This is a non-core endpoint: only basic statistics are computed.

Necrotizing enterocolitis of fetus and newborn

Endpoint Browser

P16_NECROTIZ_ENTEROCOLITIS_FETUS_NEWBO

No definition available.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — P77 Cause of death: ICD-10 — P77 2 out of 7 registries used, show all original rules.	10
4. Check minimum number of events None	10
5. Include endpoints None	10
6. Filter based on genotype QC (FinnGen only)	7

Control definitions (FinnGen only)

Control exclude: P16_DIGES_SYSTEM_DISORD_FETUS_NEWBO

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: P7[5-8]
Name in latin: Enterocolitis necroticans neonati

NAME	P16_NECROTIZ_ENTEROCOLITIS_FETUS_NEWBO
CONTROL_EXCLUDE	P16_DIGES_SYSTEM_DISORD_FETUS_NEWBO
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	P77
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	P77
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Necrotizing enterocolitis of fetus and newborn based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	508	203	305
Only index persons	185	77	108
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	0.00	0.00
Only index persons	0.00	0.00	0.00

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	7	-	-
Unadjusted period prevalence (%)	0.00	-	-
Median age at first event (years)	0.00	-	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

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N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

7.84

2.25

2.4

13.9

2.16

2.96

g/l

—

(3036489) Thrombin time

7.12

2.11

2.2

12.5

23.60

23.67

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

7.12

2.11

2.2

11.9

133.00

167.75

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

5.54

1.77

6.8

11.1

81.80

80.47

—

(3020779) Urea [Moles/volume] in Serum or Plasma

4.19

1.41

12.2

20.5

5.68

4.26

mmol/l

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

3.13

0.90

12.8

8.1

64.20

37.58

u/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

3.13

0.90

4.8

3.8

—

(3000991) Gas panel - Venous blood

2.96

0.88

12.4

9.3

—

(3044889) 12 lead EKG panel

2.82

0.85

3.6

1.7

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

2.55

0.79

6.8

16.3

23.40

22.79

mmol/l

—

(40761511) CBC panel - Blood by Automated count

+∞

0.69

39.5

9.1

—

(3012544) pH of Venous blood

2.31

0.55

9.4

20.3

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

2.31

0.55

9.4

19.8

6.04

5.51

kpa

—

(3002032) Base excess in Venous blood by calculation

2.31

0.55

9.4

19.8

0.14

0.24

mmol/l

—

(3024354) Oxygen [Partial pressure] in Venous blood

2.31

0.55

9.4

19.8

4.83

5.94

kpa

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.45

0.0

1.1

—

(3003694) ABO and Rh group [Type] in Blood

1.69

0.30

3.2

2.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.23

0.0

1.3

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

0.00

0.23

0.0

10.4

—

813.55

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.22

0.0

2.5

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

4.8

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

4.8

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

0.0

3.6

—

1486.20

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

2.0

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.0

3.6

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.0

1.2

—

(3022621) pH of Urine by Test strip

0.00

0.0

1.8

—

(3032352) Blasts [#/volume] in Cerebral spinal fluid

0.00

0.0

7.4

—

(3001405) CD3+CD8+ (T8 suppressor) cells [#/volume] in Blood

0.00

0.0

5.2

—

722.00

—

(3007449) CD3+CD8+ (T8 suppressor) cells/100 cells in Blood

0.00

0.0

5.2

—

24.00

—

(3025271) CD3-CD16+CD56+ (Natural killer) cells [#/volume] in Blood

0.00

0.0

5.2

—

0.25

—

(3052851) Hemolysis interference index of Serum or Plasma

0.00

0.0

1.6

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

-0.00

0.0

1.4

—

(3017732) Neutrophils [#/volume] in Blood

0.00

-0.00

0.0

2.9

—

3.70

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

-0.00

0.0

2.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

-0.00

0.0

3.8

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

5.4

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

-0.00

0.0

2.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

-0.00

0.0

2.8

—

(3000060) B lymphocytes [#/volume] in Blood

0.00

-0.00

0.0

4.7

—

698.33

—

(3007461) Platelets [#/volume] in Blood

+∞

-0.00

52.7

24.0

308.10

283.61

e9/l

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.5

—

9.87

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.4

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

-0.00

0.0

1.4

—

(3006245) CD3-CD19+ cells/100 cells in Blood

0.00

-0.00

0.0

5.3

—

15.83

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

15.23

—

(4200892) Spirometry reversibility

0.00

-0.00

0.0

1.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

-0.00

0.0

3.1

—

(3026361) Erythrocytes [#/volume] in Blood

+∞

-0.00

52.7

23.8

4.54

4.31

e12/l

—

(3010813) Leukocytes [#/volume] in Blood

+∞

-0.00

52.5

23.8

7.64

8.01

e9/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

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Association

Association between endpoint P16_NECROTIZ_ENTEROCOLITIS_FETUS_NEWBO and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have P16_NECROTIZ_ENTEROCOLITIS_FETUS_NEWBO.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: P16_NECROTIZ_ENTEROCOLITIS_FETUS_NEWBO – Necrotizing enterocolitis of fetus and newborn

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Necrotizing enterocolitis of fetus and newborn

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints