Hereditary spherocytosis

D3_HERESPHERO

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D58.0 Hospital discharge: ICD-9 — 2820A Hospital discharge: ICD-8 — 2820 Cause of death: ICD-10 — D58.0 Cause of death: ICD-9 — 2820A Cause of death: ICD-8 — 2820 2 out of 7 registries used, show all original rules.	100
4. Check minimum number of events None	100
5. Include endpoints None	100
6. Filter based on genotype QC (FinnGen only)	100

Control definitions (FinnGen only)

Control exclude: D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D58
Name in latin: Sphaerocytosis hereditaria

NAME	D3_HERESPHERO
CONTROL_EXCLUDE	D3_HAEMOLYTICANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D580
HD_ICD_9	2820A
HD_ICD_8	2820
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D580
COD_ICD_9	2820A
COD_ICD_8	2820
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Hereditary spherocytosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1328	648	674
Only index persons	1089	542	547
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.02
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	12.11	13.89	10.13
Only index persons	13.65	15.91	11.41

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	100	57	43
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	26.11	24.56	28.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
88: Matched controls
878

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D58.0

ICD-10 Finland

Hereditary spherocytosis

+∞

70.5

28200

ICD-8 Finland

Hereditary haemolytic anaemias, Familial acholuric jaundice

+∞

32.3

2820A

ICD-9 Finland

Hereditary haemolytic anaemias, Hereditary spherocytosis

+∞

17.2

JMA11

NOMESCO Finland

Laparoscopic total splenectomy

+∞

9.5

JMA10

NOMESCO Finland

Transabdominal total splenectomy

86.9

7.5

6753

FHL

Transabdominal splenectomy

+∞

6.3

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023520) Reticulocytes [#/volume] in Blood

9.82

24.30

5.7

3.0

159.8

74.5

e9/l

6.75

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

7.44

7.79

1.7

—

(3000093) Morphology [Interpretation] in Blood Narrative

17.43

7.42

1.4

1.7

—

(3001604) Monocytes [#/volume] in Blood

400

3.05

6.47

6.4

5.8

0.8

0.6

e9/l

2.76

356

(3006315) Basophils [#/volume] in Blood

401

3.03

6.43

6.4

5.8

0.1

0.0

e9/l

3.69

356

(3013650) Neutrophils [#/volume] in Blood by Automated count

472

3.18

6.25

9.0

9.3

5.1

4.0

e9/l

2.28

418

(3013115) Eosinophils [#/volume] in Blood

415

3.00

6.21

6.6

0.2

e9/l

0.31

376

(3019198) Lymphocytes [#/volume] in Blood

415

3.00

6.21

6.5

5.8

2.3

2.0

e9/l

1.81

375

(42870588) Differential panel, method unspecified - Blood

260

2.63

5.28

6.5

5.9

—

(40758558) Short blood count panel - Blood

202

2.42

4.17

4.2

6.7

—

(3021960) Folate [Moles/volume] in Serum or Plasma

165

2.38

3.70

2.2

1.5

22.7

23.7

nmol/l

0.12

138

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

273

2.18

3.51

2.2

1.8

98.7

96.1

pmol/l

0.16

139

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

5.38

3.46

1.7

7.3

141.8

152.2

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

323

2.10

3.26

4.9

6.0

1.2

mmol/l

0.02

296

(3021589) Normoblasts [#/volume] in Blood

360

2.09

3.23

8.4

7.9

0.0

e9/l

0.55

290

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

7.00

2.91

1.3

1.1

108.3

87.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

247

2.03

2.87

2.4

3.2

2.4

mmol/l

1.00

219

(3026493) Urate [Moles/volume] in Serum or Plasma

186

2.06

2.67

2.0

2.7

344.8

4892.5

umol/l

0.79

161

(3022145) Colonoscopy Study observation

2.57

2.64

1.5

1.3

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

4.34

2.40

1.3

2.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.06

2.38

1.7

2.3

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

3.43

2.37

1.4

5.5

93.0

99.0

—

(3036489) Thrombin time

3.43

2.37

1.6

4.9

21.6

20.2

—

(3032080) INR in Blood by Coagulation assay

261

1.89

2.37

5.3

7.9

1.1

1.2

inr

1.38

(4306422)

4.83

2.30

1.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

4.10

2.29

1.0

1.1

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

117

2.13

2.29

3.3

2.4

mmol/l

0.08

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

2.42

2.24

6.7

6.0

5.3

5.1

kpa

0.45

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

569

1.85

2.05

10.4

7.2

74.9

80.4

u/l

0.85

530

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

154

1.93

2.02

2.0

2.3

1.1

0.8

mg/l

0.38

118

(3012544) pH of Venous blood

2.27

1.98

1.5

6.7

—

(3034770) Mitochondria Ab [Titer] in Serum

3.68

1.86

1.5

1.2

—

(3005719) IgG [Mass/volume] in Serum or Plasma

2.30

1.81

2.8

10.9

9.8

g/l

0.64

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.48

1.77

1.5

1.7

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

3.48

1.77

1.3

1.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

348

1.66

1.69

5.7

7.1

1.2

mmol/l

0.62

293

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

2.93

1.68

1.4

1.8

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

313

1.66

1.64

2.2

2.7

73.7

74.8

nmol/l

0.11

277

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

3.70

1.63

1.0

1.1

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

599

1.72

1.62

3.3

3.9

14.6

14.7

pmol/l

0.16

543

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

260

1.67

1.61

2.0

3.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.12

1.60

1.7

1.8

—

(3030467) Casts [#/volume] in Urine by Automated count

209

1.70

1.56

2.1

3.5

0.1

0.2

e6/l

0.24

159

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

126

1.84

1.56

1.5

1.9

356.9

449.7

pmol/l

1.40

103

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.45

1.54

2.0

2.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

2.57

1.52

9.3

6.9

0.9

0.6

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.50

1.50

9.3

6.7

2.4

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

357

1.60

1.48

7.9

4.1

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

3.23

1.45

1.2

1.1

—

(3031040) Bacteria [#/volume] in Urine by Automated count

507

1.59

1.40

4.4

4.6

—

462.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

189

1.67

1.39

4.9

4.1

—

(3016543) Leukocytes [#/volume] in Cerebral spinal fluid

2.71

1.39

1.5

1.1

0.5

3.0

e6/l

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

3.04

1.37

1.0

1.2

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.04

1.37

1.0

1.4

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.04

1.37

1.0

1.4

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.20

1.34

1.3

1.7

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

2.20

1.34

1.4

1.8

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

124

1.77

1.33

1.2

1.3

14.9

6.0

u/ml

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.47

1.32

1.5

2.0

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.59

1.32

1.5

1.8

—

(1761868) Lipid panel - Serum or Plasma

310

0.59

1.31

1.7

2.7

—

(3044290) Cell count panel - Cerebral spinal fluid

2.87

1.30

1.4

1.1

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.87

1.30

1.0

1.4

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.08

1.27

4.3

9.0

24.2

24.7

mmol/l

0.20

(3003740) Influenza virus B Ag [Presence] in Specimen

2.49

1.26

1.3

1.1

—

(3002523) Influenza virus A Ag [Presence] in Specimen

2.49

1.26

1.3

1.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

2.71

1.23

2.0

1.8

—

(3019060) Gas panel - Arterial blood

2.20

1.21

3.6

4.3

—

(36304419) Bacteria [Presence] in Urine

215

1.56

1.16

2.1

3.2

—

(3042936) Bacteria identified in Isolate by Culture

1.77

1.15

2.0

1.6

—

(3052851) Hemolysis interference index of Serum or Plasma

2.45

1.10

2.6

3.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.80

1.08

8.1

6.2

—

(3000991) Gas panel - Venous blood

1.87

1.06

6.9

8.3

—

(40761535) Cells panel - Urine sediment

2.00

1.05

1.9

4.4

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.14

1.05

8.4

—

(40768804) Tissue Pathology biopsy report

303

1.47

1.03

1.8

2.0

—

(3002582) Erythrocytes [#/volume] in Urine

239

1.50

1.02

2.2

3.6

11.4

48.7

e6/l

0.85

187

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.79

1.01

1.6

—

(3026782) Osmolality of Urine

143

1.59

1.00

1.4

2.7

479.8

569.3

mosm/kgh2o

0.95

121

(3007164) IgA [Mass/volume] in Serum or Plasma

187

1.53

0.99

1.6

1.5

2.2

2.5

g/l

0.25

113

(3013707) Erythrocyte sedimentation rate by Westergren method

581

1.46

0.98

4.7

3.8

11.8

9.9

mm/h

0.44

539

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.77

0.97

1.8

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

128

1.60

0.95

2.4

3.6

0.8

2.5

e6/l

1.15

(3023368) Bacteria identified in Blood by Culture

180

1.52

0.94

5.4

4.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.76

0.90

1.3

1.8

—

(3000492) Spirometry study

1.72

0.90

1.2

1.3

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

854

1.73

0.87

16.4

13.3

65.3

72.9

umol/l

4.14

854

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.99

0.86

1.2

1.4

—

(4010399)

1.80

0.85

1.4

1.3

—

(4035726)

1.72

0.79

1.4

1.3

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

1.81

0.77

1.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.23

0.77

2.4

1.2

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.70

0.76

1.3

1.6

—

(40768797) Stomach Pathology biopsy report

101

1.57

0.75

1.5

1.2

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

172

1.44

0.72

3.2

4.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.97

0.71

2.2

1.3

—

(3009542) Hematocrit [Volume Fraction] of Blood

790

1.51

0.70

19.4

12.6

39.9

40.5

0.40

636

(3008898) HLA-B27 [Presence]

1.72

0.70

1.1

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.67

0.68

1.0

1.7

—

(3045414) Leukocytes [Presence] in Urine

1.83

0.67

1.4

1.5

—

(3002256) Pathology report gross observation

1.52

0.63

1.1

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

149

0.63

0.62

1.5

1.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.70

0.62

1.4

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.53

0.61

1.8

2.1

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

0.00

0.59

0.0

4.2

—

23.2

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.76

0.59

1.7

5.7

135.7

127.4

g/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

180

1.36

0.56

3.0

2.4

—

(3044889) 12 lead EKG panel

508

1.28

0.55

3.2

3.4

—

(3019225) pH of Specimen

1.57

0.55

3.1

5.2

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

118

1.42

0.54

1.7

1.9

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

127

1.41

0.54

3.1

4.6

0.8

mmol/l

0.54

120

(3018095) Leukocytes [#/volume] in Urine

275

1.30

0.53

3.3

4.4

172.3

23.0

e6/l

0.58

200

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

112

1.40

0.48

2.8

2.3

0.8

0.7

ug/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

131

1.36

0.46

2.5

3.5

0.6

0.8

e6/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.62

0.45

2.5

1.8

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.49

0.44

1.5

1.2

143.1

148.5

u/ml

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.41

0.0

3.4

—

17.1

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.2

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

1.49

0.41

1.2

1.3

—

(3011288) Drugs identified in Urine by Screen method

1.49

0.41

1.8

1.6

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

1.49

0.41

1.2

1.3

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

1.49

0.41

1.2

1.3

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

1.49

0.41

1.2

1.3

—

(3003694) ABO and Rh group [Type] in Blood

246

1.25

0.40

1.6

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

746

1.28

0.40

2.8

3.6

1.2

1.3

mmol/l

0.23

687

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.40

0.0

1.3

—

(3003338) MCHC [Mass/volume]

747

1.27

0.39

21.8

15.2

345.8

333.9

g/l

11.30

742

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

833

1.34

0.38

17.1

11.9

20.2

21.4

mg/l

0.17

633

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

727

1.26

0.38

4.3

4.4

1.8

1.9

mu/l

0.36

671

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

248

1.24

0.37

2.6

3.4

15.8

45.0

ng/l

0.90

152

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

201

1.26

0.37

1.7

—

(1002224) Polysomnography panel

1.46

0.36

1.3

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.46

0.36

1.2

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

128

1.30

0.34

1.5

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

166

1.26

0.33

1.5

1.7

—

(40761511) CBC panel - Blood by Automated count

859

1.33

0.32

15.3

11.3

—

(36660697) Celiac disease serology panel - Serum

1.37

0.31

1.0

1.1

—

(3026008) Bacteria identified in Urine by Culture

215

0.80

0.31

3.3

3.1

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

172

0.78

0.30

1.6

2.3

—

(21494755) Public health laboratory ask at order entry panel

1.31

0.29

1.3

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.35

0.29

1.6

1.9

—

(3041096) Erythrocytes [Presence] in Urine by Automated

234

0.82

0.28

2.1

3.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

151

1.23

0.27

3.9

4.3

23.4

21.0

—

(3021601) Nitrite [Presence] in Urine by Test strip

383

1.17

0.27

4.4

5.3

0.0

estimate

—

(3013512) EKG study

190

1.20

0.26

3.1

3.4

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

157

0.80

0.24

1.7

2.1

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

1.27

0.24

3.2

7.7

1.1

1.2

mmol/l

0.58

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

770

1.19

0.24

3.3

3.9

1.3

1.5

mmol/l

3.60

715

(3000494) Fungus identified in Specimen by Culture

0.75

0.23

1.3

1.4

—

(3019145) Choriogonadotropin.beta subunit free [Mass/volume] in Serum or Plasma

1.33

0.23

1.2

1.6

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

1.26

0.23

1.0

1.7

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.21

0.0

6.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.2

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

119.4

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.6

—

114.7

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.21

0.0

1.0

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

1.5

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.2

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.21

0.0

1.0

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.2

—

(3009261) Glucose [Presence] in Urine by Test strip

390

1.13

0.20

3.0

3.8

0.0

estimate

—

(3044640) Blood type and Crossmatch panel - Blood

244

1.15

0.19

3.2

2.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.22

0.18

1.0

—

(3015736) pH of Urine

295

1.12

0.16

3.1

3.8

—

(3035350) Ketones [Presence] in Urine by Test strip

384

1.11

0.16

2.9

3.7

0.0

estimate

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.14

0.15

5.4

2.1

435.3

373.5

nmol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

546

1.10

0.14

4.6

4.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

127

0.85

0.13

1.5

—

(3012516) Albumin [Mass/volume] in Urine

163

1.13

0.11

3.4

23.1

141.9

mg/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.17

0.10

1.2

1.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

124

0.87

0.09

1.5

1.7

—

(3016879) Cocaine [Presence] in Urine

1.07

0.09

1.4

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

214

1.10

0.09

1.8

2.1

—

(3022621) pH of Urine by Test strip

0.80

0.08

1.8

2.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

1.10

0.08

1.3

1.5

—

(40761536) Microorganisms panel - Urine sediment

1.05

0.08

2.3

3.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.09

0.08

2.9

3.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

303

0.94

0.06

2.6

3.6

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

729

1.06

0.04

14.4

10.7

99.2

89.2

ml/min/173m2

4.35

582

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

731

0.95

0.04

3.8

4.0

5.7

5.8

mmol/l

0.16

679

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

641

1.04

0.02

4.3

3.6

—

(3029937) Albumin [Presence] in Urine by Test strip

203

1.04

0.01

2.6

3.8

0.0

estimate

—

(3020682) Albumin/Creatinine [Ratio] in Urine

172

0.99

0.00

3.9

4.2

4.6

16.1

mg/mmol

—

100

(3025941) Bacteria identified in Stool by Culture

0.92

0.00

1.2

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.0

1.5

—

(3027944) Amphetamines [Presence] in Urine

0.94

0.00

1.4

1.5

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.0

1.3

—

(3051651) Icteric interference index of Serum or Plasma

0.00

0.0

2.5

—

(4211845)

0.00

0.0

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.84

0.00

1.2

1.4

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.0

2.3

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

2.7

—

(4024509)

0.00

0.0

1.0

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

0.0

1.5

—

11.6

—

(3018658) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.0

2.7

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.2

—

(3019497) Choriogonadotropin.beta subunit free [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.0

2.5

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.0

2.4

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(4281824)

0.00

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

690

1.00

0.00

4.4

4.7

30.2

38.5

mmol/mol

8.28

651

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.3

—

1011.4

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

3.8

—

56.2

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.0

16.2

—

1989.3

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

0.3

—

(40761995) Spermatozoa Progressive [#/volume] in Semen

0.00

0.0

3.0

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.0

2.5

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3022313) Gas panel - Capillary blood

0.85

0.00

2.2

5.0

—

(3033306) Mononuclear cells/100 leukocytes in Cerebral spinal fluid

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

0.0

2.7

—

(3027008) Opiates [Presence] in Urine

0.94

0.00

1.4

1.5

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.0

1.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.0

2.7

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.0

7.6

—

979.3

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3027238) Thyroperoxidase Ab [Units/volume] in Serum or Plasma

0.92

0.00

1.0

1.2

—

113.9

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

1.3

—

5.8

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

0.0

3.2

—

106.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(21494815) CD4 cells/100 lymphocytes in Specimen

0.00

0.0

1.9

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.3

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

0.0

1.6

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

0.94

0.00

4.4

3.8

1.3

1.2

mmol/l

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.6

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.1

—

(3014043) Spermatozoa Nonprogressive/100 spermatozoa in Semen

0.00

0.0

6.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

0.0

1.3

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1649.2

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

2.7

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.0

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.94

0.00

1.4

1.5

—

(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.0

—

142.2

—

(44806071)

0.00

0.0

1.2

—

(3028300) Cannabinoids [Presence] in Urine

0.94

0.00

1.4

1.5

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.0

2.0

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

3.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_HERESPHERO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have D3_HERESPHERO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: D3_HERESPHERO – Hereditary spherocytosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Hereditary spherocytosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints