dermatitis herpetiformis: Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
672 |
4. Check minimum number of eventsNone |
672 |
5. Include endpointsNone |
672 |
6. Filter based on genotype QC (FinnGen only) |
661 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L13
- Name in latin
- Dermatitis herpetiformis
Similar endpoints
↥List of similar endpoints to
Dermatitis herpetiformis
based on the number of shared cases.
Similar with more cases:
- Other bullous disorders
- Bullous disorders
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4875 | 2511 | 2338 |
| Only index persons | 4281 | 2269 | 2012 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 45.74 | 45.97 | 45.38 |
| Only index persons | 44.15 | 44.66 | 43.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 661 | 380 | 281 |
| Unadjusted period prevalence (%) | 0.13 | 0.13 | 0.13 |
| Median age at first event (years) | 45.36 | 41.57 | 50.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 672
- Matched controls
- 6720
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K90.0
ICD-10 Finland
Coeliac disease
81.1
307.7
330
79
L13.0
ICD-10 Finland
Dermatitis herpetiformis
16384.0
307.7
552
*
J04BA02
ATC
dapsone; oral
968.1
220.1
204
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
9.5
152.6
223
333
69399
ICD-8 Finland
Dermatitis herpetiformis
+∞
138.4
128
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.8
62.2
322
1322
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.7
52.1
224
799
D07AC01
ATC
betamethasone; topical
3.2
47.6
349
1706
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.9
45.5
161
498
D07AC13
ATC
mometasone; topical
3.0
40.7
281
1301
D07AB02
ATC
hydrocortisone butyrate; topical
2.9
38.5
280
1325
E000001, ,
ATC
3.1
37.7
203
812
6940A
ICD-9 Finland
Bullous dermatoses, Dermatitis herpetiformis
+∞
31.5
30
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.7
30.5
107
324
D07AB08
ATC
desonide; topical
3.3
27.8
120
414
E000002, ,
ATC
3.3
25.9
113
392
E0000UV, ,
ATC
2.4
25.8
331
1963
D07AD01
ATC
clobetasol; topical
2.7
24.1
154
659
D07CC01
ATC
betamethasone and antibiotics; topical
2.8
21.0
122
495
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
113.6
20.7
22
*
L13.9
ICD-10 Finland
Bullous disorder, unspecified
72.0
18.8
21
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.0
18.5
55
147
L20.0
ICD-10 Finland
Besnier prurigo
3.3
18.3
73
238
RD210, ,
NOMESCO Finland
7.5
17.9
26
36
R06AE07
ATC
cetirizine; oral
2.0
17.5
316
2051
R06AE09
ATC
levocetirizine; oral
2.5
17.3
121
535
D07XB05
ATC
dexamethasone; topical
4.8
16.5
38
83
TQW80
NOMESCO Finland
Local dermatologic skincare
5.3
16.1
33
65
H02AB06
ATC
prednisolone; systemic
2.0
15.9
346
2368
D09AB01
ATC
zinc bandage without supplements; topical
6.6
15.9
26
41
E000007, ,
ATC
3.4
15.3
57
178
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
32.5
14.9
19
6
L12.0
ICD-10 Finland
Bullous pemphigoid
81.9
14.6
16
*
D07BC01
ATC
betamethasone and antiseptics; topical
2.5
13.7
99
442
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
13.2
248
1594
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.6
12.9
80
332
L30.3
ICD-10 Finland
Infective dermatitis
3.8
12.8
39
106
D02AX
ATC
Other emollients and protectives
4.4
12.6
32
76
107
Kela drug reimbursment
Pernicious anaemia
5.6
12.2
23
42
D07AA02
ATC
hydrocortisone; topical
2.2
12.2
114
569
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
5.8
12.0
22
39
R06AX13
ATC
loratadine; oral
2.2
11.8
116
590
S02
ICPC
Pruritus
3.7
11.7
38
108
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
10.1
287
2044
R06AX27
ATC
desloratadine; oral
1.8
10.0
186
1173
L29.9
ICD-10 Finland
Pruritus, unspecified
4.0
9.8
28
73
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.1
9.6
99
511
D02AE01
ATC
carbamide; topical
2.7
9.5
53
209
N05BB01
ATC
hydroxyzine; systemic
2.6
9.5
54
215
D07XC01
ATC
betamethasone; topical
2.1
9.4
95
486
69300, ,
ICD-8 Finland
+∞
9.4
9
*
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
7.3
8.8
20
28
J05AB01
ATC
aciclovir; systemic
1.8
8.5
156
974
SPAT1263
SPAT
Sampling
1.6
8.4
279
2044
K29.4
ICD-10 Finland
Chronic atrophic gastritis
4.3
8.2
21
50
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.9
8.1
24
64
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.9
8.1
24
64
E000006, ,
ATC
2.4
8.1
55
238
R06AX22
ATC
ebastine; oral
1.9
8.1
114
655
J01AA07
ATC
tetracycline; systemic
1.9
8.1
103
573
XQ800
NOMESCO Finland
Prick test
2.4
7.7
54
237
E000003, ,
ATC
2.8
7.7
38
140
D07CB01
ATC
triamcinolone and antibiotics; topical
4.4
7.7
19
44
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.7
7.6
157
1011
XQ848
NOMESCO Finland
Dermatological photography
3.4
7.6
27
82
R03DC03
ATC
montelukast; oral
1.9
7.6
112
654
R06AX12
ATC
terfenadine; oral
2.9
7.5
35
125
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
7.4
256
1876
B81
ICPC
Anaemia vit B12/folate deficiency
3.0
7.4
32
110
L28.1
ICD-10 Finland
Prurigo nodularis
8.5
7.3
15
18
D11AH01
ATC
tacrolimus; topical
8.5
7.3
15
18
L13.1
ICD-10 Finland
Subcorneal pustular dermatitis
+∞
7.3
7
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.3
152
982
UJD02
NOMESCO Finland
Gastroscopy
2.6
7.0
39
154
A10AA01, ,
ATC
3.3
6.9
26
82
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
6.8
132
833
SPAT1312
SPAT
General health counselling
1.6
6.8
202
1425
D11AX14
ATC
[U] tacrolimus
12.4
6.6
11
9
L30.0
ICD-10 Finland
Nummular dermatitis
3.0
6.5
29
101
B03BA03
ATC
hydroxocobalamin; parenteral
2.4
6.5
43
184
5790A
ICD-9 Finland
Intestinal malabsorption, Coeliac disease
14.5
6.4
10
7
J01DA01
ATC
[U] cefalexin
1.5
6.3
396
3270
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.9
6.2
29
104
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.2
6.1
23
73
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.2
6.0
48
224
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
274
1216
3.12
43.33
2.1
1.3
8.32
1.63
u/ml
3.86
111
318
203
1076
2.27
19.54
1.9
1.5
2.58
2.43
g/l
0.59
122
658
336
2386
1.82
12.82
3.1
2.7
140.39
127.15
ug/l
0.30
316
2213
185
1135
1.87
11.02
1.7
1.7
446.28
12988819.26
pmol/l
0.78
151
947
309
2221
1.72
10.66
2.4
2.3
80.54
77.14
nmol/l
1.19
284
1979
165
1007
1.85
9.86
1.9
1.7
1213.93
1197.00
nmol/l
0.07
128
763
209
1381
1.75
9.52
2.2
2.1
2.65
3.13
mg/l
2.58
175
1190
355
2719
1.65
9.14
7.0
6.6
1.21
1.21
mmol/l
0.33
294
2304
41
149
2.87
8.54
1.4
1.1
54.01
5.99
u/ml
—
10
19
397
3169
1.62
8.32
8.4
9.1
3.94
4.08
e9/l
0.67
351
2803
324
2476
1.60
8.05
6.6
5.7
1.21
1.21
mmol/l
0.75
296
2243
497
4216
1.69
7.99
7.5
7.5
75.84
77.81
u/l
0.63
465
3954
307
2322
1.59
7.93
4.8
4.7
36.05
35.70
g/l
0.55
285
2176
337
2623
1.57
7.58
6.7
6.1
27.81
27.92
%
0.07
319
2469
135
834
1.77
7.58
2.3
2.4
14.32
12.91
umol/l
1.32
126
775
494
4211
1.65
7.50
4.4
3.8
14.82
14.74
pmol/l
0.28
463
3814
294
2247
1.55
6.99
2.1
1.9
94.32
94.66
pmol/l
0.04
156
1151
480
4098
1.60
6.88
4.6
4.1
11.59
12.17
mm/h
0.42
447
3773
329
2588
1.53
6.80
6.5
5.9
56.36
57.15
%
0.61
313
2437
16
28
5.83
6.17
1.1
1.1
—
—
—
0
0
114
710
1.73
6.15
2.4
2.5
24.31
22.68
%
0.53
92
615
120
761
1.70
6.07
2.3
2.4
2.35
2.34
g/l
0.02
110
709
24
79
3.11
5.97
1.6
1.0
11.18
1.45
u/ml
1.42
12
38
599
5483
1.85
5.87
16.9
14.0
21.84
23.16
mg/l
0.44
474
4310
561
5084
1.63
5.18
5.6
4.6
1.97
2.14
mu/l
0.29
526
4645
74
430
1.81
5.05
3.9
2.8
67.77
66.50
g/l
0.72
68
394
132
904
1.57
4.86
1.2
1.3
2.21
11.11
u/ml
3.43
54
346
178
1306
1.49
4.77
1.6
1.5
20.34
20.96
nmol/l
0.24
156
1113
313
2563
1.41
4.64
15.5
13.3
1.28
1.23
inr
0.46
97
746
133
931
1.53
4.43
1.3
1.3
23.14
35.42
iu/ml
1.63
42
299
12
25
4.87
4.20
1.2
1.0
—
—
—
0
0
414
3603
1.39
4.06
5.2
4.4
1752.29
1573.92
e6/l
—
7
64
207
1607
1.42
4.04
3.3
3.2
1113.82
287.85
mg/l
0.75
128
1032
194
1489
1.43
4.03
4.9
4.0
0.00
0.01
estimate
0.69
67
495
102
689
1.57
3.97
5.8
5.9
1.02
1.04
mmol/l
0.31
97
641
91
600
1.60
3.92
3.0
4.1
247.79
255.88
u/l
0.16
86
568
229
1827
1.38
3.76
2.6
3.5
2.34
2.35
mmol/l
0.86
210
1623
603
5657
1.64
3.76
19.5
16.1
139.51
139.68
mmol/l
0.91
587
5505
374
3227
1.36
3.73
5.7
4.6
6.76
6.68
mmol/l
0.29
352
3022
218
1728
1.39
3.72
3.0
3.1
7.67
7.55
mmol/l
0.13
185
1464
409
3588
1.36
3.61
3.5
3.1
48.48
48.46
u/l
0.00
378
3357
34
172
2.03
3.55
2.3
1.5
0.21
0.24
g/l
1.02
34
164
603
5671
1.62
3.55
19.8
16.2
3.97
3.97
mmol/l
0.13
588
5516
339
2903
1.34
3.45
5.4
6.1
12.76
11.12
umol/l
1.12
308
2752
35
182
1.97
3.40
2.1
1.5
1.15
1.18
g/l
0.21
35
173
216
1733
1.36
3.36
2.8
2.4
77.80
59.96
u/l
0.50
199
1607
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
31
158
2.01
3.19
3.0
3.0
0.46
0.37
u/ml
0.42
20
89
177
1386
1.38
3.19
2.7
2.7
355.03
6331.98
umol/l
5.14
154
1221
221
1793
1.35
3.17
3.4
3.2
32.96
31.67
u/l
0.21
206
1708
43
246
1.80
3.15
1.6
2.0
1.26
1.49
g/l
1.01
34
217
29
148
2.00
2.99
1.4
1.2
2.41
12.63
u/ml
—
10
27
67
441
1.58
2.94
4.3
3.8
1.24
1.23
mmol/l
1.11
59
378
11
32
3.48
2.91
2.7
2.1
—
—
—
0
0
28
145
1.97
2.79
1.4
1.2
8.57
2.85
u/ml
—
9
19
252
2118
1.30
2.75
4.8
3.6
48.94
56.36
ng/l
0.14
171
1486
148
1153
1.36
2.72
3.3
2.5
5.55
5.70
e6/l
0.04
134
1051
182
1466
1.33
2.68
1.7
1.7
1.27
1.38
mmol/l
0.96
158
1230
114
855
1.40
2.63
1.8
1.4
—
—
—
0
0
135
1042
1.37
2.63
4.3
3.8
283.90
272.17
ng/l
0.03
94
817
633
6087
1.69
2.62
26.0
20.7
47.53
40.10
%
0.47
579
5691
86
613
1.46
2.62
2.3
2.7
12.49
8.34
umol/l
1.00
73
528
22
107
2.09
2.60
3.7
2.7
14.70
16.34
%
—
10
55
633
6090
1.68
2.58
26.0
20.7
4.41
4.48
e12/l
3.35
608
5932
316
2753
1.28
2.56
4.4
3.7
0.00
0.01
estimate
0.80
69
492
65
440
1.53
2.54
6.5
7.7
10.26
9.87
mmol/l
0.15
58
419
633
6093
1.67
2.53
26.1
20.8
133.37
135.09
g/l
2.44
621
6005
10
31
3.26
2.52
2.0
1.5
—
—
—
0
0
10
31
3.26
2.52
2.0
1.5
—
—
—
0
0
514
4771
1.33
2.51
20.2
16.8
14.79
14.96
%
0.29
503
4701
79
560
1.47
2.48
4.6
3.4
—
—
—
0
0
632
6085
1.65
2.47
26.0
20.7
244.68
248.97
e9/l
0.91
609
5940
31
174
1.82
2.46
2.8
2.1
—
—
—
0
0
183
1495
1.31
2.42
3.5
3.1
0.80
0.40
e6/l
0.36
143
1135
310
2708
1.27
2.42
4.5
3.7
0.00
0.00
estimate
0.50
70
544
205
1702
1.29
2.40
3.8
3.8
9.14
9.37
mg/mmol
0.03
124
1061
67
468
1.48
2.28
2.5
2.5
6.19
6.86
ug/l
0.17
58
422
197
1643
1.28
2.20
2.4
2.1
158.54
287.76
u/l
1.37
186
1546
609
5836
1.46
2.20
12.3
10.4
28.08
26.20
u/l
0.77
589
5630
309
2719
1.25
2.20
5.7
4.9
0.00
0.00
estimate
-0.00
68
514
15
69
2.20
2.06
1.4
2.3
17.27
5.11
umol/l
—
10
49
120
945
1.33
2.05
1.4
1.5
—
—
—
0
0
245
2117
1.25
2.01
4.9
3.8
—
—
—
0
0
89
673
1.37
1.98
9.3
7.0
—
—
—
0
0
5
11
4.57
1.94
1.0
1.1
—
—
—
0
0
229
1971
1.25
1.93
4.0
3.2
—
—
—
0
0
71
520
1.41
1.91
2.5
2.2
0.21
0.21
g/l
0.38
66
483
27
159
1.73
1.88
1.5
1.3
—
—
—
0
0
11
46
2.41
1.86
4.4
2.8
—
—
—
0
0
150
1236
1.27
1.83
5.0
4.0
1.02
1.02
kg/l
0.07
20
165
58
413
1.44
1.82
3.8
3.9
119.77
83.77
ng/l
0.86
51
369
81
613
1.37
1.80
8.7
7.5
1.75
1.27
mmol/l
0.74
65
494
21
116
1.84
1.80
1.5
1.4
47.63
11.89
e6/l
0.38
16
91
6
18
3.35
1.75
1.0
1.8
30.33
29.61
umol/l
—
6
18
53
379
1.43
1.65
1.8
1.7
—
—
—
0
0
59
432
1.40
1.61
5.3
2.9
134.87
177.39
ng/l
0.53
54
398
18
99
1.84
1.58
1.2
1.3
205.54
260.32
u/ml
0.42
12
57
567
5430
1.28
1.56
4.8
4.4
4.52
4.66
mmol/l
2.83
527
5055
10
44
2.29
1.56
1.0
1.0
—
—
—
0
0
190
1645
1.22
1.47
3.7
3.2
30.03
94.45
e6/l
0.96
149
1282
7
28
2.52
1.45
1.6
1.9
—
—
—
0
0
368
3392
1.19
1.42
3.1
3.0
—
—
—
0
0
79
621
1.31
1.40
2.3
1.8
—
—
—
0
0
7
29
2.43
1.39
1.6
1.9
—
—
—
0
0
108
885
1.26
1.39
2.1
1.8
—
—
—
0
0
18
104
1.75
1.38
1.2
1.3
—
—
—
0
0
26
168
1.57
1.33
1.8
1.3
—
—
—
0
0
12
61
1.98
1.33
1.6
1.1
—
—
—
0
0
17
98
1.75
1.32
1.5
1.6
—
—
—
0
0
46
336
1.40
1.31
1.3
1.3
—
52.99
—
0
25
6
24
2.51
1.30
1.0
1.0
—
—
—
0
0
24
153
1.59
1.30
1.2
1.4
210.14
247.93
miu/ml
0.31
14
77
13
69
1.90
1.29
1.1
1.3
—
—
—
0
0
558
5363
1.24
1.29
5.0
4.5
5.94
5.93
mmol/l
0.06
513
4903
5
18
2.79
1.28
1.2
1.3
—
—
—
0
0
544
5216
1.23
1.28
4.3
4.0
1.17
1.29
mmol/l
4.87
503
4798
26
171
1.54
1.25
1.3
1.4
—
—
—
0
0
8
36
2.24
1.24
1.3
1.0
—
—
—
0
0
77
614
1.29
1.24
2.3
1.8
—
—
—
0
0
574
5540
1.25
1.23
5.3
4.9
2.67
2.75
mmol/l
1.38
531
5126
10
49
2.06
1.22
1.0
1.1
—
—
—
0
0
8
37
2.18
1.21
1.1
1.7
—
—
—
0
0
43
318
1.38
1.16
3.3
3.3
4.44
4.60
pmol/l
0.65
36
281
15
87
1.74
1.16
1.7
1.4
111.20
109.92
u/ml
—
5
13
15
87
1.74
1.16
1.1
1.1
—
—
—
0
0
22
142
1.57
1.15
2.1
1.6
—
—
—
0
0
5
20
2.51
1.15
1.6
1.0
1486.80
1377.90
miu/ml
—
5
20
559
5395
1.21
1.11
4.8
4.4
1.48
1.48
mmol/l
0.07
518
4993
53
678
0.76
1.10
5.0
4.4
33.51
32.24
%
0.46
39
472
14
81
1.74
1.09
1.3
1.1
—
—
—
0
0
14
81
1.74
1.09
1.0
1.1
0.64
2.18
u/ml
—
8
48
12
67
1.81
1.05
3.4
1.6
33.17
32.96
pg
0.06
12
67
15
90
1.68
1.04
1.1
1.2
2.17
4.13
u/ml
—
6
30
25
171
1.48
1.03
1.2
1.1
—
—
—
0
0
25
171
1.48
1.03
1.2
1.1
—
—
—
0
0
7
35
2.01
1.00
1.6
1.8
—
—
—
0
0
281
2587
1.15
1.00
2.4
2.6
—
—
—
0
0
41
310
1.34
0.99
1.5
1.5
—
—
—
0
0
28
199
1.42
0.97
3.4
2.1
—
—
—
0
0
120
1038
1.19
0.95
2.7
3.0
2.44
2.45
mmol/l
0.56
107
916
106
907
1.20
0.94
2.7
2.7
0.94
0.98
e6/l
0.06
63
513
6
29
2.08
0.89
1.2
1.4
—
—
—
0
0
6
30
2.01
0.87
2.0
1.4
—
—
—
0
0
6
30
2.01
0.87
2.0
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
31
1.94
0.84
1.2
1.2
—
—
—
0
0
6
31
1.94
0.84
1.0
1.3
—
—
—
0
0
151
1347
1.16
0.83
3.8
3.7
90.68
91.41
%
0.15
145
1316
38
294
1.31
0.82
1.2
1.2
—
—
—
0
0
20
139
1.45
0.80
1.4
1.7
—
—
—
0
0
10
58
1.74
0.80
3.7
2.2
13.72
13.27
%
—
10
58
22
156
1.42
0.79
2.5
2.2
5449.53
3064.15
u/l
—
10
63
6
33
1.83
0.79
1.3
1.2
—
—
—
0
0
25
182
1.39
0.79
3.0
1.8
—
—
—
0
0
6
34
1.77
0.76
4.2
1.9
0.35
0.16
e9/l
—
6
28
535
5190
1.15
0.76
15.0
12.8
81.45
81.05
ml/min/173m2
0.16
425
4274
9
53
1.71
0.75
1.2
1.3
—
—
—
0
0
77
655
1.20
0.75
1.8
1.7
1.75
1.50
%
1.04
59
576
5
24
2.09
0.74
1.4
3.3
541.80
700.88
u/ml
—
5
24
19
133
1.44
0.74
1.6
1.4
—
—
—
0
0
47
381
1.25
0.72
1.1
1.2
93.10
141.92
iu/ml
0.43
22
152
10
60
1.68
0.72
2.2
1.4
11.80
17.54
ug/l
—
10
60
12
76
1.59
0.72
1.5
1.6
—
—
—
0
0
54
446
1.23
0.71
2.6
2.8
57.15
65.82
ml/min/173m2
1.27
27
180
9
59
1.53
0.68
1.1
1.1
—
—
—
0
0
17
119
1.44
0.67
2.1
4.3
28.92
27.60
mg/l
0.06
12
77
14
94
1.50
0.67
1.5
1.6
—
—
—
0
0
59
497
1.21
0.65
2.3
2.3
33.60
32.11
u/l
0.13
52
417
14
95
1.48
0.64
1.1
1.2
3.71
8.35
u/ml
—
7
43
172
1581
1.12
0.60
3.3
3.1
1174.76
1176.30
ng/l
0.00
154
1353
24
183
1.32
0.60
2.5
3.0
—
—
—
0
0
8
52
1.54
0.59
1.0
1.3
—
—
—
0
0
0
22
0.00
0.59
0.0
2.0
—
44.91
—
0
16
18
132
1.37
0.57
1.7
1.7
4.76
5.67
iu/l
—
7
39
23
176
1.32
0.57
1.5
1.6
—
—
—
0
0
6
36
1.67
0.57
4.2
1.8
260.67
462.25
e6/l
—
6
28
15
107
1.41
0.55
1.5
4.0
27.92
331.81
u/ml
0.76
15
102
523
5099
1.12
0.55
6.1
5.7
39.70
39.85
mmol/mol
0.12
483
4739
9
60
1.51
0.54
1.1
1.1
—
—
—
0
0
9
63
1.43
0.52
2.0
2.3
—
—
—
0
0
6
40
1.50
0.51
1.0
1.2
—
—
—
0
0
18
135
1.34
0.51
1.3
1.3
—
—
—
0
0
6
41
1.47
0.50
1.8
1.8
—
—
—
0
0
135
1245
1.11
0.46
1.9
1.8
0.86
1.16
mg/l
1.28
99
964
39
329
1.20
0.46
3.4
4.0
1.01
1.68
mmol/l
0.56
28
251
18
138
1.31
0.46
1.6
1.4
—
—
—
0
0
11
77
1.44
0.45
1.5
1.6
—
—
—
0
0
18
139
1.30
0.44
1.1
1.1
—
—
—
0
0
185
1739
1.09
0.42
4.5
4.8
1.78
2.50
ug/l
1.76
164
1557
12
87
1.39
0.42
1.7
1.6
—
—
—
0
0
21
167
1.27
0.42
1.7
1.4
336.70
301.90
ug/g
—
10
101
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
5
34
1.47
0.40
17.0
17.5
1404.00
1591.62
nmol/l
—
5
34
12
88
1.37
0.40
1.4
1.7
—
—
—
0
0
12
88
1.37
0.40
1.7
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
3.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.2
—
—
—
0
0
150
1403
1.09
0.39
4.5
4.1
21.98
21.48
%
0.15
62
666
29
243
1.20
0.38
1.9
1.7
—
—
—
0
0
23
279
0.82
0.38
1.0
1.0
—
—
—
0
0
5
37
1.35
0.37
1.0
1.3
—
—
—
0
0
5
76
0.66
0.36
1.0
1.0
—
—
—
0
0
25
208
1.21
0.35
1.4
1.5
—
—
—
0
0
93
855
1.10
0.35
1.7
2.1
29.76
29.57
s
0.12
87
830
9
124
0.72
0.35
1.1
1.7
—
—
—
0
0
42
473
0.88
0.31
1.8
1.8
—
—
—
0
0
18
147
1.23
0.31
2.3
2.3
63.89
86.45
ug/min
—
9
84
13
102
1.28
0.30
2.0
2.8
0.78
0.90
nmol/l
—
8
73
17
206
0.82
0.29
1.2
1.7
—
—
—
0
0
9
74
1.22
0.25
1.1
1.1
—
—
—
0
0
15
124
1.21
0.24
1.6
1.4
—
—
—
0
0
5
39
1.28
0.23
1.2
1.2
—
—
—
0
0
19
220
0.86
0.21
1.6
2.0
4.55
3.03
mg/l
0.20
13
166
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
6
51
1.18
0.19
1.2
1.2
—
—
—
0
0
6
53
1.13
0.18
1.0
1.5
—
—
—
0
0
20
227
0.88
0.18
3.0
3.1
843.40
1804.19
u/ml
0.38
20
190
97
1018
0.94
0.18
3.1
2.9
0.62
0.77
ug/l
0.93
68
662
10
82
1.22
0.17
1.5
1.5
—
—
—
0
0
61
574
1.07
0.16
3.6
4.2
2.76
32.26
ug/l
1.38
54
487
33
302
1.10
0.16
2.0
1.9
—
—
—
0
0
8
70
1.14
0.16
1.8
2.5
—
23.24
—
0
22
8
73
1.10
0.15
1.6
1.6
—
—
—
0
0
10
83
1.21
0.15
1.5
1.5
—
—
—
0
0
10
83
1.21
0.15
1.5
1.5
—
—
—
0
0
9
78
1.16
0.15
1.7
1.5
—
—
—
0
0
12
102
1.18
0.15
2.2
1.9
206.75
217.85
pmol/l
0.17
12
96
16
140
1.15
0.15
1.4
1.4
—
—
—
0
0
9
81
1.11
0.15
1.6
1.5
—
—
—
0
0
9
81
1.11
0.15
1.6
1.5
—
—
—
0
0
9
82
1.10
0.15
1.6
1.5
—
—
—
0
0
10
84
1.19
0.14
1.0
1.1
—
14.09
—
0
7
20
222
0.90
0.13
1.4
1.8
—
—
—
0
0
13
113
1.15
0.13
1.2
1.8
5.65
4.89
mmol/24h
0.56
13
98
132
1290
1.03
0.09
2.2
2.4
—
—
—
0
0
6
56
1.07
0.08
1.8
1.7
—
—
—
0
0
10
88
1.14
0.08
1.3
1.3
—
—
—
0
0
8
75
1.07
0.07
1.0
1.1
—
—
—
0
0
13
143
0.91
0.07
1.5
1.3
—
—
—
0
0
25
265
0.94
0.07
3.8
3.4
25.42
24.92
mmol/l
0.37
25
259
8
90
0.89
0.07
1.9
1.5
—
—
—
0
0
8
90
0.89
0.07
1.9
1.5
—
—
—
0
0
11
121
0.91
0.06
1.3
1.5
—
—
—
0
0
20
212
0.94
0.05
4.2
4.6
24.24
24.88
mmol/l
0.51
20
203
10
109
0.92
0.04
1.2
1.4
—
—
—
0
0
10
109
0.92
0.04
1.2
1.4
—
—
—
0
0
10
109
0.92
0.04
1.2
1.4
—
—
—
0
0
10
109
0.92
0.04
1.2
1.4
—
—
—
0
0
87
856
1.02
0.03
2.8
3.0
3.34
2.61
e6/l
0.21
44
462
10
92
1.09
0.03
1.8
1.6
—
—
—
0
0
17
162
1.05
0.02
1.5
1.5
0.02
0.05
iu/ml
—
5
30
14
147
0.95
0.01
2.1
1.8
55.07
41.95
nmol/l
0.99
14
141
11
106
1.04
0.00
1.7
1.4
—
—
—
0
0
11
106
1.04
0.00
1.7
1.4
—
—
—
0
0
13
126
1.03
0.00
1.9
1.6
—
—
—
0
0
15
147
1.02
0.00
1.3
1.2
—
—
—
0
0
48
485
0.99
0.00
4.6
3.6
1.71
2.01
mmol/l
0.19
40
395
52
517
1.01
0.00
2.0
1.9
—
—
—
0
0
20
199
1.01
0.00
6.0
4.2
1.51
1.34
mmol/l
0.36
20
193
33
331
1.00
0.00
1.6
1.7
—
—
—
0
0
57
571
1.00
0.00
2.0
2.1
—
—
—
0
0
5
57
0.88
-0.00
1.6
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
0.50
—
0
6
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.2
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
82.71
—
0
7
5
52
0.96
-0.00
1.6
1.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
52.40
—
0
5
13
130
1.00
-0.00
1.9
1.6
—
—
—
0
0
9
90
1.00
-0.00
1.9
1.7
—
—
—
0
0
6
60
1.00
-0.00
1.7
1.4
—
—
—
0
0
6
60
1.00
-0.00
1.7
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
5
52
0.96
-0.00
1.6
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.2
—
—
—
0
0
5
52
0.96
-0.00
1.6
1.5
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_DERMATHERP and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DERMATHERP | 0.983 [0.85, 1.14] | 0.828 |
| Birth year | 0.994 [0.99, 1.0] | 0.152 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1738 females with L12_DERMATHERP died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_DERMATHERP | 0.935 [0.82, 1.07] | 0.33 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 281 out of 1496 males with L12_DERMATHERP died.
Mortality risk
Mortality risk for people of age
years, who have L12_DERMATHERP.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.172% |
| 5 | 0.593% | 1.034% |
| 10 | 1.418% | 2.787% |
| 15 | 2.79% | 5.294% |
| 20 | 4.949% | 8.632% |
Relationships between endpoints
↥Index endpoint: L12_DERMATHERP – Dermatitis herpetiformis
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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