vesiculobullous skin disease: Skin diseases characterized by local or general distributions of vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, distinguished by size (vesicles being less than 5–10 mm and bullae being larger than 5–10 mm). Vesiculobullous diseases are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. (From Scientific American Medicine, 1990, and Wikipedia)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
384 |
4. Check minimum number of eventsNone |
384 |
5. Include endpointsNone |
384 |
6. Filter based on genotype QC (FinnGen only) |
376 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF6
- Parent code in ICD-10
- L10-L14
- Name in latin
- Aliae morbositates bullosae
Similar endpoints
↥List of similar endpoints to
Other and unspecified bullous disorders
based on the number of shared cases.
Similar with more cases:
- Other bullous disorders
- Bullous disorders
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2861 | 1586 | 1258 |
| Only index persons | 2371 | 1363 | 1008 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 55.73 | 56.47 | 54.87 |
| Only index persons | 56.95 | 56.76 | 57.21 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 376 | 235 | 141 |
| Unadjusted period prevalence (%) | 0.08 | 0.08 | 0.06 |
| Median age at first event (years) | 61.80 | 60.00 | 64.81 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 384
- Matched controls
- 3840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L13.9
ICD-10 Finland
Bullous disorder, unspecified
6796.8
307.7
302
*
L13.8
ICD-10 Finland
Other specified bullous disorders
289.3
72.0
71
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
7.6
63.7
108
187
L12.0
ICD-10 Finland
Bullous pemphigoid
623.2
56.1
54
*
TQW80
NOMESCO Finland
Local dermatologic skincare
14.7
51.2
48
37
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.9
47.8
148
436
J04BA02
ATC
dapsone; oral
185.9
33.3
34
*
D07AC01
ATC
betamethasone; topical
3.4
30.4
198
922
D07AD01
ATC
clobetasol; topical
3.9
30.1
113
370
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.2
29.7
95
277
L13.0
ICD-10 Finland
Dermatitis herpetiformis
290.3
27.1
27
*
XQ848
NOMESCO Finland
Dermatological photography
8.3
22.0
30
39
L12.9
ICD-10 Finland
Pemphigoid, unspecified
110.8
19.8
21
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
5.3
19.2
41
85
E0000UV, ,
ATC
2.5
18.0
201
1157
H02AB06
ATC
prednisolone; systemic
2.5
17.8
221
1334
L04AX03
ATC
methotrexate; systemic
3.6
17.8
65
204
A46
ICD-10 Finland
Erysipelas
3.1
16.1
80
303
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
15.8
166
914
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.5
15.1
56
177
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.0
14.5
75
289
D07AC13
ATC
mometasone; topical
2.4
14.1
138
730
J01FF01
ATC
clindamycin; systemic
2.4
13.6
128
664
E000001, ,
ATC
2.5
13.5
102
478
D07AB08
ATC
desonide; topical
3.0
13.2
65
243
D07BC01
ATC
betamethasone and antiseptics; topical
3.0
13.0
63
234
R06AE07
ATC
cetirizine; oral
2.2
12.8
193
1211
H02AB09
ATC
hydrocortisone; systemic
6.5
12.6
21
34
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.6
12.5
24
45
XQ802
NOMESCO Finland
Epicutan test
4.6
12.4
30
69
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.9
11.8
63
246
L04AX01
ATC
azathioprine; systemic
4.6
11.6
28
64
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
11.6
68
279
J01DB01
ATC
cefalexin; oral
2.7
10.9
332
2687
R60.0
ICD-10 Finland
Localized oedema
2.7
10.8
63
258
WZC00
NOMESCO Finland
Treatment plan or consultation
2.1
10.8
155
939
L30.3
ICD-10 Finland
Infective dermatitis
4.9
10.6
24
52
D07AB02
ATC
hydrocortisone butyrate; topical
2.1
10.5
132
759
J05AB11
ATC
valaciclovir; oral
2.5
10.4
78
360
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.7
10.4
60
244
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.7
10.3
59
239
C03CA01
ATC
furosemide; systemic
2.1
10.2
133
773
S18
ICPC
Laceration/cut
2.0
10.1
192
1277
D02AX
ATC
Other emollients and protectives
4.5
10.0
25
59
ZX120
NOMESCO Finland
Intravenous
2.9
10.0
52
200
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.6
9.9
24
55
J01CF05
ATC
flucloxacillin; systemic
3.3
9.9
38
122
S97
ICPC
Chronic ulcer skin
3.3
9.9
38
122
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.8
9.7
53
209
H02AB04
ATC
methylprednisolone; systemic
2.4
9.4
71
328
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
9.4
127
745
S29
ICPC
Skin symptom/complaint other
2.2
9.4
89
455
R06.0
ICD-10 Finland
Dyspnoea
2.1
9.2
120
693
D07XC01
ATC
betamethasone; topical
2.6
9.1
57
241
L13
ICD-10 Finland
Other bullous disorders
37.6
9.1
11
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.4
9.0
33
103
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.8
9.0
47
181
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.4
8.9
33
104
R50.9
ICD-10 Finland
Fever, unspecified
2.3
8.8
73
352
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.2
8.6
23
57
K90.0
ICD-10 Finland
Coeliac disease
4.5
8.5
21
49
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.7
8.5
49
199
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.4
8.4
64
296
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
8.4
85
444
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
8.3
106
604
Z01.8
ICD-10 Finland
Other specified special examinations
2.1
8.2
95
522
L29.9
ICD-10 Finland
Pruritus, unspecified
4.7
8.2
19
42
A02BC02
ATC
pantoprazole; systemic
1.9
8.2
265
2052
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.7
8.1
26
74
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
4.3
8.1
21
51
Z3231
NOMESCO Finland
Registered nurse
2.0
8.1
121
730
J01MA02
ATC
ciprofloxacin; systemic
1.9
8.0
157
1033
Z71.8
ICD-10 Finland
Other specified counselling
1.9
8.0
130
806
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
3.1
8.0
35
122
A10AE04
ATC
insulin glargine; parenteral
2.6
7.9
47
193
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
7.9
63
298
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
6.9
7.7
18
27
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.0
7.5
106
625
N02BE01
ATC
paracetamol; systemic, rectal
2.5
7.4
345
2982
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
7.4
183
1286
R60.9
ICD-10 Finland
Oedema, unspecified
3.3
7.3
28
90
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
7.3
63
308
J01MA12
ATC
levofloxacin; systemic
2.1
7.3
79
423
K11.70
ICD-10 Finland
Hypoptyalism
30.6
7.2
9
*
S17
ICPC
Abrasion/scratch/blister
4.2
7.2
19
47
L04AA13
ATC
[U] leflunomide
6.2
7.2
18
30
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
7.0
110
669
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.9
6.9
120
753
ZY010
NOMESCO Finland
Hospital outpatient
3.0
6.9
30
104
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.6
6.8
22
63
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.5
6.8
43
183
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.9
6.7
32
117
D05AX52
ATC
calcipotriol, combinations; topical
3.2
6.7
26
84
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
6.7
83
465
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
6.7
78
428
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.2
6.6
26
85
E66.8
ICD-10 Finland
Other obesity
3.3
6.6
25
80
SPAT1229
SPAT
Assessment of need for aid
2.6
6.5
37
149
R52.9
ICD-10 Finland
Pain, unspecified
2.4
6.4
47
213
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.2
6.4
17
42
D05BB02
ATC
acitretin; oral
5.3
6.4
18
35
L01BA01
ATC
methotrexate; systemic
3.7
6.4
20
56
D09AB01
ATC
zinc bandage without supplements; topical
8.4
6.4
13
16
SPAT1149
SPAT
Suture or treatment of traumatic wound
2.3
6.3
53
255
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.9
6.3
98
593
A10AB05
ATC
insulin aspart; parenteral
2.5
6.3
39
164
SPAT1099
SPAT
Measurement of blood pressure with Doppler ultrasound device
3.8
6.3
19
52
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.9
6.3
30
110
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.4
6.3
44
196
L51.9
ICD-10 Finland
Erythema multiforme, unspecified
27.2
6.3
8
*
K03.66
ICD-10 Finland
Tooth plaque
2.6
6.2
36
146
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
6.2
68
364
WZC30
NOMESCO Finland
Teaching
2.1
6.2
66
350
R07.4
ICD-10 Finland
Chest pain, unspecified
1.8
6.2
115
735
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
6.2
57
286
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.1
89
526
S76
ICPC
Skin infection other
3.0
6.1
27
95
L17
ICPC
Foot/toe symptom/complaint
1.8
6.0
119
773
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
95
17
73.92
172.88
1.8
1.1
32.07
—
u/ml
—
28
0
82
22
47.12
135.94
1.4
1.2
801.43
—
titre
—
7
0
280
1848
2.90
19.49
14.4
9.0
4.32
4.03
e9/l
1.30
255
1622
238
1483
2.59
17.97
10.0
5.6
2.99
2.85
%
0.49
227
1388
242
1530
2.57
17.56
10.1
5.8
27.18
28.71
%
1.07
230
1444
238
1511
2.51
16.83
9.7
5.6
58.18
56.47
%
1.20
226
1424
239
1554
2.42
15.53
10.1
6.6
1.21
1.22
mmol/l
1.05
221
1334
209
1337
2.24
13.36
6.5
4.5
34.01
35.69
g/l
3.83
197
1256
195
1220
2.22
13.09
2.3
2.0
96.35
96.09
pmol/l
0.02
110
629
25
26
10.20
12.93
1.3
1.3
—
—
—
0
0
139
784
2.21
11.81
2.4
2.1
3.07
3.14
mg/l
0.12
122
676
72
305
2.67
11.56
3.5
1.8
334.49
387.27
nmol/l
1.55
67
278
179
1126
2.10
11.39
5.1
3.8
122.31
133.59
e6/l
0.04
142
797
158
963
2.09
10.80
4.2
3.2
31.22
123.20
e6/l
0.75
135
746
130
740
2.14
10.60
1.6
1.2
2.32
1.51
u/ml
0.43
35
195
306
2414
2.32
10.12
11.8
7.4
81.32
80.63
u/l
0.11
294
2263
143
867
2.03
9.69
4.3
3.1
0.22
0.55
e6/l
1.96
120
650
206
1431
1.95
9.32
9.2
5.8
1.21
1.22
mmol/l
1.02
195
1307
297
2346
2.17
9.30
6.3
4.1
13.61
12.02
mm/h
1.04
287
2151
171
1123
1.94
9.08
4.8
3.2
—
—
—
0
0
65
296
2.44
8.88
5.5
3.9
2.78
1.97
mmol/l
0.89
55
242
187
1273
1.91
8.84
2.9
2.3
78.60
76.17
nmol/l
0.58
170
1138
96
517
2.14
8.82
3.7
2.9
1.43
1.09
e6/l
0.34
68
291
197
1376
1.89
8.50
3.9
2.6
140.12
118.43
ug/l
0.52
188
1274
17
20
8.84
8.39
1.1
1.2
—
—
—
0
0
75
373
2.26
8.36
7.2
6.7
103.49
103.89
mmol/l
0.23
75
373
71
346
2.29
8.30
1.9
1.9
—
—
—
0
0
113
660
2.01
8.30
3.0
2.5
6.13
5.46
e6/l
0.18
101
598
93
509
2.09
8.13
3.8
2.2
11.87
13.28
umol/l
1.29
87
474
361
3168
3.33
7.99
27.0
13.8
22.46
22.73
mg/l
0.05
303
2499
121
737
1.94
7.80
1.8
1.6
19.60
21.33
nmol/l
0.59
110
623
90
494
2.07
7.78
3.9
3.1
3.47
2.48
e6/l
0.52
62
270
265
2071
1.90
7.70
6.1
4.5
5554.60
2207.49
e6/l
—
5
35
67
330
2.25
7.61
5.3
4.3
239.78
243.52
u/l
0.09
67
316
114
689
1.93
7.48
2.3
1.9
1.73
1.16
mg/l
0.44
94
537
50
220
2.46
7.32
1.9
1.6
—
—
—
0
0
199
1439
1.79
7.29
14.8
13.1
1.21
1.23
inr
0.07
55
429
69
350
2.18
7.28
2.0
2.0
—
—
—
0
0
222
1663
1.79
7.17
7.8
6.2
11.53
11.73
umol/l
0.10
214
1573
361
3223
3.00
6.65
27.5
16.0
139.13
139.69
mmol/l
3.25
355
3139
325
2778
2.11
6.56
30.0
16.6
15.02
14.98
%
0.04
319
2744
88
508
1.95
6.52
2.5
1.9
—
—
—
0
0
10
7
14.62
6.43
1.0
1.0
—
—
—
0
0
143
967
1.76
6.37
3.9
3.0
6.76
7.41
mmol/l
0.97
128
816
140
944
1.76
6.28
4.2
3.7
14.64
9.43
mg/mmol
0.42
93
572
41
177
2.47
6.25
2.3
2.8
0.51
0.19
e6/l
0.92
41
172
135
905
1.76
6.16
3.8
3.2
1243.06
1292.38
ng/l
0.07
120
777
36
147
2.60
6.15
4.1
3.1
0.81
0.67
%
1.21
36
147
10
8
12.79
6.11
1.1
1.0
108.00
81.38
%
—
10
8
204
1535
1.70
6.10
5.1
3.8
0.03
0.00
estimate
0.41
35
304
360
3236
2.80
6.03
28.1
16.0
3.95
3.98
mmol/l
1.05
354
3147
96
585
1.85
5.99
2.0
1.7
1135.02
1174.75
nmol/l
0.13
78
439
168
1205
1.70
5.97
5.0
3.8
359.28
65.87
ng/l
0.42
124
829
77
438
1.95
5.92
3.8
2.2
20.48
22.81
%
0.90
68
381
206
1563
1.69
5.90
5.1
3.8
0.00
0.01
estimate
0.50
30
271
204
1545
1.68
5.88
7.2
5.0
0.00
0.00
estimate
-0.00
32
286
13
19
7.04
5.78
1.2
2.3
—
—
—
0
0
59
312
2.05
5.55
4.6
3.4
—
—
—
0
0
135
929
1.70
5.49
3.0
2.1
143.28
252.55
u/l
0.85
127
877
193
1460
1.65
5.44
2.9
2.6
—
—
—
0
0
9
8
11.48
5.31
1.0
1.0
—
—
—
0
0
31
128
2.55
5.19
3.0
2.0
7.07
7.43
g/l
0.65
31
117
31
128
2.55
5.19
3.0
2.0
—
—
—
0
0
31
128
2.55
5.19
3.0
2.0
3.50
3.63
g/l
0.20
31
117
29
116
2.62
5.17
3.1
2.1
8.30
10.59
g/l
3.52
29
104
148
1057
1.65
5.17
4.2
3.2
2.35
2.36
mmol/l
0.29
133
934
100
645
1.74
5.09
2.0
1.8
412.66
10694619.43
pmol/l
0.50
85
533
115
774
1.69
5.01
3.7
2.7
7287.49
6451.24
umol/l
0.06
97
662
232
1861
1.62
4.99
6.9
4.5
7.17
6.63
mmol/l
2.45
224
1725
21
72
3.03
4.95
1.6
1.2
—
—
—
0
0
14
29
4.97
4.85
1.1
1.2
—
—
—
0
0
363
3330
2.65
4.81
18.0
10.3
25.34
25.33
u/l
0.01
357
3209
48
248
2.07
4.80
2.8
2.6
63.94
63.59
ml/min/173m2
0.02
20
100
285
2422
1.69
4.74
5.4
3.8
14.79
14.76
pmol/l
0.06
267
2187
40
194
2.19
4.70
1.6
1.4
—
—
—
0
0
60
339
1.91
4.67
6.9
7.0
12.24
12.17
kpa
0.02
60
327
60
339
1.91
4.67
6.9
7.0
5.25
5.14
kpa
0.37
60
325
139
999
1.61
4.63
3.7
2.4
52.17
61.90
u/l
1.10
128
926
329
2919
1.89
4.61
6.1
4.6
1.96
2.35
mu/l
0.45
312
2658
108
735
1.65
4.45
2.6
2.2
—
—
—
0
0
40
199
2.13
4.42
3.5
4.5
1.74
1.73
mmol/l
0.01
27
141
17
55
3.19
4.41
1.5
1.5
—
—
—
0
0
59
339
1.87
4.36
6.9
7.0
1.11
1.37
mmol/l
0.24
52
274
327
2925
1.79
4.06
23.0
13.0
80.03
81.15
ml/min/173m2
0.36
277
2413
24
99
2.52
4.05
5.4
2.0
296.23
305.10
ug/l
0.02
24
92
82
535
1.68
3.93
1.3
1.3
15.45
31.42
iu/ml
1.90
25
169
27
120
2.34
3.90
3.2
2.1
3.00
2.96
g/l
0.06
27
109
8
11
7.40
3.87
2.3
1.0
7.63
9.71
ug/l
—
8
11
60
361
1.78
3.83
3.5
3.0
13.09
9.34
umol/l
0.28
52
315
23
99
2.41
3.57
1.3
1.6
—
203.33
—
0
6
65
409
1.71
3.55
10.4
4.8
1.08
1.08
mmol/l
0.05
60
379
12
31
3.96
3.52
1.8
1.4
—
—
—
0
0
45
255
1.87
3.48
2.2
2.5
8.14
4.88
ug/l
0.47
37
225
371
3501
2.76
3.47
38.7
20.5
255.07
249.55
e9/l
0.77
363
3413
371
3502
2.75
3.45
38.4
20.5
39.27
40.08
%
1.88
353
3279
19
76
2.58
3.43
2.6
1.5
—
—
—
0
0
371
3503
2.75
3.43
38.7
20.5
4.39
4.48
e12/l
2.51
363
3406
7
10
7.11
3.37
1.0
1.0
1708.29
1332.60
miu/ml
—
7
10
16
59
2.79
3.36
2.4
1.3
—
—
—
0
0
320
2887
1.65
3.33
8.2
5.7
42.01
39.85
mmol/mol
2.66
305
2687
86
592
1.58
3.30
2.4
2.7
2.43
2.46
mmol/l
1.15
76
520
137
1044
1.49
3.29
3.2
3.5
31.02
31.46
u/l
0.05
131
1003
26
123
2.19
3.28
5.2
4.8
1.45
1.57
%
0.43
26
114
23
104
2.29
3.22
3.2
2.0
38.09
37.98
g/l
0.03
23
93
34
181
1.96
3.17
2.5
3.5
4.26
4.55
pmol/l
0.79
27
159
7
12
5.92
3.03
1.4
1.1
—
—
—
0
0
82
575
1.54
2.89
1.7
1.6
—
—
—
0
0
47
287
1.73
2.86
6.9
7.4
120.85
120.13
g/l
0.09
47
280
240
2068
1.43
2.85
4.2
3.1
57.62
48.18
u/l
1.05
229
1941
13
47
2.83
2.84
1.7
1.7
—
—
—
0
0
9
23
3.98
2.79
1.4
1.4
—
—
—
0
0
12
40
3.06
2.72
1.5
1.8
—
—
—
0
0
35
199
1.83
2.71
6.9
6.3
24.83
24.70
mmol/l
0.08
35
189
14
55
2.60
2.64
1.6
1.6
—
—
—
0
0
9
25
3.66
2.59
4.2
3.1
—
—
—
0
0
12
44
2.78
2.57
1.4
1.7
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
5
7
7.22
2.55
1.8
1.0
101.00
133.14
%
—
5
7
83
599
1.49
2.54
5.2
3.7
23.91
237.12
ng/l
3.39
59
461
19
90
2.17
2.43
1.3
1.1
—
—
—
0
0
74
527
1.50
2.41
1.3
1.3
1.55
11.01
u/ml
3.05
20
204
148
1198
1.38
2.41
5.3
3.9
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
8
6.31
2.38
2.0
4.4
163.40
142.75
%
—
5
8
47
303
1.63
2.36
2.3
2.6
31.05
29.62
u/l
0.10
41
255
20
98
2.10
2.36
1.8
1.2
—
—
—
0
0
17
78
2.23
2.34
1.4
1.2
—
31.24
—
0
10
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
17
78
2.23
2.34
3.3
2.4
0.42
0.33
u/ml
—
10
41
15
65
2.36
2.34
1.5
1.4
—
—
—
0
0
15
65
2.36
2.34
1.5
1.4
—
—
—
0
0
20
99
2.08
2.30
1.7
1.5
—
—
—
0
0
18
86
2.15
2.26
1.4
1.3
—
—
—
0
0
334
3118
1.55
2.19
5.5
4.9
2.63
2.75
mmol/l
1.56
312
2871
326
3030
1.50
2.16
5.5
4.5
6.14
5.95
mmol/l
1.60
314
2766
91
689
1.42
2.16
5.0
4.0
1.02
1.02
kg/l
0.02
16
99
54
368
1.54
2.16
12.5
7.5
—
—
—
0
0
9
30
3.05
2.16
1.0
1.1
—
—
—
0
0
18
89
2.07
2.09
1.5
1.3
187.90
309.80
ug/g
—
10
48
10
37
2.75
2.08
2.5
1.3
—
—
—
0
0
16
76
2.15
2.05
1.1
1.2
—
—
—
0
0
6
15
4.05
2.04
1.5
5.5
105.33
89.20
%
—
6
15
6
15
4.05
2.04
1.3
2.2
789.33
975.67
u/ml
—
6
15
328
3063
1.49
2.01
5.0
4.4
4.50
4.67
mmol/l
2.05
307
2835
6
17
3.57
1.84
2.8
1.4
—
—
—
0
0
6
17
3.57
1.84
2.8
1.4
—
—
—
0
0
9
35
2.61
1.81
1.9
1.6
—
—
—
0
0
9
35
2.61
1.81
1.9
1.6
—
—
—
0
0
13
60
2.21
1.79
1.4
1.2
224.00
229.52
u/ml
—
6
27
16
81
2.02
1.77
2.0
1.2
—
—
—
0
0
18
96
1.92
1.73
1.3
1.2
—
—
—
0
0
12
55
2.22
1.69
3.2
1.7
—
—
—
0
0
12
55
2.22
1.69
3.2
1.7
—
—
—
0
0
6
19
3.19
1.66
2.8
1.4
—
—
—
0
0
6
19
3.19
1.66
2.8
1.4
—
—
—
0
0
14
69
2.07
1.66
1.4
1.4
—
—
—
0
0
18
98
1.88
1.64
1.3
1.2
—
—
—
0
0
16
84
1.94
1.62
1.1
1.9
—
—
—
0
0
13
63
2.10
1.61
1.4
1.2
—
—
—
0
0
104
842
1.32
1.61
4.8
4.1
0.00
0.00
estimate
-0.00
29
281
8
32
2.53
1.60
7.0
2.2
—
—
—
0
0
313
2931
1.37
1.59
4.6
4.0
1.37
1.27
mmol/l
1.73
291
2685
7
26
2.72
1.58
1.0
1.2
—
—
—
0
0
6
20
3.03
1.58
1.0
1.1
—
—
—
0
0
10
44
2.31
1.56
1.2
1.3
—
—
—
0
0
323
3043
1.39
1.55
4.9
4.4
1.42
1.49
mmol/l
2.29
300
2798
8
33
2.45
1.54
1.3
1.2
—
—
—
0
0
17
93
1.87
1.54
2.0
2.3
1452.00
2481.27
u/l
—
5
34
15
79
1.94
1.51
2.8
1.8
—
—
—
0
0
15
80
1.91
1.46
2.8
1.8
—
—
—
0
0
27
173
1.60
1.44
1.7
1.9
—
—
—
0
0
22
134
1.68
1.42
1.5
1.9
—
—
—
0
0
47
346
1.41
1.33
1.6
1.8
1.42
1.43
%
0.03
40
307
28
186
1.55
1.30
2.3
1.7
—
—
—
0
0
34
237
1.48
1.28
7.5
3.5
147.32
75.21
ng/l
1.20
28
209
6
25
2.42
1.25
1.2
1.0
—
—
—
0
0
10
49
2.07
1.23
1.0
1.1
—
—
—
0
0
31
216
1.47
1.18
2.6
2.5
—
15.35
—
0
13
28
192
1.49
1.15
1.4
1.3
—
34.01
—
0
11
44
331
1.37
1.12
2.5
2.1
—
—
—
0
0
100
843
1.25
1.12
1.8
1.6
1.50
1.37
mmol/l
0.77
88
716
18
112
1.64
1.11
1.6
2.0
—
—
—
0
0
7
31
2.28
1.11
1.0
1.1
—
—
—
0
0
12
66
1.84
1.10
3.4
1.8
—
—
—
0
0
11
59
1.89
1.08
2.9
1.9
—
—
—
0
0
13
75
1.76
1.04
2.5
2.6
439.57
109.02
ug/min
—
7
44
216
1984
1.20
1.01
3.2
3.1
—
—
—
0
0
7
36
1.96
0.97
1.1
1.8
—
—
—
0
0
6
27
2.24
0.94
1.8
1.8
—
—
—
0
0
6
27
2.24
0.94
1.2
1.3
—
—
—
0
0
11
63
1.77
0.91
1.2
1.8
—
—
—
0
0
6
29
2.09
0.89
1.0
1.1
—
—
—
0
0
8
42
1.92
0.89
3.9
2.8
106.88
105.83
mmol/l
—
8
42
8
47
1.72
0.81
1.4
1.8
—
—
—
0
0
6
33
1.83
0.79
4.3
1.8
—
—
—
0
0
6
33
1.83
0.79
4.3
1.8
—
—
—
0
0
6
33
1.83
0.79
4.3
1.8
—
—
—
0
0
6
34
1.78
0.76
4.3
2.0
—
—
—
0
0
7
38
1.86
0.74
3.9
1.9
—
—
—
0
0
7
41
1.72
0.70
1.3
1.5
—
—
—
0
0
7
42
1.68
0.68
1.3
1.5
—
—
—
0
0
7
42
1.68
0.68
1.3
1.5
—
—
—
0
0
7
42
1.68
0.68
1.3
1.5
—
—
—
0
0
7
42
1.68
0.68
1.3
1.5
—
—
—
0
0
7
42
1.68
0.68
1.3
1.5
—
—
—
0
0
38
304
1.28
0.68
2.2
1.9
—
—
—
0
0
5
29
1.73
0.64
1.4
1.6
—
—
—
0
0
10
64
1.58
0.59
4.4
3.2
26.70
36.02
u/ml
—
10
64
8
53
1.52
0.58
1.3
1.1
—
—
—
0
0
8
54
1.49
0.57
1.1
1.7
174.00
214.70
pmol/l
—
8
47
6
37
1.63
0.56
1.0
1.1
—
—
—
0
0
6
37
1.63
0.56
2.0
1.9
—
—
—
0
0
13
91
1.44
0.53
1.2
1.5
—
252.84
—
0
41
6
39
1.55
0.53
1.0
1.1
—
—
—
0
0
17
129
1.33
0.46
4.0
1.9
—
—
—
0
0
16
121
1.34
0.45
2.9
1.7
—
—
—
0
0
5
34
1.48
0.40
4.2
3.1
24.80
63.24
u/ml
—
5
34
21
169
1.26
0.39
1.4
1.3
—
—
—
0
0
13
98
1.34
0.38
1.6
1.4
—
—
—
0
0
9
70
1.29
0.37
1.7
2.3
122.67
125.11
g/l
—
9
51
6
41
1.47
0.36
3.2
3.0
10.77
10.26
umol/l
—
6
28
22
184
1.21
0.31
6.9
2.9
39.61
48.83
u/ml
0.15
22
178
90
836
1.10
0.31
4.5
5.1
1.85
2.89
ug/l
1.28
84
748
7
53
1.33
0.31
2.7
3.4
64.86
58.51
%
—
7
53
34
387
0.87
0.30
5.7
4.5
29.52
32.07
%
0.61
27
261
7
55
1.28
0.30
1.0
1.3
—
—
—
0
0
10
130
0.76
0.30
2.0
1.5
—
—
—
0
0
38
337
1.14
0.28
3.3
4.1
13.61
32.75
ug/l
0.39
31
281
8
67
1.20
0.26
2.1
1.4
—
—
—
0
0
8
67
1.20
0.26
2.1
1.4
—
—
—
0
0
8
67
1.20
0.26
2.1
1.4
—
—
—
0
0
9
72
1.26
0.26
1.2
1.3
3.68
3.93
mmol/l
—
9
66
9
72
1.26
0.26
2.1
1.4
—
—
—
0
0
9
77
1.17
0.24
1.3
1.3
—
—
—
0
0
6
83
0.72
0.24
1.5
1.3
—
—
—
0
0
12
97
1.24
0.23
2.1
1.5
—
—
—
0
0
5
39
1.29
0.23
1.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
14.48
—
0
5
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
111.90
—
0
13
12
99
1.22
0.20
3.2
2.4
—
—
—
0
0
70
668
1.06
0.13
4.8
4.5
23.07
21.39
%
0.37
29
318
5
46
1.09
0.09
1.6
1.3
—
—
—
0
0
50
478
1.05
0.09
2.7
3.1
0.81
0.79
ug/l
0.03
37
305
25
267
0.93
0.08
1.3
1.7
—
—
—
0
0
6
58
1.04
0.08
1.0
1.1
—
—
—
0
0
12
108
1.11
0.07
1.5
1.6
—
—
—
0
0
18
172
1.05
0.02
1.0
1.0
—
—
—
0
0
22
214
1.03
0.00
1.2
1.2
26.40
127.31
iu/ml
—
8
86
51
509
1.00
0.00
1.8
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.1
—
3.70
u/ml
—
0
32
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
2.6
3.0
4.00
79.43
u/ml
—
5
51
Mortality – FinRegistry
↥Association
Association between endpoint L12_OTHERBULL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERBULL | 1.902 [1.48, 2.45] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.074 |
During the follow-up period (1.1.1998 — 31.12.2019), 276 out of 1248 females with L12_OTHERBULL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_OTHERBULL | 2.2 [1.6, 3.02] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 245 out of 961 males with L12_OTHERBULL died.
Mortality risk
Mortality risk for people of age
years, who have L12_OTHERBULL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.175% | 0.288% |
| 5 | 1.006% | 2.259% |
| 10 | 2.608% | 6.262% |
| 15 | 4.971% | 11.153% |
| 20 | 8.711% | 18.21% |
Relationships between endpoints
↥Index endpoint: L12_OTHERBULL – Other and unspecified bullous disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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