This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

M13_SYSTSLCE

Systemic sclerosis induced by drugs and chemicals

Endpoint Browser

SYSTEMIC_SCLEROSIS_INDUCED_DRUGS_CHEMIC

No definition available.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M34.2# 1 out of 7 registries used, show all original rules.	9
4. Check minimum number of events None	9
5. Include endpoints None	9
6. Filter based on genotype QC (FinnGen only)	9

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	SYSTEMIC_SCLEROSIS_INDUCED_DRUGS_CHEMIC
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M342
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Systemic sclerosis induced by drugs and chemicals based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	46	28	17
Only index persons	43	26	17
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	57.05	55.83	58.34
Only index persons	56.57	55.41	58.34

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	9	6	-
Unadjusted period prevalence (%)	0.00	0.00	-
Median age at first event (years)	50.59	48.97	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

+∞

0.70

3.0

4.3

4.2

4.6

mmol/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.23

0.0

1.2

—

(40761511) CBC panel - Blood by Automated count

+∞

0.23

31.0

11.9

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.23

0.0

1.2

—

(40761535) Cells panel - Urine sediment

0.00

0.23

0.0

2.5

—

(3027945) Reticulocytes/100 erythrocytes in Blood

0.00

0.23

0.0

6.5

—

2.1

—

(3005229) Alpha 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

7.9

—

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3020630) Protein [Mass/volume] in Serum or Plasma

0.00

0.0

1.6

—

67.4

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.8

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.0

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.2

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

3.4

—

(3023465) Gamma globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

9.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.0

9.2

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

40.5

—

(3043747) Beta 2 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

3.3

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3015322) Alpha 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

3.2

—

(3029713) Protein.monoclonal band 1 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

2.0

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.0

4.6

—

15.4

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.0

1.8

—

25.3

—

(3035797) Protein.monoclonal band 2 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

1.0

—

0.0

—

(3000963) Hemoglobin [Mass/volume] in Blood

+∞

0.00

49.2

22.4

130.9

134.5

g/l

—

(3024731) MCV [Entitic volume]

+∞

0.00

45.6

22.3

94.2

90.8

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

0.00

0.0

2.0

—

5.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

0.00

0.0

1.9

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.0

1.2

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.4

—

(3035941) MCH [Entitic mass]

+∞

0.00

45.3

22.3

30.9

30.2

—

(3022621) pH of Urine by Test strip

0.00

0.0

1.8

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint SYSTEMIC_SCLEROSIS_INDUCED_DRUGS_CHEMIC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have SYSTEMIC_SCLEROSIS_INDUCED_DRUGS_CHEMIC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: SYSTEMIC_SCLEROSIS_INDUCED_DRUGS_CHEMIC – Systemic sclerosis induced by drugs and chemicals

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Systemic sclerosis induced by drugs and chemicals

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints