vesiculobullous skin disease: Skin diseases characterized by local or general distributions of vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, distinguished by size (vesicles being less than 5–10 mm and bullae being larger than 5–10 mm). Vesiculobullous diseases are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. (From Scientific American Medicine, 1990, and Wikipedia)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2126 |
4. Check minimum number of eventsNone |
2126 |
5. Include endpoints |
2290 |
6. Filter based on genotype QC (FinnGen only) |
2240 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
Bullous disorders
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17606 | 9615 | 7867 |
| Only index persons | 14671 | 8199 | 6472 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.28 | 0.22 |
| Only index persons | 0.28 | 0.30 | 0.25 |
| Median age at first event (years) | |||
| Whole population | 66.48 | 67.70 | 64.95 |
| Only index persons | 64.83 | 65.56 | 63.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2240 | 1215 | 1025 |
| Unadjusted period prevalence (%) | 0.45 | 0.43 | 0.47 |
| Median age at first event (years) | 62.46 | 58.39 | 67.29 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 2290
- Matched controls
- 22900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D07AD01
ATC
clobetasol; topical
5.6
307.7
855
2198
K90.0
ICD-10 Finland
Coeliac disease
16.2
307.7
361
262
L13.9
ICD-10 Finland
Bullous disorder, unspecified
169.2
307.7
333
23
J04BA02
ATC
dapsone; oral
208.0
307.7
322
18
L12.0
ICD-10 Finland
Bullous pemphigoid
3245.9
307.7
793
*
L13.0
ICD-10 Finland
Dermatitis herpetiformis
7125.8
307.7
557
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
9.9
307.7
860
1312
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.6
255.2
877
2746
D07AC01
ATC
betamethasone; topical
4.0
236.1
1314
5732
L12.9
ICD-10 Finland
Pemphigoid, unspecified
503.0
232.5
228
5
TQW80
NOMESCO Finland
Local dermatologic skincare
9.0
163.6
210
253
E0000UV, ,
ATC
3.2
160.4
1304
6712
H02AB06
ATC
prednisolone; systemic
3.1
144.7
1451
8234
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.7
139.7
534
1720
L04AX01
ATC
azathioprine; systemic
6.7
136.3
230
377
69399
ICD-8 Finland
Dermatitis herpetiformis
+∞
134.7
128
*
L12
ICD-10 Finland
Pemphigoid
72.2
129.1
70
10
D07AC13
ATC
mometasone; topical
2.8
122.6
921
4375
L12.8
ICD-10 Finland
Other pemphigoid
+∞
116.7
111
*
D07AB08
ATC
desonide; topical
3.4
100.4
415
1385
L04AX03
ATC
methotrexate; systemic
3.6
95.5
360
1130
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
94.4
875
4492
E000001, ,
ATC
2.7
90.3
633
2828
XQ848
NOMESCO Finland
Dermatological photography
5.8
89.5
172
318
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
81.8
78
*
L10.0
ICD-10 Finland
Pemphigus vulgaris
795.0
78.8
77
*
135
Kela drug reimbursment
Pemphigus
+∞
76.5
73
*
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
75.4
72
*
L13.8
ICD-10 Finland
Other specified bullous disorders
106.3
75.4
82
8
ECA20
NOMESCO Finland
Biopsy of gingiva
10.2
73.1
83
84
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
72.8
995
5887
L11.1
ICD-10 Finland
Transient acantholytic dermatosis [Grover]
688.3
68.4
67
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.0
63.6
322
1193
D07BC01
ATC
betamethasone and antiseptics; topical
2.7
59.6
382
1601
L29.9
ICD-10 Finland
Pruritus, unspecified
5.1
59.5
130
269
L30.3
ICD-10 Finland
Infective dermatitis
4.4
54.1
141
337
R06AE07
ATC
cetirizine; oral
2.0
53.2
1044
6838
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
53.0
807
4835
D02AX
ATC
Other emollients and protectives
4.5
47.7
121
283
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.6
46.9
160
464
D09AB01
ATC
zinc bandage without supplements; topical
5.2
45.2
94
186
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
16.3
43.6
37
23
L29.8
ICD-10 Finland
Other pruritus
6.5
42.8
70
110
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
40.7
39
*
E000002, ,
ATC
2.4
39.0
296
1328
L10.2
ICD-10 Finland
Pemphigus foliaceus
+∞
38.6
37
*
A46
ICD-10 Finland
Erysipelas
2.1
38.3
417
2173
J01DB01
ATC
cefalexin; oral
2.0
37.3
1875
15783
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
36.7
399
2074
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.4
36.4
139
433
D02AE01
ATC
carbamide; topical
2.8
35.9
196
749
L10.8
ICD-10 Finland
Other pemphigus
+∞
35.5
34
*
L04AA06
ATC
mycophenolic acid; systemic
5.5
35.3
69
129
L20.0
ICD-10 Finland
Besnier prurigo
2.9
35.3
178
652
S97
ICPC
Chronic ulcer skin
2.7
34.9
204
807
R06AE09
ATC
levocetirizine; oral
2.2
34.6
345
1733
D07AA02
ATC
hydrocortisone; topical
2.1
34.2
350
1774
R06AX27
ATC
desloratadine; oral
1.9
34.0
604
3710
D05BB02
ATC
acitretin; oral
4.3
33.2
86
204
L30.0
ICD-10 Finland
Nummular dermatitis
3.3
33.2
131
416
L28.1
ICD-10 Finland
Prurigo nodularis
7.4
33.1
48
66
A02BC02
ATC
pantoprazole; systemic
1.8
33.0
1570
12681
EKA10
NOMESCO Finland
iopsy of buccal mucosa
4.4
32.9
84
197
S29
ICPC
Skin symptom/complaint other
1.9
32.9
484
2795
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
5.9
31.9
57
98
D07CC01
ATC
betamethasone and antibiotics; topical
2.1
31.5
330
1685
J01FF01
ATC
clindamycin; systemic
1.8
31.3
648
4151
6940A
ICD-9 Finland
Bullous dermatoses, Dermatitis herpetiformis
+∞
31.3
30
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
31.0
353
1859
S18
ICPC
Laceration/cut
1.7
31.0
1077
7946
S99
ICPC
Skin disease other
4.1
30.4
85
214
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
3.8
30.3
96
264
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.2
29.9
120
385
E000007, ,
ATC
2.8
29.5
153
568
A10AB05
ATC
insulin aspart; parenteral
2.4
29.0
220
983
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.7
28.5
162
631
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
27.9
550
3456
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
27.7
1109
8393
H02AB09
ATC
hydrocortisone; systemic
4.0
27.1
79
205
XQ802
NOMESCO Finland
Epicutan test
3.2
26.5
109
355
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
3.3
26.5
100
309
E000003, ,
ATC
2.9
26.5
125
441
S02
ICPC
Pruritus
3.1
26.4
111
366
L10.4
ICD-10 Finland
Pemphigus erythematosus
+∞
26.1
25
*
D07XC01
ATC
betamethasone; topical
2.0
26.0
301
1589
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
25.9
361
2032
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.3
25.8
216
1005
J01MA02
ATC
ciprofloxacin; systemic
1.6
25.4
911
6670
L30.8
ICD-10 Finland
Other specified dermatitis
3.6
25.2
83
235
C03CA01
ATC
furosemide; systemic
1.6
23.4
824
5979
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
23.3
451
2804
A10BH05
ATC
linagliptin; oral
2.4
22.5
157
675
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.8
22.2
115
427
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
3.5
22.0
77
227
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
22.0
609
4157
A10AE04
ATC
insulin glargine; parenteral
2.0
21.9
252
1325
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
21.6
285
1571
K12.10
ICD-10 Finland
Stomatitis NOS
8.3
21.4
28
34
K13.78
ICD-10 Finland
Other change in the oral mucosa
3.7
21.4
68
188
L04AD01
ATC
ciclosporin; systemic
4.3
20.9
54
128
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
3.8
20.7
63
169
SBA00
NOMESCO Finland
Microbiological examinations
3.4
20.6
75
227
XQ800
NOMESCO Finland
Prick test
2.3
20.6
160
721
ZY010
NOMESCO Finland
Hospital outpatient
2.6
19.8
117
465
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.6
19.7
120
484
A10AC01
ATC
insulin (human); parenteral
2.1
19.6
204
1032
E000006, ,
ATC
2.2
19.4
175
838
R60.0
ICD-10 Finland
Localized oedema
1.8
19.0
304
1777
H02AB07
ATC
prednisone; oral
1.8
19.0
332
1993
N02BE01
ATC
paracetamol; systemic, rectal
1.8
18.7
1976
17908
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
18.6
465
3078
J01AA07
ATC
tetracycline; systemic
1.8
18.5
299
1753
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
18.4
457
3018
L89
ICD-10 Finland
Decubitus ulcer and pressure area
3.3
18.0
67
206
SPAT1263
SPAT
Sampling
1.5
17.8
912
7064
L12.3
ICD-10 Finland
Acquired epidermolysis bullosa
+∞
17.7
17
*
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
2.8
17.6
87
315
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
17.4
783
5901
J01CF05
ATC
flucloxacillin; systemic
2.2
17.3
151
713
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.6
17.1
556
3907
L50.9
ICD-10 Finland
Urticaria, unspecified
2.8
16.9
87
322
S21
ICPC
Skin texture symptom/complaint
1.7
16.9
321
1971
RD210, ,
NOMESCO Finland
3.8
16.9
52
141
A28
ICPC
Limited function/disability NOS
1.6
16.8
453
3046
L11.0
ICD-10 Finland
Acquired keratosis follicularis
+∞
16.7
16
*
L10.1
ICD-10 Finland
Pemphigus vegetans
+∞
16.7
16
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.1
16.4
153
743
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
16.3
751
5670
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.5
16.2
719
5389
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.7
15.9
293
1783
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
7.3
15.7
23
32
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.0
15.7
172
887
D05AX52
ATC
calcipotriol, combinations; topical
2.3
15.6
118
525
SPAT1153
SPAT
Removal of sutures
1.5
15.3
704
5300
H02AB04
ATC
methylprednisolone; systemic
1.7
15.1
316
1988
R06AX13
ATC
loratadine; oral
1.7
15.1
286
1752
C07AB07
ATC
bisoprolol; oral
1.4
15.1
1136
9364
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
15.1
839
6547
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.6
14.9
389
2588
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
6.8
14.9
23
34
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
14.7
478
3343
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
14.7
663
4965
R06.0
ICD-10 Finland
Dyspnoea
1.5
14.7
613
4520
H13.3*L12.9
ICD-10 Finland
Ocular pemphigoid
+∞
14.6
14
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.2
14.6
58
186
S17
ICPC
Abrasion/scratch/blister
2.9
14.5
69
245
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
2.8
14.5
70
251
L01.1
ICD-10 Finland
Impetiginization of other dermatoses
6.6
14.5
23
35
R53
ICD-10 Finland
Malaise and fatigue
1.5
14.4
524
3752
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
3.8
14.4
43
114
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
14.3
239
1411
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.7
14.3
322
2063
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.7
14.2
279
1724
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
14.2
185
1011
N02AX02
ATC
tramadol; systemic, rectal
1.4
14.2
919
7345
K11.70
ICD-10 Finland
Hypoptyalism
6.2
14.2
24
39
J45
ICD-10 Finland
Asthma
1.8
14.1
217
1250
Z3231
NOMESCO Finland
Registered nurse
1.5
14.1
599
4427
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.0
14.1
147
745
SPAT1229
SPAT
Assessment of need for aid
1.8
13.9
199
1121
J01DA01
ATC
[U] cefalexin
1.4
13.9
1308
11138
J05AB11
ATC
valaciclovir; oral
1.7
13.9
303
1925
M79.6
ICD-10 Finland
Pain in limb
1.4
13.6
853
6765
69400
ICD-8 Finland
Pemphigus, Vulgaris, vegetans, foliaceus
+∞
13.6
13
*
L13.1
ICD-10 Finland
Subcorneal pustular dermatitis
+∞
13.6
13
*
R03AC02
ATC
salbutamol; inhalant
1.4
13.5
1123
9344
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.4
13.5
932
7516
J05AB01
ATC
aciclovir; systemic
1.5
13.5
454
3195
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.5
13.4
81
326
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.5
13.2
85
352
M05BA04
ATC
alendronic acid; oral
1.8
13.2
223
1320
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
13.2
606
4536
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.1
13.2
53
171
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.7
13.1
232
1392
L43.9
ICD-10 Finland
Lichen planus, unspecified
3.1
13.1
55
182
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
3.5
13.1
44
127
103
Kela drug reimbursment
Diabetes, insulin-treated
1.5
13.0
613
4610
R03BA01
ATC
beclometasone; inhalant
1.6
13.0
303
1958
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.7
12.9
269
1688
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.5
12.9
560
4146
TPH04
NOMESCO Finland
Cathetrisation of vein
1.5
12.8
475
3409
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
12.7
722
5614
SPAT1262
SPAT
Handing over of treatment supplies
1.5
12.6
391
2698
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
2.8
12.6
61
219
H04AA01
ATC
glucagon; nasal, parenteral
3.2
12.6
49
155
T90
ICPC
Diabetes non-insulin dependent
1.5
12.6
528
3879
SPAT1301
SPAT
No procedures
1.4
12.6
682
5258
L11.9
ICD-10 Finland
Acantholytic disorder, unspecified
+∞
12.5
12
*
D07XB05
ATC
dexamethasone; topical
2.6
12.5
69
266
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
3.8
12.5
37
98
L51.19
ICD-10 Finland
Other bullous erythema multiforme
130.7
12.4
13
*
R03BA02
ATC
budesonide; inhalant
1.6
12.4
366
2497
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
12.4
264
1667
L21.8
ICD-10 Finland
Other seborrhoeic dermatitis
3.9
12.4
36
94
J02AC01
ATC
fluconazole; systemic
1.4
12.3
732
5728
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.6
12.3
358
2435
SPAT1254
SPAT
Administration of medicine
1.6
12.3
351
2377
L43.8
ICD-10 Finland
Other lichen planus
3.1
12.3
51
168
L04AA01
ATC
[U] ciclosporin
3.8
12.2
36
95
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
12.2
902
7324
A10AA01, ,
ATC
2.8
12.2
60
218
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
12.5
12.1
21
17
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.7
12.0
254
1599
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.5
12.0
77
319
UJF32
NOMESCO Finland
Coloscopy
1.4
11.9
560
4199
L08.0
ICD-10 Finland
Pyoderma
4.6
11.9
28
62
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.4
11.9
589
4459
L73.8
ICD-10 Finland
Other specified follicular disorders
4.7
11.9
27
58
A10AB01
ATC
insulin (human); parenteral
2.4
11.8
77
322
WX110
NOMESCO Finland
Infiltration anesthesia
1.4
11.8
1423
12462
D11AH01
ATC
tacrolimus; topical
4.9
11.7
25
51
Z2221
NOMESCO Finland
Medical doctor
1.4
11.7
565
4258
Z43.5
ICD-10 Finland
Attention to cystostomy
4.8
11.7
26
55
P01BA02
ATC
hydroxychloroquine; oral
1.8
11.6
169
957
K12.18
ICD-10 Finland
Other forms of stomatitis
5.3
11.5
23
44
A02BC03
ATC
lansoprazole; oral
1.4
11.5
619
4753
A10AE05
ATC
insulin detemir; parenteral
2.0
11.5
124
637
B86
ICD-10 Finland
Scabies
3.0
11.4
49
165
AA1AD
NOMESCO Finland
CT of head and brain
1.4
11.1
615
4739
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
11.1
798
6423
B35.3
ICD-10 Finland
Tinea pedis
2.2
11.1
93
434
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
10.1
11.0
21
21
R03DC03
ATC
montelukast; oral
1.5
11.0
320
2175
S76
ICPC
Skin infection other
2.0
11.0
121
626
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.5
10.9
343
2372
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.2
10.8
89
412
D06AX01
ATC
fusidic acid; topical
1.7
10.7
197
1194
XQ845
NOMESCO Finland
Dermatoscopy
2.8
10.7
51
182
D07AC14
ATC
methylprednisolone aceponate; topical
2.1
10.6
104
516
J01AA04
ATC
lymecycline; systemic
1.6
10.6
238
1522
H3603, E103,
ICD-10 Finland
4.8
10.5
23
48
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
2.5
10.5
65
266
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
1.8
10.4
157
899
NHQ40
NOMESCO Finland
Amputation of toe
3.0
10.4
45
152
N03AX16
ATC
[U] pregabalin
1.4
10.4
478
3560
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
10.3
210
1311
A10AE06
ATC
insulin degludec; parenteral
2.3
10.2
74
325
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.0
10.2
112
579
A04
ICPC
Weakness/tiredness general
1.5
10.1
318
2195
L03.1
ICD-10 Finland
Cellulitis of other parts of limb
2.5
10.1
64
264
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
1.8
10.1
157
908
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
4.6
10.0
23
50
L13
ICD-10 Finland
Other bullous disorders
14.6
10.0
16
11
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
10.0
369
2635
I10
ICD-10 Finland
Essential (primary) hypertension
1.3
9.9
1348
11859
L43.1
ICD-10 Finland
Bullous lichen planus
16.8
9.9
15
9
B03BA03
ATC
hydroxocobalamin; parenteral
1.8
9.8
139
781
D01AE15
ATC
terbinafine; topical
1.8
9.8
151
872
N05BB01
ATC
hydroxyzine; systemic
1.9
9.6
130
720
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
1.8
9.6
138
779
T89
ICPC
Diabetes insulin dependent
2.2
9.6
80
373
L17
ICPC
Foot/toe symptom/complaint
1.4
9.5
576
4486
R06AX22
ATC
ebastine; oral
1.5
9.5
305
2113
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
15.1
9.5
15
10
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
2.9
9.4
42
145
69300, ,
ICD-8 Finland
+∞
9.4
9
*
WX002
NOMESCO Finland
Sedation and analgesia
1.4
9.3
410
3024
I50.9
ICD-10 Finland
Heart failure, unspecified
1.5
9.2
351
2517
RS222, ,
NOMESCO Finland
3.4
9.2
32
95
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.2
9.1
72
329
Z2446
NOMESCO Finland
Social worker
1.8
9.1
137
786
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
3.3
9.0
33
101
K12.00
ICD-10 Finland
Recurrent oral aphthae
3.3
9.0
33
101
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
2.9
9.0
40
138
SPAT1310
SPAT
Counselling related to known health issue
1.3
8.9
637
5086
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
2.7
8.9
46
172
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.5
8.9
346
2491
R01AD08
ATC
fluticasone; nasal
1.4
8.9
513
3960
B37.08
ICD-10 Finland
Other candidal stomatitis
3.9
8.9
25
64
D01AC02
ATC
miconazole; topical
1.7
8.8
167
1022
K59.09
ICD-10 Finland
Constipation, unspecified
1.7
8.8
151
899
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.0
8.8
91
461
D99
ICPC
Disease digestive system other
3.5
8.8
29
83
A07AA02
ATC
nystatin; oral
1.8
8.8
134
772
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.6
8.7
214
1396
R03AC12
ATC
salmeterol; inhalant
1.9
8.7
107
575
WX892
NOMESCO Finland
Monitored bed care
1.7
8.7
165
1011
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
2.1
8.6
81
396
SPAT1285
SPAT
Provision of consultation response
1.9
8.6
113
621
NH3BA
NOMESCO Finland
Foot and toes extensive X-ray examination
2.2
8.6
74
350
L30.4
ICD-10 Finland
Erythema intertrigo
3.1
8.6
35
115
J46
ICD-10 Finland
Status asthmaticus
2.3
8.5
62
273
L28.0
ICD-10 Finland
Lichen simplex chronicus
3.5
8.5
28
80
WW200
NOMESCO Finland
Immunization
2.4
8.5
56
236
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.5
8.5
281
1958
L29
ICD-10 Finland
Pruritus
3.2
8.5
33
105
A98
ICPC
Health maint/preventive medicine
1.5
8.5
2072
19696
K29.4
ICD-10 Finland
Chronic atrophic gastritis
2.4
8.5
54
224
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.5
8.5
321
2298
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
2.3
8.5
62
274
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.5
8.5
245
1660
N02AJ06
ATC
codeine and paracetamol; systemic
1.3
8.4
796
6606
L10
ICD-10 Finland
Pemphigus
90.4
8.4
9
*
SPAT1167
SPAT
Insertion of urinary catheter
2.1
8.4
81
400
XQ902
NOMESCO Finland
Other photography
4.3
8.4
21
49
E86
ICD-10 Finland
Volume depletion
2.3
8.4
64
288
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
1.7
8.3
137
806
A10BH02
ATC
vildagliptin; oral
2.5
8.3
51
208
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.1
8.3
75
362
R02
ICPC
Shortness of breath/dyspnoea
1.5
8.3
270
1877
SPAT1312
SPAT
General health counselling
1.3
8.3
615
4932
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.2
8.2
65
297
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
1.7
8.2
149
901
S01
ICPC
Pain/tenderness of skin
1.9
8.2
95
501
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
8.2
265
1838
J01FA01
ATC
erythromycin; systemic
1.5
8.2
234
1582
D11AX14
ATC
[U] tacrolimus
7.6
8.2
18
24
J01MA12
ATC
levofloxacin; systemic
1.4
8.1
390
2914
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.4
8.1
355
2609
Z71.8
ICD-10 Finland
Other specified counselling
1.3
8.1
568
4510
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
4.6
8.1
19
42
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
4.8
8.1
18
38
R50.9
ICD-10 Finland
Fever, unspecified
1.5
8.1
298
2121
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.6
8.1
168
1053
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
2.8
8.1
39
141
E000004, ,
ATC
2.7
8.1
42
158
A10AA02, ,
ATC
2.1
8.1
74
359
R11
ICD-10 Finland
Nausea and vomiting
1.6
8.1
176
1117
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
8.1
1368
12235
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
1.8
8.0
123
709
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
8.0
837
7029
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.6
8.0
170
1071
N18.8
ICD-10 Finland
Other chronic renal failure
2.3
8.0
60
268
J45.1
ICD-10 Finland
Nonallergic asthma
1.7
8.0
148
900
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
1.5
8.0
218
1458
J33.0
ICD-10 Finland
Polyp of nasal cavity
2.3
8.0
61
275
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.0
8.0
85
436
J01DA09
ATC
[U] cefadroxil
1.4
7.9
497
3880
107
Kela drug reimbursment
Pernicious anaemia
2.5
7.9
49
201
TDM10
NOMESCO Finland
Puncture of maxillary antrum
2.1
7.9
74
362
R03BA05
ATC
fluticasone; inhalant
1.4
7.9
347
2553
H3601, E103,
ICD-10 Finland
4.4
7.9
19
43
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
4.0
7.9
22
56
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
6.6
7.9
19
29
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
1.8
7.9
121
699
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.5
7.8
224
1514
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
7.8
335
2453
N02AA05
ATC
oxycodone; systemic
1.4
7.8
390
2933
A10AB04
ATC
insulin lispro; parenteral
2.2
7.8
60
271
N30.0
ICD-10 Finland
Acute cystitis
1.4
7.8
321
2333
SPAT1172
SPAT
Guidance concerning hydration
2.3
7.8
58
259
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
2.4
7.7
52
222
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
2.4
7.7
52
222
A10BA02
ATC
metformin; oral
1.3
7.7
607
4900
R01AD09
ATC
mometasone; nasal
1.3
7.7
816
6858
SPAT1298
SPAT
Other function in accordance with nutritional therapy nomenclature
3.9
7.7
22
57
XCW99
NOMESCO Finland
Other investigative procedure of eye
1.5
7.7
229
1561
N06AX11
ATC
mirtazapine; oral
1.3
7.7
660
5394
L04AA13
ATC
[U] leflunomide
2.4
7.6
50
211
Q82.80
ICD-10 Finland
Benign familial pemphigus [Hailey-Hailey]
25.1
7.6
10
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
2.4
7.6
52
224
ZXA05
NOMESCO Finland
Left side
1.3
7.6
515
4069
J01AA02
ATC
doxycycline; systemic
1.3
7.5
1606
14724
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
4.1
7.5
20
49
L23.9
ICD-10 Finland
Allergic contact dermatitis, unspecified cause
3.4
7.5
26
77
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.4
7.5
326
2392
E87.5
ICD-10 Finland
Hyperkalaemia
2.5
7.5
47
194
R4180
NOMESCO Finland
Podiatric therapy
3.0
7.5
32
108
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1.4
7.5
371
2785
A29
ICPC
General symptom/complaint other
1.5
7.5
262
1846
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
2.9
7.5
34
119
A02BC05
ATC
esomeprazole; systemic
1.3
7.5
794
6669
D20
ICPC
Mouth/tongue/lip symptom/complaint
1.9
7.5
91
489
Z3226
NOMESCO Finland
Physiotherapist
1.4
7.5
369
2770
H3600, E103,
ICD-10 Finland
3.7
7.5
23
63
N03AX12
ATC
[U] gabapentin; oral
1.4
7.4
321
2353
TQW99
NOMESCO Finland
Other minor procedure on skin
1.8
7.4
116
673
R01BA52
ATC
pseudoephedrine, combinations; oral
1.3
7.4
540
4306
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
1.7
7.4
143
880
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.6
7.4
180
1173
E11.4
ICD-10 Finland
Type 2 diabetes mellitus, with neurological complications
2.3
7.4
56
252
B00.19
ICD-10 Finland
Other vesicular dermatitis caused by the herper simplex virus
6.0
7.4
19
32
ZX120
NOMESCO Finland
Intravenous
1.6
7.4
186
1223
A02BC01
ATC
omeprazole; systemic
1.3
7.3
555
4452
L10.3
ICD-10 Finland
Brazilian pemphigus [fogo selvagem]
+∞
7.3
7
*
N17.9
ICD-10 Finland
Acute renal failure, unspecified
1.9
7.3
94
515
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
1.8
7.3
97
537
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
3.8
7.3
21
55
A41.9
ICD-10 Finland
Sepsis, unspecified
2.0
7.2
80
416
Z49.0
ICD-10 Finland
Preparatory care for dialysis
3.3
7.2
26
79
H36.01
ICD-10 Finland
Diabetic maculopathy
3.0
7.2
31
105
ZZA00
NOMESCO Finland
Split skin graft
2.1
7.2
67
327
ZXA00
NOMESCO Finland
Right side
1.3
7.2
552
4433
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.3
7.2
991
8588
N18.0
ICD-10 Finland
End-stage renal disease
3.1
7.2
29
95
SPAT1260
SPAT
Consultation of another employee
1.4
7.1
348
2605
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
3.4
7.1
25
75
L28.2
ICD-10 Finland
Other prurigo
6.0
7.1
18
30
L50.3
ICD-10 Finland
Dermatographic urticaria
2.7
7.1
37
140
SPAT1099
SPAT
Measurement of blood pressure with Doppler ultrasound device
2.0
7.0
73
372
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
2.3
7.0
48
207
A06AD11
ATC
lactulose; oral
1.4
7.0
337
2518
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
1.9
7.0
82
436
A12AA04
ATC
calcium carbonate; oral
2.6
7.0
38
147
SPAT1104
SPAT
Monitoring of emergency patient
1.7
6.9
135
834
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
6.9
393
3019
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
2.6
6.9
38
148
Z00.0
ICD-10 Finland
General medical examination
1.4
6.9
372
2833
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
2.4
6.9
43
178
B01AB05
ATC
enoxaparin; parenteral
1.3
6.8
633
5210
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.4
6.8
339
2544
B02.9
ICD-10 Finland
Zoster without complication
1.6
6.8
137
852
R49.08
ICD-10 Finland
Other specified dysphonia
2.4
6.8
45
191
XF600
NOMESCO Finland
Bloodpressure measurement
1.7
6.8
129
791
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.7
6.8
127
776
A08
ICPC
Swelling
1.7
6.8
113
669
SAA02
NOMESCO Finland
Basic examination of mouth
1.3
6.7
1228
10965
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
4.3
6.7
17
40
NHQ30
NOMESCO Finland
Amputation of foot, transmetatarsal
4.3
6.7
17
40
EBA00
NOMESCO Finland
Extraction of tooth
1.3
6.7
661
5480
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.7
569
4625
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.3
6.7
576
4691
Z02.7
ICD-10 Finland
Issue of medical certificate
1.6
6.7
136
848
177
Kela drug reimbursment
Insulin glargine 300 U / ml
2.4
6.7
44
186
QDA10
NOMESCO Finland
Incision of skin of lower limb
3.5
6.7
22
63
A01AC01
ATC
triamcinolone; local oral
2.6
6.7
37
144
SPAT1216
SPAT
Assessment of functional ability
1.4
6.7
343
2589
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.5
6.7
241
1709
C08CA01
ATC
amlodipine; oral
1.3
6.6
824
7031
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
1.5
6.6
208
1434
ZXA10
NOMESCO Finland
Bilateral
1.4
6.6
382
2937
S06
ICPC
Rash localized
1.7
6.6
113
674
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.1
6.6
57
271
L28
ICPC
Limited function/disability (L)
1.4
6.6
386
2975
B01AF02
ATC
apixaban; oral
1.4
6.6
275
2003
T36
ICD-10 Finland
Poisoning by systemic antibiotics
2.0
6.6
69
353
D05AX02
ATC
calcipotriol; topical
1.9
6.6
74
388
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.4
6.5
245
1749
L70.0
ICD-10 Finland
Acne vulgaris
2.8
6.5
32
117
NH3DA
NOMESCO Finland
Bilateral foot X-ray examination
2.4
6.5
42
176
K08.3
ICD-10 Finland
Retained dental root
1.6
6.5
148
950
S19
ICPC
Skin injury other
1.9
6.5
84
461
L53.9
ICD-10 Finland
Erythematous condition, unspecified
3.0
6.5
27
90
C03DA01
ATC
spironolactone; oral
1.4
6.5
256
1845
H57.1
ICD-10 Finland
Ocular pain
2.0
6.5
65
327
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.5
6.5
203
1399
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
3.7
6.5
20
55
J01CA08
ATC
pivmecillinam; oral
1.3
6.5
758
6420
A01AB09
ATC
miconazole; local oral
1.5
6.4
175
1170
A06AC01
ATC
ispaghula (psylla seeds); oral
1.3
6.4
526
4254
L01BA01
ATC
methotrexate; systemic
1.9
6.4
71
370
4047, ,
NOMESCO Finland
70.0
6.4
7
*
H36.00
ICD-10 Finland
Diabetic background retinopathy
2.8
6.4
30
107
N05BA04
ATC
oxazepam; oral
1.3
6.4
498
3999
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.8
6.4
97
559
J01EA01
ATC
trimethoprim; systemic
1.3
6.4
525
4248
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
1.5
6.4
177
1189
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
2.9
6.4
29
102
JN4AD
NOMESCO Finland
Body CT examination
1.5
6.4
195
1338
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
1.7
6.4
100
583
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
2.0
6.3
65
330
ZXE10
NOMESCO Finland
More than one and less than three hours
1.3
6.3
716
6035
L03.9
ICD-10 Finland
Cellulitis, unspecified
2.4
6.3
41
173
S87
ICPC
Dermatitis/atopic eczema
2.3
6.3
45
198
6BA02, ,
NOMESCO Finland
9.3
6.3
12
13
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
1.7
6.3
103
608
M13.9
ICD-10 Finland
Arthritis, unspecified
1.6
6.3
136
864
K02.1
ICD-10 Finland
Caries of dentine
1.2
6.2
1064
9397
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.0
6.2
64
325
L50.0
ICD-10 Finland
Allergic urticaria
2.2
6.2
48
218
L51.8
ICD-10 Finland
Other erythema multiforme
26.7
6.2
8
*
J01CA04
ATC
amoxicillin; systemic
1.3
6.2
1653
15352
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.3
6.2
507
4098
R01AD05
ATC
budesonide; nasal
1.6
6.2
140
898
C09BA02
ATC
enalapril and diuretics; systemic
1.5
6.2
176
1190
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.3
6.2
480
3854
A11CC03
ATC
alfacalcidol; systemic
2.2
6.1
51
239
M81.4
ICD-10 Finland
Drug-induced osteoporosis
5.3
6.1
17
32
Z94.0
ICD-10 Finland
Kidney transplant status
3.2
6.1
23
72
F03
ICD-10 Finland
Unspecified dementia
1.7
6.1
99
582
A01AB04
ATC
amphotericin B; local oral
1.7
6.1
100
590
WZC30
NOMESCO Finland
Teaching
1.4
6.1
292
2178
Z01.2
ICD-10 Finland
Dental examination
1.3
6.1
797
6827
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.4
6.1
327
2485
L03.0
ICD-10 Finland
Cellulitis of finger and toe
1.6
6.1
149
974
Q82.88
ICD-10 Finland
Other specified congenital malformations of skin
12.5
6.1
10
8
S81.9
ICD-10 Finland
Open wound of lower leg, part unspecified
3.0
6.1
25
83
SAA04
NOMESCO Finland
Special examination of mouth
1.7
6.1
102
606
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
2.1
6.1
52
247
K29.7
ICD-10 Finland
Gastritis, unspecified
1.9
6.1
71
378
R03AC03
ATC
terbutaline; inhalant
1.4
6.1
253
1843
5790A
ICD-9 Finland
Intestinal malabsorption, Coeliac disease
10.0
6.0
11
11
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.5
6.0
188
1296
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
636
113
77.54
307.65
2.6
1.1
31.00
14.38
u/ml
6.60
315
13
483
100
60.94
307.65
1.6
1.1
98.40
82.73
titre
0.18
50
11
80
22
37.64
129.04
1.1
1.0
—
—
—
0
0
1468
9495
2.52
95.50
9.7
5.8
0.22
0.19
e9/l
6.83
1338
8265
1458
9407
2.51
95.26
9.4
5.6
1.79
1.88
e9/l
1.57
1330
8253
1349
8667
2.35
84.92
10.0
6.1
8.90
8.74
%
1.02
1287
8078
1342
8630
2.34
83.90
9.6
5.8
3.15
2.82
%
5.17
1283
8028
1361
8865
2.32
81.68
9.8
5.9
26.07
27.02
%
2.45
1299
8282
1545
10727
2.35
78.16
11.7
8.7
4.30
4.20
e9/l
0.93
1400
9310
1334
8719
2.27
77.95
9.4
5.7
58.52
57.89
%
1.13
1278
8135
732
3731
2.41
77.30
1.6
1.2
4.67
1.63
u/ml
3.23
229
950
284
1015
3.05
59.66
1.4
1.2
596.26
217.26
u/ml
4.36
268
928
614
3281
2.19
54.99
1.7
1.5
2.58
2.52
g/l
0.29
378
1942
381
1671
2.54
53.73
2.6
2.1
348.62
373.83
nmol/l
1.70
352
1521
214
758
3.01
45.28
1.4
1.1
166.76
199.00
titre
0.12
17
14
816
5150
1.91
44.30
2.7
2.2
2.91
3.04
mg/l
0.72
706
4355
1182
8396
1.84
44.00
5.3
4.7
34.38
35.03
g/l
3.43
1086
7782
1321
9738
1.84
43.30
7.5
6.8
1.21
1.21
mmol/l
0.56
1126
8242
1689
13653
1.90
39.03
5.2
4.1
14.23
13.24
mm/h
1.82
1583
12558
78
151
5.31
38.42
1.2
1.2
—
—
—
0
0
443
2384
2.06
37.24
3.3
2.5
1.94
1.79
%
1.84
409
2099
1095
7870
1.75
36.75
3.5
2.8
144.03
133.28
ug/l
0.61
1013
7188
1749
14431
1.90
36.19
9.2
7.5
79.29
79.80
u/l
0.15
1660
13524
1192
8851
1.72
34.94
6.9
6.0
1.21
1.21
mmol/l
0.15
1087
8033
337
1700
2.15
33.32
2.2
2.6
66.40
66.14
g/l
0.26
313
1543
1111
8174
1.70
32.99
2.3
2.1
95.33
93.86
pmol/l
0.44
598
4213
525
3128
1.88
32.32
3.2
2.5
12.49
12.65
umol/l
0.18
493
2903
1056
7707
1.69
31.99
2.6
2.2
80.04
78.30
nmol/l
1.08
949
6794
166
620
2.81
31.69
1.2
1.2
2.25
0.74
u/ml
0.40
14
52
1281
9867
1.68
31.32
6.1
6.1
12.06
11.82
umol/l
0.22
1202
9343
619
3976
1.76
29.35
1.9
1.8
1214.54
1171.71
nmol/l
0.47
475
2983
1081
8094
1.64
28.50
14.1
9.7
0.00
0.00
e9/l
0.55
900
6583
334
1775
2.03
28.48
3.5
2.6
75.84
69.20
e9/l
2.40
259
1374
713
4797
1.71
28.48
1.8
1.6
19.36
20.38
nmol/l
1.04
619
4066
47
78
6.13
27.22
1.0
1.2
—
—
—
0
0
38
50
7.71
27.22
1.8
1.3
8.63
8.93
ug/l
0.16
38
50
2036
18166
2.09
27.14
22.7
15.6
23.68
25.27
mg/l
1.48
1720
14640
1394
11237
1.61
26.22
5.6
4.8
7.12
6.80
mmol/l
4.69
1316
10548
133
488
2.83
26.22
1.8
1.5
0.22
0.23
g/l
0.87
126
462
136
507
2.79
26.02
1.7
1.5
1.18
1.17
g/l
0.07
131
479
1195
9298
1.60
25.97
17.1
17.5
1.31
1.33
inr
0.28
336
2651
445
2706
1.80
24.93
3.3
2.6
21.95
22.52
%
0.37
374
2305
81
228
3.65
24.77
1.7
1.4
—
—
—
0
0
1514
12573
1.60
24.06
5.9
4.8
4314.76
1539.43
e6/l
0.87
25
196
462
2874
1.76
23.84
3.2
2.5
2.26
2.29
g/l
0.53
436
2646
252
1332
2.00
21.54
3.0
2.7
10.63
10.64
g/l
0.01
233
1206
214
1066
2.11
21.49
1.8
1.8
1.26
1.43
g/l
0.60
201
967
382
2314
1.78
21.40
3.7
4.0
240.58
246.16
u/l
0.34
362
2176
120
472
2.63
20.69
1.3
1.2
62.79
37.69
u/ml
0.32
11
23
115
449
2.64
20.12
1.3
1.2
7.17
9.17
u/ml
0.18
25
78
316
1841
1.83
20.07
2.4
2.2
0.21
0.21
g/l
0.28
294
1723
112
442
2.61
19.19
1.3
1.2
9.73
3.32
u/ml
0.92
18
41
773
5732
1.53
18.93
3.5
3.3
771.64
304.29
mg/l
1.21
518
3653
801
6002
1.51
18.59
3.7
3.2
6.86
7.26
mmol/l
1.92
676
4989
2057
18877
1.88
18.54
25.4
18.3
139.19
139.62
mmol/l
9.59
2011
18370
251
1393
1.90
18.51
4.8
3.8
0.48
0.71
%
1.40
89
471
96
357
2.76
18.48
1.3
1.2
1.43
5.62
u/ml
0.78
11
26
161
761
2.20
18.45
2.0
2.5
9.93
10.40
g/l
0.82
150
679
113
457
2.55
18.42
1.2
1.1
38.09
6.02
u/ml
0.90
15
47
191
966
2.07
18.38
1.8
1.8
1.47
1.51
g/l
0.21
163
831
607
4303
1.56
18.10
1.9
1.7
14458266.37
22087186.00
pmol/l
0.20
498
3527
344
2115
1.74
18.09
2.4
2.7
10.04
8.85
umol/l
0.34
294
1846
167
808
2.15
18.05
2.0
2.4
3.64
3.68
g/l
0.15
156
730
905
6987
1.49
18.01
4.4
3.3
—
—
—
0
0
167
809
2.15
17.99
2.0
2.4
7.11
7.45
g/l
2.20
156
731
167
809
2.15
17.99
2.0
2.4
—
—
—
0
0
1351
11292
1.48
17.93
3.7
3.1
56.43
51.59
u/l
1.05
1258
10395
404
2608
1.67
17.71
6.8
5.5
1.05
1.04
mmol/l
0.32
372
2399
1865
16730
1.62
17.39
5.5
4.8
1.99
2.04
mu/l
0.24
1734
15144
2055
18923
1.84
17.32
25.7
18.5
3.99
3.98
mmol/l
0.27
2008
18386
1597
13868
1.50
17.02
4.5
4.0
14.97
14.92
pmol/l
0.36
1471
12444
497
3408
1.59
16.98
2.1
1.8
—
—
—
0
0
156
757
2.14
16.73
2.0
2.5
2.86
3.01
g/l
1.21
145
679
332
2071
1.71
16.48
4.4
3.5
—
—
—
0
0
795
6061
1.48
16.47
4.2
3.8
15.06
9.57
mg/mmol
1.09
522
3798
765
5790
1.48
16.43
3.3
3.1
42.11
33.34
u/l
0.88
718
5492
2071
19185
1.83
16.13
15.8
10.7
25.59
25.31
u/l
0.22
2009
18426
771
5866
1.47
16.04
3.1
2.5
66.60
73.58
u/l
0.19
705
5386
88
337
2.68
16.04
1.4
1.2
28.40
50.63
u/ml
0.88
13
30
944
7479
1.45
15.83
4.7
3.9
101.19
50.86
ng/l
0.42
718
5449
127
581
2.26
15.76
1.9
2.4
0.00
0.00
g/l
-0.00
117
536
126
576
2.26
15.67
1.9
2.4
0.00
0.00
g/l
-0.00
117
535
293
1791
1.73
15.61
7.8
6.9
11.21
10.44
mmol/l
0.97
270
1703
792
6084
1.46
15.57
3.3
3.1
1788.29
1631.50
ng/l
0.40
690
5234
849
6651
1.44
14.87
3.2
3.3
2.34
2.35
mmol/l
1.32
750
5791
863
6785
1.44
14.80
4.8
3.8
106.77
118.09
e6/l
0.16
650
4879
129
613
2.17
14.60
1.9
2.4
0.02
0.02
g/l
0.04
119
566
1852
16781
1.54
14.45
7.3
6.1
41.47
40.32
mmol/mol
4.89
1726
15342
762
5885
1.44
14.27
4.3
3.3
170.97
75.12
e6/l
0.37
609
4567
115
535
2.21
13.73
1.8
1.7
—
—
—
0
0
1106
9168
1.40
13.69
4.7
3.9
0.00
0.01
estimate
1.08
204
1645
130
644
2.08
13.23
1.9
2.3
37.82
37.35
g/l
0.39
119
566
755
5885
1.42
13.21
2.6
2.1
212.85
229.13
u/l
0.17
712
5492
1094
9092
1.39
13.13
4.7
3.9
0.00
0.00
estimate
0.20
224
1826
701
5397
1.43
13.12
4.2
3.2
0.54
0.48
e6/l
0.17
556
4157
2119
19953
1.83
13.03
34.2
23.0
41.54
39.84
%
0.34
1955
18500
138
705
2.02
12.92
2.1
2.5
0.57
1.26
g/l
2.32
123
611
2119
19965
1.82
12.83
34.3
22.9
4.34
4.43
e12/l
12.41
2061
19324
355
2389
1.58
12.83
2.0
1.8
—
—
—
0
0
2119
19966
1.82
12.82
34.3
22.9
7.01
6.81
e9/l
3.64
2066
19324
2118
19956
1.82
12.78
34.3
22.9
248.44
246.93
e9/l
0.45
2064
19387
2119
19971
1.82
12.74
34.6
23.0
131.14
133.61
g/l
11.91
2083
19629
356
2402
1.57
12.72
2.0
1.7
—
—
—
0
0
559
4147
1.46
12.70
3.6
2.6
6.49
5.44
e6/l
0.74
509
3723
543
4007
1.47
12.67
2.1
1.7
1.56
1.28
mg/l
0.62
426
3077
1087
9060
1.38
12.64
6.2
5.2
0.00
0.00
estimate
0.50
210
1692
110
522
2.16
12.52
1.5
1.6
0.55
12.38
iu/ml
0.54
22
109
1718
15484
1.44
12.34
27.7
18.4
14.97
15.09
%
0.40
1689
15184
438
3139
1.49
11.75
3.1
3.1
0.81
0.82
mmol/l
0.57
404
2925
38
107
3.59
11.73
1.8
2.1
—
—
—
0
0
1908
17599
1.50
11.70
5.3
4.8
6.11
6.01
mmol/l
2.46
1762
15837
233
1451
1.67
11.49
1.8
1.6
—
—
—
0
0
58
216
2.73
11.24
1.3
1.0
6.93
1.87
u/ml
1.19
21
80
148
820
1.86
10.93
5.8
5.4
1.05
0.89
%
2.58
143
767
629
4959
1.37
9.69
3.2
2.8
4085.78
6591.41
umol/l
0.86
544
4276
1932
18021
1.46
9.67
5.3
5.1
2.58
2.66
mmol/l
3.79
1777
16410
1895
17617
1.44
9.61
4.8
4.5
4.48
4.55
mmol/l
2.46
1738
16134
331
2331
1.49
9.55
6.1
7.2
5.13
5.08
kpa
0.48
307
2216
331
2332
1.49
9.53
6.1
7.2
12.23
11.95
kpa
0.31
308
2221
401
2939
1.44
9.41
1.3
1.2
22.82
36.93
iu/ml
2.95
129
942
330
2330
1.49
9.40
6.1
7.2
1.03
1.13
mmol/l
0.16
250
1835
279
1905
1.53
9.32
4.2
3.6
1.73
2.03
mmol/l
0.59
239
1564
506
3885
1.39
9.09
4.8
3.9
203.76
380.49
ng/l
1.96
397
3185
263
1784
1.54
9.05
4.9
6.8
1.44
1.40
mmol/l
0.30
253
1737
443
3329
1.41
9.02
3.2
2.8
1.37
1.22
e6/l
0.20
268
1908
266
1819
1.52
8.82
2.4
2.5
6.38
6.71
ug/l
0.14
220
1575
602
4775
1.35
8.78
4.9
4.0
87.95
87.22
%
0.29
584
4648
278
1921
1.51
8.77
4.2
3.5
5.93
5.84
kpa
0.77
267
1862
1179
10280
1.30
8.76
2.9
2.8
—
—
—
0
0
232
1555
1.55
8.42
4.3
3.8
119.60
93.09
ng/l
1.97
200
1334
619
4957
1.34
8.42
5.2
4.2
0.00
0.00
estimate
1.28
198
1627
43
161
2.70
8.33
2.0
2.4
12.00
11.71
umol/l
0.02
34
107
1828
17012
1.37
8.16
21.1
14.7
75.47
77.39
ml/min/173m2
2.84
1537
14063
196
1284
1.58
7.87
4.1
4.0
5.26
5.17
kpa
0.79
187
1218
1867
17464
1.37
7.82
4.7
4.5
1.45
1.46
mmol/l
0.23
1707
15873
281
2001
1.46
7.61
2.4
2.1
171.66
137.09
ug/g
0.66
221
1561
396
3000
1.39
7.59
2.2
2.1
29.67
29.99
s
0.48
383
2903
153
956
1.64
7.47
4.5
3.7
23.79
24.05
mmol/l
0.33
145
933
123
725
1.74
7.46
2.7
2.3
549.06
754.98
ug/l
0.26
114
678
1015
8800
1.28
7.40
2.8
2.7
—
—
—
0
0
288
2079
1.44
7.25
6.4
7.6
95.64
95.44
%
0.22
277
1996
69
343
2.04
7.09
8.6
5.4
712.91
783.79
iu/ml
0.04
11
52
49
212
2.34
7.08
1.7
1.6
63.73
61.03
%
0.17
37
132
1804
16856
1.33
7.08
4.3
4.0
1.27
1.28
mmol/l
0.24
1641
15188
184
1226
1.54
6.88
1.6
1.5
—
—
—
0
0
183
1222
1.54
6.77
4.2
3.9
1.69
1.89
mmol/l
0.29
126
906
112
665
1.72
6.65
3.6
3.5
33.58
81.77
mg/l
1.53
89
549
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
118
711
1.70
6.65
2.8
2.8
0.40
0.35
u/ml
0.68
70
410
404
3133
1.35
6.63
3.4
3.0
2.94
2.36
e6/l
0.56
230
1721
112
666
1.72
6.62
3.6
3.4
66.23
57.95
mg/l
0.20
90
549
367
2805
1.37
6.61
1.3
1.2
4.95
13.81
u/ml
4.29
135
1046
226
1590
1.47
6.51
3.7
3.0
4.46
4.57
kpa
0.38
214
1536
105
619
1.73
6.41
1.4
1.3
—
—
—
0
0
506
4075
1.31
6.38
5.3
4.2
1.02
1.02
kg/l
0.11
76
615
132
830
1.63
6.32
2.3
1.8
2.62
2.17
ug/l
0.18
115
720
811
6943
1.26
6.27
5.2
4.1
—
—
—
0
0
474
3799
1.31
6.17
3.0
3.0
2.46
2.46
mmol/l
0.20
418
3334
107
645
1.69
6.04
3.7
3.4
1.31
1.68
ratio
—
8
50
144
937
1.57
6.00
3.3
2.5
0.87
0.65
%
3.46
144
930
260
1915
1.40
5.84
6.8
8.0
117.75
120.62
g/l
1.45
255
1858
20
60
3.35
5.72
1.2
1.1
1604.60
1687.40
miu/ml
0.09
20
60
35
144
2.45
5.70
1.1
1.1
84.40
48.50
u/ml
—
5
16
17
36
4.75
5.60
1.2
1.1
—
—
—
0
0
42
190
2.23
5.55
1.3
1.1
—
—
—
0
0
220
1599
1.42
5.34
4.9
3.7
1.23
1.23
mmol/l
0.89
199
1369
80
462
1.76
5.30
1.7
1.7
17962.13
14764.42
e6/l
0.15
61
331
207
1492
1.43
5.27
3.9
2.8
57.60
63.43
ml/min/173m2
1.48
98
625
87
517
1.71
5.22
1.3
1.5
—
—
—
0
0
156
1075
1.48
5.03
5.7
9.4
24.04
24.34
mmol/l
0.56
144
1043
183
1302
1.44
5.01
1.8
1.7
—
—
—
0
0
56
295
1.92
4.99
1.9
1.4
120.01
112.69
u/ml
0.30
14
56
77
452
1.73
4.85
1.4
1.3
—
—
—
0
0
178
1269
1.44
4.82
8.0
6.6
25.09
24.44
mmol/l
1.55
172
1200
57
307
1.88
4.77
1.3
1.2
254.99
258.98
u/ml
0.03
38
182
84
508
1.68
4.76
4.4
3.6
1.87
1.62
mg/l
1.68
78
462
75
440
1.73
4.74
2.8
2.2
126.83
128.92
g/l
0.34
64
330
58
315
1.86
4.73
4.7
3.7
0.87
1.44
%
0.84
46
273
235
1768
1.37
4.66
2.8
2.3
38.30
37.14
u/l
0.06
202
1497
50
261
1.94
4.60
4.6
6.5
11.56
11.89
mg/l
0.20
44
240
80
484
1.68
4.54
3.1
3.5
8.19
8.01
kpa
0.42
80
470
45
228
1.99
4.51
4.5
7.4
7.96
7.44
mmol/l
0.56
39
192
88
549
1.63
4.44
2.4
1.6
—
—
—
0
0
243
1852
1.35
4.44
1.7
1.7
1.63
1.49
%
1.31
196
1583
29
124
2.36
4.41
2.0
1.5
1.09
1.05
promille
0.06
23
94
59
330
1.81
4.41
1.3
1.2
—
—
—
0
0
331
2640
1.30
4.39
1.5
1.5
—
—
—
0
0
42
211
2.01
4.32
1.3
1.3
275.60
277.95
mosm/kgh2o
0.27
30
155
241
1853
1.34
4.16
4.0
2.9
188.49
219.38
ng/l
0.69
223
1695
62
361
1.74
4.07
1.1
1.2
—
316.00
—
0
10
56
318
1.78
4.01
1.5
1.4
—
—
—
0
0
68
409
1.68
3.98
2.0
2.8
31.93
34.61
umol/l
0.58
61
361
28
124
2.27
3.97
1.9
1.3
—
—
—
0
0
28
124
2.27
3.97
1.9
1.3
—
—
—
0
0
151
1086
1.42
3.94
8.3
10.0
—
—
—
0
0
75
465
1.63
3.92
1.4
1.4
—
—
—
0
0
75
465
1.63
3.92
1.4
1.4
—
—
—
0
0
80
505
1.61
3.89
1.6
1.4
—
—
—
0
0
87
561
1.57
3.87
1.5
1.4
258.86
282.91
ug/g
0.42
44
333
25
107
2.35
3.83
2.0
2.2
0.26
0.22
e9/l
0.49
16
95
301
2419
1.28
3.77
10.4
7.5
—
—
—
0
0
37
188
1.98
3.73
2.2
2.2
—
—
—
0
0
68
418
1.65
3.69
1.3
1.3
179.61
228.43
miu/ml
0.63
25
184
15
50
3.01
3.69
1.2
1.1
91.60
85.54
%
—
5
28
15
50
3.01
3.69
1.2
1.4
98.40
85.21
%
—
5
29
29
136
2.15
3.61
1.4
1.2
—
—
—
0
0
14
46
3.06
3.53
1.6
1.8
—
—
—
0
0
25
112
2.25
3.48
2.0
2.2
387.40
541.58
e6/l
0.86
15
95
24
106
2.28
3.45
1.2
1.2
—
—
—
0
0
38
202
1.90
3.39
6.9
3.5
54.63
55.99
%
0.15
30
169
29
140
2.09
3.38
1.2
1.1
221.43
156.36
titre
—
7
22
79
521
1.53
3.24
3.9
2.6
3.57
3.64
g/l
0.14
69
490
44
251
1.77
3.17
1.5
1.5
—
—
—
0
0
533
4646
1.19
3.08
2.6
2.4
—
—
—
0
0
76
503
1.53
3.08
7.4
2.5
185.87
193.74
%
0.31
69
480
99
693
1.45
3.06
2.5
2.7
—
—
—
0
0
298
2456
1.25
3.03
1.6
1.4
—
—
—
0
0
79
530
1.51
3.02
1.2
1.1
—
—
—
0
0
72
475
1.53
2.97
2.6
2.2
147.79
113.45
ug/min
0.16
36
288
549
4813
1.19
2.97
1.7
1.6
1.35
1.34
mmol/l
0.06
481
4000
22
101
2.19
2.93
1.1
1.0
—
—
—
0
0
78
526
1.50
2.92
1.2
1.2
—
—
—
0
0
31
163
1.91
2.90
1.6
1.4
31.13
29.00
%
0.10
23
103
9
22
4.10
2.88
7.9
12.4
5.83
5.65
mmol/l
—
9
22
110
797
1.40
2.83
4.9
4.4
24.65
24.84
mmol/l
0.28
104
737
26
130
2.01
2.80
1.1
1.1
—
—
—
0
0
26
130
2.01
2.80
1.1
1.1
—
—
—
0
0
74
499
1.50
2.78
3.7
3.2
0.82
0.83
nmol/l
0.11
61
388
26
131
2.00
2.75
1.1
1.1
—
—
—
0
0
26
131
2.00
2.75
1.1
1.1
—
—
—
0
0
26
131
2.00
2.75
1.1
1.1
—
—
—
0
0
116
853
1.38
2.75
2.2
1.9
—
—
—
0
0
135
1022
1.34
2.67
4.3
3.3
25.53
25.22
mmol/l
0.53
135
988
33
183
1.82
2.65
1.5
1.3
12302.29
69251.14
e6/l
0.86
17
126
63
417
1.53
2.60
4.2
2.5
15.49
16.04
%
0.59
39
213
136
1038
1.33
2.56
3.0
3.3
4.26
4.47
pmol/l
1.75
114
907
21
101
2.09
2.53
1.3
1.1
—
—
—
0
0
22
108
2.05
2.51
3.0
2.8
41.92
38.81
%
0.35
13
62
106
781
1.37
2.51
1.9
1.8
—
—
—
0
0
20
95
2.12
2.48
2.0
1.3
—
—
—
0
0
20
95
2.12
2.48
2.0
1.3
—
—
—
0
0
9
26
3.47
2.48
1.1
2.3
—
—
—
0
0
62
415
1.51
2.45
1.3
1.4
—
—
—
0
0
45
280
1.62
2.43
1.6
1.4
—
—
—
0
0
21
103
2.05
2.41
1.6
1.5
—
—
—
0
0
19
90
2.12
2.38
1.8
2.4
642.89
1377.07
u/ml
1.53
19
90
35
205
1.72
2.37
1.3
1.3
277.50
320.72
pmol/l
0.34
29
178
40
244
1.65
2.35
1.5
1.4
—
—
—
0
0
59
397
1.50
2.29
1.5
1.7
—
—
—
0
0
8
23
3.49
2.27
6.9
5.0
—
—
—
0
0
17
79
2.16
2.24
1.1
1.1
—
13.20
—
0
10
62
424
1.48
2.24
1.4
1.3
—
—
—
0
0
8
24
3.34
2.18
1.4
1.0
—
—
—
0
0
72
511
1.42
2.15
2.2
1.7
—
—
—
0
0
41
259
1.59
2.12
1.1
1.2
4.63
3.95
u/ml
0.08
16
84
62
430
1.45
2.10
1.6
1.5
—
—
—
0
0
11
43
2.57
2.08
1.0
1.1
—
—
—
0
0
72
515
1.41
2.07
1.6
1.7
—
—
—
0
0
20
103
1.95
2.05
1.7
1.5
—
—
—
0
0
15
69
2.18
2.04
1.7
3.0
36.00
104.05
umol/l
—
6
42
6
15
4.01
2.04
1.5
1.2
—
—
—
0
0
12
50
2.41
2.02
1.0
1.2
—
—
—
0
0
61
426
1.44
2.01
1.1
1.1
—
—
—
0
0
34
209
1.64
1.98
1.5
1.6
—
—
—
0
0
11
45
2.45
1.93
1.5
1.8
64.55
97.13
nmol/24h
0.76
11
45
39
250
1.57
1.93
1.2
1.2
6.53
5.33
u/ml
0.16
17
113
46
309
1.50
1.86
1.2
1.3
—
—
—
0
0
60
425
1.42
1.85
1.7
1.8
2.94
5.03
iu/l
1.20
18
140
13
59
2.21
1.84
4.5
1.7
—
—
—
0
0
22
124
1.78
1.76
1.6
1.4
—
—
—
0
0
5
13
3.85
1.71
1.4
1.2
—
—
—
0
0
107
844
1.28
1.67
1.2
1.3
—
—
—
0
0
43
292
1.48
1.67
1.6
1.4
28.56
31.47
g/l
0.88
38
262
63
462
1.37
1.63
1.8
1.6
—
—
—
0
0
17
91
1.87
1.60
3.9
3.7
—
—
—
0
0
37
246
1.51
1.60
1.3
1.4
—
—
—
0
0
684
6331
1.11
1.60
4.8
5.2
3.72
3.95
ug/l
0.05
613
5619
6
20
3.00
1.58
2.2
1.4
—
—
—
0
0
37
248
1.50
1.55
1.3
1.4
—
—
—
0
0
37
248
1.50
1.55
1.3
1.4
—
—
—
0
0
60
441
1.37
1.55
1.8
1.6
—
—
—
0
0
15
78
1.93
1.54
1.8
1.4
3.86
1.63
%
—
7
16
8
33
2.43
1.53
1.0
1.0
—
—
—
0
0
73
555
1.33
1.52
3.8
2.3
96.85
90.45
%
1.84
66
538
23
138
1.67
1.51
1.0
1.0
289.17
289.98
mg/l
0.02
23
122
36
244
1.48
1.45
1.3
1.4
—
—
—
0
0
56
413
1.36
1.43
2.1
2.2
3359.88
3056.07
u/l
0.04
20
171
38
263
1.45
1.39
1.5
1.6
—
—
—
0
0
5
17
2.95
1.36
2.4
1.7
—
—
—
0
0
46
332
1.39
1.35
1.8
1.6
—
—
—
0
0
14
75
1.87
1.34
1.3
1.1
105.13
199.26
iu/ml
1.67
14
75
23
144
1.60
1.32
1.4
1.0
—
—
—
0
0
24
152
1.59
1.31
1.6
1.5
—
—
—
0
0
17
98
1.74
1.31
3.4
3.7
—
—
—
0
0
6
24
2.50
1.30
1.2
1.1
—
—
—
0
0
11
55
2.00
1.27
1.5
1.4
—
—
—
0
0
35
244
1.44
1.25
1.3
1.4
—
—
—
0
0
19
115
1.66
1.24
2.2
2.1
74.57
105.76
ug/min
—
7
25
12
63
1.91
1.22
1.1
1.5
—
—
—
0
0
35
246
1.43
1.21
1.3
1.4
—
—
—
0
0
37
263
1.41
1.21
3.8
5.1
340.79
362.88
umol/l
0.25
29
227
20
124
1.62
1.20
1.9
1.7
—
—
—
0
0
92
747
1.24
1.20
1.7
1.9
38.05
38.77
u/l
0.12
84
652
18
109
1.66
1.18
1.2
1.4
—
—
—
0
0
18
109
1.66
1.18
1.2
1.4
—
—
—
0
0
52
393
1.33
1.18
1.3
1.5
17319.79
839.76
e6/l
0.46
43
322
52
393
1.33
1.18
1.3
1.5
21.33
30.90
e6/l
0.17
42
307
12
64
1.88
1.18
1.2
1.3
148.45
167.20
mmol/24h
0.31
12
64
8
39
2.05
1.15
1.0
1.4
—
—
—
0
0
58
448
1.30
1.14
1.4
1.4
—
—
—
0
0
16
95
1.69
1.13
1.1
1.1
—
—
—
0
0
8
40
2.00
1.12
1.0
1.1
—
—
—
0
0
8
40
2.00
1.12
2.1
1.2
—
—
—
0
0
22
143
1.54
1.11
1.1
1.6
—
—
—
0
0
31
218
1.43
1.09
1.0
1.1
6.89
5.24
u/ml
0.17
18
102
233
2073
1.14
1.08
3.7
4.0
5.13
21.20
ug/l
2.50
187
1718
7
32
2.19
1.08
1.1
1.2
—
—
—
0
0
34
244
1.40
1.07
1.1
1.1
—
—
—
0
0
30
211
1.43
1.06
1.4
1.6
—
—
—
0
0
30
211
1.43
1.06
1.4
1.6
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
17
105
1.62
1.06
1.1
1.1
—
—
—
0
0
18
113
1.60
1.05
1.3
1.8
—
—
—
0
0
24
162
1.49
1.04
1.1
1.0
—
—
—
0
0
34
246
1.39
1.03
1.1
1.1
0.62
2.42
u/ml
2.33
20
122
5
22
2.28
1.03
1.0
1.4
—
—
—
0
0
141
1215
1.17
1.03
1.9
2.2
12.21
12.18
nmol/l
0.01
127
1068
9
47
1.92
1.02
1.1
1.1
—
—
—
0
0
9
48
1.88
1.00
1.1
1.1
—
—
—
0
0
9
49
1.84
0.98
2.2
1.5
—
—
—
0
0
5
23
2.18
0.98
1.2
1.1
—
—
—
0
0
10
54
1.86
0.96
1.1
1.1
—
—
—
0
0
9
52
1.73
0.92
1.2
1.1
—
—
—
0
0
26
184
1.42
0.91
1.2
1.5
0.27
0.30
nmol/l
0.23
16
148
23
159
1.45
0.91
2.9
2.2
763.40
641.61
ml
0.56
15
102
15
94
1.60
0.90
1.2
1.1
1.11
1.10
u/l
—
5
46
22
151
1.46
0.90
1.0
1.1
24.89
3.22
u/ml
1.33
11
59
69
565
1.23
0.89
1.7
1.8
—
—
—
0
0
28
202
1.39
0.89
1.0
1.0
2.83
1.78
u/ml
0.36
19
107
41
316
1.30
0.87
1.8
1.6
—
—
—
0
0
41
316
1.30
0.87
1.8
1.6
—
—
—
0
0
12
72
1.67
0.85
1.3
1.2
—
—
—
0
0
10
57
1.76
0.83
1.0
1.1
—
—
—
0
0
22
154
1.43
0.83
2.5
1.8
3.30
4.57
mg/l
1.67
22
149
57
462
1.24
0.82
1.7
1.6
345.12
298.68
mu/l
0.60
52
419
8
46
1.74
0.82
1.3
1.2
—
—
—
0
0
6
32
1.88
0.81
1.3
1.1
—
—
—
0
0
84
712
1.19
0.79
1.8
1.9
—
—
—
0
0
104
1200
0.86
0.78
1.5
1.7
—
—
—
0
0
540
5107
1.08
0.77
4.3
4.5
22.78
21.77
%
0.80
242
2575
11
67
1.64
0.75
1.2
1.0
—
—
—
0
0
5
24
2.09
0.74
1.0
1.2
—
—
—
0
0
9
54
1.67
0.74
1.1
1.1
—
—
—
0
0
7
38
1.84
0.73
1.1
1.1
—
—
—
0
0
15
100
1.50
0.72
1.1
1.1
—
—
—
0
0
37
291
1.28
0.71
1.0
1.1
12.38
75.69
iu/ml
—
8
58
16
109
1.47
0.71
1.6
1.7
1.55
4.32
u/field
0.92
11
77
16
110
1.46
0.68
1.3
1.0
—
—
—
0
0
7
117
0.60
0.68
1.4
1.5
0.97
0.96
g/l
—
7
117
15
102
1.47
0.67
1.2
1.1
—
—
—
0
0
58
484
1.20
0.67
1.5
1.4
—
—
—
0
0
216
2354
0.91
0.67
4.9
4.6
32.76
32.99
%
0.11
147
1555
33
258
1.28
0.67
1.3
1.7
—
—
—
0
0
14
94
1.49
0.66
1.0
1.1
—
—
—
0
0
5
28
1.79
0.66
1.0
1.2
—
—
—
0
0
30
234
1.29
0.63
1.6
1.6
—
—
—
0
0
26
200
1.30
0.60
1.9
1.6
—
—
—
0
0
18
131
1.38
0.59
1.2
1.2
0.50
0.62
u/ml
0.10
11
72
6
36
1.67
0.56
1.2
1.1
—
—
—
0
0
24
186
1.29
0.54
1.2
1.1
—
—
—
0
0
21
160
1.32
0.53
1.3
1.2
—
—
—
0
0
71
811
0.87
0.52
1.0
1.0
—
—
—
0
0
30
241
1.25
0.52
1.1
1.1
127.64
115.10
%
1.03
25
220
22
170
1.30
0.51
2.3
2.3
—
—
—
0
0
11
76
1.45
0.48
1.1
1.2
—
—
—
0
0
45
383
1.18
0.46
1.4
1.4
14.64
9.84
u/l
0.94
39
301
11
77
1.43
0.45
1.6
2.3
377.33
774.85
e6/l
—
6
62
33
275
1.20
0.43
1.6
1.4
1511.35
1613.32
e6/l
0.08
23
202
31
257
1.21
0.43
1.1
1.1
—
—
—
0
0
6
92
0.65
0.42
1.7
1.4
1.36
1.54
g/l
—
6
92
8
60
1.33
0.40
1.3
1.9
—
—
—
0
0
21
169
1.24
0.38
1.0
1.0
13.39
2.68
u/ml
0.85
12
80
12
89
1.35
0.38
1.4
1.4
—
—
—
0
0
5
37
1.35
0.37
1.2
1.4
—
—
—
0
0
21
171
1.23
0.35
2.1
1.5
—
—
—
0
0
21
171
1.23
0.35
2.1
1.5
—
—
—
0
0
21
171
1.23
0.35
2.1
1.5
—
—
—
0
0
34
294
1.16
0.32
1.2
1.1
—
—
—
0
0
14
110
1.27
0.31
2.4
2.4
—
—
—
0
0
29
248
1.17
0.31
1.5
1.4
30220.62
79041.74
e6/l
0.87
13
149
116
1081
1.08
0.31
1.2
1.2
123.23
140.40
iu/ml
0.16
50
397
49
438
1.12
0.30
4.3
3.8
31.26
27.46
mg/l
0.29
35
279
32
278
1.15
0.29
1.8
1.9
198.97
197.32
pmol/l
0.03
32
264
146
1381
1.06
0.27
2.0
2.0
—
—
—
0
0
20
168
1.19
0.27
2.0
1.4
—
—
—
0
0
43
386
1.12
0.26
2.5
1.9
1.06
0.85
nmol/l
0.77
32
316
23
197
1.17
0.25
1.6
1.3
29.61
26.96
u/l
0.12
18
160
12
97
1.24
0.23
1.0
1.1
79.75
87.18
u/l
0.20
12
90
5
41
1.22
0.22
1.0
1.2
25.50
34.09
nmol/l
—
5
31
5
41
1.22
0.22
1.2
1.3
—
—
—
0
0
24
210
1.14
0.21
1.7
1.7
—
—
—
0
0
(46236287) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Pleural fluid by Immunoassay
0
12
0.00
0.21
0.0
1.1
—
3970.33
—
0
6
0
13
0.00
0.21
0.0
1.0
—
20.68
—
0
13
0
13
0.00
0.21
0.0
1.0
—
37.32
—
0
13
0
13
0.00
0.21
0.0
1.0
—
7.65
—
0
13
14
117
1.20
0.20
1.6
1.2
—
—
—
0
0
10
123
0.81
0.20
1.9
1.4
84.00
89.31
umol/l
—
10
123
0
14
0.00
0.20
0.0
2.4
—
1.18
—
0
9
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
16.11
—
0
9
7
58
1.21
0.18
1.4
2.6
—
—
—
0
0
7
58
1.21
0.18
1.4
2.6
—
—
—
0
0
24
214
1.12
0.17
1.0
1.1
—
—
—
0
0
131
1257
1.04
0.17
1.9
1.9
—
—
—
0
0
23
205
1.12
0.17
4.0
2.7
—
—
—
0
0
21
186
1.13
0.17
2.1
1.6
—
—
—
0
0
8
70
1.14
0.16
1.3
1.1
—
—
—
0
0
9
79
1.14
0.15
1.2
1.2
—
67.82
%
—
0
11
23
255
0.90
0.15
1.6
1.4
—
—
—
0
0
23
255
0.90
0.15
1.6
1.4
—
—
—
0
0
23
255
0.90
0.15
1.6
1.4
—
—
—
0
0
23
255
0.90
0.15
1.6
1.4
—
—
—
0
0
25
227
1.10
0.14
4.2
3.8
—
—
—
0
0
13
113
1.15
0.13
1.2
1.2
—
—
—
0
0
18
161
1.12
0.13
4.3
5.1
431.02
41.44
u/ml
—
6
48
13
114
1.14
0.11
1.2
1.2
—
—
—
0
0
25
271
0.92
0.11
2.5
1.7
—
—
—
0
0
25
231
1.08
0.10
1.1
1.1
—
—
—
0
0
5
46
1.09
0.09
1.0
1.1
—
—
—
0
0
10
87
1.15
0.09
1.1
1.9
—
—
—
0
0
7
64
1.09
0.08
1.1
1.2
—
—
—
0
0
7
64
1.09
0.08
1.0
1.1
—
—
—
0
0
50
480
1.04
0.08
1.5
1.5
—
—
—
0
0
18
166
1.09
0.07
1.7
1.3
—
—
—
0
0
34
325
1.05
0.06
1.6
1.5
—
—
—
0
0
59
572
1.03
0.06
1.4
1.7
4.19
4.07
mg/l
0.03
44
429
26
274
0.95
0.06
1.6
1.5
—
—
—
0
0
19
178
1.07
0.05
1.8
2.3
1.78
2.06
u/field
—
9
66
10
90
1.11
0.05
1.1
1.3
202.24
154.46
pmol/l
—
10
90
11
100
1.10
0.05
1.1
1.1
—
—
—
0
0
46
474
0.97
0.04
1.3
1.2
—
—
—
0
0
367
3643
1.01
0.04
3.0
3.2
0.84
0.77
ug/l
0.21
248
2513
57
558
1.02
0.03
1.4
1.4
28.93
28.73
iu/l
0.01
49
474
15
158
0.95
0.02
1.2
1.2
—
—
—
0
0
17
178
0.95
0.02
1.6
1.5
—
—
—
0
0
11
107
1.03
0.00
2.9
1.5
—
—
—
0
0
11
107
1.03
0.00
2.9
1.5
—
—
—
0
0
17
173
0.98
0.00
1.3
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
12.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
84
0.95
-0.00
3.6
1.6
—
—
—
0
0
8
83
0.96
-0.00
3.6
1.6
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
25.60
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
7.70
—
0
7
8
83
0.96
-0.00
3.6
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_BULLOUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOUS | 1.614 [1.43, 1.82] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.267 |
During the follow-up period (1.1.1998 — 31.12.2019), 2522 out of 7359 females with L12_BULLOUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_BULLOUS | 1.855 [1.6, 2.15] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 2107 out of 5767 males with L12_BULLOUS died.
Mortality risk
Mortality risk for people of age
years, who have L12_BULLOUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.413% |
| 5 | 0.867% | 2.001% |
| 10 | 2.293% | 4.857% |
| 15 | 4.463% | 8.924% |
| 20 | 7.786% | 14.77% |
Relationships between endpoints
↥Index endpoint: L12_BULLOUS – Bullous disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data