Pemphigus vulgaris

L12_PEMPHIGUS_VULG

pemphigus vulgaris: Pemphigus vulgaris is a rare chronic blistering skin disease and the most common form of pemphigus.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L10.0 Hospital discharge: ICD-9 — 6944A Cause of death: ICD-10 — L10.0 Cause of death: ICD-9 — 6944A 2 out of 7 registries used, show all original rules.	78
4. Check minimum number of events None	78
5. Include endpoints None	78
6. Filter based on genotype QC (FinnGen only)	75

Control definitions (FinnGen only)

Control exclude: L12_BULLOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L10
Name in latin: Pemphigus vulgaris

NAME	L12_PEMPHIGUS_VULG
CONTROL_EXCLUDE	L12_BULLOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L100
HD_ICD_9	6944A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L100
COD_ICD_9	6944A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pemphigus vulgaris based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	640	359	278
Only index persons	523	299	224
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	60.66	64.02	56.61
Only index persons	57.85	60.55	54.25

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	75	47	28
Unadjusted period prevalence (%)	0.02	0.02	0.01
Median age at first event (years)	60.68	57.79	65.53

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
78: Matched controls
780

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L10.0

ICD-10 Finland

Pemphigus vulgaris

8366.9

104.8

D07AD01

ATC

clobetasol; topical

6.9

14.9

L04AX01

ATC

azathioprine; systemic

26.3

14.7

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

6.1

10.8

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

6.7

10.2

135

Kela drug reimbursment

Pemphigus

+∞

9.6

L12.0

ICD-10 Finland

Bullous pemphigoid

+∞

9.6

J04BA02

ATC

dapsone; oral

+∞

9.6

L10.9

ICD-10 Finland

Pemphigus, unspecified

+∞

9.6

L10.8

ICD-10 Finland

Other pemphigus

+∞

8.5

H02AB06

ATC

prednisolone; systemic

4.0

7.8

271

D07XC01

ATC

betamethasone; topical

4.6

6.9

ECA20

NOMESCO Finland

Biopsy of gingiva

75.8

6.5

K13.79

ICD-10 Finland

Change in the oral mucosa UNS

16.7

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

+∞

13.96

1.2

0.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

285

4.42

8.56

14.3

6.0

—

(3022096) Basophils/100 leukocytes in Blood

284

4.18

8.06

12.9

5.8

0.65

0.63

0.10

259

(3006504) Eosinophils/100 leukocytes in Blood

290

4.04

7.68

13.0

5.8

3.29

2.69

0.82

265

(3019069) Monocytes/100 leukocytes in Blood

293

3.97

7.49

13.2

6.2

8.57

8.32

0.33

268

(3002030) Lymphocytes/100 leukocytes in Blood

299

3.85

7.14

13.1

6.0

25.82

27.08

0.41

275

(3018010) Neutrophils/100 leukocytes in Blood

296

3.68

6.79

12.4

5.7

59.38

58.23

0.32

272

(3021589) Normoblasts [#/volume] in Blood

259

2.74

4.55

15.2

8.6

0.00

e9/l

0.50

205

(40768443) Skin Pathology biopsy report

4.64

4.37

1.3

1.4

—

(3023368) Bacteria identified in Blood by Culture

162

2.65

4.08

7.2

4.3

—

(46236952) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)

4.12

3.71

2.6

3.6

56.29

67.62

ml/min/173m2

—

(3033658) Prothrombin time (PT) actual/Normal

164

2.48

3.53

7.7

3.8

93.06

92.44

0.06

159

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

5.50

3.49

1.3

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

5.50

3.49

1.3

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

3.14

3.38

4.3

3.3

—

(3036489) Thrombin time

6.86

3.26

7.1

1.5

24.00

20.64

—

(3004588) Protein electrophoresis panel - Serum or Plasma

3.27

3.20

1.5

1.3

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

298

2.21

2.91

10.0

6.4

1.22

mmol/l

0.25

256

(3043723) Beta 1 globulin [Mass/volume] in Serum or Plasma by Electrophoresis

3.94

2.90

1.4

1.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.66

2.82

1.5

1.7

—

(3030905) Polymorphonuclear cells [#/volume] in Blood

8.79

2.79

6.6

3.2

5.54

5.24

e9/l

—

(3032035) Polymorphonuclear cells/100 leukocytes in Blood

8.79

2.79

6.8

3.5

61.60

57.83

—

(40758558) Short blood count panel - Blood

157

2.22

2.69

11.9

6.8

—

(3023520) Reticulocytes [#/volume] in Blood

2.97

2.59

4.3

3.2

81.89

77.39

e9/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.47

2.2

1.5

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.50

2.41

1.6

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

5.85

2.24

22.6

2.6

153.00

148.56

—

(3042936) Bacteria identified in Isolate by Culture

2.27

2.24

2.8

2.1

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.25

2.23

6.2

8.0

0.63

0.66

—

(3000494) Fungus identified in Specimen by Culture

2.34

2.21

3.1

1.4

—

(3037756) Immunofixation for Serum or Plasma

4.55

2.19

1.0

1.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

106

2.19

2.16

1.6

1.9

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.15

2.15

6.2

7.8

1.20

1.67

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

131

2.07

3.0

3.1

—

(36304997) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ and CD8+ T-cells [Units/volume] in Blood

3.55

2.01

1.6

1.3

—

0.00

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

109

2.12

2.01

3.5

3.1

42.87

73.58

ng/l

0.30

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

4.77

1.97

1.2

1.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.39

1.93

1.0

1.3

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.69

1.80

1.6

1.8

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

3.52

1.78

1.3

1.1

0.19

0.26

g/l

—

(3052851) Hemolysis interference index of Serum or Plasma

3.52

1.78

4.3

3.2

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

3.52

1.78

1.2

1.1

0.97

1.27

g/l

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

2.40

1.78

1.8

2.1

401.00

402.73

nmol/l

0.01

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.10

1.77

1.6

7.6

22.20

25.76

mmol/l

—

(3003694) ABO and Rh group [Type] in Blood

163

1.89

1.77

1.4

—

(3018418) pH of Serum or Plasma

189

1.85

1.75

9.3

3.8

7.39

7.40

—

(3037467) Urinalysis macro (dipstick) panel - Urine

426

1.87

1.74

7.2

4.2

—

(3018095) Leukocytes [#/volume] in Urine

216

1.82

1.72

5.7

3.9

84.81

64.19

e6/l

0.18

146

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.11

1.70

11.6

4.5

1.03

1.04

mmol/l

0.04

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

140

1.91

1.70

3.4

1.9

5.36

1.35

mg/l

0.48

114

(3024891) Influenza virus A+B Ag [Presence] in Specimen

3.16

1.61

1.3

—

(3027945) Reticulocytes/100 erythrocytes in Blood

2.13

1.48

4.4

3.4

2.19

1.85

0.61

(3009261) Glucose [Presence] in Urine by Test strip

298

1.70

1.48

3.4

3.5

0.00

estimate

—

(3021601) Nitrite [Presence] in Urine by Test strip

292

1.67

1.40

5.0

4.9

0.00

estimate

—

(40761536) Microorganisms panel - Urine sediment

2.29

1.39

4.1

3.3

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

246

1.68

1.38

2.1

1.9

101.73

94.19

pmol/l

0.42

116

(3035350) Ketones [Presence] in Urine by Test strip

293

1.66

1.37

3.5

0.00

estimate

—

(3012544) pH of Venous blood

2.24

1.34

4.6

4.1

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

2.50

1.33

3.9

7.6

—

(1761868) Lipid panel - Serum or Plasma

216

0.52

1.31

2.2

2.9

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.89

1.30

1.4

2.1

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.89

1.30

2.0

1.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

205

1.66

1.27

5.3

3.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.74

1.23

1.4

1.5

—

(3002434) Lupus erythematosus deoxynucleoproteins IgG Ab [Units/volume] in Serum by Immunoassay

2.74

1.23

1.2

1.3

—

(3003284) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum by Immunofluorescence

2.47

1.10

1.2

1.5

—

(40768797) Stomach Pathology biopsy report

1.80

1.10

1.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

203

1.59

1.09

3.6

3.3

28.50

31.44

u/l

0.27

192

(3000991) Gas panel - Venous blood

2.08

1.08

5.9

7.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

100

1.75

1.07

4.6

2.6

2.56

1.92

e6/l

—

(3007164) IgA [Mass/volume] in Serum or Plasma

125

1.69

1.07

2.0

1.5

2.06

2.17

g/l

0.15

(36304419) Bacteria [Presence] in Urine

169

1.61

1.04

5.4

3.1

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.83

1.03

2.8

1.5

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

625

1.90

1.02

22.4

14.4

25.94

22.01

mg/l

0.34

492

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.32

0.96

1.2

1.3

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.82

0.95

6.9

6.5

102.42

103.61

mmol/l

0.30

(3002385) Erythrocyte distribution width [Ratio]

539

1.60

0.91

34.5

17.4

14.16

15.22

1.40

534

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

105

1.66

0.90

4.6

2.5

1.07

0.97

e6/l

—

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

597

1.69

0.86

26.3

13.5

76.70

81.32

ml/min/173m2

0.82

473

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.48

0.85

5.4

4.4

31.00

33.62

—

(3031040) Bacteria [#/volume] in Urine by Automated count

418

1.46

0.83

5.9

4.4

—

66.85

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.25

0.77

2.6

2.2

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

119

1.55

0.75

2.8

1.8

—

(3019060) Gas panel - Arterial blood

1.87

0.75

8.1

3.9

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.65

0.74

1.7

1.5

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.07

0.74

1.2

1.1

—

(3022217) INR in Platelet poor plasma by Coagulation assay

286

1.41

0.72

5.2

12.8

1.15

1.27

inr

0.40

(3019550) Sodium [Moles/volume] in Serum or Plasma

653

1.70

0.71

26.7

15.6

139.31

139.78

mmol/l

0.68

634

(3012516) Albumin [Mass/volume] in Urine

177

1.42

0.65

4.5

3.3

3410.24

38.62

mg/l

0.48

101

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.54

0.64

2.9

1.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

665

1.75

0.63

30.3

16.8

80.18

75.43

umol/l

0.60

665

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.61

0.0

1.5

—

44.15

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

0.00

0.61

0.0

6.3

—

30.61

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.55

0.60

10.4

5.8

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

0.60

0.0

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

296

1.33

0.55

2.9

2.7

—

(3029937) Albumin [Presence] in Urine by Test strip

147

1.39

0.52

3.7

3.4

0.00

estimate

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.61

0.50

1.4

1.6

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

270

1.31

0.50

2.4

2.3

77.67

76.75

nmol/l

0.07

239

(3044889) 12 lead EKG panel

433

1.28

0.44

3.5

3.6

—

(40761511) CBC panel - Blood by Automated count

666

1.50

0.40

20.1

13.0

—

(3023103) Potassium [Moles/volume] in Serum or Plasma

655

1.46

0.38

26.9

15.7

3.96

3.97

mmol/l

0.19

636

(40768804) Tissue Pathology biopsy report

280

1.24

0.36

2.5

2.1

—

(3002256) Pathology report gross observation

0.68

0.35

1.5

1.2

—

(3044640) Blood type and Crossmatch panel - Blood

205

1.25

0.33

3.0

2.5

—

(21494755) Public health laboratory ask at order entry panel

1.41

0.32

1.0

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

149

1.27

0.31

3.4

2.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

187

1.25

0.31

4.6

3.8

14.09

6.26

mg/mmol

0.54

104

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

131

1.28

0.30

2.2

1.8

374.00

452.41

pmol/l

0.79

111

(3019832) Treponema pallidum Ab [Presence] in Serum

1.24

0.28

1.3

1.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

181

1.22

0.26

3.2

2.8

17265.90

4095.98

umol/l

0.35

147

(3007461) Platelets [#/volume] in Blood

699

1.39

0.25

37.2

20.9

255.79

252.83

e9/l

0.16

684

(3000963) Hemoglobin [Mass/volume] in Blood

700

1.37

0.25

37.3

20.9

131.93

135.03

g/l

1.10

690

(3024731) MCV [Entitic volume]

700

1.37

0.25

37.1

20.7

92.04

90.94

1.08

690

(3026361) Erythrocytes [#/volume] in Blood

700

1.37

0.25

37.1

20.8

4.36

4.48

e12/l

1.32

684

(3035941) MCH [Entitic mass]

700

1.37

0.25

37.0

20.7

30.45

30.25

0.43

690

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(3023150) Myeloperoxidase Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.8

—

(3030408) 3-Methoxytyramine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

2.9

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.21

0.0

1.2

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(3003191) Choriogonadotropin (pregnancy test) [Presence] in Serum or Plasma

0.00

0.21

0.0

1.6

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.21

0.0

1.1

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.21

0.0

1.6

—

22.38

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

(4200892) Spirometry reversibility

1.27

0.21

2.2

1.6

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

224

1.17

0.20

3.4

—

(3019225) pH of Specimen

1.18

0.17

5.1

4.8

—

(3010813) Leukocytes [#/volume] in Blood

701

1.35

0.16

37.0

20.8

7.20

6.61

e9/l

1.34

684

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

139

0.84

0.15

2.2

5.5

25.46

20.85

—

(3026008) Bacteria identified in Urine by Culture

190

1.14

0.14

5.6

2.9

—

(40761535) Cells panel - Urine sediment

1.15

0.10

3.4

3.3

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.10

0.09

2.0

1.8

—

(3000492) Spirometry study

1.08

0.09

2.0

1.6

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.82

0.08

1.6

1.5

—

(4035726) Immunohistochemistry procedure

1.12

0.08

1.9

1.3

—

(3013512) EKG study

193

0.91

0.07

3.2

4.1

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

397

1.07

0.06

3.1

3.2

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

111

1.10

0.04

1.7

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

112

1.08

0.03

1.2

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

164

1.05

0.00

3.7

3.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

256

0.97

0.00

3.2

3.9

19.23

38.62

ng/l

0.84

170

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

629

1.01

0.00

3.9

4.6

1.43

1.52

mmol/l

1.01

573

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

1.8

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.1

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.2

—

(3019897) Erythrocyte distribution width [Ratio] by Automated count

0.00

-0.00

0.0

1.2

—

14.00

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

37.40

—

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

-0.00

0.0

2.0

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

21.10

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.92

-0.00

1.3

1.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

239.22

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

2.2

—

(3016914) Bacteria identified in Cerebral spinal fluid by Culture

0.00

-0.00

0.0

1.0

—

(3019230) Fractional oxyhemoglobin in Venous blood

0.00

-0.00

0.0

3.3

—

52.67

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.00

-0.00

2.0

2.1

—

(3025547) Thyroglobulin Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

3.0

—

6.44

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.6

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3027456) Digoxin [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

0.69

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

3.19

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

7.0

—

214.67

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.0

—

(36660697) Celiac disease serology panel - Serum

0.87

-0.00

1.2

1.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

-0.00

0.0

1.5

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

3.9

—

(3051593) INR in Capillary blood by Coagulation assay

0.00

-0.00

0.0

4.6

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

3.4

—

125.30

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.7

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.1

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

4.3

—

(3022145) Colonoscopy Study observation

0.89

-0.00

1.1

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.8

—

12.98

—

(40768806) Pleura Pathology biopsy report

0.00

-0.00

0.0

1.4

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.8

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

2.0

—

44.26

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PEMPHIGUS_VULG and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_PEMPHIGUS_VULG	1.752 [1.25, 2.45]	0.001
Birth year	0.994 [0.99, 1.0]	0.182

During the follow-up period (1.1.1998 — 31.12.2019), 90 out of 304 females with L12_PEMPHIGUS_VULG died.

Males

Parameter	HR [95% CI]	p-value
L12_PEMPHIGUS_VULG	1.904 [1.16, 3.12]	0.011
Birth year	0.989 [0.98, 1.0]	0.017

During the follow-up period (1.1.1998 — 31.12.2019), 77 out of 246 males with L12_PEMPHIGUS_VULG died.

Mortality risk

Mortality risk for people of age

years, who have L12_PEMPHIGUS_VULG.

N-year risk	Females	Males
1	0.16%	0.421%
5	0.95%	2.362%
10	2.56%	5.591%
15	4.683%	10.843%
20	8.381%	17.73%

Relationships between endpoints

↥

Index endpoint: L12_PEMPHIGUS_VULG – Pemphigus vulgaris

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pemphigus vulgaris

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints