No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
533 |
4. Check minimum number of eventsNone |
533 |
5. Include endpointsNone |
533 |
6. Filter based on genotype QC (FinnGen only) |
533 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M34
- Name in latin
- Syndroma CREST
Similar endpoints
↥List of similar endpoints to
CR(E)ST syndrome
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis, icd10
- Systemic sclerosis
- Systemic sclerosis (FG)
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2272 | 1946 | 313 |
| Only index persons | 2112 | 1834 | 278 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.01 |
| Only index persons | 0.06 | 0.07 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.34 | 58.28 | 59.14 |
| Only index persons | 57.94 | 57.80 | 58.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 533 | 467 | 66 |
| Unadjusted period prevalence (%) | 0.14 | 0.16 | 0.03 |
| Median age at first event (years) | 56.74 | 56.79 | 56.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 479
- Matched controls
- 4788
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
323.0
479
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
23.3
186.8
313
358
C08CA05
ATC
nifedipine; systemic
34.9
180.5
244
138
P01BA02
ATC
hydroxychloroquine; oral
21.0
165.0
277
293
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
447.3
136.1
130
*
I73.0
ICD-10 Finland
Raynaud syndrome
61.8
122.1
141
32
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
10.3
87.9
198
306
XX9XE
NOMESCO Finland
Other ultrasound examination
54.3
81.1
96
22
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
10.6
68.6
145
188
M34.0
ICD-10 Finland
Progressive systemic sclerosis
734.2
66.6
64
*
XPX04
NOMESCO Finland
Angioscopy
114.9
64.8
69
7
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
41.5
64.1
80
23
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.1
60.6
153
262
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.8
54.5
258
938
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
5.2
52.2
202
586
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
11.1
50.1
100
111
L04AA06
ATC
mycophenolic acid; systemic
29.9
48.3
65
25
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.5
47.2
97
113
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
43.8
305
1475
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
241.6
43.7
44
*
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
217.7
39.5
40
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
13.3
34.2
61
52
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
11.1
32.0
62
63
XG410
NOMESCO Finland
Flow-volume spirometry
10.1
30.8
63
71
L88
ICPC
Rheumatoid/seropositive arthritis
8.3
30.3
70
97
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.9
30.0
108
267
L04AX01
ATC
azathioprine; systemic
8.1
29.9
70
99
M35.1
ICD-10 Finland
Other overlap syndromes
53.7
29.8
35
7
G04BE03
ATC
sildenafil; oral
60.8
29.5
34
6
H02AB06
ATC
prednisolone; systemic
2.8
26.0
289
1674
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.0
25.4
88
207
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
12.3
25.2
46
41
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
263.2
24.9
25
*
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
36.7
24.6
31
9
C08CA02
ATC
felodipine; oral
4.4
21.9
85
223
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
10.0
21.8
44
48
NH3EA
NOMESCO Finland
Feet X-ray examination with load
9.2
20.4
43
51
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.8
20.4
94
288
K74.3
ICD-10 Finland
Primary biliary cirrhosis
30.4
19.8
26
9
C08CA01
ATC
amlodipine; oral
2.5
19.4
212
1147
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
8.1
19.4
44
59
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
19.2
234
1340
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
19.7
18.9
28
15
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.2
18.8
76
206
M34
ICD-10 Finland
Systemic sclerosis
197.4
18.7
19
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
12.7
17.6
31
26
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.0
17.5
115
453
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
8.8
16.8
36
44
R06.0
ICD-10 Finland
Dyspnoea
2.5
16.6
161
802
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
15.9
257
1635
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
12.3
15.8
28
24
C02KX01
ATC
bosentan; oral
165.2
15.6
16
*
A05AA02
ATC
ursodeoxycholic acid; oral
9.9
15.2
30
32
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.8
15.1
38
60
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.7
15.0
70
214
M01CC01
ATC
penicillamine; oral
58.6
14.9
17
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
26.0
14.8
20
8
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
14.1
79
278
SBA10
NOMESCO Finland
Measurement of excretion of saliva
14.1
13.9
23
17
E0000UV
ATC
NA
2.1
13.8
231
1460
C02KX04
ATC
macitentan; oral
+∞
13.6
13
*
R4120
NOMESCO Finland
Occupational therapy
3.8
13.5
59
171
L04AD01
ATC
ciclosporin; systemic
9.5
13.4
27
30
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
19.7
13.0
19
10
RT172
NOMESCO Finland
NA
51.5
12.9
15
*
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
4.4
12.8
47
116
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
12.6
12
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.3
12.1
63
210
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
11.9
223
1450
GD1AD
NOMESCO Finland
Thorax CT examination
5.1
11.7
37
78
RT160
NOMESCO Finland
NA
66.6
11.7
13
*
TGC00
NOMESCO Finland
Bronchial lavation
7.0
11.6
28
42
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
+∞
11.5
11
*
K62.3
ICD-10 Finland
Rectal prolapse
10.4
11.1
21
21
WZA10
NOMESCO Finland
Long statement of health and health related matters
10.4
11.1
21
21
D06BX01
ATC
metronidazole; topical
2.7
11.1
82
344
NHQ40
NOMESCO Finland
Amputation of toe
13.3
10.7
18
14
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.5
10.7
50
154
L04AA01
ATC
[U] ciclosporin; systemic
10.4
10.6
20
20
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.9
10.5
65
245
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
+∞
10.5
10
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.7
10.3
45
131
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.7
10.2
44
127
J01FF01
ATC
clindamycin; systemic
2.0
10.1
161
967
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.2
10.0
53
180
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
9.8
127
700
A02BC02
ATC
pantoprazole; systemic
1.9
9.8
340
2688
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
9.7
112
587
I27.0
ICD-10 Finland
Primary pulmonary hypertension
56.2
9.7
11
*
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
102.0
9.4
10
*
K22.7
ICD-10 Finland
Barrett oesophagus
11.0
9.4
17
16
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
11.8
9.1
16
14
R13
ICD-10 Finland
Dysphagia
3.1
9.0
48
164
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
9.7
8.8
17
18
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
9.7
8.8
17
18
A02BC01
ATC
omeprazole; systemic
1.9
8.6
149
911
RT274
NOMESCO Finland
NA
16.6
8.6
13
8
K22.1
ICD-10 Finland
Ulcer of oesophagus
8.1
8.4
18
23
C02DE02
ATC
NA
11.0
8.3
15
14
RT272
NOMESCO Finland
NA
11.0
8.3
15
14
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.4
8.2
28
66
UJF32
NOMESCO Finland
Coloscopy
1.9
8.1
141
860
R15
ICD-10 Finland
Faecal incontinence
4.3
8.1
29
71
A10BA02
ATC
metformin; oral
0.4
8.1
35
797
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.7
7.9
33
93
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
13.3
7.9
13
10
ZX120
NOMESCO Finland
Intravenous
2.6
7.9
59
247
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.7
7.8
33
94
SPAT1263
SPAT
Sampling
1.8
7.8
211
1486
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
9.6
7.8
15
16
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
9.6
7.8
15
16
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
7.7
204
1424
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
5.3
7.6
22
43
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
12.1
7.6
13
11
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.8
7.6
48
183
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.7
7.5
52
210
A02BC05
ATC
esomeprazole; systemic
1.7
7.5
221
1596
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
4.1
7.4
27
68
M31.4
ICD-10 Finland
Aortic arch syndrome [Takayasu]
+∞
7.3
7
*
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
7.2
61
273
J01AA04
ATC
lymecycline; systemic
2.2
7.2
77
387
RT231
NOMESCO Finland
NA
30.5
7.2
9
*
RT310
NOMESCO Finland
NA
20.4
7.2
10
5
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.3
7.2
64
297
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
4.0
7.1
27
71
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.5
7.1
31
92
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
5.1
7.1
21
43
C08DB01
ATC
diltiazem; oral
3.5
7.0
31
93
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
7.0
107
622
A02BC03
ATC
lansoprazole; oral
1.8
7.0
156
1028
RT271
NOMESCO Finland
NA
14.0
6.9
11
8
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
6.9
96
538
SAA03
NOMESCO Finland
Extended examination of mouth
1.7
6.9
189
1326
M05BX04
ATC
denosumab; parenteral
3.0
6.8
39
139
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.5
6.8
19
36
SPAT1312
SPAT
General health counselling
1.8
6.8
155
1026
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.3
6.8
63
295
NGQ20
NOMESCO Finland
Amputation of lower leg
40.6
6.8
8
*
K74.5
ICD-10 Finland
Biliary cirrhosis, unspecified
40.6
6.8
8
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.3
6.7
63
298
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
6.7
70
349
SPAT1255
SPAT
Intravenous administration of medicine
3.1
6.7
35
119
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
22.9
6.7
9
*
NDQ20
NOMESCO Finland
Amputation of finger
22.9
6.7
9
*
K76.9
ICD-10 Finland
Liver disease, unspecified
6.6
6.7
16
25
S09
ICPC
Infected finger/toe
4.2
6.7
24
60
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
6.6
58
267
H02AB07
ATC
prednisone; oral
2.1
6.6
81
432
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.2
6.5
68
336
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.7
6.5
148
977
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.4
6.5
22
52
J01MA12
ATC
levofloxacin; systemic
2.0
6.5
86
474
ADA20
NOMESCO Finland
Thoracal sympathectomy
70.8
6.4
7
*
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
5.0
6.4
19
39
EBA10
NOMESCO Finland
Surgical removal of tooth
2.5
6.4
50
214
J01AA07
ATC
tetracycline; systemic
2.0
6.4
83
451
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
9.4
6.3
12
13
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.8
6.3
40
153
383
Kela drug reimbursment
Selexipag
+∞
6.3
6
*
B01AC27
ATC
selexipag; oral
+∞
6.3
6
*
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
6.3
6
*
RT171
NOMESCO Finland
NA
27.1
6.2
8
*
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
6.2
340
2847
L95
ICPC
Osteoporosis
3.3
6.1
29
92
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.3
6.1
56
262
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.5
6.0
45
189
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
257
157
30.68
307.65
1.6
1.2
4.6
16.3
u/ml
—
16
10
237
108
38.71
307.65
1.5
1.3
18.5
13.5
u/ml
—
32
7
254
143
33.02
307.65
1.6
1.2
2.6
2.3
u/ml
0.11
68
15
254
145
32.55
307.65
1.7
1.2
4.8
6.8
u/ml
0.23
96
25
204
119
27.15
262.69
1.7
1.2
28.1
44.0
u/ml
0.38
34
14
177
108
24.04
221.35
1.5
1.2
0.4
—
u/ml
—
8
0
199
169
18.20
209.10
2.3
1.8
—
—
—
0
0
185
192
14.23
169.64
1.7
1.3
7.9
1.0
u/ml
3.04
17
11
161
144
15.59
161.73
2.0
1.7
0.2
0.2
g/l
4.66
151
139
161
152
14.74
156.15
2.0
1.6
1.0
1.2
g/l
6.63
151
147
410
1236
11.04
151.39
4.7
2.8
630.3
954.9
ng/l
2.06
384
1028
69
17
46.48
115.64
2.6
1.2
8.6
9.0
ug/l
0.16
69
17
496
2681
13.25
78.49
14.8
9.0
3.7
4.0
e9/l
2.17
487
2358
444
2190
7.15
76.78
12.1
5.6
57.9
56.9
%
1.28
439
2043
64
40
18.05
76.50
1.2
1.2
—
—
—
0
0
64
40
18.05
76.50
1.2
1.2
—
—
—
0
0
445
2209
7.14
76.07
12.6
5.8
27.6
28.6
%
1.61
440
2046
64
41
17.60
75.54
1.3
1.2
—
—
—
0
0
64
41
17.60
75.54
1.3
1.2
—
—
—
0
0
64
41
17.60
75.54
1.2
1.2
—
—
—
0
0
151
311
6.38
74.04
3.8
2.7
97.6
136.8
ng/l
1.17
146
287
319
1358
4.36
61.83
2.5
2.1
103.0
213.1
u/l
1.55
309
1283
57
43
14.72
61.40
1.3
1.1
15.3
79.0
u/ml
—
13
6
37
19
20.85
48.00
1.1
1.1
—
—
—
0
0
516
3528
15.50
47.05
11.1
4.2
12.2
12.2
mm/h
0.04
509
3256
400
2277
4.03
45.29
5.8
3.7
0.0
0.0
estimate
0.00
116
431
399
2307
3.90
43.18
7.1
4.9
0.0
0.0
estimate
0.50
119
428
399
2326
3.85
42.19
5.8
3.7
0.0
0.0
estimate
0.80
121
417
253
1132
3.35
41.04
2.9
2.4
825.7
7550.3
umol/l
4.38
238
963
363
2088
3.32
37.15
3.0
2.2
82.0
78.8
nmol/l
1.36
337
1859
58
93
6.88
35.42
3.1
3.1
3.8
4.8
e9/l
2.31
58
93
58
97
6.59
34.00
3.2
3.5
57.4
60.8
%
1.04
58
97
372
2263
3.13
32.72
7.3
6.1
1.2
1.2
mmol/l
1.85
308
1907
55
95
6.34
31.19
1.7
1.9
116.9
130.9
g/l
1.96
15
67
347
2077
2.92
30.57
6.8
5.3
1.2
1.2
mmol/l
1.25
322
1883
244
1236
2.80
29.35
6.9
4.1
0.0
0.0
estimate
0.80
122
425
197
948
2.71
25.48
1.3
1.3
40.7
33.5
iu/ml
0.24
87
312
20
11
18.85
24.83
1.1
1.1
—
—
—
0
0
288
1774
2.36
20.75
6.4
3.8
—
—
—
0
0
36
64
5.96
19.71
1.4
1.2
6.9
1.5
u/ml
0.53
14
17
143
660
2.59
19.38
3.5
2.1
11.1
13.0
umol/l
2.24
136
610
126
553
2.67
18.86
3.5
2.2
20.2
22.2
%
0.74
110
472
200
1088
2.34
18.81
3.9
2.1
3.1
3.1
mg/l
0.01
183
916
102
406
2.87
18.38
2.9
2.1
0.2
0.2
g/l
1.90
94
389
293
1916
2.18
17.08
6.0
4.1
35.5
35.9
g/l
0.56
278
1787
206
1183
2.21
16.59
3.4
2.8
0.2
0.4
e6/l
1.19
178
871
34
69
5.20
16.15
1.3
1.1
3.9
7.3
u/ml
0.39
15
26
127
600
2.47
16.08
3.5
2.1
2.4
2.4
g/l
0.41
121
558
166
912
2.19
14.61
1.3
1.3
19.4
11.2
u/ml
0.53
67
332
30
62
5.07
13.96
1.7
1.5
—
—
—
0
0
128
644
2.30
13.87
2.3
1.8
—
—
—
0
0
85
356
2.65
13.69
2.1
2.7
65.1
67.1
g/l
1.39
79
326
522
4605
7.47
13.52
26.3
12.9
17.3
21.3
mg/l
2.26
446
3570
45
134
3.58
13.04
1.9
1.6
0.1
0.2
iu/ml
—
9
18
21
33
6.58
12.91
1.5
1.4
40.5
47.9
%
0.25
11
18
37
98
3.98
12.66
1.6
1.6
—
—
—
0
0
133
711
2.16
12.28
2.8
2.5
0.6
1.2
e6/l
3.55
101
380
45
143
3.34
11.80
1.5
1.3
277.6
313.9
ug/g
0.51
24
81
248
1675
1.90
11.69
4.4
3.3
24.3
50.9
ng/l
0.64
179
1115
37
104
3.75
11.66
1.6
1.6
—
—
—
0
0
25
53
4.90
11.29
1.8
1.5
—
—
—
0
0
25
53
4.90
11.29
1.8
1.6
—
—
—
0
0
180
1107
1.95
11.16
1.3
1.3
0.5
1.6
u/ml
1.82
41
293
30
75
4.18
11.09
1.7
1.6
—
—
—
0
0
40
123
3.43
11.04
2.7
2.5
—
—
—
0
0
326
2432
1.88
11.00
7.3
5.7
9.9
10.1
umol/l
0.07
307
2304
25
56
4.63
10.59
1.4
1.6
56.5
52.5
%
0.17
15
35
17
27
6.47
10.33
1.7
1.4
12.0
7.8
u/l
0.22
12
12
19
34
5.76
10.29
1.1
1.7
—
—
—
0
0
19
34
5.76
10.29
1.1
1.7
—
—
—
0
0
19
34
5.76
10.29
1.1
1.7
—
—
—
0
0
91
446
2.25
10.28
2.0
1.8
—
—
—
0
0
29
76
3.98
10.07
6.1
5.7
2574.7
193.1
iu/ml
—
10
10
71
316
2.44
9.99
2.0
1.5
—
—
—
0
0
17
28
6.24
9.98
1.9
1.8
26.6
11.0
%
—
5
13
28
72
4.05
9.98
1.6
1.6
—
—
—
0
0
46
166
2.94
9.76
2.0
2.1
1.5
1.6
g/l
0.50
39
143
90
450
2.20
9.66
2.1
1.8
—
—
—
0
0
100
526
2.11
9.43
5.4
4.4
1.0
1.0
mmol/l
0.38
93
482
15
23
6.68
9.40
1.5
1.2
1.1
1.1
ratio
—
5
8
18
34
5.44
9.22
1.2
1.2
—
—
—
0
0
35
111
3.30
9.22
1.5
1.4
—
—
—
0
0
79
383
2.25
9.12
4.0
3.5
1.2
1.2
mmol/l
0.77
72
333
30
87
3.59
9.05
1.3
1.3
—
—
—
0
0
16
28
5.86
8.85
1.4
1.2
—
—
—
0
0
88
453
2.13
8.74
9.5
7.5
0.5
1.5
mmol/l
1.95
71
365
19
40
4.89
8.65
1.8
1.5
—
—
—
0
0
56
245
2.44
8.16
8.1
8.7
23.9
25.1
mmol/l
1.47
50
235
276
2068
1.69
8.15
4.1
2.7
79.0
98.5
ug/l
2.03
256
1913
15
27
5.69
8.06
1.9
1.8
—
—
—
0
0
11
14
8.00
8.01
1.0
2.0
—
—
—
0
0
11
14
8.00
8.01
1.0
2.0
—
—
—
0
0
11
14
8.00
8.01
1.0
2.0
—
—
—
0
0
42
161
2.75
7.99
2.3
1.8
3.0
3.1
g/l
0.31
36
132
43
172
2.63
7.54
2.3
1.8
—
—
—
0
0
43
172
2.63
7.54
2.3
1.8
3.3
3.8
g/l
2.61
35
130
43
172
2.63
7.54
2.3
1.8
7.0
7.5
g/l
0.97
36
138
373
3064
1.72
7.52
5.6
4.5
18.5
1010.7
e6/l
—
6
45
28
88
3.30
7.50
1.5
1.2
—
—
—
0
0
33
116
2.97
7.35
1.2
1.2
—
—
—
0
0
201
1426
1.66
7.02
3.3
2.3
60.5
55.2
u/l
1.08
180
1310
16
35
4.68
6.97
1.3
1.2
—
—
—
0
0
151
998
1.72
6.86
7.9
4.2
1.0
1.0
kg/l
0.59
19
130
206
1480
1.64
6.80
4.5
2.9
31.6
29.3
u/l
0.73
198
1403
22
63
3.60
6.78
1.0
1.1
—
—
—
0
0
127
805
1.76
6.68
1.7
1.7
1209.8
1242.8
nmol/l
0.15
99
586
16
37
4.43
6.53
1.3
1.7
—
—
—
0
0
222
1642
1.60
6.42
2.6
3.4
2.3
2.4
mmol/l
1.59
192
1431
28
97
2.99
6.41
1.1
1.8
—
—
—
0
0
12
22
5.56
6.31
1.0
1.7
—
—
—
0
0
12
22
5.56
6.31
1.0
1.7
—
—
—
0
0
12
22
5.56
6.31
1.0
1.7
—
—
—
0
0
12
22
5.56
6.31
1.0
1.7
—
—
—
0
0
156
1071
1.65
6.04
1.6
1.5
23.9
22.1
nmol/l
0.37
133
895
110
702
1.71
5.57
3.6
3.1
0.8
0.8
mmol/l
0.16
101
659
123
812
1.67
5.49
4.3
3.5
80.0
249.0
ng/l
1.23
95
599
434
3841
1.70
5.35
29.4
16.1
14.3
13.6
%
15.88
434
3769
16
44
3.72
5.24
1.3
1.6
—
—
—
0
0
240
1870
1.52
5.19
2.0
1.9
95.4
98.5
pmol/l
0.37
115
872
21
70
3.08
5.15
1.6
1.4
—
—
—
0
0
309
2552
1.50
4.96
6.6
4.3
6.4
6.6
mmol/l
0.86
299
2383
81
491
1.77
4.89
2.8
2.4
6.1
6.3
umol/l
0.05
74
417
137
954
1.59
4.88
1.6
1.7
498.3
31305903.9
pmol/l
1.32
111
789
43
213
2.11
4.72
12.2
7.5
23.7
24.4
mmol/l
0.81
33
199
10
21
4.83
4.55
1.1
1.5
—
—
—
0
0
337
2863
1.48
4.50
2.9
3.0
—
—
—
0
0
27
112
2.49
4.46
1.3
1.4
—
—
—
0
0
9
12
7.61
4.37
2.3
1.7
—
—
—
0
0
8
10
8.10
4.07
1.8
1.0
—
—
—
0
0
11
28
3.99
3.99
1.7
2.8
—
—
—
0
0
17
60
2.89
3.82
1.5
1.3
127.9
98.7
u/ml
—
5
12
27
122
2.28
3.73
1.3
1.2
—
—
—
0
0
26
116
2.31
3.70
1.5
1.4
—
—
—
0
0
41
220
1.94
3.66
5.1
3.2
1.9
1.8
mmol/l
0.04
30
169
423
3832
1.50
3.55
4.6
4.4
15.3
14.8
pmol/l
4.56
394
3505
10
26
3.90
3.53
1.8
2.0
1617.2
775.9
e6/l
—
5
10
9
18
5.07
3.38
1.8
1.1
23.3
32.9
umol/l
—
9
18
71
462
1.62
3.31
3.9
3.2
—
—
—
0
0
6
7
8.65
3.27
1.5
1.4
—
—
—
0
0
16
60
2.72
3.25
2.1
1.5
—
—
—
0
0
7
11
6.43
3.19
1.0
1.1
109.0
105.3
%
—
7
11
7
11
6.43
3.19
1.0
1.1
—
—
—
0
0
32
166
1.99
3.16
2.4
1.8
—
—
—
0
0
61
388
1.65
3.11
3.0
2.5
68.0
67.7
ml/min/173m2
0.01
28
163
15
56
2.73
3.08
1.1
1.1
—
—
—
0
0
474
4438
1.61
3.05
20.4
12.1
80.8
81.2
ml/min/173m2
0.16
438
3626
89
623
1.51
3.02
2.3
1.7
30.0
29.3
s
0.68
89
604
11
35
3.19
2.94
2.6
1.5
—
—
—
0
0
472
4423
1.59
2.93
5.6
5.2
2.1
2.1
mu/l
0.05
439
4056
137
1056
1.40
2.81
2.0
1.6
1.8
1.0
mg/l
0.71
116
825
117
877
1.43
2.81
2.2
2.8
2.5
2.5
mmol/l
0.17
104
776
25
125
2.05
2.75
6.0
3.7
3.8
3.8
mmol/l
0.06
25
116
39
227
1.77
2.75
1.8
1.6
—
—
—
0
0
6
10
6.05
2.70
1.7
1.3
1.5
3.1
mmol/l
—
6
10
6
10
6.05
2.70
1.3
1.2
—
—
—
0
0
29
157
1.90
2.57
2.1
1.7
—
—
—
0
0
18
81
2.26
2.56
3.7
2.2
14.1
16.2
%
—
10
42
55
359
1.59
2.56
4.3
3.0
1.4
2.2
mmol/l
1.01
44
288
19
88
2.20
2.54
1.6
1.6
—
—
—
0
0
52
336
1.61
2.52
2.5
2.3
24.1
5.2
ug/l
0.56
41
296
9
26
3.50
2.49
2.7
1.4
—
—
—
0
0
9
26
3.50
2.49
2.7
1.4
—
—
—
0
0
9
27
3.37
2.40
2.7
1.4
—
—
—
0
0
31
176
1.81
2.39
1.8
1.6
—
—
—
0
0
40
247
1.67
2.32
1.5
1.4
—
—
—
0
0
18
88
2.08
2.13
1.4
1.4
—
—
—
0
0
18
88
2.08
2.13
1.4
1.4
—
—
—
0
0
12
49
2.48
2.11
2.5
1.5
—
—
—
0
0
5
10
5.04
2.07
2.4
1.8
—
—
—
0
0
7
20
3.53
2.06
1.3
1.3
—
—
—
0
0
34
210
1.66
2.00
1.4
2.4
41.7
41.2
u/l
0.06
34
188
30
180
1.71
1.96
5.0
2.7
23.2
24.5
mmol/l
1.55
24
162
6
16
3.78
1.94
1.2
1.9
—
—
—
0
0
6
16
3.78
1.94
1.2
1.9
—
—
—
0
0
9
33
2.76
1.94
2.0
2.3
—
—
—
0
0
494
4747
1.56
1.92
21.9
14.6
139.3
139.8
mmol/l
2.72
487
4620
14
66
2.15
1.83
1.4
1.4
—
—
—
0
0
14
66
2.15
1.83
1.4
1.4
—
—
—
0
0
54
380
1.47
1.83
4.0
3.0
79.1
73.9
ng/l
0.21
45
340
110
1357
0.76
1.78
4.2
3.8
25.0
7.3
mg/mmol
0.78
68
763
14
67
2.12
1.77
1.4
1.4
—
—
—
0
0
14
67
2.12
1.77
1.4
1.4
—
—
—
0
0
14
67
2.12
1.77
1.4
1.4
—
—
—
0
0
6
18
3.36
1.75
4.2
5.7
—
—
—
0
0
29
179
1.66
1.73
2.1
2.6
28.1
915.4
u/ml
0.62
22
155
27
426
0.61
1.70
1.5
1.7
—
—
—
0
0
12
55
2.21
1.68
1.2
1.1
—
—
—
0
0
75
574
1.36
1.61
9.4
6.3
—
—
—
0
0
493
4759
1.48
1.60
22.0
14.7
3.9
3.9
mmol/l
0.08
485
4625
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
101
1.81
1.50
2.7
2.4
0.3
0.4
u/ml
—
8
58
6
22
2.75
1.44
1.2
1.1
—
—
—
0
0
130
1093
1.25
1.39
3.2
2.2
—
—
—
0
0
13
67
1.96
1.39
1.5
1.4
—
—
—
0
0
81
650
1.29
1.27
3.0
2.7
3.1
3.7
e6/l
0.17
49
324
21
132
1.62
1.22
1.4
2.6
11.7
11.7
mg/l
0.00
21
123
13
72
1.83
1.16
1.5
1.2
—
—
—
0
0
27
385
0.69
1.11
1.6
1.8
—
—
—
0
0
236
2145
1.18
1.11
5.5
3.9
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
31
2.27
1.10
1.0
1.1
—
—
—
0
0
5
21
2.39
1.09
1.0
1.0
—
—
—
0
0
30
212
1.44
1.06
1.8
2.5
0.2
0.1
e6/l
0.27
30
204
8
42
1.92
0.89
1.1
1.3
—
—
—
0
0
6
33
1.83
0.79
1.3
1.3
12.2
17.7
ug/l
—
6
33
26
348
0.73
0.79
1.5
1.7
—
—
—
0
0
0
27
0.00
0.77
0.0
1.3
—
—
—
0
0
17
117
1.47
0.72
1.2
2.1
3984.3
4706.4
u/l
—
5
43
7
42
1.68
0.68
1.1
1.2
—
—
—
0
0
7
42
1.68
0.68
1.1
1.2
—
—
—
0
0
5
27
1.86
0.68
4.8
3.2
—
—
—
0
0
5
29
1.73
0.64
1.6
1.8
—
—
—
0
0
424
4348
0.88
0.56
4.7
5.5
38.2
39.3
mmol/mol
0.74
390
4034
20
151
1.34
0.54
1.3
1.6
—
—
—
0
0
26
205
1.28
0.53
1.4
1.4
—
—
—
0
0
39
466
0.82
0.52
1.3
1.6
1.6
1.4
%
0.87
33
412
25
199
1.27
0.49
3.4
2.2
1.0
1.1
%
0.65
25
199
38
320
1.20
0.46
2.1
3.1
4.1
4.5
pmol/l
1.83
29
281
122
1322
0.90
0.45
1.6
1.7
1.2
1.4
mmol/l
1.37
95
1111
9
129
0.69
0.43
1.3
1.6
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
68
607
1.14
0.42
4.0
4.4
34.2
33.2
%
0.30
50
385
26
213
1.23
0.41
1.7
1.4
—
—
—
0
0
5
33
1.52
0.41
1.0
1.3
2.4
1.9
mmol/l
—
5
33
0
16
0.00
0.41
0.0
1.0
—
104.1
—
0
8
0
16
0.00
0.41
0.0
1.0
—
110.6
—
0
8
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
57
505
1.14
0.39
26.4
20.7
1.0
1.2
inr
—
9
69
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
12
90
1.34
0.36
1.8
1.8
—
—
—
0
0
5
76
0.65
0.36
1.2
1.4
—
—
—
0
0
5
76
0.65
0.36
1.2
1.4
—
—
—
0
0
5
76
0.65
0.36
1.2
1.4
—
—
—
0
0
113
1053
1.09
0.34
1.4
1.4
—
—
—
0
0
91
850
1.09
0.27
1.4
1.5
—
—
—
0
0
314
3067
1.06
0.24
4.3
2.9
58.8
43.0
u/l
2.56
291
2860
34
378
0.89
0.22
1.1
1.2
62.1
162.2
iu/ml
—
9
166
453
4479
1.08
0.22
3.8
4.0
1.1
1.3
mmol/l
5.22
421
4089
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
22.7
—
0
12
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
2.5
—
2.5
—
0
5
6
52
1.16
0.19
1.0
1.1
—
—
—
0
0
6
52
1.16
0.19
2.8
3.6
—
—
—
0
0
15
129
1.17
0.17
1.5
1.6
364.4
289.7
mu/l
—
10
119
18
158
1.14
0.16
1.6
1.1
—
—
—
0
0
420
4160
1.05
0.14
27.1
14.2
38.9
39.6
%
1.04
256
3007
16
142
1.13
0.13
1.3
1.3
235.8
246.7
miu/ml
—
6
68
52
493
1.06
0.12
2.3
3.8
5.1
8.8
ug/l
1.19
39
401
472
4748
0.95
0.12
4.6
5.0
2.6
2.9
mmol/l
7.94
442
4365
28
261
1.08
0.10
1.7
1.4
—
—
—
0
0
5
44
1.14
0.10
1.0
1.0
—
—
—
0
0
23
247
0.93
0.09
1.6
1.3
34.3
33.2
iu/l
0.04
17
214
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
16
146
1.10
0.08
1.4
1.2
—
—
—
0
0
11
98
1.13
0.07
7.0
1.6
0.8
0.8
nmol/l
0.00
11
79
34
323
1.06
0.07
3.7
4.0
18.5
22.0
%
0.69
15
145
43
413
1.04
0.07
5.0
4.5
2.7
2.8
ug/l
0.04
37
368
17
158
1.08
0.06
1.6
1.1
—
—
—
0
0
466
4643
1.03
0.05
4.3
4.4
1.6
1.6
mmol/l
1.87
434
4268
12
113
1.06
0.02
1.3
1.1
—
—
—
0
0
21
203
1.04
0.01
2.3
1.7
—
—
—
0
0
16
155
1.03
0.00
1.8
1.7
—
—
—
0
0
12
116
1.04
0.00
1.8
1.3
—
—
—
0
0
25
247
1.01
0.00
2.3
2.7
0.5
0.8
ug/l
1.81
14
155
25
252
0.99
0.00
1.0
1.1
—
—
—
0
0
466
4659
1.00
0.00
4.3
4.5
4.6
4.9
mmol/l
5.16
436
4302
457
4569
1.00
0.00
4.1
4.5
5.5
5.9
mmol/l
13.63
423
4173
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
67
0.89
0.00
1.3
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
113.4
—
0
9
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
0.00
1.0
1.2
50.4
16.9
u/l
—
7
63
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
0.00
1.1
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
65.7
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint CREST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CREST | 2.418 [2.09, 2.8] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 370 out of 1714 females with CREST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CREST | 2.657 [1.86, 3.8] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 263 males with CREST died.
Mortality risk
Mortality risk for people of age
years, who have CREST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.263% | 0.492% |
| 5 | 1.279% | 3.229% |
| 10 | 3.077% | 7.7% |
| 15 | 6.036% | 14.045% |
| 20 | 10.835% | 23.099% |
Relationships between endpoints
↥Index endpoint: CREST – CR(E)ST syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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