4

1.8

—

(1761868) Lipid panel - Serum or Plasma

312

0.59

1.34

1.7

2.7

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.39

1.30

1.5

2.0

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.87

1.30

1.0

1.4

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.87

1.30

1.0

1.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.08

1.27

4.3

9.0

24.15

24.73

mmol/l

0.20

(3002523) Influenza virus A Ag [Presence] in Specimen

2.49

1.26

1.3

1.1

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.49

1.26

1.5

1.7

—

(3003740) Influenza virus B Ag [Presence] in Specimen

2.49

1.26

1.3

1.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.49

1.26

1.5

1.8

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

127

1.72

1.23

1.2

1.3

14.91

5.94

u/ml

—

(3044290) Cell count panel - Cerebral spinal fluid

2.71

1.23

1.4

1.2

—

(3019060) Gas panel - Arterial blood

2.20

1.21

3.6

4.3

—

(3002582) Erythrocytes [#/volume] in Urine

240

1.56

1.20

2.1

3.5

11.09

48.50

e6/l

0.86

188

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.57

1.16

2.0

1.8

—

(3042936) Bacteria identified in Isolate by Culture

1.77

1.15

2.0

1.6

—

(36304419) Bacteria [Presence] in Urine

216

1.55

1.14

2.1

3.2

—

(3052851) Hemolysis interference index of Serum or Plasma

2.45

1.10

2.4

3.5

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.80

1.08

8.1

6.2

—

(3000991) Gas panel - Venous blood

1.87

1.06

6.9

8.3

—

(40761535) Cells panel - Urine sediment

2.00

1.05

1.9

4.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.14

1.05

8.4

—

(3013707) Erythrocyte sedimentation rate by Westergren method

587

1.48

1.04

4.7

3.7

11.67

9.85

mm/h

0.41

544

(40768804) Tissue Pathology biopsy report

306

1.45

0.97

1.8

2.0

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.77

0.97

1.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

188

1.52

0.96

1.6

1.5

2.24

2.48

g/l

0.25

114

(3026782) Osmolality of Urine

145

1.57

0.95

1.4

2.9

479.81

568.42

mosm/kgh2o

0.94

123

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

128

1.60

0.94

2.4

3.6

0.83

2.53

e6/l

1.15

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.74

0.93

1.8

1.7

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.76

0.90

1.3

1.8

—

(3023368) Bacteria identified in Blood by Culture

182

1.50

0.89

5.4

4.0

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

862

1.75

0.87

16.3

13.2

65.24

72.72

umol/l

4.11

862

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.99

0.86

1.2

1.4

—

(4200892) Spirometry reversibility

1.80

0.85

1.4

1.3

—

(3000492) Spirometry study

1.67

0.83

1.2

1.4

—

(4035726) Immunohistochemistry procedure

1.72

0.79

1.4

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.81

0.77

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.70

0.76

1.3

1.6

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.14

0.75

2.4

1.2

—

(40768797) Stomach Pathology biopsy report

101

1.57

0.75

1.5

1.2

—

(3008898) HLA-B27 [Presence]

1.72

0.70

1.1

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.89

0.69

2.2

1.3

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

174

1.42

0.68

3.2

4.0

—

(3045414) Leukocytes [Presence] in Urine

1.83

0.67

1.4

1.5

—

(3044889) 12 lead EKG panel

511

1.32

0.64

3.2

3.4

—

(3018095) Leukocytes [#/volume] in Urine

278

1.34

0.63

3.2

4.3

165.49

22.89

e6/l

0.58

201

(3002256) Pathology report gross observation

1.51

0.63

1.1

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

149

0.64

0.62

1.5

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.53

0.61

1.7

2.1

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.76

0.59

1.7

5.7

135.67

127.43

g/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.60

0.55

2.5

1.8

—

(3019225) pH of Specimen

1.57

0.55

3.1

5.2

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

127

1.41

0.54

3.1

4.6

0.83

0.81

mmol/l

0.54

120

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

120

1.40

0.50

1.7

1.9

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.56

0.49

1.0

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

184

1.32

0.49

3.0

2.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

112

1.40

0.48

2.8

2.3

0.85

0.66

ug/l

—

(3003694) ABO and Rh group [Type] in Blood

251

1.28

0.47

1.6

1.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

131

1.36

0.46

2.5

3.5

0.60

0.81

e6/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

205

1.29

0.45

1.6

1.7

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.46

0.44

1.5

1.2

143.13

153.87

u/ml

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.64

0.43

1.4

—

(3003338) MCHC [Mass/volume]

754

1.29

0.43

21.7

15.2

346.06

333.86

g/l

11.66

749

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.4

—

17.09

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

841

1.36

0.41

17.0

11.9

19.90

21.43

mg/l

0.22

639

(3011288) Drugs identified in Urine by Screen method

1.49

0.41

1.8

1.6

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.40

0.0

1.2

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

735

1.27

0.40

4.3

4.4

1.76

1.85

mu/l

0.34

679

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.39

0.0

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

172

1.28

0.38

1.5

1.8

—

(40761511) CBC panel - Blood by Automated count

866

1.36

0.36

15.2

11.2

—

(1002224) Polysomnography panel

1.46

0.36

1.3

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.46

0.36

1.2

1.3

—

(3026008) Bacteria identified in Urine by Culture

219

0.78

0.36

3.3

3.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

176

0.76

0.35

1.6

2.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

250

1.22

0.35

2.6

3.4

15.78

44.62

ng/l

0.89

154

(3021601) Nitrite [Presence] in Urine by Test strip

386

1.20

0.34

4.3

5.3

0.00

estimate

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

751

1.24

0.33

2.8

3.6

1.24

1.29

mmol/l

0.22

692

(3017143) Hepatitis C virus Ab [Presence] in Serum

131

1.26

0.29

1.5

1.7

—

(36660697) Celiac disease serology panel - Serum

1.35

0.29

1.0

1.1

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.35

0.29

1.6

1.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

160

0.78

0.28

1.7

2.1

—

(21494755) Public health laboratory ask at order entry panel

1.30

0.28

1.3

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

151

1.23

0.27

3.9

4.3

23.36

20.99

—

(3009261) Glucose [Presence] in Urine by Test strip

393

1.16

0.27

2.9

3.8

0.00

estimate

—

(3013512) EKG study

190

1.20

0.26

3.1

3.4

—

(3044640) Blood type and Crossmatch panel - Blood

248

1.18

0.25

3.1

2.3

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.27

0.24

3.2

7.7

1.08

1.18

mmol/l

0.58

(3012516) Albumin [Mass/volume] in Urine

163

1.20

0.24

3.3

3.4

21.44

139.78

mg/l

1.50

100

(3000494) Fungus identified in Specimen by Culture

0.74

0.23

1.3

1.4

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.33

0.23

1.2

1.4

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.33

0.23

1.2

1.4

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.33

0.23

1.2

1.4

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.33

0.23

1.2

1.4

—

(3035350) Ketones [Presence] in Urine by Test strip

387

1.15

0.23

2.9

3.7

0.00

estimate

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.23

0.22

1.0

1.7

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.26

0.22

1.2

1.6

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.20

0.22

1.2

1.6

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.2

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

6.0

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.6

—

114.67

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

119.44

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.28

0.21

5.1

2.1

441.80

373.53

nmol/l

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.21

0.0

1.0

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.5

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.2

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.2

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.22

0.18

1.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

235

0.87

0.18

2.0

3.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

775

1.16

0.18

3.3

3.9

1.30

1.48

mmol/l

3.65

721

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

130

0.83

0.17

1.5

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

737

1.13

0.15

14.3

10.6

99.17

89.47

ml/min/173m2

4.32

590

(46235355) HIV 1 and 2 tests - Meaningful Use set

221

1.11

0.12

1.7

2.1

—

(3029937) Albumin [Presence] in Urine by Test strip

204

1.10

0.09

2.5

3.8

0.00

estimate

—

(3016879) Cocaine [Presence] in Urine

1.04

0.09

1.4

1.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

553

1.07

0.08

4.6

4.5

—

(3022621) pH of Urine by Test strip

0.80

0.08

1.8

2.0

—

(40761536) Microorganisms panel - Urine sediment

1.03

0.08

2.3

3.1

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.85

0.08

1.3

1.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.09

0.08

2.9

3.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

131

0.90

0.06

1.4

1.7

—

(3020682) Albumin/Creatinine [Ratio] in Urine

172

1.06

0.02

3.7

3.9

4.25

16.13

mg/mmol

1.04

100

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

694

1.03

0.00

4.3

4.7

29.89

38.50

mmol/mol

8.57

655

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

649

1.00

0.00

4.3

3.6

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

735

0.98

0.00

3.7

3.9

5.74

5.79

mmol/l

0.18

683

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

304

0.98

0.00

2.5

3.6

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.3

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.5

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

1.01

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

16.2

—

1989.33

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.3

—

1011.38

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

7.6

—

979.33

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.4

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.5

—

(3027008) Opiates [Presence] in Urine

0.92

-0.00

1.4

1.5

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.7

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

-0.00

0.0

1.6

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

0.33

—

(3020491) Glucose [Moles/volume] in Blood

0.00

-0.00

0.0

1.3

—

5.84

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

2.1

—

7.01

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.92

-0.00

1.0

1.2

—

113.93

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

213.83

—

(3042891) Cardiolipin IgM Ab [Mass/volume] in Serum

0.00

-0.00

0.0

1.2

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

-0.00

0.0

1.0

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.2

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.84

-0.00

1.2

1.4

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

11.62

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.94

-0.00

4.4

3.8

1.28

1.23

mmol/l

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

2.7

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.5

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.8

—

56.20

—

(40761995) Spermatozoa Progressive [#/volume] in Semen

0.00

-0.00

0.0

3.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

2.7

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

1.3

—

(3022313) Gas panel - Capillary blood

0.86

-0.00

2.2

5.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3000764) Benzodiazepines [Presence] in Urine

0.92

-0.00

1.4

1.5

—

(3028300) Cannabinoids [Presence] in Urine

0.92

-0.00

1.4

1.5

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

3.2

—

106.00

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3025941) Bacteria identified in Stool by Culture

0.92

-0.00

1.2

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3002619) Bacteria identified in Specimen by Culture

0.00

-0.00

0.0

1.0

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.4

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.0

—

142.20

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.5

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

-0.00

0.0

2.3

—

(3014043) Spermatozoa Nonprogressive/100 spermatozoa in Semen

0.00

-0.00

0.0

6.0

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

1.47

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3027944) Amphetamines [Presence] in Urine

0.92

-0.00

1.4

1.5

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

1.2

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

-0.00

0.0

1.9

—

42.43

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

1649.20

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_HERESPHERO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_HERESPHERO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_HERESPHERO – Hereditary spherocytosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hereditary spherocytosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints