Risteys · M13_TRAUMARTHR

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M12.5 Hospital discharge: ICD-8 — 71320 Cause of death: ICD-10 — M12.5 Cause of death: ICD-8 — 71320 2 out of 7 registries used, show all original rules.	34
4. Check minimum number of events None	34
5. Include endpoints None	34
6. Filter based on genotype QC (FinnGen only)	34

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	405	180	219
Only index persons	286	141	145
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	48.26	50.92	45.93
Only index persons	43.66	48.12	39.34

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	34	21	13
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	44.60	44.86	44.19

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

unit

cases

controls

-log₁₀(p)

N cases

N controls

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

3.99

3.73

4.8

3.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

7.09

3.58

1.6

1.9

—

(3042936) Bacteria identified in Isolate by Culture

4.64

3.50

4.5

1.3

—

(3023368) Bacteria identified in Blood by Culture

3.71

3.19

9.9

3.7

—

(3026008) Bacteria identified in Urine by Culture

3.47

3.09

5.1

2.7

—

(3044640) Blood type and Crossmatch panel - Blood

3.37

2.91

1.9

2.2

—

(40768804) Tissue Pathology biopsy report

3.13

2.64

2.5

2.0

—

(3000494) Fungus identified in Specimen by Culture

4.42

2.55

1.0

1.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

3.32

2.52

2.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

4.61

2.40

2.4

1.8

—

(3022621) pH of Urine by Test strip

4.61

2.40

3.7

3.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

3.70

2.36

2.8

1.6

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.70

1.94

6.8

3.2

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

3.55

1.92

1.9

4.0

u/l

293.7

220.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

3.81

1.84

2.7

1.3

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

133

2.51

1.76

5.0

7.0

umol/l

8.5

10.0

0.74

127

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

3.60

1.75

2.7

1.3

—

(3016502) Oxygen saturation in Arterial blood

3.60

1.75

4.8

3.7

97.3

94.6

—

(36304419) Bacteria [Presence] in Urine

2.65

1.66

8.0

3.3

—

(3037467) Urinalysis macro (dipstick) panel - Urine

155

2.50

1.64

8.7

3.8

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

2.36

1.57

5.1

5.3

g/l

33.8

35.6

0.45

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

2.39

1.50

2.5

2.2

u/l

92.2

132.4

0.67

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.90

1.26

1.6

1.7

—

(3037522) Nuclear Ab [Titer] in Serum

2.90

1.26

1.2

—

371.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.75

1.19

1.8

1.5

—

(42870588) Differential panel, method unspecified - Blood

2.11

1.16

9.6

3.7

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

2.61

1.13

4.4

2.8

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

2.01

1.03

2.7

1.7

pmol/l

86.2

101.5

—

(3031040) Bacteria [#/volume] in Urine by Automated count

146

1.90

0.96

11.4

4.2

—

11496.8

—

(3044889) 12 lead EKG panel

167

1.90

0.92

4.8

3.8

—

(3009508) Creatinine [Moles/volume] in Urine

1.82

0.81

3.1

3.0

mmol/l

7.5

7.2

—

(3013512) EKG study

1.75

0.78

2.4

3.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

1.78

0.68

1.1

1.2

—

0.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.70

0.65

6.6

4.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.62

0.0

1.8

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.62

0.0

1.4

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

179

1.65

0.61

11.4

7.3

u/l

93.8

73.2

1.36

167

(40761511) CBC panel - Blood by Automated count

259

1.81

0.54

24.8

11.8

—

(40768797) Stomach Pathology biopsy report

1.72

0.45

1.0

1.2

—

(3033658) Prothrombin time (PT) actual/Normal

1.46

0.45

6.0

3.5

110.6

93.3

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.42

0.0

1.0

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

148

1.46

0.42

2.9

2.6

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

265

1.64

0.41

35.4

13.6

umol/l

79.3

78.0

0.07

265

(1761868) Lipid panel - Serum or Plasma

107

0.67

0.36

3.5

2.7

—

(3009542) Hematocrit [Volume Fraction] of Blood

229

1.35

0.25

35.2

12.0

39.9

41.0

0.36

173

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.22

0.22

1.2

1.3

—

(1002224) Polysomnography panel

0.00

0.22

0.0

1.4

—

(3037121) Protein [Mass/volume] in Urine

0.00

0.22

0.0

4.6

—

0.2

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.21

0.0

1.4

—

0.6

—

(4094501)

0.00

0.21

0.0

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.21

0.0

1.5

—

0.9

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(40758558) Short blood count panel - Blood

1.21

0.19

9.3

5.6

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.19

0.10

1.2

1.6

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

1.16

0.10

5.2

3.7

—

(3003694) ABO and Rh group [Type] in Blood

1.12

0.09

1.9

1.3

—

(3041096) Erythrocytes [Presence] in Urine by Automated

1.07

0.08

6.9

2.8

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

100

0.86

0.07

6.3

3.2

—

(3015736) pH of Urine

1.04

0.00

3.7

2.9

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.0

1.6

—

4.0

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

5.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.0

1.2

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

0.00

0.0

1.0

—

1.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

0.0

1.6

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.1

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.7

—

461.9

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.9

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

0.0

1.0

—

69.3

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.0

1.6

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.0

1.6

—

106.0

—

(3035933) Granulocytes/100 leukocytes in Blood

0.00

0.0

1.0

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.3

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.0

1.2

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

0.84

0.00

1.8

1.6

mmol/l

1.5

1.3

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.0

1.8

—

60.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_TRAUMARTHR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have M13_TRAUMARTHR.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

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Index endpoint: M13_TRAUMARTHR – Traumatic arthropathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	M13_TRAUMARTHR
CONTROL_EXCLUDE	M13_ARTHROPATHIES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M125
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	71320
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M125
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	71320
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Traumatic arthropathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints