pemphigus: a rare group of blistering autoimmune diseases that affect the skin and mucous membranes.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
227 |
4. Check minimum number of eventsNone |
227 |
5. Include endpoints |
251 |
6. Filter based on genotype QC (FinnGen only) |
238 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L10-L14
- Name in latin
- Pemphigus
Similar endpoints
↥List of similar endpoints to
Pemphigus
based on the number of shared cases.
Similar with more cases:
- Bullous disorders
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2071 | 1164 | 893 |
| Only index persons | 1659 | 955 | 704 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 60.97 | 62.71 | 58.53 |
| Only index persons | 58.01 | 59.23 | 56.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 238 | 128 | 110 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | 57.40 | 53.32 | 62.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 251
- Matched controls
- 2510
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
84.2
76
*
L10.0
ICD-10 Finland
Pemphigus vulgaris
1098.9
83.5
77
*
L04AX01
ATC
azathioprine; systemic
17.9
53.3
46
31
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.2
48.9
80
135
L10.2
ICD-10 Finland
Pemphigus foliaceus
+∞
39.6
37
*
L10.8
ICD-10 Finland
Other pemphigus
+∞
35.2
33
*
D07AD01
ATC
clobetasol; topical
5.3
33.0
89
236
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
5.2
28.4
72
179
L12.0
ICD-10 Finland
Bullous pemphigoid
+∞
27.6
26
*
L10.4
ICD-10 Finland
Pemphigus erythematosus
+∞
26.5
25
*
H02AB06
ATC
prednisolone; systemic
3.9
23.5
171
885
J04BA02
ATC
dapsone; oral
132.1
23.0
24
*
135
Kela drug reimbursment
Pemphigus
+∞
22.2
21
*
D07AC01
ATC
betamethasone; topical
3.6
22.2
136
623
L04AX03
ATC
methotrexate; systemic
4.4
17.2
49
131
L10.1
ICD-10 Finland
Pemphigus vegetans
+∞
16.9
16
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.4
16.7
77
287
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
15.5
120
599
69400
ICD-8 Finland
Pemphigus, Vulgaris, vegetans, foliaceus
+∞
13.7
13
*
D07AB08
ATC
desonide; topical
3.6
13.1
50
163
D07AC13
ATC
mometasone; topical
2.8
13.0
93
438
D07BA04
ATC
hydrocortisone and antiseptics; topical
4.1
12.9
39
108
L40.0
ICD-10 Finland
Psoriasis vulgaris
5.9
11.9
22
40
XQ848
NOMESCO Finland
Dermatological photography
6.1
11.7
21
37
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.3
11.0
23
47
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
12.0
10.7
19
17
E0000UV, ,
ATC
2.4
10.7
124
722
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.1
9.9
47
174
D07AB02
ATC
hydrocortisone butyrate; topical
2.4
9.5
92
488
E000001, ,
ATC
2.6
9.2
65
298
TQW80
NOMESCO Finland
Local dermatologic skincare
8.0
9.1
20
27
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
8.8
56
243
L04AA06
ATC
mycophenolic acid; systemic
10.6
8.7
16
16
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.2
8.6
132
842
L13.9
ICD-10 Finland
Bullous disorder, unspecified
93.1
8.5
9
*
L10
ICD-10 Finland
Pemphigus
+∞
8.4
8
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
4.5
8.1
20
47
SBA00
NOMESCO Finland
Microbiological examinations
8.2
8.0
17
22
D07CC01
ATC
betamethasone and antibiotics; topical
2.7
8.0
47
195
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.3
7.7
69
350
L30.0
ICD-10 Finland
Nummular dermatitis
4.5
7.3
18
42
L10.3
ICD-10 Finland
Brazilian pemphigus [fogo selvagem]
+∞
7.3
7
*
ECA20
NOMESCO Finland
Biopsy of gingiva
14.3
7.0
11
8
L12.9
ICD-10 Finland
Pemphigoid, unspecified
41.2
6.8
8
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
6.7
23
69
D07XC01
ATC
betamethasone; topical
2.6
6.7
43
186
K13.78
ICD-10 Finland
Other change in the oral mucosa
8.2
6.7
14
18
Z3231
NOMESCO Finland
Registered nurse
2.1
6.6
83
480
J01FF01
ATC
clindamycin; systemic
2.1
6.4
79
453
Q82.80
ICD-10 Finland
Benign familial pemphigus [Hailey-Hailey]
+∞
6.3
6
*
L12.8
ICD-10 Finland
Other pemphigoid
+∞
6.3
6
*
L30.3
ICD-10 Finland
Infective dermatitis
4.3
6.2
16
39
S97
ICPC
Chronic ulcer skin
3.1
6.2
27
95
J33.0
ICD-10 Finland
Polyp of nasal cavity
7.0
6.1
14
21
H02AB07
ATC
prednisone; oral
2.4
6.1
44
201
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
9
75.89
48.60
1.8
1.1
19.25
—
u/ml
—
16
0
155
939
2.70
13.03
12.1
6.0
26.15
27.79
%
1.15
146
884
150
929
2.53
11.51
11.7
5.8
59.15
57.29
%
1.13
142
877
172
1183
2.44
9.80
14.9
9.2
4.31
4.23
e9/l
0.19
154
1047
41
163
2.81
7.56
1.9
2.8
66.98
66.18
g/l
0.35
36
154
36
153
2.58
5.80
9.5
6.5
11.09
9.93
mmol/l
0.47
36
147
138
1004
1.83
5.22
7.7
6.0
1.20
1.21
mmol/l
0.87
120
867
82
509
1.91
5.13
2.8
1.9
2.56
3.11
mg/l
1.89
73
434
17
52
3.43
4.84
1.8
1.4
—
—
—
0
0
33
151
2.36
4.55
2.8
2.9
53.00
62.88
ml/min/173m2
0.67
14
59
23
88
2.78
4.54
2.2
2.0
—
—
—
0
0
184
1509
1.82
4.24
5.6
4.1
14.78
12.12
mm/h
1.42
170
1378
124
911
1.71
4.24
7.3
5.2
1.21
1.21
mmol/l
0.30
115
836
43
228
2.07
4.15
1.7
1.8
—
—
—
0
0
39
203
2.09
3.95
5.2
3.5
—
—
—
0
0
41
222
2.01
3.74
1.8
1.8
—
—
—
0
0
54
322
1.86
3.72
1.8
1.9
—
—
—
0
0
139
1080
1.64
3.65
6.0
6.2
10.58
11.08
umol/l
0.35
132
1018
10
21
4.91
3.59
1.8
1.1
—
—
—
0
0
46
263
1.92
3.59
3.8
2.5
19.92
22.45
%
0.61
40
231
62
394
1.76
3.45
2.0
1.7
1250.25
1241.88
nmol/l
0.02
53
299
186
1573
1.70
3.37
10.3
7.3
76.81
77.21
u/l
0.04
178
1469
14
49
2.97
3.24
1.9
1.3
—
—
—
0
0
28
139
2.14
3.20
2.8
2.5
137.80
206.11
ng/l
0.75
28
124
116
882
1.59
3.19
4.8
4.2
33.59
35.62
g/l
2.82
108
835
64
432
1.65
2.82
2.5
1.8
3.51
1.21
mg/l
0.87
50
344
8
18
4.55
2.82
1.5
1.4
—
—
—
0
0
72
505
1.60
2.71
1.8
1.6
18.49
21.35
nmol/l
0.94
67
426
121
954
1.52
2.70
11.9
13.8
1.24
1.25
inr
0.03
38
271
56
372
1.65
2.62
3.6
3.6
454.76
133.85
ng/l
0.78
45
291
12
44
2.81
2.58
1.2
1.4
—
—
—
0
0
12
44
2.81
2.58
1.2
1.4
—
—
—
0
0
37
220
1.80
2.56
1.6
2.7
4.97
8.88
umol/l
2.13
31
192
146
1214
1.48
2.42
6.3
4.2
6.91
6.64
mmol/l
0.84
135
1123
7
17
4.20
2.37
1.1
1.1
—
—
—
0
0
106
832
1.47
2.33
2.3
2.0
96.70
94.37
pmol/l
0.18
62
434
9
28
3.29
2.33
1.4
1.4
—
—
—
0
0
13
54
2.48
2.23
1.8
1.3
—
—
—
0
0
5
9
5.64
2.22
2.0
2.3
—
—
—
0
0
104
823
1.45
2.15
2.1
2.2
74.43
77.12
nmol/l
0.54
94
728
10
37
2.77
2.09
6.9
2.6
6.03
4.93
e9/l
—
10
37
108
866
1.43
2.06
3.8
2.6
148.13
115.92
ug/l
1.08
101
792
10
38
2.70
2.03
8.6
3.1
63.50
58.82
%
—
10
38
61
439
1.51
2.01
2.0
1.8
433.50
448.29
pmol/l
0.16
54
365
120
984
1.42
2.01
4.6
3.9
0.00
0.00
estimate
0.50
26
203
15
71
2.18
1.96
2.7
2.6
—
—
—
0
0
70
521
1.48
1.96
5.5
4.2
0.00
0.00
estimate
-0.00
22
184
59
424
1.51
1.96
1.4
1.2
0.82
1.83
u/ml
1.07
13
113
9
33
2.79
1.95
1.4
1.7
—
—
—
0
0
50
347
1.55
1.94
1.3
1.3
23.85
33.55
iu/ml
0.53
13
118
121
1000
1.41
1.91
4.6
3.9
0.00
0.00
estimate
-0.00
26
181
12
52
2.37
1.91
1.6
1.2
—
—
—
0
0
15
72
2.15
1.90
1.2
1.9
—
—
—
0
0
7
22
3.24
1.89
1.1
1.1
—
—
—
0
0
119
986
1.39
1.83
5.5
5.3
0.00
0.00
estimate
-0.00
25
190
86
674
1.42
1.82
2.8
3.3
2.32
2.35
mmol/l
2.04
79
596
11
47
2.40
1.80
1.1
1.2
—
1.03
—
0
6
24
141
1.78
1.75
1.9
1.5
—
—
—
0
0
8
31
2.63
1.67
1.3
1.7
—
—
—
0
0
6
19
3.21
1.67
1.0
1.2
—
—
—
0
0
5
14
3.62
1.62
1.8
1.4
—
—
—
0
0
69
534
1.40
1.55
3.5
2.9
6090.74
10032.53
umol/l
0.27
62
463
93
758
1.36
1.52
5.0
3.2
—
—
—
0
0
28
180
1.63
1.51
6.5
5.1
1.29
1.33
mmol/l
0.10
28
172
215
2003
1.51
1.49
22.6
14.5
24.49
23.21
mg/l
0.24
187
1590
9
37
2.48
1.49
1.3
1.7
—
—
—
0
0
78
621
1.37
1.47
4.7
3.7
22.23
8.16
mg/mmol
0.62
52
385
75
595
1.37
1.45
5.0
3.2
0.68
0.40
e6/l
0.50
62
449
12
60
2.05
1.40
1.3
1.7
—
—
—
0
0
20
121
1.71
1.35
1.4
1.5
—
—
—
0
0
9
44
2.08
1.28
1.7
1.4
—
—
—
0
0
9
45
2.04
1.24
1.4
1.6
—
—
—
0
0
8
38
2.14
1.19
1.8
1.4
—
—
—
0
0
30
210
1.49
1.15
1.7
1.7
1.56
1.55
%
0.03
25
189
10
51
2.00
1.13
1.7
1.4
146.80
273.93
ug/g
—
5
26
9
165
0.53
1.12
1.1
1.7
—
—
—
0
0
5
21
2.41
1.09
1.0
1.5
—
—
—
0
0
77
638
1.30
1.08
3.8
2.3
51.38
63.32
u/l
0.92
71
595
10
52
1.96
1.07
1.1
1.3
—
—
—
0
0
7
33
2.15
1.06
1.1
1.2
238.57
244.67
u/ml
—
7
21
135
1204
1.26
1.04
3.0
2.9
—
—
—
0
0
9
47
1.95
1.03
1.4
1.6
—
—
—
0
0
199
1864
1.33
1.02
6.6
5.9
41.05
40.13
mmol/mol
0.63
191
1726
165
1510
1.27
1.01
4.1
3.9
14.70
14.79
pmol/l
0.18
151
1360
7
35
2.03
1.01
1.1
1.2
—
—
—
0
0
43
331
1.36
1.00
1.3
1.3
22.61
9.53
u/ml
0.58
15
126
9
49
1.87
0.99
1.3
1.1
—
—
—
0
0
223
2129
1.43
0.98
17.7
10.3
24.99
25.11
u/l
0.05
215
2049
46
360
1.34
0.97
3.7
2.9
0.96
0.87
e6/l
0.12
29
203
31
230
1.40
0.90
8.9
5.3
-0.60
1.19
mmol/l
0.61
23
188
6
29
2.09
0.90
1.3
1.7
—
—
—
0
0
18
120
1.54
0.88
1.7
1.7
—
—
—
0
0
6
30
2.02
0.87
2.7
1.2
—
106.71
—
0
7
8
46
1.76
0.83
1.0
1.3
—
—
—
0
0
6
32
1.90
0.82
1.3
1.7
—
—
—
0
0
6
32
1.90
0.82
1.0
1.1
—
—
—
0
0
49
404
1.26
0.72
2.4
2.9
2.44
2.46
mmol/l
0.51
44
357
219
2109
1.30
0.67
28.2
17.1
80.15
78.42
umol/l
0.36
219
2109
5
28
1.80
0.66
1.4
1.2
—
—
—
0
0
194
1847
1.22
0.64
4.9
4.7
1.91
1.93
mu/l
0.10
179
1676
6
104
0.57
0.63
1.0
1.0
—
—
—
0
0
25
194
1.32
0.58
3.8
3.7
5.82
5.68
kpa
0.33
25
186
8
54
1.50
0.58
2.8
1.4
—
—
—
0
0
49
568
0.83
0.53
4.8
4.4
21.72
21.76
%
0.01
19
276
60
524
1.19
0.52
1.8
1.6
1.64
1.37
mmol/l
0.97
48
435
198
1902
1.19
0.51
22.9
13.7
76.86
79.96
ml/min/173m2
1.02
169
1577
7
45
1.57
0.49
1.3
1.4
—
—
—
0
0
85
770
1.16
0.48
5.1
4.0
—
—
—
0
0
36
424
0.82
0.46
3.4
3.1
0.81
0.75
ug/l
0.08
19
266
226
2208
1.24
0.41
34.7
21.2
256.01
247.78
e9/l
0.92
219
2156
38
326
1.20
0.41
1.9
1.5
—
—
—
0
0
16
204
0.77
0.41
1.7
2.1
—
—
—
0
0
8
61
1.32
0.40
1.3
1.2
—
—
—
0
0
226
2210
1.23
0.39
35.1
21.2
39.78
40.05
%
0.29
213
2088
226
2210
1.23
0.39
34.8
21.2
4.39
4.47
e12/l
1.57
219
2154
40
347
1.18
0.39
3.7
3.0
1.98
1.98
e6/l
0.00
22
192
87
801
1.13
0.38
4.0
3.9
70.99
38.23
ng/l
0.52
64
578
8
112
0.70
0.38
2.0
2.7
1.16
1.28
%
—
8
112
15
188
0.79
0.34
1.8
1.9
—
—
—
0
0
7
56
1.26
0.29
1.1
1.6
—
—
—
0
0
8
62
1.30
0.28
1.3
1.2
—
—
—
0
0
33
294
1.14
0.24
1.2
1.5
—
—
—
0
0
9
77
1.18
0.24
2.3
2.1
—
—
—
0
0
5
38
1.32
0.23
11.2
2.3
16.72
16.21
%
—
5
19
5
41
1.22
0.22
1.6
1.2
160.60
165.87
e6/l
—
5
30
5
41
1.22
0.22
1.6
1.1
19.40
21.43
e6/l
—
5
28
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
4.3
—
215.91
—
0
11
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.9
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
192
1881
1.09
0.19
4.1
4.1
1.35
1.27
mmol/l
1.01
177
1713
101
967
1.07
0.19
3.0
2.5
—
—
—
0
0
29
264
1.11
0.16
9.7
5.5
102.38
103.62
mmol/l
0.54
29
264
13
151
0.85
0.16
2.6
2.4
—
18.80
—
0
6
8
73
1.10
0.16
1.9
1.9
—
—
—
0
0
199
1962
1.07
0.13
4.5
4.5
4.65
4.60
mmol/l
0.25
185
1810
198
1952
1.07
0.13
4.5
4.5
1.44
1.47
mmol/l
0.41
185
1786
68
709
0.94
0.12
4.7
5.0
1.84
2.68
ug/l
0.75
59
628
11
95
1.17
0.12
1.3
1.4
—
—
—
0
0
5
44
1.14
0.10
1.6
1.7
—
—
—
0
0
192
1939
0.96
0.07
4.7
4.7
6.06
5.97
mmol/l
0.42
180
1768
12
108
1.12
0.07
3.3
2.6
1.04
0.67
%
0.72
12
108
7
81
0.86
0.07
1.6
1.8
—
—
—
0
0
7
85
0.82
0.07
1.6
1.6
—
—
—
0
0
11
102
1.08
0.03
1.8
1.9
—
—
—
0
0
16
167
0.96
0.01
2.8
3.0
4.03
4.46
kpa
0.53
16
157
24
242
0.99
0.00
10.6
7.6
—
—
—
0
0
48
484
0.99
0.00
3.4
2.3
—
—
—
0
0
201
2005
1.01
0.00
5.1
5.1
2.70
2.71
mmol/l
0.01
188
1837
13
134
0.97
0.00
1.5
1.2
127.67
148.28
iu/ml
—
6
53
5
59
0.84
0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
10.56
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
1.18
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.8
—
66.03
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PEMPHIGUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGUS | 1.626 [1.33, 1.99] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.595 |
During the follow-up period (1.1.1998 — 31.12.2019), 277 out of 914 females with L12_PEMPHIGUS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGUS | 1.956 [1.45, 2.64] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 244 out of 706 males with L12_PEMPHIGUS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PEMPHIGUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.394% |
| 5 | 1.082% | 2.301% |
| 10 | 2.535% | 5.646% |
| 15 | 4.777% | 10.27% |
| 20 | 8.552% | 17.108% |
Relationships between endpoints
↥Index endpoint: L12_PEMPHIGUS – Pemphigus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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