Traumatic spondylopathy

M13_SPONDYLOTRAUM

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M48.3 Hospital discharge: ICD-8 — 7132 Cause of death: ICD-10 — M48.3 Cause of death: ICD-8 — 7132 2 out of 7 registries used, show all original rules.	90
4. Check minimum number of events None	90
5. Include endpoints None	90
6. Filter based on genotype QC (FinnGen only)	86

Control definitions (FinnGen only)

Control exclude: M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: M48
Name in latin: Spondylopathia traumatica

NAME	M13_SPONDYLOTRAUM
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M483
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	7132
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M483
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	7132
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Traumatic spondylopathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	861	449	403
Only index persons	672	376	296
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	59.90	63.11	56.48
Only index persons	59.56	62.52	55.79

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	86	52	34
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	56.39	58.52	53.13

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
90: Matched controls
900

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M48.3

ICD-10 Finland

Traumatic spondylopathy

+∞

92.2

M48.0

ICD-10 Finland

Spinal stenosis

121.9

31.2

N03AX16

ATC

[U] pregabalin

10.8

27.4

N03AX12

ATC

[U] gabapentin; oral

12.5

26.7

M54.5

ICD-10 Finland

Low back pain

8.4

23.3

108

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

9.6

22.2

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

28.3

20.7

N02AX02

ATC

tramadol; systemic, rectal

7.2

19.4

195

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

28.6

16.5

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

88.6

14.0

71320

ICD-8 Finland

Osteo-arthritis and allied conditions, Traumatic spondylopathy

+∞

12.8

M47.2

ICD-10 Finland

Other spondylosis with radiculopathy

+∞

12.8

ABC36

NOMESCO Finland

Decompression of lumbar nerve roots

+∞

11.7

L03

ICPC

Low back symptom/complaint

4.7

10.5

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

45.5

10.2

S22.0

ICD-10 Finland

Fracture of thoracic vertebra

24.9

9.7

M80.9

ICD-10 Finland

Unspecified osteoporosis with pathological fracture

111.2

9.6

N06AX21

ATC

duloxetine; oral

9.2

9.6

NA3AD

NOMESCO Finland

Lumbar spine and sacrum CT examination

41.2

9.2

NA2AA

NOMESCO Finland

Thoracal spine X-ray examination without contrast

21.4

9.2

S32.0

ICD-10 Finland

Fracture of lumbar vertebra

13.6

9.0

N02BF01

ATC

gabapentin; oral

11.0

8.2

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

3.5

8.0

229

M43.1

ICD-10 Finland

Spondylolisthesis

49.4

7.9

M03BX02

ATC

tizanidine; oral

3.5

7.6

325

NA3CG

NOMESCO Finland

Lumbar spine extensive MRI examination with high intensity magnet

87.0

7.5

H05BA01

ATC

calcitonin (salmon synthetic); nasal, parenteral

17.6

7.4

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

3.3

7.4

229

NAG62

NOMESCO Finland

Posterior fusion of lumbar spine with fixation, 2-3 vertebraea

+∞

7.4

NA2BG

NOMESCO Finland

Thoracal spine MRI examination with high intensity magnet

+∞

7.4

N05CD07

ATC

temazepam; oral

3.9

6.6

N05BA01

ATC

diazepam; systemic, rectal

4.3

6.4

ABC56

NOMESCO Finland

Decompression of lumbar spinal canal and nerve roots

+∞

6.3

M54.4

ICD-10 Finland

Lumbago with sciatica

4.6

6.2

SPAT1222

SPAT

Counselling/guidance promoting independent living

3.7

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

169

2.88

5.38

5.2

3.7

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

337

2.63

4.70

5.7

5.9

1.22

mmol/l

0.15

283

(3006315) Basophils [#/volume] in Blood

295

2.56

4.59

5.3

5.1

0.04

e9/l

0.02

253

(3001604) Monocytes [#/volume] in Blood

296

2.55

4.54

5.1

5.0

0.60

0.56

e9/l

0.46

254

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

3.76

4.24

1.9

1.4

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

277

2.46

4.23

2.3

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

122

2.73

4.21

3.7

3.5

1412.75

53.18

ng/l

0.47

101

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

269

2.35

3.82

2.1

73.28

77.30

nmol/l

0.45

238

(3045414) Leukocytes [Presence] in Urine

5.75

3.61

2.4

2.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

417

2.32

3.45

3.3

2.7

60.35

50.34

u/l

0.38

391

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

254

2.23

3.37

2.0

1.7

83.45

96.81

pmol/l

0.98

116

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

136

2.41

3.30

2.0

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

358

2.07

2.85

9.2

9.7

4.40

3.86

e9/l

0.80

312

(3044640) Blood type and Crossmatch panel - Blood

187

2.10

2.69

1.9

2.1

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

521

2.12

2.48

9.0

6.8

98.39

81.67

u/l

0.69

486

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

270

1.95

2.45

4.1

3.9

44.88

51.38

ng/l

0.08

206

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.07

2.44

4.4

6.0

0.74

0.65

0.37

(3031040) Bacteria [#/volume] in Urine by Automated count

421

1.97

2.41

6.8

4.1

—

4472.23

—

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

197

1.97

2.29

2.2

2.1

114.25

314.39

u/l

1.39

185

(3014007) Fractional oxyhemoglobin in Arterial blood

3.08

2.29

4.7

6.5

94.89

93.56

—

(40760892) CBC W Ordered Manual Differential panel - Blood

275

1.90

2.28

5.9

5.8

—

(3037467) Urinalysis macro (dipstick) panel - Urine

431

1.88

2.14

5.4

3.9

—

(3022217) INR in Platelet poor plasma by Coagulation assay

326

1.84

2.12

17.0

13.8

1.35

1.31

inr

0.09

109

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

5.22

2.10

1.0

1.2

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

2.76

2.01

4.6

6.0

1.39

1.30

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.91

1.99

1.4

1.8

—

(3042936) Bacteria identified in Isolate by Culture

2.18

1.96

2.1

1.9

—

(40758558) Short blood count panel - Blood

165

1.91

1.94

8.9

7.6

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

3.70

1.87

2.0

1.2

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

4.34

1.85

1.0

1.3

—

(3013707) Erythrocyte sedimentation rate by Westergren method

474

1.80

1.82

5.7

3.8

14.82

13.62

mm/h

0.22

425

(3019060) Gas panel - Arterial blood

2.47

1.78

2.0

2.9

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.02

1.73

2.7

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

2.14

1.71

1.2

1.3

—

(3019309) Folate [Moles/volume] in Red Blood Cells

131

1.90

1.69

1.6

1.5

1085.79

1153.99

nmol/l

0.10

(3026008) Bacteria identified in Urine by Culture

206

1.77

1.69

5.9

3.0

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

619

1.95

1.68

5.2

4.7

1.60

1.91

mu/l

1.95

546

(3043409) Potassium [Moles/volume] in Arterial blood

2.83

1.61

2.0

2.4

3.91

3.99

mmol/l

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

2.56

1.58

1.3

1.1

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

658

2.00

1.57

23.0

12.8

23.99

24.75

mg/l

0.06

513

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

103

1.93

1.55

3.7

2.5

4.06

3.19

e6/l

—

(3018405) Lactate [Moles/volume] in Arterial blood

2.72

1.55

2.0

2.3

1.06

1.45

mmol/l

—

(3020891) Body temperature

2.72

1.55

2.0

2.9

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

1.95

1.52

1.5

1.8

27.35

29.67

1.86

(3030467) Casts [#/volume] in Urine by Automated count

187

1.72

1.48

4.4

2.8

0.12

0.40

e6/l

1.61

142

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.85

1.46

1.7

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

3.24

1.46

1.0

1.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.72

1.39

2.0

1.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

494

1.64

1.38

4.4

4.1

15.11

15.12

pmol/l

0.01

433

(3016879) Cocaine [Presence] in Urine

3.05

1.37

1.0

1.4

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.14

1.34

1.5

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

2.60

1.32

2.3

1.3

—

(3028300) Cannabinoids [Presence] in Urine

2.88

1.30

1.0

1.3

—

(3027944) Amphetamines [Presence] in Urine

2.88

1.30

1.0

1.3

—

(3027008) Opiates [Presence] in Urine

2.88

1.30

1.0

1.3

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

247

1.61

1.29

5.3

2.8

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.01

1.25

1.4

1.5

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.87

1.24

3.3

4.7

104.87

104.49

mmol/l

0.10

(3035350) Ketones [Presence] in Urine by Test strip

315

1.55

1.22

6.8

3.8

0.00

estimate

—

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

2.40

1.20

3.5

1.6

—

(4094501) Cardiovascular stress test using bicycle ergometer

2.58

1.16

1.2

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.10

1.15

3.5

2.9

—

(40761511) CBC panel - Blood by Automated count

701

1.85

1.15

15.7

11.9

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

2.36

1.13

2.0

1.4

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

106

1.74

1.13

3.6

2.4

0.89

1.60

e6/l

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

209

1.57

1.12

3.4

1131.55

1747.46

ng/l

0.91

179

(3002582) Erythrocytes [#/volume] in Urine

218

1.56

1.12

4.4

2.9

35.62

366.40

e6/l

0.57

167

(3000330) Specific gravity of Urine by Test strip

2.04

1.12

9.4

4.2

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

2.46

1.10

1.2

1.3

47.80

42.05

nmol/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

321

1.51

1.09

8.5

5.3

0.00

estimate

—

(3009261) Glucose [Presence] in Urine by Test strip

321

1.51

1.09

6.9

3.8

0.00

estimate

—

(3000492) Spirometry study

2.01

1.06

2.0

1.7

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.92

1.03

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

249

1.51

1.03

6.2

4.1

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

143

1.61

1.02

6.3

3.4

—

(40761535) Cells panel - Urine sediment

1.89

1.00

6.3

3.2

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.82

0.98

3.1

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.82

0.98

2.5

1.7

—

(3018095) Leukocytes [#/volume] in Urine

252

1.49

0.97

4.8

3.2

65.05

70.82

e6/l

0.05

176

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.14

0.91

1.2

1.1

—

(36304419) Bacteria [Presence] in Urine

184

1.50

0.87

4.0

2.7

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.00

0.86

5.2

6.8

—

(3044889) 12 lead EKG panel

482

1.43

0.84

4.2

3.7

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.68

0.83

21.4

7.7

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.80

0.0

3.6

—

30.60

—

(40768443) Skin Pathology biopsy report

0.00

0.79

0.0

1.2

—

(3019225) pH of Specimen

1.74

0.77

6.0

5.0

—

(3022145) Colonoscopy Study observation

1.67

0.75

1.3

—

(3025941) Bacteria identified in Stool by Culture

1.86

0.74

2.3

1.3

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

128

1.51

0.73

1.2

1.3

5.72

0.74

u/ml

—

(3019550) Sodium [Moles/volume] in Serum or Plasma

701

1.54

0.72

24.8

14.7

139.07

139.89

mmol/l

2.08

679

(3004119) Hemoglobin [Mass/volume] in Venous blood

1.72

0.70

2.7

2.8

136.57

126.81

g/l

—

(1761482) Bacteria [#/volume] in Urine by Culture

1.90

0.69

8.8

5.2

—

(3022313) Gas panel - Capillary blood

1.90

0.69

2.0

4.5

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

648

1.45

0.69

4.5

4.6

6.05

5.93

mmol/l

0.32

579

(3009542) Hematocrit [Volume Fraction] of Blood

748

1.63

0.69

30.6

18.9

38.56

39.85

0.71

705

(3023103) Potassium [Moles/volume] in Serum or Plasma

705

1.50

0.65

24.4

14.8

4.07

3.99

mmol/l

1.41

683

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

1.52

0.59

1.3

1.2

1.07

6.66

u/ml

—

(3029937) Albumin [Presence] in Urine by Test strip

161

1.40

0.59

5.9

4.1

0.00

estimate

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.71

0.58

1.7

1.4

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.66

0.57

1.0

1.1

43.33

160.06

u/ml

—

(3012544) pH of Venous blood

1.48

0.54

2.6

3.0

—

(3000494) Fungus identified in Specimen by Culture

1.45

0.53

1.4

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

660

1.36

0.51

5.0

4.4

5.00

4.65

mmol/l

1.93

595

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

365

1.28

0.51

3.3

2.7

—

(1761868) Lipid panel - Serum or Plasma

250

0.74

0.50

3.1

3.0

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

653

1.32

0.46

4.9

4.4

1.53

1.51

mmol/l

0.12

582

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.40

0.0

2.5

—

(3037522) Nuclear Ab [Titer] in Serum

1.40

0.40

1.6

1.4

—

390.48

—

(3003694) ABO and Rh group [Type] in Blood

157

0.73

0.40

1.3

1.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.45

0.40

3.6

3.8

56.84

44.15

—

(3041096) Erythrocytes [Presence] in Urine by Automated

181

1.29

0.39

5.5

3.9

—

(40768793) Breast Pathology biopsy report

0.00

0.39

0.0

1.2

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.41

0.39

3.4

3.5

25.44

25.20

mmol/l

—

(3009343) pH of Capillary blood

1.50

0.37

1.8

4.1

—

7.40

—

(36660697) Celiac disease serology panel - Serum

1.50

0.37

1.2

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

243

1.22

0.32

2.2

3.3

2.35

2.36

mmol/l

0.04

217

(3013512) EKG study

198

1.22

0.28

5.0

3.9

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

630

1.18

0.23

5.2

5.6

39.19

40.08

mmol/mol

0.46

566

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

0.21

0.0

1.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

0.67

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.1

—

4.20

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.21

0.0

6.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.3

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

684

1.18

0.20

5.5

5.0

2.99

2.72

mmol/l

1.78

614

(3000991) Gas panel - Venous blood

1.19

0.20

6.5

5.6

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.14

0.16

2.6

3.1

—

(3002256) Pathology report gross observation

1.17

0.10

1.4

1.2

—

(3022621) pH of Urine by Test strip

1.07

0.09

2.2

3.2

—

(40761536) Microorganisms panel - Urine sediment

1.14

0.09

2.3

4.2

—

(3009508) Creatinine [Moles/volume] in Urine

195

0.90

0.09

2.4

2.9

7.14

7.34

mmol/l

0.06

157

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

634

1.09

0.09

4.3

3.9

1.43

1.26

mmol/l

0.79

558

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

1.08

0.09

1.2

1.8

—

(40768797) Stomach Pathology biopsy report

1.04

0.07

1.1

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

199

1.07

0.05

3.0

3.5

3.27

7.98

mg/mmol

—

122

(3007164) IgA [Mass/volume] in Serum or Plasma

113

1.07

0.02

1.4

1.72

2.53

g/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

634

1.03

0.00

19.3

12.6

79.64

77.12

ml/min/173m2

0.40

505

(40768804) Tissue Pathology biopsy report

267

1.02

0.00

1.4

2.2

—

(3012516) Albumin [Mass/volume] in Urine

184

0.97

0.00

2.6

3.0

5879.59

44.94

mg/l

—

114

(3020287) Protein C actual/normal in Platelet poor plasma by Coagulation assay

0.00

0.0

1.2

—

113.33

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

0.0

1.0

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.96

0.00

1.6

1.4

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

2.1

—

18.90

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.0

1.0

—

(46235689) Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex

0.00

-0.00

0.0

2.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.3

—

97.67

—

(3020629) Protein S Free Ag actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

1.1

—

102.63

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.5

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

10.14

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.2

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.3

—

(40762119) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.5

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.2

—

5.56

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

-0.00

0.0

2.3

—

44.13

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

6.5

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

-0.00

0.0

1.5

—

6.33

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(40768795) Lymph node Pathology biopsy report

0.00

-0.00

0.0

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.1

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.91

-0.00

1.4

—

(3011391) Calcitriol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.2

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

3.8

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

6.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3016038) Potassium [Moles/volume] in Urine

0.00

-0.00

0.0

1.2

—

22.40

—

(4200892) Spirometry reversibility

1.00

-0.00

1.4

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

3.8

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.92

-0.00

1.6

1.7

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.2

—

(40766048) U1 small nuclear ribonucleoprotein 70kD Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3022756) Ceruloplasmin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

285.60

—

(3023419) Bacteria identified in Sputum by Culture

0.00

-0.00

0.0

2.0

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.5

—

136.21

—

(3007798) IgG/Albumin [Mass Ratio] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3015183) Erythrocyte sedimentation rate

0.00

-0.00

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

-0.00

0.0

1.2

—

Mortality – FinRegistry

↥

Association

Association between endpoint M13_SPONDYLOTRAUM and mortality.

Females

Parameter	HR [95% CI]	p-value
M13_SPONDYLOTRAUM	1.502 [1.12, 2.01]	0.006
Birth year	0.994 [0.99, 1.0]	0.184

During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 278 females with M13_SPONDYLOTRAUM died.

Males

Parameter	HR [95% CI]	p-value
M13_SPONDYLOTRAUM	1.588 [1.09, 2.31]	0.015
Birth year	0.988 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 217 males with M13_SPONDYLOTRAUM died.

Mortality risk

Mortality risk for people of age

years, who have M13_SPONDYLOTRAUM.

N-year risk	Females	Males
1	0.098%	0.327%
5	0.726%	2.047%
10	2.085%	4.789%
15	4.192%	8.912%
20	7.266%	14.514%

Relationships between endpoints

↥

Index endpoint: M13_SPONDYLOTRAUM – Traumatic spondylopathy

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Traumatic spondylopathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints