Other bullous disorders

L12_BULLOTH

subcorneal pustular dermatosis: a rare, benign, chronic relapsing sterile pustular eruption typically involving the flexural sites of the trunk and proximal extremities. It most commonly affects woman aged 40 years or older.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L13
  • Cause of death: ICD-10 L13

2 out of 7 registries used, show all original rules.

904

4. Check minimum number of events

None

904

5. Include endpoints

1037

6. Filter based on genotype QC (FinnGen only)

1017

Control definitions (FinnGen only)

Control exclude
L12_BULLOUS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L10-L14
Name in latin
Aliae morbositates bullosae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7656 4036 3577
Only index persons 6569 3572 2997
Unadjusted period prevalence (%)
Whole population 0.11 0.12 0.10
Only index persons 0.12 0.13 0.11
Median age at first event (years)
Whole population 48.42 48.66 48.09
Only index persons 47.51 47.64 47.37

-FinnGen-

Key figures

All Female Male
Number of individuals 1017 599 418
Unadjusted period prevalence (%) 0.20 0.21 0.19
Median age at first event (years) 49.97 47.04 54.16

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1037
Matched controls
10370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L13.9
ICD-10 Finland
Bullous disorder, unspecified
852.5
307.7
304
5
K90.0
ICD-10 Finland
Coeliac disease
41.1
307.7
337
120
L13.0
ICD-10 Finland
Dermatitis herpetiformis
10937.4
307.7
554
*
J04BA02
ATC
dapsone; oral
412.8
232.2
225
7
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.5
202.8
321
519
69399
ICD-8 Finland
Dermatitis herpetiformis
+∞
136.5
128
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.9
90.8
367
1265
D07AC01
ATC
betamethasone; topical
3.2
73.2
533
2586
L12.0
ICD-10 Finland
Bullous pemphigoid
365.7
69.5
69
*
L13.8
ICD-10 Finland
Other specified bullous disorders
128.8
67.8
72
6
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
3.8
65.0
244
781
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
60.5
434
2037
TQW80
NOMESCO Finland
Local dermatologic skincare
8.6
60.4
80
100
D07AD01
ATC
clobetasol; topical
3.1
49.0
261
1022
D07AC13
ATC
mometasone; topical
2.7
48.7
406
2014
E000001, ,
ATC
2.8
46.0
299
1301
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
43.0
404
2097
D07AB08
ATC
desonide; topical
3.3
40.2
177
615
E0000UV, ,
ATC
2.3
39.2
523
3139
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.3
37.4
157
528
H02AB06
ATC
prednisolone; systemic
2.2
31.8
554
3603
6940A
ICD-9 Finland
Bullous dermatoses, Dermatitis herpetiformis
+∞
31.4
30
*
R06AE07
ATC
cetirizine; oral
2.0
27.7
498
3222
E000002, ,
ATC
2.8
27.4
155
613
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
25.2
397
2429
XQ848
NOMESCO Finland
Dermatological photography
4.7
24.1
57
127
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.8
23.7
127
487
D07BC01
ATC
betamethasone and antiseptics; topical
2.5
22.8
156
677
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
85.4
22.8
25
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.6
21.8
73
211
L20.0
ICD-10 Finland
Besnier prurigo
2.9
21.7
106
386
L30.3
ICD-10 Finland
Infective dermatitis
3.9
20.7
63
170
D09AB01
ATC
zinc bandage without supplements; topical
6.0
20.2
36
62
L12.9
ICD-10 Finland
Pemphigoid, unspecified
75.0
19.8
22
*
RD210, ,
NOMESCO Finland
6.0
19.7
35
60
D02AX
ATC
Other emollients and protectives
4.1
19.4
55
141
D07CC01
ATC
betamethasone and antibiotics; topical
2.3
18.7
163
784
D07XC01
ATC
betamethasone; topical
2.3
16.9
149
719
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.1
16.4
70
236
A46
ICD-10 Finland
Erysipelas
2.2
16.4
162
819
D07AA02
ATC
hydrocortisone; topical
2.1
16.3
170
876
E000007, ,
ATC
2.9
16.2
79
287
R06AE09
ATC
levocetirizine; oral
2.1
16.0
164
839
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.7
16.0
37
81
XQ802
NOMESCO Finland
Epicutan test
3.3
15.0
58
184
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.0
14.8
26
44
J01FF01
ATC
clindamycin; systemic
1.8
14.7
291
1857
K90.9
ICD-10 Finland
Intestinal malabsorption, unspecified
22.6
14.2
20
9
L29.9
ICD-10 Finland
Pruritus, unspecified
3.7
14.2
45
125
R06AX27
ATC
desloratadine; oral
1.8
14.1
290
1867
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
3.6
14.0
46
131
107
Kela drug reimbursment
Pernicious anaemia
5.0
13.9
30
62
L13.1
ICD-10 Finland
Subcorneal pustular dermatitis
+∞
13.6
13
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
13.5
150
790
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.4
13.3
47
141
XQ800
NOMESCO Finland
Prick test
2.5
13.1
88
376
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.1
13.0
130
658
J05AB01
ATC
aciclovir; systemic
1.8
12.9
240
1495
L04AX03
ATC
methotrexate; systemic
2.2
12.8
114
550
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.0
12.7
57
198
H02AB09
ATC
hydrocortisone; systemic
3.9
12.4
36
94
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
12.3
240
1515
R06.0
ICD-10 Finland
Dyspnoea
1.7
12.3
283
1871
J01DB01
ATC
cefalexin; oral
1.8
12.2
840
7294
D02AE01
ATC
carbamide; topical
2.5
12.2
81
344
R06AX13
ATC
loratadine; oral
1.9
12.1
162
909
A10AA01, ,
ATC
3.6
11.8
38
107
B03BA03
ATC
hydroxocobalamin; parenteral
2.6
11.7
68
271
S02
ICPC
Pruritus
3.0
11.5
50
170
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.4
11.4
78
336
A10AB01
ATC
insulin (human); parenteral
3.2
11.4
45
145
L40.0
ICD-10 Finland
Psoriasis vulgaris
2.9
11.0
51
180
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.7
11.0
238
1540
S29
ICPC
Skin symptom/complaint other
1.8
11.0
201
1242
S97
ICPC
Chronic ulcer skin
2.5
10.9
72
305
D07XB05
ATC
dexamethasone; topical
3.4
10.9
39
118
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.7
10.8
206
1287
R60.0
ICD-10 Finland
Localized oedema
2.0
10.7
131
711
L04AX01
ATC
azathioprine; systemic
2.8
10.7
52
189
L04AD01
ATC
ciclosporin; systemic
4.2
10.7
28
68
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.9
10.6
141
789
317
Kela drug reimbursment
Topical pimecrolimus and tacrolimus
4.5
10.5
25
56
J01MA02
ATC
ciprofloxacin; systemic
1.6
10.5
382
2809
A02BC02
ATC
pantoprazole; systemic
1.6
10.3
669
5579
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
10.0
130
720
H04AA01
ATC
glucagon; nasal, parenteral
3.8
9.9
30
81
E000003, ,
ATC
2.6
9.6
55
218
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
9.5
418
3186
L30.0
ICD-10 Finland
Nummular dermatitis
2.8
9.5
46
167
S99
ICPC
Skin disease other
3.6
9.4
30
84
S18
ICPC
Laceration/cut
1.5
9.4
454
3527
P01BA02
ATC
hydroxychloroquine; oral
2.1
9.4
90
447
69300, ,
ICD-8 Finland
+∞
9.4
9
*
L13
ICD-10 Finland
Other bullous disorders
21.9
9.4
13
6
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
9.3
131
744
J45.9
ICD-10 Finland
Asthma, unspecified
1.7
9.3
193
1231
J01AA07
ATC
tetracycline; systemic
1.8
9.3
153
914
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
9.3
217
1428
D05BB02
ATC
acitretin; oral
3.4
9.2
32
95
SPAT1312
SPAT
General health counselling
1.6
9.2
313
2253
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.6
9.1
30
86
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.3
9.1
33
101
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.7
9.1
47
177
A10AA02, ,
ATC
3.0
9.0
40
138
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
9.0
452
3530
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
9.0
384
2900
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
9.0
352
2610
J01DA01
ATC
[U] cefalexin
1.5
9.0
608
5045
R03DC03
ATC
montelukast; oral
1.7
9.0
165
1017
L28.1
ICD-10 Finland
Prurigo nodularis
8.0
8.9
19
24
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.7
8.9
183
1164
N05BB01
ATC
hydroxyzine; systemic
2.2
8.9
72
335
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
8.7
285
2030
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
8.7
346
2571
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.4
8.7
30
89
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
8.6
174
1101
J01CF05
ATC
flucloxacillin; systemic
2.2
8.6
69
320
R49.08
ICD-10 Finland
Other specified dysphonia
3.5
8.5
29
85
N02AX02
ATC
tramadol; systemic, rectal
1.5
8.5
420
3259
J05AB11
ATC
valaciclovir; oral
1.8
8.4
149
907
R03BA01
ATC
beclometasone; inhalant
1.8
8.4
138
823
L30.8
ICD-10 Finland
Other specified dermatitis
3.1
8.4
35
117
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
8.4
134
793
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
8.3
8
*
H3603, E103,
ICD-10 Finland
9.5
8.3
16
17
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
8.2
113
637
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.1
8.2
73
353
R06AX22
ATC
ebastine; oral
1.7
8.0
163
1031
ZY010
NOMESCO Finland
Hospital outpatient
2.3
7.9
58
258
B81
ICPC
Anaemia vit B12/folate deficiency
2.7
7.9
43
166
D06AX01
ATC
fusidic acid; topical
1.9
7.8
101
558
E000006, ,
ATC
2.1
7.8
76
380
D11AH01
ATC
tacrolimus; topical
7.0
7.8
18
26
H3600, E103,
ICD-10 Finland
6.0
7.7
20
34
J01MA12
ATC
levofloxacin; systemic
1.6
7.6
179
1175
SPAT1099
SPAT
Measurement of blood pressure with Doppler ultrasound device
2.8
7.6
37
135
N02BE01
ATC
paracetamol; systemic, rectal
1.7
7.5
890
8132
K11.70
ICD-10 Finland
Hypoptyalism
10.1
7.5
14
14
SPAT1263
SPAT
Sampling
1.5
7.5
403
3160
J01DA09
ATC
[U] cefadroxil
1.5
7.4
252
1800
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
2.7
7.4
38
143
UJF32
NOMESCO Finland
Coloscopy
1.5
7.3
251
1796
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
7.3
131
800
H02AB04
ATC
methylprednisolone; systemic
1.7
7.3
143
895
135
Kela drug reimbursment
Pemphigus
+∞
7.3
7
*
R52.9
ICD-10 Finland
Pain, unspecified
1.9
7.3
98
549
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
7.3
295
2186
L29.8
ICD-10 Finland
Other pruritus
4.3
7.2
18
42
J45.0
ICD-10 Finland
Predominantly allergic asthma
1.9
7.2
92
507
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
7.2
403
3177
UJD02
NOMESCO Finland
Gastroscopy
2.3
7.2
52
231
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
3.4
7.1
25
75
T89
ICPC
Diabetes insulin dependent
2.5
7.0
44
183
L01.0
ICD-10 Finland
Impetigo [any organism] [any site]
3.6
6.9
22
62
C03CA01
ATC
furosemide; systemic
1.5
6.9
281
2083
L17
ICPC
Foot/toe symptom/complaint
1.5
6.9
274
2021
R03AC02
ATC
salbutamol; inhalant
1.4
6.9
529
4403
M79.6
ICD-10 Finland
Pain in limb
1.4
6.9
397
3142
A10AE06
ATC
insulin degludec; parenteral
2.5
6.8
40
161
K29.4
ICD-10 Finland
Chronic atrophic gastritis
3.3
6.7
24
73
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.5
6.7
240
1731
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
2.6
6.7
38
151
R03BA02
ATC
budesonide; inhalant
1.6
6.7
173
1162
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.6
237
1707
ZX120
NOMESCO Finland
Intravenous
1.8
6.6
92
521
SPAT1301
SPAT
No procedures
1.5
6.6
299
2258
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
6.6
269
1991
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
12.3
6.6
11
9
J45
ICD-10 Finland
Asthma
1.8
6.6
98
567
A10AB05
ATC
insulin aspart; parenteral
1.9
6.5
75
399
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.4
6.5
419
3370
C07AB07
ATC
bisoprolol; oral
1.4
6.5
456
3724
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
1.8
6.5
90
510
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.4
6.4
41
173
A10AC01
ATC
insulin (human); parenteral
1.9
6.3
78
425
D11AX14
ATC
[U] tacrolimus
9.3
6.3
12
13
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.1
6.3
59
292
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
6.3
6
*
D64.9
ICD-10 Finland
Anaemia, unspecified
1.8
6.2
97
569
L73.8
ICD-10 Finland
Other specified follicular disorders
5.4
6.2
17
32
A10AE05
ATC
insulin detemir; parenteral
2.1
6.1
56
274
J46
ICD-10 Finland
Status asthmaticus
2.9
6.1
28
99
A06AD11
ATC
lactulose; oral
1.6
6.1
139
904
R07.0
ICD-10 Finland
Pain in throat
2.0
6.1
62
317
D07CB01
ATC
triamcinolone and antibiotics; topical
3.2
6.0
23
73
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
10.1
6.0
11
11
J02AC01
ATC
fluconazole; systemic
1.4
6.0
357
2822
M05BA04
ATC
alendronic acid; oral
1.8
6.0
84
477

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
96
39
27.02
137.93
1.4
1.1
33.64
78.33
titre
—
11
6
96
42
25.09
134.12
1.4
1.2
801.43
—
titre
—
7
0
395
1874
2.79
52.50
1.9
1.3
6.88
1.77
u/ml
3.61
142
506
136
347
4.36
48.92
1.3
1.2
—
—
—
0
0
130
397
3.60
36.00
1.5
1.1
176.56
147.89
titre
—
16
9
325
1646
2.42
35.23
1.8
1.5
2.46
2.42
g/l
0.15
199
1000
614
4334
2.02
26.26
8.0
5.8
1.80
1.94
e9/l
2.05
549
3853
602
4220
2.02
26.25
8.0
5.8
0.60
0.58
e9/l
0.91
534
3661
602
4228
2.01
26.02
8.0
5.8
0.04
0.04
e9/l
0.96
535
3675
617
4371
2.02
26.02
8.3
6.1
0.22
0.19
e9/l
3.30
554
3857
571
3988
1.96
24.49
8.8
6.3
—
—
—
0
0
661
4910
1.95
22.98
10.8
9.0
4.11
4.09
e9/l
0.06
592
4329
560
3970
1.89
22.08
8.3
6.2
8.92
8.56
%
1.85
533
3715
147
632
2.54
21.83
1.4
1.2
—
—
—
0
0
556
3950
1.88
21.60
8.0
5.9
3.16
2.87
%
2.22
533
3693
585
4226
1.88
21.54
8.1
6.9
1.21
1.21
mmol/l
0.72
507
3582
540
3823
1.86
20.99
8.0
5.9
0.71
0.67
%
0.90
516
3568
566
4074
1.86
20.79
8.1
6.0
27.62
28.05
%
0.40
540
3826
518
3655
1.83
20.02
3.4
2.8
141.98
126.33
ug/l
0.52
490
3373
554
4011
1.82
19.47
7.8
5.8
57.08
57.04
%
0.03
530
3767
505
3599
1.79
18.32
5.4
4.9
35.21
35.50
g/l
0.55
471
3357
486
3442
1.78
17.87
2.6
2.3
80.09
77.52
nmol/l
1.13
445
3076
337
2147
1.84
17.61
2.3
2.2
2.81
3.03
mg/l
1.11
288
1847
204
1114
2.03
16.82
1.4
1.3
759.20
488.17
titre
0.77
50
235
183
977
2.06
15.99
2.1
1.6
—
—
—
0
0
521
3859
1.70
15.59
7.4
6.2
1.21
1.21
mmol/l
0.88
482
3520
477
3455
1.70
15.47
2.2
2.0
95.84
94.87
pmol/l
0.16
260
1773
785
6525
1.84
15.42
9.1
7.6
78.12
79.01
u/l
0.27
743
6125
758
6299
1.76
14.12
5.3
4.1
12.17
12.26
mm/h
0.06
716
5794
255
1580
1.81
14.11
1.9
1.7
1187.90
1169.27
nmol/l
0.10
200
1190
203
1182
1.89
13.65
1.3
1.2
—
—
—
0
0
219
1311
1.85
13.49
2.9
2.5
13.47
12.98
umol/l
0.45
204
1223
130
650
2.14
13.40
3.2
2.9
10.57
10.58
g/l
0.00
119
595
364
2530
1.68
13.25
5.3
4.0
7.41
7.40
ph
0.72
66
478
277
1797
1.74
12.95
1.9
1.7
437.22
16205700.02
pmol/l
1.32
229
1481
168
941
1.94
12.64
3.5
2.7
2.05
1.80
%
1.46
159
845
78
324
2.52
12.33
1.3
1.2
5.58
1.16
u/ml
—
5
28
110
535
2.18
12.13
1.6
1.3
660.36
242.43
u/ml
1.76
105
487
940
8476
2.17
12.11
20.6
14.2
21.82
23.72
mg/l
1.03
764
6691
108
523
2.19
12.04
1.9
1.8
1.21
1.50
g/l
0.83
102
484
198
1204
1.80
11.43
2.4
2.0
—
—
—
0
0
60
228
2.73
11.34
1.3
1.1
49.17
4.42
u/ml
0.93
11
29
295
2019
1.64
11.02
1.7
1.5
20.03
20.68
nmol/l
0.33
263
1712
195
1195
1.78
10.93
3.0
2.5
2.34
2.33
g/l
0.07
183
1111
185
1120
1.79
10.80
2.9
2.5
22.71
22.87
%
0.05
155
966
762
6546
1.62
10.37
4.8
4.0
14.83
14.80
pmol/l
0.10
714
5914
111
577
2.03
10.27
3.1
2.6
—
—
—
0
0
322
2299
1.58
9.93
5.7
4.2
—
—
—
0
0
29
77
3.85
9.82
1.2
1.4
—
—
—
0
0
498
3931
1.51
9.64
14.9
14.6
1.26
1.23
inr
0.30
148
1160
549
4432
1.51
9.48
6.4
6.4
12.30
11.38
umol/l
0.83
511
4201
124
690
1.91
9.42
3.9
2.7
79.77
70.58
e9/l
1.71
98
531
28
75
3.81
9.37
1.2
1.4
0.46
0.39
g/l
0.35
21
52
28
75
3.81
9.37
1.2
1.4
7.64
6.68
g/l
0.64
20
54
28
75
3.81
9.37
1.2
1.4
2.68
2.73
g/l
0.05
21
52
480
3779
1.50
9.29
12.7
9.3
0.00
0.00
e9/l
0.25
398
3114
664
5608
1.51
9.00
5.5
4.5
3336.58
2144.33
e6/l
0.20
12
92
124
701
1.87
8.97
5.0
4.1
0.82
0.97
%
0.39
34
249
872
7843
1.70
8.91
5.8
4.7
1.96
2.07
mu/l
0.30
821
7149
118
661
1.89
8.78
5.0
4.2
0.13
0.12
%
0.07
31
209
122
691
1.87
8.77
3.3
2.9
67.13
66.51
g/l
0.38
115
628
134
784
1.81
8.68
2.7
2.1
340.81
371.36
nmol/l
1.19
125
724
345
2577
1.51
8.40
3.9
3.2
30.76
94.38
e6/l
1.70
281
2013
164
1027
1.71
8.39
1.6
1.4
—
—
—
0
0
321
2362
1.52
8.39
3.8
3.1
0.54
0.47
e6/l
0.10
258
1818
35
117
3.06
8.37
1.5
1.0
9.16
1.54
u/ml
1.36
15
50
944
8725
1.91
8.30
22.4
16.4
139.39
139.66
mmol/l
2.47
923
8488
37
129
2.94
8.24
1.6
1.6
0.78
0.75
g/l
0.08
28
101
392
3015
1.48
8.23
4.5
3.7
107.25
127.01
e6/l
0.15
306
2158
353
2665
1.49
8.10
3.5
3.1
7.31
7.50
mmol/l
0.32
305
2250
257
1818
1.55
8.00
3.2
2.5
5.86
5.77
e6/l
0.03
230
1648
597
4998
1.46
7.98
6.2
4.9
6.91
6.66
mmol/l
1.71
568
4691
75
371
2.10
7.94
1.9
2.0
1.32
1.47
g/l
0.79
64
331
212
1437
1.60
7.93
1.3
1.3
20.27
31.62
iu/ml
2.42
67
470
329
2468
1.49
7.72
3.4
3.2
1118.30
306.22
mg/l
1.08
213
1567
943
8746
1.86
7.71
22.8
16.5
3.96
3.97
mmol/l
0.40
923
8496
245
1732
1.54
7.60
3.6
2.9
504.66
544.51
mosm/kgh2o
2.30
213
1488
371
2859
1.46
7.56
3.2
3.4
2.35
2.35
mmol/l
0.66
337
2522
291
2140
1.50
7.49
7.6
6.6
—
—
—
0
0
109
627
1.83
7.45
5.2
4.2
0.39
0.63
%
0.15
23
174
410
3238
1.44
7.27
4.9
3.6
182.62
50.11
ng/l
0.45
289
2264
350
2690
1.45
7.15
3.2
2.5
68.41
90.06
u/l
0.31
323
2488
306
2294
1.47
7.10
3.8
3.0
—
—
—
0
0
202
1389
1.56
7.05
1.2
1.3
2.03
11.21
u/ml
5.74
73
531
130
803
1.71
6.96
2.6
2.3
0.21
0.21
g/l
0.49
124
755
821
7407
1.52
6.86
23.8
16.9
14.87
14.92
%
0.09
804
7285
52
238
2.25
6.70
3.8
3.2
—
—
—
0
0
418
3351
1.41
6.66
4.2
3.4
6.48
5.82
ph
2.58
23
242
108
641
1.76
6.66
5.0
4.0
0.44
0.57
%
0.36
27
209
344
2665
1.44
6.63
3.8
3.0
—
—
—
0
0
508
4215
1.40
6.62
4.7
3.7
0.00
0.01
estimate
0.80
98
770
23
70
3.34
6.44
2.0
2.2
1.02
1.25
e9/l
0.67
17
62
337
2614
1.43
6.41
3.9
3.8
11.76
8.83
mg/mmol
0.50
212
1626
137
877
1.65
6.40
1.8
1.6
—
—
—
0
0
200
1400
1.53
6.40
1.8
1.8
—
—
—
0
0
284
2137
1.45
6.36
2.9
2.7
3122.17
5953.27
umol/l
0.69
243
1873
82
454
1.88
6.34
1.3
1.3
—
—
—
0
0
500
4165
1.39
6.23
6.3
5.0
0.00
0.00
estimate
0.50
99
804
500
4167
1.39
6.20
4.7
3.7
0.01
0.00
estimate
0.41
104
851
49
227
2.22
6.16
1.4
1.2
2.97
9.13
u/ml
0.72
13
41
48
222
2.22
6.06
1.4
1.2
7.33
2.48
u/ml
0.41
11
25
671
5888
1.40
6.00
5.5
4.3
—
—
—
0
0
638
5561
1.38
5.88
3.8
3.2
52.64
48.97
u/l
0.53
598
5194
167
1145
1.55
5.85
1.8
1.6
—
—
—
0
0
326
2554
1.40
5.74
2.7
2.1
152.77
254.98
u/l
1.78
308
2399
164
1126
1.54
5.70
7.2
5.7
1.04
1.05
mmol/l
0.20
155
1043
13
20
6.57
5.56
3.0
2.4
101.67
295.00
e6/l
—
6
8
349
2790
1.38
5.38
3.4
3.3
32.39
32.34
u/l
0.01
328
2656
47
227
2.12
5.36
1.2
1.2
262.22
86.84
titre
—
9
19
198
1434
1.47
5.31
3.2
2.7
1.19
1.16
e6/l
0.03
127
834
189
1361
1.48
5.22
2.9
3.4
0.81
0.82
mmol/l
0.24
184
1283
952
9006
1.70
5.21
14.3
10.4
27.26
26.05
u/l
0.72
927
8674
40
186
2.20
5.03
2.0
1.7
—
—
—
0
0
244
1865
1.40
4.85
2.1
1.8
1.30
1.18
mg/l
0.15
189
1431
142
980
1.52
4.81
2.9
2.8
12.95
8.35
umol/l
0.94
121
839
984
9426
1.86
4.73
30.4
21.0
44.51
40.01
%
0.45
916
8797
984
9430
1.85
4.67
30.4
20.8
91.50
90.98
fl
2.83
970
9285
36
166
2.21
4.63
1.9
1.4
—
—
—
0
0
984
9432
1.85
4.63
30.5
20.9
4.40
4.48
e12/l
4.69
953
9173
984
9432
1.85
4.63
30.5
20.9
6.71
6.72
e9/l
0.03
954
9172
984
9436
1.84
4.57
30.6
21.0
132.93
134.85
g/l
4.13
969
9287
983
9427
1.82
4.51
30.5
20.9
247.93
250.20
e9/l
0.49
954
9192
983
9431
1.81
4.45
30.4
20.8
30.43
30.29
pg
1.70
970
9284
288
2292
1.36
4.43
4.9
4.0
0.00
0.01
estimate
1.08
96
781
250
1946
1.38
4.42
4.3
3.7
—
—
—
0
0
106
701
1.57
4.35
4.3
3.7
1.24
1.23
mmol/l
0.78
95
595
934
8854
1.55
4.34
20.2
13.5
—
—
—
0
0
138
969
1.49
4.30
8.0
8.2
1.46
1.25
mmol/l
0.34
117
777
19
67
2.87
4.24
1.2
1.2
339.15
374.93
nmol/l
0.26
13
59
142
1006
1.48
4.24
2.1
2.3
125.71
123.06
ug/g
0.04
110
785
213
1627
1.39
4.21
4.6
3.8
187.76
360.70
ng/l
1.12
149
1254
299
2414
1.34
4.14
3.4
3.1
1221.02
1286.21
ng/l
0.16
267
2065
21
80
2.66
4.08
3.9
2.5
—
—
—
0
0
50
275
1.86
4.03
1.2
1.3
—
—
—
0
0
107
722
1.54
4.03
2.4
2.5
7.05
7.01
ug/l
0.01
92
640
664
5984
1.30
4.03
4.2
3.8
—
—
—
0
0
16
53
3.05
3.97
2.4
2.3
0.28
0.22
e9/l
—
10
46
89
583
1.58
3.82
7.1
5.4
—
—
—
0
0
104
706
1.53
3.82
4.3
3.4
—
—
—
0
0
464
4025
1.28
3.66
2.6
2.6
—
—
—
0
0
15
51
2.97
3.58
1.1
1.0
—
—
—
0
0
113
795
1.47
3.50
4.9
3.7
2.33
1.98
mmol/l
0.41
95
655
29
139
2.12
3.46
1.1
1.1
—
—
—
0
0
55
328
1.71
3.43
5.8
4.9
—
—
—
0
0
259
2098
1.31
3.43
4.8
4.0
90.71
91.06
%
0.08
250
2048
100
690
1.50
3.42
4.3
3.1
179.78
207.76
ng/l
0.28
92
635
235
1882
1.32
3.37
5.0
4.0
1.02
1.02
kg/l
0.08
35
267
771
7157
1.30
3.37
26.2
18.5
331.90
332.29
g/l
0.57
762
7111
22
95
2.34
3.35
1.3
1.2
—
—
—
0
0
175
1342
1.37
3.35
3.3
2.9
3.39
2.63
e6/l
0.44
105
742
14
48
2.94
3.31
1.1
1.0
—
—
—
0
0
199
1561
1.34
3.29
2.6
2.9
2.44
2.45
mmol/l
0.66
177
1370
105
741
1.46
3.22
9.2
7.7
10.18
9.53
mmol/l
0.40
96
709
12
34
3.56
3.20
1.3
1.1
1616.00
1611.82
miu/ml
0.00
12
34
870
8231
1.35
3.20
5.1
4.5
6.02
5.92
mmol/l
1.26
814
7494
15
55
2.75
3.16
2.4
2.3
336.22
616.65
e6/l
—
9
46
828
7783
1.32
3.14
6.9
5.7
40.57
39.80
mmol/mol
1.28
774
7193
83
564
1.51
3.07
3.4
4.1
7.42
7.41
ph
—
9
69
16
62
2.61
3.05
1.2
2.0
48.16
37.32
%
2.57
16
62
83
565
1.51
3.04
2.6
2.8
4.99
6.81
e9/l
0.53
71
462
27
134
2.04
2.98
2.3
2.0
—
—
—
0
0
21
95
2.24
2.91
1.4
1.6
—
—
—
0
0
31
164
1.92
2.88
1.3
1.3
211.69
247.84
u/ml
0.33
18
99
98
700
1.44
2.84
7.8
8.7
—
—
—
0
0
27
137
2.00
2.82
1.1
1.2
3.10
6.60
u/ml
—
10
63
36
202
1.81
2.80
1.8
1.7
25361.43
15643.75
e6/l
0.25
30
150
877
8348
1.33
2.77
4.9
4.4
4.52
4.66
mmol/l
3.93
818
7751
274
2296
1.26
2.72
1.7
1.7
1.35
1.38
mmol/l
0.22
240
1916
389
3393
1.23
2.70
2.1
2.1
—
—
—
0
0
74
506
1.50
2.68
3.1
3.3
4.37
4.57
pmol/l
1.09
61
446
890
8501
1.33
2.65
5.3
4.9
2.66
2.75
mmol/l
2.35
827
7843
11
35
3.17
2.65
1.4
3.5
676.82
804.34
u/ml
0.23
11
35
18
80
2.27
2.61
1.7
1.3
8990.00
121366.35
e6/l
—
9
60
47
733
0.62
2.60
1.6
1.4
—
—
—
0
0
28
149
1.90
2.58
2.2
1.4
122.14
112.72
u/ml
—
7
29
49
308
1.62
2.57
2.0
2.4
22.68
21.44
s
0.18
41
279
18
81
2.24
2.55
1.1
1.2
—
—
—
0
0
21
101
2.10
2.54
1.9
2.6
14.83
7.80
umol/l
0.45
16
66
66
447
1.51
2.52
11.3
11.0
—
—
—
0
0
18
82
2.22
2.48
1.3
1.4
—
—
—
0
0
23
116
2.01
2.47
2.5
2.1
—
—
—
0
0
10
32
3.15
2.44
1.1
1.5
—
—
—
0
0
21
103
2.06
2.43
1.2
1.2
—
—
—
0
0
103
765
1.38
2.43
2.3
2.4
32.64
33.31
u/l
0.07
90
643
61
412
1.51
2.37
4.6
3.5
25.25
25.15
mmol/l
0.11
61
398
27
147
1.86
2.34
1.2
1.4
—
—
—
0
0
73
514
1.45
2.32
1.3
1.3
—
43.77
—
0
34
840
7997
1.27
2.31
4.4
3.9
1.24
1.28
mmol/l
1.13
780
7329
162
1299
1.29
2.29
2.0
2.2
29.56
29.73
s
0.15
154
1254
25
134
1.89
2.28
2.1
1.6
—
—
—
0
0
6
13
4.64
2.27
2.3
1.8
—
—
—
0
0
34
201
1.71
2.27
2.1
2.0
—
—
—
0
0
78
560
1.42
2.24
1.5
1.4
—
—
—
0
0
9
29
3.12
2.23
1.0
1.3
—
—
—
0
0
10
35
2.87
2.21
1.0
2.0
31.90
30.17
umol/l
—
10
35
8
24
3.35
2.18
6.5
4.3
—
—
—
0
0
42
266
1.60
2.18
1.2
1.2
—
—
—
0
0
7
19
3.70
2.15
1.0
1.1
—
—
—
0
0
30
174
1.75
2.15
3.6
2.4
15.12
16.55
%
1.06
15
90
24
130
1.87
2.13
1.4
1.5
—
—
—
0
0
9
32
2.83
2.00
1.8
2.8
—
—
—
0
0
39
250
1.58
1.95
1.2
1.4
204.60
240.69
miu/ml
0.35
15
123
9
33
2.74
1.93
2.6
2.0
—
—
—
0
0
864
8297
1.25
1.92
4.8
4.4
1.46
1.48
mmol/l
0.59
803
7649
308
2702
1.20
1.91
2.5
2.4
—
—
—
0
0
45
301
1.52
1.88
1.6
1.6
—
—
—
0
0
9
34
2.66
1.86
1.2
1.2
—
—
—
0
0
39
253
1.56
1.86
2.3
2.3
4199.58
2621.18
u/l
0.21
16
109
90
685
1.34
1.86
5.0
3.9
123.33
82.25
ng/l
1.41
78
608
25
144
1.75
1.86
1.7
1.6
—
—
—
0
0
93
712
1.34
1.85
1.6
1.7
—
—
—
0
0
7
23
3.06
1.80
1.0
1.5
—
—
—
0
0
20
109
1.85
1.78
2.6
1.9
33.45
32.78
pg
0.36
20
109
35
225
1.57
1.75
2.7
3.8
8.71
8.27
kpa
0.72
35
219
14
68
2.07
1.70
1.0
1.0
273.21
286.02
mg/l
0.21
14
62
38
251
1.53
1.70
1.6
1.4
273.63
298.67
ug/g
0.25
19
152
36
236
1.54
1.67
2.3
1.6
—
—
—
0
0
10
40
2.51
1.67
1.2
1.3
133.20
150.36
nmol/l
—
10
40
6
19
3.17
1.66
1.8
1.1
35.00
27.09
%
—
6
11
8
31
2.59
1.66
1.8
1.5
—
—
—
0
0
235
2043
1.19
1.59
2.3
2.3
—
—
—
0
0
41
280
1.48
1.59
2.1
1.6
—
—
—
0
0
44
305
1.46
1.59
2.0
1.6
—
—
—
0
0
6
20
3.01
1.58
1.8
3.5
—
35.60
—
0
5
11
50
2.21
1.57
2.1
1.4
—
—
—
0
0
44
306
1.46
1.56
2.0
1.6
—
—
—
0
0
33
216
1.55
1.55
1.1
1.1
—
—
—
0
0
5
15
3.34
1.52
1.6
1.2
—
—
—
0
0
44
308
1.45
1.52
2.1
1.6
—
—
—
0
0
7
27
2.60
1.51
1.3
1.1
—
—
—
0
0
39
268
1.47
1.48
1.8
1.5
346.82
288.03
mu/l
0.67
34
241
257
2267
1.18
1.47
4.7
3.4
—
—
—
0
0
16
87
1.85
1.46
3.3
2.6
0.71
1.54
g/24h
—
7
43
7
28
2.51
1.45
1.1
1.0
—
—
—
0
0
6
22
2.74
1.43
1.7
1.5
64.83
77.95
nmol/24h
—
6
22
6
22
2.74
1.43
2.2
1.4
—
—
—
0
0
9
39
2.32
1.43
2.7
1.9
—
—
—
0
0
43
304
1.43
1.42
2.1
1.6
—
—
—
0
0
93
742
1.28
1.42
4.7
3.8
—
—
—
0
0
18
103
1.76
1.41
1.2
1.5
0.24
0.33
nmol/l
0.56
11
83
35
239
1.48
1.38
1.3
1.2
—
—
—
0
0
43
307
1.42
1.36
6.7
3.2
0.35
0.28
g/l
0.20
23
123
27
176
1.55
1.32
6.8
4.2
3.38
2.68
mmol/l
0.76
20
120
15
83
1.82
1.31
3.5
2.9
—
—
—
0
0
15
83
1.82
1.31
2.2
2.5
—
—
—
0
0
12
62
1.95
1.28
1.0
1.1
—
1.85
—
0
11
17
99
1.73
1.27
1.2
1.1
—
—
—
0
0
11
55
2.01
1.27
1.0
1.7
14.15
13.14
umol/l
0.11
11
50
8
35
2.30
1.27
1.1
1.1
—
19.83
—
0
6
9
44
2.05
1.27
1.7
1.2
—
—
—
0
0
30
204
1.48
1.23
2.4
2.3
228.25
86.37
ug/min
0.34
16
122
15
85
1.78
1.23
1.2
1.1
—
—
—
0
0
29
196
1.49
1.23
6.6
4.1
—
—
—
0
0
42
307
1.38
1.19
1.1
1.1
—
—
—
0
0
21
133
1.59
1.18
1.1
1.1
—
—
—
0
0
8
39
2.06
1.15
1.4
1.3
145.05
169.25
mmol/24h
—
8
39
5
20
2.51
1.15
1.4
1.3
—
—
—
0
0
10
51
1.97
1.11
4.0
1.5
—
—
—
0
0
75
604
1.26
1.10
1.5
1.4
—
—
—
0
0
28
193
1.46
1.10
1.4
1.6
36.81
10.36
e6/l
0.37
21
149
28
193
1.46
1.10
1.4
1.6
33792.86
699.33
e6/l
0.47
22
154
30
211
1.43
1.07
1.8
1.8
3.86
4.84
iu/l
—
10
71
54
421
1.30
1.03
4.0
4.3
—
—
—
0
0
5
22
2.28
1.03
1.4
1.4
—
—
—
0
0
15
91
1.66
1.01
1.7
1.3
—
—
—
0
0
19
123
1.55
1.00
1.3
1.2
—
—
—
0
0
111
945
1.20
0.99
1.2
1.3
—
—
—
0
0
35
258
1.37
0.98
7.9
3.8
48.96
80.14
mg/l
0.61
28
204
35
258
1.37
0.98
7.9
3.8
40.06
43.69
mg/l
0.10
28
206
15
92
1.64
0.97
1.5
1.6
—
—
—
0
0
109
928
1.20
0.97
1.7
1.6
—
—
—
0
0
44
337
1.32
0.97
1.3
1.4
30.71
30.07
iu/l
0.04
38
282
9
50
1.81
0.96
13.8
21.5
1249.89
1651.42
nmol/l
—
9
50
13
78
1.68
0.91
1.4
1.1
—
—
—
0
0
32
236
1.37
0.90
6.8
4.6
—
—
—
0
0
54
433
1.26
0.86
5.9
3.5
—
—
—
0
0
19
128
1.49
0.86
1.0
1.0
7.59
5.12
u/ml
—
8
63
88
745
1.20
0.85
1.4
1.4
—
—
—
0
0
269
2475
1.12
0.83
4.9
3.8
—
—
—
0
0
21
146
1.45
0.83
1.2
1.2
—
—
—
0
0
16
105
1.53
0.82
1.4
1.3
—
—
nmol/l
—
0
0
25
181
1.39
0.80
5.6
3.6
—
—
—
0
0
18
122
1.48
0.80
2.6
2.8
—
—
—
0
0
40
313
1.29
0.79
5.3
4.0
1.37
1.33
mmol/l
0.13
40
306
13
82
1.59
0.78
1.1
2.0
—
—
—
0
0
13
82
1.59
0.78
1.7
1.3
5.84
6.64
mmol/l
0.64
13
74
9
54
1.67
0.74
1.1
2.2
—
—
—
0
0
34
263
1.30
0.74
11.7
11.1
—
—
—
0
0
46
371
1.25
0.73
2.6
1.8
—
—
—
0
0
22
159
1.39
0.72
1.6
3.7
268.64
1807.97
u/ml
0.50
22
150
7
39
1.80
0.72
54.4
27.6
7.29
7.03
ug/l
—
7
34
7
39
1.80
0.72
2.3
2.8
51342.86
39510.38
ug/l
—
7
39
13
84
1.55
0.72
2.7
2.5
—
—
—
0
0
5
26
1.93
0.70
1.0
2.4
—
—
—
0
0
22
160
1.38
0.70
2.5
2.6
—
—
—
0
0
13
85
1.54
0.69
1.7
1.3
31355.71
105789.40
e6/l
—
7
52
5
27
1.86
0.68
1.4
1.1
—
—
—
0
0
11
69
1.60
0.68
1.5
1.2
—
—
—
0
0
7
42
1.67
0.68
2.0
3.2
—
—
—
0
0
12
78
1.54
0.65
1.4
1.2
—
—
—
0
0
5
29
1.73
0.64
2.2
1.4
—
—
—
0
0
12
79
1.53
0.62
1.7
1.3
—
—
—
0
0
27
208
1.31
0.62
1.4
1.4
13.95
10.20
u/l
0.47
22
164
8
50
1.60
0.61
1.5
1.2
—
—
—
0
0
8
51
1.57
0.60
2.0
1.6
7.33
9.54
mmol/l
—
8
51
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
2.2
—
—
—
0
0
23
174
1.33
0.60
1.1
1.7
—
—
—
0
0
19
140
1.36
0.58
1.5
1.4
—
—
—
0
0
20
151
1.33
0.54
1.7
1.8
193.65
205.80
pmol/l
0.24
20
143
17
125
1.37
0.54
1.1
1.0
0.47
0.78
u/ml
—
7
54
15
108
1.39
0.53
3.1
2.6
—
—
—
0
0
18
134
1.35
0.53
1.7
2.7
—
—
—
0
0
13
91
1.43
0.53
1.3
2.1
—
—
—
0
0
19
143
1.33
0.52
1.0
1.1
0.64
3.32
u/ml
—
8
75
20
153
1.31
0.50
2.9
2.5
—
—
—
0
0
23
180
1.28
0.50
3.8
3.2
0.81
0.86
nmol/l
0.20
17
140
7
46
1.53
0.48
1.7
2.2
—
51.14
—
0
5
98
883
1.12
0.48
3.4
4.3
6.78
24.87
ug/l
1.07
84
727
7
47
1.49
0.47
8.7
7.2
—
—
—
0
0
10
68
1.48
0.47
1.1
1.4
—
—
—
0
0
52
450
1.16
0.45
2.4
2.4
—
—
—
0
0
270
2559
1.07
0.45
4.4
4.9
1.75
2.56
ug/l
3.09
244
2280
68
603
1.14
0.43
1.2
1.2
75.31
128.77
iu/ml
0.73
30
232
91
823
1.12
0.43
5.4
4.2
—
—
—
0
0
12
87
1.38
0.42
1.8
1.4
—
—
—
0
0
14
105
1.34
0.41
1.4
1.3
—
—
—
0
0
5
34
1.47
0.40
1.2
1.1
137.12
170.49
iu/ml
—
5
34
22
178
1.24
0.39
1.2
1.3
—
—
—
0
0
9
67
1.35
0.38
1.1
1.2
—
—
—
0
0
245
2334
1.07
0.36
1.5
1.4
—
—
—
0
0
6
43
1.40
0.35
1.3
1.3
—
—
—
0
0
13
100
1.30
0.33
6.4
4.0
—
—
—
0
0
6
89
0.67
0.33
2.5
2.0
—
—
—
0
0
13
101
1.29
0.31
1.0
1.0
20.52
3.53
u/ml
—
5
46
309
2981
1.05
0.30
3.3
2.9
—
—
—
0
0
7
54
1.30
0.30
1.1
1.0
—
—
—
0
0
12
152
0.79
0.29
1.2
1.7
—
—
—
0
0
15
121
1.24
0.28
1.0
1.1
4.46
1.71
u/ml
—
9
62
13
162
0.80
0.28
1.2
1.1
—
—
—
0
0
23
195
1.18
0.28
3.2
3.8
26.41
27.38
mg/l
0.06
17
124
43
477
0.90
0.26
1.3
1.4
—
—
—
0
0
25
216
1.16
0.25
1.7
1.7
52.48
41.17
nmol/l
1.07
25
209
16
133
1.21
0.24
1.1
1.1
14.20
67.38
iu/ml
—
5
26
76
816
0.93
0.24
1.4
1.4
—
—
—
0
0
58
533
1.09
0.24
1.1
1.2
—
—
—
0
0
35
390
0.89
0.23
2.2
1.7
—
—
—
0
0
21
181
1.16
0.22
4.2
2.6
—
—
—
0
0
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.36
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
16.80
—
0
10
0
10
0.00
0.21
0.0
4.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
5
43
1.16
0.21
2.0
2.5
—
—
—
0
0
11
89
1.24
0.21
1.2
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
6.4
—
—
—
0
0
6
48
1.25
0.20
1.2
1.1
—
—
—
0
0
6
52
1.15
0.19
2.2
2.9
—
—
—
0
0
16
137
1.17
0.19
1.3
1.1
—
—
—
0
0
29
321
0.90
0.18
2.6
2.7
—
—
—
0
0
7
60
1.17
0.18
3.7
3.2
—
—
—
0
0
16
138
1.16
0.17
1.3
1.1
—
—
—
0
0
113
1086
1.05
0.15
1.2
1.3
—
—
—
0
0
14
122
1.15
0.13
1.1
1.2
—
—
—
0
0
8
98
0.81
0.13
1.3
1.2
—
—
—
0
0
59
562
1.05
0.11
3.2
2.7
—
—
—
0
0
17
154
1.11
0.10
1.3
1.2
—
—
—
0
0
32
339
0.94
0.09
1.1
1.1
—
—
—
0
0
145
1482
0.97
0.08
3.0
3.0
0.63
0.76
ug/l
1.01
103
966
7
67
1.05
0.08
1.7
1.1
—
—
—
0
0
76
775
0.98
0.04
1.7
1.4
—
—
—
0
0
13
137
0.95
0.01
1.9
1.5
—
—
—
0
0
20
207
0.97
0.01
1.5
1.3
—
—
—
0
0
13
132
0.98
0.00
1.8
1.4
—
—
—
0
0
13
132
0.98
0.00
1.8
1.4
—
—
—
0
0
22
218
1.01
0.00
3.4
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
6
63
0.95
0.00
3.3
2.1
11.35
10.80
%
—
6
63
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
95.63
—
0
8
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
191.33
—
0
6
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
2.10
—
0
5
5
51
0.98
-0.00
1.2
1.3
245.00
158.26
pmol/l
—
5
51
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_BULLOTH and mortality.

Females

Parameter HR [95% CI] p-value
L12_BULLOTH 1.288 [1.11, 1.49] < 0.001
Birth year 1.001 [0.99, 1.01] 0.879

During the follow-up period (1.1.1998 — 31.12.2019), 519 out of 2922 females with L12_BULLOTH died.

Males

Parameter HR [95% CI] p-value
L12_BULLOTH 1.22 [1.06, 1.4] 0.006
Birth year 0.991 [0.98, 1.0] 0.041

During the follow-up period (1.1.1998 — 31.12.2019), 526 out of 2437 males with L12_BULLOTH died.

Mortality risk

Mortality risk for people of age

years, who have L12_BULLOTH.

N-year risk Females Males
1 0.1% 0.243%
5 0.847% 1.526%
10 2.264% 3.883%
15 4.52% 7.531%
20 7.761% 13.074%

Relationships between endpoints

Index endpoint: L12_BULLOTH – Other bullous disorders

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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