Other hypersecretion of intestinal hormones

E4_HYPERSEC

endocrine system disease: A disease involving the endocrine system.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E34.1 Cause of death: ICD-10 — E34.1 2 out of 7 registries used, show all original rules.	19
4. Check minimum number of events None	19
5. Include endpoints None	19
6. Filter based on genotype QC (FinnGen only)	19

Control definitions (FinnGen only)

Control exclude: E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: E34
Name in latin: Alia hypersecretio hormonum intestinalium

NAME	E4_HYPERSEC
CONTROL_EXCLUDE	E4_ENDOGLAND
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E341
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E341
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other hypersecretion of intestinal hormones based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	109	44	64
Only index persons	92	39	53
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	57.81	54.87	59.82
Only index persons	55.57	50.03	59.65

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	19	6	13
Unadjusted period prevalence (%)	0.00	0.00	0.01
Median age at first event (years)	53.91	49.70	55.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3023368) Bacteria identified in Blood by Culture

4.09

2.26

5.0

6.5

—

(3032080) INR in Blood by Coagulation assay

3.03

1.64

28.3

10.5

1.6

1.2

inr

—

(36304419) Bacteria [Presence] in Urine

3.18

1.54

1.4

2.7

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

3.60

1.46

26.6

13.1

101.0

124.2

g/l

—

(3016502) Oxygen saturation in Arterial blood

3.19

1.30

26.8

12.1

96.9

94.8

—

(3044640) Blood type and Crossmatch panel - Blood

2.58

1.23

2.0

2.7

—

(3013512) EKG study

2.66

1.18

6.9

6.2

—

(3003396) Base excess in Arterial blood by calculation

2.85

1.17

26.6

11.6

0.6

3.0

mmol/l

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.34

1.09

1.7

2.8

—

(42870588) Differential panel, method unspecified - Blood

2.47

1.05

15.1

10.5

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

100

2.51

1.03

7.4

2.8

82.8

44.4

u/l

0.51

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

2.13

0.87

4.4

2.0

80.4

67.7

nmol/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.40

0.87

2.0

2.4

—

(40758558) Short blood count panel - Blood

2.32

0.86

13.4

8.5

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.86

0.0

1.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.85

0.68

3.4

4.2

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

1.67

0.54

3.1

2.8

59.6

56.8

u/l

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

1.69

0.52

6.0

3.6

49.3

28.9

u/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

1.78

0.47

5.1

4.2

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.43

0.0

1.3

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.42

0.0

1.5

—

(3000492) Spirometry study

0.00

0.42

0.0

1.6

—

(3009542) Hematocrit [Volume Fraction] of Blood

137

0.66

0.37

46.5

17.0

37.0

39.9

—

105

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.43

0.32

3.5

4.1

—

(3027008) Opiates [Presence] in Urine

0.00

0.22

0.0

1.2

—

(3000764) Benzodiazepines [Presence] in Urine

0.00

0.22

0.0

1.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.22

0.0

1.2

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.22

0.0

1.2

—

(3016879) Cocaine [Presence] in Urine

0.00

0.22

0.0

1.2

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

0.00

0.22

0.0

2.9

—

0.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.22

0.0

1.2

—

(3024354) Oxygen [Partial pressure] in Venous blood

0.00

0.22

0.0

12.5

—

4.7

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

44.3

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

0.00

0.21

0.0

13.5

—

5.7

—

(3013707) Erythrocyte sedimentation rate by Westergren method

104

1.42

0.20

9.9

3.9

10.1

10.8

mm/h

0.09

(3041096) Erythrocytes [Presence] in Urine by Automated

1.15

0.11

2.0

3.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.0

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.1

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.0

1.7

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

3.7

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.0

3.1

—

49.3

—

(40761535) Cells panel - Urine sediment

0.00

0.0

6.4

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.1

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

0.00

0.0

3.7

—

24.8

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.9

—

(3022621) pH of Urine by Test strip

0.00

0.0

1.9

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

141

0.97

0.00

5.4

4.5

2.3

2.8

mmol/l

1.68

130

(1761868) Lipid panel - Serum or Plasma

0.87

0.00

4.2

3.1

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.0

1.5

—

(3008898) HLA-B27 [Presence]

0.00

0.0

1.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

10.2

—

0.8

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3011288) Drugs identified in Urine by Screen method

0.00

0.0

1.2

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.2

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.0

5.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.00

0.0

1.4

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.4

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

0.92

0.00

2.0

4.6

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

0.0

1.8

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

8.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

2.6

—

(3044889) 12 lead EKG panel

101

0.98

0.00

7.4

3.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

135

1.14

0.00

5.1

4.0

5.8

6.0

mmol/l

0.33

126

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

139

1.03

0.00

4.9

4.2

4.6

mmol/l

1.39

129

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.3

—

(4094501)

0.00

0.0

1.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

0.00

0.0

10.2

—

0.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

139

1.03

0.00

5.0

4.2

1.5

1.4

mmol/l

0.32

128

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3045414) Leukocytes [Presence] in Urine

0.00

0.0

1.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.00

0.0

1.1

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.6

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYPERSEC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_HYPERSEC.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_HYPERSEC – Other hypersecretion of intestinal hormones

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other hypersecretion of intestinal hormones

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints