Severe bullous disorders, KELA reimbursement

L12_PEMPHIKELA

vesiculobullous skin disease: Skin diseases characterized by local or general distributions of vesicles and bullae (i.e. blisters). Both vesicles and bullae are fluid-filled lesions, distinguished by size (vesicles being less than 5–10 mm and bullae being larger than 5–10 mm). Vesiculobullous diseases are classified according to the site and mode of blister formation. Lesions can appear spontaneously or be precipitated by infection, trauma, or sunlight. Etiologies include immunologic and genetic factors. In the case of vesiculobullous diseases which are also immune disorders, the term immunobullous is sometimes used. (From Scientific American Medicine, 1990, and Wikipedia)

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	519972
1. Apply sex-specific rule None	519972
2. Check conditions None	519972
3. Check pre-conditions, main-only, mode, registry filters Registry filters: KELA reimbursements: KELA codes — 135 1 out of 7 registries used, show all original rules.	73
4. Check minimum number of events None	73
5. Include endpoints None	73
6. Filter based on genotype QC (FinnGen only)	70

Control definitions (FinnGen only)

Control exclude: L12_BULLOUS

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2

NAME	L12_PEMPHIKELA
CONTROL_EXCLUDE	L12_BULLOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	135
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Severe bullous disorders, KELA reimbursement based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	753	435	305
Only index persons	495	299	196
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	70.06	70.07	70.21
Only index persons	68.20	68.53	67.69

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	70	34	36
Unadjusted period prevalence (%)	0.01	0.01	0.02
Median age at first event (years)	64.30	60.85	67.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
73: Matched controls
730

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

135

Kela drug reimbursment

Pemphigus

+∞

104.9

L12.0

ICD-10 Finland

Bullous pemphigoid

+∞

61.3

L04AX01

ATC

azathioprine; systemic

141.5

45.2

D07AD01

ATC

clobetasol; topical

14.1

30.2

H02AB06

ATC

prednisolone; systemic

42.3

25.0

259

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

12.7

24.6

D07AC01

ATC

betamethasone; topical

9.3

18.8

171

M05BA04

ATC

alendronic acid; oral

9.7

16.3

E0000UV, ,

ATC

6.8

14.2

186

J04BA02

ATC

dapsone; oral

+∞

12.9

L12.9

ICD-10 Finland

Pemphigoid, unspecified

+∞

12.9

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

5.9

12.2

197

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

6.7

11.4

L12.1

ICD-10 Finland

Cicatricial pemphigoid

+∞

10.7

L30.9

ICD-10 Finland

Dermatitis, unspecified

5.5

9.7

L12.8

ICD-10 Finland

Other pemphigoid

+∞

9.6

L10.0

ICD-10 Finland

Pemphigus vulgaris

+∞

9.6

L04AX03

ATC

methotrexate; systemic

5.9

8.9

D07AC13

ATC

mometasone; topical

4.4

8.5

111

E000001, ,

ATC

4.6

8.2

NK6QA

NOMESCO Finland

Measurement of bone density from two or more locations with X-ray

7.6

6.6

L10.2

ICD-10 Finland

Pemphigus foliaceus

+∞

6.3

D07AB08

ATC

desonide; topical

4.7

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42870298) TPMT gene c.238G>C+460G>A+719A>G [Identifier] in Blood or Tissue by Molecular genetics method Narrative

+∞

12.88

1.0

0.0

—

(40760892) CBC W Ordered Manual Differential panel - Blood

244

5.28

10.05

15.3

6.7

—

(3006504) Eosinophils/100 leukocytes in Blood

239

4.19

7.95

14.2

6.0

3.03

2.56

0.80

224

(3019069) Monocytes/100 leukocytes in Blood

243

4.09

7.67

14.6

6.4

9.13

8.49

0.75

229

(3022096) Basophils/100 leukocytes in Blood

232

3.88

7.30

14.5

6.0

0.77

0.62

1.29

218

(3013707) Erythrocyte sedimentation rate by Westergren method

420

2.63

2.99

4.5

4.4

14.35

14.62

mm/h

0.04

377

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

148

2.31

2.79

2.0

1.7

295.95

468.71

pmol/l

3.83

128

(3000494) Fungus identified in Specimen by Culture

2.56

2.37

1.2

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

3.16

2.16

5.6

5.8

—

(40768443) Skin Pathology biopsy report

3.75

2.11

1.3

1.1

—

(3039000) Anion gap in Blood

5.27

2.10

6.8

5.2

13.00

10.20

mmol/l

—

(3018572) Chloride [Moles/volume] in Blood

5.27

2.10

6.8

5.2

106.00

104.40

mmol/l

—

(3023368) Bacteria identified in Blood by Culture

186

1.93

1.88

3.6

4.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.37

1.72

2.5

1.8

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

264

1.81

1.69

2.0

2.4

—

(3015736) pH of Urine

228

1.82

1.67

3.5

4.0

—

5.63

—

(3022217) INR in Platelet poor plasma by Coagulation assay

313

1.71

1.40

21.6

15.0

1.27

1.36

inr

0.24

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

224

1.67

1.27

4.3

4.6

—

(3037467) Urinalysis macro (dipstick) panel - Urine

389

1.68

1.26

4.3

4.6

—

(3041096) Erythrocytes [Presence] in Urine by Automated

163

1.70

1.23

3.6

4.2

—

(3029937) Albumin [Presence] in Urine by Test strip

168

1.64

1.09

4.5

4.2

0.00

estimate

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

527

1.78

1.05

6.4

42.39

40.80

mmol/mol

0.45

484

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

540

1.79

1.01

20.5

16.6

26.07

26.19

mg/l

0.01

433

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

311

1.55

1.01

6.9

6.3

1.19

1.21

mmol/l

0.69

266

(40761511) CBC panel - Blood by Automated count

566

1.83

0.95

22.4

15.6

—

(3035350) Ketones [Presence] in Urine by Test strip

287

1.50

0.90

4.4

4.3

0.00

estimate

—

(3002256) Pathology report gross observation

1.87

0.89

1.1

1.3

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

1.82

0.88

4.8

5.5

113.00

119.74

g/l

0.54

(3021601) Nitrite [Presence] in Urine by Test strip

289

1.48

0.87

4.7

5.9

0.00

estimate

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

537

1.66

0.85

4.5

5.1

6.04

6.11

mmol/l

0.13

484

(3019060) Gas panel - Arterial blood

1.79

0.84

4.6

3.5

—

(40761536) Microorganisms panel - Urine sediment

1.79

0.79

3.8

4.6

—

(3009261) Glucose [Presence] in Urine by Test strip

293

1.45

0.79

4.3

0.00

estimate

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

255

1.45

0.78

2.2

2.0

79.37

92.23

pmol/l

0.97

119

(3013512) EKG study

189

0.62

0.77

4.2

4.4

—

(3000991) Gas panel - Venous blood

1.72

0.77

2.6

6.5

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.77

0.76

2.6

3.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

257

1.44

0.74

2.7

2.5

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.83

0.74

1.7

1.4

—

(3022145) Colonoscopy Study observation

1.63

0.73

1.1

1.2

—

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

1.78

0.72

2.7

2.0

209.43

107.60

ng/l

—

(4200892) Spirometry reversibility

1.74

0.71

3.0

1.3

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.74

0.71

1.0

1.3

—

(1761868) Lipid panel - Serum or Plasma

166

1.47

0.70

3.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

513

1.51

0.69

4.5

4.6

2.05

2.02

mu/l

0.06

452

(3012516) Albumin [Mass/volume] in Urine

195

1.43

0.67

3.1

3.2

158.94

49.35

mg/l

0.67

131

(3004588) Protein electrophoresis panel - Serum or Plasma

1.71

0.65

1.4

2.1

—

(3018418) pH of Serum or Plasma

197

1.41

0.63

5.6

4.4

7.41

7.39

—

(3020891) Body temperature

1.71

0.62

2.0

4.4

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

529

1.47

0.60

4.0

5.0

1.53

1.45

mmol/l

0.57

471

(3020564) Creatinine [Moles/volume] in Serum or Plasma

573

1.54

0.59

29.0

19.7

82.55

81.86

umol/l

0.07

573

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.59

0.0

5.2

—

(3009542) Hematocrit [Volume Fraction] of Blood

596

1.60

0.58

36.4

23.9

38.65

39.57

0.47

552

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.68

0.57

2.0

3.0

0.63

0.71

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.68

0.57

1.7

3.0

1.12

1.16

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

512

1.40

0.53

3.6

4.4

1.13

1.26

mmol/l

1.10

455

(3044640) Blood type and Crossmatch panel - Blood

176

1.36

0.50

2.1

2.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.57

0.49

8.6

9.5

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.66

0.44

1.4

2.0

1.07

1.93

g/l

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.41

0.0

3.3

—

108.13

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.41

0.0

3.5

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.41

0.0

3.3

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.41

0.0

3.3

—

3.87

—

(40768800) Prostate Pathology biopsy report

0.00

0.41

0.0

1.2

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

0.41

0.0

1.5

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.41

0.0

1.1

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.41

0.0

2.7

—

3.11

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.41

0.0

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.41

0.0

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.41

0.0

1.1

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

2.5

—

11.66

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.7

—

(3008898) HLA-B27 [Presence]

0.00

0.40

0.0

1.2

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

0.00

0.40

0.0

1.2

—

(3044889) 12 lead EKG panel

417

1.28

0.40

3.8

4.1

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.39

0.0

1.1

—

(3003694) ABO and Rh group [Type] in Blood

122

0.70

0.39

1.2

1.4

—

(3022621) pH of Urine by Test strip

1.42

0.39

3.0

3.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

532

1.33

0.39

4.1

5.0

4.41

4.46

mmol/l

0.11

480

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.43

0.36

1.3

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

213

1.26

0.36

3.3

3.7

48.90

7.53

mg/mmol

0.69

140

(3026008) Bacteria identified in Urine by Culture

201

1.21

0.25

3.9

3.1

—

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

125

0.77

0.25

4.8

2.6

2.54

2.47

mmol/l

—

107

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

106

1.28

0.25

1.5

1.7

—

(3009343) pH of Capillary blood

1.34

0.24

1.8

3.7

—

7.45

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.0

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.21

0.0

1.4

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

3.3

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.8

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.21

0.0

1.3

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.21

0.0

1.3

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.7

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.9

—

(1002224) Polysomnography panel

0.00

0.20

0.0

1.1

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

176

1.19

0.20

5.4

5.1

24.79

22.08

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

206

1.17

0.19

3.3

2.8

2.35

2.34

mmol/l

0.05

176

(40761535) Cells panel - Urine sediment

1.25

0.19

4.1

3.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

129

1.20

0.19

2.8

2.3

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.21

0.18

2.3

2.5

24.14

24.25

u/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.18

0.18

1.9

1.4

—

(3021589) Normoblasts [#/volume] in Blood

246

1.15

0.18

14.1

10.8

0.00

e9/l

0.71

206

(3042936) Bacteria identified in Isolate by Culture

0.77

0.15

2.6

2.1

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

113

1.18

0.14

4.5

3.0

14.92

132.37

ng/l

1.35

(40758558) Short blood count panel - Blood

143

1.15

0.13

8.2

6.4

—

(40768797) Stomach Pathology biopsy report

1.19

0.11

1.1

1.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.07

0.09

1.0

1.6

—

(36304419) Bacteria [Presence] in Urine

174

0.90

0.08

2.2

3.2

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.16

0.08

2.8

5.0

102.90

104.00

mmol/l

—

(40768804) Tissue Pathology biopsy report

206

1.10

0.08

2.0

2.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.11

0.08

1.8

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.06

0.07

1.8

1.7

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

128

1.12

0.07

4.0

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

110

1.11

0.05

2.2

2.6

0.85

0.82

mmol/l

0.46

100

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

231

1.06

0.03

2.6

3.2

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

103

1.08

0.02

1.5

1.3

1.10

1.33

u/ml

—

(3018095) Leukocytes [#/volume] in Urine

223

1.05

0.01

3.1

3.9

182.09

52.60

e6/l

0.63

164

(3002582) Erythrocytes [#/volume] in Urine

202

0.99

0.00

2.8

3.3

17.41

51.78

e6/l

1.07

159

(40764999) Glomerular filtration rate/1.73 sq M.predicted [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)

506

1.03

0.00

22.1

16.1

68.88

75.51

ml/min/173m2

1.22

415

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3021788) Differential panel - Synovial fluid

0.00

-0.00

0.0

1.3

—

(3006571) Polymorphonuclear cells/100 leukocytes in Synovial fluid

0.00

-0.00

0.0

1.6

—

47.60

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.0

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3036535) Thyroglobulin [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

4.8

—

(40763470) Parainfluenza virus 4 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

0.00

-0.00

0.0

1.3

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(40763324) Parainfluenza virus 1 RNA [Presence] in Isolate by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3013727) Leukocytes other/100 leukocytes in Blood

0.00

-0.00

0.0

5.0

—

58.20

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

2.6

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

3.5

—

138.59

—

(3011288) Drugs identified in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3045424) Erythrocytes [Presence] in Urine

0.00

-0.00

0.0

1.1

—

(3045716) Anion gap in Serum or Plasma

0.00

-0.00

0.0

3.6

—

8.80

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3025130) Human papilloma virus identified in Specimen

0.00

-0.00

0.0

2.7

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3042631) Mycobacterium sp identified in Specimen

0.00

-0.00

0.0

4.3

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

13.52

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

-0.00

0.0

1.1

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

0.85

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

2.2

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

-0.00

0.0

1.2

—

275.94

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

-0.00

0.0

1.0

—

(3009595) Pneumocystis jiroveci DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.2

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

-0.00

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

4.2

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.2

—

6.20

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

2.1

—

9.93

—

(3023410) Appearance of Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

0.98

-0.00

1.0

1.6

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

293.80

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.4

—

(3043849) Epstein Barr virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

-0.00

0.0

1.6

—

159.63

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PEMPHIKELA and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_PEMPHIKELA	1.276 [0.98, 1.66]	0.067
Birth year	0.998 [0.99, 1.01]	0.707

During the follow-up period (1.1.1998 — 31.12.2019), 108 out of 247 females with L12_PEMPHIKELA died.

Males

Parameter	HR [95% CI]	p-value
L12_PEMPHIKELA	1.912 [1.27, 2.89]	0.002
Birth year	0.989 [0.98, 1.0]	0.016

During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 176 males with L12_PEMPHIKELA died.

Mortality risk

Mortality risk for people of age

years, who have L12_PEMPHIKELA.

N-year risk	Females	Males
1	0.133%	0.453%
5	0.775%	2.226%
10	2.036%	5.532%
15	4.081%	10.457%
20	7.01%	17.319%

Relationships between endpoints

↥

Index endpoint: L12_PEMPHIKELA – Severe bullous disorders, KELA reimbursement

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Severe bullous disorders, KELA reimbursement

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints