This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Other and unspecified acantholytic disorders

Endpoint Browser

L12_ACANTHNAS

No definition available.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L11.8, L11.9 Cause of death: ICD-10 — L11.8, L11.9 2 out of 7 registries used, show all original rules.	15
4. Check minimum number of events None	15
5. Include endpoints None	15
6. Filter based on genotype QC (FinnGen only)	15

Control definitions (FinnGen only)

Control exclude: L12_BULLOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	L12_ACANTHNAS
CONTROL_EXCLUDE	L12_BULLOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L11[8-9]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L11[8-9]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

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List of similar endpoints to Other and unspecified acantholytic disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	104	56	47
Only index persons	84	40	44
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	66.93	67.65	66.35
Only index persons	65.09	64.14	65.95

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	15	8	7
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	69.90	67.57	72.56

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

7.65

2.41

1.4

5.3

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

5.65

2.00

1.2

2.4

—

(3023368) Bacteria identified in Blood by Culture

4.37

1.90

4.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

4.78

1.77

1.2

2.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

4.05

1.71

2.0

2.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

3.96

1.68

12.0

3.7

—

(3042936) Bacteria identified in Isolate by Culture

4.13

1.58

2.8

3.1

—

(40768804) Tissue Pathology biopsy report

2.50

0.99

2.9

2.3

—

(36304419) Bacteria [Presence] in Urine

2.56

0.91

15.0

4.3

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.00

0.88

0.0

2.5

—

0.6

—

(40760892) CBC W Ordered Manual Differential panel - Blood

2.74

0.86

15.0

6.8

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

2.17

0.74

4.8

4.2

—

(3044640) Blood type and Crossmatch panel - Blood

1.96

0.64

1.5

1.8

—

(3026008) Bacteria identified in Urine by Culture

1.89

0.62

11.8

4.2

—

(3003694) ABO and Rh group [Type] in Blood

1.84

0.48

1.8

1.3

—

(3000850) Epithelial cells [#/volume] in Urine

1.64

0.44

20.6

3.5

5.1

5.8

e6/l

—

(4010399)

0.00

0.44

0.0

1.3

—

(3022145) Colonoscopy Study observation

0.00

0.44

0.0

1.3

—

(3022621) pH of Urine by Test strip

0.00

0.43

0.0

4.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

0.43

0.0

4.8

—

34.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.55

0.38

2.6

2.2

—

(3037467) Urinalysis macro (dipstick) panel - Urine

1.65

0.37

13.0

6.0

—

(42870588) Differential panel, method unspecified - Blood

1.42

0.26

12.6

4.3

—

(3000330) Specific gravity of Urine by Test strip

0.00

0.22

0.0

5.2

—

(4035726)

0.00

0.22

0.0

1.1

—

(3015736) pH of Urine

1.20

0.11

10.8

4.6

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

0.81

0.10

5.0

3.4

6.6

6.8

mmol/l

—

(3013707) Erythrocyte sedimentation rate by Westergren method

1.03

0.00

7.0

4.4

18.6

12.6

mm/h

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

1.06

0.00

17.2

4.6

1.2

mmol/l

—

(3044889) 12 lead EKG panel

1.00

0.00

4.6

4.2

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

0.00

0.0

4.3

—

40.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.0

1.0

—

(3049717) Cytology report of Urine Cyto stain

0.00

0.0

2.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.2

—

(3039000) Anion gap in Blood

0.00

0.0

6.8

—

10.4

—

(3017446) Testosterone [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

10.9

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

0.00

0.0

2.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

1.03

0.00

7.7

3.2

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.0

3.2

—

7.4

—

(36660697) Celiac disease serology panel - Serum

0.00

0.0

1.4

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

2.2

—

25.2

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

0.00

0.0

4.3

—

4.6

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.0

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.0

3.2

—

1.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.0

6.4

—

(3047181) Lactate [Moles/volume] in Blood

0.00

0.0

8.5

—

1.0

—

(4034850)

0.00

0.0

44.6

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.00

0.0

1.2

—

(3018572) Chloride [Moles/volume] in Blood

0.00

0.0

6.8

—

103.0

—

(3007930) Methemoglobin/Hemoglobin.total in Blood

0.00

0.0

5.3

—

1.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

0.00

0.0

5.3

—

1.7

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_ACANTHNAS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ACANTHNAS.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_ACANTHNAS – Other and unspecified acantholytic disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other and unspecified acantholytic disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints