scleroderma: Scleroderma is a rare autoimmune connective tissue disorder characterized by abnormal hardening of the skin and, sometimes, other organs. It is classified into two main forms: localized scleroderma and systemic sclerosis (SSc), the latter comprising three subsets; diffuse cutaneous SSc (dcSSc), limited cutaneous SSc (lcSSc) and limited SSc (lSSc) (see these terms).
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditions
|
898 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
330 |
4. Check minimum number of eventsNone |
330 |
5. Include endpointsNone |
330 |
6. Filter based on genotype QC (FinnGen only) |
320 |
Control definitions (FinnGen only)
- Control conditions
- not SYSTSCLE_ICD10
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Systemic sclerosis,strict definition
based on the number of shared cases.
Similar with more cases:
- Systemic sclerosis, icd10
- Systemic sclerosis (FG)
- Systemic sclerosis
- Systemic connective tissue disorders
- Reimbursement for rheumatic diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1154 | 971 | 174 |
| Only index persons | 1108 | 946 | 162 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.00 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.01 | 56.13 | 55.70 |
| Only index persons | 55.73 | 55.79 | 55.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 320 | 277 | 43 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.02 |
| Median age at first event (years) | 55.00 | 54.51 | 58.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 330
- Matched controls
- 3300
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
+∞
315.0
330
231
M34.1
ICD-10 Finland
CR(E)ST syndrome
+∞
313.9
249
*
C08CA05
ATC
nifedipine; systemic
48.9
269.1
182
81
P01BA02
ATC
hydroxychloroquine; oral
34.7
249.6
221
182
L04AX03
ATC
methotrexate; systemic
27.2
216.8
215
212
I73.0
ICD-10 Finland
Raynaud syndrome
69.1
201.5
114
25
XX9XE
NOMESCO Finland
Other ultrasound examination
139.0
194.3
98
10
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
2897.9
176.8
155
*
L04AA06
ATC
mycophenolic acid; systemic
51.0
145.7
87
23
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
19.6
105.7
91
63
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
12.9
100.0
118
137
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
35.4
93.7
61
21
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
14.8
80.6
80
70
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
9.2
77.5
120
193
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
12.4
71.0
79
82
L88
ICPC
Rheumatoid/seropositive arthritis
12.8
68.7
74
73
L04AX01
ATC
azathioprine; systemic
14.8
68.1
66
55
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
62.5
58
*
XPX04
NOMESCO Finland
Angioscopy
359.1
60.4
59
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.8
56.8
197
667
C08CA02
ATC
felodipine; oral
8.9
54.7
78
111
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
17.4
51.2
44
29
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
48.1
45
*
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
+∞
48.1
45
*
G04BE03
ATC
sildenafil; oral
79.8
43.3
48
7
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.1
43.0
232
1051
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.8
42.3
145
465
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
12.9
41.3
42
37
R4120
NOMESCO Finland
Occupational therapy
7.1
40.2
69
119
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
13.3
38.3
38
32
XG410
NOMESCO Finland
Flow-volume spirometry
9.2
35.5
46
57
NH3EA
NOMESCO Finland
Feet X-ray examination with load
13.4
34.7
34
28
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
369.4
33.5
33
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
5.2
31.9
78
186
GD1AD
NOMESCO Finland
Thorax CT examination
6.5
26.7
47
82
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.5
25.5
72
191
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.8
24.8
64
158
H02AB06
ATC
prednisolone; systemic
3.4
24.7
217
1196
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
9.6
24.6
30
34
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
9.5
23.6
29
33
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.7
23.0
91
307
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
21.7
172
874
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
36.6
21.5
27
8
L01BA01
ATC
methotrexate; systemic
7.0
21.4
34
53
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.6
21.3
57
144
M34
ICD-10 Finland
Systemic sclerosis
+∞
21.1
20
*
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
20.0
19
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
4.3
18.9
55
148
C08CA01
ATC
amlodipine; oral
2.8
18.6
155
792
C02KX04
ATC
macitentan; oral
+∞
17.9
17
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
18.7
17.2
26
15
RT172, ,
NOMESCO Finland
95.0
16.7
18
*
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
20.5
15.8
23
12
RT160, ,
NOMESCO Finland
+∞
15.7
15
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
89.4
15.7
17
*
E0000UV, ,
ATC
2.6
15.7
183
1079
L04AD01
ATC
ciclosporin; systemic
12.1
15.6
28
25
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
7.1
15.5
24
36
RT274, ,
NOMESCO Finland
83.9
14.7
16
*
C02KX01
ATC
bosentan; oral
+∞
14.7
14
*
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.8
14.3
48
142
WZA10
NOMESCO Finland
Extensive medical or dental certificate
12.8
13.8
24
20
Z01.8
ICD-10 Finland
Other specified special examinations
2.6
13.0
102
490
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
13.0
12.8
22
18
L04AA01
ATC
[U] ciclosporin
18.2
12.7
19
11
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
4.4
12.4
32
78
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
15.4
11.9
19
13
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
3.4
11.8
45
145
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.5
11.7
43
135
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
23.9
11.7
16
7
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
124.2
11.5
12
*
M35.1
ICD-10 Finland
Other overlap syndromes
26.1
11.2
15
6
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.2
11.0
176
1132
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
4.5
10.5
26
61
UJF30
NOMESCO Finland
Ileoscopy through colon
2.9
10.4
52
197
L03.0
ICD-10 Finland
Cellulitis of finger and toe
3.2
10.2
44
153
RT271, ,
NOMESCO Finland
56.7
9.7
11
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.9
9.5
29
80
I27.0
ICD-10 Finland
Primary pulmonary hypertension
102.9
9.5
10
*
A02BC05
ATC
esomeprazole; systemic
2.0
9.3
164
1074
A02BC02
ATC
pantoprazole; systemic
2.2
9.1
248
1898
R15
ICD-10 Finland
Faecal incontinence
4.4
9.1
23
55
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
9.0
85
436
UJF32
NOMESCO Finland
Coloscopy
2.2
8.9
102
566
R06.0
ICD-10 Finland
Dyspnoea
2.1
8.6
104
588
PHD76
NOMESCO Finland
Resection of long saphenous vein
3.6
8.6
29
86
S09
ICPC
Infected finger/toe
4.5
8.5
21
49
PB1BC
NOMESCO Finland
Extensive angiography of upper extremity with X-ray
92.3
8.5
9
*
I27.8
ICD-10 Finland
Other specified pulmonary heart diseases
+∞
8.4
8
*
I73.1
ICD-10 Finland
Thromboangiitis obliterans [Buerger]
+∞
8.4
8
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.4
8.3
62
287
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
5.0
8.2
18
38
NDR20
NOMESCO Finland
Incomplete excision of soft tissue tumour of wrist or hand
10.4
8.1
15
15
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.2
7.9
33
112
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
7.3
7.9
18
26
L95
ICPC
Osteoporosis
4.1
7.8
22
57
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
4.1
7.8
22
57
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
7.7
63
303
R4190
NOMESCO Finland
Nutritional therapy
4.0
7.7
22
58
K22.1
ICD-10 Finland
Ulcer of oesophagus
12.2
7.6
13
11
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.1
7.6
33
115
C08DB01
ATC
diltiazem; oral
4.1
7.6
21
54
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
7.5
156
1057
SPAT1263
SPAT
Sampling
1.9
7.4
154
1042
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
7.3
7
*
G04BE08
ATC
tadalafil; oral
+∞
7.3
7
*
RT310, ,
NOMESCO Finland
30.7
7.2
9
*
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
2.7
7.1
40
161
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
7.1
36
137
J01FF01
ATC
clindamycin; systemic
2.0
7.1
104
626
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
6.3
6.9
17
28
S18
ICPC
Laceration/cut
1.8
6.9
158
1097
C03CA01
ATC
furosemide; systemic
2.0
6.8
85
481
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.3
6.8
53
249
RT231, ,
NOMESCO Finland
40.9
6.8
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
6.8
50
229
GD2SN
NOMESCO Finland
Lung ventilation SPECT
23.1
6.7
9
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.2
6.7
66
342
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.1
6.7
29
101
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
6.6
141
954
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.0
6.6
79
441
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.8
6.5
34
131
RT272, ,
NOMESCO Finland
14.7
6.4
10
7
M43.9
ICD-10 Finland
Deforming dorsopathy, unspecified
+∞
6.3
6
*
L94.3
ICD-10 Finland
Sclerodactyly
+∞
6.3
6
*
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.4
6.3
44
197
PD4AD
NOMESCO Finland
CT of lower extremity arteries
27.2
6.3
8
*
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
27.2
6.3
8
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
7.9
6.2
13
17
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
8.8
6.1
12
14
R13
ICD-10 Finland
Dysphagia
2.8
6.1
32
124
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
161
96
31.80
208.51
1.6
1.2
2.41
2.67
u/ml
0.12
51
12
161
97
31.46
207.49
1.6
1.2
6.93
7.89
u/ml
0.06
75
19
164
106
29.77
204.58
1.6
1.2
3.60
3.14
u/ml
—
11
8
126
81
24.55
154.72
1.6
1.2
24.03
28.25
u/ml
0.08
26
11
122
76
24.88
151.87
1.5
1.2
0.46
—
u/ml
—
5
0
274
693
18.41
129.06
5.3
3.1
551.11
862.11
ng/l
1.90
258
581
126
114
17.26
127.50
2.3
1.8
—
—
—
0
0
126
125
15.69
120.04
1.7
1.3
8.21
1.34
u/ml
—
16
8
213
441
11.80
116.24
1.8
1.4
2180.36
412.67
titre
24.49
165
101
56
11
61.11
98.96
2.6
1.2
8.26
8.86
ug/l
0.17
56
11
322
1447
51.59
94.15
14.4
5.7
1.63
1.97
e9/l
3.74
316
1299
322
1468
50.27
92.35
14.6
6.1
0.19
0.18
e9/l
0.98
316
1308
321
1644
35.93
76.79
18.0
9.2
3.73
3.98
e9/l
1.78
313
1449
50
28
20.87
63.24
1.2
1.3
—
—
—
0
0
50
28
20.87
63.24
1.2
1.3
—
—
—
0
0
50
29
20.14
62.21
1.2
1.2
—
—
—
0
0
50
29
20.14
62.21
1.2
1.2
—
—
—
0
0
50
29
20.14
62.21
1.2
1.2
—
—
—
0
0
218
809
5.99
56.28
2.9
2.1
92.38
143.70
u/l
4.17
211
771
43
29
16.90
49.40
1.4
1.2
8.73
72.20
u/ml
—
11
5
263
1379
5.47
38.68
5.7
3.5
0.00
0.00
estimate
-0.00
68
286
48
58
9.51
37.82
1.7
2.1
125.06
131.79
g/l
0.67
16
42
262
1396
5.26
37.00
7.2
4.6
0.00
0.00
estimate
-0.00
67
275
263
1413
5.24
36.53
5.7
3.5
0.00
0.01
estimate
0.50
68
269
320
2176
16.53
30.05
14.4
7.1
72.28
76.36
u/l
1.57
320
2028
163
693
3.67
29.97
3.1
2.5
317.97
5977.69
umol/l
2.98
157
600
43
81
5.95
22.49
1.5
1.7
0.01
0.10
iu/ml
—
5
7
212
1231
3.02
20.58
2.9
2.3
78.92
77.72
nmol/l
0.30
203
1103
33
53
6.81
20.14
3.1
3.5
3.81
4.81
e9/l
1.23
33
53
33
54
6.68
19.78
3.1
3.9
56.36
59.35
%
0.62
33
54
217
1322
2.87
18.44
8.6
6.1
1.21
1.22
mmol/l
2.57
186
1120
148
765
2.69
17.03
7.1
3.7
0.00
0.00
estimate
-0.00
68
274
124
590
2.76
16.76
1.3
1.3
25.66
37.00
iu/ml
0.74
55
207
199
1206
2.64
16.31
7.8
5.3
1.21
1.22
mmol/l
1.68
188
1106
114
531
2.75
15.93
2.6
2.4
4.24
6.86
e6/l
0.84
107
483
24
15
17.14
15.49
1.2
1.1
—
—
—
0
0
97
423
2.83
15.31
2.7
2.4
0.78
1.17
e6/l
1.38
79
237
135
708
2.53
14.60
3.3
2.7
0.14
0.35
e6/l
1.87
122
521
160
920
2.43
14.02
4.9
2.8
—
—
—
0
0
32
76
4.56
12.76
2.4
2.2
—
—
—
0
0
324
2850
8.52
12.42
26.6
12.2
17.46
20.70
mg/l
1.14
268
2200
84
375
2.66
12.40
2.4
1.9
—
—
—
0
0
174
1098
2.24
11.60
6.5
3.5
—
—
—
0
0
22
43
5.41
10.94
1.3
1.1
11.29
1.58
u/ml
—
7
12
115
625
2.29
10.88
3.6
2.1
3.55
3.08
mg/l
0.97
107
529
61
256
2.70
10.03
2.2
1.8
—
—
—
0
0
106
580
2.22
9.70
1.3
1.3
3.62
9.37
u/ml
1.43
42
230
169
1106
2.08
9.70
5.7
4.2
35.87
36.06
g/l
0.17
164
1046
60
256
2.64
9.53
11.7
6.9
0.30
1.34
mmol/l
1.42
48
210
19
38
5.24
9.21
1.9
1.7
—
—
—
0
0
24
60
4.24
8.95
1.5
1.4
—
—
—
0
0
13
9
14.97
8.27
1.4
1.0
—
—
—
0
0
104
599
2.08
8.14
7.6
3.8
1.02
1.02
kg/l
—
6
73
20
33
6.38
7.98
2.3
1.9
—
—
—
0
0
57
259
2.45
7.89
2.3
1.9
—
—
—
0
0
20
48
4.37
7.85
1.4
1.1
3.00
4.32
u/ml
0.35
13
19
44
180
2.67
7.55
2.5
1.5
—
—
—
0
0
59
278
2.37
7.53
11.8
6.3
104.05
104.36
mmol/l
0.18
59
278
17
39
4.54
7.04
2.1
1.7
—
—
—
0
0
35
132
2.85
6.99
5.1
3.7
1.35
1.66
mmol/l
0.24
25
98
14
17
8.55
6.89
2.2
2.0
—
—
—
0
0
27
89
3.21
6.79
2.0
2.1
1.80
1.62
g/l
0.37
21
75
42
177
2.57
6.78
6.5
7.5
7.90
8.39
mmol/l
0.20
42
168
19
50
3.97
6.63
1.9
1.7
—
—
—
0
0
21
61
3.61
6.40
3.6
2.9
24.30
24.38
mmol/l
0.03
21
61
20
58
3.61
6.11
1.1
2.0
—
—
—
0
0
142
981
1.79
6.07
4.9
3.3
26.82
24.80
ng/l
0.13
101
623
9
6
15.36
5.93
1.7
1.0
—
—
—
0
0
15
26
5.99
5.91
1.6
1.6
—
—
—
0
0
17
45
3.93
5.89
2.1
1.7
—
—
—
0
0
13
19
7.08
5.79
1.3
1.2
—
—
—
0
0
22
71
3.25
5.73
1.4
1.1
—
—
—
0
0
17
36
4.92
5.69
1.1
1.1
—
—
—
0
0
189
1456
1.70
5.20
7.1
5.9
9.25
9.86
umol/l
0.78
178
1378
21
70
3.14
5.20
2.0
1.7
—
—
—
0
0
20
65
3.21
5.16
2.0
1.8
—
—
—
0
0
61
338
1.99
5.11
3.4
2.2
19.55
22.45
%
0.91
51
286
13
24
5.59
4.96
1.2
1.1
—
—
—
0
0
155
1144
1.67
4.94
12.6
10.1
1.18
1.16
inr
0.09
46
358
28
114
2.59
4.86
1.8
1.6
—
—
—
0
0
15
34
4.57
4.81
2.1
1.6
—
—
—
0
0
70
416
1.87
4.75
4.6
3.5
0.81
0.81
mmol/l
0.00
64
397
18
58
3.22
4.71
3.9
3.3
6.91
8.33
kpa
1.83
18
58
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
18
58
3.22
4.71
2.7
2.2
0.52
0.38
u/ml
0.56
11
32
15
43
3.61
4.67
1.1
1.1
99.87
119.00
%
1.84
15
38
21
75
2.92
4.64
1.2
1.2
—
—
—
0
0
14
31
4.67
4.61
2.2
1.6
61.00
53.89
%
—
6
19
14
31
4.67
4.61
1.9
1.3
—
—
—
0
0
12
24
5.15
4.36
1.0
1.6
—
—
—
0
0
72
445
1.79
4.29
1.7
1.7
1197.48
1203.94
nmol/l
0.02
63
323
30
136
2.33
4.17
1.7
1.3
—
—
—
0
0
15
48
3.23
3.98
1.5
1.3
—
—
—
0
0
11
23
4.91
3.90
1.1
1.7
—
—
—
0
0
11
23
4.91
3.90
1.1
1.7
—
—
—
0
0
11
23
4.91
3.90
1.1
1.7
—
—
—
0
0
16
54
3.06
3.90
1.1
1.2
—
—
—
0
0
100
693
1.64
3.89
1.3
1.3
0.51
1.93
u/ml
1.51
27
203
13
33
4.06
3.84
1.2
1.0
89.62
100.89
%
0.66
13
28
13
33
4.06
3.84
1.1
1.1
—
—
—
0
0
18
66
2.83
3.82
1.5
1.4
—
—
—
0
0
94
647
1.63
3.74
2.0
1.7
1.22
0.90
mg/l
0.89
79
501
23
97
2.47
3.74
1.9
1.8
—
—
—
0
0
281
2513
1.80
3.55
31.1
14.9
14.95
14.84
%
0.16
281
2480
8
13
6.28
3.52
1.8
4.1
—
—
—
0
0
14
47
3.07
3.45
1.1
1.0
—
—
—
0
0
43
244
1.88
3.35
2.7
2.4
63.61
68.59
ml/min/173m2
0.39
23
102
8
15
5.44
3.21
2.9
1.4
—
—
—
0
0
8
15
5.44
3.21
2.9
1.4
—
—
—
0
0
8
15
5.44
3.21
2.9
1.4
—
—
—
0
0
7
11
6.47
3.20
1.0
1.1
10.29
14.45
u/l
—
7
11
17
67
2.62
3.18
1.8
1.5
—
—
—
0
0
137
1060
1.50
3.17
1.9
1.8
89.69
100.11
pmol/l
2.02
75
515
165
1329
1.48
3.12
3.8
2.7
90.98
88.43
ug/l
0.08
159
1229
21
93
2.34
3.10
1.8
1.7
—
—
—
0
0
14
51
2.82
3.02
1.4
1.8
—
—
—
0
0
14
51
2.82
3.02
1.4
1.8
—
—
—
0
0
10
26
3.93
3.00
1.8
1.8
—
—
—
0
0
72
488
1.61
3.00
4.0
3.6
152.23
345.65
ng/l
0.54
56
349
19
82
2.40
2.97
3.5
2.0
100.21
96.84
%
0.39
19
76
214
1826
1.49
2.96
4.8
4.2
—
163.37
—
0
27
124
954
1.48
2.90
2.7
3.4
2.35
2.36
mmol/l
0.52
117
842
6
9
6.76
2.88
1.0
2.0
—
—
—
0
0
6
9
6.76
2.88
1.0
2.0
—
—
—
0
0
6
9
6.76
2.88
1.0
2.0
—
—
—
0
0
120
919
1.48
2.86
4.2
3.0
29.66
28.91
u/l
0.18
115
877
86
616
1.54
2.82
1.6
1.4
21.04
22.07
nmol/l
0.27
77
507
33
182
1.90
2.81
2.8
2.3
30.70
7.36
ug/l
0.41
26
158
6
10
6.09
2.71
1.8
1.8
26.50
30.50
umol/l
—
6
10
260
2329
1.55
2.69
4.6
4.3
15.26
14.62
pmol/l
4.13
247
2149
10
30
3.40
2.62
1.8
1.7
—
—
—
0
0
7
15
4.74
2.61
1.0
1.7
—
—
—
0
0
7
15
4.74
2.61
1.0
1.7
—
—
—
0
0
10
32
3.19
2.45
2.8
1.6
—
—
—
0
0
13
52
2.56
2.39
1.8
1.5
—
—
—
0
0
20
98
2.11
2.37
1.9
1.3
229.18
307.37
ug/g
—
9
59
35
212
1.73
2.24
3.8
3.5
1.15
2.17
mmol/l
0.86
28
174
11
41
2.74
2.23
2.3
1.6
—
—
—
0
0
51
343
1.58
2.19
9.7
5.8
—
—
—
0
0
179
1529
1.37
2.14
7.7
4.2
6.27
6.49
mmol/l
1.07
170
1421
10
37
2.75
2.09
1.3
1.2
—
—
—
0
0
7
20
3.55
2.06
3.0
1.5
—
—
—
0
0
7
20
3.55
2.06
1.3
1.8
926.57
615.80
e6/l
—
7
20
12
50
2.45
2.05
1.5
1.3
—
—
—
0
0
19
97
2.02
2.04
1.2
1.7
2.91
2.94
g/l
0.05
19
89
45
299
1.58
2.04
1.6
2.5
4.73
6.37
umol/l
1.22
38
250
218
1934
1.37
1.99
3.2
3.2
—
—
—
0
0
25
142
1.82
1.99
1.4
1.4
—
—
—
0
0
6
16
3.80
1.94
1.0
1.1
—
—
—
0
0
6
17
3.57
1.84
1.2
1.1
12.17
15.81
u/l
—
6
17
6
17
3.57
1.84
1.2
1.1
75.67
58.00
u/l
—
6
17
14
67
2.14
1.78
1.2
1.1
3.00
4.22
e6/l
—
9
55
14
67
2.14
1.78
2.4
4.0
—
2.65
—
0
10
19
103
1.90
1.75
1.2
1.7
3.08
3.58
g/l
1.96
19
95
19
103
1.90
1.75
1.2
1.7
—
—
—
0
0
19
103
1.90
1.75
1.2
1.7
7.53
7.57
g/l
0.04
19
95
53
379
1.47
1.74
3.4
2.6
6.22
3.59
e6/l
0.50
34
195
14
68
2.11
1.73
2.5
4.0
116.36
36.79
mg/l
—
9
52
14
68
2.11
1.73
2.5
4.0
27.51
24.28
mg/l
—
9
50
17
90
1.94
1.68
1.2
2.6
10.79
10.19
mg/l
0.11
17
83
5
14
3.61
1.62
1.0
2.1
91.80
57.74
ug/l
—
5
14
105
857
1.33
1.59
2.9
2.3
57.61
56.14
u/l
0.17
96
784
5
15
3.37
1.53
1.2
1.7
—
—
—
0
0
7
28
2.53
1.46
1.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
16
3.16
1.44
1.0
1.1
—
—
—
0
0
5
16
3.16
1.44
1.2
1.1
—
—
—
0
0
5
16
3.16
1.44
1.0
1.3
3.08
1.76
mmol/l
—
5
16
0
38
0.00
1.35
0.0
1.6
—
—
—
0
0
289
2745
1.43
1.32
20.7
11.3
82.07
83.63
ml/min/173m2
0.70
275
2234
81
654
1.32
1.31
3.0
2.0
—
—
—
0
0
5
18
2.80
1.29
1.4
1.3
—
—
—
0
0
286
2716
1.40
1.26
5.6
5.0
1.97
2.28
mu/l
0.32
276
2512
8
36
2.25
1.25
1.6
1.8
—
—
—
0
0
8
36
2.25
1.25
1.6
1.8
—
—
—
0
0
16
93
1.76
1.23
1.3
1.7
9.21
9.87
g/l
0.34
16
84
10
50
2.03
1.17
1.7
1.3
—
—
—
0
0
10
50
2.03
1.17
1.7
1.3
—
—
—
0
0
21
136
1.58
1.11
1.5
2.6
42.38
41.31
u/l
0.09
21
120
324
3177
2.09
1.07
42.4
18.4
39.83
40.11
%
0.56
308
2996
15
91
1.68
1.02
1.3
1.9
1.23
0.71
g/l
0.16
15
82
22
317
0.67
1.01
1.2
1.7
1.47
1.39
%
0.22
17
282
16
102
1.60
0.92
1.4
1.3
176.43
281.13
miu/ml
—
7
46
21
299
0.68
0.91
1.7
1.7
—
—
—
0
0
67
554
1.26
0.91
1.5
1.7
505.53
10870018.79
pmol/l
0.50
59
460
24
171
1.44
0.86
1.8
1.4
—
—
—
0
0
21
294
0.69
0.84
2.1
4.1
3.44
7.55
ug/l
1.38
16
243
11
65
1.72
0.83
1.5
1.3
—
—
—
0
0
15
97
1.57
0.83
1.7
1.2
—
—
—
0
0
17
114
1.52
0.81
3.9
2.6
0.64
0.65
%
0.06
17
114
19
131
1.48
0.80
1.9
1.6
—
—
—
0
0
15
98
1.56
0.80
1.7
1.2
—
—
—
0
0
253
2641
0.82
0.77
4.6
5.2
37.52
38.99
mmol/mol
2.31
239
2470
13
83
1.59
0.76
1.3
1.8
37.21
38.43
g/l
0.39
13
75
9
54
1.69
0.75
1.2
1.3
—
—
—
0
0
7
38
1.86
0.74
1.6
1.3
—
—
—
0
0
7
38
1.86
0.74
1.6
1.3
—
—
—
0
0
7
38
1.86
0.74
1.6
1.3
—
—
—
0
0
7
38
1.86
0.74
1.6
1.3
—
—
—
0
0
5
25
2.01
0.73
2.8
3.4
—
—
—
0
0
7
39
1.81
0.73
1.6
1.3
—
—
—
0
0
17
118
1.46
0.71
4.4
2.6
1.11
1.13
%
0.04
17
118
77
672
1.19
0.64
1.5
1.4
—
—
—
0
0
19
139
1.39
0.62
16.4
6.0
24.19
25.29
mmol/l
0.77
19
139
283
2743
1.22
0.60
3.8
3.9
1.15
1.25
mmol/l
2.42
267
2528
68
591
1.19
0.59
1.6
1.5
—
—
—
0
0
71
806
0.85
0.57
1.5
1.7
1.25
1.40
mmol/l
0.86
64
680
6
38
1.59
0.54
1.7
1.3
—
—
—
0
0
69
780
0.85
0.53
4.2
3.6
20.16
7.97
mg/mmol
0.70
45
442
143
1329
1.13
0.51
3.3
2.3
—
—
—
0
0
32
264
1.23
0.48
4.6
3.2
—
—
—
0
0
26
319
0.80
0.47
1.5
1.9
—
—
—
0
0
8
121
0.65
0.46
1.3
1.5
—
—
—
0
0
291
2844
1.20
0.45
4.0
4.3
1.62
1.57
mmol/l
0.94
277
2634
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
—
—
0
0
184
1920
0.91
0.37
3.8
2.9
59.16
42.31
u/l
1.85
172
1803
291
2856
1.16
0.34
4.1
4.4
4.64
4.89
mmol/l
3.94
277
2658
41
360
1.16
0.34
4.1
4.4
33.91
33.34
%
0.12
34
229
19
155
1.24
0.33
1.0
1.0
—
—
—
0
0
10
74
1.36
0.32
1.9
1.8
—
—
—
0
0
283
2781
1.12
0.28
4.0
4.3
5.57
5.82
mmol/l
3.89
268
2568
16
132
1.22
0.26
2.0
2.5
0.09
0.10
e6/l
0.15
16
126
10
78
1.29
0.24
1.0
1.1
—
8.48
—
0
13
0
11
0.00
0.21
0.0
1.0
—
1889.18
—
0
11
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
11
0.00
0.21
0.0
1.0
—
136.91
—
0
11
0
11
0.00
0.21
0.0
1.0
—
105.40
—
0
5
0
11
0.00
0.21
0.0
1.0
—
114.80
—
0
5
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
23.43
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
7.55
—
0
13
16
136
1.19
0.20
1.6
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
5
66
0.75
0.17
1.0
1.5
—
—
—
0
0
5
66
0.75
0.17
1.0
1.5
—
—
—
0
0
5
66
0.75
0.17
1.0
1.4
—
—
—
0
0
26
285
0.90
0.15
1.3
1.8
—
—
—
0
0
15
168
0.89
0.12
2.0
1.8
—
—
—
0
0
5
47
1.06
0.09
4.8
1.3
0.67
0.94
nmol/l
—
5
39
21
227
0.92
0.09
2.3
4.1
18.27
21.86
%
—
9
104
7
81
0.86
0.07
1.4
1.2
—
—
—
0
0
7
82
0.85
0.07
1.0
1.1
—
—
—
0
0
9
86
1.05
0.07
1.3
1.2
—
—
—
0
0
292
2905
1.04
0.06
4.5
4.9
2.62
2.90
mmol/l
6.46
278
2690
12
130
0.92
0.04
1.7
1.7
—
—
—
0
0
10
98
1.02
0.00
1.4
1.6
—
—
—
0
0
17
175
0.97
0.00
1.7
2.7
0.44
0.79
ug/l
—
10
108
20
204
0.98
0.00
1.6
3.1
4.43
4.52
pmol/l
0.22
15
183
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.67
—
0
6
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
75.60
—
0
5
0
5
0.00
0.00
0.0
1.0
—
52.40
—
0
5
0
5
0.00
0.00
0.0
1.2
—
409.80
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
108.50
—
0
6
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint SYSTSCLE_STRICT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SYSTSCLE_STRICT | 2.104 [1.69, 2.63] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.582 |
During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 823 females with SYSTSCLE_STRICT died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have SYSTSCLE_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.201% | No data |
| 5 | 1.155% | No data |
| 10 | 3.086% | No data |
| 15 | 6.121% | No data |
| 20 | 10.651% | No data |
Relationships between endpoints
↥Index endpoint: SYSTSCLE_STRICT – Systemic sclerosis,strict definition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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