≡ Risteys
R13

Documentation Changelog GitHub Contact & Feedback

Other nonautoimmune haemolytic anaemias

DOID EFO Endpoint Browser PheWeb

D3_NOCT_HAEMOGLOBINURIA

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D59.4
  • Hospital discharge: ICD-9 — 2831A|2831B|2831X
  • Cause of death: ICD-10 — D59.4
  • Cause of death: ICD-9 — 2831A|2831B|2831X

2 out of 7 registries used, show all original rules.

69

4. Check minimum number of events

None

69

5. Include endpoints

None

69

6. Filter based on genotype QC (FinnGen only)

67

Control definitions (FinnGen only)

Control exclude
D3_HAEMOLYTICANAEMIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D59
Name in latin
Aliae anaemiae non autoimmunes haemolyticae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 438 222 207
Only index persons 286 140 146
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 65.19 68.72 61.30
Only index persons 61.49 62.70 60.34

-FinnGen-

Key figures

All Female Male
Number of individuals 67 34 33
Unadjusted period prevalence (%) 0.01 0.01 0.02
Median age at first event (years) 67.19 68.72 65.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
69
Matched controls
690
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D59.4
ICD-10 Finland
Other nonautoimmune haemolytic anaemias
+∞
91.4
66
*
D64.9
ICD-10 Finland
Anaemia, unspecified
18.0
33.6
38
44
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
52.6
19.0
22
6
D59.9
ICD-10 Finland
Acquired haemolytic anaemia, unspecified
+∞
17.4
16
*
C03CA01
ATC
furosemide; systemic
8.5
16.1
51
173
B01AA03
ATC
warfarin; systemic
7.2
15.3
36
91
XW000
NOMESCO Finland
Bone marrow biopsy
24.9
14.4
20
11
I35.0
ICD-10 Finland
Aortic (valve) stenosis
9.9
10.6
22
31
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
22.4
9.3
13
7
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
42.9
9.3
11
*
WW500
NOMESCO Finland
Blood transfusion
13.3
8.8
15
14
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
10.3
8.7
17
21
D59.1
ICD-10 Finland
Other autoimmune haemolytic anaemias
+∞
8.5
8
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
8.3
8.5
19
30
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
4.3
8.3
36
140
TPH07
NOMESCO Finland
Cathetrisation of artery
5.2
8.0
20
50
I34.1
ICD-10 Finland
Mitral (valve) prolapse
12.2
8.0
14
14
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
51.0
7.9
9
*
D64.8
ICD-10 Finland
Other specified anaemias
51.0
7.9
9
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.4
7.5
25
79
D59.8
ICD-10 Finland
Other acquired haemolytic anaemias
+∞
7.4
7
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
12.0
7.4
13
13
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.1
7.3
29
104
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.9
7.0
32
126
B01AB05
ATC
enoxaparin; parenteral
3.7
6.7
38
172
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
6.5
49
265
R31
ICD-10 Finland
Unspecified haematuria
4.8
6.4
17
44
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
11.6
6.3
11
11
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
4.5
6.3
18
50
I50.9
ICD-10 Finland
Heart failure, unspecified
3.9
6.1
23
78
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
7.3
6.1
14
23

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
27
38.20
53.27
7.1
1.6
0.73
1.79
g/l
4.85
23
22
45
56
21.23
38.65
8.9
2.9
117.05
70.58
e9/l
4.10
37
44
44
88
12.04
25.03
4.9
2.5
22.04
22.77
%
0.10
37
78
48
107
12.45
24.90
5.2
2.3
13.51
13.26
umol/l
0.06
48
98
36
107
5.94
12.43
4.6
1.9
30.49
29.27
s
0.54
36
102
25
54
6.69
12.10
6.4
1.3
—
—
—
0
0
26
62
6.12
11.29
5.3
2.7
11.89
7.56
umol/l
0.91
26
52
21
43
6.58
10.60
4.1
2.2
248.19
238.14
ng/l
0.04
21
38
55
269
6.15
9.79
11.4
6.6
—
—
—
0
0
13
8
19.59
8.96
1.3
1.3
—
—
—
0
0
13
9
17.41
8.60
1.8
1.7
—
—
—
0
0
15
16
11.62
8.29
2.5
1.2
—
—
—
0
0
13
13
12.00
7.41
9.5
1.5
—
—
—
0
0
50
260
4.35
7.36
3.6
2.0
91.88
91.09
pmol/l
0.05
34
132
23
69
4.50
7.34
1.5
1.4
384.00
665.88
titre
—
5
17
21
62
4.43
6.80
1.6
1.4
—
—
—
0
0
23
74
4.16
6.64
1.7
1.5
—
—
—
0
0
56
332
4.65
6.49
18.0
6.7
19.66
11.90
umol/l
2.52
56
312
12
15
9.42
6.14
2.0
1.4
0.19
0.24
g/l
1.65
12
15
40
195
3.50
6.14
9.6
2.5
—
—
—
0
0
53
309
4.08
6.13
17.6
7.2
1.19
1.22
mmol/l
1.90
48
260
36
175
3.21
5.37
5.9
4.2
—
—
—
0
0
12
19
7.40
5.36
1.4
1.2
—
—
—
0
0
28
118
3.31
5.29
2.8
1.4
1.96
2.68
g/l
1.74
23
75
11
16
7.95
5.19
2.1
1.4
1.03
1.20
g/l
0.94
11
16
16
48
4.04
4.96
2.0
4.9
0.38
0.44
%
—
8
16
15
44
4.08
4.78
1.3
1.3
—
—
—
0
0
18
62
3.57
4.58
7.6
4.6
—
—
—
0
0
31
152
2.89
4.37
1.6
1.4
—
—
—
0
0
49
308
3.04
4.31
92.2
12.5
2.02
1.28
inr
2.75
17
89
13
32
4.76
4.17
11.8
7.5
—
—
—
0
0
12
32
4.32
3.60
4.2
2.3
—
—
—
0
0
13
42
3.58
3.59
5.8
4.2
—
—
—
0
0
20
85
2.91
3.57
1.6
1.8
—
—
—
0
0
15
55
3.21
3.42
2.0
4.8
0.71
0.71
%
—
7
21
15
56
3.14
3.31
21.5
10.0
—
—
—
0
0
34
197
2.43
3.22
12.5
4.7
7.39
7.40
ph
—
6
36
34
197
2.43
3.22
5.1
2.4
61.76
78.51
u/l
0.32
34
182
56
412
2.91
3.11
7.9
4.5
—
—
—
0
0
11
32
3.89
3.06
9.5
5.7
24.56
24.30
mmol/l
0.13
11
32
14
53
3.06
3.01
2.1
4.9
0.00
0.16
%
—
6
19
9
22
4.54
3.00
3.3
3.0
23.82
25.25
mmol/l
—
9
22
6
9
7.17
2.93
3.2
1.1
—
—
—
0
0
60
475
3.01
2.89
17.0
8.1
78.23
79.74
u/l
0.15
60
448
19
89
2.57
2.77
17.4
6.9
104.58
103.06
mmol/l
0.41
19
89
6
10
6.45
2.76
1.3
1.5
—
—
—
0
0
9
25
3.98
2.68
3.3
2.6
—
—
—
0
0
13
51
2.91
2.62
2.0
4.9
0.00
0.53
%
—
5
17
6
11
5.85
2.60
7.0
2.2
32.33
32.00
pg
—
6
11
21
111
2.28
2.33
5.0
3.1
1.72
3.64
e6/l
0.67
13
65
6
13
4.94
2.32
6.8
2.5
55.58
60.90
%
—
6
13
30
187
2.07
2.20
6.4
2.9
—
—
—
0
0
25
146
2.12
2.17
16.9
6.8
—
—
—
0
0
32
208
2.00
2.07
6.3
3.3
126.66
43.35
e6/l
0.50
26
163
10
39
2.82
2.04
1.0
1.2
—
—
—
0
0
10
39
2.82
2.04
16.9
7.3
25.16
25.28
mmol/l
—
10
39
5
11
4.80
1.97
1.6
1.4
—
—
—
0
0
35
239
1.94
1.93
6.9
3.8
60.36
52.30
e6/l
0.09
28
173
8
28
3.09
1.93
3.0
3.1
—
—
—
0
0
30
195
1.95
1.91
6.5
3.1
0.70
0.43
e6/l
0.29
24
149
52
410
2.09
1.85
7.0
4.6
—
35.40
—
0
10
5
12
4.40
1.85
2.4
3.4
—
—
—
0
0
6
18
3.55
1.79
1.5
1.7
6.78
8.08
kpa
—
6
18
5
13
4.06
1.74
1.0
1.1
—
—
—
0
0
5
13
4.06
1.74
1.6
1.1
—
—
—
0
0
5
13
4.06
1.74
11.8
2.0
—
—
—
0
0
17
93
2.10
1.70
1.3
1.2
—
—
—
0
0
40
294
1.86
1.70
8.1
5.9
0.00
0.00
estimate
—
6
63
12
57
2.34
1.66
1.7
1.4
—
—
—
0
0
11
51
2.38
1.60
1.5
3.6
—
—
—
0
0
23
144
1.90
1.59
4.3
3.7
—
—
—
0
0
5
15
3.51
1.55
1.0
1.2
—
—
—
0
0
9
40
2.43
1.47
4.9
3.0
106.00
124.90
g/l
—
9
40
5
16
3.28
1.46
1.6
2.4
—
—
—
0
0
29
201
1.76
1.43
3.2
2.1
179.38
131.35
u/l
0.65
29
187
39
296
1.73
1.39
5.6
4.2
0.00
0.00
estimate
—
6
66
12
63
2.10
1.32
1.7
1.3
—
—
—
0
0
39
299
1.70
1.32
5.6
4.3
0.00
0.00
estimate
—
6
59
6
26
2.43
1.21
3.0
1.9
—
—
—
0
0
26
182
1.69
1.21
4.5
3.2
2268.21
392.74
mg/l
0.41
21
118
11
58
2.07
1.20
2.6
1.8
358.36
371.46
nmol/l
0.10
11
48
7
30
2.48
1.16
4.6
3.6
21.10
24.23
mmol/l
—
7
30
11
59
2.03
1.15
5.7
4.9
—
—
—
0
0
26
185
1.65
1.13
7.3
4.8
—
—
—
0
0
5
21
2.48
1.11
1.0
1.4
—
—
—
0
0
13
77
1.85
1.04
1.7
1.3
—
—
—
0
0
7
35
2.11
1.03
4.0
2.7
0.87
0.68
%
—
7
35
7
35
2.11
1.03
4.0
2.7
1.00
1.06
%
—
7
35
26
193
1.56
0.92
4.8
3.7
45.63
6.86
mg/mmol
0.76
20
122
14
207
0.59
0.92
4.4
3.2
—
—
—
0
0
15
97
1.70
0.91
1.9
1.6
—
—
—
0
0
48
412
1.54
0.85
3.6
4.2
15.11
15.09
pmol/l
0.02
43
369
26
198
1.50
0.81
4.5
3.1
—
—
—
0
0
7
42
1.74
0.71
1.0
1.3
—
—
—
0
0
30
244
1.41
0.64
2.2
2.2
—
—
—
0
0
8
51
1.64
0.63
1.4
1.4
—
—
—
0
0
14
98
1.54
0.62
1.6
1.3
39.28
44.08
iu/ml
—
5
37
6
39
1.59
0.54
7.8
4.9
—
—
—
0
0
20
159
1.36
0.47
1.8
1.5
0.97
1.32
mmol/l
2.25
15
129
63
599
1.59
0.46
53.6
18.6
138.35
139.65
mmol/l
3.10
63
583
5
33
1.55
0.42
1.8
3.9
0.11
0.07
e6/l
—
5
33
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
0
18
0.00
0.40
0.0
5.0
—
30.69
—
0
11
63
604
1.49
0.35
55.0
18.4
4.03
3.97
mmol/l
0.92
63
589
63
603
1.51
0.35
52.5
19.3
102.02
80.50
umol/l
3.83
63
603
53
495
1.30
0.35
63.3
18.3
16.34
15.04
%
1.07
53
488
9
72
1.29
0.27
1.4
1.6
—
—
—
0
0
45
421
1.20
0.24
7.9
4.3
—
—
—
0
0
19
164
1.22
0.23
6.0
4.1
—
—
—
0
0
5
39
1.30
0.23
1.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
297.00
—
0
5
0
12
0.00
0.21
0.0
2.1
—
3.07
—
0
6
0
12
0.00
0.21
0.0
4.8
—
—
—
0
0
6
79
0.74
0.16
2.0
1.5
—
—
—
0
0
48
459
1.15
0.15
72.6
20.4
329.75
332.26
g/l
0.84
48
459
18
165
1.12
0.10
5.6
4.2
0.00
0.00
estimate
—
5
62
5
48
1.04
0.09
1.0
1.8
—
—
—
0
0
6
53
1.14
0.09
4.3
3.9
—
—
—
0
0
60
586
1.18
0.07
47.7
14.9
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
264.50
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
7.26
—
0
5
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
63
624
1.11
-0.00
80.3
23.4
110.60
135.33
g/l
16.97
63
613
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
63
624
1.11
-0.00
79.4
23.2
94.79
91.54
fl
3.15
63
614
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
3.0
2.7
—
—
—
0
0
63
624
1.11
-0.00
79.4
23.2
31.37
30.48
pg
1.84
63
614
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
2.32
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
3.70
—
0
6

Mortality – FinRegistry

↥

Association

Association between endpoint D3_NOCT_HAEMOGLOBINURIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_NOCT_HAEMOGLOBINURIA 2.556 [1.24, 5.26] 0.011
Birth year 0.994 [0.99, 1.0] 0.161

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 139 females with D3_NOCT_HAEMOGLOBINURIA died.

Males

Parameter HR [95% CI] p-value
D3_NOCT_HAEMOGLOBINURIA 3.81 [2.25, 6.45] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 138 males with D3_NOCT_HAEMOGLOBINURIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_NOCT_HAEMOGLOBINURIA.

N-year risk Females Males
1 0.305% 0.681%
5 1.497% 4.41%
10 3.57% 10.283%
15 6.782% 17.758%
20 11.725% 28.367%

Relationships between endpoints

↥

Index endpoint: D3_NOCT_HAEMOGLOBINURIA – Other nonautoimmune haemolytic anaemias

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data