Other nonautoimmune haemolytic anaemias

D3_NOCT_HAEMOGLOBINURIA

hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D59.4 Hospital discharge: ICD-9 — 2831A\|2831B\|2831X Cause of death: ICD-10 — D59.4 Cause of death: ICD-9 — 2831A\|2831B\|2831X 2 out of 7 registries used, show all original rules.	57
4. Check minimum number of events None	57
5. Include endpoints None	57
6. Filter based on genotype QC (FinnGen only)	57

Control definitions (FinnGen only)

Control exclude: D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D59
Name in latin: Aliae anaemiae non autoimmunes haemolyticae

NAME	D3_NOCT_HAEMOGLOBINURIA
CONTROL_EXCLUDE	D3_HAEMOLYTICANAEMIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D594
HD_ICD_9	2831A\|2831B\|2831X
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D594
COD_ICD_9	2831A\|2831B\|2831X
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other nonautoimmune haemolytic anaemias based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	438	222	207
Only index persons	286	140	146
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	65.19	68.72	61.30
Only index persons	61.49	62.70	60.34

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	57	29	28
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	65.30	68.77	61.71

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
54: Matched controls
538

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D59.4

ICD-10 Finland

Other nonautoimmune haemolytic anaemias

+∞

69.9

D59.9

ICD-10 Finland

Acquired haemolytic anaemia, unspecified

+∞

15.3

D64.9

ICD-10 Finland

Anaemia, unspecified

13.7

14.7

C03CA01

ATC

furosemide; systemic

9.4

12.9

117

XW000

NOMESCO Finland

Bone marrow biopsy

26.7

12.6

Z95.2

ICD-10 Finland

Presence of prosthetic heart valve

33.7

11.9

FKB10

NOMESCO Finland

Annuloplasty of mitral valve for insufficiency using ring

120.2

9.8

B01AA03

ATC

warfarin; systemic

6.6

9.1

I34.09

ICD-10 Finland

Mitral (valve) insufficiency

18.5

8.7

D59.1

ICD-10 Finland

Other autoimmune haemolytic anaemias

+∞

8.5

I35.0

ICD-10 Finland

Aortic (valve) stenosis

10.9

8.3

TPH07

NOMESCO Finland

Cathetrisation of artery

9.8

7.9

B01AB05

ATC

enoxaparin; parenteral

5.3

7.9

123

WW500

NOMESCO Finland

Blood transfusion

12.7

7.5

GD1AA

NOMESCO Finland

Thorax X-ray examination

5.2

7.4

169

D50.0

ICD-10 Finland

Iron deficiency anaemia secondary to blood loss (chronic)

35.2

7.4

I34.1

ICD-10 Finland

Mitral (valve) prolapse

16.8

7.3

TFC00

NOMESCO Finland

Catheterisation of right atrium or ventricle

46.0

7.0

I34.00

ICD-10 Finland

Mitral (valve) incompetence NOS or of specified cause, except rheumatic

17.1

6.7

TNE25

NOMESCO Finland

Drill biopsy of bone marrow, pelvis

78.8

6.6

I48

ICD-10 Finland

Atrial fibrillation and flutter

4.4

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

65.05

51.22

2.4

1.4

—

(3023520) Reticulocytes [#/volume] in Blood

21.07

31.76

9.9

2.4

116.41

72.63

e9/l

3.05

(3022948) Iron [Moles/volume] in Serum or Plasma

11.71

19.68

5.9

2.0

12.84

13.16

umol/l

0.08

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

11.18

19.51

5.7

2.1

20.53

22.68

0.44

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

+∞

11.86

2.3

0.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

+∞

11.86

2.3

0.0

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

7.09

11.54

5.6

2.6

12.25

8.00

umol/l

0.77

(3037756) Immunofixation for Serum or Plasma

11.73

11.21

2.7

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

6.97

10.53

7.0

1.2

—

(40760888) Immunoglobulin light chains.free panel - Serum

13.39

10.48

10.2

1.4

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

5.67

9.72

4.9

1.8

30.72

29.09

0.62

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

10.59

9.71

2.0

1.4

0.19

0.25

g/l

1.69

(3001122) Ferritin [Mass/volume] in Serum or Plasma

193

6.61

9.50

8.3

2.4

196.43

139.63

ug/l

1.10

172

(42870588) Differential panel, method unspecified - Blood

155

5.80

9.44

13.3

5.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

5.75

8.36

1.6

1.5

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

9.50

8.29

6.8

1.6

96.18

85.07

0.81

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

5.46

8.14

1.7

1.6

—

(3045142) Bone marrow Pathology biopsy report

18.52

8.13

1.2

1.3

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

8.85

7.84

2.1

1.3

1.03

1.20

g/l

0.86

(3022907) Direct antiglobulin test.polyspecific reagent [Presence] on Red Blood Cells

+∞

7.44

1.4

0.0

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

8.28

7.43

1.5

1.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

16.62

7.23

1.8

—

(3023368) Bacteria identified in Blood by Culture

143

4.41

7.11

6.1

4.0

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

226

5.15

6.98

12.9

4.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

8.45

6.93

1.3

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

119

4.21

6.72

10.0

2.5

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

6.18

6.59

10.9

1.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

255

5.17

6.34

19.3

7.1

1.18

1.22

mmol/l

1.87

214

(3044640) Blood type and Crossmatch panel - Blood

161

4.04

6.24

10.7

2.4

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

270

5.22

6.05

20.7

7.0

20.30

12.13

umol/l

2.16

255

(3021879) Hepatitis B virus core Ab [Presence] in Serum

5.30

5.95

1.4

—

(3012544) pH of Venous blood

4.33

5.39

8.0

4.3

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

4.02

5.27

1.7

1.9

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

211

3.69

5.12

4.1

2.0

90.89

89.88

pmol/l

0.06

103

(3032080) INR in Blood by Coagulation assay

215

3.58

4.89

70.6

7.6

1.96

1.26

inr

2.16

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

15.66

4.70

1.0

1.2

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

13.04

4.40

3.3

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.28

4.16

1.7

1.9

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

179

3.00

3.99

8.2

3.5

3176.39

1234.21

ng/l

0.72

155

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

3.63

3.92

2.1

2.0

9.46

7.17

ug/l

0.33

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

4.64

3.88

4.6

2.4

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

13.17

3.85

1.2

1.6

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

13.17

3.85

2.5

2.4

—

(3026493) Urate [Moles/volume] in Serum or Plasma

142

2.91

3.78

8.9

2.9

447.29

5092.78

umol/l

0.76

115

(3000991) Gas panel - Venous blood

3.62

3.72

22.4

9.9

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

10.97

3.58

1.3

1.8

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

4.28

3.53

13.4

8.2

—

(3018418) pH of Serum or Plasma

163

2.77

3.49

13.6

4.6

7.38

7.40

—

(3003694) ABO and Rh group [Type] in Blood

127

2.73

3.27

1.8

1.4

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

5.63

3.18

3.6

2.7

23.55

25.75

mmol/l

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

161

2.63

3.16

5.7

2.4

61.10

55.39

u/l

0.52

147

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.44

3.07

1.4

1.6

—

(3022313) Gas panel - Capillary blood

5.29

3.04

3.6

2.5

—

(40758558) Short blood count panel - Blood

124

2.62

2.99

17.5

6.8

—

(3019060) Gas panel - Arterial blood

3.55

2.99

5.9

4.5

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

199

2.56

2.99

6.4

3.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

339

3.20

2.95

8.2

4.4

—

(3019230) Fractional oxyhemoglobin in Venous blood

7.29

2.94

6.8

2.6

55.58

63.54

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.70

2.93

1.4

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

4.98

2.91

1.3

1.6

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

7.68

2.60

1.4

—

(3015736) pH of Urine

184

2.33

2.49

4.9

4.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

4.54

2.44

1.6

2.3

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

6.71

2.42

7.2

1.9

32.40

32.50

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

6.71

2.42

1.6

1.5

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

388

2.87

2.40

19.8

8.0

80.02

80.48

u/l

0.04

366

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

5.02

2.33

1.0

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

154

2.27

2.30

5.3

2.7

53.31

33.99

u/l

0.71

144

(21494890) Protein electrophoresis panel - 24 hour Urine

5.96

2.26

3.6

1.1

—

(40761535) Cells panel - Urine sediment

2.93

2.25

1.5

3.5

—

(3004119) Hemoglobin [Mass/volume] in Venous blood

3.25

2.18

4.9

2.8

106.00

123.84

g/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

2.37

2.15

5.6

2.8

1.72

3.47

e6/l

0.55

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

3.84

2.13

1.6

2.6

—

(3034770) Mitochondria Ab [Titer] in Serum

5.36

2.11

1.6

1.0

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.14

2.11

17.9

7.2

25.40

mmol/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

240

2.19

2.11

8.6

5.7

0.00

estimate

—

(3031040) Bacteria [#/volume] in Urine by Automated count

343

2.48

2.08

7.4

4.6

—

35.40

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

118

2.23

2.07

4.7

3.8

—

(3049717) Cytology report of Urine Cyto stain

3.65

2.04

3.3

2.9

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

3.04

2.04

1.7

—

(4035726)

2.66

1.91

1.7

1.4

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

175

2.03

1.81

3.3

2.1

184.89

128.31

u/l

0.74

163

(3027273) Bicarbonate [Moles/volume] in Venous blood

3.18

1.78

4.6

3.2

21.10

24.02

mmol/l

—

(3035350) Ketones [Presence] in Urine by Test strip

241

2.02

1.76

5.9

4.2

0.00

estimate

—

(1616796) Gas panel - Central venous blood

4.10

1.75

1.6

2.5

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

101

2.14

1.75

5.6

2.5

2.44

0.93

e6/l

0.57

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

3.04

1.71

4.1

3.3

56.14

42.34

—

(3045414) Leukocytes [Presence] in Urine

3.40

1.71

3.0

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

243

1.99

1.70

5.9

4.2

0.00

estimate

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.40

1.69

1.8

1.6

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

3.81

1.65

1.0

1.1

—

(36304419) Bacteria [Presence] in Urine

162

1.97

1.64

7.5

2.8

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.92

1.64

4.0

2.7

1.00

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

2.92

1.64

4.0

2.7

0.87

0.72

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.23

1.63

1.2

1.3

—

(3042936) Bacteria identified in Isolate by Culture

2.16

1.59

1.9

1.6

—

(3022145) Colonoscopy Study observation

2.48

1.57

1.7

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.27

1.51

1.8

1.6

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.67

1.34

1.5

2.3

—

(40768797) Stomach Pathology biopsy report

2.08

1.33

1.4

1.2

—

(3026008) Bacteria identified in Urine by Culture

165

1.79

1.25

4.3

3.2

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.12

1.14

2.8

1.7

375.60

373.91

nmol/l

—

(36660697) Celiac disease serology panel - Serum

2.20

1.07

1.0

1.2

—

(3019225) pH of Specimen

2.04

1.07

6.2

5.0

—

(3025941) Bacteria identified in Stool by Culture

2.07

1.01

1.0

1.3

—

(3002256) Pathology report gross observation

1.92

0.98

1.7

1.2

—

(3000330) Specific gravity of Urine by Test strip

2.36

0.97

7.8

4.7

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.95

0.95

5.6

2.6

37.30

29.22

u/l

—

(40768804) Tissue Pathology biopsy report

197

1.59

0.89

2.2

2.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.81

0.78

3.7

4.0

—

(3013512) EKG study

147

1.56

0.76

7.5

5.0

—

(3002385) Erythrocyte distribution width [Ratio]

387

1.60

0.71

72.9

18.7

15.81

13.81

2.94

379

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

470

1.81

0.70

50.3

15.8

24.84

23.60

mg/l

0.16

368

(40760892) CBC W Ordered Manual Differential panel - Blood

106

1.56

0.66

3.9

5.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

251

1.41

0.57

3.2

2.9

—

(1761868) Lipid panel - Serum or Plasma

163

0.67

0.54

4.9

3.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

186

1.40

0.52

6.5

4.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

131

1.42

0.50

1.9

1.6

1.03

1.34

mmol/l

1.46

106

(3009542) Hematocrit [Volume Fraction] of Blood

410

1.46

0.48

72.1

16.2

35.34

39.79

3.61

274

(3044889) 12 lead EKG panel

340

1.35

0.43

7.9

4.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.39

0.42

1.5

1.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.42

0.0

1.4

—

39.60

—

(3000492) Spirometry study

1.43

0.39

1.4

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

133

1.28

0.28

6.4

4.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.35

0.24

1.0

1.8

—

(3022621) pH of Urine by Test strip

1.31

0.23

3.0

2.4

—

(40761536) Microorganisms panel - Urine sediment

1.21

0.22

4.4

4.3

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.21

0.0

2.3

—

3.16

—

(3042810) Amyloid beta 42 peptide [Mass/volume] in Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

392.40

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(1002224) Polysomnography panel

0.00

0.20

0.0

1.0

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

494

1.31

0.17

61.6

18.8

138.33

139.66

mmol/l

2.58

479

(40761511) CBC panel - Blood by Automated count

483

1.29

0.16

53.6

14.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

464

0.86

0.11

5.2

5.0

6.16

6.06

mmol/l

0.17

419

(3026361) Erythrocytes [#/volume] in Blood

516

0.89

0.09

92.3

23.2

3.54

4.46

e12/l

13.43

494

(3035941) MCH [Entitic mass]

516

0.89

0.09

91.8

23.0

31.44

30.47

1.65

506

(3000963) Hemoglobin [Mass/volume] in Blood

516

0.89

0.09

92.9

23.3

109.53

135.22

g/l

13.99

505

(3010813) Leukocytes [#/volume] in Blood

516

0.89

0.09

92.1

23.2

11.06

6.69

e9/l

0.48

494

(3024731) MCV [Entitic volume]

516

0.89

0.09

91.8

23.1

95.39

91.50

3.14

506

(3007461) Platelets [#/volume] in Blood

514

0.93

0.09

92.4

23.2

224.35

244.03

e9/l

1.07

497

(3023103) Potassium [Moles/volume] in Serum or Plasma

499

1.21

0.08

63.5

18.7

4.05

3.96

mmol/l

1.60

485

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

498

1.23

0.08

25.7

11.5

26.76

24.87

u/l

0.22

479

(3020564) Creatinine [Moles/volume] in Serum or Plasma

497

1.25

0.08

59.8

19.5

105.33

80.19

umol/l

3.79

497

(3003338) MCHC [Mass/volume]

381

1.07

0.03

84.8

20.5

329.10

332.37

g/l

1.08

381

(4027681)

0.00

0.0

1.3

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.8

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

0.0

2.7

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.3

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.3

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.6

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.9

—

(3020491) Glucose [Moles/volume] in Blood

0.00

0.0

1.4

—

7.26

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.0

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.0

1.4

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.4

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.0

—

(3000494) Fungus identified in Specimen by Culture

0.87

0.00

2.0

1.5

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

0.0

1.3

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.0

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

0.0

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.00

0.00

12.0

8.1

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.0

6.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.00

0.00

1.6

1.2

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

4.4

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

0.0

2.4

—

44.40

—

Mortality – FinRegistry

↥

Association

Association between endpoint D3_NOCT_HAEMOGLOBINURIA and mortality.

Females

Parameter	HR [95% CI]	p-value
D3_NOCT_HAEMOGLOBINURIA	2.556 [1.24, 5.26]	0.011
Birth year	0.994 [0.99, 1.0]	0.161

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 139 females with D3_NOCT_HAEMOGLOBINURIA died.

Males

Parameter	HR [95% CI]	p-value
D3_NOCT_HAEMOGLOBINURIA	3.81 [2.25, 6.45]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.004

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 138 males with D3_NOCT_HAEMOGLOBINURIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_NOCT_HAEMOGLOBINURIA.

N-year risk	Females	Males
1	0.305%	0.681%
5	1.497%	4.41%
10	3.57%	10.283%
15	6.782%	17.758%
20	11.725%	28.367%

Relationships between endpoints

↥

Index endpoint: D3_NOCT_HAEMOGLOBINURIA – Other nonautoimmune haemolytic anaemias

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other nonautoimmune haemolytic anaemias

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints