No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
507 |
6. Filter based on genotype QC (FinnGen only) |
507 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other disorders of choroid
based on the number of shared cases.
Similar with more cases:
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4103 | 2132 | 1941 |
| Only index persons | 3629 | 1908 | 1721 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.05 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 63.92 | 67.31 | 60.08 |
| Only index persons | 62.24 | 65.65 | 58.46 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 507 | 257 | 250 |
| Unadjusted period prevalence (%) | 0.10 | 0.09 | 0.11 |
| Median age at first event (years) | 62.65 | 61.29 | 64.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 453
- Matched controls
- 4530
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H31.0
ICD-10 Finland
Chorioretinal scars
+∞
120.3
110
*
H31.3
ICD-10 Finland
Choroidal haemorrhage and rupture
+∞
102.0
94
*
H31.4
ICD-10 Finland
Choroidal detachment
+∞
81.8
76
*
H31.9
ICD-10 Finland
Disorder of choroid, unspecified
+∞
63.0
59
*
XCK10
NOMESCO Finland
Photography of fundus of eye
9.8
59.6
131
180
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
12.7
59.4
112
114
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
221.0
57.5
58
*
H31.8
ICD-10 Finland
Other specified disorders of choroid
+∞
51.0
48
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
9.2
50.3
113
157
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
507.4
47.2
46
*
WX140
NOMESCO Finland
Parabulbar anesthesy
21.2
44.3
66
36
H33.0
ICD-10 Finland
Retinal detachment with retinal break
+∞
43.4
41
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
5.8
41.9
135
308
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
410.2
38.6
38
*
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
130.0
34.2
36
*
S01EC01
ATC
acetazolamide; systemic
20.4
34.0
51
28
XCD10
NOMESCO Finland
Electrophysiological examination of eye
17.6
32.9
52
33
S01ED51
ATC
timolol, combinations; ophthalmic
6.5
32.8
92
171
H31.2
ICD-10 Finland
Hereditary choroidal dystrophy
+∞
32.7
31
*
XCD20
NOMESCO Finland
Photoangiography of eye
+∞
32.7
31
*
D31.3
ICD-10 Finland
Benign neoplasm: Choroid
37.4
32.4
41
12
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
32.3
131
372
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
13.2
30.3
54
46
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.2
28.5
211
969
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.3
28.4
65
89
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
35.4
28.2
36
11
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
+∞
27.4
26
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
3.0
26.4
217
1054
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
99.3
26.0
28
*
XCK00
NOMESCO Finland
Perimetry
6.2
25.7
73
136
H31.1
ICD-10 Finland
Choroidal degeneration
+∞
25.2
24
*
H33.3
ICD-10 Finland
Retinal breaks without detachment
+∞
24.2
23
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
35.5
23.6
30
9
114
Kela drug reimbursment
Glaucoma
4.4
23.2
91
243
S01ED01
ATC
timolol; ophthalmic
8.6
22.7
50
64
CKD40
NOMESCO Finland
Endophotocoagulation of retina
+∞
19.9
19
*
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
26.0
19.8
27
11
S01EX03
ATC
NA
10.5
19.5
38
39
S01EC03
ATC
dorzolamide; ophthalmic
14.9
19.4
32
23
CKC10
NOMESCO Finland
Local photocoagulation of retina
104.4
18.7
20
*
CKC12
NOMESCO Finland
Photocoagulation of retina
46.0
18.4
22
5
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
7.7
18.0
42
59
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
17.6
164
810
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.4
17.1
220
1282
S01EC04
ATC
brinzolamide; ophthalmic
6.9
16.7
42
66
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
41.7
16.5
20
5
H35.6
ICD-10 Finland
Retinal haemorrhage
+∞
15.7
15
*
S01EA03
ATC
apraclonidine; ophthalmic
24.4
15.2
21
9
S01EE01
ATC
latanoprost; ophthalmic
4.3
14.1
54
139
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.7
14.0
63
188
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
77.5
13.7
15
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.5
13.1
63
198
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
23.3
13.0
18
8
H26.4
ICD-10 Finland
After-cataract
3.3
12.6
67
227
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
+∞
12.6
12
*
H35.7
ICD-10 Finland
Separation of retinal layers
+∞
12.6
12
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
4.8
12.5
42
95
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.8
11.9
33
60
CKD15
NOMESCO Finland
Injection of vitreous substitute
+∞
11.5
11
*
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
16.0
10.9
17
11
ZXA10
NOMESCO Finland
Bilateral
2.4
10.8
100
476
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
61.5
10.7
12
*
S01BC03
ATC
diclofenac; ophthalmic
7.1
10.5
25
37
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
112.5
10.5
11
*
CKD20
NOMESCO Finland
Removal of vitreous body substitute
+∞
10.5
10
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
+∞
10.5
10
*
H35.4
ICD-10 Finland
Peripheral retinal degeneration
+∞
10.5
10
*
ZXA05
NOMESCO Finland
Left side
2.1
10.3
135
752
H26.2
ICD-10 Finland
Complicated cataract
19.3
10.3
15
8
XCH00
NOMESCO Finland
Eye pressure measurement
5.4
10.2
30
59
CHD00
NOMESCO Finland
Laser trabeculoplasty
11.7
10.1
18
16
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
41.0
10.0
12
*
CHD99
NOMESCO Finland
Other filtering operation
41.0
10.0
12
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
13.8
9.7
16
12
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
56.2
9.7
11
*
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
56.2
9.7
11
*
H34.8
ICD-10 Finland
Other retinal vascular occlusions
56.2
9.7
11
*
H27.0
ICD-10 Finland
Aphakia
30.7
9.4
12
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
30.7
9.4
12
*
H35.9
ICD-10 Finland
Retinal disorder, unspecified
+∞
9.4
9
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
9.4
9
*
WX002
NOMESCO Finland
Sedation and analgesia
2.2
8.9
102
533
S01EE05
ATC
tafluprost; ophthalmic
4.2
8.6
32
81
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
11.9
8.6
15
13
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
28.1
8.5
11
*
H35.37
ICD-10 Finland
Macular holes
+∞
8.4
8
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
+∞
8.4
8
*
H35.8
ICD-10 Finland
Other specified retinal disorders
+∞
8.4
8
*
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
8.4
8
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
7.4
8.0
18
25
S01EE04
ATC
travoprost; ophthalmic
5.6
7.9
22
41
ZXA00
NOMESCO Finland
Right side
1.9
7.9
137
840
CK9G4
NOMESCO Finland
Iridocyanine green angiography (ICGA) of choroid and retina
81.3
7.4
8
*
S01BC05
ATC
ketorolac; ophthalmic
3.6
7.4
32
94
S01EE03
ATC
bimatoprost; ophthalmic
5.1
7.4
22
45
CKD60
NOMESCO Finland
Anterior vitrectomy
9.6
7.3
14
15
H30.2
ICD-10 Finland
Posterior cyclitis
+∞
7.3
7
*
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
7.3
7
*
S01FA01
ATC
atropine; ophthalmic
30.5
7.2
9
*
H33.5
ICD-10 Finland
Other retinal detachments
30.5
7.2
9
*
C69.30
ICD-10 Finland
Malignant tumor of the chorioidea without histology
30.5
7.2
9
*
H40.9
ICD-10 Finland
Glaucoma, unspecified
6.5
7.0
17
27
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
14.0
6.9
11
8
S01EC54
ATC
brinzolamide, combinations; ophthalmic
9.5
6.8
13
14
H27.1
ICD-10 Finland
Dislocation of lens
17.0
6.8
10
6
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
17.0
6.8
10
6
H40.0
ICD-10 Finland
Glaucoma suspect
2.7
6.6
43
168
H53.1
ICD-10 Finland
Subjective visual disturbances
3.2
6.6
33
109
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.2
6.5
66
326
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
70.8
6.4
7
*
CHD10
NOMESCO Finland
Trabeculectomy
70.8
6.4
7
*
S01EA02
ATC
dipivefrine; ophthalmic
14.6
6.4
10
7
CHC05
NOMESCO Finland
Iridotomy
5.3
6.4
18
35
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
+∞
6.3
6
*
H3600, E113
ICD-10 Finland
NA
+∞
6.3
6
*
CM2X4
NOMESCO Finland
Follow-up OCT of age-related macular degeneration lesions
+∞
6.3
6
*
CKC15
NOMESCO Finland
Panretinal photocoagulation
+∞
6.3
6
*
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
6.3
6
*
CK2M4
NOMESCO Finland
Macular light layer imaging (OCT)
+∞
6.3
6
*
H3603, E103
ICD-10 Finland
NA
+∞
6.3
6
*
3636A
ICD-9 Finland
Chorioretinal inflammations and scars and other disorders of choroid, Choroidal haemorrhage and rupture
+∞
6.3
6
*
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
+∞
6.3
6
*
C69.32
ICD-10 Finland
Malignant tumor of the chorioidea melanoma
27.1
6.2
8
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.4
6.2
54
246
Z3231
NOMESCO Finland
Registered nurse
1.8
6.2
126
806
Mortality – FinRegistry
↥Association
Association between endpoint H7_CHOROIDOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDOTH | 1.061 [0.92, 1.22] | 0.4 |
| Birth year | 0.998 [0.99, 1.01] | 0.675 |
During the follow-up period (1.1.1998 — 31.12.2019), 525 out of 1781 females with H7_CHOROIDOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CHOROIDOTH | 1.09 [0.93, 1.27] | 0.272 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 417 out of 1549 males with H7_CHOROIDOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_CHOROIDOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.209% |
| 5 | 0.689% | 1.294% |
| 10 | 1.593% | 3.192% |
| 15 | 3.182% | 5.938% |
| 20 | 5.824% | 10.166% |
Relationships between endpoints
↥Index endpoint: H7_CHOROIDOTH – Other disorders of choroid
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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