Traumatic spondylopathy

M13_SPONDYLOTRAUM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M48.3
  • Hospital discharge: ICD-8 7132
  • Cause of death: ICD-10 M48.3
  • Cause of death: ICD-8 7132

2 out of 7 registries used, show all original rules.

88

4. Check minimum number of events

None

88

5. Include endpoints

None

88

6. Filter based on genotype QC (FinnGen only)

88

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M48
Name in latin
Spondylopathia traumatica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 861 449 403
Only index persons 672 376 296
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 59.90 63.11 56.48
Only index persons 59.56 62.52 55.79

-FinnGen-

Key figures

All Female Male
Number of individuals 88 53 35
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 55.91 57.95 52.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
81
Matched controls
809
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M48.3
ICD-10 Finland
Traumatic spondylopathy
+∞
79.9
63
*
M48.0
ICD-10 Finland
Spinal stenosis
132.3
26.5
27
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
44.1
20.8
25
8
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
37.8
14.6
18
6
M54.5
ICD-10 Finland
Low back pain
6.9
13.0
38
91
71320
ICD-8 Finland
Osteo-arthritis and allied conditions, Traumatic spondylopathy
+∞
12.8
12
*
N03AX12
ATC
gabapentin; oral
11.2
11.5
22
26
S22.0
ICD-10 Finland
Fracture of thoracic vertebra
69.4
10.9
12
*
N02AX02
ATC
tramadol; systemic, rectal
5.0
10.5
48
182
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
30.5
10.2
13
5
N03AX16
ATC
pregabalin; oral
6.0
9.6
29
69
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
+∞
9.6
9
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
56.2
8.9
10
*
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
23.1
8.8
12
6
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
99.9
8.6
9
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
6.0
8.3
24
53
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
28.1
7.8
10
*
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
87.7
7.5
8
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
+∞
7.4
7
*
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
7.4
7
*
N06AX21
ATC
duloxetine; oral
8.9
7.3
15
20
M03BX02
ATC
tizanidine; oral
3.6
7.0
52
271
M54.4
ICD-10 Finland
Lumbago with sciatica
9.4
6.6
13
16
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
29.2
6.4
8
*
N05CD07
ATC
temazepam; oral
4.6
6.1
22
61

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
165
2.86
5.18
5.3
3.6
—
—
—
0
0
48
290
2.44
4.08
5.5
5.0
0.0
0.0
e9/l
0.05
43
249
48
291
2.43
4.03
5.3
5.0
0.6
0.6
e9/l
0.51
43
249
9
17
5.76
3.61
2.4
2.1
—
—
—
0
0
25
119
2.54
3.47
3.7
3.3
1568.4
50.7
ng/l
0.47
18
99
41
248
2.22
3.29
2.0
1.7
81.8
96.8
pmol/l
1.14
25
114
11
34
3.55
3.18
4.4
6.0
0.7
0.7
%
0.28
11
34
10
31
3.51
2.87
4.7
6.5
94.9
93.3
%
—
10
31
41
264
2.04
2.68
4.1
3.9
44.9
52.1
ng/l
0.09
28
199
10
34
3.19
2.50
4.6
6.0
1.4
1.3
%
—
10
34
50
352
1.97
2.48
9.5
9.7
4.4
3.9
e9/l
0.77
45
307
31
188
2.00
2.33
2.0
2.0
—
—
—
0
0
55
416
1.86
2.05
6.9
4.1
—
4844.8
—
0
12
17
86
2.21
2.01
2.1
1.9
—
—
—
0
0
40
277
1.81
1.96
12.9
8.3
1.5
1.3
inr
0.30
12
92
55
423
1.80
1.87
5.4
4.0
—
—
—
0
0
5
12
4.35
1.85
1.0
1.3
—
—
—
0
0
30
195
1.82
1.78
2.3
2.1
119.8
319.4
u/l
1.36
30
183
7
24
3.08
1.76
2.0
1.8
1.1
1.5
mmol/l
—
7
24
7
25
2.95
1.69
2.0
2.9
—
—
—
0
0
71
600
1.95
1.67
5.3
4.7
1.6
1.9
mu/l
2.07
66
526
28
182
1.79
1.65
4.4
2.6
0.1
0.4
e6/l
1.70
20
138
8
32
2.65
1.64
1.3
1.2
—
—
—
0
0
30
200
1.76
1.62
5.7
2.9
—
—
—
0
0
26
166
1.80
1.62
9.1
7.4
—
—
—
0
0
58
464
1.73
1.62
5.7
3.8
14.9
13.1
mm/h
0.37
53
416
7
27
2.73
1.55
2.0
1.4
—
—
—
0
0
21
127
1.86
1.54
1.6
1.6
1085.8
1183.6
nmol/l
0.15
15
94
10
46
2.32
1.46
2.1
2.7
—
—
—
0
0
74
647
1.90
1.38
23.2
12.6
23.4
25.0
mg/l
0.14
63
505
5
17
3.05
1.38
1.0
1.4
—
—
—
0
0
16
92
1.90
1.36
1.5
1.8
27.3
29.7
s
1.77
16
87
5
18
2.88
1.30
1.0
1.3
—
—
—
0
0
12
63
2.05
1.30
1.4
1.5
—
—
—
0
0
28
195
1.64
1.26
4.3
4.6
—
—
—
0
0
5
19
2.73
1.23
1.0
1.3
—
—
—
0
0
5
19
2.73
1.23
1.0
1.3
—
—
—
0
0
5
19
2.73
1.23
1.0
1.3
—
—
—
0
0
30
214
1.61
1.23
4.4
2.7
35.6
370.9
e6/l
0.57
22
165
8
38
2.21
1.22
3.5
2.6
—
—
—
0
0
58
483
1.59
1.21
4.5
4.2
15.1
15.2
pmol/l
0.03
52
424
40
307
1.56
1.20
6.9
3.9
0.0
0.0
estimate
—
6
58
8
39
2.15
1.19
9.4
4.3
—
—
—
0
0
10
52
2.04
1.11
1.7
1.4
—
—
—
0
0
5
21
2.46
1.10
1.2
1.3
47.8
42.0
nmol/l
—
5
21
5
21
2.46
1.10
1.2
1.1
—
—
—
0
0
33
247
1.54
1.08
4.8
3.1
65.1
79.1
e6/l
0.13
24
173
76
685
1.80
1.07
15.6
11.9
—
—
—
0
0
11
61
1.92
1.04
1.5
1.5
—
—
—
0
0
40
315
1.49
1.03
8.5
5.4
0.0
0.0
estimate
—
8
57
40
315
1.49
1.03
7.0
3.9
0.0
0.0
estimate
—
7
57
21
143
1.62
1.02
6.3
3.4
—
—
—
0
0
9
50
1.89
1.00
6.3
3.2
—
—
—
0
0
25
180
1.54
0.96
4.0
2.5
—
—
—
0
0
0
27
0.00
0.79
0.0
1.2
—
—
—
0
0
9
53
1.78
0.78
6.0
5.0
—
—
—
0
0
9
53
1.78
0.78
1.3
1.3
—
—
—
0
0
7
39
1.86
0.74
2.3
1.3
—
—
—
0
0
21
156
1.45
0.69
5.9
4.1
0.0
0.0
estimate
—
8
57
5
27
1.90
0.69
8.8
5.2
—
—
—
0
0
7
43
1.68
0.68
1.7
1.7
—
—
—
0
0
69
629
1.45
0.68
4.4
4.7
6.1
5.9
mmol/l
0.31
59
562
5
28
1.83
0.67
2.0
4.4
—
—
—
0
0
54
474
1.36
0.66
4.2
3.7
—
—
—
0
0
17
122
1.49
0.66
6.9
5.3
—
—
—
0
0
74
685
1.50
0.65
24.8
14.5
139.1
139.9
mmol/l
2.10
69
665
17
124
1.46
0.61
1.2
1.3
5.7
0.7
u/ml
—
6
31
0
21
0.00
0.61
0.0
3.8
—
33.1
—
0
13
74
689
1.47
0.59
24.5
14.6
4.1
4.0
mmol/l
1.61
69
669
6
36
1.71
0.58
1.0
1.1
43.3
163.4
u/ml
—
6
31
13
92
1.48
0.54
1.3
1.3
1.1
7.0
u/ml
—
7
40
6
39
1.58
0.54
1.2
1.2
—
—
—
0
0
9
64
1.45
0.53
1.6
1.4
—
392.7
—
0
22
69
641
1.35
0.50
4.9
4.4
5.0
4.7
mmol/l
1.82
63
576
68
635
1.31
0.43
4.8
4.4
1.5
1.5
mmol/l
0.16
60
564
8
60
1.37
0.41
2.7
2.9
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
12
155
0.74
0.37
1.2
1.2
—
—
—
0
0
6
42
1.46
0.36
1.8
4.0
—
7.4
—
0
7
6
42
1.46
0.36
3.0
2.8
136.8
126.4
g/l
—
6
42
20
239
0.79
0.35
3.1
3.0
—
—
—
0
0
21
177
1.24
0.31
5.5
3.8
—
—
—
0
0
8
64
1.27
0.28
1.5
1.3
—
—
—
0
0
27
238
1.19
0.26
2.2
3.4
2.3
2.4
mmol/l
0.28
22
210
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
6
49
1.24
0.20
6.5
5.2
—
—
—
0
0
22
195
1.17
0.20
5.1
3.9
—
—
—
0
0
6
51
1.19
0.20
2.3
4.1
—
—
—
0
0
64
614
1.16
0.19
5.2
5.6
39.2
40.0
mmol/mol
0.37
56
552
62
594
1.15
0.18
22.2
13.1
39.3
39.5
%
0.06
38
427
69
666
1.17
0.18
5.4
5.0
3.0
2.7
mmol/l
1.76
63
597
17
192
0.86
0.17
2.2
2.9
7.1
7.5
mmol/l
0.10
12
154
5
43
1.17
0.10
2.2
3.1
—
—
—
0
0
9
87
1.04
0.07
1.4
1.2
—
—
—
0
0
63
618
1.07
0.05
4.3
3.9
1.4
1.3
mmol/l
0.78
55
543
17
181
0.92
0.05
2.4
3.0
5879.6
36.1
mg/l
—
8
111
26
270
0.95
0.04
1.4
2.2
—
—
—
0
0
20
195
1.03
0.00
2.8
3.7
3.3
4.9
mg/mmol
—
9
118
11
109
1.01
0.00
1.5
1.3
1.7
2.6
g/l
—
5
60
0
5
0.00
0.00
0.0
7.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.9
—
0.7
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
285.6
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
10.1
—
0
5
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
0.00
1.6
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
5.6
—
0
5
5
51
0.98
0.00
1.6
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
42.7
—
0
9
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
20.2
—
0
5
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
7
77
0.90
0.00
1.1
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
5.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_SPONDYLOTRAUM and mortality.

Females

Parameter HR [95% CI] p-value
M13_SPONDYLOTRAUM 1.502 [1.12, 2.01] 0.006
Birth year 0.994 [0.99, 1.0] 0.184

During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 278 females with M13_SPONDYLOTRAUM died.

Males

Parameter HR [95% CI] p-value
M13_SPONDYLOTRAUM 1.588 [1.09, 2.31] 0.015
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 73 out of 217 males with M13_SPONDYLOTRAUM died.

Mortality risk

Mortality risk for people of age

years, who have M13_SPONDYLOTRAUM.

N-year risk Females Males
1 0.098% 0.327%
5 0.726% 2.047%
10 2.085% 4.789%
15 4.192% 8.912%
20 7.266% 14.514%

Relationships between endpoints

Index endpoint: M13_SPONDYLOTRAUM – Traumatic spondylopathy

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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