No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
567 |
4. Check minimum number of eventsNone |
567 |
5. Include endpointsNone |
567 |
6. Filter based on genotype QC (FinnGen only) |
546 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M34
- Name in latin
- Syndroma CREST
Similar endpoints
↥List of similar endpoints to
CR(E)ST syndrome
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis, icd10
- Systemic sclerosis
- Systemic sclerosis (FG)
- Systemic connective tissue disorders
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2272 | 1946 | 313 |
| Only index persons | 2112 | 1834 | 278 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.01 |
| Only index persons | 0.06 | 0.07 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.34 | 58.28 | 59.14 |
| Only index persons | 57.94 | 57.80 | 58.89 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 546 | 477 | 69 |
| Unadjusted period prevalence (%) | 0.15 | 0.17 | 0.03 |
| Median age at first event (years) | 57.81 | 57.75 | 58.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 567
- Matched controls
- 5670
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
307.7
567
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
28.5
307.7
385
392
C08CA05
ATC
nifedipine; systemic
38.8
307.7
288
147
P01BA02
ATC
hydroxychloroquine; oral
23.9
307.7
334
321
I73.0
ICD-10 Finland
Raynaud syndrome
76.1
307.7
182
35
XX9XE
NOMESCO Finland
Other ultrasound examination
83.2
240.3
129
20
L04AX03
ATC
methotrexate; systemic
13.3
207.4
266
354
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
383.3
170.9
164
6
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
39.6
165.6
104
32
L04AA06
ATC
mycophenolic acid; systemic
34.3
155.6
102
36
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
10.8
139.8
183
240
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
13.6
123.7
128
119
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
8.3
113.7
187
317
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
10.9
85.7
100
109
XPX04
NOMESCO Finland
Angioscopy
228.9
78.4
79
*
M34.0
ICD-10 Finland
Progressive systemic sclerosis
433.6
77.8
76
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
8.1
74.6
113
170
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
4.7
74.4
322
1233
L88
ICPC
Rheumatoid/seropositive arthritis
9.0
73.7
100
132
L04AX01
ATC
azathioprine; systemic
10.1
72.6
89
103
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.6
68.3
252
845
G04BE03
ATC
sildenafil; oral
98.1
63.5
69
8
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
667.1
62.0
60
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
10.7
60.8
70
74
C08CA02
ATC
felodipine; oral
6.0
59.3
122
249
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
11.0
58.0
65
66
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
+∞
53.0
50
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.9
52.2
376
1911
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.8
50.4
135
344
R4120
NOMESCO Finland
Occupational therapy
5.8
49.2
101
204
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
10.6
47.3
54
56
XG410
NOMESCO Finland
Flow-volume spirometry
8.1
47.2
67
92
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
5.1
45.2
108
249
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
10.3
43.9
51
54
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.4
40.9
121
330
NH3EA
NOMESCO Finland
Feet X-ray examination with load
9.2
40.6
51
60
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
15.3
40.3
36
25
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
391.8
37.5
37
*
A05AA02
ATC
ursodeoxycholic acid; oral
12.3
37.3
38
33
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.5
36.1
157
557
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
12.3
35.5
36
31
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
12.9
34.4
34
28
GD1AD
NOMESCO Finland
Thorax CT examination
5.4
34.3
73
151
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
8.5
33.7
45
57
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
8.3
33.6
46
60
L01BA01
ATC
methotrexate; systemic
6.4
33.3
58
99
M35.1
ICD-10 Finland
Other overlap syndromes
41.7
31.6
39
10
H02AB06
ATC
prednisolone; systemic
2.7
29.2
349
2098
C08CA01
ATC
amlodipine; oral
2.7
28.9
284
1548
M34
ICD-10 Finland
Systemic sclerosis
295.4
28.0
28
*
L04AD01
ATC
ciclosporin; systemic
9.6
26.7
32
35
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
26.2
290
1653
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.7
25.4
91
280
K74.3
ICD-10 Finland
Primary biliary cirrhosis
31.7
25.3
33
11
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
27.7
25.2
34
13
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.7
24.8
87
264
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.2
24.2
70
185
C02KX01
ATC
bosentan; oral
+∞
23.1
22
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
6.4
22.8
39
65
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
65.2
22.0
25
*
C02KX04
ATC
macitentan; oral
+∞
21.0
20
*
WZA10
NOMESCO Finland
Extensive medical or dental certificate
9.0
20.8
26
30
TGC00
NOMESCO Finland
Bronchial lavation
6.5
20.4
34
55
R06.0
ICD-10 Finland
Dyspnoea
2.4
20.1
198
1042
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
19.4
175
883
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
19.1
324
2122
RT172, ,
NOMESCO Finland
103.5
18.7
20
*
RT160, ,
NOMESCO Finland
196.2
18.6
19
*
E0000UV, ,
ATC
2.2
18.1
291
1854
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
7.0
18.0
28
42
M01CC01
ATC
penicillamine; oral
98.2
17.7
19
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.0
17.3
82
298
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.2
17.2
73
248
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.0
16.9
81
296
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
4.0
16.8
50
134
RT274, ,
NOMESCO Finland
49.0
16.1
19
*
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
15.7
15
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
15.3
154
804
J01FF01
ATC
clindamycin; systemic
2.1
15.2
195
1121
R4190
NOMESCO Finland
Nutritional therapy
4.6
14.9
36
82
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.0
14.5
69
250
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
14.4
93
397
R15
ICD-10 Finland
Faecal incontinence
4.1
14.0
40
104
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.6
14.0
34
78
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.1
14.0
62
216
L04AA01
ATC
[U] ciclosporin
11.8
13.9
25
22
A02BC02
ATC
pantoprazole; systemic
2.2
13.9
427
3323
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.3
13.7
55
180
SBA10
NOMESCO Finland
Measurement of salivary flow rate
10.4
13.6
26
26
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
3.9
13.3
40
108
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
13.2
265
1765
D06BX01
ATC
metronidazole; topical
2.4
12.9
96
437
S09
ICPC
Infected finger/toe
4.2
12.8
35
88
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
15.9
12.7
20
13
UJF30
NOMESCO Finland
Ileoscopy through colon
2.5
12.6
84
363
L95
ICPC
Osteoporosis
3.6
12.5
42
123
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
27.4
12.1
16
6
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.4
12.0
45
141
H04.10
ICD-10 Finland
Dry eye syndrome
2.3
11.7
99
476
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
14.0
11.5
19
14
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
11.5
11
*
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
122.4
11.5
12
*
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
122.4
11.5
12
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
11.4
73
309
RT271, ,
NOMESCO Finland
35.8
11.3
14
*
UJF32
NOMESCO Finland
Coloscopy
1.9
11.1
173
1047
K22.7
ICD-10 Finland
Barrett oesophagus
10.3
11.1
21
21
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
4.8
11.0
25
54
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
11.0
188
1173
RT310, ,
NOMESCO Finland
44.2
11.0
13
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.6
10.9
21
39
R13
ICD-10 Finland
Dysphagia
2.7
10.8
60
236
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
2.9
10.8
52
190
K22.1
ICD-10 Finland
Ulcer of oesophagus
8.2
10.7
23
29
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
8.2
10.7
23
29
I27.0
ICD-10 Finland
Primary pulmonary hypertension
61.2
10.7
12
*
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
61.2
10.7
12
*
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
61.2
10.7
12
*
RT231, ,
NOMESCO Finland
61.2
10.7
12
*
C08DB01
ATC
diltiazem; oral
3.4
10.3
38
118
NDQ20
NOMESCO Finland
Amputation of finger
40.8
10.0
12
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.5
10.0
64
271
GD2SN
NOMESCO Finland
Lung ventilation SPECT
17.1
9.9
15
9
ZX120
NOMESCO Finland
Intravenous
2.4
9.8
71
318
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.4
9.7
74
339
TPH04
NOMESCO Finland
Cathetrisation of vein
2.0
9.7
135
783
RT272, ,
NOMESCO Finland
15.4
9.6
15
10
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
15.4
9.6
15
10
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
9.5
238
1651
A02BC01
ATC
omeprazole; systemic
1.8
9.5
175
1110
M05BX04
ATC
denosumab; parenteral
2.8
9.5
49
186
K62.3
ICD-10 Finland
Rectal prolapse
7.1
9.4
22
32
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
22.1
9.4
13
6
H02AB07
ATC
prednisone; oral
2.1
9.3
97
505
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.1
9.1
25
63
D64.9
ICD-10 Finland
Anaemia, unspecified
2.4
9.1
63
276
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
9.1
36
117
S97
ICPC
Chronic ulcer skin
2.8
9.0
45
168
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
4.0
9.0
25
64
E000001, ,
ATC
1.9
8.9
130
764
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
4.1
8.9
24
60
C02DE02, ,
ATC
10.9
8.8
16
15
L99
ICPC
Musculoskeletal disease other
4.4
8.7
22
52
A02BC05
ATC
esomeprazole; systemic
1.7
8.7
263
1910
J01DB01
ATC
cefalexin; oral
2.0
8.7
481
4150
B80
ICPC
Iron deficiency anaemia
4.7
8.7
20
44
NHQ40
NOMESCO Finland
Amputation of toe
8.4
8.6
18
22
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
9.2
8.6
17
19
A10BA02
ATC
metformin; oral
0.4
8.5
44
999
K76.9
ICD-10 Finland
Liver disease, unspecified
5.0
8.4
18
37
B01AC27
ATC
selexipag; oral
+∞
8.4
8
*
RJ512, ,
NOMESCO Finland
+∞
8.4
8
*
383
Kela drug reimbursment
Selexipag
+∞
8.4
8
*
SPAT1263
SPAT
Sampling
1.7
8.3
245
1763
WZC30
NOMESCO Finland
Teaching
2.0
8.3
101
557
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.2
8.2
32
103
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.1
8.2
85
442
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.6
8.1
49
201
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.1
8.0
76
381
L30.9
ICD-10 Finland
Dermatitis, unspecified
1.9
8.0
125
748
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.0
7.9
22
56
J01AA04
ATC
lymecycline; systemic
2.1
7.9
86
454
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
7.9
7.9
17
22
NA1BA
NOMESCO Finland
Cervical spine extensive X-ray examination without contrast
8.6
7.9
16
19
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
7.8
79
407
GD1UN
NOMESCO Finland
Lung circulation SPECT
15.3
7.7
12
8
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.1
7.7
79
408
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
3.2
7.7
30
97
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
7.6
122
734
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.4
7.6
27
82
C03CA01
ATC
furosemide; systemic
1.7
7.5
152
983
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
2.7
7.5
39
149
I78.8
ICD-10 Finland
Other diseases of capillaries
81.1
7.4
8
*
NDQ48
NOMESCO Finland
Revision or amputation or exarticulation of finger
81.1
7.4
8
*
PHD76
NOMESCO Finland
Resection of long saphenous vein
2.7
7.4
39
150
R50.9
ICD-10 Finland
Fever, unspecified
2.0
7.3
87
474
Z3226
NOMESCO Finland
Physiotherapist
1.8
7.3
116
696
R76.0
ICD-10 Finland
Raised antibody titre
16.0
7.3
11
7
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
7.1
111
662
M05BA04
ATC
alendronic acid; oral
2.2
7.1
64
315
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
7.1
231
1688
A02BC03
ATC
lansoprazole; oral
1.7
7.0
181
1244
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
3.0
7.0
31
108
SBA00
NOMESCO Finland
Microbiological examinations
3.4
6.9
24
72
EB1BI
NOMESCO Finland
Cone beam imaging of teeth and jaws (1–2 quarters)
6.2
6.8
17
28
K23.8*B37.8
ICD-10 Finland
Esophagitis caused by candidiasis
16.9
6.8
10
6
A06AC51
ATC
ispaghula, combinations; oral
2.7
6.8
37
145
S18
ICPC
Laceration/cut
1.6
6.7
261
1980
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
6.7
45
195
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
6.6
43
183
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
6.6
178
1234
JGC01
NOMESCO Finland
Laparoscopic rectopexy
6.3
6.5
16
26
G73.7
ICD-10 Finland
Myopathy in other diseases classified elsewhere
70.6
6.4
7
*
PB1BC
NOMESCO Finland
Extensive angiography of upper extremity with X-ray
70.6
6.4
7
*
A03FA02
ATC
cisapride; oral, rectal
2.3
6.4
51
238
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.3
6.4
50
232
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.3
6.4
24
76
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
6.4
73
393
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.7
6.3
33
126
PD4AD
NOMESCO Finland
CT of lower extremity arteries
11.2
6.3
11
10
NFQ20
NOMESCO Finland
Amputation of femur
11.2
6.3
11
10
B01AC04
ATC
clopidogrel; oral
1.9
6.3
79
438
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
6.3
89
514
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
6.3
6
*
S01XA18
ATC
ciclosporin; ophthalmic
7.1
6.2
14
20
SPAT1211
SPAT
Application of soft bandage
2.2
6.2
54
261
ADA20
NOMESCO Finland
Thoracal sympathectomy
27.0
6.2
8
*
RJ420, ,
NOMESCO Finland
12.7
6.1
10
8
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.4
6.1
43
191
J02AC01
ATC
fluconazole; systemic
1.5
6.1
271
2108
GX1K5
NOMESCO Finland
Diffusion capacity
10.2
6.1
11
11
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.0
244
1855
UJF92
NOMESCO Finland
Capsular endoscopy
4.0
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
259
113
41.35
307.65
1.5
1.3
17.15
11.91
u/ml
—
35
8
277
149
35.39
307.65
1.6
1.2
3.15
2.31
u/ml
0.41
73
16
276
151
34.67
307.65
1.6
1.2
5.43
6.73
u/ml
0.14
104
26
280
162
33.17
307.65
1.6
1.2
4.51
16.31
u/ml
—
18
10
222
122
29.26
294.19
1.6
1.2
26.97
43.99
u/ml
0.42
36
14
199
115
26.12
256.15
1.4
1.2
0.41
—
u/ml
—
8
0
217
178
19.13
233.22
2.2
1.7
—
—
—
0
0
197
200
14.56
183.43
1.7
1.3
7.85
1.05
u/ml
3.04
17
11
340
708
10.50
181.30
1.8
1.3
2075.14
481.71
titre
31.29
255
164
174
152
16.07
177.56
2.0
1.6
0.20
0.24
g/l
3.93
163
147
174
160
15.25
171.84
2.0
1.6
1.07
1.21
g/l
5.70
164
153
436
1299
11.20
163.41
4.6
2.8
615.04
956.13
ng/l
2.40
409
1076
71
18
44.95
118.11
2.5
1.2
8.54
9.14
ug/l
0.28
71
18
528
2536
16.73
105.91
12.4
5.9
0.19
0.18
e9/l
1.29
515
2226
524
2514
15.30
104.58
12.2
5.5
1.65
1.95
e9/l
6.62
512
2220
72
40
20.47
91.23
1.2
1.2
—
—
—
0
0
72
40
20.47
91.23
1.2
1.2
—
—
—
0
0
72
41
19.97
90.18
1.2
1.2
—
—
—
0
0
72
41
19.97
90.18
1.2
1.2
—
—
—
0
0
72
41
19.97
90.18
1.2
1.2
—
—
—
0
0
474
2334
7.28
82.44
11.8
5.5
57.80
56.88
%
1.11
469
2175
475
2356
7.26
81.51
12.3
5.8
27.62
28.63
%
1.52
470
2193
525
2857
12.31
81.34
14.6
8.9
3.72
4.00
e9/l
2.72
512
2503
156
336
6.03
72.50
3.8
2.6
98.74
140.47
ng/l
1.34
151
310
62
46
15.01
67.47
1.3
1.2
14.13
70.43
u/ml
—
15
7
341
1444
4.42
66.84
2.5
2.1
103.16
208.65
u/l
1.58
331
1357
151
369
5.21
60.06
3.4
2.9
9.75
10.19
g/l
0.50
140
340
41
22
20.01
52.23
1.0
1.1
—
—
—
0
0
550
3740
16.70
51.19
10.8
4.2
12.31
12.17
mm/h
0.09
543
3454
427
2432
4.06
48.36
5.7
3.7
0.00
0.00
estimate
0.50
125
481
427
2456
3.99
47.07
7.1
5.0
0.00
0.00
estimate
0.50
122
456
427
2477
3.93
45.97
5.7
3.7
0.00
0.01
estimate
0.80
123
443
269
1222
3.29
42.18
2.9
2.4
788.79
6514.43
umol/l
4.12
256
1058
387
2220
3.34
39.93
3.0
2.2
81.91
78.56
nmol/l
1.51
361
1979
59
100
6.47
34.09
3.0
3.1
3.80
4.67
e9/l
2.09
59
100
393
2408
3.06
33.55
7.2
6.3
1.21
1.22
mmol/l
1.72
331
2054
59
104
6.22
32.77
3.2
3.5
57.41
60.42
%
0.89
59
104
57
100
6.23
31.79
1.7
1.9
116.93
129.72
g/l
1.74
15
72
216
1002
2.87
30.59
1.3
1.3
41.52
33.47
iu/ml
0.30
99
343
364
2210
2.81
30.31
6.7
5.3
1.21
1.22
mmol/l
1.30
343
2015
253
1311
2.68
28.44
6.7
4.1
0.00
0.00
estimate
0.80
125
452
34
45
7.97
24.45
2.1
2.1
—
—
—
0
0
201
1016
2.52
22.76
1.6
1.5
2.14
2.27
g/l
0.42
129
597
39
67
6.18
22.10
1.4
1.1
6.67
1.44
u/ml
0.55
15
18
304
1885
2.32
21.28
6.2
3.9
—
—
—
0
0
150
703
2.54
19.54
3.5
2.2
11.10
13.10
umol/l
2.53
143
655
183
947
2.38
19.13
2.9
2.4
3.51
6.96
e6/l
2.91
175
856
131
584
2.62
18.87
3.4
2.2
20.15
22.35
%
0.91
114
498
37
71
5.51
18.68
1.3
1.1
3.65
7.27
u/ml
0.43
17
26
209
1161
2.27
18.38
3.9
2.1
3.12
3.15
mg/l
0.06
192
975
219
1256
2.21
17.67
3.4
2.8
0.20
0.41
e6/l
1.60
191
924
310
2049
2.13
17.22
5.8
4.2
35.65
35.89
g/l
0.32
296
1920
180
961
2.28
17.22
1.3
1.3
17.91
11.66
u/ml
0.42
73
353
134
636
2.45
16.73
3.4
2.2
2.35
2.40
g/l
0.49
128
591
104
437
2.69
16.72
3.0
2.1
0.20
0.22
g/l
1.94
96
418
91
377
2.68
14.97
2.1
2.7
65.31
67.09
g/l
1.15
85
344
556
4900
7.94
14.62
25.6
12.9
17.34
21.39
mg/l
2.49
477
3810
31
64
5.07
14.43
1.7
1.5
—
—
—
0
0
22
13
17.54
14.40
1.1
1.1
—
—
—
0
0
223
1372
2.03
14.29
3.2
2.9
21.51
48.30
e6/l
1.00
196
1031
144
752
2.23
14.18
2.7
2.5
0.62
1.21
e6/l
4.12
111
400
27
55
5.10
12.75
1.7
1.6
—
—
—
0
0
132
693
2.18
12.69
2.3
1.8
—
—
—
0
0
38
103
3.88
12.58
1.6
1.6
—
—
—
0
0
32
77
4.34
12.40
1.7
1.6
—
—
—
0
0
47
150
3.33
12.22
1.5
1.3
284.90
316.52
ug/g
0.44
25
83
21
35
6.19
12.20
1.5
1.4
40.49
46.11
%
0.18
11
19
26
54
5.00
12.01
1.8
1.5
—
—
—
0
0
46
147
3.32
11.94
1.8
1.6
0.11
0.18
iu/ml
—
9
19
347
2591
1.87
11.61
7.1
5.7
9.92
10.19
umol/l
0.18
327
2459
191
1183
1.93
11.50
1.4
1.3
0.48
1.78
u/ml
2.09
45
311
38
110
3.63
11.46
1.6
1.6
—
—
—
0
0
294
2096
1.84
11.30
13.0
11.7
1.14
1.17
inr
0.30
100
616
20
35
5.89
11.07
1.2
1.2
—
—
—
0
0
41
128
3.37
11.04
2.7
2.5
—
—
—
0
0
254
1775
1.78
10.07
4.4
3.4
24.15
49.65
ng/l
0.65
184
1176
25
59
4.39
9.93
1.4
1.6
56.47
53.38
%
0.13
15
37
74
337
2.38
9.85
2.0
1.5
—
—
—
0
0
114
620
2.05
9.79
1.7
2.0
151.22
113.18
ug/g
0.93
94
494
95
482
2.17
9.78
2.0
1.7
—
—
—
0
0
32
92
3.63
9.76
1.4
1.3
—
—
—
0
0
19
36
5.43
9.70
1.1
1.7
—
—
—
0
0
19
36
5.43
9.70
1.1
1.7
—
—
—
0
0
19
36
5.43
9.70
1.1
1.7
—
—
—
0
0
30
83
3.76
9.67
6.0
5.6
2574.70
166.92
iu/ml
—
10
12
20
40
5.15
9.63
1.5
1.5
—
—
—
0
0
28
76
3.82
9.27
1.6
1.6
—
—
—
0
0
47
179
2.77
9.02
2.0
2.0
1.51
1.61
g/l
0.33
40
155
93
485
2.10
8.89
2.1
1.8
—
—
—
0
0
103
559
2.03
8.84
5.3
4.7
1.02
1.04
mmol/l
0.36
96
513
27
74
3.78
8.82
1.2
1.6
—
—
—
0
0
27
74
3.78
8.82
1.2
1.6
—
—
—
0
0
82
409
2.17
8.78
3.9
3.5
1.23
1.23
mmol/l
0.70
75
357
294
2217
1.68
8.33
4.1
2.7
81.26
98.32
ug/l
1.72
274
2047
30
92
3.39
8.32
1.5
1.2
—
—
—
0
0
91
483
2.05
8.28
9.3
7.8
0.72
1.48
mmol/l
1.08
77
391
35
120
3.04
8.11
1.5
1.4
—
—
—
0
0
213
1512
1.65
7.38
3.2
2.3
60.39
59.89
u/l
0.04
192
1390
45
187
2.53
7.29
2.2
1.8
—
—
—
0
0
161
1066
1.71
7.23
7.6
4.1
1.01
1.02
kg/l
0.48
21
138
23
65
3.65
7.21
1.0
1.1
—
—
—
0
0
217
1558
1.64
7.13
4.4
2.9
31.53
29.20
u/l
0.79
209
1478
237
1741
1.62
7.09
2.7
3.4
2.35
2.36
mmol/l
1.68
208
1534
167
1128
1.68
6.93
1.6
1.5
23.97
22.13
nmol/l
0.43
144
945
392
3276
1.64
6.69
5.4
4.5
18.50
1233.27
e6/l
—
6
48
16
25
6.55
6.68
1.5
1.2
1.09
1.11
ratio
—
5
9
133
853
1.73
6.64
1.7
1.7
1199.97
1224.25
nmol/l
0.11
105
617
33
124
2.76
6.53
1.2
1.2
—
—
—
0
0
16
28
5.85
6.18
1.4
1.2
—
—
—
0
0
258
1979
1.56
6.18
2.0
1.9
95.41
98.24
pmol/l
0.34
125
926
16
39
4.19
6.12
1.3
1.2
—
—
—
0
0
90
527
1.84
6.08
9.2
6.0
104.04
103.93
mmol/l
0.08
90
527
16
29
5.64
6.03
1.9
1.8
—
—
—
0
0
28
105
2.75
5.58
1.1
1.7
—
—
—
0
0
130
865
1.65
5.58
4.1
3.5
83.78
263.02
ng/l
1.42
101
637
87
522
1.79
5.42
2.7
2.4
6.05
6.42
umol/l
0.08
79
444
115
749
1.67
5.34
3.5
3.2
0.82
0.81
mmol/l
0.26
106
706
363
3064
1.51
5.19
2.9
3.0
—
—
—
0
0
16
45
3.63
5.08
1.3
1.6
—
—
—
0
0
11
16
6.99
4.97
1.0
1.9
—
—
—
0
0
11
16
6.99
4.97
1.0
1.9
—
—
—
0
0
11
16
6.99
4.97
1.0
1.9
—
—
—
0
0
16
38
4.30
4.85
1.3
1.7
—
—
—
0
0
474
4272
1.67
4.85
28.5
15.6
14.88
14.93
%
0.09
474
4206
21
73
2.95
4.81
1.6
1.4
—
—
—
0
0
9
10
9.12
4.80
1.7
1.0
—
—
—
0
0
326
2716
1.47
4.79
6.4
4.4
6.37
6.61
mmol/l
1.12
315
2534
28
116
2.49
4.62
1.3
1.4
—
—
—
0
0
9
12
7.60
4.37
2.3
1.7
—
—
—
0
0
12
24
5.08
4.34
1.0
1.7
—
—
—
0
0
12
24
5.08
4.34
1.0
1.7
—
—
—
0
0
18
61
3.01
4.32
2.9
1.8
8.78
67.41
u/ml
0.47
18
61
164
1215
1.49
4.29
5.9
3.3
92.41
95.33
%
0.83
156
1178
48
257
1.95
4.27
5.0
3.3
5.19
5.13
kpa
0.18
48
250
142
1023
1.52
4.24
1.6
1.6
493.59
29231220.85
pmol/l
1.32
116
845
11
21
5.32
4.16
1.1
1.5
—
—
—
0
0
7
7
10.10
4.02
1.4
1.4
—
—
—
0
0
450
4068
1.51
3.88
4.7
4.4
15.27
14.75
pmol/l
4.35
421
3721
27
121
2.29
3.80
1.5
1.4
—
—
—
0
0
18
66
2.78
3.79
1.4
1.4
127.90
101.48
u/ml
—
5
14
28
128
2.25
3.76
1.3
1.2
—
—
—
0
0
15
50
3.05
3.71
1.3
1.6
—
—
—
0
0
15
50
3.05
3.71
1.3
1.6
—
—
—
0
0
16
58
2.81
3.45
1.1
1.1
—
—
—
0
0
506
4727
1.65
3.44
20.0
12.1
81.06
81.34
ml/min/173m2
0.11
468
3865
96
665
1.53
3.40
2.3
1.7
29.95
29.34
s
0.65
96
644
7
10
7.07
3.37
1.7
1.3
0.99
3.14
mmol/l
—
7
10
13
38
3.48
3.33
1.4
1.2
1069.14
1596.58
e6/l
—
7
26
147
1115
1.43
3.31
2.0
1.6
1.68
1.00
mg/l
0.70
125
874
43
243
1.83
3.29
4.9
3.2
1.92
1.89
mmol/l
0.01
31
190
21
90
2.38
3.28
1.6
1.6
—
—
—
0
0
9
19
4.80
3.25
1.8
1.1
23.33
32.79
umol/l
—
9
19
503
4707
1.61
3.22
5.7
5.2
2.09
2.13
mu/l
0.06
470
4321
7
11
6.43
3.19
1.0
1.1
109.00
105.27
%
—
7
11
33
176
1.93
3.02
2.4
1.8
—
—
—
0
0
11
31
3.60
3.00
1.6
2.5
—
—
—
0
0
16
63
2.58
2.98
2.1
1.6
—
—
—
0
0
124
931
1.42
2.93
2.3
2.8
2.45
2.46
mmol/l
0.29
111
823
10
27
3.75
2.89
2.5
1.4
—
—
—
0
0
10
27
3.75
2.89
2.5
1.4
—
—
—
0
0
59
381
1.61
2.84
4.1
3.1
1.05
2.23
mmol/l
1.66
50
316
11
33
3.38
2.82
1.3
1.3
4401.20
70065.88
e6/l
—
5
17
10
28
3.62
2.79
2.5
1.4
—
—
—
0
0
63
415
1.58
2.79
2.9
2.6
68.17
67.58
ml/min/173m2
0.04
29
173
39
227
1.77
2.74
1.3
2.4
42.36
40.98
u/l
0.16
39
202
6
10
6.05
2.70
1.3
1.2
—
—
—
0
0
10
29
3.49
2.70
1.8
1.9
1139.40
699.72
e6/l
—
10
29
44
267
1.70
2.69
1.5
1.4
—
—
—
0
0
33
184
1.84
2.67
1.8
1.6
—
—
—
0
0
72
497
1.51
2.60
3.8
3.2
—
—
—
0
0
41
247
1.71
2.58
1.8
1.6
—
—
—
0
0
30
166
1.85
2.50
2.0
1.7
—
—
—
0
0
11
38
2.93
2.42
2.6
1.5
—
—
—
0
0
13
52
2.54
2.37
2.4
1.5
—
—
—
0
0
54
358
1.56
2.35
2.5
2.3
23.37
5.05
ug/l
0.57
43
314
17
78
2.22
2.33
1.9
2.9
0.59
1.20
%
1.20
17
70
8
24
3.37
2.18
1.3
1.2
—
—
—
0
0
556
5420
2.33
2.15
38.9
19.5
39.49
39.77
%
0.76
527
5106
18
88
2.08
2.13
3.7
2.3
14.11
15.98
%
—
10
46
58
403
1.49
2.06
3.8
3.2
75.62
76.62
ng/l
0.04
49
359
526
5055
1.56
2.04
21.4
14.6
139.33
139.75
mmol/l
2.77
519
4919
54
372
1.50
2.00
2.4
2.5
18.36
27.81
au/ml
—
5
24
6
17
3.56
1.84
1.2
1.9
—
—
—
0
0
6
17
3.56
1.84
1.2
1.9
—
—
—
0
0
118
1449
0.77
1.82
3.9
3.6
23.83
7.32
mg/mmol
0.76
72
815
5
12
4.19
1.82
2.4
1.7
—
—
—
0
0
18
95
1.92
1.77
1.4
1.3
—
—
—
0
0
18
95
1.92
1.77
1.4
1.3
—
—
—
0
0
90
697
1.35
1.76
2.9
2.7
3.89
3.75
e6/l
0.03
57
349
13
61
2.16
1.72
1.2
1.1
—
—
—
0
0
14
68
2.09
1.71
1.4
1.4
—
—
—
0
0
14
68
2.09
1.71
1.4
1.4
—
—
—
0
0
14
68
2.09
1.71
1.4
1.4
—
—
—
0
0
14
68
2.09
1.71
1.4
1.4
—
—
—
0
0
525
5069
1.48
1.68
21.6
14.7
3.94
3.94
mmol/l
0.03
517
4926
6
19
3.18
1.66
4.2
5.5
—
—
—
0
0
14
69
2.06
1.66
1.4
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
113
1.80
1.62
2.5
2.3
0.35
0.39
u/ml
—
9
61
24
144
1.70
1.60
1.3
2.5
11.71
11.95
mg/l
0.06
24
134
30
450
0.65
1.52
1.6
1.7
—
—
—
0
0
29
187
1.58
1.48
2.1
2.7
27.61
891.16
u/ml
0.62
23
161
9
38
2.39
1.46
2.0
2.2
—
—
—
0
0
10
46
2.19
1.40
1.7
2.6
62.40
51.79
%
—
10
41
78
617
1.31
1.35
9.3
6.3
—
—
—
0
0
13
68
1.93
1.34
1.5
1.4
—
—
—
0
0
137
1163
1.23
1.33
3.2
2.2
—
—
—
0
0
123
1450
0.81
1.32
3.2
3.0
6.40
6.79
mmol/l
0.45
103
1214
6
24
2.52
1.30
1.2
1.1
—
—
—
0
0
33
232
1.45
1.18
1.8
2.4
0.22
0.14
e6/l
0.26
33
222
252
2292
1.18
1.16
3.4
2.4
—
—
—
0
0
31
429
0.71
1.09
1.7
1.8
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
32
2.20
1.08
1.0
1.1
—
—
—
0
0
5
22
2.28
1.03
1.0
1.0
—
—
—
0
0
9
48
1.89
1.01
1.1
1.3
—
—
—
0
0
13
78
1.68
0.92
1.5
1.3
—
—
—
0
0
8
43
1.87
0.87
1.1
1.2
—
—
—
0
0
8
43
1.87
0.87
1.1
1.2
—
—
—
0
0
19
133
1.44
0.74
1.2
2.1
3984.30
4185.24
u/l
—
5
53
30
389
0.76
0.74
1.6
1.7
—
—
—
0
0
448
4607
0.87
0.67
4.7
5.4
38.04
39.36
mmol/mol
1.00
414
4271
5
28
1.79
0.66
1.4
3.9
842.20
776.93
u/ml
—
5
28
5
29
1.73
0.64
4.8
3.2
—
—
—
0
0
5
30
1.67
0.61
1.6
1.8
—
—
—
0
0
27
210
1.30
0.60
3.3
2.2
0.98
1.18
%
1.10
27
210
10
150
0.66
0.59
1.3
1.6
—
—
—
0
0
123
1118
1.13
0.54
1.4
1.4
—
—
—
0
0
6
38
1.58
0.54
1.3
1.4
12.23
17.53
ug/l
—
6
38
338
3247
1.10
0.52
4.2
2.9
57.68
43.06
u/l
2.43
315
3031
14
100
1.41
0.52
2.0
1.7
—
—
—
0
0
101
911
1.13
0.51
1.6
1.5
—
—
—
0
0
28
229
1.23
0.44
1.8
1.4
—
—
—
0
0
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
17
0.00
0.40
0.0
1.0
—
110.11
—
0
9
0
17
0.00
0.40
0.0
1.0
—
100.00
—
0
9
20
159
1.27
0.40
1.3
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
71
638
1.13
0.40
4.0
4.4
33.85
33.27
%
0.17
54
407
43
494
0.86
0.39
1.4
1.6
1.58
1.37
%
0.86
37
439
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
27
224
1.22
0.39
1.4
1.4
—
—
—
0
0
5
36
1.39
0.38
1.0
1.3
2.44
1.91
mmol/l
—
5
36
482
4747
1.10
0.33
3.8
3.9
1.14
1.26
mmol/l
5.39
449
4328
131
1394
0.92
0.33
1.6
1.7
1.24
1.38
mmol/l
1.28
104
1173
6
88
0.68
0.33
1.2
1.5
—
—
—
0
0
6
88
0.68
0.33
1.2
1.4
—
—
—
0
0
6
88
0.68
0.33
1.2
1.5
—
—
—
0
0
39
343
1.15
0.31
2.1
3.0
4.12
4.47
pmol/l
1.48
30
300
20
166
1.21
0.30
1.5
1.1
—
—
—
0
0
7
55
1.28
0.30
4.0
3.5
—
—
—
0
0
7
57
1.23
0.29
1.0
1.1
—
—
—
0
0
39
346
1.14
0.28
3.9
4.1
17.59
22.49
%
1.45
20
158
16
191
0.83
0.25
1.2
1.9
1.49
2.39
mg/l
1.76
16
140
31
274
1.14
0.24
1.8
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
22.72
—
0
13
0
13
0.00
0.21
0.0
2.5
—
2.54
—
0
5
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
6
50
1.20
0.19
1.0
1.0
—
—
—
0
0
497
4925
1.07
0.19
4.2
4.4
1.63
1.57
mmol/l
1.98
465
4525
19
166
1.15
0.18
1.5
1.1
—
—
—
0
0
14
119
1.18
0.18
1.9
2.1
14.97
10.95
nmol/l
—
8
112
7
60
1.17
0.18
1.0
1.1
—
—
—
0
0
498
4942
1.06
0.16
4.3
4.4
4.64
4.85
mmol/l
4.54
467
4563
47
439
1.08
0.15
5.1
4.5
2.65
2.77
ug/l
0.03
41
390
14
122
1.15
0.14
1.7
1.3
—
—
—
0
0
28
260
1.08
0.11
2.5
2.8
0.44
0.77
ug/l
2.46
17
165
16
146
1.10
0.08
1.4
1.6
345.09
301.70
mu/l
0.16
11
134
7
80
0.87
0.07
1.1
1.0
—
—
—
0
0
13
118
1.10
0.07
1.2
1.1
—
—
—
0
0
16
172
0.93
0.06
1.8
1.6
—
—
—
0
0
16
149
1.08
0.05
1.3
1.3
235.83
261.03
miu/ml
—
6
71
11
101
1.09
0.04
7.0
1.6
0.84
0.84
nmol/l
0.01
11
82
26
271
0.96
0.04
1.5
1.3
33.12
32.59
iu/l
0.02
20
236
39
399
0.98
0.02
1.1
1.2
56.40
156.13
iu/ml
—
10
178
16
155
1.03
0.00
1.4
1.2
—
—
—
0
0
26
264
0.98
0.00
1.0
1.1
—
—
—
0
0
22
223
0.99
0.00
2.2
1.7
—
—
—
0
0
504
5036
1.01
0.00
4.6
5.0
2.63
2.86
mmol/l
7.00
474
4632
52
517
1.01
0.00
2.3
3.9
5.05
8.56
ug/l
1.12
39
417
485
4849
1.00
0.00
4.1
4.5
5.49
5.87
mmol/l
15.33
451
4426
0
9
0.00
0.00
0.0
1.0
—
113.44
—
0
9
7
79
0.88
0.00
1.0
1.2
50.40
16.21
u/l
—
7
69
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
65.67
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
7
70
1.00
-0.00
1.4
1.1
—
15.55
—
0
6
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
6
69
0.87
-0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint CREST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CREST | 2.418 [2.09, 2.8] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 370 out of 1714 females with CREST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CREST | 2.657 [1.86, 3.8] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 263 males with CREST died.
Mortality risk
Mortality risk for people of age
years, who have CREST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.263% | 0.492% |
| 5 | 1.279% | 3.229% |
| 10 | 3.077% | 7.7% |
| 15 | 6.036% | 14.045% |
| 20 | 10.835% | 23.099% |
Relationships between endpoints
↥Index endpoint: CREST – CR(E)ST syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data