Risteys · ARTHRO

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters None 0 out of 7 registries used, show all original rules.	0
4. Check minimum number of events None	0
5. Include endpoints M13_POSTRHEU M13_VILLONODULAR M13_PALINDROMIC M13_TRAUMARTHR M13_OTERSPECARTHR	829
6. Filter based on genotype QC (FinnGen only)	829

	All	Female	Male
Number of individuals
Whole population	5330	2986	2302
Only index persons	4747	2725	2022
Unadjusted period prevalence (%)
Whole population	0.08	0.09	0.06
Only index persons	0.09	0.10	0.08
Median age at first event (years)
Whole population	47.23	48.64	45.31
Only index persons	45.54	47.24	43.26

	All	Female	Male
Number of individuals	829	516	313
Unadjusted period prevalence (%)	0.16	0.18	0.14
Median age at first event (years)	47.73	46.63	49.53

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
767: Matched controls
7671

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

159.8

323.0

330

P01BA02

ATC

hydroxychloroquine; oral

153.5

323.0

347

M12.3

ICD-10 Finland

Palindromic rheumatism

+∞

323.0

322

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

969.5

227.5

212

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

62.5

224.0

259

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

68.2

193.1

220

A07EC01

ATC

sulfasalazine; oral, rectal

56.4

190.8

225

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

58.5

165.7

194

M12.2

ICD-10 Finland

Villonodular synovitis (pigmented)

+∞

156.8

145

M17.1

ICD-10 Finland

Other primary gonarthrosis

24.5

141.4

206

113

M13.9

ICD-10 Finland

Arthritis, unspecified

39.6

123.0

156

7192F

ICD-9 Finland

Other and unspecified disorder of joint, Villonodular synovitis[SYNOVITIS VILLONODULARIS, POLVI]

+∞

121.1

113

L88

ICPC

Rheumatoid/seropositive arthritis

182.7

120.2

123

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

117.8

104.2

111

NGB20

NOMESCO Finland

Primary total prosthetic replacement of knee joint without patellar part

+∞

103.5

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

106.9

102.1

110

H02AB06

ATC

prednisolone; systemic

4.7

88.8

493

2110

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

461.0

84.8

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

877.3

82.0

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

12.1

78.2

150

151

L04AA13

ATC

leflunomide; oral

288.9

78.0

M05.9

ICD-10 Finland

Seropositive rheumatoid arthritis, unspecified

791.3

74.5

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

+∞

68.8

M25.5

ICD-10 Finland

Pain in joint

4.1

61.9

314

1112

ND2DA

NOMESCO Finland

Bilateral hand X-ray examination

36.5

61.5

M17.0

ICD-10 Finland

Primary gonarthrosis, bilateral

12.9

60.6

111

1220

FHL

Arthroscopy

16.4

59.5

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

7.9

58.6

143

215

M12.8

ICD-10 Finland

Other specific arthropathies, not elsewhere classified

+∞

55.9

NH3DA

NOMESCO Finland

Bilateral foot X-ray examination

30.7

52.4

NGF15

NOMESCO Finland

Total synovectomy of knee, arthroscopic

76.7

50.8

M01CB01

ATC

sodium aurothiomalate; parenteral

508.7

48.9

NGF25

NOMESCO Finland

Operation for osteochondritis of knee, arthroscopic

11.1

48.6

NJ2MA

NOMESCO Finland

Measurement of mechanical axis of lower leg with X-ray

47.3

47.0

L04AB01

ATC

etanercept; parenteral

418.5

40.5

NGA30

NOMESCO Finland

Exploration of knee joint, arthroscopic

10.7

38.9

M12.0

ICD-10 Finland

Chronic postrheumatic arthropathy [Jaccoud]

+∞

38.9

NGR20

NOMESCO Finland

Intralesional or marginal excision of tumor of knee or lower leg

205.1

38.2

N02AX02

ATC

tramadol; systemic, rectal

2.7

35.6

356

1864

NG1CG

NOMESCO Finland

Knee and lower leg extensive MRI examination with high intensity magnet

20.3

35.3

WX320

NOMESCO Finland

Spinalanesthesy

3.4

34.2

193

688

M01AH05

ATC

etoricoxib; oral

2.6

34.2

487

3087

71220

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Palindromic rheumatism

+∞

33.6

1222

FHL

Arthroscopy and synovial surgery

66.5

33.3

M17.9

ICD-10 Finland

Gonarthrosis, unspecified

5.9

33.0

183

NGB40

NOMESCO Finland

Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis

+∞

32.5

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

2.7

32.4

290

1402

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

5.3

32.2

104

220

M16.1

ICD-10 Finland

Other primary coxarthrosis

16.3

32.1

L15

ICPC

Knee symptom/complaint

3.4

30.7

171

599

NFB30

NOMESCO Finland

Primary total prosthetic replacement of hip joint not using cement

111.2

29.9

M01AH01

ATC

celecoxib; oral (coxibs)

3.3

29.8

173

624

TNG10

NOMESCO Finland

Puncture of knee

155.9

28.8

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.4

28.3

375

2197

NGF35

NOMESCO Finland

Plastic operation of joint cartilage of knee

15.7

28.1

M01AE02

ATC

naproxen; oral, rectal

2.3

27.8

463

3026

M23.2

ICD-10 Finland

Derangement of meniscus due to old tear or injury

4.5

27.3

103

256

7140A

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]

+∞

27.2

M01CB03

ATC

auranofin; oral

+∞

27.2

ZX140

NOMESCO Finland

Intra articular

38.2

26.3

7151F

ICD-9 Finland

Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]

+∞

26.2

H02AB07

ATC

prednisone; oral

3.4

25.9

140

473

L04AB04

ATC

adalimumab; parenteral

31.3

25.2

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.3

25.2

337

1951

A02BC02

ATC

pantoprazole; systemic

2.2

24.3

504

3545

M13.0

ICD-10 Finland

Polyarthritis, unspecified

+∞

24.1

M05

ICD-10 Finland

Seropositive rheumatoid arthritis

+∞

24.1

NGF10

NOMESCO Finland

Total synovectomy of knee, open

+∞

24.1

M35.0

ICD-10 Finland

Sicca syndrome [Sjögren]

89.7

23.8

N02AJ06

ATC

codeine and paracetamol; systemic

2.3

23.1

293

1634

Z96.6

ICD-10 Finland

Presence of orthopaedic joint implants

123.7

22.7

M09AX01

ATC

hyaluronic acid; parenteral

9.2

22.4

M79.6

ICD-10 Finland

Pain in limb

2.3

22.0

278

1538

M35.9

ICD-10 Finland

Systemic involvement of connective tissue, unspecified

+∞

22.0

M17.3

ICD-10 Finland

Other post-traumatic gonarthrosis

39.9

21.8

M06.8

ICD-10 Finland

Other specified rheumatoid arthritis

226.2

21.7

M45

ICD-10 Finland

Ankylosing spondylitis

118.4

21.7

M01AC06

ATC

meloxicam; systemic, rectal

2.2

21.3

299

1731

M16.0

ICD-10 Finland

Primary coxarthrosis, bilateral

17.2

21.1

NF1AA

NOMESCO Finland

Hip X-ray examination

5.9

21.0

109

B01AB05

ATC

enoxaparin; parenteral

2.4

21.0

218

1093

M12.5

ICD-10 Finland

Traumatic arthropathy

+∞

20.9

D48.0

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage

13.4

20.8

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

79.0

20.8

M01AX05

ATC

glucosamine; oral

2.9

20.1

137

539

N03AX16

ATC

pregabalin; oral

2.4

19.8

190

911

M35.7

ICD-10 Finland

Hypermobility syndrome

205.0

19.6

M01AH02

ATC

rofecoxib; oral

3.0

19.4

120

443

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

12.6

19.2

H02AB04

ATC

methylprednisolone; systemic

2.8

18.2

130

524

M35.3

ICD-10 Finland

Polymyalgia rheumatica

12.8

18.2

NH3EA

NOMESCO Finland

Feet X-ray examination with load

11.8

18.1

NG1BG

NOMESCO Finland

Knee and lower leg MRI examination with high intensity magnet

6.5

18.0

9311

FHL

Knee cleansing surgery (synovectomy, debridement)

68.3

17.8

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

16.1

17.6

NH3BA

NOMESCO Finland

Foot and toes extensive X-ray examination

6.5

17.5

B01AF01

ATC

rivaroxaban; oral

3.7

17.4

236

L90

ICPC

Osteoarthrosis of knee

6.9

17.3

M79.0

ICD-10 Finland

Rheumatism, unspecified

6.8

17.1

N02BE01

ATC

paracetamol; systemic, rectal

2.3

17.1

644

5361

S18

ICPC

Laceration/cut

2.0

17.0

303

1894

L40.5

ICD-10 Finland

Arthropathic psoriasis

64.8

16.8

NG1AE

NOMESCO Finland

Knee joint ultrasound exmination

35.9

16.7

NG1DG

NOMESCO Finland

Knee and lower leg very extensive MRI examination with high intensity magnet

92.1

16.6

NG1DA

NOMESCO Finland

X-ray of knees

28.2

16.6

M01AB55

ATC

diclofenac, combinations; oral

3.9

16.3

185

SPAT1202

SPAT

Intra-articular injection

8.2

16.2

T84.0

ICD-10 Finland

Mechanical complication of internal joint prosthesis

25.1

16.1

M10.9

ICD-10 Finland

Gout, unspecified

6.9

16.0

M17.5

ICD-10 Finland

Other secondary gonarthrosis

61.3

15.8

WX111

NOMESCO Finland

Local infiltration anesthesia

61.3

15.8

L04AA17

ATC

[U] adalimumab; parenteral

+∞

15.7

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

+∞

15.7

M15.9

ICD-10 Finland

Polyarthrosis, unspecified

4.7

15.6

118

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

3.1

15.3

324

M01AX17

ATC

nimesulide; oral

2.2

15.3

190

1016

M13.1

ICD-10 Finland

Monoarthritis, not elsewhere classified

29.3

15.2

ZXA05

NOMESCO Finland

Left side

2.2

15.0

186

991

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

3.8

14.9

179

L20

ICPC

Joint symptom/complaint NOS

6.3

14.7

L04AA11

ATC

[U] etanercept; parenteral

+∞

14.6

NGD05

NOMESCO Finland

Partial excision of meniscus of knee, arthroscopic

3.1

14.5

295

M07.3

ICD-10 Finland

Other psoriatic arthropathies

152.8

14.5

L04AX01

ATC

azathioprine; systemic

5.4

14.3

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

2.5

14.1

123

552

71239

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD

54.4

13.9

1221

FHL

Arthroscopy and meniscus surgery

7.4

13.7

NK5AT

NOMESCO Finland

Joint injection with ultrasound guidance not elsewhere classified

76.5

13.6

L04AB06

ATC

golimumab; parenteral

76.5

13.6

J01DB01

ATC

cefalexin; oral

2.0

13.6

607

5059

TNG11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in knee

+∞

13.6

7164A

ICD-9 Finland

Other and unspecified arthropathies, Transient arthropathy

+∞

13.6

TND11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in joint, wrist or hand

34.7

13.5

M02.9

ICD-10 Finland

Reactive arthropathy, unspecified

21.6

13.4

ND2BA

NOMESCO Finland

Hand and fingers extensive X-ray examination

8.8

13.3

M19.0

ICD-10 Finland

Primary arthrosis of other joints

3.1

13.3

258

1225

FHL

Arthroscopy and other therapeutic procedure

14.1

13.3

M23.8

ICD-10 Finland

Other internal derangements of knee

5.6

13.2

N02AA05

ATC

oxycodone; systemic

2.6

13.2

102

430

M75.1

ICD-10 Finland

Rotator cuff syndrome

2.1

13.1

171

926

ZXA00

NOMESCO Finland

Right side

2.0

13.0

190

1074

M01AE03

ATC

ketoprofen; systemic, rectal

1.8

13.0

287

1890

M02AA07

ATC

piroxicam; topical

1.9

13.0

262

1672

M23.9

ICD-10 Finland

Internal derangement of knee, unspecified

3.1

13.0

257

L04AA01

ATC

[U] ciclosporin; systemic

11.8

12.9

71238

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita

71.1

12.6

NDG30

NOMESCO Finland

Fusion of wrist, total

+∞

12.5

71320

ICD-8 Finland

Osteo-arthritis and allied conditions, Traumatic spondylopathy

+∞

12.5

TNH11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in ankle joint or foot joint

132.1

12.5

SPAT1223

SPAT

Implementation of physical therapy rehabilitation plan

2.0

12.5

198

1158

M17

ICD-10 Finland

Gonarthrosis [arthrosis of knee]

3.4

12.3

192

M01AB05

ATC

diclofenac; systemic, rectal

1.7

12.2

491

3867

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.0

12.2

257

M16.9

ICD-10 Finland

Coxarthrosis, unspecified

5.9

12.1

NB1AA

NOMESCO Finland

Shoulder X-ray examination without contrast

3.6

12.0

158

M13.8

ICD-10 Finland

Other specified arthritis

16.7

11.7

XX9XE

NOMESCO Finland

Other ultrasound examination

30.5

11.7

M06

ICD-10 Finland

Other rheumatoid arthritis

66.0

11.6

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.8

11.6

274

1825

J01AA02

ATC

doxycycline; systemic

1.8

11.5

583

4883

7148X

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies

121.8

11.5

N02AC04

ATC

dextropropoxyphene; oral

4.9

11.3

M00.9

ICD-10 Finland

Pyogenic arthritis, unspecified

17.4

11.2

NA1EA

NOMESCO Finland

Cervical spine X-ray examination with flexion

11.4

11.1

T84.5

ICD-10 Finland

Infection and inflammatory reaction due to internal joint prosthesis

44.0

10.9

NG2AA

NOMESCO Finland

Patella X-ray examination

12.1

10.9

M02AA10

ATC

ketoprofen; topical

2.2

10.8

118

587

X59

ICD-10 Finland

Exposure to unspecified factor

2.1

10.7

130

680

NE1AA

NOMESCO Finland

Pelvis X-ray examination

4.0

10.6

110

A02BA02

ATC

ranitidine; systemic

2.0

10.6

143

779

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

3.3

10.4

171

TNX32

NOMESCO Finland

Custom moulded splint, unspecified region

3.6

10.4

133

G56.0

ICD-10 Finland

Carpal tunnel syndrome

2.3

10.4

102

483

SPAT1153

SPAT

Removal of sutures

1.8

10.4

218

1392

7177A

ICD-9 Finland

Internal derangement of knee, Chondromalacia of patella

9.0

10.3

A02BC03

ATC

lansoprazole; oral

1.8

10.3

207

1300

FM1EE

NOMESCO Finland

Extensive structural and functional ultrasound examination of heart

2.0

10.3

147

817

L03

ICPC

Low back symptom/complaint

1.9

10.2

169

991

J45.9

ICD-10 Finland

Asthma, unspecified

2.1

10.1

128

680

NDL52

NOMESCO Finland

Tenosynovectomy of hand

40.6

10.0

M10.0

ICD-10 Finland

Idiopathic gout

7.8

9.9

M79.7

ICD-10 Finland

Fibromyalgia

6.1

9.9

A46

ICD-10 Finland

Erysipelas

2.2

9.8

477

NC1AA

NOMESCO Finland

Elbow X-ray examination without contrast

5.2

9.8

M25.4

ICD-10 Finland

Effusion of joint

13.6

9.7

M01AB01

ATC

indometacin; systemic, rectal

3.0

9.7

191

R06.0

ICD-10 Finland

Dyspnoea

1.9

9.6

171

1029

SPAT1263

SPAT

Sampling

1.7

9.5

289

2046

L28

ICPC

Limited function/disability (L)

2.2

9.5

484

L04AC07

ATC

tocilizumab; parenteral

+∞

9.4

J01FA10

ATC

azithromycin; systemic

1.6

9.3

413

3229

A02BC05

ATC

esomeprazole; systemic

1.6

9.3

287

2042

NE1CG

NOMESCO Finland

Pelvic, hip and femur extensive MRI examination with high intensity magnet

7.4

9.3

J01DA09

ATC

[U] cefadroxil; inhalant, oral

1.7

9.1

201

1294

NHM20

NOMESCO Finland

Excision of synovial ganglion of ankle or foot

9.2

9.1

WZA10

NOMESCO Finland

Long statement of health and health related matters

9.2

9.1

N03AX12

ATC

gabapentin; oral

2.1

9.0

104

532

Y83

ICD-10 Finland

Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

2.9

8.9

201

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.0

8.9

128

712

J01FF01

ATC

clindamycin; systemic

1.8

8.9

189

1202

7890A

ICD-9 Finland

Other symptoms involving abdomen and pelvis, Abdominal pain

2.9

8.8

187

NHG77

NOMESCO Finland

Arthroplasty of interphalangeal tarsal joint(s)

7.3

8.8

M04AA01

ATC

allopurinol; systemic

2.4

8.8

324

M03BX02

ATC

tizanidine; oral

1.6

8.6

449

3622

M05BA04

ATC

alendronic acid; oral

2.6

8.6

243

M46.1

ICD-10 Finland

Sacroiliitis, not elsewhere classified

20.3

8.5

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.0

8.5

121

669

M03BA52

ATC

carisoprodol, combinations excl. psycholeptics; oral

3.7

8.4

H02AB08

ATC

triamcinolone; systemic

91.0

8.4

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

1.6

8.4

243

1688

WX204

NOMESCO Finland

Axillary plexus blockaced

4.4

8.4

SPAT1149

SPAT

Suture or treatment of traumatic wound

2.2

8.4

438

NB1AE

NOMESCO Finland

Shoulder ultrasound examination

6.3

8.4

L04AA24

ATC

abatacept; parenteral

+∞

8.3

NGC00

NOMESCO Finland

Exchange of a loose part of prosthesis in knee joint

+∞

8.3

212

Kela drug reimbursment

Gout

+∞

8.3

9522

FHL

Synovectomy

+∞

8.3

NGC20

NOMESCO Finland

Secondary implantation of prosthesis in knee joint, normal prosthesis

+∞

8.3

M15.0

ICD-10 Finland

Primary generalized (osteo)arthrosis

5.9

8.3

M19.1

ICD-10 Finland

Post-traumatic arthrosis of other joints

4.9

8.3

L99

ICPC

Musculoskeletal disease other

7.2

8.3

Z01.8

ICD-10 Finland

Other specified special examinations

1.8

8.3

147

880

SPAT1216

SPAT

Assessment of functional ability

2.1

8.2

515

L13

ICPC

Hip symptom/complaint

2.2

8.2

435

J01MA01

ATC

ofloxacin; systemic

2.4

8.1

310

R06AE07

ATC

cetirizine; oral

1.6

8.1

300

2216

NJ3NA

NOMESCO Finland

Measurement of difference in extremity lengty with X-ray

33.7

8.1

NH1CG

NOMESCO Finland

Ankle and foot extensive MRI examination with high intensity magnet

10.2

8.1

NFB40

NOMESCO Finland

Primary total prosthetic replacement of hip joint using hybrid technique

22.3

8.0

TQW40

NOMESCO Finland

Remowal of suture of skin

2.5

8.0

243

M15.8

ICD-10 Finland

Other polyarthrosis

7.3

8.0

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

1.6

7.9

226

1560

R52.9

ICD-10 Finland

Pain, unspecified

2.5

7.8

252

M01AH03

ATC

valdecoxib; oral

2.6

7.8

215

SPAT1222

SPAT

Counselling/guidance promoting independent living

2.0

7.8

510

NHG24

NOMESCO Finland

Fusion of subtalar joint and between bones of ankle

45.4

7.7

B01AX06

ATC

[U] rivaroxaban; oral

45.4

7.7

NH3FA

NOMESCO Finland

Weight-bearing X-ray of foot

6.3

7.6

R01BA52

ATC

pseudoephedrine, combinations; oral

1.6

7.6

223

1545

NHG76

NOMESCO Finland

Arthroplasty of other tarsometatarsal joint

10.2

7.6

M01AE01

ATC

ibuprofen; systemic, rectal

1.8

7.5

656

5915

R03AK07

ATC

formoterol and budesonide; inhalant

1.8

7.5

142

865

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.5

7.5

353

2745

R51.80

ICD-10 Finland

Headache

2.0

7.4

520

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.8

7.4

151

940

N06AA09

ATC

amitriptyline; systemic

2.2

7.4

368

M32.9

ICD-10 Finland

Systemic lupus erythematosus, unspecified

80.8

7.4

NF2AT

NOMESCO Finland

Injection to hip joint with ultrasound guidance

80.8

7.4

ZSN00

NOMESCO Finland

Procedure related to previous procedure classified in chapter N

13.5

7.4

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

2.5

7.4

239

J01FA06

ATC

roxithromycin; oral

1.6

7.4

283

2096

UJF32

NOMESCO Finland

Coloscopy

1.7

7.4

170

1103

9256

FHL

Synovectomy (knee 9311)

+∞

7.3

J01DA01

ATC

[U] cefalexin; systemic

1.5

7.3

437

3581

R03AC02

ATC

salbutamol; inhalant

1.5

7.2

364

2864

P01BA01

ATC

chloroquine; systemic

15.9

7.2

ZZH31

NOMESCO Finland

Bone allograft, small pieces

30.3

7.2

L12

ICPC

Hand/finger symptom/complaint

2.0

7.1

514

7170A

ICD-9 Finland

Internal derangement of knee, Old bucket handle tear of medial meniscus

6.7

7.1

Z50.1

ICD-10 Finland

Other physical therapy

2.9

7.1

145

NH1BG

NOMESCO Finland

Ankle and foot MRI examination with high intensity magnet

5.7

7.1

M01AE11

ATC

tiaprofenic acid; oral, rectal

3.5

7.1

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

3.6

7.1

L17

ICPC

Foot/toe symptom/complaint

1.7

7.0

162

1050

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

1.6

6.9

183

1231

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.3

6.9

269

NGE10

NOMESCO Finland

Incision or suture of capsule of knee joint

13.9

6.9

C03CA01

ATC

furosemide; systemic

1.7

6.9

164

1070

NDU20

NOMESCO Finland

Removal of internal fixation device from wrist or hand

4.4

6.9

WX408

NOMESCO Finland

General anesthesy, balanced

1.6

6.9

181

1214

M01AG01

ATC

mefenamic acid; oral

4.2

6.9

M65.9

ICD-10 Finland

Synovitis and tenosynovitis, unspecified

4.2

6.9

M01AC01

ATC

piroxicam; systemic, rectal

1.9

6.8

514

9243

FHL

Plastic of the patella and its tendons

11.1

6.8

ZZH21

NOMESCO Finland

Graft of patients own bone, small pieces

6.2

6.8

M87.0

ICD-10 Finland

Idiopathic aseptic necrosis of bone

40.4

6.8

ND2BG

NOMESCO Finland

MRI of hand

40.4

6.8

M01AX01

ATC

nabumetone; oral

3.1

6.8

117

B01AX05

ATC

fondaparinux; parenteral

16.9

6.8

R52.2

ICD-10 Finland

Other chronic pain

3.7

6.6

D16.2

ICD-10 Finland

Benign neoplasm: Long bones of lower limb

12.4

6.6

WZB00

NOMESCO Finland

Telephone receipt or other advice

1.6

6.6

192

1324

P01AB01

ATC

metronidazole; oral, rectal

1.5

6.6

273

2047

ZX120

NOMESCO Finland

Intravenous

2.2

6.6

319

G47.3

ICD-10 Finland

Sleep apnoea

1.7

6.5

137

860

E66.01

ICD-10 Finland

Obesity due to excess calories

2.4

6.5

231

M25.0

ICD-10 Finland

Haemarthrosis

10.1

6.5

M22.4

ICD-10 Finland

Chondromalacia patellae

3.9

6.5

L01

ICPC

Neck symptom/complaint

1.9

6.5

509

M54.5

ICD-10 Finland

Low back pain

1.6

6.5

211

1494

H02BX01

ATC

methylprednisolone, combinations; systemic

2.8

6.5

144

Z71.2

ICD-10 Finland

Person consulting for explanation of investigation findings

1.7

6.5

153

997

S83.6

ICD-10 Finland

Sprain and strain of other and unspecified parts of knee

2.9

6.5

131

NCF20

NOMESCO Finland

Operation for osteochondritis of elbow joint, open

70.4

6.4

NF1DA

NOMESCO Finland

X-ray of hips

14.4

6.4

M48.0

ICD-10 Finland

Spinal stenosis

2.1

6.4

344

2402

FHL

External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)

6.6

6.4

M47.80

ICD-10 Finland

Other spondylosis, multiple sites in spine

3.7

6.3

M75.4

ICD-10 Finland

Impingement syndrome of shoulder

2.3

6.3

254

R03AK06

ATC

salmeterol and fluticasone; inhalant

1.9

6.3

500

9531

FHL

Arthrodesis of the hand joint

18.2

6.3

SPAT1229

SPAT

Assessment of need for aid

2.3

6.3

235

NGC60

NOMESCO Finland

Exchange or addition of patellar part

+∞

6.3

NGU00

NOMESCO Finland

Removal of partial prosthesis from knee joint, other or unspecified

+∞

6.3

293

Kela drug reimbursment

Baricitinib

+∞

6.3

NGC30

NOMESCO Finland

Secondary implantation of prosthesis in knee joint, special prosthesis

+∞

6.3

3006

Kela drug reimbursment

Baricitinib

+∞

6.3

L01CB

ATC

Podophyllotoxin derivatives

+∞

6.3

71250

ICD-8 Finland

Rheumatoid arthritis and allied conditions, Chronic rheumatoid nodular fibrositis

+∞

6.3

7140B

ICD-9 Finland

Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]

+∞

6.3

9503

FHL

Tendon or tendon sheath cleansing surgery (tenosynovectomy)

+∞

6.3

291

Kela drug reimbursment

Tofacitinib

+∞

6.3

7118F

ICD-9 Finland

Arthropathy associated with infections, Arthropathy associated with other infectious and parasitic diseases[ARTHRITIS POSTINFECTIOSA ALIA, POLVI]

+∞

6.3

L04AB05

ATC

certolizumab pegol; parenteral

+∞

6.3

TND10

NOMESCO Finland

Joint puncture, wrist or finger joint

+∞

6.3

NDG79

NOMESCO Finland

Other excision, reconstruction or fusion of joint of II-V finger

+∞

6.3

D48.1

ICD-10 Finland

Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue

4.5

6.2

WX002

NOMESCO Finland

Sedation and analgesia

1.8

6.2

115

699

J01MA02

ATC

ciprofloxacin; systemic

1.5

6.1

251

1870

M67.4

ICD-10 Finland

Ganglion

2.4

6.1

200

M67.8

ICD-10 Finland

Other specified disorders of synovium and tendon

8.7

6.1

R05FB02

ATC

cough suppressants and expectorants

1.5

6.1

260

1954

1XC02

NOMESCO Finland

10.1

6.0

J01MA12

ATC

levofloxacin; systemic

1.7

6.0

120

741

WX110

NOMESCO Finland

Local anesthesy

1.5

6.0

470

3988

NAME	ARTHRO_SPEC
CONTROL_EXCLUDE	RHEUMA_ENDPOINTS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	M13_POSTRHEU\|M13_VILLONODULAR\|M13_PALINDROMIC\|M13_TRAUMARTHR\|M13_OTERSPECARTHR
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Parameter	HR [95% CI]	p-value
ARTHRO_SPEC	1.041 [0.88, 1.23]	0.631
Birth year	0.997 [0.99, 1.01]	0.483

Parameter	HR [95% CI]	p-value
ARTHRO_SPEC	1.271 [1.08, 1.5]	0.005
Birth year	0.989 [0.98, 1.0]	0.031

N-year risk	Females	Males
1	0.123%	0.28%
5	0.608%	1.685%
10	1.514%	4.008%
15	3.05%	7.209%
20	5.688%	12.403%

Other specific arthropathies, wide

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints