systemic scleroderma: A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
912 |
4. Check minimum number of eventsNone |
912 |
5. Include endpointsNone |
912 |
6. Filter based on genotype QC (FinnGen only) |
883 |
Control definitions (FinnGen only)
- Control exclude
- M13_SYSTCONNECT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M30-M36
- Name in latin
- Sclerosis systemica
Similar endpoints
↥List of similar endpoints to
Systemic sclerosis
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis (FG)
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4561 | 3620 | 887 |
| Only index persons | 3885 | 3150 | 735 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.02 |
| Only index persons | 0.10 | 0.12 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 56.25 | 56.54 | 55.13 |
| Only index persons | 55.13 | 55.34 | 54.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 883 | 727 | 156 |
| Unadjusted period prevalence (%) | 0.22 | 0.26 | 0.07 |
| Median age at first event (years) | 55.22 | 54.99 | 56.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 912
- Matched controls
- 9120
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
307.7
571
*
I73.0
ICD-10 Finland
Raynaud syndrome
68.1
307.7
256
52
P01BA02
ATC
hydroxychloroquine; oral
26.4
307.7
503
406
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
27.8
307.7
582
544
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
6605.8
307.7
401
*
L04AX03
ATC
methotrexate; systemic
13.8
307.7
401
492
C08CA05
ATC
nifedipine; systemic
30.1
307.7
400
231
XX9XE
NOMESCO Finland
Other ultrasound examination
117.4
307.7
187
20
L04AA06
ATC
mycophenolic acid; systemic
60.3
296.9
168
34
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
94.8
221.7
116
14
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.5
217.3
264
312
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
2281.5
188.3
176
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
184.8
171
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.3
170.3
186
186
L04AX01
ATC
azathioprine; systemic
14.5
168.2
163
135
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
7.8
158.7
267
458
G04BE03
ATC
sildenafil; oral
50.5
149.5
87
19
L88
ICPC
Rheumatoid/seropositive arthritis
10.6
128.9
153
170
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
9.9
119.7
149
176
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
48.9
116.2
68
15
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
116.2
109
*
XPX04
NOMESCO Finland
Angioscopy
326.4
114.9
114
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.3
103.9
482
1891
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
7.5
99.0
157
246
XG410
NOMESCO Finland
Flow-volume spirometry
9.4
98.2
125
151
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
12.5
96.5
99
88
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.0
88.5
372
1332
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.7
86.6
99
103
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.9
82.7
168
336
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.8
82.1
597
3030
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
850.1
80.7
78
*
C08CA02
ATC
felodipine; oral
5.1
72.9
178
417
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
13.8
71.5
68
53
M35.1
ICD-10 Finland
Other overlap syndromes
+∞
70.8
67
*
R4120
NOMESCO Finland
Occupational therapy
5.5
69.7
149
310
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
357.4
67.5
67
*
H02AB06
ATC
prednisolone; systemic
3.2
62.7
585
3256
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
12.2
62.6
64
56
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
16.5
61.9
53
34
NH3EA
NOMESCO Finland
Feet X-ray examination with load
9.7
61.5
74
82
K74.3
ICD-10 Finland
Primary biliary cirrhosis
25.9
59.8
42
17
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
9.2
57.5
72
84
L01BA01
ATC
methotrexate; systemic
6.9
57.3
93
147
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
56.5
256
926
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.0
54.9
183
539
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
9.5
54.3
66
74
L04AD01
ATC
ciclosporin; systemic
11.6
53.3
56
51
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
52.9
469
2464
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.1
52.3
167
476
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
4.4
51.3
142
363
GD1AD
NOMESCO Finland
Thorax CT examination
5.2
50.7
112
238
M34
ICD-10 Finland
Systemic sclerosis
+∞
47.3
45
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.8
44.5
155
467
SBA10
NOMESCO Finland
Measurement of salivary flow rate
13.8
43.6
41
31
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
8.1
43.3
60
79
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
157.6
43.2
45
*
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
17.3
42.0
35
21
TGC00
NOMESCO Finland
Bronchial lavation
7.7
41.5
60
83
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
40.9
39
*
L04AA01
ATC
[U] ciclosporin
11.9
40.7
42
37
WZA10
NOMESCO Finland
Extensive medical or dental certificate
10.2
39.5
45
46
C02KX01
ATC
bosentan; oral
+∞
37.8
36
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.6
36.7
138
435
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.5
36.7
95
229
A05AA02
ATC
ursodeoxycholic acid; oral
8.4
34.9
46
57
Z01.8
ICD-10 Finland
Other specified special examinations
2.5
32.2
282
1400
E0000UV, ,
ATC
2.3
31.6
467
2896
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
7.2
31.2
47
68
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
48.1
30.8
37
8
C08CA01
ATC
amlodipine; oral
2.2
30.6
418
2500
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.3
30.6
53
89
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.7
28.9
98
287
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.6
27.4
95
282
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.1
27.4
495
3259
C02KX04
ATC
macitentan; oral
+∞
27.2
26
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.2
26.8
119
413
J01FF01
ATC
clindamycin; systemic
2.2
26.8
309
1706
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.2
26.6
56
113
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
+∞
26.2
25
*
H02AB07
ATC
prednisone; oral
2.6
25.7
173
751
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
25.6
243
1233
R06.0
ICD-10 Finland
Dyspnoea
2.2
24.9
302
1691
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
256.8
24.8
25
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
24.6
245
1266
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.3
24.2
98
321
R4190
NOMESCO Finland
Nutritional therapy
4.6
23.2
56
127
L99
ICPC
Musculoskeletal disease other
5.9
23.1
42
74
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
3.4
23.0
86
268
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
22.9
160
704
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.9
22.3
116
439
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
64.2
21.9
25
*
RT172, ,
NOMESCO Finland
64.2
21.9
25
*
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
8.2
21.0
28
35
RT160, ,
NOMESCO Finland
61.5
21.0
24
*
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
+∞
20.9
20
*
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.9
20.5
106
399
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
20.4
143
628
A02BC02
ATC
pantoprazole; systemic
2.1
20.3
672
5248
K22.1
ICD-10 Finland
Ulcer of oesophagus
7.5
20.0
29
40
M01CC01
ATC
penicillamine; oral
58.9
20.0
23
*
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.0
19.7
58
153
A02BC01
ATC
omeprazole; systemic
2.0
19.3
286
1699
UJF32
NOMESCO Finland
Coloscopy
2.0
19.0
278
1641
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
16.3
18.9
30
19
M32.8
ICD-10 Finland
Other forms of systemic lupus erythematosus
+∞
18.8
18
*
RT274, ,
NOMESCO Finland
39.3
18.6
23
6
I27.0
ICD-10 Finland
Primary pulmonary hypertension
53.6
18.0
21
*
K22.7
ICD-10 Finland
Barrett oesophagus
7.1
17.9
27
39
NHQ40
NOMESCO Finland
Amputation of toe
7.5
17.4
25
34
M05BA04
ATC
alendronic acid; oral
2.6
17.2
110
461
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.9
17.2
31
54
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
5.0
16.7
36
74
ZX120
NOMESCO Finland
Intravenous
2.5
16.7
112
480
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
16.7
16
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.9
16.7
81
294
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.7
16.5
92
360
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
16.2
403
2790
R50.9
ICD-10 Finland
Fever, unspecified
2.2
16.2
151
748
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
16.0
123
562
C03CA01
ATC
furosemide; systemic
1.9
15.9
264
1612
R15
ICD-10 Finland
Faecal incontinence
3.6
15.9
54
158
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
+∞
15.7
15
*
N02AX02
ATC
tramadol; systemic, rectal
1.8
15.7
407
2847
J01MA12
ATC
levofloxacin; systemic
2.1
15.6
182
983
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.3
15.6
133
635
M05BA07
ATC
risedronic acid; oral
3.6
15.5
51
146
RT271, ,
NOMESCO Finland
38.8
15.4
19
5
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.6
15.2
90
363
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
32.3
14.8
19
6
E000001, ,
ATC
2.0
14.8
206
1183
L03.0
ICD-10 Finland
Cellulitis of finger and toe
2.5
14.7
98
419
K62.3
ICD-10 Finland
Rectal prolapse
5.5
14.5
28
52
L95
ICPC
Osteoporosis
3.1
14.1
61
207
J01DB01
ATC
cefalexin; oral
2.1
14.1
769
6597
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
6.8
14.1
22
33
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
5.5
14.1
27
50
M05BX04
ATC
denosumab; parenteral
2.7
14.0
81
323
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
13.8
113
529
S97
ICPC
Chronic ulcer skin
2.9
13.6
67
245
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
13.6
99
440
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
5.5
13.6
26
48
7100A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
+∞
13.6
13
*
M32.0
ICD-10 Finland
Drug-induced systemic lupus erythematosus
+∞
13.6
13
*
M35.7
ICD-10 Finland
Hypermobility syndrome
26.2
13.4
18
7
Z3226
NOMESCO Finland
Physiotherapist
1.9
13.3
190
1097
R13
ICD-10 Finland
Dysphagia
2.5
13.2
84
351
A02BC05
ATC
esomeprazole; systemic
1.7
13.2
408
2954
RT272, ,
NOMESCO Finland
19.4
12.9
19
10
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.1
12.9
56
191
S01XA18
ATC
ciclosporin; ophthalmic
10.7
12.8
24
23
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.2
12.8
112
539
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
12.7
97
440
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
12.7
201
1198
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
4.2
12.6
33
80
C02DE02, ,
ATC
11.2
12.6
23
21
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
12.5
102
476
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
24.7
12.5
17
7
D06BX01
ATC
metronidazole; topical
2.1
12.4
132
686
S09
ICPC
Infected finger/toe
3.4
12.3
44
133
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.1
12.2
33
82
M79.0
ICD-10 Finland
Rheumatism, unspecified
3.2
12.1
49
160
J02AC01
ATC
fluconazole; systemic
1.6
12.1
426
3167
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
27.1
12.1
16
6
K11.2
ICD-10 Finland
Sialoadenitis
3.3
11.9
44
136
RT231, ,
NOMESCO Finland
47.3
11.9
14
*
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
11.9
272
1805
R4180
NOMESCO Finland
Podiatric therapy
5.9
11.8
21
36
SPAT1263
SPAT
Sampling
1.6
11.8
386
2810
N03AX16
ATC
[U] pregabalin
1.8
11.8
234
1490
J96.1
ICD-10 Finland
Chronic respiratory failure
5.0
11.7
25
51
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
11.7
121
621
NDQ20
NOMESCO Finland
Amputation of finger
23.2
11.6
16
7
R1250
NOMESCO Finland
Evaluation of functional capability
3.9
11.6
34
90
M13.9
ICD-10 Finland
Arthritis, unspecified
2.5
11.5
78
335
73409
ICD-8 Finland
Diffuse diseases of connective tissue, Sclerosis systematica NUD
+∞
11.5
11
*
M81.9
ICD-10 Finland
Osteoporosis, unspecified
2.7
11.5
61
233
M33.2
ICD-10 Finland
Polymyositis
121.5
11.4
12
*
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
3.3
11.4
43
135
RT310, ,
NOMESCO Finland
35.5
11.3
14
*
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.6
11.2
37
106
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.4
11.2
41
126
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
11.2
121
632
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.0
11.1
31
79
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.4
11.1
39
117
TEA00
NOMESCO Finland
Biopsy of lip
10.2
11.0
21
21
A03FA02
ATC
cisapride; oral, rectal
2.4
11.0
79
349
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.1
10.9
46
154
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.1
10.9
117
609
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.8
10.8
54
199
XG466
NOMESCO Finland
Sleep oxymetry
3.6
10.8
35
99
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
10.7
139
773
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
10.7
280
1916
PB1BC
NOMESCO Finland
Extensive angiography of upper extremity with X-ray
60.7
10.6
12
*
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
10.6
69
291
S18
ICPC
Laceration/cut
1.6
10.6
409
3079
B02.9
ICD-10 Finland
Zoster without complication
2.4
10.6
74
323
I73.1
ICD-10 Finland
Thromboangiitis obliterans [Buerger]
+∞
10.4
10
*
J99.1
ICD-10 Finland
Respiratory disorders in other diffuse connective tissue disorders
+∞
10.4
10
*
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.7
10.4
56
215
WZC00
NOMESCO Finland
Treatment plan or consultation
1.6
10.3
332
2388
R4110
NOMESCO Finland
Physiotherapy
1.7
10.2
262
1779
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.8
10.2
173
1047
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
10.2
145
831
JGC01
NOMESCO Finland
Laparoscopic rectopexy
5.4
10.1
20
38
L84
ICD-10 Finland
Corns and callosities
3.1
10.0
42
141
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.8
10.0
51
191
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
7.7
9.9
22
29
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
16.9
9.9
15
9
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
9.9
359
2653
D07AC01
ATC
betamethasone; topical
1.6
9.8
328
2377
J01MA02
ATC
ciprofloxacin; systemic
1.6
9.6
326
2367
Z2221
NOMESCO Finland
Medical doctor
1.6
9.5
262
1807
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
101.1
9.4
10
*
I78.8
ICD-10 Finland
Other diseases of capillaries
101.1
9.4
10
*
M34.2
ICD-10 Finland
Systemic sclerosis induced by drugs and chemicals
+∞
9.4
9
*
383
Kela drug reimbursment
Selexipag
+∞
9.4
9
*
B01AC27
ATC
selexipag; oral
+∞
9.4
9
*
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
9.4
9
*
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.5
9.2
57
235
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
9.2
154
928
SAA03
NOMESCO Finland
Extended examination of mouth
1.6
9.2
355
2650
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.2
9.1
75
351
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
9.1
178
1121
GD2SN
NOMESCO Finland
Lung ventilation SPECT
9.2
9.1
18
20
SFA00
NOMESCO Finland
Small restoration
1.8
9.0
137
800
A06AC51
ATC
ispaghula, combinations; oral
2.5
9.0
55
225
A02BC03
ATC
lansoprazole; oral
1.6
9.0
276
1952
R76.0
ICD-10 Finland
Raised antibody titre
18.8
8.9
13
7
J01MA14
ATC
moxifloxacin; systemic
2.1
8.9
88
443
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
8.8
95
494
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
2.8
8.8
44
163
B80
ICPC
Iron deficiency anaemia
3.7
8.8
27
74
M25.5
ICD-10 Finland
Pain in joint
1.6
8.7
310
2263
C08DB01
ATC
diltiazem; oral
2.6
8.7
50
199
M35
ICD-10 Finland
Other systemic involvement of connective tissue
50.5
8.7
10
*
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.4
8.7
31
94
WZC30
NOMESCO Finland
Teaching
1.8
8.7
145
872
K11.71
ICD-10 Finland
Xerostomy (dry mouth)
4.8
8.6
19
40
R22.3
ICD-10 Finland
Localized swelling, mass and lump, upper limb
3.7
8.6
27
75
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.8
8.6
129
751
WX002
NOMESCO Finland
Sedation and analgesia
1.7
8.6
178
1138
SPAT1255
SPAT
Intravenous administration of medicine
2.4
8.6
59
256
M43.0
ICD-10 Finland
Spondylolysis
4.1
8.6
23
57
C03DA01
ATC
spironolactone; oral
1.9
8.5
106
580
G04BE08
ATC
tadalafil; oral
27.8
8.5
11
*
O99.89
ICD-10 Finland
Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium
4.2
8.5
22
53
NDQ48
NOMESCO Finland
Revision or amputation or exarticulation of finger
20.2
8.5
12
6
H03AA01
ATC
levothyroxine sodium; systemic
1.6
8.5
252
1765
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.2
8.4
71
337
M43.9
ICD-10 Finland
Deforming dorsopathy, unspecified
+∞
8.3
8
*
M32
ICD-10 Finland
Systemic lupus erythematosus
+∞
8.3
8
*
286
Kela drug reimbursment
Ciclosporin eye drop
+∞
8.3
8
*
PD4AD
NOMESCO Finland
CT of lower extremity arteries
9.6
8.3
16
17
TQW80
NOMESCO Finland
Local dermatologic skincare
3.4
8.3
29
87
SPAT1360
SPAT
Extensive global examination
2.2
8.2
66
306
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.9
8.2
108
602
D02AX
ATC
Other emollients and protectives
3.0
8.2
36
124
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
8.1
149
920
R60.0
ICD-10 Finland
Localized oedema
1.9
8.1
113
642
J01CA04
ATC
amoxicillin; systemic
1.7
8.1
736
6538
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.8
8.1
41
153
H19.3*M35.0
ICD-10 Finland
Keratoconjunctivitis sicca
33.7
8.1
10
*
EBA10
NOMESCO Finland
Operative extraction of tooth
2.0
8.1
95
510
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
8.0
265
1898
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.5
8.0
357
2729
NF1AA
NOMESCO Finland
Hip X-ray examination
2.0
8.0
84
434
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.1
8.0
33
110
E000003, ,
ATC
2.6
7.9
47
190
M05BB03
ATC
alendronic acid and colecalciferol; oral
3.1
7.9
32
105
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
8.5
7.8
16
19
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.7
7.8
139
850
Z3229
NOMESCO Finland
Other healthcare associate professional
2.1
7.8
75
375
L12
ICPC
Hand/finger symptom/complaint
1.7
7.7
159
1012
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.2
7.7
67
321
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
45.4
7.7
9
*
SPAT1211
SPAT
Application of soft bandage
2.0
7.7
82
425
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.9
7.7
101
563
E000006, ,
ATC
2.1
7.7
75
377
GX1D5
NOMESCO Finland
Flow volume spirometry
18.5
7.6
11
6
TQW99
NOMESCO Finland
Other minor procedure on skin
2.4
7.6
51
219
J05AB01
ATC
aciclovir; systemic
1.6
7.6
215
1483
NJ3CG
NOMESCO Finland
Extensive MRI examination of extremities with median high magnet
12.0
7.6
13
11
S20
ICPC
Corn/callosity
3.5
7.6
25
72
B01AC04
ATC
clopidogrel; oral
1.8
7.6
125
748
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
7.5
257
1850
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
7.2
7.5
17
24
E000002, ,
ATC
1.9
7.4
101
569
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.7
7.4
141
878
L94.9
ICD-10 Finland
Localized connective tissue disorder, unspecified
80.7
7.4
8
*
J01FA06
ATC
roxithromycin; oral
1.5
7.4
371
2890
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
2.7
7.4
39
149
GX1K5
NOMESCO Finland
Diffusion capacity
8.5
7.3
15
18
R02
ICPC
Shortness of breath/dyspnoea
1.8
7.3
118
701
RJ420, ,
NOMESCO Finland
11.0
7.3
13
12
TGD04
NOMESCO Finland
Needle biopsy of the lungs in bronchoscopy
11.0
7.3
13
12
73401
ICD-8 Finland
Diffuse diseases of connective tissue, Sclerosis systematica acrosclerotica
+∞
7.3
7
*
M31.1
ICD-10 Finland
Thrombotic microangiopathy
+∞
7.3
7
*
L94.3
ICD-10 Finland
Sclerodactyly
+∞
7.3
7
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
4.2
7.3
19
46
NFQ20
NOMESCO Finland
Amputation of femur
9.5
7.3
14
15
K76.9
ICD-10 Finland
Liver disease, unspecified
3.9
7.3
21
55
A10BA02
ATC
metformin; oral
0.6
7.3
98
1636
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.1
7.2
71
357
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
4.4
7.2
18
42
E000007, ,
ATC
2.2
7.2
57
263
NH1AE
NOMESCO Finland
Ankle joint ultrasound examination
7.4
7.2
16
22
NXL00
NOMESCO Finland
Biopsy of muscle
20.2
7.1
10
5
L17
ICPC
Foot/toe symptom/complaint
1.5
7.1
262
1912
SPAT1254
SPAT
Administration of medicine
1.7
7.1
123
746
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
6.1
7.1
18
30
K73.2
ICD-10 Finland
Chronic active hepatitis, not elsewhere classified
12.1
7.1
12
10
K07.65
ICD-10 Finland
Temporomandibular joint-pain-dysfunction syndrome
5.7
7.1
19
34
R81
ICPC
Pneumonia
2.9
7.1
33
118
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.8
7.1
102
586
Z3231
NOMESCO Finland
Registered nurse
1.5
7.0
233
1662
M70.2
ICD-10 Finland
Olecranon bursitis
3.1
7.0
29
97
S01
ICPC
Pain/tenderness of skin
2.4
7.0
45
190
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.0
6.9
76
398
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
3.2
6.9
27
87
L01AA01
ATC
cyclophosphamide; systemic
13.9
6.9
11
8
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
3.2
6.9
26
82
L28
ICPC
Limited function/disability (L)
1.6
6.9
153
993
M80.4
ICD-10 Finland
Drug-induced osteoporosis with pathological fracture
8.3
6.8
14
17
SPAT1070
SPAT
Doppler ultrasound examination of blood flow in arteries of lower extremity
3.8
6.8
20
53
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
6.8
6.8
16
24
RK220, ,
NOMESCO Finland
11.0
6.8
12
11
J01AA04
ATC
lymecycline; systemic
1.7
6.8
118
716
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.5
6.8
42
174
J94.8
ICD-10 Finland
Other specified pleural conditions
4.3
6.8
17
40
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
40.4
6.8
8
*
GDG10
NOMESCO Finland
Bilateral transplantation of lung
40.4
6.8
8
*
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
40.4
6.8
8
*
Z94.2
ICD-10 Finland
Lung transplant status
40.4
6.8
8
*
J01DA01
ATC
[U] cefalexin
1.4
6.7
556
4730
A46
ICD-10 Finland
Erysipelas
1.8
6.7
110
656
SPAT1325
SPAT
Vaccination
1.5
6.7
282
2112
SPAT1312
SPAT
General health counselling
1.5
6.7
268
1987
SPAT1229
SPAT
Assessment of need for aid
2.0
6.7
69
354
RT171, ,
NOMESCO Finland
22.7
6.7
9
*
XF622
NOMESCO Finland
Measurement of minute volume of heart
22.7
6.7
9
*
ADA20
NOMESCO Finland
Thoracal sympathectomy
22.7
6.7
9
*
SBB10
NOMESCO Finland
Dental impressions
2.1
6.7
60
292
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.8
6.6
112
675
L04AA13
ATC
[U] leflunomide
3.0
6.6
28
95
XQ848
NOMESCO Finland
Dermatological photography
2.9
6.6
30
106
D50.8
ICD-10 Finland
Other iron deficiency anaemias
4.2
6.6
17
41
L93.0
ICD-10 Finland
Discoid lupus erythematosus
8.8
6.6
13
15
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
2.4
6.6
43
183
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
6.9
6.5
15
22
D02AE01
ATC
carbamide; topical
2.1
6.5
62
309
I50.9
ICD-10 Finland
Heart failure, unspecified
1.8
6.5
91
518
TPH07
NOMESCO Finland
Cathetrisation of artery
1.8
6.5
91
519
UJF92
NOMESCO Finland
Capsular endoscopy
3.4
6.4
22
65
JDA52
NOMESCO Finland
Other endoscopic procedure using diathermy or heat in stomach or pylorus
70.3
6.4
7
*
M35.4
ICD-10 Finland
Diffuse (eosinophilic) fasciitis
70.3
6.4
7
*
73410
ICD-8 Finland
Diffuse diseases of connective tissue, Systemic lupus erythematosus
70.3
6.4
7
*
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
2.3
6.4
49
223
GD1UN
NOMESCO Finland
Lung circulation SPECT
7.5
6.4
14
19
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.6
6.4
169
1144
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
1.8
6.4
96
559
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
6.4
124
777
C01DA14
ATC
isosorbide mononitrate; oral
1.8
6.4
106
636
B07.9
ICD-10 Finland
Verruca simplex
2.6
6.3
35
137
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
5.2
6.3
18
35
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
5.2
6.3
18
35
K59.09
ICD-10 Finland
Constipation, unspecified
2.1
6.3
62
312
NDL52
NOMESCO Finland
Tenosynovectomy of hand
5.6
6.3
17
31
PHD76
NOMESCO Finland
Resection of long saphenous vein
2.2
6.3
51
238
ZX108
NOMESCO Finland
Inhalation
11.1
6.3
11
10
A07AA02
ATC
nystatin; oral
2.1
6.3
60
299
SAA04
NOMESCO Finland
Special examination of mouth
2.2
6.3
50
232
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
18.2
6.3
9
5
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
+∞
6.3
6
*
XQ844
NOMESCO Finland
Other microscope or electron microscope examination
+∞
6.3
6
*
N02BE01
ATC
paracetamol; systemic, rectal
1.7
6.1
807
7468
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
2.9
6.0
28
100
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
6.1
6.0
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
308
259
17.45
323.31
1.7
1.1
7.18
1.72
u/ml
2.62
25
17
529
980
11.47
315.52
1.9
1.3
1855.24
392.60
titre
39.69
357
200
283
196
20.49
307.65
2.2
1.1
1.08
1.23
g/l
7.77
271
183
383
172
37.67
307.65
1.7
1.1
8.83
3.77
u/ml
1.20
141
19
312
140
33.35
307.65
1.6
1.1
36.06
26.16
u/ml
0.29
53
11
362
123
48.14
307.65
1.6
1.1
32.40
16.24
u/ml
—
55
5
389
185
35.92
307.65
1.6
1.1
8.71
1.31
u/ml
—
27
7
329
210
23.94
307.65
2.4
1.3
—
—
—
0
0
283
186
21.61
307.65
2.3
1.1
0.20
0.25
g/l
6.22
270
176
284
129
31.52
307.65
1.5
1.1
0.41
—
u/ml
—
10
0
384
168
38.75
307.65
1.6
1.1
3.49
2.72
u/ml
—
96
10
628
2059
7.58
197.72
4.6
2.8
665.15
1020.64
ng/l
3.45
587
1721
119
46
29.60
174.99
1.4
1.1
—
—
—
0
0
119
46
29.60
174.99
1.4
1.1
—
—
—
0
0
119
47
28.97
173.65
1.4
1.1
—
—
—
0
0
119
47
28.97
173.65
1.4
1.1
—
—
—
0
0
119
47
28.97
173.65
1.4
1.1
—
—
—
0
0
94
20
52.29
162.67
2.5
1.2
8.57
8.78
ug/l
0.10
94
20
806
3936
10.01
148.81
14.0
5.5
0.19
0.19
e9/l
0.18
785
3440
801
3893
9.69
148.48
13.6
5.2
1.69
1.94
e9/l
7.63
781
3436
730
3556
6.28
125.11
13.8
5.4
3.00
2.80
%
1.71
722
3301
735
3632
6.27
122.84
13.3
5.2
58.13
56.67
%
3.19
726
3381
737
3669
6.26
121.49
13.9
5.4
27.34
28.56
%
2.83
728
3425
811
4459
8.39
116.82
16.6
8.7
3.84
3.96
e9/l
1.01
784
3887
545
2201
4.67
116.01
3.1
2.0
104.30
197.93
u/l
2.50
530
2065
238
518
5.86
108.51
3.5
2.8
10.33
10.19
g/l
0.15
222
471
69
23
32.37
105.68
1.2
1.1
—
—
—
0
0
84
49
18.78
103.53
1.4
1.1
40.57
—
u/ml
—
7
0
84
50
18.40
102.52
1.4
1.1
20.82
—
u/ml
—
17
0
239
550
5.53
101.96
4.4
2.9
114.16
168.05
ng/l
1.98
230
497
184
408
5.40
80.70
1.8
1.7
1.43
1.31
g/l
0.41
168
371
850
5801
7.84
71.64
11.4
3.7
12.57
12.08
mm/h
0.56
837
5360
657
3780
3.64
69.38
5.9
3.6
0.00
0.00
estimate
0.74
178
738
653
3803
3.52
66.27
7.7
4.9
0.00
0.00
estimate
0.50
175
694
656
3839
3.53
65.88
5.9
3.6
0.00
0.01
estimate
0.80
176
677
849
6043
6.86
61.32
14.2
7.0
75.81
78.06
u/l
0.67
841
5684
408
1882
3.11
60.38
3.5
2.4
1663.88
6097.45
umol/l
2.44
373
1646
589
3369
3.11
58.65
3.2
2.2
81.00
78.82
nmol/l
1.04
550
3020
334
1411
3.16
57.04
1.4
1.3
37.78
33.72
iu/ml
0.17
146
456
86
145
6.44
49.71
2.0
2.1
122.81
129.45
g/l
0.84
27
107
606
3765
2.82
47.41
8.2
6.1
1.22
1.22
mmol/l
0.58
518
3194
557
3407
2.63
43.40
7.4
5.3
1.22
1.22
mmol/l
0.41
523
3100
78
140
6.00
42.23
3.5
3.0
3.88
4.36
e9/l
1.10
78
140
319
1525
2.68
40.97
1.7
1.5
2.27
2.33
g/l
0.21
214
897
78
146
5.75
40.40
3.6
3.3
57.79
59.11
%
0.35
78
146
95
212
4.89
40.38
1.5
1.5
193.33
110.00
titre
—
6
8
55
73
7.95
39.43
2.2
2.4
—
—
—
0
0
88
192
4.97
38.38
2.4
2.6
—
—
—
0
0
64
106
6.42
37.50
1.4
1.2
5.37
4.89
u/ml
0.05
27
28
87
202
4.66
35.15
3.0
2.2
115.18
239.76
ug/l
2.42
81
188
279
1356
2.52
33.57
1.3
1.3
13.39
10.91
u/ml
0.22
114
516
60
108
5.88
32.29
1.4
1.2
4.29
6.50
u/ml
0.36
28
40
361
2002
2.33
32.05
7.2
3.9
0.00
0.00
estimate
0.80
177
684
40
12
34.79
31.15
1.3
1.1
—
—
—
0
0
42
54
8.10
30.85
1.8
1.4
—
—
—
0
0
236
1104
2.53
30.41
3.4
2.2
11.37
13.29
umol/l
3.33
227
1027
85
217
4.22
30.36
1.7
1.5
0.07
0.09
iu/ml
0.08
14
40
349
1982
2.23
28.55
4.0
2.8
0.20
0.45
e6/l
2.87
297
1492
206
932
2.56
28.27
3.4
2.3
20.17
22.48
%
1.53
178
802
284
1492
2.31
27.92
3.5
2.3
3.77
7.27
e6/l
4.99
271
1349
147
568
2.89
27.43
1.9
2.8
65.54
67.08
g/l
1.41
136
516
328
1842
2.22
27.34
3.5
2.1
3.09
3.03
mg/l
0.14
296
1562
458
2931
2.13
27.28
6.6
3.7
—
—
—
0
0
213
1006
2.46
26.50
3.3
2.2
2.34
2.38
g/l
0.43
203
928
358
2144
2.10
24.78
4.2
2.8
17.86
84.32
e6/l
1.37
310
1630
60
137
4.62
24.65
1.9
1.3
—
—
—
0
0
486
3262
2.05
24.58
6.2
4.3
35.51
35.92
g/l
0.94
463
3041
236
1204
2.30
24.42
3.0
2.4
0.66
1.17
e6/l
4.27
166
653
216
1102
2.26
22.11
2.4
1.8
—
—
—
0
0
54
124
4.57
22.02
1.8
1.4
—
—
—
0
0
30
39
7.92
21.78
1.3
1.2
—
—
—
0
0
30
40
7.72
21.32
1.9
2.4
—
—
—
0
0
46
95
5.05
21.27
1.9
1.4
—
—
—
0
0
64
172
3.93
21.24
2.0
1.5
—
—
—
0
0
556
4048
1.96
20.87
7.7
5.9
10.01
10.67
umol/l
0.87
530
3835
62
165
3.96
20.86
2.0
1.5
—
—
—
0
0
50
118
4.43
19.70
12.0
4.6
1649.31
161.80
iu/ml
0.78
16
15
151
694
2.41
19.50
1.7
2.0
351.02
379.59
nmol/l
0.67
139
635
151
700
2.39
19.11
2.8
2.0
0.20
0.22
g/l
2.08
139
664
158
766
2.29
17.97
2.6
2.5
1.91
1.83
%
0.37
144
694
468
3322
1.84
17.89
14.8
12.9
1.14
1.19
inr
0.96
146
950
47
114
4.29
17.89
1.9
1.4
—
—
—
0
0
47
114
4.29
17.89
1.9
1.4
—
—
—
0
0
79
272
3.09
17.89
1.9
2.1
—
—
—
0
0
46
110
4.35
17.83
1.6
1.4
—
—
—
0
0
294
1811
1.92
17.52
1.3
1.3
0.52
1.53
u/ml
2.68
69
479
872
7763
3.81
17.39
27.3
12.6
17.22
22.03
mg/l
5.49
757
6029
152
747
2.24
16.66
3.1
4.4
254.31
256.27
u/l
0.04
147
707
47
123
3.97
16.18
2.1
1.5
—
—
—
0
0
24
34
7.22
16.16
1.4
1.1
1.11
1.08
ratio
—
10
12
171
895
2.12
15.96
5.5
4.7
1.03
1.04
mmol/l
0.22
158
826
115
514
2.42
15.66
2.0
1.5
—
—
—
0
0
152
770
2.17
15.39
2.2
1.7
—
—
—
0
0
465
3392
1.76
15.36
3.8
2.7
106.40
105.39
ug/l
0.04
434
3143
36
80
4.64
15.28
1.8
1.6
54.43
58.72
%
0.23
21
50
39
93
4.34
15.18
1.6
1.4
—
—
—
0
0
40
98
4.22
15.04
1.3
1.5
125.21
115.25
u/ml
—
7
19
27
47
5.89
14.99
1.4
1.1
117.50
62.86
titre
—
8
7
263
1642
1.85
14.59
6.9
4.0
1.01
1.02
kg/l
1.15
36
234
150
779
2.11
14.18
2.2
1.7
—
—
—
0
0
24
40
6.14
13.91
1.5
2.4
353.47
488.18
e6/l
0.76
19
34
27
51
5.43
13.78
1.8
1.7
40.37
37.36
%
0.11
12
30
228
1388
1.86
13.57
4.6
3.7
257.03
303.74
ng/l
0.17
183
1028
390
2801
1.69
12.91
4.7
3.3
24.24
44.54
ng/l
0.86
275
1827
174
985
1.95
12.87
1.8
2.1
186.70
130.62
ug/g
0.88
143
772
143
757
2.05
12.78
10.3
7.5
4.81
5.10
kpa
3.04
137
729
27
55
5.03
12.69
1.4
1.2
—
—
—
0
0
74
297
2.62
12.60
2.0
1.8
1.52
1.52
g/l
0.00
66
259
357
2527
1.68
12.34
5.0
3.0
30.76
31.68
u/l
0.23
344
2401
53
185
2.98
11.73
1.6
1.4
—
—
—
0
0
61
231
2.76
11.64
1.5
1.4
297.68
306.90
ug/g
0.13
33
128
140
760
1.99
11.62
10.6
7.5
1.09
1.22
mmol/l
0.16
114
612
28
64
4.48
11.51
1.3
1.4
—
—
—
0
0
28
64
4.48
11.51
1.3
1.4
—
—
—
0
0
28
64
4.48
11.51
1.3
1.4
—
—
—
0
0
26
56
4.75
11.47
1.7
1.3
2539.63
1734.22
e6/l
0.35
16
36
620
5108
1.67
11.38
6.3
4.4
163.33
1142.95
e6/l
—
9
66
339
2406
1.65
11.37
3.0
2.3
58.92
60.86
u/l
0.26
309
2211
41
126
3.36
11.20
1.5
1.2
—
—
—
0
0
119
619
2.06
11.10
3.7
3.5
1.23
1.23
mmol/l
0.61
110
534
30
75
4.10
11.01
2.2
1.4
—
—
—
0
0
30
75
4.10
11.01
2.2
1.4
—
—
—
0
0
37
108
3.53
10.94
1.2
1.1
—
—
—
0
0
106
537
2.10
10.59
9.3
6.7
8.93
8.98
mmol/l
0.03
99
514
261
1761
1.68
10.50
1.7
1.5
22.04
21.86
nmol/l
0.05
228
1492
409
3092
1.59
10.31
2.1
1.9
95.43
96.91
pmol/l
0.23
203
1517
50
182
2.85
10.28
1.1
1.2
—
—
—
0
0
367
2710
1.59
10.20
3.2
3.5
2.35
2.36
mmol/l
1.20
324
2409
208
1333
1.73
10.07
1.7
1.7
1181.71
1211.99
nmol/l
0.18
166
981
187
1163
1.76
10.07
5.0
3.1
0.81
0.82
mmol/l
0.30
172
1099
20
22
9.27
10.05
1.7
1.3
—
—
—
0
0
145
836
1.87
10.00
2.7
2.5
5.75
7.27
umol/l
0.72
131
721
23
51
4.60
9.81
1.7
1.3
6241.75
176288.00
e6/l
0.69
12
27
53
206
2.67
9.64
2.2
3.7
1.16
2.06
ratio
—
5
20
54
212
2.64
9.63
2.2
3.7
68.40
76.74
mg/l
0.08
47
165
63
267
2.46
9.61
2.1
1.9
1.20
2.18
ug/l
0.43
55
242
26
65
4.09
9.56
1.8
1.5
—
—
—
0
0
50
193
2.68
9.23
3.3
2.6
3.52
3.61
g/l
0.20
50
188
53
212
2.59
9.12
2.3
3.7
27.14
41.62
mg/l
0.48
45
165
269
1888
1.60
9.03
5.8
3.6
91.98
93.57
%
0.52
258
1837
19
39
4.95
8.86
1.3
1.4
—
—
—
0
0
19
39
4.95
8.86
1.3
1.4
—
—
—
0
0
28
79
3.62
8.73
2.6
1.5
—
—
—
0
0
32
101
3.25
8.42
2.2
1.4
—
—
—
0
0
34
112
3.11
8.35
1.2
1.3
321.24
255.98
u/ml
0.60
21
65
26
72
3.69
8.33
1.8
1.4
—
—
—
0
0
79
392
2.11
8.33
5.7
3.2
1.82
1.93
mmol/l
0.10
58
301
16
17
9.56
8.30
2.4
2.1
—
—
—
0
0
245
1732
1.57
7.81
2.1
1.7
1.46
1.02
mg/l
0.70
200
1327
35
123
2.92
7.71
1.2
1.3
—
—
—
0
0
524
4346
1.48
7.70
7.0
4.3
6.40
6.62
mmol/l
1.53
504
4065
13
11
11.97
7.59
3.2
7.5
—
—
—
0
0
19
45
4.29
7.50
2.9
3.0
47.00
39.09
%
0.82
14
23
575
4877
1.48
7.42
3.1
3.0
—
—
—
0
0
13
12
10.97
7.31
1.0
1.1
100.38
104.42
%
0.17
13
12
58
269
2.23
7.25
2.4
1.8
—
—
—
0
0
46
193
2.46
7.21
1.7
1.6
—
—
—
0
0
169
1113
1.64
7.19
3.5
2.6
2.89
3.40
e6/l
0.22
97
563
41
163
2.59
7.18
1.7
1.7
4101.38
12970.65
e6/l
1.45
34
118
31
106
2.99
7.18
1.5
1.3
—
—
—
0
0
93
518
1.89
7.10
1.4
1.2
77.84
207.69
u/ml
1.92
86
476
41
165
2.55
7.01
1.1
1.5
—
—
—
0
0
47
203
2.39
6.93
1.3
1.2
—
—
—
0
0
17
28
6.17
6.79
1.1
1.5
—
—
—
0
0
17
28
6.17
6.79
1.1
1.5
—
—
—
0
0
17
28
6.17
6.79
1.1
1.5
—
—
—
0
0
30
105
2.92
6.68
3.4
3.0
1.23
1.29
%
0.03
30
96
96
551
1.83
6.67
2.5
2.4
38.64
30.99
au/ml
—
8
42
53
247
2.22
6.57
2.0
1.8
—
—
—
0
0
88
496
1.86
6.48
1.4
1.3
45.94
38.69
au/ml
—
7
37
27
92
2.99
6.31
1.1
1.1
—
—
—
0
0
708
6350
1.51
6.26
4.7
4.2
15.21
14.72
pmol/l
6.41
657
5809
21
62
3.44
6.17
1.6
1.5
2103.67
124874.93
e6/l
0.61
15
41
18
48
3.81
6.11
2.1
1.0
—
—
—
0
0
220
1600
1.49
5.95
1.6
1.7
32609153.61
24621655.33
pmol/l
0.09
184
1320
17
35
4.93
5.76
1.1
1.2
—
—
—
0
0
33
132
2.56
5.75
4.0
2.3
13.88
16.27
%
1.79
22
63
22
71
3.15
5.64
1.2
1.2
—
—
—
0
0
16
33
4.92
5.44
1.6
1.4
1.40
7.00
%
—
5
8
101
626
1.69
5.39
4.1
3.2
1.62
1.99
mmol/l
0.50
84
514
98
608
1.69
5.22
2.8
2.4
65.93
66.76
ml/min/173m2
0.07
46
247
11
15
7.41
5.15
1.5
1.1
—
—
—
0
0
10
13
7.76
4.85
1.3
1.3
—
—
—
0
0
33
144
2.34
4.82
1.5
1.6
—
—
—
0
0
96
606
1.65
4.79
3.6
3.4
77.03
80.76
ng/l
0.22
80
530
68
393
1.79
4.66
1.7
1.6
—
—
—
0
0
57
314
1.87
4.56
4.8
3.2
23.63
24.21
mmol/l
0.86
57
306
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
40
199
2.06
4.29
3.3
3.1
0.38
0.38
u/ml
0.02
23
110
35
166
2.15
4.24
1.3
1.3
—
—
—
0
0
790
7403
1.50
4.22
5.8
5.0
2.06
2.05
mu/l
0.01
739
6800
91
594
1.59
3.99
2.5
2.3
16.96
6.41
ug/l
0.56
74
521
18
65
2.80
3.87
3.8
2.5
59.94
57.95
%
0.13
18
59
47
258
1.87
3.83
1.9
1.6
—
—
—
0
0
13
33
3.98
3.80
1.2
1.1
—
—
—
0
0
67
410
1.68
3.80
1.6
1.5
—
—
—
0
0
14
45
3.14
3.66
2.3
1.3
—
—
—
0
0
16
56
2.89
3.64
1.7
2.4
—
—
—
0
0
17
62
2.78
3.60
2.1
1.5
—
—
—
0
0
20
80
2.53
3.56
4.1
3.3
—
—
—
0
0
14
46
3.08
3.54
2.3
1.3
—
—
—
0
0
9
17
5.34
3.51
1.9
2.1
—
—
—
0
0
11
26
4.27
3.51
1.5
1.5
1.75
2.13
umol/l
0.75
11
26
28
134
2.12
3.36
4.2
2.9
37.04
34.01
umol/l
0.23
23
121
18
71
2.57
3.31
1.1
1.1
—
—
—
0
0
8
15
5.37
3.19
1.3
1.1
—
—
—
0
0
11
29
3.83
3.19
1.5
3.8
981.36
1465.17
u/ml
0.37
11
29
14
50
2.83
3.09
2.3
1.3
—
—
—
0
0
6
8
7.54
3.06
3.3
1.4
—
—
—
0
0
6
8
7.54
3.06
1.0
1.4
—
—
—
0
0
22
100
2.23
3.01
1.1
1.1
—
—
—
0
0
99
706
1.45
2.92
2.4
2.2
31.37
36.48
u/l
0.84
88
591
7
13
5.42
2.87
1.3
1.2
—
—
—
0
0
184
1460
1.33
2.85
2.7
2.8
2.46
2.46
mmol/l
0.28
162
1309
412
3624
1.25
2.80
3.4
2.4
—
—
—
0
0
55
349
1.61
2.77
3.1
2.4
0.15
0.20
e6/l
0.24
55
335
44
693
0.62
2.56
1.5
1.7
—
—
—
0
0
30
165
1.85
2.51
1.2
1.5
2.26
11.50
e6/l
1.30
23
125
30
165
1.85
2.51
1.3
1.6
436.50
613.91
e6/l
0.14
24
132
102
753
1.40
2.51
4.6
3.1
—
—
—
0
0
16
69
2.34
2.49
2.3
2.1
—
—
—
0
0
781
7456
1.33
2.39
21.7
12.0
81.11
81.16
ml/min/173m2
0.02
720
6106
223
1860
1.26
2.34
3.0
2.2
—
—
—
0
0
26
141
1.87
2.29
1.4
1.3
—
—
—
0
0
26
141
1.87
2.29
1.4
1.3
—
—
—
0
0
10
35
2.88
2.21
1.1
1.2
—
—
—
0
0
10
35
2.88
2.21
1.1
1.2
—
—
—
0
0
10
37
2.72
2.07
1.7
1.3
25.60
30.38
umol/l
—
10
37
6
163
0.36
2.02
1.3
1.5
—
—
—
0
0
828
8012
1.36
1.98
23.7
14.5
139.30
139.71
mmol/l
3.95
818
7811
19
98
1.96
1.96
1.4
1.3
—
—
—
0
0
19
98
1.96
1.96
1.4
1.3
—
—
—
0
0
5
11
4.56
1.94
1.0
1.1
—
—
—
0
0
8
27
2.98
1.94
3.6
5.1
—
—
—
0
0
8
27
2.98
1.94
1.3
1.1
—
—
—
0
0
19
99
1.94
1.91
1.4
1.3
—
—
—
0
0
19
100
1.92
1.86
1.4
1.3
—
—
—
0
0
19
100
1.92
1.86
1.4
1.3
—
—
—
0
0
9
35
2.59
1.80
1.0
1.0
—
—
—
0
0
827
8033
1.32
1.64
23.9
14.6
3.93
3.95
mmol/l
0.80
816
7817
34
222
1.55
1.61
1.3
1.3
217.10
224.77
miu/ml
0.05
16
108
18
99
1.83
1.58
1.4
1.3
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
9
37
2.45
1.48
1.2
2.0
102.33
125.41
%
—
9
37
11
52
2.13
1.45
1.0
1.0
—
—
—
0
0
16
88
1.83
1.42
2.9
2.2
32.81
31.88
pg
0.33
16
88
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
43
2.10
1.30
1.0
1.1
—
—
—
0
0
114
954
1.22
1.19
8.9
6.6
—
—
—
0
0
8
39
2.06
1.15
3.6
3.5
—
—
—
0
0
8
153
0.52
1.15
1.1
1.4
—
—
—
0
0
8
153
0.52
1.15
1.1
1.4
—
—
—
0
0
8
153
0.52
1.15
1.1
1.4
—
—
—
0
0
8
153
0.52
1.15
1.1
1.4
—
—
—
0
0
16
257
0.62
1.12
1.3
1.5
—
—
—
0
0
539
5110
1.13
1.09
4.3
3.0
55.97
46.23
u/l
1.85
508
4777
10
178
0.56
1.04
1.5
1.5
—
—
—
0
0
876
8636
1.36
1.04
40.8
19.2
39.57
39.74
%
0.47
822
8120
39
291
1.36
1.01
2.1
3.0
23.94
900.82
u/ml
1.03
32
256
28
198
1.43
0.98
1.5
1.3
—
—
—
0
0
186
1655
1.16
0.98
1.4
1.4
—
—
—
0
0
876
8642
1.35
0.97
40.3
19.2
261.52
257.92
e9/l
0.89
871
8433
9
50
1.81
0.96
1.0
1.3
2.51
2.09
mmol/l
—
9
50
6
116
0.51
0.94
2.0
1.6
—
—
—
0
0
876
8645
1.34
0.94
40.3
19.2
4.36
4.44
e12/l
6.57
870
8411
27
193
1.41
0.91
1.2
1.1
—
—
—
0
0
6
29
2.08
0.89
1.0
1.0
—
—
—
0
0
159
1411
1.15
0.88
1.7
1.5
—
—
—
0
0
6
33
1.82
0.79
1.0
2.4
—
—
—
0
0
0
25
0.00
0.79
0.0
2.4
—
2.24
—
0
12
0
28
0.00
0.76
0.0
1.2
—
—
—
0
0
13
83
1.57
0.75
15.7
6.6
12.80
12.24
mg/l
0.15
13
77
29
219
1.33
0.74
1.4
2.0
2214.21
3223.78
u/l
—
9
86
7
38
1.85
0.73
2.1
1.6
—
—
—
0
0
10
60
1.67
0.72
1.1
1.2
—
—
—
0
0
10
60
1.67
0.72
1.1
1.2
—
—
—
0
0
34
265
1.29
0.71
2.0
2.1
12.91
12.39
nmol/l
0.11
27
237
32
248
1.30
0.69
1.3
1.2
—
—
—
0
0
5
27
1.86
0.68
1.2
1.2
—
—
—
0
0
40
321
1.26
0.67
1.5
1.5
—
—
—
0
0
6
103
0.58
0.62
1.0
1.5
—
—
—
0
0
43
353
1.23
0.61
1.6
1.4
—
—
—
0
0
709
7244
0.90
0.61
5.1
5.5
38.44
39.44
mmol/mol
1.17
664
6716
10
64
1.57
0.58
1.4
1.3
—
—
—
0
0
31
247
1.26
0.57
1.3
1.2
—
—
—
0
0
62
718
0.85
0.56
1.8
1.9
—
—
—
0
0
62
533
1.18
0.56
1.8
3.1
4.18
4.48
pmol/l
1.97
51
471
31
249
1.25
0.54
1.3
1.7
—
—
—
0
0
6
38
1.58
0.54
1.2
1.2
—
—
—
0
0
6
38
1.58
0.54
1.2
1.2
—
—
—
0
0
16
117
1.37
0.52
1.2
1.1
—
—
—
0
0
7
47
1.49
0.47
1.3
1.0
—
—
—
0
0
7
48
1.46
0.47
1.6
1.1
—
—
—
0
0
11
77
1.43
0.45
1.1
1.1
—
—
—
0
0
5
31
1.62
0.43
3.4
2.6
33664.40
38422.74
ug/l
—
5
31
27
221
1.23
0.42
1.4
1.2
—
—
—
0
0
5
33
1.52
0.41
1.2
1.2
—
—
—
0
0
5
33
1.52
0.41
1.2
1.2
—
—
—
0
0
7
106
0.66
0.39
1.3
1.8
—
—
—
0
0
9
71
1.27
0.36
1.1
1.0
—
—
—
0
0
29
245
1.19
0.35
1.7
1.6
352.25
299.79
mu/l
0.45
24
219
6
43
1.40
0.35
1.0
1.1
131.17
510.59
u/l
—
6
37
11
82
1.35
0.34
1.1
1.1
—
—
—
0
0
223
2128
1.06
0.33
1.6
1.6
1.30
1.36
mmol/l
0.59
182
1805
66
598
1.11
0.33
1.1
1.2
117.13
144.56
iu/ml
0.23
17
248
10
74
1.36
0.32
2.4
1.8
159.40
202.70
pmol/l
—
10
69
43
380
1.14
0.31
1.9
1.8
—
—
—
0
0
14
175
0.80
0.31
2.0
2.2
31.05
83.44
ug/min
—
6
101
7
53
1.32
0.31
1.1
1.4
97.57
74.02
umol/l
—
7
53
47
421
1.12
0.29
1.0
1.0
—
—
—
0
0
105
984
1.08
0.27
4.1
4.4
34.08
32.91
%
0.51
79
648
14
113
1.24
0.26
1.1
1.0
0.32
2.14
u/ml
—
8
53
81
754
1.08
0.25
3.9
4.2
20.21
21.89
%
0.53
37
347
46
418
1.11
0.23
1.5
1.4
—
—
—
0
0
39
432
0.90
0.23
1.5
1.3
33.96
31.53
iu/l
0.15
32
361
14
116
1.21
0.22
1.4
1.1
—
12.84
—
0
10
59
636
0.92
0.21
1.7
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
222
2293
0.96
0.21
3.9
3.6
20.31
7.09
mg/mmol
1.18
137
1356
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
49
1.23
0.20
1.5
1.9
—
—
—
0
0
6
49
1.23
0.20
2.0
1.9
—
—
—
0
0
85
807
1.06
0.17
2.4
4.0
4.40
28.97
ug/l
1.58
66
638
8
68
1.18
0.16
1.3
1.7
12.06
18.48
ug/l
—
8
68
16
139
1.15
0.16
1.1
1.1
0.49
1.64
u/ml
—
10
70
33
302
1.10
0.16
1.7
1.7
—
—
—
0
0
785
7802
1.04
0.15
4.3
4.4
4.63
4.80
mmol/l
4.85
738
7231
7
88
0.79
0.14
1.9
2.5
106.57
105.39
mmol/l
—
7
88
5
46
1.09
0.09
1.0
1.0
422.20
348.79
ng/l
—
5
28
5
46
1.09
0.09
1.0
1.0
57.40
51.26
ng/l
—
5
28
5
46
1.09
0.09
1.0
1.0
1115.00
686.78
ng/l
—
5
27
766
7627
1.03
0.09
4.3
4.5
5.59
5.88
mmol/l
10.55
712
6946
7
81
0.86
0.07
1.1
1.2
—
—
—
0
0
9
105
0.86
0.06
1.0
1.1
—
—
—
0
0
752
7497
1.02
0.05
3.8
3.9
1.18
1.27
mmol/l
4.81
704
6849
12
110
1.09
0.05
1.3
1.5
—
—
—
0
0
98
966
1.02
0.03
4.7
4.6
2.37
2.29
ug/l
0.05
87
858
778
7765
1.01
0.03
4.2
4.3
1.60
1.54
mmol/l
2.88
728
7155
18
171
1.05
0.03
1.9
1.6
—
—
—
0
0
15
157
0.95
0.01
5.5
1.6
0.78
0.81
nmol/l
0.10
15
129
217
2179
0.99
0.01
3.4
3.1
1664.41
325.04
mg/l
1.21
135
1292
15
156
0.96
0.00
3.9
3.6
26.00
21.69
mg/l
—
8
97
82
814
1.01
0.00
1.4
1.7
1.54
1.40
%
0.97
65
718
229
2294
1.00
0.00
3.3
3.0
6.43
6.96
mmol/l
1.16
195
1948
56
558
1.00
0.00
2.9
2.9
0.60
0.72
ug/l
0.70
32
347
795
7948
1.00
0.00
4.7
4.9
2.64
2.83
mmol/l
7.55
746
7341
0
8
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_SYSTSLCE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTSLCE | 2.306 [2.03, 2.62] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.224 |
During the follow-up period (1.1.1998 — 31.12.2019), 615 out of 2768 females with M13_SYSTSLCE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_SYSTSLCE | 2.516 [2.0, 3.17] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.068 |
During the follow-up period (1.1.1998 — 31.12.2019), 197 out of 642 males with M13_SYSTSLCE died.
Mortality risk
Mortality risk for people of age
years, who have M13_SYSTSLCE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.252% | 0.559% |
| 5 | 1.311% | 3.123% |
| 10 | 3.181% | 8.172% |
| 15 | 6.414% | 15.352% |
| 20 | 11.51% | 24.944% |
Relationships between endpoints
↥Index endpoint: M13_SYSTSLCE – Systemic sclerosis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data