No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
88 |
4. Check minimum number of eventsNone |
88 |
5. Include endpointsNone |
88 |
6. Filter based on genotype QC (FinnGen only) |
82 |
Control definitions (FinnGen only)
- Control exclude
- D3_HAEMOLYTICANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D59
- Name in latin
- Syndroma haemolytico-uraemicum
Similar endpoints
↥List of similar endpoints to
Haemolytic-uraemic syndrome
based on the number of shared cases.
Similar with more cases:
- Acquired haemolytic anaemia
- Haemolytic anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 569 | 325 | 242 |
| Only index persons | 445 | 258 | 187 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 25.46 | 26.20 | 24.21 |
| Only index persons | 25.69 | 26.59 | 24.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 82 | 46 | 36 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 37.73 | 31.37 | 45.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 88
- Matched controls
- 880
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.3
ICD-10 Finland
Haemolytic-uraemic syndrome
+∞
70.6
58
*
N08.2*D59.3
ICD-10 Finland
Glomerular disorders in haemolytic-uraemic syndrome
+∞
57.8
49
*
TK800
NOMESCO Finland
Hemodialysis
98.0
37.1
39
7
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
20.4
35.9
32
24
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
81.6
35.1
38
8
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
81.6
35.1
38
8
A11CC03
ATC
alfacalcidol; systemic
82.3
29.6
32
6
H02AB04
ATC
methylprednisolone; systemic
13.7
28.8
33
37
Z94.0
ICD-10 Finland
Kidney transplant status
141.6
28.7
29
*
A12AA04
ATC
calcium carbonate; oral
127.6
26.4
27
*
L04AA06
ATC
mycophenolic acid; systemic
80.7
25.8
28
5
127
Kela drug reimbursment
Transplant complication
60.5
25.5
29
7
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
120.9
25.2
26
*
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
+∞
25.2
23
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
40.4
24.3
30
11
Z49.1
ICD-10 Finland
Extracorporeal dialysis
72.6
23.6
26
5
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
9.0
23.3
41
78
C09AA02
ATC
enalapril; systemic
9.5
22.9
36
60
N18.0
ICD-10 Finland
End-stage renal disease
153.4
22.8
23
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
288.9
22.7
22
*
B03XA02
ATC
darbepoetin alfa; parenteral
51.7
22.3
26
7
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
255.0
20.5
20
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
8.6
20.4
34
60
C03CA01
ATC
furosemide; systemic
7.4
19.6
43
101
WW400
NOMESCO Finland
Plasmaferesis
+∞
19.5
18
*
L04AD02
ATC
tacrolimus; systemic
48.0
18.7
22
6
V03AE01
ATC
polystyrene sulfonate; oral
85.0
18.6
20
*
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
54.2
18.2
21
5
205
Kela drug reimbursment
Chronic hypertension
7.1
18.1
39
89
N08.2
ICD-10 Finland
Glomerular disorders in blood diseases and disorders involving the immune mechanism
+∞
17.2
16
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
55.8
15.7
18
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
69.2
15.4
17
*
C08CA01
ATC
amlodipine; oral
5.8
15.4
49
157
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
96.1
15.1
16
*
137
Kela drug reimbursment
Uraemia requiring dialysis
96.1
15.1
16
*
D89.80
ICD-10 Finland
Immunoglobulin A (IgA) deposits in organisms
+∞
15.0
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.9
15.0
58
218
Z49.0
ICD-10 Finland
Preparatory care for dialysis
178.4
15.0
15
*
Z2446
NOMESCO Finland
Social worker
7.3
14.6
26
48
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
20.7
14.3
21
13
Z3231
NOMESCO Finland
Registered nurse
5.4
14.1
48
160
KA1AE
NOMESCO Finland
Kidney ultrasound examination
34.5
13.5
17
6
C02AC05
ATC
moxonidine; oral
27.8
13.5
18
8
WX408
NOMESCO Finland
General anesthesy, balanced
5.2
13.4
43
136
L04AA01
ATC
[U] ciclosporin
82.1
13.0
14
*
N18.8
ICD-10 Finland
Other chronic renal failure
25.9
12.6
17
8
B03XA01
ATC
erythropoietin; parenteral
54.8
12.3
14
*
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
54.8
12.3
14
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
20.7
11.8
17
10
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
+∞
11.7
11
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
11.7
11
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
17.0
11.6
18
13
L04AD01
ATC
ciclosporin; systemic
29.7
11.6
15
6
V03AE02
ATC
sevelamer; oral
68.6
10.9
12
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
68.6
10.9
12
*
B05DB
ATC
Hypertonic solutions
124.2
10.7
11
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
124.2
10.7
11
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
13.8
10.6
18
16
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
10.6
10
*
R4110
NOMESCO Finland
Physiotherapy
4.3
10.3
40
142
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
11.2
10.2
19
21
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.5
10.2
19
36
ZX120
NOMESCO Finland
Intravenous
6.0
9.9
20
41
Z2221
NOMESCO Finland
Medical doctor
4.1
9.8
42
159
ZXA00
NOMESCO Finland
Right side
4.6
9.7
30
89
B05DA
ATC
Isotonic solutions
111.5
9.6
10
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.9
9.3
25
66
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
41.4
9.3
11
*
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
41.4
9.3
11
*
C07AG02
ATC
carvedilol; oral
13.6
9.0
15
13
ZXE00
NOMESCO Finland
One hour or less
3.9
9.0
53
247
ZXE10
NOMESCO Finland
More than one and less than three hours
3.9
9.0
45
188
ZXE20
NOMESCO Finland
More than three and less than five hours
4.9
9.0
24
63
Z3226
NOMESCO Finland
Physiotherapist
4.2
8.9
32
106
Z49.2
ICD-10 Finland
Other dialysis
99.2
8.6
9
*
N08.5*M31.1
ICD-10 Finland
Glomerular disorders in thrombotic thrombocytopenic purpura
+∞
8.5
8
*
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
+∞
8.5
8
*
ZXD05
NOMESCO Finland
Urgent procedure
3.7
8.4
43
181
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.7
8.1
37
143
M04AA01
ATC
allopurinol; systemic
5.4
8.1
18
40
H05BX01
ATC
cinacalcet; oral
49.6
7.9
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
4.0
7.7
28
92
196
Kela drug reimbursment
Paricalcitol and cinacalcet
87.1
7.5
8
*
RD210, ,
NOMESCO Finland
17.7
7.4
11
7
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
33.0
7.3
9
*
C07AB02
ATC
metoprolol; systemic
4.1
7.2
24
74
L04AA05
ATC
[U] tacrolimus
43.5
6.9
8
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
43.5
6.9
8
*
C02CA01
ATC
prazosin; oral
43.5
6.9
8
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
8.5
6.7
14
19
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
75.1
6.5
7
*
C08CA02
ATC
felodipine; oral
7.3
6.5
15
24
WX002
NOMESCO Finland
Sedation and analgesia
3.9
6.5
23
74
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
29.0
6.3
8
*
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
7.7
6.3
14
21
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
6.3
6
*
V03AE03
ATC
lanthanum carbonate; oral
+∞
6.3
6
*
A12AA12
ATC
[U] calcium acetate
+∞
6.3
6
*
PBU84
NOMESCO Finland
Plastic repair of arteriovenous fistula from artery of upper extremity
+∞
6.3
6
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
16.5
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
49
87
11.45
30.52
11.0
2.7
12.18
16.54
umol/l
2.27
49
78
35
58
9.36
22.30
20.3
4.8
23.40
23.31
mmol/l
0.06
35
58
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
10
36.13
20.60
5.3
9.4
0.26
0.33
u/ml
—
14
5
24
37
8.54
15.84
8.1
2.1
30.38
76.43
ml/min/173m2
—
8
14
47
144
5.86
15.57
12.3
3.8
29.48
16.94
mg/mmol
0.64
41
87
14
0
+∞
15.01
10.6
0.0
5.18
—
mmol/l
—
14
0
37
98
5.79
14.27
8.6
3.0
2.92
1.91
e6/l
0.26
26
58
52
186
5.39
14.05
12.8
2.9
0.22
0.31
e6/l
0.26
45
143
23
20
15.11
13.82
2.1
1.6
162.65
171.73
u/ml
0.06
17
11
58
230
5.46
13.73
13.8
3.0
—
—
—
0
0
23
21
14.39
13.53
2.0
1.4
—
—
—
0
0
37
105
5.35
13.05
8.5
2.9
0.51
0.78
e6/l
0.57
26
64
12
0
+∞
12.81
11.8
0.0
—
—
—
0
0
22
21
13.55
12.67
2.6
1.7
—
—
—
0
0
23
26
11.56
12.22
3.9
3.7
185.78
176.04
%
0.25
23
26
15
10
17.76
9.93
1.9
2.0
—
—
—
0
0
26
69
4.93
9.63
18.8
9.2
23.80
24.25
mmol/l
0.32
26
69
9
0
+∞
9.54
1.2
0.0
—
—
—
0
0
9
0
+∞
9.54
1.2
0.0
—
—
—
0
0
22
53
5.20
9.08
6.6
3.1
—
—
—
0
0
31
104
4.06
8.39
4.1
2.9
365.32
611.06
ng/l
0.30
25
70
24
67
4.55
8.27
19.0
7.8
103.75
104.24
mmol/l
0.14
24
67
11
5
24.81
8.24
1.2
1.0
—
—
—
0
0
38
149
3.73
8.19
3.1
2.0
—
—
—
0
0
18
27
8.09
8.11
2.7
1.5
—
—
—
0
0
18
27
8.09
8.11
2.2
1.6
—
—
—
0
0
13
11
13.61
7.87
2.2
2.0
—
—
—
0
0
13
13
11.50
7.32
2.5
1.2
3.17
1.60
u/ml
—
6
5
37
152
3.47
7.29
4.4
2.1
5.81
0.83
mg/l
0.98
32
119
12
11
12.40
7.04
3.7
2.4
—
—
—
0
0
13
15
9.95
6.83
2.5
1.2
6.00
3.67
u/ml
—
8
9
18
35
6.19
6.79
1.7
1.6
—
—
—
0
0
20
56
4.33
6.78
27.1
10.6
1.02
1.56
mmol/l
0.25
20
45
23
74
3.85
6.46
24.1
6.6
1.05
1.39
mmol/l
0.17
17
55
67
415
3.57
6.40
17.9
8.6
4.61
3.83
e9/l
1.25
61
371
11
11
11.22
6.23
1.1
1.1
—
—
—
0
0
13
18
8.26
6.19
17.8
23.7
24.31
24.51
mmol/l
0.08
13
18
22
72
3.74
6.00
3.2
1.7
—
—
—
0
0
62
378
3.17
5.86
20.5
5.2
7.19
6.33
mmol/l
0.93
57
343
16
43
4.33
5.66
4.0
3.0
0.23
0.22
g/l
0.10
16
43
22
75
3.58
5.63
3.4
1.8
—
—
—
0
0
54
318
2.81
5.22
12.0
5.9
17.01
18.11
umol/l
0.07
54
299
9
9
10.97
5.15
2.3
4.3
—
—
—
0
0
45
245
2.71
5.02
20.5
10.3
1.23
1.14
inr
—
9
68
25
99
3.13
5.02
4.0
1.8
—
—
—
0
0
8
8
10.84
4.62
1.3
1.3
—
—
—
0
0
51
306
2.59
4.54
4.0
2.5
—
—
—
0
0
12
25
5.38
4.37
1.8
1.3
—
—
—
0
0
7
6
12.52
4.35
1.3
1.7
—
—
—
0
0
7
6
12.52
4.35
1.3
1.7
—
—
—
0
0
7
6
12.52
4.35
1.3
1.7
—
—
—
0
0
7
6
12.52
4.35
1.3
1.7
—
—
—
0
0
7
6
12.52
4.35
1.3
1.7
—
—
—
0
0
39
213
2.49
4.15
2.0
1.8
97.60
95.16
pmol/l
0.12
20
113
17
62
3.16
3.85
19.4
7.0
23.45
24.57
mmol/l
0.91
17
62
6
5
12.73
3.82
4.0
7.8
104.83
99.20
%
—
6
5
52
339
2.31
3.56
10.1
3.4
0.00
0.00
estimate
-0.00
11
71
6
6
10.60
3.55
3.8
1.0
0.00
0.00
g/l
—
6
6
6
6
10.60
3.55
1.0
1.0
—
—
—
0
0
12
34
3.92
3.35
19.6
14.6
91.48
94.72
%
0.78
12
34
52
346
2.23
3.30
10.1
3.5
0.00
0.00
estimate
-0.00
11
63
7
11
6.80
3.25
3.6
1.2
—
—
—
0
0
7
11
6.80
3.25
3.0
1.3
—
—
—
0
0
51
339
2.20
3.22
14.5
4.9
0.00
0.00
estimate
-0.00
11
68
6
8
7.94
3.10
1.2
1.4
—
—
—
0
0
7
12
6.23
3.08
6.3
2.6
116.86
131.14
g/l
—
7
7
7
12
6.23
3.08
8.4
3.8
60.43
55.50
%
—
7
12
7
13
5.75
2.93
2.4
2.3
—
—
—
0
0
6
9
7.05
2.91
2.8
1.2
—
—
—
0
0
8
18
4.78
2.87
1.3
1.2
—
—
—
0
0
8
19
4.52
2.75
3.1
1.6
—
—
—
0
0
8
20
4.29
2.64
3.0
1.6
—
—
—
0
0
8
21
4.08
2.53
1.3
1.2
—
15.25
—
0
6
7
16
4.65
2.53
1.1
1.1
—
—
—
0
0
7
17
4.38
2.41
1.1
1.1
—
—
—
0
0
5
8
6.54
2.40
1.0
1.1
—
—
—
0
0
6
14
4.51
2.19
1.7
1.1
—
—
—
0
0
6
14
4.51
2.19
2.8
1.6
—
—
—
0
0
6
14
4.51
2.19
2.7
1.9
—
—
—
0
0
29
177
1.95
2.12
4.8
2.2
100.38
57.86
u/l
0.48
29
169
5
11
4.75
1.97
1.0
1.7
—
—
—
0
0
5
12
4.35
1.85
1.8
1.3
—
—
—
0
0
5
13
4.01
1.74
1.6
1.2
—
—
—
0
0
69
577
1.91
1.69
46.1
9.6
54.62
89.64
ml/min/173m2
8.72
57
443
5
15
3.47
1.54
1.4
1.1
—
—
—
0
0
5
15
3.47
1.54
1.4
1.1
—
—
—
0
0
6
22
2.85
1.46
1.5
2.8
—
—
—
0
0
30
210
1.65
1.33
7.9
3.1
44.50
31.88
u/l
0.80
30
197
25
167
1.69
1.32
2.4
1.7
1.52
1.43
mmol/l
0.21
25
147
5
110
0.42
1.23
1.0
1.3
—
7.02
—
0
47
78
707
1.91
1.10
48.7
11.0
17.75
20.97
mg/l
0.80
71
542
71
628
1.68
1.08
73.0
13.8
14.75
14.28
%
0.49
71
623
14
216
0.58
1.03
1.4
1.8
—
—
—
0
0
78
711
1.85
1.02
54.1
11.6
184.24
71.70
umol/l
5.80
78
711
0
28
0.00
0.99
0.0
1.3
—
—
—
0
0
8
45
1.85
0.87
1.3
1.2
—
—
—
0
0
54
466
1.41
0.79
5.9
3.1
34.83
35.10
u/l
0.01
54
449
0
21
0.00
0.61
0.0
1.3
—
—
—
0
0
6
35
1.77
0.59
1.7
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
18
150
1.25
0.29
1.6
1.5
—
—
—
0
0
61
576
1.19
0.27
4.0
4.0
—
—
—
0
0
5
38
1.33
0.23
1.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
50
1.21
0.20
1.7
1.5
—
—
—
0
0
14
161
0.84
0.17
1.4
2.4
—
—
—
0
0
22
198
1.15
0.16
5.8
3.8
94.76
29.47
ng/l
0.48
17
120
81
795
1.24
0.15
72.5
16.9
118.22
135.50
g/l
11.40
81
785
18
161
1.15
0.14
3.1
4.5
1.43
2.16
ug/l
1.01
18
145
13
148
0.86
0.13
1.2
2.2
—
—
—
0
0
24
258
0.90
0.11
11.5
3.4
—
—
—
0
0
5
48
1.04
0.09
1.6
1.5
—
—
—
0
0
5
48
1.04
0.09
1.6
1.5
—
—
—
0
0
5
48
1.04
0.09
1.6
1.5
—
—
—
0
0
7
80
0.86
0.07
1.0
1.7
—
—
—
0
0
7
84
0.82
0.07
1.6
1.5
—
—
—
0
0
9
103
0.86
0.06
1.2
1.9
—
—
—
0
0
17
177
0.95
0.01
15.4
3.6
0.00
0.02
estimate
—
10
66
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
13.43
—
0
7
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
7
74
0.94
-0.00
1.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_NONAIHA_OTHER and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_NONAIHA_OTHER.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_NONAIHA_OTHER – Haemolytic-uraemic syndrome
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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