Progressive systemic sclerosis

M13_PROGRESSIVE_SYSTEMIC_SCLEROSIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M34.0
  • Cause of death: ICD-10 M34.0

2 out of 7 registries used, show all original rules.

166

4. Check minimum number of events

None

166

5. Include endpoints

None

166

6. Filter based on genotype QC (FinnGen only)

161

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 161 133 28
Unadjusted period prevalence (%) 0.04 0.05 0.01
Median age at first event (years) 54.70 52.75 63.96

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
166
Matched controls
1660
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M34.0
ICD-10 Finland
Progressive systemic sclerosis
+∞
240.1
166
*
C08CA05
ATC
nifedipine; systemic
43.1
131.6
95
50
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
36.1
127.1
120
112
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
+∞
108.6
92
*
P01BA02
ATC
hydroxychloroquine; oral
21.0
90.5
94
97
M34.1
ICD-10 Finland
CR(E)ST syndrome
270.2
78.9
75
5
L04AX01
ATC
azathioprine; systemic
26.9
63.1
47
24
L04AX03
ATC
methotrexate; systemic
13.6
61.3
76
97
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
11.8
42.8
52
62
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
12.7
38.2
42
43
M34.8
ICD-10 Finland
Other forms of systemic sclerosis
+∞
38.0
35
*
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
50.5
35.5
42
11
XG410
NOMESCO Finland
Flow-volume spirometry
12.1
31.5
35
36
L04AA06
ATC
mycophenolic acid; systemic
44.2
31.3
38
11
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
12.2
30.2
33
33
XX9XE
NOMESCO Finland
Other ultrasound examination
78.6
29.1
32
5
I73.0
ICD-10 Finland
Raynaud syndrome
34.9
28.1
36
13
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.7
27.4
103
372
M34
ICD-10 Finland
Systemic sclerosis
+∞
26.8
25
*
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
6.9
26.8
51
100
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
7.4
24.6
42
73
XPX04
NOMESCO Finland
Angioscopy
278.5
24.3
24
*
G04BE03
ATC
sildenafil; oral
76.4
23.6
26
*
GD1AD
NOMESCO Finland
Thorax CT examination
9.3
23.4
31
40
L88
ICPC
Rheumatoid/seropositive arthritis
9.4
22.9
30
38
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.6
22.4
126
599
L04AA01
ATC
[U] ciclosporin
58.4
21.8
25
5
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.4
19.5
37
71
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
30.8
18.4
24
9
H02AB06
ATC
prednisolone; systemic
4.7
18.1
124
643
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
15.7
17.8
29
22
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
47.7
17.7
21
5
TPH04
NOMESCO Finland
Cathetrisation of vein
4.2
17.3
66
226
J99.1*M34.8
ICD-10 Finland
Respiratory disorders in systemic: sclerosis
+∞
17.0
16
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
4.2
16.4
59
193
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
13.8
15.7
27
23
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.8
15.4
72
280
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
50.1
15.4
18
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.8
15.1
67
251
L95
ICPC
Osteoporosis
7.0
15.1
25
41
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
13.2
14.9
26
23
J01FF01
ATC
clindamycin; systemic
3.6
14.8
79
334
SPAT1148
SPAT
Treatment of chronic ulcer or burn
4.4
14.2
44
127
C02KX01
ATC
bosentan; oral
+∞
13.7
13
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
+∞
13.7
13
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.7
13.6
36
92
L01BA01
ATC
methotrexate; systemic
11.6
13.5
25
25
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
4.6
13.5
37
97
M05BX04
ATC
denosumab; parenteral
5.2
13.2
30
67
H02AB07
ATC
prednisone; oral
4.0
13.2
47
150
L04AD01
ATC
ciclosporin; systemic
17.3
13.0
20
13
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
5.4
12.9
28
60
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.7
12.4
33
84
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.2
12.2
99
523
C08CA02
ATC
felodipine; oral
4.7
12.1
32
81
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
5.2
11.9
27
60
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
15.1
11.8
19
14
I27.0
ICD-10 Finland
Primary pulmonary hypertension
+∞
11.6
11
*
M01CC01
ATC
penicillamine; oral
+∞
11.6
11
*
7101A
ICD-9 Finland
Diffuse diseases of connective tissue, Systemic sclerosis[SCLERODERMA]
+∞
11.6
11
*
QC6S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in hand
128.6
11.6
12
*
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
14.1
11.5
19
15
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
4.3
11.4
33
90
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.8
11.1
28
68
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.3
11.0
32
87
M05BA04
ATC
alendronic acid; oral
3.9
11.0
38
118
R4120
NOMESCO Finland
Occupational therapy
5.0
10.7
25
57
ZX120
NOMESCO Finland
Intravenous
4.0
10.6
35
105
M35.1
ICD-10 Finland
Other overlap syndromes
117.1
10.5
11
*
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
20.4
10.5
15
8
E0000UV, ,
ATC
2.9
10.4
97
540
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
12.5
10.3
18
16
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
5.0
9.9
23
52
R06.0
ICD-10 Finland
Dyspnoea
2.9
9.7
69
330
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.0
9.6
22
49
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.3
9.5
45
170
XQ841
NOMESCO Finland
Examination of dermatosis with microscope
105.8
9.5
10
*
G73.7*M34.8
ICD-10 Finland
Myopathy in scleroderma
+∞
9.5
9
*
TGC00
NOMESCO Finland
Bronchial lavation
9.2
9.4
19
23
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
16.8
9.2
14
9
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
4.9
8.9
21
48
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.8
8.7
58
265
A02BC01
ATC
omeprazole; systemic
2.7
8.6
68
339
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
21.4
8.6
12
6
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
8.3
8.4
18
24
C02KX04
ATC
macitentan; oral
+∞
8.4
8
*
RT172, ,
NOMESCO Finland
+∞
8.4
8
*
C03DA01
ATC
spironolactone; oral
3.3
8.3
35
123
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.9
8.2
26
75
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
4.7
8.2
20
47
M05BA07
ATC
risedronic acid; oral
6.7
8.1
20
33
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
23.4
8.1
11
5
L99
ICPC
Musculoskeletal disease other
10.2
8.0
15
16
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
4.1
7.9
23
62
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
4.0
7.9
24
67
M13.9
ICD-10 Finland
Arthritis, unspecified
4.2
7.8
22
58
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.1
7.8
23
63
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
3.5
7.7
29
94
UJF32
NOMESCO Finland
Coloscopy
2.6
7.6
64
326
RT160, ,
NOMESCO Finland
83.7
7.5
8
*
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
11.6
7.4
13
12
M35.8
ICD-10 Finland
Other specified systemic involvement of connective tissue
+∞
7.3
7
*
E000001, ,
ATC
2.7
7.3
48
216
K74.3
ICD-10 Finland
Primary biliary cirrhosis
41.8
6.8
8
*
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
9.3
6.7
13
15
J96.1
ICD-10 Finland
Chronic respiratory failure
10.7
6.7
12
12
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
6.5
27
93
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
15.1
6.5
10
7
RT271, ,
NOMESCO Finland
72.5
6.5
7
*
C02DE02, ,
ATC
11.7
6.4
11
10
M43.0
ICD-10 Finland
Spondylolysis
11.7
6.4
11
10
C03CA01
ATC
furosemide; systemic
2.3
6.3
66
365
XQ860
NOMESCO Finland
Laser Doppler measurement/scan of capillary perfusion
+∞
6.3
6
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
6.5
6.2
15
25
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.3
6.1
68
387
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
6.0
30
115
R60.0
ICD-10 Finland
Localized oedema
2.8
6.0
34
140

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
53
56
13.43
47.77
1.6
1.3
7.98
0.32
u/ml
—
6
5
47
48
13.26
43.07
1.4
1.3
1.40
2.81
u/ml
—
13
8
47
49
12.99
42.46
1.5
1.3
8.47
2.84
u/ml
—
17
10
46
52
11.85
39.15
3.0
1.4
1.05
1.13
g/l
0.80
46
52
84
202
7.39
37.23
1.8
1.3
1258.95
474.91
titre
3.34
57
55
141
655
8.65
28.32
19.8
6.1
—
—
—
0
0
110
440
5.45
25.33
5.9
3.2
754.68
969.18
ng/l
0.80
101
366
123
663
4.30
16.32
19.8
5.4
2.61
2.87
%
0.85
123
615
123
667
4.26
16.08
20.6
5.7
8.66
8.36
%
0.54
123
620
125
726
3.92
13.84
7.8
3.9
0.00
0.00
estimate
-0.00
24
128
124
717
3.88
13.81
7.8
3.9
0.00
0.00
estimate
-0.00
24
139
124
720
3.85
13.65
10.0
5.2
0.00
0.00
estimate
-0.00
24
126
38
101
4.58
13.64
7.5
4.4
0.24
0.62
%
0.76
21
33
40
117
4.19
12.62
8.3
4.3
0.75
0.76
%
0.02
24
44
21
37
6.35
11.80
2.0
1.7
127.33
128.52
g/l
—
9
23
53
199
3.44
11.54
3.1
2.3
16.70
22.00
%
2.45
45
166
26
58
5.13
11.41
1.8
1.4
—
—
—
0
0
75
350
3.08
11.31
4.4
2.1
3.74
3.44
mg/l
0.37
70
301
36
107
4.02
11.03
9.1
4.4
0.00
0.15
%
1.24
20
34
120
735
3.28
11.02
11.4
7.0
1.22
1.23
mmol/l
0.58
107
632
35
105
3.96
10.57
8.4
4.4
0.00
0.03
%
0.49
18
31
75
363
2.94
10.42
6.1
2.8
6197.52
5932.25
umol/l
0.01
65
302
70
328
2.96
10.30
7.9
4.3
1.01
1.02
kg/l
0.83
12
45
36
113
3.79
10.18
1.8
3.0
73.29
73.18
e9/l
0.01
29
90
49
194
3.16
9.61
2.8
2.1
—
—
—
0
0
151
1114
4.93
9.43
15.9
4.3
14.74
12.08
mm/h
1.75
151
1012
37
125
3.52
9.34
2.9
1.5
—
—
—
0
0
90
514
2.64
8.66
7.5
3.7
101.22
69.66
e6/l
0.19
74
354
67
332
2.71
8.58
7.2
3.9
—
—
—
0
0
108
677
2.70
8.55
10.3
6.1
1.22
1.22
mmol/l
0.43
101
614
41
157
3.14
8.41
3.0
1.6
—
—
—
0
0
107
672
2.67
8.37
15.5
12.4
1.16
1.20
inr
0.17
27
190
78
422
2.60
8.31
6.1
3.2
13.42
19.52
e6/l
0.90
71
317
86
489
2.57
8.24
5.3
3.8
7.40
7.40
ph
0.26
14
91
139
1006
3.35
8.16
12.3
4.3
—
—
—
0
0
59
281
2.71
8.10
4.4
3.6
593.79
125.63
ng/l
0.87
48
226
70
363
2.61
8.10
5.9
4.1
—
—
—
0
0
74
397
2.56
7.94
5.7
3.0
0.05
0.39
e6/l
4.77
66
295
37
140
3.11
7.71
1.8
1.9
359.22
383.90
nmol/l
0.27
32
131
99
625
2.45
7.27
21.9
9.4
0.00
0.00
e9/l
0.48
94
509
71
388
2.45
7.17
5.8
2.9
—
—
—
0
0
49
226
2.66
7.05
1.5
1.2
—
—
—
0
0
13
15
9.29
6.69
1.2
1.1
—
—
—
0
0
25
81
3.46
6.64
7.4
3.8
7.42
7.44
ph
—
5
10
22
67
3.63
6.40
1.2
1.3
—
—
—
0
0
9
5
18.91
6.33
2.4
2.0
39.11
36.16
%
—
9
5
9
5
18.91
6.33
2.7
1.6
0.02
0.14
e9/l
—
9
5
58
315
2.29
5.72
1.9
1.4
2.02
2.42
g/l
0.89
43
175
68
397
2.21
5.61
9.7
4.2
0.00
0.00
estimate
-0.00
24
132
27
102
2.97
5.57
2.6
2.9
—
—
—
0
0
15
29
5.58
5.54
1.1
2.2
—
—
—
0
0
68
401
2.18
5.44
6.6
3.4
—
—
—
0
0
11
14
8.32
5.44
2.9
1.3
—
—
—
0
0
34
148
2.63
5.39
11.5
10.0
1.10
1.36
mmol/l
0.14
29
119
14
26
5.78
5.36
1.3
1.3
—
—
—
0
0
23
82
3.10
5.23
1.2
1.4
—
—
—
0
0
14
27
5.56
5.21
2.6
1.9
—
—
—
0
0
32
138
2.63
5.16
1.4
1.4
—
—
—
0
0
8
6
13.91
5.13
2.1
1.2
—
—
—
0
0
31
133
2.64
5.04
6.9
3.6
—
—
—
0
0
24
90
2.95
5.01
4.6
9.4
—
—
—
0
0
65
387
2.12
5.00
11.5
7.1
—
—
—
0
0
14
30
5.00
4.81
1.8
7.4
—
—
—
0
0
15
35
4.61
4.77
7.5
2.0
24.45
24.55
mmol/l
0.03
15
35
12
22
5.79
4.70
3.2
4.0
—
—
—
0
0
9
11
8.57
4.62
2.2
1.1
32.61
25.92
g/l
—
9
11
10
16
6.57
4.36
1.2
1.4
—
—
—
0
0
8
9
9.26
4.33
2.0
1.2
—
—
—
0
0
40
207
2.23
4.30
4.8
3.0
4.02
3.62
e6/l
0.07
27
107
17
58
3.15
4.15
5.8
4.1
—
—
—
0
0
11
22
5.28
4.08
2.5
1.7
—
—
—
0
0
80
543
1.91
4.06
3.5
3.2
2.36
2.36
mmol/l
0.08
73
477
16
54
3.17
3.97
1.3
1.5
225.88
272.11
ug/g
—
8
31
11
23
5.04
3.95
7.5
1.9
—
—
—
0
0
9
15
6.27
3.87
2.7
3.8
—
—
—
0
0
71
470
1.89
3.84
3.0
2.4
58.38
55.17
u/l
0.39
64
438
26
118
2.43
3.75
3.6
3.0
75.68
76.06
ng/l
0.01
21
105
12
30
4.23
3.68
7.3
2.5
7.47
7.72
kpa
0.27
12
30
7
9
8.06
3.59
2.3
1.1
—
—
—
0
0
9
17
5.53
3.56
2.6
4.5
—
—
—
0
0
17
64
2.85
3.52
17.1
16.5
—
—
—
0
0
10
22
4.77
3.49
1.4
1.4
—
—
—
0
0
32
165
2.16
3.44
1.3
1.4
—
—
—
0
0
57
365
1.86
3.34
1.7
1.5
20.17
23.14
nmol/l
0.78
51
296
10
24
4.36
3.25
7.7
2.4
4.71
4.88
e9/l
—
10
24
10
24
4.36
3.25
8.5
3.0
60.30
61.38
%
—
10
24
14
50
2.97
3.17
6.4
4.8
24.06
25.49
mmol/l
0.91
14
50
35
193
2.03
3.16
3.2
1.5
—
—
—
0
0
6
8
7.73
3.08
1.0
4.0
81.50
110.88
nmol/l
—
6
8
7
12
6.03
3.05
2.9
1.8
635.00
357.58
e6/l
—
7
12
21
97
2.33
2.92
2.4
2.2
22.72
7.29
e9/l
0.37
15
76
44
279
1.79
2.59
1.2
1.3
64.94
42.83
iu/ml
0.19
14
101
82
619
1.64
2.53
2.0
1.9
98.44
99.71
pmol/l
0.09
52
277
13
51
2.68
2.51
3.6
2.8
0.37
0.18
g/l
—
8
11
15
64
2.48
2.47
19.6
9.1
23.72
24.46
mmol/l
0.36
15
64
16
72
2.35
2.36
4.8
2.7
0.07
0.13
e6/l
0.45
16
67
43
278
1.74
2.36
1.8
1.7
1239.67
1260.22
nmol/l
0.06
35
202
8
24
3.45
2.21
5.4
3.0
—
—
—
0
0
121
1026
1.66
2.20
7.6
4.0
—
—
—
0
0
23
126
1.96
2.11
6.0
3.3
1.95
2.36
mmol/l
0.19
18
102
9
31
3.01
2.10
8.4
2.9
7.54
8.65
kpa
—
9
31
73
555
1.56
2.08
6.8
3.9
28.82
35.98
ng/l
0.27
54
395
29
174
1.81
2.03
16.2
5.8
103.31
103.89
mmol/l
0.29
29
174
16
78
2.16
1.98
17.0
5.8
25.83
24.93
mmol/l
0.32
16
78
154
1414
2.23
1.98
38.7
14.4
19.27
21.41
mg/l
0.46
143
1094
20
107
1.99
1.96
19.6
7.1
—
—
—
0
0
9
33
2.82
1.96
1.2
1.3
—
—
—
0
0
7
22
3.27
1.90
1.4
1.5
—
—
—
0
0
23
131
1.88
1.89
5.7
3.4
—
—
—
0
0
66
499
1.54
1.89
4.8
3.2
—
—
—
0
0
31
194
1.74
1.89
1.2
1.6
—
—
—
0
0
16
80
2.11
1.87
20.4
8.0
0.56
0.72
%
0.64
16
80
5
12
4.26
1.83
1.0
1.3
—
—
—
0
0
16
82
2.05
1.76
20.5
7.8
1.11
1.58
%
1.76
16
82
7
25
2.88
1.67
1.9
1.8
—
—
—
0
0
33
474
0.62
1.66
2.2
3.1
—
—
—
0
0
5
14
3.65
1.62
1.2
1.2
—
—
—
0
0
21
123
1.81
1.60
1.2
1.2
—
—
—
0
0
6
20
3.07
1.59
1.0
1.1
—
—
—
0
0
49
360
1.51
1.57
1.4
1.2
0.44
1.44
u/ml
—
9
99
17
94
1.90
1.54
1.7
1.3
—
—
—
0
0
5
15
3.40
1.53
2.4
2.3
—
—
—
0
0
6
21
2.92
1.52
1.3
1.0
—
—
—
0
0
5
17
3.00
1.37
1.0
3.4
—
—
—
0
0
5
18
2.83
1.29
1.2
1.2
—
—
—
0
0
5
18
2.83
1.29
1.6
1.6
5.96
208.33
u/ml
—
5
18
5
19
2.68
1.22
1.4
1.1
—
—
—
0
0
14
80
1.82
1.17
2.8
2.4
—
—
—
0
0
57
454
1.39
1.16
2.9
2.3
—
—
—
0
0
5
20
2.54
1.16
1.4
1.3
31.20
31.95
pg
—
5
20
7
31
2.31
1.12
8.7
2.9
5.57
5.05
kpa
—
7
31
5
21
2.42
1.10
1.6
1.4
—
—
—
0
0
53
425
1.36
1.03
3.4
3.0
2789.33
358.16
mg/l
0.68
34
257
5
23
2.21
0.98
3.6
2.7
90.70
90.20
%
—
5
23
43
338
1.37
0.94
2.4
1.7
1.13
1.03
mg/l
0.11
37
263
18
119
1.57
0.92
2.6
1.4
—
—
—
0
0
17
111
1.59
0.92
12.1
3.8
—
—
—
0
0
132
1224
1.38
0.90
39.1
17.2
15.62
15.06
%
0.64
132
1208
10
57
1.80
0.85
7.3
3.6
—
—
—
0
0
8
45
1.82
0.85
2.4
2.6
—
—
—
0
0
0
24
0.00
0.80
0.0
1.1
—
—
—
0
0
35
275
1.35
0.77
1.3
1.3
1.29
12.89
u/ml
—
10
107
16
108
1.53
0.77
5.8
2.7
—
—
—
0
0
10
60
1.71
0.74
2.1
1.8
—
—
—
0
0
5
25
2.03
0.73
1.4
9.3
5.84
6.57
mmol/l
—
5
18
19
135
1.46
0.73
8.9
4.7
—
—
—
0
0
14
94
1.53
0.69
1.5
1.3
—
58.80
—
0
6
52
444
1.25
0.62
3.6
2.8
5.56
7.07
mmol/l
2.38
45
366
0
22
0.00
0.60
0.0
1.3
—
—
—
0
0
135
1409
0.78
0.56
4.8
4.8
5.69
5.94
mmol/l
1.33
129
1287
37
307
1.26
0.56
1.9
1.7
436.71
497.96
pmol/l
0.61
32
243
52
449
1.23
0.56
3.8
3.5
25.88
7.31
mg/mmol
0.72
33
259
6
39
1.56
0.53
1.0
1.3
—
—
—
0
0
130
1358
0.80
0.50
5.7
5.9
41.62
39.93
mmol/mol
0.31
125
1251
7
45
1.58
0.49
7.9
3.2
4.06
3.86
mmol/l
—
7
45
139
1440
0.79
0.47
5.0
5.2
2.61
2.77
mmol/l
1.10
131
1309
8
59
1.37
0.41
1.3
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
2.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
130
1349
0.83
0.39
4.3
4.2
1.19
1.25
mmol/l
0.57
121
1215
9
68
1.34
0.38
1.8
2.9
25.00
2092.99
u/ml
—
9
60
136
1405
0.82
0.38
4.7
4.6
4.52
4.75
mmol/l
1.70
129
1283
121
1155
1.18
0.37
5.0
4.3
15.31
14.92
pmol/l
0.97
114
1039
23
190
1.24
0.37
1.6
1.3
—
—
—
0
0
19
154
1.26
0.36
1.5
1.3
—
—
—
0
0
6
46
1.32
0.33
23.0
12.0
—
—
—
0
0
6
46
1.32
0.33
2.7
2.9
—
—
—
0
0
7
97
0.71
0.32
1.6
1.2
—
—
—
0
0
136
1397
0.85
0.28
4.6
4.6
1.56
1.57
mmol/l
0.09
127
1271
48
441
1.12
0.24
7.7
3.8
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
11.33
—
0
11
0
11
0.00
0.21
0.0
1.0
—
8.77
—
0
5
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.4
—
29.60
—
0
5
0
10
0.00
0.21
0.0
1.6
—
1.63
—
0
10
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
133
1355
0.91
0.15
6.6
5.2
2.07
1.93
mu/l
0.73
126
1229
20
183
1.11
0.10
1.1
1.2
—
—
—
0
0
12
133
0.89
0.08
2.1
1.7
—
—
—
0
0
7
83
0.84
0.07
2.1
1.5
—
—
—
0
0
36
345
1.06
0.06
1.4
1.3
—
—
—
0
0
148
1470
1.06
0.04
28.9
13.2
—
—
—
0
0
39
400
0.97
0.03
1.7
1.6
1.44
1.29
mmol/l
0.68
30
336
155
1551
0.99
0.00
53.8
21.4
128.77
133.22
g/l
3.64
155
1526
155
1551
0.99
0.00
54.1
21.2
39.31
39.84
%
0.56
138
1454
155
1551
0.99
0.00
53.0
21.3
4.39
4.43
e12/l
0.46
155
1507
155
1551
0.99
0.00
52.5
21.1
29.59
30.25
pg
4.21
155
1528
62
623
0.99
0.00
2.4
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
9.4
—
—
—
0
0
0
7
0.00
0.00
0.0
9.7
—
785.14
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
74.86
—
0
7
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
12.4
—
1370.57
—
0
7
155
1550
1.00
-0.00
53.0
21.3
7.00
6.54
e9/l
1.78
155
1508
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
76
0.92
-0.00
6.0
2.3
0.91
1.17
%
—
7
76
7
71
0.99
-0.00
3.6
3.7
—
—
—
0
0
155
1550
1.00
-0.00
52.7
21.2
90.79
91.24
fl
0.57
155
1527
0
8
0.00
-0.00
0.0
1.0
—
1.92
—
0
8
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.20
—
0
5
155
1550
1.00
-0.00
53.3
21.3
264.75
256.27
e9/l
0.76
155
1515
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
6.0
2.3
0.63
0.67
%
—
7
72
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
0.69
—
0
6
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
8.13
—
0
8

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: M13_PROGRESSIVE_SYSTEMIC_SCLEROSIS – Progressive systemic sclerosis

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).