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This is a non-core endpoint: only basic statistics are computed.

Brain medulloblastoma

DOID Endpoint Browser

C3_MEDULLOBLASTOMA

medulloblastoma: A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, large cell/anaplastic medulloblastoma, desmoplastic/nodular medulloblastoma, and medulloblastoma with extensive nodularity.

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Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

  • HLP_C3_MEDULLOBLASTOMA
13

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C71
  • Cause of death: ICD-9 — 191
  • Cause of death: ICD-8 — 191
  • Cancer registry: Topography ICD-O-3 — C71
  • Cancer registry: Morphology ICD-O-3 — 9470
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

13

4. Check minimum number of events

None

13

5. Include endpoints

13

6. Filter based on genotype QC (FinnGen only)

12

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE
Control conditions
not HLP_C3_MEDULLOBLASTOMA

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 12 11 -
Unadjusted period prevalence (%) 0.00 0.00 -
Median age at first event (years) 15.26 16.59 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

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OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
12
15.16
4.52
4.9
13.9
1.09
1.40
mmol/l
—
8
12
6
5
20.33
4.23
3.3
7.0
2.15
1.52
%
—
6
5
7
13
10.20
3.43
5.9
2.4
320.00
351.62
nmol/l
—
7
13
7
13
10.20
3.43
5.0
2.2
—
—
—
0
0
6
16
5.99
2.25
2.0
2.4
29.63
29.69
s
—
6
16
7
24
5.07
2.11
4.9
3.2
97.71
90.75
%
—
7
24
5
18
3.84
1.43
1.0
1.4
—
—
—
0
0
13
100
+∞
1.15
34.9
7.7
58.08
56.73
umol/l
0.08
13
100
6
31
2.71
1.00
46.0
5.2
—
—
—
0
0
0
27
0.00
0.89
0.0
1.8
—
44.38
—
0
22
0
21
0.00
0.67
0.0
1.3
—
—
—
0
0
13
109
+∞
0.67
20.8
6.5
—
—
—
0
0
0
16
0.00
0.44
0.0
1.3
—
—
—
0
0
0
14
0.00
0.44
0.0
5.2
—
308.29
—
0
14
0
17
0.00
0.44
0.0
1.6
—
—
—
0
0
0
17
0.00
0.44
0.0
1.6
—
—
—
0
0
0
17
0.00
0.44
0.0
1.6
—
—
—
0
0
6
78
0.57
0.42
4.7
5.0
—
—
—
0
0
5
35
1.69
0.29
1.4
1.9
—
—
—
0
0
5
37
1.57
0.28
2.2
1.9
—
—
—
0
0
8
64
1.64
0.25
3.6
3.0
294.75
44.91
ug/l
—
8
58
8
67
1.50
0.24
3.0
4.0
11.62
10.11
mm/h
—
8
61
0
12
0.00
0.22
0.0
1.2
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
5
44
1.22
0.12
1.0
1.9
—
—
—
0
0
13
122
+∞
0.00
50.5
12.9
5.45
6.99
e9/l
1.12
13
115
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
13
122
+∞
0.00
50.5
12.8
238.38
268.54
e9/l
0.79
13
116
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
13
122
+∞
0.00
50.5
12.8
4.00
4.51
e12/l
2.39
13
115
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: C3_MEDULLOBLASTOMA – Brain medulloblastoma

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).