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Dermatitis herpetiformis

DOID EFO Endpoint Browser PheWeb

L12_DERMATHERP

dermatitis herpetiformis: Dermatitis herpetiformis (DH) is a chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. DH may also appear as a consequence of gluten intolerance.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L13.0
  • Hospital discharge: ICD-9 — 6940A|6942
  • Hospital discharge: ICD-8 — 693
  • Cause of death: ICD-10 — L13.0
  • Cause of death: ICD-9 — 6940A|6942
  • Cause of death: ICD-8 — 693

2 out of 7 registries used, show all original rules.

661

4. Check minimum number of events

None

661

5. Include endpoints

None

661

6. Filter based on genotype QC (FinnGen only)

661

Control definitions (FinnGen only)

Control exclude
L12_BULLOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L13
Name in latin
Dermatitis herpetiformis

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4875 2511 2338
Only index persons 4281 2269 2012
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 45.74 45.97 45.38
Only index persons 44.15 44.66 43.57

-FinnGen-

Key figures

All Female Male
Number of individuals 661 378 283
Unadjusted period prevalence (%) 0.13 0.13 0.12
Median age at first event (years) 45.33 41.57 50.36

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
601
Matched controls
6010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L13.0
ICD-10 Finland
Dermatitis herpetiformis
16384.0
323.0
492
*
K90.0
ICD-10 Finland
Coeliac disease
86.6
264.3
288
63
J04BA02
ATC
dapsone; oral
368.5
188.6
181
7
69399
ICD-8 Finland
Dermatitis herpetiformis
+∞
123.2
114
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.1
75.7
191
325
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.7
46.8
284
1165
D07AC01
ATC
betamethasone; topical
3.4
42.7
306
1404
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.9
38.2
186
613
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.1
33.3
146
432
D07AC13
ATC
mometasone; topical
3.0
31.6
245
1119
E000001
ATC
NA
3.3
30.1
189
741
D07AB02
ATC
hydrocortisone butyrate; topical
2.9
29.1
230
1050
6940A
ICD-9 Finland
Bullous dermatoses, Dermatitis herpetiformis
+∞
28.3
27
*
D07AB08
ATC
desonide; topical
4.1
25.0
107
304
E0000UV
ATC
NA
2.4
23.1
285
1625
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
59.6
20.0
23
*
L20.0
ICD-10 Finland
Besnier prurigo
4.6
18.2
65
154
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.3
17.7
95
321
D07CC01
ATC
betamethasone and antibiotics; topical
2.9
16.4
112
445
L12.0
ICD-10 Finland
Bullous pemphigoid
+∞
15.7
15
*
E000002
ATC
NA
2.9
15.5
100
382
D07AD01
ATC
clobetasol; topical
2.6
15.2
125
553
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
14.7
218
1281
E000007
ATC
NA
4.1
13.8
54
140
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
29.1
13.0
17
6
H02AB06
ATC
prednisolone; systemic
1.9
12.6
293
2012
D07XB05
ATC
dexamethasone, combinations; topical
5.7
12.4
35
64
L13.9
ICD-10 Finland
Bullous disorder, unspecified
18.5
12.1
18
10
R06AE07
ATC
cetirizine; oral
1.8
11.6
272
1855
R06AE09
ATC
levocetirizine; oral
2.4
11.5
108
506
D07AA02
ATC
hydrocortisone; topical
2.4
10.8
99
458
RD210
NOMESCO Finland
NA
6.9
10.8
26
39
R06AX13
ATC
loratadine; oral
2.3
10.7
101
476
D07BC01
ATC
betamethasone and antiseptics; topical
2.4
10.3
92
421
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.4
9.9
48
151
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
8.9
9.8
20
23
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.5
9.5
73
309
69300
ICD-8 Finland
NA
+∞
9.4
9
*
N05BB01
ATC
hydroxyzine; systemic
3.0
8.6
49
173
S02
ICPC
Pruritus
3.9
8.2
32
85
SPAT1263
SPAT
Sampling
1.7
8.1
254
1830
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
8.0
118
671
J05AB01
ATC
aciclovir; systemic
1.9
7.8
130
766
TQW80
NOMESCO Finland
Local dermatologic skincare
4.2
7.8
28
69
J01AA07
ATC
tetracycline; systemic
2.1
7.6
95
503
E000006
ATC
NA
2.6
7.4
52
211
L13.1
ICD-10 Finland
Subcorneal pustular dermatitis
+∞
7.3
7
*
D11AX14
ATC
[U] tacrolimus; topical
20.3
7.1
10
5
D07CA01
ATC
hydrocortisone and antibiotics; topical
2.0
7.1
88
466
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
7.1
137
852
D07AC14
ATC
methylprednisolone aceponate; topical
3.3
7.1
34
108
D07XC01
ATC
betamethasone, combinations; topical
2.1
7.0
81
417
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
5.1
6.8
20
40
D11AH01
ATC
tacrolimus; topical
9.5
6.8
13
14
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
6.8
232
1692
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.8
233
1698
J01DA01
ATC
[U] cefalexin; systemic
1.6
6.7
361
2940
D09AB01
ATC
zinc bandage without supplements; topical
4.3
6.7
23
55
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.0
6.6
17
29
L30.3
ICD-10 Finland
Infective dermatitis
3.2
6.6
32
103
L29.9
ICD-10 Finland
Pruritus, unspecified
4.2
6.6
23
56
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
4.2
6.6
23
56
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.4
6.5
52
226
L28.1
ICD-10 Finland
Prurigo nodularis
7.5
6.4
14
19
D02AX
ATC
Other emollients and protectives
3.3
6.1
28
87

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
265
1187
3.06
40.93
2.1
1.3
7.6
1.7
u/ml
3.51
106
308
97
253
4.32
34.19
1.7
1.1
188.9
88.5
titre
—
14
6
70
224
3.38
18.09
1.2
1.2
—
—
—
0
0
196
1056
2.22
17.96
1.9
1.5
2.6
2.4
g/l
0.59
119
647
328
2346
1.79
12.03
3.1
2.7
141.2
128.2
ug/l
0.28
308
2178
361
2674
1.77
11.58
6.9
5.8
0.6
0.6
e9/l
0.14
317
2325
368
2746
1.77
11.46
6.8
5.8
1.8
1.9
e9/l
1.87
325
2447
89
411
2.35
11.40
1.5
1.2
—
—
—
0
0
360
2686
1.75
11.07
6.9
5.8
0.0
0.0
e9/l
0.20
316
2343
369
2780
1.74
10.89
7.1
6.0
0.2
0.2
e9/l
2.45
330
2462
127
700
2.01
10.37
1.3
1.3
671.4
537.0
titre
0.24
28
151
257
1772
1.74
10.25
6.2
5.8
—
—
—
0
0
179
1120
1.82
9.90
1.7
1.7
445.5
13155514.9
pmol/l
0.78
146
935
134
765
1.94
9.85
1.4
1.2
—
—
—
0
0
161
996
1.81
9.16
1.9
1.7
1213.8
1194.6
nmol/l
0.08
126
753
350
2692
1.64
8.79
7.1
6.6
1.2
1.2
mmol/l
0.38
290
2270
202
1365
1.69
8.33
2.2
2.1
2.7
3.1
mg/l
2.29
169
1176
391
3122
1.62
8.20
8.5
9.1
4.0
4.1
e9/l
0.58
345
2759
327
2508
1.60
8.06
6.9
6.2
9.2
8.6
%
3.14
310
2353
321
2452
1.60
8.04
6.7
5.7
1.2
1.2
mmol/l
0.80
292
2212
317
2417
1.60
7.98
6.7
6.0
0.7
0.7
%
0.41
302
2255
325
2493
1.60
7.97
6.7
5.9
3.3
2.9
%
2.08
307
2324
489
4147
1.69
7.90
7.5
7.5
75.7
77.9
u/l
0.71
457
3885
331
2574
1.57
7.50
6.7
6.0
27.9
27.9
%
0.01
313
2406
300
2292
1.57
7.27
4.8
4.8
35.9
35.7
g/l
0.36
274
2148
133
829
1.76
7.23
2.3
2.4
14.2
12.9
umol/l
1.10
123
765
38
146
2.70
7.17
1.4
1.1
54.0
6.2
u/ml
—
10
18
483
4145
1.61
6.79
4.4
3.8
14.8
14.7
pmol/l
0.17
453
3752
224
1624
1.57
6.70
4.7
3.9
7.4
7.4
ph
0.71
45
298
323
2540
1.53
6.69
6.5
5.8
56.4
57.2
%
0.62
307
2387
286
2213
1.52
6.26
2.1
2.0
93.9
94.8
pmol/l
0.11
152
1134
76
416
1.93
6.24
3.0
2.7
11.3
10.5
g/l
0.66
70
381
470
4045
1.56
6.16
4.6
4.1
11.7
12.2
mm/h
0.37
438
3729
589
5391
1.85
5.78
17.0
14.1
22.0
23.2
mg/l
0.37
465
4242
12
24
5.07
5.76
1.2
1.0
—
—
—
0
0
111
706
1.69
5.54
2.4
2.5
23.9
22.7
%
0.38
90
611
172
1222
1.55
5.46
6.0
4.8
—
—
—
0
0
117
759
1.66
5.42
2.3
2.4
2.3
2.3
g/l
0.01
108
707
132
895
1.59
5.10
1.2
1.3
2.2
11.2
u/ml
3.44
54
342
549
4985
1.60
4.85
5.6
4.6
2.0
2.1
mu/l
0.26
515
4552
73
428
1.79
4.85
3.9
2.8
67.5
66.5
g/l
0.53
67
392
12
28
4.35
4.84
1.2
1.1
—
—
—
0
0
64
362
1.85
4.77
4.0
2.3
—
—
—
0
0
133
919
1.56
4.72
1.3
1.3
23.5
36.2
iu/ml
1.64
41
291
17
53
3.27
4.64
1.3
1.2
—
—
—
0
0
408
3546
1.39
4.08
5.2
4.4
1752.3
1598.1
e6/l
—
7
63
204
1584
1.42
3.98
3.3
3.2
1136.1
292.2
mg/l
0.75
125
1011
91
605
1.58
3.80
3.5
2.6
2.1
1.8
%
1.08
85
545
30
141
2.18
3.76
1.3
1.2
255.0
88.0
titre
—
8
15
21
85
2.52
3.66
1.6
1.7
0.9
0.8
g/l
0.22
16
67
189
1467
1.40
3.65
4.9
4.0
0.0
0.0
estimate
0.69
65
486
214
1700
1.38
3.60
3.0
3.1
7.6
7.5
mmol/l
0.13
182
1432
367
3173
1.35
3.58
5.8
4.6
6.8
6.7
mmol/l
0.32
345
2970
169
1291
1.42
3.57
1.6
1.5
20.6
21.0
nmol/l
0.15
148
1100
71
451
1.64
3.57
4.8
3.8
—
—
—
0
0
34
172
2.03
3.55
2.3
1.5
0.2
0.2
g/l
0.97
34
164
592
5563
1.61
3.52
19.7
16.2
139.5
139.7
mmol/l
0.96
577
5416
35
182
1.97
3.40
2.1
1.5
1.2
1.2
g/l
0.20
35
173
592
5577
1.59
3.32
19.9
16.3
4.0
4.0
mmol/l
0.24
578
5428
49
288
1.76
3.28
1.3
1.3
—
—
—
0
0
263
2186
1.34
3.24
11.9
8.6
1.3
1.2
inr
0.67
85
631
223
1809
1.35
3.23
2.6
3.5
2.3
2.4
mmol/l
0.77
204
1594
43
246
1.80
3.15
1.6
1.9
1.3
1.5
g/l
1.00
34
217
282
2377
1.33
3.12
11.7
9.4
0.0
0.0
e9/l
0.10
233
1965
211
1705
1.35
3.11
2.9
2.4
78.5
56.6
u/l
0.64
193
1579
331
2857
1.32
3.08
5.5
6.1
12.8
11.2
umol/l
1.13
300
2707
28
142
2.01
2.94
1.4
1.2
8.6
2.9
u/ml
—
9
19
173
1369
1.36
2.90
2.7
2.7
356.7
6457.1
umol/l
5.14
148
1196
57
363
1.62
2.87
8.2
5.7
—
—
—
0
0
14
53
2.68
2.81
4.5
2.4
—
—
—
0
0
490
4502
1.34
2.77
20.7
17.3
13.7
13.7
%
0.06
476
4419
180
1447
1.34
2.70
1.7
1.7
1.3
1.4
mmol/l
1.01
156
1216
24
119
2.06
2.69
2.4
1.5
—
—
—
0
0
134
1030
1.38
2.68
4.3
3.8
283.9
274.5
ng/l
0.03
94
810
66
443
1.54
2.68
4.2
2.6
79.0
71.2
e9/l
0.80
53
340
65
435
1.55
2.67
4.4
3.8
1.2
1.2
mmol/l
1.42
57
375
248
2091
1.30
2.63
4.9
3.7
49.8
57.1
ng/l
0.13
167
1462
19
88
2.19
2.53
1.1
1.1
—
—
—
0
0
311
2710
1.28
2.52
4.4
3.7
0.0
0.0
estimate
0.80
66
485
622
5984
1.67
2.52
26.0
20.7
91.6
91.1
fl
2.15
612
5898
84
601
1.46
2.52
2.4
2.7
12.6
8.4
umol/l
0.99
72
519
622
5986
1.66
2.49
26.1
20.8
4.4
4.5
e12/l
3.35
598
5828
622
5988
1.66
2.46
26.1
20.8
6.5
6.7
e9/l
2.17
598
5828
622
5989
1.65
2.44
26.2
20.9
133.3
135.0
g/l
2.42
611
5901
60
403
1.54
2.44
3.9
4.6
0.0
0.9
%
—
8
110
144
1137
1.34
2.42
3.4
2.5
5.5
5.7
e6/l
0.05
128
1011
305
2661
1.27
2.42
4.5
3.7
0.0
0.0
estimate
0.00
66
497
64
437
1.51
2.42
6.6
7.6
10.4
9.8
mmol/l
0.24
57
416
62
421
1.52
2.40
3.8
4.6
0.1
0.1
%
—
10
127
5
8
6.29
2.37
4.4
3.1
—
—
—
0
0
621
5982
1.63
2.37
26.2
20.8
244.0
248.8
e9/l
1.09
599
5837
102
766
1.39
2.35
2.2
2.1
—
—
—
0
0
621
5985
1.62
2.32
26.0
20.7
30.5
30.3
pg
1.63
612
5897
175
1430
1.30
2.31
3.4
3.0
—
—
—
0
0
83
606
1.42
2.25
2.0
1.6
—
—
—
0
0
201
1678
1.28
2.25
4.0
4.0
9.3
9.1
mg/mmol
0.02
122
1050
18
86
2.12
2.24
1.7
1.7
—
—
—
0
0
305
2678
1.26
2.24
5.7
5.0
0.0
0.0
estimate
0.00
66
504
179
1473
1.30
2.23
3.5
3.1
0.8
0.4
e6/l
0.38
138
1111
21
107
1.99
2.22
3.8
2.7
14.7
16.3
%
—
10
55
66
464
1.47
2.18
2.5
2.5
6.2
6.9
ug/l
0.17
57
418
64
449
1.47
2.14
3.8
4.4
0.3
1.0
%
—
10
141
30
175
1.75
2.13
1.8
1.6
—
—
—
0
0
9
31
2.93
2.08
1.9
1.2
—
—
—
0
0
30
177
1.73
2.06
1.8
1.6
—
—
—
0
0
598
5738
1.44
2.06
12.3
10.4
28.0
26.1
u/l
0.75
578
5536
95
722
1.37
2.05
1.7
1.6
—
—
—
0
0
65
462
1.45
2.04
4.5
3.4
—
—
—
0
0
77
565
1.41
2.04
1.6
1.5
—
—
—
0
0
25
140
1.82
2.03
1.9
1.5
—
—
—
0
0
30
178
1.72
2.02
1.9
1.6
—
—
—
0
0
28
165
1.73
1.94
1.9
1.6
—
—
—
0
0
81
606
1.38
1.93
8.7
7.5
1.7
1.3
mmol/l
0.65
65
480
192
1623
1.26
1.90
2.5
2.2
156.3
288.7
u/l
1.39
181
1528
21
114
1.87
1.89
1.5
1.4
47.6
12.0
e6/l
0.38
16
89
12
52
2.33
1.88
1.1
1.1
—
—
—
0
0
7
22
3.20
1.88
8.7
6.1
—
—
—
0
0
419
3856
1.24
1.88
4.2
3.8
—
—
—
0
0
57
403
1.45
1.86
3.6
4.4
0.6
0.5
%
—
7
100
148
1216
1.28
1.85
5.0
4.0
1.0
1.0
kg/l
0.08
20
162
29
176
1.68
1.82
1.8
1.6
—
—
—
0
0
111
880
1.31
1.82
1.7
1.8
—
—
—
0
0
69
510
1.39
1.77
2.4
2.2
0.2
0.2
g/l
0.41
64
475
57
407
1.44
1.77
3.8
3.9
121.4
84.1
ng/l
0.88
50
363
6
18
3.35
1.75
1.0
1.8
30.3
29.6
umol/l
—
6
18
150
1244
1.27
1.74
4.2
3.7
—
—
—
0
0
8
30
2.69
1.73
1.6
1.3
—
—
—
0
0
18
96
1.90
1.72
1.6
1.4
—
—
—
0
0
21
119
1.79
1.68
1.7
1.8
—
—
—
0
0
406
3748
1.22
1.66
4.9
4.3
—
—
—
0
0
13
62
2.12
1.66
1.4
1.3
—
—
nmol/l
—
0
0
7
25
2.82
1.65
2.3
1.5
—
—
—
0
0
129
1057
1.27
1.65
3.2
2.8
526.2
557.2
mosm/kgh2o
0.89
111
911
192
1648
1.23
1.64
3.8
3.0
—
—
—
0
0
516
4887
1.25
1.63
17.6
14.9
39.3
39.8
%
0.55
328
3477
11
50
2.22
1.57
1.2
1.2
—
—
—
0
0
19
107
1.80
1.56
6.5
4.5
3.5
2.5
mmol/l
1.05
14
74
14
71
1.99
1.55
1.0
1.0
8.6
6.1
u/ml
—
7
34
60
446
1.38
1.52
1.5
1.6
—
—
—
0
0
58
429
1.39
1.51
5.3
2.9
137.3
178.1
ng/l
0.49
53
395
13
65
2.02
1.49
1.1
1.0
0.5
0.8
u/ml
—
7
28
83
651
1.31
1.49
2.0
2.3
80.5
127.1
ug/g
1.87
62
514
17
94
1.83
1.48
1.2
1.3
164.0
267.8
u/ml
1.43
11
54
216
1894
1.21
1.48
4.0
3.8
87.3
97.7
e6/l
0.13
163
1360
88
697
1.30
1.47
19.5
21.5
1.2
1.3
inr
—
8
94
40
278
1.47
1.46
12.8
9.9
—
—
—
0
0
25
156
1.63
1.45
1.3
1.3
—
—
—
0
0
557
5346
1.27
1.42
4.9
4.4
4.5
4.7
mmol/l
2.78
517
4968
46
331
1.42
1.41
1.3
1.4
—
40.5
—
0
19
15
81
1.87
1.41
1.3
1.2
—
—
—
0
0
15
81
1.87
1.41
1.1
1.0
—
—
—
0
0
13
67
1.96
1.39
1.4
2.3
18.1
5.1
umol/l
—
8
48
23
143
1.63
1.37
1.2
1.2
—
—
—
0
0
186
1621
1.21
1.35
3.7
3.2
30.6
95.6
e6/l
0.95
145
1264
18
105
1.73
1.34
1.2
1.5
—
—
—
0
0
9
42
2.16
1.34
1.1
1.5
—
—
—
0
0
11
54
2.05
1.33
1.4
1.1
—
—
—
0
0
33
469
0.69
1.29
1.5
1.3
—
—
—
0
0
5
18
2.79
1.28
1.6
1.0
1486.8
1356.7
miu/ml
—
5
18
15
84
1.80
1.28
1.7
1.3
111.2
110.0
u/ml
—
5
12
11
55
2.02
1.28
1.3
1.5
—
—
—
0
0
84
676
1.28
1.26
1.6
1.4
—
—
—
0
0
22
139
1.60
1.24
1.1
1.1
—
—
—
0
0
581
5625
1.27
1.22
18.1
13.3
—
—
—
0
0
165
1436
1.20
1.21
5.9
4.3
—
—
—
0
0
12
64
1.89
1.18
1.4
1.3
—
—
—
0
0
14
79
1.79
1.17
1.0
1.1
0.6
1.6
u/ml
—
8
32
5
20
2.51
1.15
2.6
1.9
—
—
—
0
0
534
5134
1.21
1.14
4.3
4.0
1.2
1.3
mmol/l
4.38
494
4721
23
151
1.54
1.13
1.2
1.4
224.8
244.2
miu/ml
0.14
13
76
7
30
2.35
1.12
1.0
2.0
—
—
—
0
0
477
4543
1.18
1.12
22.6
18.3
332.4
332.3
g/l
0.10
471
4516
102
854
1.23
1.11
2.3
3.3
0.8
0.8
mmol/l
0.21
97
805
564
5456
1.23
1.10
5.3
4.9
2.7
2.7
mmol/l
1.38
521
5040
28
194
1.46
1.08
2.0
1.6
—
—
—
0
0
547
5282
1.21
1.05
4.9
4.5
5.9
5.9
mmol/l
0.01
503
4832
25
171
1.48
1.03
1.2
1.1
—
—
—
0
0
17
107
1.60
1.00
5.6
3.8
—
—
—
0
0
47
363
1.32
0.99
1.9
2.7
3.3
4.0
e9/l
1.25
38
288
549
5311
1.20
0.98
4.8
4.4
1.5
1.5
mmol/l
0.06
508
4908
0
30
0.00
0.97
0.0
1.5
—
—
—
0
0
16
100
1.61
0.97
3.3
2.9
—
—
—
0
0
151
1330
1.18
0.97
3.8
3.7
90.7
91.3
%
0.13
145
1299
0
31
0.00
0.96
0.0
3.6
—
—
—
0
0
19
125
1.54
0.95
7.5
4.1
—
—
—
0
0
38
288
1.34
0.92
2.3
2.3
—
—
—
0
0
27
193
1.42
0.91
1.0
1.1
—
—
—
0
0
16
102
1.58
0.91
1.2
1.5
—
—
—
0
0
71
587
1.23
0.89
1.5
1.7
—
—
—
0
0
11
64
1.73
0.86
1.7
1.4
28.2
32.5
g/l
0.60
11
53
8
44
1.83
0.86
1.0
1.1
—
0.1
—
0
6
275
2550
1.13
0.86
4.1
4.0
—
—
—
0
0
40
310
1.31
0.84
3.5
3.2
4.4
4.6
pmol/l
0.65
34
273
8
45
1.79
0.84
3.4
1.8
0.9
1.1
e9/l
—
8
24
10
58
1.74
0.80
1.6
1.7
—
—
—
0
0
6
34
1.77
0.76
4.2
1.9
0.4
0.2
e9/l
—
6
28
6
34
1.77
0.76
1.7
1.5
—
1930.5
—
0
8
10
59
1.71
0.76
2.2
1.4
11.8
17.6
ug/l
—
10
59
11
67
1.65
0.75
3.6
1.6
32.8
33.0
pg
0.04
11
67
22
158
1.41
0.75
4.2
3.0
—
—
—
0
0
14
208
0.67
0.75
2.4
2.8
—
—
—
0
0
116
1023
1.16
0.75
2.7
3.0
2.4
2.5
mmol/l
0.44
103
903
31
237
1.32
0.74
1.3
1.6
—
6.5
—
0
6
21
151
1.40
0.72
2.5
2.2
5449.5
3023.8
u/l
—
10
61
17
118
1.45
0.70
2.1
4.3
28.9
27.7
mg/l
0.06
12
76
24
318
0.75
0.69
1.5
1.4
—
—
—
0
0
9
59
1.53
0.68
1.1
1.5
—
—
—
0
0
5
92
0.54
0.67
1.4
1.5
—
—
—
0
0
14
94
1.50
0.67
1.1
1.2
3.7
8.5
u/ml
—
7
42
13
86
1.52
0.66
1.2
1.1
—
—
—
0
0
13
86
1.52
0.66
1.2
1.1
—
—
—
0
0
28
215
1.32
0.66
6.0
4.6
—
—
—
0
0
15
103
1.47
0.65
1.5
4.1
27.9
344.9
u/ml
0.76
15
98
43
352
1.24
0.63
3.2
4.0
5.0
5.1
kpa
0.42
38
331
171
1569
1.12
0.62
3.3
3.1
1182.2
1184.4
ng/l
0.00
153
1343
31
244
1.28
0.62
3.5
2.4
0.9
0.7
%
1.34
31
237
8
49
1.64
0.62
1.8
1.3
—
—
—
0
0
10
63
1.60
0.62
1.3
1.2
—
—
—
0
0
27
210
1.30
0.59
1.6
2.2
25.3
21.6
s
0.32
22
192
135
1226
1.13
0.59
1.9
1.8
0.9
1.2
mg/l
1.31
99
950
8
53
1.52
0.58
1.9
1.4
—
—
—
0
0
8
53
1.52
0.58
1.5
1.2
5.4
6.7
mmol/l
—
8
48
45
374
1.22
0.58
1.2
1.2
95.3
144.6
iu/ml
0.41
21
148
6
36
1.67
0.57
4.2
1.8
260.7
462.3
e6/l
—
6
28
5
89
0.56
0.56
1.4
1.4
—
—
—
0
0
5
89
0.56
0.56
1.4
1.4
—
—
—
0
0
515
5020
1.12
0.55
6.0
5.7
39.7
39.8
mmol/mol
0.14
475
4670
46
386
1.21
0.55
1.4
1.4
—
—
—
0
0
185
1718
1.11
0.54
4.5
4.8
1.8
2.5
ug/l
1.79
164
1538
9
60
1.51
0.54
1.3
1.1
—
—
—
0
0
9
62
1.46
0.53
2.0
2.3
—
—
—
0
0
11
76
1.45
0.48
2.5
3.1
—
—
—
0
0
21
164
1.29
0.47
5.9
4.0
3.8
3.9
mmol/l
0.25
21
152
7
48
1.46
0.47
1.3
2.6
—
—
—
0
0
7
49
1.43
0.46
1.3
1.3
—
—
—
0
0
27
219
1.24
0.46
1.1
1.1
—
—
—
0
0
41
348
1.19
0.45
3.3
4.0
7.4
7.4
ph
—
7
43
14
103
1.37
0.45
3.0
2.6
—
—
—
0
0
7
50
1.40
0.45
1.6
1.6
—
—
—
0
0
5
31
1.62
0.43
1.2
1.1
—
—
—
0
0
146
1358
1.10
0.42
5.8
6.7
—
—
—
0
0
41
351
1.18
0.42
1.3
1.4
—
—
—
0
0
157
1468
1.09
0.41
4.4
3.3
—
—
—
0
0
93
847
1.11
0.41
1.7
2.1
29.8
29.6
s
0.10
87
822
0
17
0.00
0.40
0.0
2.6
—
—
—
0
0
5
34
1.47
0.40
6.2
1.4
—
—
—
0
0
7
103
0.68
0.39
1.3
1.3
—
—
—
0
0
10
72
1.39
0.37
1.2
1.2
—
—
—
0
0
9
70
1.29
0.36
1.1
1.2
—
—
—
0
0
21
255
0.82
0.35
2.2
1.7
—
—
—
0
0
18
144
1.26
0.35
2.3
2.4
63.9
87.4
ug/min
—
9
83
226
2161
1.07
0.34
2.0
2.1
—
—
—
0
0
6
45
1.34
0.34
1.2
1.2
—
—
—
0
0
53
474
1.13
0.33
1.4
1.4
—
—
—
0
0
20
164
1.23
0.33
1.7
1.4
336.7
303.7
ug/g
—
10
100
10
74
1.36
0.32
1.8
2.4
—
—
—
0
0
140
1484
0.93
0.31
1.4
1.4
—
—
—
0
0
68
621
1.11
0.30
1.3
1.3
—
—
—
0
0
7
54
1.30
0.30
2.6
2.5
—
—
—
0
0
13
102
1.28
0.30
2.0
2.8
0.8
0.9
nmol/l
—
8
73
32
366
0.87
0.29
2.7
2.6
—
—
—
0
0
167
1589
1.07
0.29
4.7
3.8
—
—
—
0
0
16
131
1.23
0.27
1.7
1.7
4.8
5.8
iu/l
—
7
38
22
187
1.18
0.27
5.1
3.2
0.3
0.3
g/l
0.03
12
72
12
149
0.80
0.26
5.5
4.5
—
—
—
0
0
57
523
1.10
0.24
3.9
3.9
—
—
—
0
0
5
39
1.28
0.23
4.0
1.7
—
685.9
—
0
14
5
41
1.22
0.22
2.0
1.1
—
—
—
0
0
61
566
1.09
0.21
3.6
4.2
2.8
32.5
ug/l
1.37
54
481
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
6688.5
—
0
11
0
10
0.00
0.21
0.0
5.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
11
89
1.24
0.21
2.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
3.1
—
50.0
—
0
8
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
14
117
1.20
0.20
1.1
1.3
—
—
—
0
0
7
62
1.13
0.17
1.6
1.2
—
—
—
0
0
10
82
1.22
0.17
1.0
1.1
—
14.1
—
0
7
12
101
1.19
0.16
2.2
1.9
206.8
218.0
pmol/l
0.17
12
95
24
266
0.90
0.16
4.3
3.5
—
—
—
0
0
13
111
1.17
0.16
4.8
2.9
—
—
—
0
0
71
673
1.06
0.15
1.2
1.3
—
—
—
0
0
20
224
0.89
0.15
2.9
3.2
843.4
1831.9
u/ml
0.39
20
187
9
81
1.11
0.15
1.0
1.5
—
—
—
0
0
10
84
1.19
0.14
3.0
1.6
73.1
61.9
%
—
10
84
25
228
1.10
0.13
1.9
1.7
—
—
—
0
0
19
211
0.90
0.13
4.4
4.6
24.2
24.9
mmol/l
0.52
19
202
9
110
0.82
0.13
1.2
1.2
—
—
—
0
0
97
1004
0.96
0.11
3.1
2.9
0.6
0.8
ug/l
0.96
68
654
49
516
0.95
0.11
1.6
1.4
—
—
—
0
0
131
1278
1.03
0.09
2.2
2.4
—
—
—
0
0
24
258
0.93
0.09
3.8
4.1
—
—
—
0
0
5
48
1.04
0.09
1.0
1.5
—
—
—
0
0
11
97
1.14
0.09
1.6
1.7
—
—
—
0
0
48
497
0.96
0.06
5.1
3.7
—
—
—
0
0
10
110
0.91
0.05
1.1
1.6
—
—
—
0
0
194
1919
1.02
0.05
3.3
2.9
—
—
—
0
0
19
179
1.06
0.05
12.9
9.7
—
—
—
0
0
25
262
0.95
0.05
3.8
3.4
25.4
24.9
mmol/l
0.36
25
256
33
340
0.97
0.03
1.1
1.2
—
—
—
0
0
10
93
1.08
0.02
1.3
1.5
—
—
—
0
0
45
458
0.98
0.01
1.4
1.4
—
—
—
0
0
11
116
0.95
0.00
2.1
2.0
—
—
—
0
0
10
95
1.05
0.00
1.1
1.2
—
—
—
0
0
14
144
0.97
0.00
2.1
1.8
55.1
42.1
nmol/l
0.97
14
138
20
196
1.02
0.00
6.0
4.2
1.5
1.3
mmol/l
0.34
20
190
13
133
0.98
0.00
1.5
1.3
—
—
—
0
0
42
415
1.01
0.00
8.5
7.6
—
—
—
0
0
48
479
1.00
0.00
4.6
3.6
1.6
2.0
mmol/l
0.22
39
379
170
1701
1.00
0.00
2.3
2.4
—
—
—
0
0
6
60
1.00
0.00
1.7
1.4
—
—
—
0
0
6
60
1.00
0.00
1.7
1.4
—
—
—
0
0
6
60
1.00
0.00
1.7
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
6
60
1.00
0.00
1.7
1.4
—
—
—
0
0
7
73
0.96
0.00
2.3
2.7
—
—
—
0
0
5
50
1.00
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
1.7
1.1
—
—
—
0
0
5
58
0.86
0.00
1.2
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
18.6
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint L12_DERMATHERP and mortality.

Females

Parameter HR [95% CI] p-value
L12_DERMATHERP 0.983 [0.85, 1.14] 0.828
Birth year 0.994 [0.99, 1.0] 0.152

During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 1738 females with L12_DERMATHERP died.

Males

Parameter HR [95% CI] p-value
L12_DERMATHERP 0.935 [0.82, 1.07] 0.33
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 281 out of 1496 males with L12_DERMATHERP died.

Mortality risk

Mortality risk for people of age

years, who have L12_DERMATHERP.

N-year risk Females Males
1 0.093% 0.172%
5 0.593% 1.034%
10 1.418% 2.787%
15 2.79% 5.294%
20 4.949% 8.632%

Relationships between endpoints

↥

Index endpoint: L12_DERMATHERP – Dermatitis herpetiformis

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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