No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
829 |
6. Filter based on genotype QC (FinnGen only) |
829 |
Control definitions (FinnGen only)
- Control exclude
- RHEUMA_ENDPOINTS
Extra metadata
- First used in FinnGen datafreeze
- DF12
Similar endpoints
↥List of similar endpoints to
Other specific arthropathies, wide
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5330 | 2986 | 2302 |
| Only index persons | 4747 | 2725 | 2022 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.06 |
| Only index persons | 0.09 | 0.10 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 47.23 | 48.64 | 45.31 |
| Only index persons | 45.54 | 47.24 | 43.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 829 | 516 | 313 |
| Unadjusted period prevalence (%) | 0.16 | 0.18 | 0.14 |
| Median age at first event (years) | 47.73 | 46.63 | 49.53 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 767
- Matched controls
- 7671
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
159.8
323.0
330
36
P01BA02
ATC
hydroxychloroquine; oral
153.5
323.0
347
41
M12.3
ICD-10 Finland
Palindromic rheumatism
+∞
323.0
322
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
969.5
227.5
212
*
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
62.5
224.0
259
62
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
68.2
193.1
220
45
A07EC01
ATC
sulfasalazine; oral, rectal
56.4
190.8
225
56
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
58.5
165.7
194
44
M12.2
ICD-10 Finland
Villonodular synovitis (pigmented)
+∞
156.8
145
*
M17.1
ICD-10 Finland
Other primary gonarthrosis
24.5
141.4
206
113
M13.9
ICD-10 Finland
Arthritis, unspecified
39.6
123.0
156
49
7192F
ICD-9 Finland
Other and unspecified disorder of joint, Villonodular synovitis[SYNOVITIS VILLONODULARIS, POLVI]
+∞
121.1
113
*
L88
ICPC
Rheumatoid/seropositive arthritis
182.7
120.2
123
8
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
117.8
104.2
111
11
NGB20
NOMESCO Finland
Primary total prosthetic replacement of knee joint without patellar part
+∞
103.5
97
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
106.9
102.1
110
12
H02AB06
ATC
prednisolone; systemic
4.7
88.8
493
2110
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
461.0
84.8
83
*
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
877.3
82.0
79
*
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
12.1
78.2
150
151
L04AA13
ATC
leflunomide; oral
288.9
78.0
78
*
M05.9
ICD-10 Finland
Seropositive rheumatoid arthritis, unspecified
791.3
74.5
72
*
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
+∞
68.8
65
*
M25.5
ICD-10 Finland
Pain in joint
4.1
61.9
314
1112
ND2DA
NOMESCO Finland
Bilateral hand X-ray examination
36.5
61.5
79
24
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
12.9
60.6
111
99
1220
FHL
Arthroscopy
16.4
59.5
98
68
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
7.9
58.6
143
215
M12.8
ICD-10 Finland
Other specific arthropathies, not elsewhere classified
+∞
55.9
53
*
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
30.7
52.4
70
25
NGF15
NOMESCO Finland
Total synovectomy of knee, arthroscopic
76.7
50.8
57
8
M01CB01
ATC
sodium aurothiomalate; parenteral
508.7
48.9
48
*
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
11.1
48.6
95
96
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
47.3
47.0
57
13
L04AB01
ATC
etanercept; parenteral
418.5
40.5
40
*
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
10.7
38.9
77
79
M12.0
ICD-10 Finland
Chronic postrheumatic arthropathy [Jaccoud]
+∞
38.9
37
*
NGR20
NOMESCO Finland
Intralesional or marginal excision of tumor of knee or lower leg
205.1
38.2
39
*
N02AX02
ATC
tramadol; systemic, rectal
2.7
35.6
356
1864
NG1CG
NOMESCO Finland
Knee and lower leg extensive MRI examination with high intensity magnet
20.3
35.3
53
28
WX320
NOMESCO Finland
Spinalanesthesy
3.4
34.2
193
688
M01AH05
ATC
etoricoxib; oral
2.6
34.2
487
3087
71220
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Palindromic rheumatism
+∞
33.6
32
*
1222
FHL
Arthroscopy and synovial surgery
66.5
33.3
38
6
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
5.9
33.0
97
183
NGB40
NOMESCO Finland
Primary total prosthetic replacement of knee joint with patellar part - sliding prosthesis
+∞
32.5
31
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.7
32.4
290
1402
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.3
32.2
104
220
M16.1
ICD-10 Finland
Other primary coxarthrosis
16.3
32.1
52
34
L15
ICPC
Knee symptom/complaint
3.4
30.7
171
599
NFB30
NOMESCO Finland
Primary total prosthetic replacement of hip joint not using cement
111.2
29.9
32
*
M01AH01
ATC
celecoxib; oral (coxibs)
3.3
29.8
173
624
TNG10
NOMESCO Finland
Puncture of knee
155.9
28.8
30
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
28.3
375
2197
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
15.7
28.1
46
31
M01AE02
ATC
naproxen; oral, rectal
2.3
27.8
463
3026
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
4.5
27.3
103
256
7140A
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SEROPOSITIVA]
+∞
27.2
26
*
M01CB03
ATC
auranofin; oral
+∞
27.2
26
*
ZX140
NOMESCO Finland
Intra articular
38.2
26.3
33
9
7151F
ICD-9 Finland
Osteo-arthrosis and allied disorders, Osteo-arthrosis, localised, primary[OSTEOARTHROSIS PRIMARIA, POLVI]
+∞
26.2
25
*
H02AB07
ATC
prednisone; oral
3.4
25.9
140
473
L04AB04
ATC
adalimumab; parenteral
31.3
25.2
33
11
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.3
25.2
337
1951
A02BC02
ATC
pantoprazole; systemic
2.2
24.3
504
3545
M13.0
ICD-10 Finland
Polyarthritis, unspecified
+∞
24.1
23
*
M05
ICD-10 Finland
Seropositive rheumatoid arthritis
+∞
24.1
23
*
NGF10
NOMESCO Finland
Total synovectomy of knee, open
+∞
24.1
23
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
89.7
23.8
26
*
N02AJ06
ATC
codeine and paracetamol; systemic
2.3
23.1
293
1634
Z96.6
ICD-10 Finland
Presence of orthopaedic joint implants
123.7
22.7
24
*
M09AX01
ATC
hyaluronic acid; parenteral
9.2
22.4
47
54
M79.6
ICD-10 Finland
Pain in limb
2.3
22.0
278
1538
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
+∞
22.0
21
*
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
39.9
21.8
27
7
M06.8
ICD-10 Finland
Other specified rheumatoid arthritis
226.2
21.7
22
*
M45
ICD-10 Finland
Ankylosing spondylitis
118.4
21.7
23
*
M01AC06
ATC
meloxicam; systemic, rectal
2.2
21.3
299
1731
M16.0
ICD-10 Finland
Primary coxarthrosis, bilateral
17.2
21.1
33
20
NF1AA
NOMESCO Finland
Hip X-ray examination
5.9
21.0
60
109
B01AB05
ATC
enoxaparin; parenteral
2.4
21.0
218
1093
M12.5
ICD-10 Finland
Traumatic arthropathy
+∞
20.9
20
*
D48.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bone and articular cartilage
13.4
20.8
36
28
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
79.0
20.8
23
*
M01AX05
ATC
glucosamine; oral
2.9
20.1
137
539
N03AX16
ATC
pregabalin; oral
2.4
19.8
190
911
M35.7
ICD-10 Finland
Hypermobility syndrome
205.0
19.6
20
*
M01AH02
ATC
rofecoxib; oral
3.0
19.4
120
443
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
12.6
19.2
34
28
H02AB04
ATC
methylprednisolone; systemic
2.8
18.2
130
524
M35.3
ICD-10 Finland
Polymyalgia rheumatica
12.8
18.2
32
26
NH3EA
NOMESCO Finland
Feet X-ray examination with load
11.8
18.1
33
29
NG1BG
NOMESCO Finland
Knee and lower leg MRI examination with high intensity magnet
6.5
18.0
47
76
9311
FHL
Knee cleansing surgery (synovectomy, debridement)
68.3
17.8
20
*
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
16.1
17.6
28
18
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
6.5
17.5
46
75
B01AF01
ATC
rivaroxaban; oral
3.7
17.4
80
236
L90
ICPC
Osteoarthrosis of knee
6.9
17.3
43
65
M79.0
ICD-10 Finland
Rheumatism, unspecified
6.8
17.1
43
66
N02BE01
ATC
paracetamol; systemic, rectal
2.3
17.1
644
5361
S18
ICPC
Laceration/cut
2.0
17.0
303
1894
L40.5
ICD-10 Finland
Arthropathic psoriasis
64.8
16.8
19
*
NG1AE
NOMESCO Finland
Knee joint ultrasound exmination
35.9
16.7
21
6
NG1DG
NOMESCO Finland
Knee and lower leg very extensive MRI examination with high intensity magnet
92.1
16.6
18
*
NG1DA
NOMESCO Finland
X-ray of knees
28.2
16.6
22
8
M01AB55
ATC
diclofenac, combinations; oral
3.9
16.3
68
185
SPAT1202
SPAT
Intra-articular injection
8.2
16.2
36
46
T84.0
ICD-10 Finland
Mechanical complication of internal joint prosthesis
25.1
16.1
22
9
M10.9
ICD-10 Finland
Gout, unspecified
6.9
16.0
40
61
M17.5
ICD-10 Finland
Other secondary gonarthrosis
61.3
15.8
18
*
WX111
NOMESCO Finland
Local infiltration anesthesia
61.3
15.8
18
*
L04AA17
ATC
[U] adalimumab; parenteral
+∞
15.7
15
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
15.7
15
*
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
4.7
15.6
53
118
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.1
15.3
91
324
M01AX17
ATC
nimesulide; oral
2.2
15.3
190
1016
M13.1
ICD-10 Finland
Monoarthritis, not elsewhere classified
29.3
15.2
20
7
ZXA05
NOMESCO Finland
Left side
2.2
15.0
186
991
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.8
14.9
64
179
L20
ICPC
Joint symptom/complaint NOS
6.3
14.7
39
65
L04AA11
ATC
[U] etanercept; parenteral
+∞
14.6
14
*
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
3.1
14.5
84
295
M07.3
ICD-10 Finland
Other psoriatic arthropathies
152.8
14.5
15
*
L04AX01
ATC
azathioprine; systemic
5.4
14.3
43
84
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
14.1
123
552
71239
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides NUD
54.4
13.9
16
*
1221
FHL
Arthroscopy and meniscus surgery
7.4
13.7
32
45
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
76.5
13.6
15
*
L04AB06
ATC
golimumab; parenteral
76.5
13.6
15
*
J01DB01
ATC
cefalexin; oral
2.0
13.6
607
5059
TNG11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in knee
+∞
13.6
13
*
7164A
ICD-9 Finland
Other and unspecified arthropathies, Transient arthropathy
+∞
13.6
13
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
34.7
13.5
17
5
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
21.6
13.4
19
9
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
8.8
13.3
28
33
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.1
13.3
75
258
1225
FHL
Arthroscopy and other therapeutic procedure
14.1
13.3
22
16
M23.8
ICD-10 Finland
Other internal derangements of knee
5.6
13.2
38
71
N02AA05
ATC
oxycodone; systemic
2.6
13.2
102
430
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.1
13.1
171
926
ZXA00
NOMESCO Finland
Right side
2.0
13.0
190
1074
M01AE03
ATC
ketoprofen; systemic, rectal
1.8
13.0
287
1890
M02AA07
ATC
piroxicam; topical
1.9
13.0
262
1672
M23.9
ICD-10 Finland
Internal derangement of knee, unspecified
3.1
13.0
74
257
L04AA01
ATC
[U] ciclosporin; systemic
11.8
12.9
23
20
71238
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Arthritis rheumatoides alia definita
71.1
12.6
14
*
NDG30
NOMESCO Finland
Fusion of wrist, total
+∞
12.5
12
*
71320
ICD-8 Finland
Osteo-arthritis and allied conditions, Traumatic spondylopathy
+∞
12.5
12
*
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
132.1
12.5
13
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
12.5
198
1158
M17
ICD-10 Finland
Gonarthrosis [arthrosis of knee]
3.4
12.3
61
192
M01AB05
ATC
diclofenac; systemic, rectal
1.7
12.2
491
3867
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.0
12.2
72
257
M16.9
ICD-10 Finland
Coxarthrosis, unspecified
5.9
12.1
33
58
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
3.6
12.0
54
158
M13.8
ICD-10 Finland
Other specified arthritis
16.7
11.7
18
11
XX9XE
NOMESCO Finland
Other ultrasound examination
30.5
11.7
15
5
M06
ICD-10 Finland
Other rheumatoid arthritis
66.0
11.6
13
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
11.6
274
1825
J01AA02
ATC
doxycycline; systemic
1.8
11.5
583
4883
7148X
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Other specified inflammatory polyarthropathies
121.8
11.5
12
*
N02AC04
ATC
dextropropoxyphene; oral
4.9
11.3
36
76
M00.9
ICD-10 Finland
Pyogenic arthritis, unspecified
17.4
11.2
17
10
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
11.4
11.1
20
18
T84.5
ICD-10 Finland
Infection and inflammatory reaction due to internal joint prosthesis
44.0
10.9
13
*
NG2AA
NOMESCO Finland
Patella X-ray examination
12.1
10.9
19
16
M02AA10
ATC
ketoprofen; topical
2.2
10.8
118
587
X59
ICD-10 Finland
Exposure to unspecified factor
2.1
10.7
130
680
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.0
10.6
42
110
A02BA02
ATC
ranitidine; systemic
2.0
10.6
143
779
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.3
10.4
53
171
TNX32
NOMESCO Finland
Custom moulded splint, unspecified region
3.6
10.4
46
133
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.3
10.4
102
483
SPAT1153
SPAT
Removal of sutures
1.8
10.4
218
1392
7177A
ICD-9 Finland
Internal derangement of knee, Chondromalacia of patella
9.0
10.3
21
24
A02BC03
ATC
lansoprazole; oral
1.8
10.3
207
1300
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.0
10.3
147
817
L03
ICPC
Low back symptom/complaint
1.9
10.2
169
991
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
10.1
128
680
NDL52
NOMESCO Finland
Tenosynovectomy of hand
40.6
10.0
12
*
M10.0
ICD-10 Finland
Idiopathic gout
7.8
9.9
22
29
M79.7
ICD-10 Finland
Fibromyalgia
6.1
9.9
26
44
A46
ICD-10 Finland
Erysipelas
2.2
9.8
99
477
NC1AA
NOMESCO Finland
Elbow X-ray examination without contrast
5.2
9.8
29
57
M25.4
ICD-10 Finland
Effusion of joint
13.6
9.7
16
12
M01AB01
ATC
indometacin; systemic, rectal
3.0
9.7
55
191
R06.0
ICD-10 Finland
Dyspnoea
1.9
9.6
171
1029
SPAT1263
SPAT
Sampling
1.7
9.5
289
2046
L28
ICPC
Limited function/disability (L)
2.2
9.5
99
484
L04AC07
ATC
tocilizumab; parenteral
+∞
9.4
9
*
J01FA10
ATC
azithromycin; systemic
1.6
9.3
413
3229
A02BC05
ATC
esomeprazole; systemic
1.6
9.3
287
2042
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
7.4
9.3
21
29
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.7
9.1
201
1294
NHM20
NOMESCO Finland
Excision of synovial ganglion of ankle or foot
9.2
9.1
18
20
WZA10
NOMESCO Finland
Long statement of health and health related matters
9.2
9.1
18
20
N03AX12
ATC
gabapentin; oral
2.1
9.0
104
532
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.9
8.9
55
201
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
8.9
128
712
J01FF01
ATC
clindamycin; systemic
1.8
8.9
189
1202
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.9
8.8
52
187
NHG77
NOMESCO Finland
Arthroplasty of interphalangeal tarsal joint(s)
7.3
8.8
20
28
M04AA01
ATC
allopurinol; systemic
2.4
8.8
74
324
M03BX02
ATC
tizanidine; oral
1.6
8.6
449
3622
M05BA04
ATC
alendronic acid; oral
2.6
8.6
61
243
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
20.3
8.5
12
6
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
8.5
121
669
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.7
8.4
35
97
H02AB08
ATC
triamcinolone; systemic
91.0
8.4
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
8.4
243
1688
WX204
NOMESCO Finland
Axillary plexus blockaced
4.4
8.4
29
68
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.2
8.4
89
438
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
6.3
8.4
21
34
L04AA24
ATC
abatacept; parenteral
+∞
8.3
8
*
NGC00
NOMESCO Finland
Exchange of a loose part of prosthesis in knee joint
+∞
8.3
8
*
212
Kela drug reimbursment
Gout
+∞
8.3
8
*
9522
FHL
Synovectomy
+∞
8.3
8
*
NGC20
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, normal prosthesis
+∞
8.3
8
*
M15.0
ICD-10 Finland
Primary generalized (osteo)arthrosis
5.9
8.3
22
38
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
4.9
8.3
26
55
L99
ICPC
Musculoskeletal disease other
7.2
8.3
19
27
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
8.3
147
880
SPAT1216
SPAT
Assessment of functional ability
2.1
8.2
99
515
L13
ICPC
Hip symptom/complaint
2.2
8.2
88
435
J01MA01
ATC
ofloxacin; systemic
2.4
8.1
70
310
R06AE07
ATC
cetirizine; oral
1.6
8.1
300
2216
NJ3NA
NOMESCO Finland
Measurement of difference in extremity lengty with X-ray
33.7
8.1
10
*
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
10.2
8.1
15
15
NFB40
NOMESCO Finland
Primary total prosthetic replacement of hip joint using hybrid technique
22.3
8.0
11
5
TQW40
NOMESCO Finland
Remowal of suture of skin
2.5
8.0
59
243
M15.8
ICD-10 Finland
Other polyarthrosis
7.3
8.0
18
25
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.6
7.9
226
1560
R52.9
ICD-10 Finland
Pain, unspecified
2.5
7.8
60
252
M01AH03
ATC
valdecoxib; oral
2.6
7.8
54
215
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.0
7.8
97
510
NHG24
NOMESCO Finland
Fusion of subtalar joint and between bones of ankle
45.4
7.7
9
*
B01AX06
ATC
[U] rivaroxaban; oral
45.4
7.7
9
*
NH3FA
NOMESCO Finland
Weight-bearing X-ray of foot
6.3
7.6
19
31
R01BA52
ATC
pseudoephedrine, combinations; oral
1.6
7.6
223
1545
NHG76
NOMESCO Finland
Arthroplasty of other tarsometatarsal joint
10.2
7.6
14
14
M01AE01
ATC
ibuprofen; systemic, rectal
1.8
7.5
656
5915
R03AK07
ATC
formoterol and budesonide; inhalant
1.8
7.5
142
865
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
7.5
353
2745
R51.80
ICD-10 Finland
Headache
2.0
7.4
97
520
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
7.4
151
940
N06AA09
ATC
amitriptyline; systemic
2.2
7.4
76
368
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
80.8
7.4
8
*
NF2AT
NOMESCO Finland
Injection to hip joint with ultrasound guidance
80.8
7.4
8
*
ZSN00
NOMESCO Finland
Procedure related to previous procedure classified in chapter N
13.5
7.4
12
9
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
7.4
57
239
J01FA06
ATC
roxithromycin; oral
1.6
7.4
283
2096
UJF32
NOMESCO Finland
Coloscopy
1.7
7.4
170
1103
9256
FHL
Synovectomy (knee 9311)
+∞
7.3
7
*
J01DA01
ATC
[U] cefalexin; systemic
1.5
7.3
437
3581
R03AC02
ATC
salbutamol; inhalant
1.5
7.2
364
2864
P01BA01
ATC
chloroquine; systemic
15.9
7.2
11
7
ZZH31
NOMESCO Finland
Bone allograft, small pieces
30.3
7.2
9
*
L12
ICPC
Hand/finger symptom/complaint
2.0
7.1
95
514
7170A
ICD-9 Finland
Internal derangement of knee, Old bucket handle tear of medial meniscus
6.7
7.1
17
26
Z50.1
ICD-10 Finland
Other physical therapy
2.9
7.1
41
145
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
5.7
7.1
19
34
M01AE11
ATC
tiaprofenic acid; oral, rectal
3.5
7.1
31
91
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
3.6
7.1
30
86
L17
ICPC
Foot/toe symptom/complaint
1.7
7.0
162
1050
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.6
6.9
183
1231
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.3
6.9
60
269
NGE10
NOMESCO Finland
Incision or suture of capsule of knee joint
13.9
6.9
11
8
C03CA01
ATC
furosemide; systemic
1.7
6.9
164
1070
NDU20
NOMESCO Finland
Removal of internal fixation device from wrist or hand
4.4
6.9
23
53
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
6.9
181
1214
M01AG01
ATC
mefenamic acid; oral
4.2
6.9
24
58
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
4.2
6.9
24
58
M01AC01
ATC
piroxicam; systemic, rectal
1.9
6.8
94
514
9243
FHL
Plastic of the patella and its tendons
11.1
6.8
12
11
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
6.2
6.8
17
28
M87.0
ICD-10 Finland
Idiopathic aseptic necrosis of bone
40.4
6.8
8
*
ND2BG
NOMESCO Finland
MRI of hand
40.4
6.8
8
*
M01AX01
ATC
nabumetone; oral
3.1
6.8
35
117
B01AX05
ATC
fondaparinux; parenteral
16.9
6.8
10
6
R52.2
ICD-10 Finland
Other chronic pain
3.7
6.6
27
75
D16.2
ICD-10 Finland
Benign neoplasm: Long bones of lower limb
12.4
6.6
11
9
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.6
6.6
192
1324
P01AB01
ATC
metronidazole; oral, rectal
1.5
6.6
273
2047
ZX120
NOMESCO Finland
Intravenous
2.2
6.6
66
319
G47.3
ICD-10 Finland
Sleep apnoea
1.7
6.5
137
860
E66.01
ICD-10 Finland
Obesity due to excess calories
2.4
6.5
53
231
M25.0
ICD-10 Finland
Haemarthrosis
10.1
6.5
12
12
M22.4
ICD-10 Finland
Chondromalacia patellae
3.9
6.5
25
66
L01
ICPC
Neck symptom/complaint
1.9
6.5
92
509
M54.5
ICD-10 Finland
Low back pain
1.6
6.5
211
1494
H02BX01
ATC
methylprednisolone, combinations; systemic
2.8
6.5
39
144
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
6.5
153
997
S83.6
ICD-10 Finland
Sprain and strain of other and unspecified parts of knee
2.9
6.5
37
131
NCF20
NOMESCO Finland
Operation for osteochondritis of elbow joint, open
70.4
6.4
7
*
NF1DA
NOMESCO Finland
X-ray of hips
14.4
6.4
10
7
M48.0
ICD-10 Finland
Spinal stenosis
2.1
6.4
69
344
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
6.6
6.4
15
23
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
3.7
6.3
26
73
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
2.3
6.3
56
254
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.9
6.3
90
500
9531
FHL
Arthrodesis of the hand joint
18.2
6.3
9
5
SPAT1229
SPAT
Assessment of need for aid
2.3
6.3
53
235
NGC60
NOMESCO Finland
Exchange or addition of patellar part
+∞
6.3
6
*
NGU00
NOMESCO Finland
Removal of partial prosthesis from knee joint, other or unspecified
+∞
6.3
6
*
293
Kela drug reimbursment
Baricitinib
+∞
6.3
6
*
NGC30
NOMESCO Finland
Secondary implantation of prosthesis in knee joint, special prosthesis
+∞
6.3
6
*
3006
Kela drug reimbursment
Baricitinib
+∞
6.3
6
*
L01CB
ATC
Podophyllotoxin derivatives
+∞
6.3
6
*
71250
ICD-8 Finland
Rheumatoid arthritis and allied conditions, Chronic rheumatoid nodular fibrositis
+∞
6.3
6
*
7140B
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Rheumatoid arthritis[ARTHRITIS RHEUMATOIDES SERONEGATIVA]
+∞
6.3
6
*
9503
FHL
Tendon or tendon sheath cleansing surgery (tenosynovectomy)
+∞
6.3
6
*
291
Kela drug reimbursment
Tofacitinib
+∞
6.3
6
*
7118F
ICD-9 Finland
Arthropathy associated with infections, Arthropathy associated with other infectious and parasitic diseases[ARTHRITIS POSTINFECTIOSA ALIA, POLVI]
+∞
6.3
6
*
L04AB05
ATC
certolizumab pegol; parenteral
+∞
6.3
6
*
TND10
NOMESCO Finland
Joint puncture, wrist or finger joint
+∞
6.3
6
*
NDG79
NOMESCO Finland
Other excision, reconstruction or fusion of joint of II-V finger
+∞
6.3
6
*
D48.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Connective and other soft tissue
4.5
6.2
20
45
WX002
NOMESCO Finland
Sedation and analgesia
1.8
6.2
115
699
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.1
251
1870
M67.4
ICD-10 Finland
Ganglion
2.4
6.1
47
200
M67.8
ICD-10 Finland
Other specified disorders of synovium and tendon
8.7
6.1
12
14
R05FB02
ATC
cough suppressants and expectorants
1.5
6.1
260
1954
1XC02
NOMESCO Finland
NA
10.1
6.0
11
11
J01MA12
ATC
levofloxacin; systemic
1.7
6.0
120
741
WX110
NOMESCO Finland
Local anesthesy
1.5
6.0
470
3988
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
101
41
27.91
145.72
1.8
1.2
15479.3
16171.1
e6/l
0.03
76
31
106
53
22.79
140.91
1.6
1.1
—
—
—
0
0
310
862
5.15
107.41
1.5
1.2
56.3
3.3
u/ml
11.31
147
345
59
13
48.79
100.72
1.4
1.0
51.4
83.8
%
—
36
6
299
916
4.54
89.63
1.5
1.2
71.2
18.3
iu/ml
5.19
158
252
84
115
8.02
59.06
1.7
1.5
0.4
0.1
iu/ml
0.83
17
20
507
2887
2.95
49.59
10.1
4.7
57.2
56.8
%
0.43
493
2696
508
2933
2.89
47.74
10.6
4.8
28.2
28.3
%
0.05
493
2726
582
3617
3.04
47.55
13.1
8.5
3.9
4.0
e9/l
0.77
538
3128
35
18
20.26
45.18
1.5
1.1
80491.2
40459.2
e6/l
0.22
26
11
662
4622
3.15
40.02
8.4
2.9
13.1
11.2
mm/h
2.99
641
4232
73
138
5.70
37.45
1.7
1.3
—
—
—
0
0
289
1456
2.51
32.58
3.0
2.3
338.4
8591.3
umol/l
7.35
262
1270
114
406
3.10
24.62
3.3
2.8
10.1
10.5
g/l
0.40
103
368
647
4966
2.38
23.71
10.3
6.9
74.3
78.3
u/l
2.35
627
4653
77
227
3.64
22.45
2.4
1.9
—
—
—
0
0
390
2512
2.04
22.07
2.6
2.2
77.8
76.5
nmol/l
0.37
361
2244
69
211
3.48
19.00
2.3
1.7
—
—
—
0
0
39
89
4.55
16.05
1.3
1.1
—
—
—
0
0
756
6568
2.72
15.68
20.6
11.9
17.0
24.8
mg/l
13.32
676
4990
420
3015
1.80
15.12
4.4
3.2
0.0
0.0
estimate
0.00
81
546
44
117
3.92
14.85
1.3
1.1
2.6
4.1
u/ml
—
5
16
43
117
3.82
14.06
1.3
1.1
4.6
2.4
u/ml
—
6
10
416
3041
1.74
13.53
6.5
6.8
1.2
1.2
mmol/l
1.08
362
2560
84
355
2.52
12.92
4.0
3.2
5.2
5.2
kpa
0.41
76
341
136
713
2.09
12.58
20.1
21.3
1.3
1.3
inr
0.06
43
83
80
337
2.52
12.39
3.6
3.2
3.0
1.9
mmol/l
2.01
54
260
28
61
4.72
12.19
1.5
1.2
—
—
—
0
0
408
3029
1.68
12.04
5.8
4.4
0.0
0.0
estimate
0.50
82
552
409
3048
1.67
11.82
4.5
3.2
0.0
0.0
estimate
0.80
83
529
35
97
3.72
11.17
3.1
3.3
57.7
55.6
%
0.35
35
97
263
1791
1.69
10.41
2.1
2.0
160.1
281.8
u/l
1.25
248
1696
33
93
3.65
10.29
3.2
2.9
4.0
4.1
e9/l
0.11
33
93
461
3628
1.61
10.10
4.4
4.8
6.6
6.7
mmol/l
0.72
439
3410
362
2740
1.57
9.01
4.3
3.8
—
—
—
0
0
60
258
2.43
8.90
1.7
2.3
35.5
40.2
u/l
0.95
55
237
715
6387
1.87
8.82
16.6
11.2
82.8
82.8
ml/min/173m2
0.01
642
5179
154
942
1.78
8.80
2.1
1.8
—
—
—
0
0
357
2746
1.53
7.97
5.5
6.0
1.2
1.2
mmol/l
0.87
329
2486
143
880
1.76
7.96
2.4
2.3
12.0
14.2
umol/l
3.05
135
816
205
1401
1.62
7.65
2.7
2.2
—
—
—
0
0
182
1225
1.62
7.19
3.0
2.3
4.1
6.4
e6/l
1.65
161
1069
129
795
1.74
7.11
4.1
4.1
31.6
32.1
%
0.25
112
528
227
1621
1.55
6.94
3.2
2.8
1084.7
1185.1
ng/l
0.21
195
1358
286
2149
1.51
6.89
2.7
3.5
2.3
2.4
mmol/l
0.78
253
1906
37
145
2.62
6.69
3.6
2.6
25.7
25.2
mmol/l
0.24
28
132
338
2643
1.47
6.62
4.7
4.6
35.4
35.9
g/l
0.74
318
2455
130
819
1.70
6.60
2.3
2.3
2.4
2.3
g/l
0.27
123
761
196
1383
1.55
6.25
1.7
1.6
1.1
1.1
mg/l
0.07
149
1043
120
755
1.69
6.11
2.4
2.3
20.6
24.3
%
2.44
107
642
36
147
2.51
6.02
1.3
1.3
—
—
—
0
0
92
551
1.75
5.59
1.9
2.1
321.8
389.9
nmol/l
2.83
85
513
5
0
+∞
5.21
1.4
0.0
1.6
—
mg/l
—
5
0
195
1423
1.48
5.21
2.5
1.9
3.2
3.0
mg/l
0.68
174
1184
492
4236
1.40
5.16
3.1
3.0
—
—
—
0
0
9
9
10.09
5.03
1.1
1.3
—
—
—
0
0
401
3350
1.38
4.97
6.3
6.5
9.7
11.4
umol/l
4.14
378
3193
740
6905
1.67
4.97
18.2
14.2
4.0
4.0
mmol/l
0.77
722
6679
738
6884
1.66
4.94
18.1
14.1
139.8
139.7
mmol/l
0.08
722
6669
672
6140
1.50
4.92
5.5
5.2
38.7
39.6
mmol/mol
1.95
639
5671
669
6110
1.49
4.88
5.2
4.6
1.8
2.1
mu/l
0.83
636
5596
300
2395
1.40
4.87
4.8
3.3
—
—
—
0
0
40
193
2.13
4.63
1.4
2.5
7.8
7.0
g/l
1.43
30
147
40
193
2.13
4.63
1.4
2.5
—
—
—
0
0
40
193
2.13
4.63
1.4
2.5
3.6
3.6
g/l
0.00
29
141
303
2445
1.38
4.54
2.0
1.9
94.4
95.7
pmol/l
0.17
182
1265
13
36
3.65
4.21
3.7
2.8
664.2
752.4
e6/l
—
5
16
146
1049
1.48
4.16
1.8
1.6
966.4
1197.6
nmol/l
2.89
116
792
38
190
2.05
4.04
1.4
1.7
—
—
—
0
0
288
2345
1.35
3.96
3.8
3.2
22.3
51.5
ng/l
1.13
204
1539
761
7220
1.66
3.93
17.4
8.9
25.3
26.4
u/l
1.32
749
6960
250
2014
1.35
3.64
2.8
2.4
57.0
55.8
u/l
0.17
240
1859
42
230
1.87
3.48
1.6
1.7
1.4
1.4
g/l
0.08
36
195
15
52
2.92
3.48
1.9
1.7
—
—
—
0
0
15
52
2.92
3.48
1.9
1.7
—
—
—
0
0
15
52
2.92
3.48
1.9
1.7
—
—
—
0
0
178
1369
1.38
3.46
1.6
1.5
19.0
20.5
nmol/l
0.78
157
1159
28
133
2.14
3.43
1.3
1.6
—
—
—
0
0
148
1110
1.41
3.33
1.6
1.5
—
—
—
0
0
264
2173
1.32
3.26
4.1
2.7
—
—
—
0
0
205
1629
1.34
3.22
5.6
3.3
0.0
0.0
estimate
0.80
81
540
10
28
3.60
3.20
3.5
3.4
—
—
—
0
0
464
4119
1.29
3.19
5.2
3.9
580.3
2943.0
e6/l
—
7
63
318
2698
1.29
3.10
3.0
2.6
101.0
129.5
ug/l
2.48
304
2502
57
355
1.65
3.08
1.8
1.6
—
—
—
0
0
205
1641
1.33
3.05
3.7
2.7
0.2
0.5
e6/l
4.58
158
1211
83
570
1.51
2.97
1.5
1.8
—
—
—
0
0
180
1429
1.33
2.82
1.3
1.2
0.6
1.7
u/ml
2.07
43
382
10
31
3.25
2.78
2.1
1.9
—
—
—
0
0
10
31
3.25
2.78
2.1
1.9
—
—
—
0
0
10
31
3.25
2.78
2.1
1.9
—
—
—
0
0
10
31
3.25
2.78
2.0
1.9
—
—
—
0
0
27
141
1.95
2.63
2.2
1.5
—
—
—
0
0
168
1334
1.33
2.63
4.9
3.3
1.0
1.0
kg/l
0.57
39
181
5
7
7.18
2.55
1.8
3.7
—
—
—
0
0
10
33
3.06
2.53
1.0
1.1
—
—
—
0
0
10
33
3.06
2.53
1.0
1.1
—
—
—
0
0
10
33
3.06
2.53
1.0
1.1
—
—
—
0
0
10
33
3.06
2.53
1.0
1.1
—
—
—
0
0
10
33
3.06
2.53
1.0
1.1
—
—
—
0
0
70
481
1.50
2.52
3.2
2.5
67.7
69.0
ml/min/173m2
0.09
29
201
559
5155
1.26
2.48
4.5
3.9
14.9
14.7
pmol/l
0.92
530
4698
9
26
3.49
2.48
2.0
2.2
—
—
—
0
0
14
57
2.48
2.46
2.4
1.9
—
—
—
0
0
17
78
2.20
2.32
2.2
1.5
—
—
—
0
0
17
79
2.18
2.26
2.2
1.5
—
—
—
0
0
17
79
2.18
2.26
2.2
1.5
—
—
—
0
0
17
80
2.15
2.20
2.2
1.5
—
—
—
0
0
30
173
1.76
2.19
1.5
1.5
302.4
292.2
ug/g
0.08
17
104
30
173
1.76
2.19
2.5
4.3
26.9
50.2
mg/l
0.78
25
147
30
173
1.76
2.19
2.5
4.3
30.1
50.7
mg/l
2.12
25
145
17
81
2.12
2.14
2.2
1.5
—
—
—
0
0
17
81
2.12
2.14
2.2
1.5
—
—
—
0
0
10
37
2.72
2.11
1.8
1.2
—
—
—
0
0
707
6755
1.32
2.10
4.5
4.2
4.7
4.8
mmol/l
0.46
673
6276
5
10
5.02
2.07
1.0
1.0
—
—
—
0
0
6
15
4.02
2.04
1.0
1.1
—
—
—
0
0
14
63
2.24
2.01
2.4
1.8
—
—
—
0
0
10
38
2.65
2.01
1.8
1.2
—
—
—
0
0
144
1162
1.29
2.00
3.2
3.5
62.8
355.8
ng/l
3.30
99
862
222
1888
1.24
1.98
3.7
3.8
17.9
8.3
mg/mmol
0.80
147
1163
8
27
2.98
1.94
1.0
2.7
—
—
—
0
0
20
106
1.91
1.92
3.3
2.1
127.5
130.1
g/l
0.21
14
81
27
158
1.73
1.91
1.2
1.3
—
—
—
0
0
56
392
1.46
1.89
3.2
3.3
4.2
4.5
pmol/l
1.77
50
348
24
136
1.79
1.89
1.6
1.8
—
—
—
0
0
7
22
3.20
1.88
1.9
2.5
—
—
—
0
0
11
46
2.41
1.85
1.2
1.0
—
—
—
0
0
678
6471
1.26
1.84
4.1
3.8
1.4
1.3
mmol/l
2.31
641
5955
715
6869
1.30
1.83
4.8
4.6
2.8
2.8
mmol/l
0.18
681
6345
5
12
4.19
1.82
1.0
1.7
—
—
—
0
0
85
648
1.35
1.78
1.6
1.9
—
—
—
0
0
700
6715
1.27
1.76
4.5
4.1
1.4
1.5
mmol/l
1.61
665
6198
18
97
1.87
1.67
1.8
2.0
—
—
—
0
0
29
181
1.62
1.65
3.2
2.8
—
—
—
0
0
140
1158
1.25
1.60
2.5
3.0
2.4
2.4
mmol/l
0.29
130
1029
61
450
1.38
1.58
2.6
2.8
177.4
188.3
ng/l
0.07
53
415
6
20
3.01
1.58
1.2
1.1
244.8
321.9
iu/ml
—
6
20
684
6564
1.24
1.58
4.6
4.2
5.9
5.9
mmol/l
0.00
643
6002
207
1792
1.21
1.54
4.3
4.5
2.1
2.5
ug/l
0.69
192
1605
487
4538
1.18
1.53
3.7
2.9
53.0
48.7
u/l
0.51
458
4255
5
15
3.35
1.52
1.0
1.1
—
—
—
0
0
5
126
0.39
1.51
1.2
1.4
—
—
—
0
0
5
126
0.39
1.51
1.2
1.4
—
—
—
0
0
5
126
0.39
1.51
1.2
1.4
—
—
—
0
0
5
126
0.39
1.51
1.2
1.4
—
—
—
0
0
120
983
1.26
1.50
3.3
2.4
0.8
1.2
e6/l
0.78
75
527
22
132
1.68
1.47
1.7
1.8
—
—
—
0
0
218
1904
1.20
1.47
3.2
3.0
7.3
7.6
mmol/l
0.31
199
1610
9
38
2.38
1.46
1.0
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
38
2.38
1.46
1.0
1.2
—
—
—
0
0
5
16
3.14
1.44
2.6
3.0
—
—
—
0
0
153
1296
1.22
1.41
1.6
1.6
449.9
47201924.4
pmol/l
1.95
128
1072
7
29
2.43
1.39
1.4
1.2
—
—
—
0
0
7
29
2.43
1.39
1.4
1.2
—
—
—
0
0
64
488
1.34
1.38
3.6
3.5
1.2
1.2
mmol/l
0.63
58
410
6
23
2.62
1.37
1.0
1.1
—
—
—
0
0
96
775
1.27
1.37
5.1
5.2
1.0
1.0
mmol/l
0.38
90
709
24
151
1.61
1.36
1.3
2.6
0.0
0.0
g/l
0.50
24
138
17
97
1.77
1.35
1.2
1.1
—
—
—
0
0
59
448
1.34
1.31
2.4
3.8
81.1
86.7
ng/l
0.23
51
393
596
6223
0.85
1.30
18.6
13.2
40.0
40.0
%
0.01
432
4600
6
24
2.51
1.30
2.7
2.1
—
—
—
0
0
6
24
2.51
1.30
2.7
2.1
—
—
—
0
0
6
24
2.51
1.30
2.5
2.1
—
—
—
0
0
25
161
1.57
1.30
1.1
1.1
—
—
—
0
0
21
130
1.63
1.27
2.0
1.4
—
—
—
0
0
56
426
1.34
1.24
1.9
1.6
—
—
—
0
0
8
37
2.17
1.21
1.3
1.3
—
60.0
—
0
6
8
37
2.17
1.21
1.4
1.3
—
—
—
0
0
8
37
2.17
1.21
1.4
1.3
—
—
—
0
0
238
2127
1.17
1.21
3.2
3.2
29.5
32.4
u/l
1.02
228
2027
53
687
0.76
1.18
1.5
1.8
—
—
—
0
0
25
166
1.52
1.16
1.3
1.4
7.9
11.2
u/l
0.49
14
135
5
20
2.51
1.15
1.0
1.8
—
—
—
0
0
532
5579
0.87
1.13
21.9
15.0
13.8
13.6
%
1.13
523
5434
22
143
1.55
1.12
1.3
2.6
0.0
0.0
g/l
0.00
22
131
25
168
1.50
1.11
1.5
2.6
0.6
1.7
g/l
1.01
25
151
120
1019
1.21
1.10
3.4
3.3
0.8
0.8
mmol/l
1.08
114
957
7
137
0.51
1.10
1.4
1.5
—
—
—
0
0
22
144
1.54
1.09
1.3
2.6
0.0
0.0
g/l
0.00
22
131
83
684
1.24
1.03
2.8
4.5
2.8
29.4
ug/l
1.50
60
565
10
53
1.90
1.01
1.5
1.2
—
—
—
0
0
25
173
1.46
0.98
1.4
1.2
—
—
—
0
0
12
69
1.75
0.97
1.3
1.2
—
—
—
0
0
14
222
0.62
0.96
1.3
1.5
—
—
—
0
0
24
167
1.45
0.93
1.6
1.3
—
—
—
0
0
8
42
1.91
0.88
1.0
1.1
199.1
228.0
mg/l
—
8
36
27
195
1.40
0.87
1.1
1.1
3.1
8.2
u/ml
—
5
25
85
719
1.20
0.85
2.4
2.7
8.5
9.1
umol/l
0.06
74
627
8
45
1.79
0.84
1.0
1.1
—
—
—
0
0
37
477
0.77
0.84
1.2
1.2
71.1
131.9
iu/ml
—
10
189
43
337
1.29
0.83
1.0
1.0
—
—
—
0
0
6
32
1.88
0.82
1.2
1.1
16.0
9.9
u/l
—
6
27
6
32
1.88
0.82
1.0
1.1
—
—
—
0
0
6
33
1.82
0.79
2.0
1.4
—
—
—
0
0
44
350
1.27
0.77
1.7
1.5
—
—
—
0
0
37
288
1.30
0.76
3.2
3.2
24.7
25.3
mmol/l
0.63
37
280
6
34
1.77
0.76
1.2
1.1
15.7
13.5
u/l
—
6
28
13
83
1.58
0.75
1.2
1.3
0.4
0.6
nmol/l
0.89
13
78
22
158
1.40
0.75
1.4
1.3
784.4
487.1
mg/l
0.54
22
151
5
24
2.09
0.74
2.6
4.5
—
—
—
0
0
6
108
0.55
0.72
1.5
1.6
—
—
—
0
0
78
667
1.19
0.71
1.7
1.8
—
—
—
0
0
9
58
1.56
0.70
1.8
1.4
—
—
—
0
0
9
58
1.56
0.70
6.8
2.2
—
—
—
0
0
5
91
0.55
0.67
1.0
1.1
—
—
—
0
0
5
28
1.79
0.66
1.0
1.3
5.5
6.6
mmol/l
—
5
28
14
95
1.48
0.64
1.3
1.7
—
—
—
0
0
5
29
1.73
0.64
1.0
1.4
—
—
—
0
0
5
29
1.73
0.64
1.2
1.0
—
—
—
0
0
68
583
1.18
0.62
2.1
2.3
41.5
35.9
u/l
0.22
59
492
18
130
1.39
0.61
1.6
1.5
—
—
—
0
0
17
122
1.40
0.60
1.4
1.3
—
—
—
0
0
17
122
1.40
0.60
1.4
1.3
—
—
—
0
0
8
53
1.51
0.58
1.0
1.0
331.5
294.0
mg/l
—
8
46
6
35
1.72
0.57
1.2
1.1
81.7
72.0
u/l
—
6
30
12
81
1.49
0.57
1.4
1.8
—
—
—
0
0
14
98
1.44
0.56
1.1
1.2
1.6
5.2
u/ml
—
5
26
11
73
1.51
0.56
1.4
1.8
—
—
—
0
0
165
1790
0.90
0.56
1.7
1.6
1.5
1.4
mmol/l
0.78
153
1501
10
65
1.55
0.55
1.2
1.3
—
12.4
—
0
20
10
148
0.67
0.55
1.1
1.5
—
—
—
0
0
12
82
1.47
0.54
1.3
1.3
—
0.7
nmol/l
—
0
7
15
108
1.40
0.53
4.6
2.3
15.7
16.3
%
—
10
51
76
668
1.15
0.53
1.8
1.8
—
—
—
0
0
6
39
1.54
0.53
1.3
1.9
—
—
—
0
0
39
324
1.21
0.52
1.5
1.3
22.4
33.8
iu/l
1.68
33
276
7
45
1.56
0.49
1.9
1.3
—
—
—
0
0
7
111
0.63
0.48
2.6
5.0
287.7
375.4
umol/l
—
7
99
12
85
1.42
0.47
1.2
1.5
—
—
—
0
0
158
1469
1.09
0.44
3.8
4.0
22.2
21.6
%
0.17
76
662
5
32
1.57
0.42
1.6
1.0
99.4
94.2
u/l
—
5
24
5
33
1.52
0.41
8.4
2.8
158.6
199.5
u/l
—
5
33
0
17
0.00
0.40
0.0
2.4
—
1.9
—
0
9
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
19
150
1.27
0.40
2.6
2.3
44.3
114.9
ug/min
1.09
12
93
8
60
1.34
0.40
3.9
4.0
—
—
—
0
0
66
589
1.13
0.40
2.9
3.1
—
—
—
0
0
84
761
1.12
0.40
7.9
6.2
—
—
—
0
0
8
61
1.31
0.39
1.1
2.0
—
—
—
0
0
28
233
1.21
0.39
1.5
1.5
—
—
—
0
0
16
124
1.30
0.39
1.2
1.5
—
—
—
0
0
72
648
1.12
0.38
6.8
9.6
0.4
1.2
mmol/l
0.77
56
507
11
80
1.38
0.38
1.5
1.6
—
—
—
0
0
9
67
1.35
0.38
1.0
1.1
—
—
—
0
0
9
68
1.33
0.37
1.0
1.1
—
—
—
0
0
9
69
1.31
0.37
1.4
1.6
—
—
—
0
0
6
47
1.28
0.32
1.3
3.0
—
—
—
0
0
13
102
1.28
0.30
1.5
1.6
—
—
—
0
0
12
93
1.29
0.30
1.2
1.1
—
—
—
0
0
7
57
1.23
0.29
1.9
1.3
—
—
—
0
0
5
73
0.68
0.26
1.2
1.5
—
—
—
0
0
9
73
1.24
0.25
1.1
1.1
—
—
—
0
0
24
207
1.16
0.25
1.3
1.3
195.1
247.2
miu/ml
0.37
13
102
37
333
1.12
0.22
1.7
1.9
—
—
—
0
0
7
93
0.75
0.22
1.4
1.1
—
—
—
0
0
7
94
0.74
0.22
1.7
1.7
—
—
—
0
0
27
305
0.88
0.22
2.1
1.7
4.9
5.2
mg/l
0.04
19
214
14
116
1.21
0.22
1.1
1.1
1.3
2.6
u/ml
—
6
41
29
325
0.89
0.21
5.1
9.3
25.7
25.0
mmol/l
0.45
29
320
0
11
0.00
0.21
0.0
3.8
—
0.6
—
0
11
12
98
1.23
0.21
4.2
2.8
7.4
6.1
u/ml
0.17
12
92
0
12
0.00
0.21
0.0
1.4
—
0.5
—
0
7
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
110
1157
0.94
0.21
1.5
1.4
—
—
—
0
0
11
89
1.24
0.21
1.0
1.0
1.6
1.5
g/l
0.56
11
83
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
7
59
1.19
0.18
1.1
1.2
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
19
167
1.14
0.17
2.6
3.0
0.3
0.4
u/ml
1.25
13
97
19
168
1.13
0.15
1.4
1.1
—
—
—
0
0
10
83
1.21
0.15
1.0
1.1
—
—
—
0
0
28
256
1.10
0.14
1.2
1.4
—
—
—
0
0
99
951
1.05
0.14
3.5
2.5
2.9
2.8
e6/l
0.03
54
493
12
103
1.17
0.13
1.1
1.0
1.1
2.3
u/ml
—
7
51
19
172
1.11
0.11
1.7
1.8
6.3
5.7
iu/l
—
5
64
104
1073
0.96
0.10
3.1
2.8
0.7
0.8
ug/l
0.42
77
669
56
535
1.05
0.10
3.0
3.4
2.2
2.0
mmol/l
0.17
42
429
14
125
1.12
0.10
1.1
1.1
1.2
77.1
iu/ml
—
5
23
5
46
1.09
0.09
1.0
1.0
255.8
327.6
ng/l
—
5
32
5
47
1.06
0.09
1.0
1.0
34.4
50.9
ng/l
—
5
32
6
58
1.03
0.08
1.0
1.0
—
—
—
0
0
30
318
0.94
0.08
1.9
1.3
—
—
—
0
0
81
830
0.97
0.06
2.0
1.8
1.5
1.4
%
0.41
69
738
18
168
1.07
0.06
1.4
1.1
—
—
—
0
0
23
240
0.96
0.03
1.8
1.8
—
—
—
0
0
14
133
1.05
0.01
4.1
3.5
23.4
24.0
mg/l
—
5
84
11
114
0.96
0.00
1.1
1.2
—
—
—
0
0
26
265
0.98
0.00
1.5
1.9
—
—
—
0
0
18
184
0.98
0.00
1.6
2.3
658.8
2767.1
u/l
—
9
72
10
102
0.98
0.00
1.0
1.1
—
—
—
0
0
27
269
1.00
0.00
3.9
3.2
48.4
50.1
%
0.14
27
264
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
6
66
0.91
0.00
1.8
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
10.8
—
0
9
0
6
0.00
0.00
0.0
11.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
54
0.93
0.00
1.0
1.4
0.9
1.0
g/l
—
5
54
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
7
69
1.01
0.00
1.4
1.9
72.3
21.0
ug/l
—
7
69
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint ARTHRO_SPEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ARTHRO_SPEC | 1.041 [0.88, 1.23] | 0.631 |
| Birth year | 0.997 [0.99, 1.01] | 0.483 |
During the follow-up period (1.1.1998 — 31.12.2019), 205 out of 1773 females with ARTHRO_SPEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ARTHRO_SPEC | 1.271 [1.08, 1.5] | 0.005 |
| Birth year | 0.989 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 220 out of 1252 males with ARTHRO_SPEC died.
Mortality risk
Mortality risk for people of age
years, who have ARTHRO_SPEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.28% |
| 5 | 0.608% | 1.685% |
| 10 | 1.514% | 4.008% |
| 15 | 3.05% | 7.209% |
| 20 | 5.688% | 12.403% |
Relationships between endpoints
↥Index endpoint: ARTHRO_SPEC – Other specific arthropathies, wide
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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