pigmented villonodular synovitis: Pigmented villonodular synovitis (PVNS) is a rare benign proliferative disorder of the synovial membrane primarily affecting young adults (with a peak age of onset in the second to fourth decade of life) characterized by proliferative, locally invasive tumor-like lesions, usually involving a single joint, tendon sheath or bursae (most commonly the joints of the knee and hip and rarely others such as the ankle, shoulder and temporomandibular joints). It presents with pain and limitation of motion along with swelling, heat and tenderness over the involved joint, eventually leading to arthritic degeneration and significant locomotor deficit, if left untreated. PVNS can recur in patients even after treatment.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
306 |
4. Check minimum number of eventsNone |
306 |
5. Include endpointsNone |
306 |
6. Filter based on genotype QC (FinnGen only) |
297 |
Control definitions (FinnGen only)
- Control exclude
- M13_ARTHROPATHIES
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- M12
- Name in latin
- Synovitis villonodularis [pigmentata]
Similar endpoints
↥List of similar endpoints to
Villonodular synovitis (pigmented)
based on the number of shared cases.
Similar with more cases:
- Other specific arthropathies, wide
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2060 | 1083 | 962 |
| Only index persons | 1901 | 1014 | 887 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 39.12 | 40.66 | 37.21 |
| Only index persons | 38.21 | 39.93 | 36.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 297 | 186 | 111 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 40.31 | 41.06 | 39.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 306
- Matched controls
- 3060
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M12.2
ICD-10 Finland
Villonodular synovitis (pigmented)
+∞
192.7
164
*
1220
FHL
Arthroscopy
82.3
155.2
84
14
M17.1
ICD-10 Finland
Other primary gonarthrosis
37.0
154.7
104
42
7192F
ICD-9 Finland
Other and unspecified disorder of joint, Villonodular synovitis[SYNOVITIS VILLONODULARIS, POLVI]
+∞
142.1
125
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
26.4
117.3
88
46
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
66.8
98.7
55
10
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
40.1
89.2
56
17
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
43.5
88.1
54
15
A07EC01
ATC
sulfasalazine; oral, rectal
22.9
86.2
67
37
M13.9
ICD-10 Finland
Arthritis, unspecified
30.3
80.2
55
22
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
52.6
77.1
45
10
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
15.4
76.6
74
62
P01BA02
ATC
hydroxychloroquine; oral
27.1
75.6
54
24
L04AX03
ATC
methotrexate; systemic
17.7
72.9
64
45
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
174.3
56.0
57
*
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
16.1
53.1
48
35
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
77.4
51.3
57
9
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
48.2
45
*
WX320
NOMESCO Finland
Spinalanesthesy
6.1
47.7
109
253
M25.5
ICD-10 Finland
Pain in joint
5.5
46.8
137
395
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
249.1
43.1
43
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
13.4
42.1
42
36
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
235.7
40.9
41
*
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
63.9
38.5
44
8
M19.0
ICD-10 Finland
Primary arthrosis of other joints
13.9
37.3
36
29
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
402.3
36.8
36
*
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
8.5
36.3
51
70
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
389.6
35.7
35
*
1222
FHL
Arthroscopy and synovial surgery
376.9
34.7
34
*
L01BA01
ATC
methotrexate; systemic
98.5
32.5
35
*
L88
ICPC
Rheumatoid/seropositive arthritis
67.6
31.8
36
6
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
+∞
29.7
28
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
9.8
28.6
35
40
L15
ICPC
Knee symptom/complaint
4.3
27.0
90
273
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
6.6
26.2
46
80
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
147.5
26.0
27
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
28.3
24.5
33
13
NGF10
NOMESCO Finland
Total synovectomy of knee, open
+∞
23.2
22
*
9311
FHL
Knee cleansing surgery (synovectomy, debridement)
+∞
22.1
21
*
1221
FHL
Arthroscopy and meniscus surgery
123.9
21.9
23
*
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
123.9
21.9
23
*
ZXD10
NOMESCO Finland
Scheduled procedure
3.1
21.3
146
690
1225
FHL
Arthroscopy and other therapeutic procedure
118.1
20.8
22
*
M01AH01
ATC
celecoxib; oral
4.0
19.5
66
199
L04AA13
ATC
[U] leflunomide
106.7
18.8
20
*
ZXA00
NOMESCO Finland
Right side
3.2
18.3
93
364
M01AX05
ATC
glucosamine; oral
4.2
18.1
54
148
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
5.4
18.1
38
78
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
17.9
17
*
M01AH05
ATC
etoricoxib; oral
3.0
17.7
209
1287
B01AB05
ATC
enoxaparin; parenteral
3.1
17.6
102
430
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
+∞
16.8
16
*
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
16.8
16
*
N02AX02
ATC
tramadol; systemic, rectal
2.8
16.8
144
746
M23.8
ICD-10 Finland
Other internal derangements of knee
29.5
16.7
22
8
M01AH02
ATC
rofecoxib; oral
3.9
16.1
52
151
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
+∞
15.8
15
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.7
15.6
129
650
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
30.4
15.4
20
7
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
15.4
145
779
ZXA05
NOMESCO Finland
Left side
3.1
15.3
81
322
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
84.2
14.7
16
*
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
84.2
14.7
16
*
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
+∞
14.7
14
*
WX111
NOMESCO Finland
Local infiltration anesthesia
+∞
14.7
14
*
H02AB06
ATC
prednisolone; systemic
2.5
14.2
152
858
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
31.7
14.0
18
6
B01AF01
ATC
rivaroxaban; oral
4.3
13.7
38
98
M09AX01
ATC
hyaluronic acid; parenteral
17.2
13.7
21
13
TNG10
NOMESCO Finland
Puncture of knee
+∞
13.6
13
*
M01CB01
ATC
sodium aurothiomalate; parenteral
+∞
13.6
13
*
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
4.5
12.9
33
80
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
12.8
138
772
M22.4
ICD-10 Finland
Chondromalacia patellae
33.6
12.7
16
5
NHG80
NOMESCO Finland
Fusion of first tarsometatarsal joint
+∞
12.6
12
*
M17.5
ICD-10 Finland
Other secondary gonarthrosis
135.3
12.5
13
*
M25.4
ICD-10 Finland
Effusion of joint
48.7
12.0
14
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
124.5
11.5
12
*
A02BC02
ATC
pantoprazole; systemic
2.4
11.5
210
1456
L90
ICPC
Osteoarthrosis of knee
11.2
11.5
21
20
M16.1
ICD-10 Finland
Other primary coxarthrosis
13.4
11.3
19
15
Z3226
NOMESCO Finland
Physiotherapist
2.9
11.1
59
232
M01AE02
ATC
naproxen; oral, rectal
2.3
10.8
183
1215
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
62.2
10.7
12
*
S18
ICPC
Laceration/cut
2.2
10.6
140
839
M01AC06
ATC
meloxicam; systemic, rectal
2.3
10.5
112
614
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
+∞
10.5
10
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
4.2
10.4
29
75
N03AX16
ATC
[U] pregabalin
2.5
10.3
75
346
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
41.5
10.0
12
*
M01AE11
ATC
tiaprofenic acid; oral, rectal
9.2
9.9
20
23
X59
ICD-10 Finland
Exposure to unspecified factor
2.6
9.9
64
278
TQW40
NOMESCO Finland
Remowal of suture of skin
4.0
9.9
29
78
M79.6
ICD-10 Finland
Pain in limb
2.2
9.8
126
741
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
56.8
9.7
11
*
J01AA02
ATC
doxycycline; systemic
2.5
9.7
245
1882
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
5.1
9.7
21
44
R4110
NOMESCO Finland
Physiotherapy
2.3
9.6
89
456
M01AX17
ATC
nimesulide; oral
2.5
9.5
71
330
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
12.9
9.5
16
13
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
103.1
9.5
10
*
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
22.5
9.4
13
6
M19.2
ICD-10 Finland
Other secondary arthrosis
+∞
9.4
9
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
9.2
133
815
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
9.9
8.9
17
18
H02AB04
ATC
methylprednisolone; systemic
2.8
8.7
48
192
M01AC01
ATC
piroxicam; systemic, rectal
2.8
8.6
45
175
ND1CG
NOMESCO Finland
Wrist and hand extensive MRI examination with high intensity magnet
28.4
8.5
11
*
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
28.4
8.5
11
*
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
20.7
8.5
12
6
M24.2
ICD-10 Finland
Disorder of ligament
92.5
8.5
9
*
SPAT1202
SPAT
Intra-articular injection
13.3
8.5
14
11
M01AE03
ATC
ketoprofen; systemic, rectal
2.1
8.4
110
644
N02BE01
ATC
paracetamol; systemic, rectal
2.9
8.4
273
2259
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
+∞
8.4
8
*
M25.0
ICD-10 Finland
Haemarthrosis
+∞
8.4
8
*
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
+∞
8.4
8
*
72410
ICD-8 Finland
Internal derangement of joint, Other shoulder derangement
+∞
8.4
8
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
+∞
8.4
8
*
ZX140
NOMESCO Finland
Intra articular
+∞
8.4
8
*
M02AA07
ATC
piroxicam; topical
2.1
8.3
108
631
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.4
8.2
31
99
M01AB05
ATC
diclofenac; systemic, rectal
2.1
8.2
204
1503
ZXE00
NOMESCO Finland
One hour or less
2.1
8.1
118
716
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
34.3
8.1
10
*
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
4.2
8.0
22
56
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
18.9
7.7
11
6
NG2AA
NOMESCO Finland
Patella X-ray examination
25.7
7.6
10
*
ZXD20
NOMESCO Finland
Day surgery
2.7
7.4
42
170
L04AA17
ATC
[U] adalimumab
+∞
7.3
7
*
7190F
ICD-9 Finland
Other and unspecified disorder of joint, Effusion of joint[HYDROPS (HYDRARTHRON), POLVI]
+∞
7.3
7
*
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
+∞
7.3
7
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
7.3
46
196
L04AB04
ATC
adalimumab; parenteral
16.2
7.3
11
7
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.5
7.3
25
75
TNX50
NOMESCO Finland
Removal of cutom molded cast and internal stretch
4.7
7.3
17
38
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
9.1
7.1
14
16
TQW40, ,
SPAT
3.5
7.0
24
72
S83.2
ICD-10 Finland
Tear of meniscus, current
4.0
6.9
20
53
M01AH03
ATC
valdecoxib; oral
3.8
6.9
21
58
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
17.2
6.8
10
6
L40.5
ICD-10 Finland
Arthropathic psoriasis
41.0
6.8
8
*
N03AX12
ATC
[U] gabapentin; oral
2.5
6.7
46
204
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.2
6.6
66
344
J01FF01
ATC
clindamycin; systemic
2.0
6.6
84
480
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
6.6
75
411
M20.1
ICD-10 Finland
Hallux valgus (acquired)
9.0
6.6
13
15
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
7.7
6.5
14
19
WX002
NOMESCO Finland
Sedation and analgesia
2.3
6.5
52
248
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
71.3
6.4
7
*
1223
FHL
Arthroscopy and articular cartilage surgery
71.3
6.4
7
*
M23.3
ICD-10 Finland
Other meniscus derangements
71.3
6.4
7
*
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
71.3
6.4
7
*
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
6.8
6.4
15
23
NF1AA
NOMESCO Finland
Hip X-ray examination
3.7
6.3
20
57
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
+∞
6.3
6
*
L04AB01
ATC
etanercept; parenteral
+∞
6.3
6
*
M13.0
ICD-10 Finland
Polyarthritis, unspecified
+∞
6.3
6
*
M07.3
ICD-10 Finland
Other psoriatic arthropathies
+∞
6.3
6
*
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
+∞
6.3
6
*
NHK40
NOMESCO Finland
Osteotomy or rotation osteotomy of II-V metatarsal or tarsal bone
+∞
6.3
6
*
7174A
ICD-9 Finland
Internal derangement of knee, Derangement of lateral meniscus
+∞
6.3
6
*
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
+∞
6.3
6
*
L04AA11
ATC
[U] etanercept
+∞
6.3
6
*
9243
FHL
Plastic of the patella and its tendons
27.3
6.3
8
*
SPAT1153
SPAT
Removal of sutures
2.0
6.1
86
509
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
37
14
29.83
27.82
1.5
1.0
—
—
—
0
0
79
287
3.36
17.52
1.3
1.1
5.90
1.41
u/ml
0.74
31
131
76
314
2.89
13.20
1.3
1.1
73.26
17.78
iu/ml
0.67
29
98
229
1644
2.56
11.68
5.7
3.0
10.26
10.30
mm/h
0.02
220
1507
189
1335
2.09
8.75
11.6
9.6
3.70
4.07
e9/l
1.58
168
1151
20
53
3.97
6.92
1.5
1.5
0.00
0.05
iu/ml
—
5
10
279
2395
2.87
6.83
14.7
11.7
17.66
23.99
mg/l
3.58
226
1771
223
1760
1.98
6.57
8.7
7.2
73.93
77.42
u/l
0.83
212
1656
131
906
1.78
5.59
2.3
2.2
73.19
73.92
nmol/l
0.12
120
827
23
81
2.99
5.21
1.8
1.9
—
—
—
0
0
134
970
1.68
4.63
2.4
2.6
—
—
—
0
0
78
494
1.78
4.33
2.3
2.3
—
—
—
0
0
10
18
5.70
4.01
2.0
1.2
—
—
—
0
0
20
77
2.71
3.89
1.9
1.7
—
—
—
0
0
75
488
1.71
3.75
1.4
1.6
1.36
1.09
mg/l
0.25
51
363
134
1015
1.57
3.62
5.2
7.9
1.22
1.22
mmol/l
0.01
121
870
277
2514
2.07
3.54
14.0
13.4
139.89
139.70
mmol/l
0.64
271
2449
54
328
1.78
3.41
1.6
1.9
—
—
—
0
0
277
2522
2.04
3.38
14.0
13.5
3.95
3.95
mmol/l
0.06
268
2454
265
2387
1.82
3.22
12.2
10.4
85.72
84.87
ml/min/173m2
0.29
218
1946
252
2247
1.69
3.07
4.9
4.4
1.85
2.42
mu/l
0.54
241
2065
99
738
1.50
2.73
2.7
3.8
2.37
2.36
mmol/l
0.07
92
665
6
10
6.09
2.71
5.8
3.2
40466.67
37650.00
ug/l
—
6
10
118
916
1.47
2.65
4.5
6.8
1.22
1.22
mmol/l
0.04
110
851
7
15
4.75
2.61
1.1
1.1
—
—
—
0
0
105
803
1.47
2.52
1.8
1.9
94.76
97.05
pmol/l
0.18
63
423
287
2700
2.01
2.34
13.8
8.7
26.53
27.15
u/l
0.32
281
2619
196
1700
1.43
2.29
2.8
3.1
—
—
—
0
0
134
1088
1.41
2.28
3.8
3.2
0.00
0.00
estimate
-0.00
11
196
14
60
2.40
2.25
1.1
1.3
—
—
—
0
0
5
9
5.63
2.22
2.8
1.9
—
—
—
0
0
115
916
1.41
2.16
4.2
5.0
36.95
36.16
g/l
0.98
110
863
6
14
4.35
2.16
1.0
2.3
—
14.46
—
0
5
96
741
1.43
2.15
3.1
2.9
—
—
—
0
0
116
930
1.40
2.09
11.8
10.3
1.28
1.20
inr
0.29
28
304
18
91
2.04
1.99
1.1
1.3
306.55
220.25
miu/ml
0.37
11
40
133
1099
1.37
1.97
3.8
3.2
0.00
0.03
estimate
0.80
11
185
73
547
1.44
1.90
3.0
2.7
0.24
0.59
e6/l
1.32
58
388
60
433
1.48
1.89
1.7
1.4
—
—
—
0
0
132
1095
1.36
1.89
5.3
4.4
0.00
0.01
estimate
—
10
189
5
12
4.22
1.83
1.0
1.0
—
—
—
0
0
248
2282
1.46
1.82
5.0
4.9
38.29
39.42
mmol/mol
1.30
239
2137
13
60
2.22
1.80
1.3
1.6
—
—
—
0
0
39
260
1.57
1.77
1.3
1.8
—
—
—
0
0
140
1184
1.34
1.73
6.0
6.9
9.86
11.62
umol/l
1.66
129
1137
47
333
1.49
1.63
3.0
2.5
0.86
1.04
e6/l
0.31
27
171
78
613
1.37
1.53
1.9
2.1
302.96
186.36
u/l
0.58
73
584
11
51
2.20
1.52
1.6
1.2
—
—
—
0
0
7
28
2.53
1.46
1.9
1.5
—
—
—
0
0
7
28
2.53
1.46
1.9
1.5
—
—
—
0
0
7
28
2.53
1.46
1.9
1.5
—
—
—
0
0
68
527
1.37
1.46
2.7
3.3
601.71
1126.86
ng/l
2.47
58
444
5
16
3.16
1.44
2.8
3.6
—
—
—
0
0
54
403
1.41
1.44
2.8
3.8
35.87
392.55
ng/l
1.39
38
286
38
265
1.50
1.43
3.6
3.8
32.28
32.04
%
0.05
32
184
7
29
2.45
1.40
1.9
1.4
—
—
—
0
0
7
29
2.45
1.40
1.9
1.4
—
—
—
0
0
7
29
2.45
1.40
1.9
1.4
—
—
—
0
0
42
301
1.46
1.39
1.5
2.0
—
—
—
0
0
146
1271
1.28
1.37
3.7
5.1
6.67
6.67
mmol/l
0.01
140
1183
11
54
2.08
1.34
1.3
1.0
—
—
—
0
0
293
2830
1.83
1.33
22.6
17.0
254.90
253.33
e9/l
0.15
288
2755
206
1878
1.30
1.32
4.3
3.8
14.45
14.63
pmol/l
0.50
198
1732
20
122
1.68
1.31
1.2
1.3
—
53.14
—
0
10
293
2832
1.81
1.30
22.7
17.0
4.55
4.55
e12/l
0.07
287
2758
9
44
2.08
1.28
1.9
1.5
—
—
—
0
0
293
2834
1.80
1.26
22.8
17.0
136.94
137.08
g/l
0.07
293
2789
266
2526
1.41
1.20
4.4
4.0
4.80
4.79
mmol/l
0.06
255
2368
292
2828
1.71
1.15
22.6
17.1
40.89
40.78
%
0.14
283
2658
0
36
0.00
1.14
0.0
2.1
—
12.93
—
0
36
7
32
2.21
1.08
1.3
1.6
—
—
—
0
0
24
162
1.52
1.08
1.9
2.3
13.49
13.87
nmol/l
0.10
24
147
30
213
1.45
1.07
2.0
2.3
34.72
41.62
u/l
0.35
25
179
264
2516
1.36
1.05
4.3
3.9
1.42
1.48
mmol/l
1.52
252
2345
11
60
1.86
1.04
1.8
1.7
—
—
—
0
0
5
22
2.29
1.04
1.4
1.9
—
—
—
0
0
13
76
1.74
1.00
1.1
1.6
—
—
—
0
0
9
49
1.86
0.99
1.2
1.6
—
—
—
0
0
21
141
1.53
0.98
2.1
2.3
—
20.92
—
0
9
68
559
1.28
0.98
1.2
1.3
0.59
1.97
u/ml
1.07
13
152
31
227
1.41
0.95
1.4
2.0
—
—
—
0
0
7
37
1.91
0.94
1.3
1.6
—
—
—
0
0
6
27
2.25
0.94
1.2
1.5
—
—
—
0
0
6
27
2.25
0.94
1.2
1.5
—
—
—
0
0
12
194
0.60
0.92
3.6
2.7
—
—
—
0
0
5
103
0.48
0.91
1.0
1.5
—
—
—
0
0
6
29
2.09
0.90
1.2
1.0
—
—
—
0
0
6
29
2.09
0.90
1.2
1.2
—
—
—
0
0
16
103
1.58
0.89
1.5
1.7
—
—
—
0
0
22
153
1.47
0.88
1.1
1.2
142.76
330.27
u/ml
0.58
22
138
6
30
2.02
0.87
2.2
3.0
56.83
57.90
%
—
6
30
42
330
1.32
0.85
2.2
1.9
1.46
1.36
%
0.37
34
296
12
73
1.67
0.83
1.2
1.6
—
—
—
0
0
18
122
1.51
0.82
1.6
2.9
2.42
1.36
mmol/l
1.15
12
95
6
33
1.83
0.79
1.2
1.3
—
—
—
0
0
5
97
0.51
0.79
1.2
1.4
417.80
332.38
mu/l
—
5
91
82
707
1.22
0.78
3.0
2.5
60.57
57.86
u/l
0.15
76
661
5
24
2.10
0.75
1.2
1.9
—
—
—
0
0
5
24
2.10
0.75
1.2
1.9
—
—
—
0
0
5
24
2.10
0.75
1.2
1.9
—
—
—
0
0
5
24
2.10
0.75
1.4
1.8
—
—
—
0
0
266
2565
1.28
0.74
4.8
4.4
2.94
2.87
mmol/l
0.51
254
2395
9
55
1.66
0.74
1.1
1.5
—
—
—
0
0
7
38
1.86
0.74
1.1
1.3
31.83
30.28
u/l
—
7
32
7
40
1.77
0.71
1.1
1.7
—
—
—
0
0
7
40
1.77
0.71
1.1
1.7
—
—
—
0
0
7
41
1.72
0.70
1.1
1.4
—
—
—
0
0
186
1738
1.18
0.70
3.6
3.0
57.96
45.22
u/l
0.85
171
1645
40
322
1.28
0.69
3.0
2.6
5.88
2.52
e6/l
0.72
21
158
252
2424
1.22
0.65
4.0
3.6
1.39
1.29
mmol/l
1.53
239
2258
251
2414
1.22
0.65
4.5
4.0
5.91
5.88
mmol/l
0.15
237
2234
5
29
1.74
0.64
1.4
1.6
—
—
—
0
0
32
254
1.29
0.63
1.9
3.1
3.62
8.82
umol/l
2.27
26
225
29
227
1.31
0.63
1.3
1.9
—
—
—
0
0
19
140
1.38
0.60
1.1
1.0
—
—
—
0
0
8
53
1.52
0.59
1.9
1.4
—
—
—
0
0
60
518
1.20
0.57
3.7
3.6
21.96
21.38
%
0.09
25
221
55
471
1.20
0.57
2.3
1.9
3.02
2.97
mg/l
0.05
48
407
32
258
1.27
0.56
8.8
6.4
—
—
—
0
0
8
55
1.47
0.56
1.1
1.3
—
—
—
0
0
13
90
1.46
0.56
1.2
1.4
—
—
—
0
0
40
333
1.23
0.54
2.6
1.7
916.31
1263.75
nmol/l
1.89
28
249
9
62
1.47
0.53
1.3
1.2
—
—
—
0
0
11
157
0.69
0.52
2.2
1.6
—
—
—
0
0
12
166
0.71
0.49
5.0
3.2
1.22
1.23
mmol/l
0.42
12
145
71
632
1.16
0.48
3.3
3.7
8.71
8.24
mg/mmol
0.04
45
405
5
33
1.52
0.41
1.4
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
187.26
—
0
15
0
18
0.00
0.40
0.0
1.6
—
7.78
—
0
18
16
124
1.31
0.39
6.7
11.6
23.92
24.59
mmol/l
0.20
16
118
0
19
0.00
0.39
0.0
2.3
—
17.59
—
0
19
8
115
0.69
0.37
6.4
9.0
24.04
25.09
mmol/l
—
8
115
53
592
0.87
0.36
5.2
3.2
0.00
0.01
estimate
0.50
11
189
24
201
1.21
0.33
4.9
2.4
0.24
0.22
g/l
0.81
24
193
43
381
1.15
0.32
2.6
2.5
0.54
0.74
ug/l
1.65
28
219
6
47
1.28
0.32
1.0
1.3
—
—
—
0
0
6
47
1.28
0.32
1.0
1.3
—
—
—
0
0
21
175
1.21
0.31
2.6
2.6
3.20
8.61
ug/l
2.27
21
155
7
55
1.28
0.30
1.3
1.4
58.86
263.31
pmol/l
—
7
55
7
57
1.23
0.29
2.1
2.5
25.76
24.89
mmol/l
—
7
57
41
457
0.88
0.28
1.9
1.7
474.78
28608034.55
pmol/l
0.76
36
395
11
87
1.27
0.24
1.4
1.4
—
—
—
0
0
10
125
0.79
0.23
1.7
2.0
—
—
—
0
0
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
56.86
—
0
12
0
14
0.00
0.20
0.0
4.5
—
811.93
—
0
14
0
14
0.00
0.20
0.0
2.3
—
—
—
0
0
25
222
1.14
0.20
5.4
11.5
13.01
12.67
kpa
0.09
25
214
25
222
1.14
0.20
5.5
11.5
5.02
5.10
kpa
0.19
25
212
6
52
1.16
0.19
1.2
1.3
—
22.04
—
0
9
25
224
1.13
0.17
5.5
11.5
1.22
1.45
mmol/l
0.07
17
179
7
61
1.15
0.17
1.7
4.4
25.39
34.58
mg/l
—
7
56
28
253
1.12
0.17
4.4
8.1
104.96
104.15
mmol/l
0.46
28
253
19
167
1.15
0.17
1.5
3.1
84.40
71.80
ml/min/173m2
—
5
75
86
821
1.07
0.17
3.0
3.2
19.90
85.96
ng/l
0.80
55
527
35
323
1.09
0.15
2.0
2.3
12.49
14.41
umol/l
0.83
35
300
29
315
0.91
0.14
1.6
1.7
—
—
—
0
0
21
190
1.11
0.13
6.2
12.4
122.81
120.95
g/l
0.16
21
185
92
891
1.05
0.11
4.2
3.2
—
—
—
0
0
25
232
1.08
0.10
4.8
4.5
2.68
8.23
ug/l
1.75
17
202
5
44
1.14
0.10
1.0
1.3
—
—
—
0
0
5
47
1.06
0.09
1.0
1.3
—
34.95
—
0
6
14
155
0.90
0.09
1.7
2.1
—
—
—
0
0
41
430
0.95
0.09
1.6
1.4
—
—
—
0
0
13
139
0.93
0.03
1.7
1.3
—
—
—
0
0
19
181
1.05
0.03
1.5
8.3
6.26
8.34
mmol/l
1.93
19
175
11
108
1.02
0.00
1.5
2.5
1.10
1.24
%
0.34
11
108
13
129
1.01
0.00
1.3
1.4
—
—
—
0
0
11
113
0.97
0.00
1.5
1.6
—
—
—
0
0
11
107
1.03
0.00
2.4
2.4
0.70
0.67
%
0.09
11
107
12
123
0.97
0.00
7.5
11.5
1.50
1.52
%
0.02
12
123
12
125
0.96
0.00
7.5
11.5
0.90
0.68
%
1.68
12
125
11
106
1.04
0.00
1.4
2.8
37.18
38.23
u/l
0.06
11
97
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
98.60
—
0
5
0
5
0.00
0.00
0.0
1.0
—
58.80
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
73
0.96
-0.00
1.1
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
89
1.01
-0.00
3.0
1.7
5.41
2.52
ug/l
—
9
81
5
54
0.92
-0.00
3.6
3.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
149.14
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
1.6
2.0
99.29
86.48
%
—
7
65
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
7
73
0.96
-0.00
1.1
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint M13_VILLONODULAR and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have M13_VILLONODULAR.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: M13_VILLONODULAR – Villonodular synovitis (pigmented)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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