bullous pemphigoid: Bullous pemphigoid (BP) is the most common form of autoimmune bullous dermatosis.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
774 |
4. Check minimum number of eventsNone |
774 |
5. Include endpointsNone |
774 |
6. Filter based on genotype QC (FinnGen only) |
760 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L12
- Name in latin
- Pemphigoides bullosus
Similar endpoints
↥List of similar endpoints to
Bullous pemphigoid
based on the number of shared cases.
Similar with more cases:
- Pemphigoid
- Bullous disorders
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6427 | 3635 | 2742 |
| Only index persons | 5536 | 3158 | 2378 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.10 | 0.08 |
| Only index persons | 0.11 | 0.12 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 78.57 | 79.60 | 77.21 |
| Only index persons | 78.21 | 79.15 | 76.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 760 | 355 | 405 |
| Unadjusted period prevalence (%) | 0.16 | 0.13 | 0.19 |
| Median age at first event (years) | 74.65 | 73.51 | 75.64 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 774
- Matched controls
- 7740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
15.7
307.7
401
497
L12.0
ICD-10 Finland
Bullous pemphigoid
+∞
307.7
774
*
D07AD01
ATC
clobetasol; topical
12.2
280.0
428
714
L30.9
ICD-10 Finland
Dermatitis, unspecified
6.5
143.1
338
820
D07AC01
ATC
betamethasone; topical
6.4
140.2
524
1905
L12.9
ICD-10 Finland
Pemphigoid, unspecified
719.8
127.2
122
*
TQW80
NOMESCO Finland
Local dermatologic skincare
16.3
123.5
110
78
L04AX01
ATC
azathioprine; systemic
12.4
115.4
122
115
E0000UV, ,
ATC
5.2
107.4
523
2214
H02AB06
ATC
prednisolone; systemic
6.0
106.7
605
2885
L04AX03
ATC
methotrexate; systemic
6.3
91.7
180
353
J04BA02
ATC
dapsone; oral
165.3
58.8
61
*
XQ848
NOMESCO Finland
Dermatological photography
8.3
56.6
78
103
L12.8
ICD-10 Finland
Other pemphigoid
+∞
55.9
53
*
L13.9
ICD-10 Finland
Bullous disorder, unspecified
127.5
55.6
59
5
D07AC13
ATC
mometasone; topical
3.2
53.9
326
1420
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
4.0
53.1
183
556
135
Kela drug reimbursment
Pemphigus
+∞
52.7
50
*
L12
ICD-10 Finland
Pemphigoid
189.3
51.6
53
*
ECA20
NOMESCO Finland
Biopsy of gingiva
17.1
46.4
39
24
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.9
45.9
419
2245
D07AB08
ATC
desonide; topical
3.9
45.6
155
463
L29.9
ICD-10 Finland
Pruritus, unspecified
8.1
45.2
63
84
D07BC01
ATC
betamethasone and antiseptics; topical
3.7
44.2
166
530
E000001, ,
ATC
3.1
39.9
220
885
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
37.8
36
*
D07AB02
ATC
hydrocortisone butyrate; topical
2.7
35.8
296
1463
A10BH05
ATC
linagliptin; oral
3.9
31.0
101
289
L04AA06
ATC
mycophenolic acid; systemic
10.1
29.6
34
35
L29.8
ICD-10 Finland
Other pruritus
10.1
29.6
34
35
D02AX
ATC
Other emollients and protectives
6.6
29.5
49
79
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
29.1
193
842
R06AE07
ATC
cetirizine; oral
2.3
27.8
351
2050
D09AB01
ATC
zinc bandage without supplements; topical
6.8
27.5
44
68
A10AB05
ATC
insulin aspart; parenteral
3.4
27.4
110
361
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
4.3
26.1
70
173
A46
ICD-10 Finland
Erysipelas
2.6
25.9
187
847
S97
ICPC
Chronic ulcer skin
3.3
25.2
104
347
L30.3
ICD-10 Finland
Infective dermatitis
5.1
24.0
52
108
S99
ICPC
Skin disease other
6.0
23.9
43
75
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.3
23.6
256
1383
A02BC02
ATC
pantoprazole; systemic
2.3
23.5
577
4300
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
23.2
151
647
T90
ICPC
Diabetes non-insulin dependent
2.2
22.8
253
1376
L30.0
ICD-10 Finland
Nummular dermatitis
4.6
22.8
56
129
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.5
22.4
168
770
J01DB01
ATC
cefalexin; oral
2.6
22.0
646
5117
S18
ICPC
Laceration/cut
2.1
21.9
412
2735
A10AE04
ATC
insulin glargine; parenteral
2.8
21.5
123
492
S29
ICPC
Skin symptom/complaint other
2.4
21.4
190
937
R06AX27
ATC
desloratadine; oral
2.3
21.0
193
966
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.6
20.7
141
616
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
19.6
276
1630
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.2
18.9
52
131
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.9
18.5
96
364
A28
ICPC
Limited function/disability NOS
2.1
18.0
234
1335
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
17.8
238
1370
L13.0
ICD-10 Finland
Dermatitis herpetiformis
+∞
17.8
17
*
S17
ICPC
Abrasion/scratch/blister
5.1
17.7
38
78
103
Kela drug reimbursment
Diabetes, insulin-treated
2.0
17.6
285
1758
H02AB09
ATC
hydrocortisone; systemic
5.5
17.4
34
64
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.1
17.2
77
268
C03CA01
ATC
furosemide; systemic
1.9
17.0
389
2682
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.2
17.0
71
237
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
5.0
17.0
37
77
A10BA02
ATC
metformin; oral
1.9
16.8
290
1820
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
5.5
16.5
32
60
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.8
16.2
87
335
A10AC01
ATC
insulin (human); parenteral
2.6
15.8
99
412
S02
ICPC
Pruritus
3.9
15.8
48
130
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.6
15.3
96
400
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
4.2
15.1
40
98
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
15.0
179
981
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
4.6
14.6
35
79
L30.8
ICD-10 Finland
Other specified dermatitis
4.8
14.6
33
71
L89
ICD-10 Finland
Decubitus ulcer and pressure area
4.3
14.3
37
89
S21
ICPC
Skin texture symptom/complaint
2.2
14.2
132
655
SPAT1229
SPAT
Assessment of need for aid
2.4
13.8
102
459
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
13.6
418
3079
D02AE01
ATC
carbamide; topical
2.8
13.3
68
255
L20.0
ICD-10 Finland
Besnier prurigo
3.5
13.2
46
137
SPAT1262
SPAT
Handing over of treatment supplies
2.0
13.1
172
971
E000003, ,
ATC
3.4
12.9
48
149
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
12.7
259
1683
EKA10
NOMESCO Finland
iopsy of buccal mucosa
4.6
12.7
30
67
SAA03
NOMESCO Finland
Extended examination of mouth
1.8
12.7
257
1669
E000007, ,
ATC
3.2
12.6
51
167
L10.9
ICD-10 Finland
Pemphigus, unspecified
+∞
12.5
12
*
E86
ICD-10 Finland
Volume depletion
3.5
12.5
43
127
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
12.2
300
2054
L13.8
ICD-10 Finland
Other specified bullous disorders
38.2
12.2
15
*
H02AB07
ATC
prednisone; oral
2.1
12.2
139
745
N18.8
ICD-10 Finland
Other chronic renal failure
3.6
11.7
39
113
ZY010
NOMESCO Finland
Hospital outpatient
3.5
11.7
40
118
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.3
11.6
92
426
J01FF01
ATC
clindamycin; systemic
1.8
11.6
221
1403
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
4.6
11.3
27
61
E000002, ,
ATC
2.4
11.3
85
385
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.8
11.2
192
1177
A10BH02
ATC
vildagliptin; oral
3.7
11.2
35
97
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
10.9
168
995
G63.2*E11.4
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic polyneuropathy
5.5
10.9
21
39
SPAT1254
SPAT
Administration of medicine
1.9
10.7
153
884
R60.0
ICD-10 Finland
Localized oedema
2.0
10.5
128
700
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
10.5
547
4514
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.0
10.5
123
664
L12.2
ICD-10 Finland
Chronic bullous disease of childhood
+∞
10.4
10
*
R06AE09
ATC
levocetirizine; oral
2.1
10.3
100
503
A04
ICPC
Weakness/tiredness general
1.9
10.2
141
806
I83.0
ICD-10 Finland
Varicose veins of lower extremities with ulcer
3.4
10.1
37
114
J01CF05
ATC
flucloxacillin; systemic
2.6
10.1
59
237
L28.1
ICD-10 Finland
Prurigo nodularis
10.2
10.1
19
19
XQ802
NOMESCO Finland
Epicutan test
3.6
10.0
33
95
SPAT1172
SPAT
Guidance concerning hydration
3.4
10.0
35
105
L40.0
ICD-10 Finland
Psoriasis vulgaris
3.2
9.8
39
127
RS222, ,
NOMESCO Finland
5.1
9.6
20
40
D07AA02
ATC
hydrocortisone; topical
2.0
9.4
108
577
L50.9
ICD-10 Finland
Urticaria, unspecified
3.6
9.4
31
89
L10.2
ICD-10 Finland
Pemphigus foliaceus
+∞
9.4
9
*
L28
ICPC
Limited function/disability (L)
1.7
9.3
188
1202
E11
ICD-10 Finland
Type 2 diabetes mellitus
1.8
9.0
147
882
R53
ICD-10 Finland
Malaise and fatigue
1.7
9.0
213
1422
M05BA04
ATC
alendronic acid; oral
2.0
9.0
105
565
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
9.0
263
1856
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
8.9
139
824
E000006, ,
ATC
2.3
8.6
63
282
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
3.4
8.6
30
90
SPAT1216
SPAT
Assessment of functional ability
1.7
8.5
169
1073
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.9
8.4
119
682
L10.0
ICD-10 Finland
Pemphigus vulgaris
91.0
8.4
9
*
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
7.7
8.2
18
24
D01AE15
ATC
terbinafine; topical
2.2
8.2
68
321
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
8.2
178
1159
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.4
8.2
55
237
N18.0
ICD-10 Finland
End-stage renal disease
4.6
8.2
19
42
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.8
8.1
138
837
AA1AD
NOMESCO Finland
CT of head and brain
1.6
8.1
257
1838
S76
ICPC
Skin infection other
2.5
8.1
49
201
SPAT1263
SPAT
Sampling
1.6
8.1
320
2411
A10AE05
ATC
insulin detemir; parenteral
2.4
8.0
53
226
N02BE01
ATC
paracetamol; systemic, rectal
1.9
7.9
670
6010
L03.9
ICD-10 Finland
Cellulitis, unspecified
4.0
7.9
22
56
J01MA02
ATC
ciprofloxacin; systemic
1.5
7.9
324
2456
C07AB07
ATC
bisoprolol; oral
1.5
7.9
447
3636
XQ845
NOMESCO Finland
Dermatoscopy
3.9
7.8
23
61
SBA00
NOMESCO Finland
Microbiological examinations
3.7
7.8
24
66
SPAT1234
SPAT
Support of social functional capacity
2.2
7.7
62
289
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.0
7.6
33
113
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
3.4
7.6
27
82
A10BH01
ATC
sitagliptin; oral
1.9
7.5
96
533
NHQ40
NOMESCO Finland
Amputation of toe
3.5
7.4
25
73
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
2.9
7.4
35
126
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.7
7.4
39
149
K12.10
ICD-10 Finland
Stomatitis NOS
13.5
7.4
12
9
C08CA01
ATC
amlodipine; oral
1.5
7.4
346
2688
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.2
7.3
61
288
SPAT1310
SPAT
Counselling related to known health issue
1.6
7.3
232
1653
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
7.3
242
1744
B86
ICD-10 Finland
Scabies
5.9
7.3
19
33
A98
ICPC
Health maint/preventive medicine
1.9
7.2
682
6190
C03AA03
ATC
hydrochlorothiazide; oral
1.9
7.1
99
564
SPAT1153
SPAT
Removal of sutures
1.5
7.1
254
1858
205
Kela drug reimbursment
Chronic hypertension
1.5
7.1
279
2085
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
7.0
98
560
D07CC01
ATC
betamethasone and antibiotics; topical
1.9
7.0
96
545
F03
ICD-10 Finland
Unspecified dementia
2.1
7.0
63
308
A07AA02
ATC
nystatin; oral
2.2
6.7
58
279
XQ800
NOMESCO Finland
Prick test
2.4
6.7
44
188
E87.5
ICD-10 Finland
Hyperkalaemia
3.1
6.7
27
89
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
1.8
6.6
103
608
SPAT1301
SPAT
No procedures
1.5
6.5
256
1903
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
2.9
6.5
29
101
K13.78
ICD-10 Finland
Other change in the oral mucosa
3.6
6.5
21
60
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
2.5
6.5
40
166
L51.19
ICD-10 Finland
Other bullous erythema multiforme
70.4
6.4
7
*
A10AE06
ATC
insulin degludec; parenteral
2.9
6.4
29
102
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
2.9
6.4
29
102
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
14.4
6.4
10
7
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
1.8
6.4
97
568
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.6
6.4
161
1084
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.6
6.3
148
976
F01.9
ICD-10 Finland
Vascular dementia, unspecified
3.0
6.3
27
92
SPAT1167
SPAT
Insertion of urinary catheter
2.4
6.3
41
174
D07XC01
ATC
betamethasone; topical
1.8
6.3
97
570
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.7
6.3
113
695
4047, ,
NOMESCO Finland
+∞
6.3
6
*
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.5
6.3
263
1981
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
26.9
6.2
8
*
Z2221
NOMESCO Finland
Medical doctor
1.5
6.2
204
1457
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
2.5
6.2
39
163
I50.9
ICD-10 Finland
Heart failure, unspecified
1.6
6.2
179
1243
TQW99
NOMESCO Finland
Other minor procedure on skin
2.2
6.2
53
254
L43.9
ICD-10 Finland
Lichen planus, unspecified
3.4
6.2
22
67
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.1
6.2
59
295
A10BB12
ATC
glimepiride; oral
1.9
6.1
82
462
J45
ICD-10 Finland
Asthma
1.9
6.1
72
389
D64.9
ICD-10 Finland
Anaemia, unspecified
1.7
6.1
112
694
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
6.1
121
766
J01AA07
ATC
tetracycline; systemic
1.8
6.0
90
524
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
297
37
129.63
307.65
1.8
1.1
48.00
58.33
titre
—
20
6
181
532
4.14
55.12
2.7
1.9
338.20
381.12
nmol/l
2.05
163
477
498
2789
3.20
52.68
10.5
5.4
3.25
2.82
%
2.82
477
2582
119
261
5.21
52.30
1.4
1.2
519.95
182.34
u/ml
3.48
112
236
503
2850
3.18
51.80
10.8
5.6
23.54
25.66
%
4.25
481
2642
495
2807
3.12
50.36
10.3
5.4
60.71
59.00
%
2.55
476
2610
560
3486
3.19
46.73
11.4
8.5
4.66
4.31
e9/l
2.69
520
3041
51
6
90.94
46.45
1.1
1.0
—
—
—
0
0
446
3027
2.12
22.62
5.1
4.6
33.36
34.58
g/l
4.29
404
2794
313
1863
2.14
22.43
2.6
2.2
3.10
3.20
mg/l
0.20
270
1564
479
3436
2.03
19.74
7.1
6.7
1.21
1.21
mmol/l
0.71
403
2888
30
44
7.05
19.64
1.3
1.4
—
—
—
0
0
204
1101
2.16
18.18
1.3
1.2
0.96
1.30
u/ml
0.66
57
252
139
650
2.39
17.41
1.5
3.0
65.78
65.86
g/l
0.04
129
577
385
2654
1.90
16.78
14.5
10.1
0.00
0.00
e9/l
0.77
323
2166
600
4803
2.11
16.65
8.7
7.5
83.41
81.47
u/l
0.25
572
4456
462
3388
1.90
16.52
5.9
6.0
12.51
12.18
umol/l
0.13
432
3194
509
3866
1.92
16.18
5.3
4.9
7.49
6.85
mmol/l
5.28
483
3644
172
912
2.14
15.80
3.0
2.4
1.85
1.80
%
0.31
156
803
569
4508
1.99
15.68
4.8
4.2
16.95
14.90
mm/h
2.00
527
4072
365
2524
1.84
15.30
2.6
2.2
79.96
78.88
nmol/l
0.27
325
2173
432
3152
1.84
15.15
6.5
5.9
1.21
1.21
mmol/l
0.21
388
2837
408
2937
1.82
14.84
2.4
2.2
97.11
93.47
pmol/l
0.73
221
1499
201
1154
2.00
14.79
3.0
2.5
11.32
11.91
umol/l
0.67
190
1063
25
19
13.55
14.77
1.4
1.0
8.78
9.67
ug/l
0.37
25
19
363
2529
1.82
14.65
3.4
2.8
135.62
152.09
ug/l
0.68
327
2266
279
1805
1.85
14.23
1.7
1.6
18.47
20.62
nmol/l
1.57
236
1508
132
682
2.13
12.77
3.3
2.6
72.53
67.77
e9/l
0.77
107
537
535
4302
1.79
12.26
6.4
5.3
4564.90
3063.89
e6/l
—
10
85
674
5849
2.18
12.12
26.3
17.8
25.91
27.04
mg/l
0.45
594
4832
171
1001
1.91
11.58
3.1
2.6
20.82
21.74
%
0.36
143
851
243
1586
1.78
11.58
2.0
1.8
1275.33
1212.25
nmol/l
0.42
180
1180
167
983
1.89
11.08
1.5
1.5
3.08
2.67
g/l
1.35
105
552
448
3482
1.68
11.05
21.0
20.1
1.38
1.37
inr
0.08
117
991
120
635
2.05
10.82
6.0
6.5
12.13
11.34
mmol/l
0.51
112
598
175
1059
1.84
10.60
3.0
2.5
2.25
2.25
g/l
0.08
164
970
637
5499
1.89
10.42
7.9
6.5
43.66
41.03
mmol/mol
6.99
592
4971
157
926
1.87
10.29
5.7
5.0
1.05
1.03
mmol/l
0.27
136
850
137
775
1.93
10.19
4.8
3.8
—
—
—
0
0
119
645
2.00
10.01
2.0
2.1
0.20
0.20
g/l
0.19
106
600
284
2013
1.65
9.65
3.4
3.1
6.78
7.00
mmol/l
0.40
235
1646
59
243
2.55
9.60
1.5
2.6
38.08
36.68
g/l
1.03
54
206
66
287
2.42
9.58
1.4
2.7
9.99
10.58
g/l
0.66
61
249
327
2407
1.62
9.51
3.4
3.3
2164.10
1925.59
ng/l
0.32
283
2104
126
710
1.93
9.45
2.4
2.7
9.27
9.61
umol/l
0.04
110
618
293
2109
1.63
9.28
4.1
3.7
18.55
8.79
mg/mmol
0.86
207
1346
28
76
3.78
9.23
1.6
1.4
—
—
—
0
0
687
6149
2.04
9.15
30.7
21.4
138.79
139.52
mmol/l
7.69
672
5962
687
6162
2.02
8.89
30.8
21.5
4.02
4.01
mmol/l
0.71
671
5971
683
6119
1.99
8.79
17.2
11.0
24.01
24.08
u/l
0.03
663
5852
67
305
2.31
8.78
1.4
2.6
3.77
3.52
g/l
0.93
62
269
339
2554
1.58
8.73
4.0
3.4
—
—
—
0
0
67
306
2.30
8.71
1.4
2.6
7.21
7.56
g/l
1.13
62
269
67
306
2.30
8.71
1.4
2.6
—
—
—
0
0
20
29
7.05
8.58
1.0
1.3
—
—
—
0
0
63
282
2.34
8.58
1.4
2.7
2.95
3.09
g/l
0.74
58
245
59
260
2.37
8.32
1.5
3.0
0.36
1.30
g/l
2.01
54
220
360
2773
1.56
8.28
4.9
4.3
184.10
56.17
ng/l
0.46
303
2161
612
5337
1.70
8.20
5.2
4.7
2.04
2.25
mu/l
0.42
563
4726
520
4357
1.59
8.18
4.1
3.8
15.27
15.12
pmol/l
0.67
472
3832
137
828
1.80
8.18
4.2
3.7
231.90
256.14
u/l
1.08
127
771
192
1287
1.65
7.86
1.9
1.8
—
—
—
0
0
641
5685
1.74
7.78
5.5
5.0
6.32
6.10
mmol/l
2.85
586
5033
111
639
1.86
7.74
4.2
6.4
1.57
1.43
mmol/l
0.77
105
623
693
6298
1.96
7.67
40.1
26.0
246.12
239.14
e9/l
1.75
678
6100
693
6298
1.96
7.67
39.8
26.1
38.59
39.08
%
1.44
628
5785
693
6299
1.96
7.66
40.1
26.0
4.24
4.36
e12/l
8.38
677
6072
693
6300
1.96
7.64
40.3
26.2
127.76
131.81
g/l
9.81
681
6164
104
589
1.88
7.63
2.8
2.8
4.41
4.38
kpa
0.06
97
565
119
706
1.81
7.53
3.4
3.5
1.69
2.10
mmol/l
0.49
102
571
141
885
1.73
7.34
4.5
6.6
1.29
1.41
mmol/l
0.14
96
698
119
713
1.79
7.28
3.4
3.5
5.96
5.81
kpa
0.71
113
687
310
2360
1.52
7.24
3.1
3.4
2.35
2.35
mmol/l
0.09
262
2030
273
2023
1.54
7.22
3.0
2.4
60.10
99.41
u/l
0.49
244
1857
139
886
1.69
6.82
4.6
6.5
5.03
5.09
kpa
0.29
124
845
139
887
1.69
6.79
4.6
6.5
11.98
11.59
kpa
0.27
124
846
417
3418
1.48
6.57
3.8
3.1
67.40
54.89
u/l
1.26
378
3107
219
1575
1.54
6.52
2.0
1.8
445.34
4527845.47
pmol/l
0.50
177
1259
245
1809
1.52
6.45
2.8
3.1
35.42
35.14
u/l
0.02
226
1710
640
5753
1.65
6.43
5.2
5.3
2.42
2.55
mmol/l
3.27
580
5134
163
1109
1.60
6.14
1.8
1.9
29.63
29.99
s
0.32
158
1072
161
1093
1.60
6.12
2.7
3.0
0.81
0.81
mmol/l
0.21
139
1006
560
4910
1.51
6.01
32.8
21.0
15.29
15.42
%
0.21
553
4816
68
362
1.96
6.00
1.4
2.0
1.57
1.57
g/l
0.01
59
319
374
3038
1.45
5.95
4.7
4.3
0.00
0.00
estimate
0.50
78
628
64
336
1.99
5.87
4.5
3.8
23.59
24.02
mmol/l
0.37
59
328
346
2789
1.44
5.65
2.3
2.5
—
—
—
0
0
308
2434
1.44
5.58
4.8
4.1
197.74
123.81
e6/l
0.55
231
1827
271
2091
1.46
5.58
2.5
2.1
199.95
246.10
u/l
0.40
255
1951
370
3029
1.42
5.49
6.3
5.8
0.00
0.00
estimate
-0.00
72
572
374
3068
1.42
5.49
4.7
4.3
0.00
0.00
estimate
-0.00
66
561
182
1306
1.51
5.35
1.5
1.7
1.31
1.45
mg/l
0.39
141
1035
136
915
1.59
5.33
1.9
1.8
—
—
—
0
0
76
437
1.82
5.32
4.5
4.0
1.91
2.16
mmol/l
0.22
53
328
52
263
2.05
5.30
1.9
2.1
396.06
599.42
ug/l
0.40
47
248
276
2156
1.44
5.25
4.3
3.5
396.06
116.22
e6/l
0.40
221
1713
136
920
1.58
5.20
1.9
1.8
—
—
—
0
0
36
158
2.34
5.19
3.3
2.0
125.26
126.99
g/l
0.20
31
117
617
5581
1.52
5.16
4.6
4.7
4.35
4.43
mmol/l
1.02
556
5012
76
442
1.80
5.13
1.6
1.5
—
—
—
0
0
79
468
1.77
5.01
4.5
4.0
5.33
5.18
kpa
0.73
74
453
89
552
1.69
4.80
4.1
3.9
135.12
92.99
ng/l
1.81
74
477
27
109
2.53
4.67
3.5
3.0
62.74
61.20
%
0.27
27
109
9
11
8.26
4.57
2.2
2.5
50255.56
33336.82
ug/l
—
9
11
251
1970
1.41
4.52
4.1
3.4
0.53
0.58
e6/l
0.18
201
1545
26
105
2.53
4.50
3.3
2.6
5.35
4.64
e9/l
0.66
26
105
186
1384
1.45
4.49
5.6
4.3
223.55
259.17
ng/l
0.14
166
1203
607
5520
1.46
4.49
4.5
4.6
1.44
1.45
mmol/l
0.12
544
4911
24
94
2.60
4.42
1.2
1.3
—
—
—
0
0
598
5443
1.43
4.22
25.1
16.9
67.99
72.01
ml/min/173m2
4.35
523
4525
206
1586
1.41
4.09
4.4
4.0
84.42
83.75
%
0.14
200
1550
29
130
2.28
4.04
1.3
1.2
12.64
2.46
u/ml
—
5
21
104
708
1.54
3.86
2.5
2.6
5.54
6.05
ug/l
0.14
81
611
28
127
2.25
3.81
1.4
1.2
13.72
2.99
u/ml
—
5
16
72
451
1.66
3.77
1.4
1.5
1.65
1.59
%
0.17
54
363
77
493
1.62
3.71
1.7
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
48
269
1.84
3.70
2.4
2.5
0.37
0.36
u/ml
0.10
28
155
25
110
2.32
3.65
5.8
3.3
0.53
1.77
%
1.85
19
96
187
1444
1.39
3.60
3.5
3.1
2.48
2.46
mmol/l
1.23
162
1265
158
1204
1.39
3.27
3.0
3.0
1.46
1.07
e6/l
0.63
89
725
151
1142
1.40
3.27
3.3
3.3
3.50
2.06
e6/l
0.83
84
668
39
214
1.87
3.24
1.8
1.7
—
198.18
—
0
11
197
1560
1.35
3.21
3.5
2.7
6.11
4.92
e6/l
0.61
183
1407
73
479
1.58
3.20
3.0
3.1
119.89
125.22
g/l
1.53
73
466
579
5325
1.35
3.20
4.1
4.2
1.31
1.25
mmol/l
1.13
513
4687
55
336
1.69
3.19
2.5
1.8
0.87
2.56
ug/l
1.05
46
288
62
391
1.64
3.19
4.7
8.7
24.29
24.70
mmol/l
0.58
53
375
209
1675
1.34
3.14
3.4
2.8
4016.32
9145.47
umol/l
1.06
177
1407
17
68
2.53
3.06
9.6
2.6
56.36
55.04
%
0.08
11
57
82
560
1.52
3.02
1.8
1.6
—
—
—
0
0
19
83
2.32
2.86
1.5
1.5
81.29
67.15
%
1.31
14
60
337
2914
1.28
2.83
3.0
2.7
—
—
—
0
0
24
117
2.08
2.80
1.3
1.2
—
—
—
0
0
5
6
8.38
2.75
1.6
1.0
—
—
—
0
0
44
265
1.70
2.72
1.3
3.8
41.37
85.36
mg/l
1.00
34
211
44
267
1.69
2.65
1.3
3.8
26.23
52.63
mg/l
1.45
34
216
48
301
1.63
2.57
1.7
1.8
—
—
—
0
0
59
390
1.56
2.54
3.5
3.2
25.73
25.15
mmol/l
0.64
59
377
16
72
2.25
2.29
1.4
1.3
113.53
101.92
u/ml
—
6
12
29
164
1.80
2.26
1.6
1.6
—
—
—
0
0
69
485
1.46
2.25
6.0
3.2
54.18
57.80
ml/min/173m2
0.35
33
207
204
1704
1.27
2.18
5.4
4.5
0.00
0.00
estimate
-0.00
65
545
273
2359
1.24
2.17
5.4
4.7
—
—
—
0
0
43
275
1.60
2.16
1.7
1.6
—
—
—
0
0
23
123
1.90
2.13
1.1
2.1
59.37
61.79
%
0.17
23
123
10
37
2.72
2.07
1.0
1.2
—
—
—
0
0
81
602
1.39
1.97
5.2
3.6
1.22
1.22
mmol/l
0.18
74
514
17
84
2.05
1.97
1.2
1.2
—
—
—
0
0
5
11
4.57
1.94
2.0
2.6
13.60
13.52
%
—
5
11
166
1372
1.27
1.93
5.3
4.8
1.01
1.02
kg/l
0.50
26
207
107
845
1.31
1.77
11.0
8.9
—
—
—
0
0
9
36
2.52
1.74
1.7
1.1
—
—
—
0
0
21
118
1.80
1.71
1.1
1.2
0.91
0.87
nmol/l
0.09
15
97
93
726
1.32
1.68
4.0
3.2
241.87
248.15
ng/l
0.06
84
666
8
32
2.52
1.60
1.1
2.1
—
—
—
0
0
37
249
1.51
1.55
1.2
1.2
—
—
—
0
0
282
2515
1.19
1.54
4.7
5.6
2.31
3.67
ug/l
1.95
255
2204
183
1571
1.22
1.50
2.7
2.4
—
—
—
0
0
40
280
1.45
1.41
2.5
2.9
—
—
—
0
0
75
585
1.31
1.39
3.2
2.4
48.62
31.70
u/l
0.37
66
492
6
24
2.51
1.30
1.2
1.1
—
—
—
0
0
46
338
1.38
1.26
2.0
2.5
—
18.77
—
0
14
9
45
2.01
1.23
1.1
1.1
—
—
—
0
0
9
45
2.01
1.23
1.1
1.1
—
—
—
0
0
11
56
1.98
1.22
2.2
1.4
11.55
14.41
u/l
0.90
11
51
13
71
1.85
1.20
1.2
2.1
—
—
—
0
0
33
232
1.44
1.17
3.8
3.5
0.77
0.87
nmol/l
0.86
25
185
19
118
1.63
1.15
1.3
1.2
—
—
—
0
0
8
39
2.06
1.15
1.0
1.0
—
—
—
0
0
5
21
2.39
1.09
1.0
1.0
—
—
—
0
0
8
41
1.96
1.09
3.6
4.2
—
—
—
0
0
9
46
1.97
1.04
1.1
1.1
—
—
—
0
0
9
46
1.97
1.04
1.1
1.1
—
—
—
0
0
9
46
1.97
1.04
1.1
1.1
—
—
—
0
0
28
196
1.44
1.03
1.3
1.4
—
—
—
0
0
27
189
1.44
1.00
1.3
1.4
298.80
273.26
ug/g
—
10
106
25
173
1.46
0.98
1.4
1.3
—
—
—
0
0
25
173
1.46
0.98
1.4
1.3
—
—
—
0
0
50
391
1.30
0.96
1.6
2.2
11.05
12.19
nmol/l
0.39
41
338
13
77
1.70
0.95
1.9
2.8
—
664.00
—
0
8
12
193
0.62
0.88
1.4
1.7
—
—
—
0
0
14
214
0.65
0.84
1.4
1.8
—
—
—
0
0
31
233
1.34
0.80
1.2
1.3
—
—
—
0
0
221
2023
1.13
0.80
4.0
4.8
23.72
21.73
%
1.14
106
1053
0
25
0.00
0.79
0.0
1.1
—
279.87
—
0
15
7
39
1.80
0.72
1.4
2.3
—
—
—
0
0
7
39
1.80
0.72
1.0
1.4
—
—
—
0
0
7
39
1.80
0.72
1.0
1.4
—
—
—
0
0
14
94
1.50
0.67
1.2
1.3
—
—
—
0
0
24
181
1.34
0.64
1.1
1.2
—
—
—
0
0
22
164
1.35
0.63
1.9
2.3
3.51
3.81
g/l
0.37
16
155
11
71
1.56
0.62
1.5
1.4
—
—
—
0
0
8
50
1.61
0.61
1.4
1.3
—
—
—
0
0
8
50
1.61
0.61
1.4
1.3
—
—
—
0
0
18
131
1.38
0.59
1.9
1.8
—
—
—
0
0
22
286
0.76
0.57
2.6
3.1
31.45
1299.10
u/ml
1.33
22
242
96
853
1.14
0.57
1.3
1.3
32.12
36.54
iu/ml
0.12
29
270
5
88
0.57
0.56
1.2
1.0
—
—
—
0
0
6
37
1.63
0.55
1.0
1.0
—
—
—
0
0
6
38
1.58
0.54
2.0
1.6
—
—
—
0
0
9
61
1.48
0.54
1.2
1.2
—
—
—
0
0
6
40
1.50
0.51
3.5
4.4
—
—
—
0
0
155
1429
1.11
0.51
2.7
3.3
1.09
0.81
ug/l
0.52
107
985
23
180
1.29
0.50
1.1
1.2
—
—
—
0
0
26
207
1.26
0.50
2.5
1.5
—
—
—
0
0
22
172
1.29
0.48
1.4
1.7
16415.31
20318.75
e6/l
0.24
16
122
11
76
1.45
0.48
3.0
4.6
252.17
353.39
umol/l
—
6
67
7
47
1.49
0.47
2.3
2.4
—
—
—
0
0
10
68
1.48
0.47
1.1
1.4
6880.00
156964.83
e6/l
—
5
47
23
183
1.26
0.45
1.5
1.4
—
—
—
0
0
5
31
1.62
0.43
1.0
1.3
—
—
—
0
0
19
149
1.28
0.42
1.3
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
2.2
—
2.43
—
0
6
5
34
1.47
0.40
1.2
1.3
—
—
—
0
0
5
34
1.47
0.40
1.2
1.3
—
—
—
0
0
12
88
1.37
0.40
1.3
1.4
—
—
—
0
0
12
89
1.35
0.38
1.3
1.4
—
—
—
0
0
59
526
1.13
0.37
1.5
1.3
—
—
—
0
0
12
90
1.34
0.36
1.3
1.4
—
—
—
0
0
12
90
1.34
0.36
1.3
1.4
—
—
—
0
0
6
43
1.40
0.35
1.0
1.1
—
—
—
0
0
6
45
1.34
0.34
2.0
1.5
—
—
—
0
0
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
18
217
0.83
0.29
1.1
1.0
—
—
—
0
0
17
139
1.23
0.29
1.5
1.5
—
—
—
0
0
8
65
1.23
0.27
1.6
1.9
—
—
—
0
0
20
236
0.84
0.27
2.4
3.5
202.30
81.32
u/ml
0.28
20
226
12
95
1.27
0.26
1.7
1.5
—
—
—
0
0
12
95
1.27
0.26
1.2
1.3
—
—
—
0
0
9
72
1.25
0.25
1.0
1.0
—
—
—
0
0
9
75
1.20
0.25
1.4
1.5
248.89
305.10
mu/l
—
9
70
9
76
1.19
0.24
1.9
1.5
—
—
—
0
0
9
77
1.17
0.24
1.8
2.9
—
—
—
0
0
13
106
1.23
0.23
1.0
1.1
—
—
—
0
0
5
39
1.28
0.23
2.2
1.5
—
—
—
0
0
82
768
1.08
0.23
3.6
4.0
3.84
24.72
ug/l
1.36
60
655
11
88
1.25
0.22
3.3
3.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
11
89
1.24
0.21
1.3
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
11
90
1.23
0.19
1.3
1.4
—
—
—
0
0
7
58
1.21
0.18
2.0
1.6
—
—
—
0
0
31
281
1.11
0.18
2.7
3.0
3.94
4.38
pmol/l
1.49
24
242
12
101
1.19
0.16
1.7
1.5
—
—
—
0
0
8
70
1.14
0.16
1.1
1.4
—
—
—
0
0
8
70
1.14
0.16
1.1
1.4
—
—
—
0
0
9
79
1.14
0.15
1.7
1.9
—
—
—
0
0
9
79
1.14
0.15
1.9
1.9
161.00
220.83
pmol/l
—
9
72
9
80
1.13
0.15
1.2
1.6
—
—
—
0
0
22
244
0.90
0.15
1.5
1.7
—
—
—
0
0
20
180
1.11
0.13
1.8
2.3
91.61
84.68
ug/min
—
9
108
13
114
1.14
0.12
1.5
1.5
—
—
—
0
0
12
105
1.15
0.11
1.7
1.3
28896.33
99646.19
e6/l
—
6
62
5
45
1.11
0.10
1.2
1.1
—
81.83
—
0
6
6
55
1.09
0.09
1.0
1.1
—
—
—
0
0
18
165
1.09
0.08
1.4
1.5
—
—
—
0
0
5
62
0.81
0.08
1.2
1.7
—
—
—
0
0
7
64
1.09
0.08
1.0
1.6
—
—
—
0
0
7
64
1.09
0.08
1.0
1.6
—
—
—
0
0
7
64
1.09
0.08
1.0
1.6
—
—
—
0
0
22
205
1.08
0.08
1.3
1.7
—
—
—
0
0
12
108
1.11
0.07
1.1
1.5
—
—
—
0
0
12
108
1.11
0.07
1.1
1.5
—
—
—
0
0
10
91
1.10
0.04
1.7
1.5
—
—
—
0
0
10
91
1.10
0.04
1.7
1.5
—
—
—
0
0
153
1513
1.01
0.04
1.8
1.6
1.30
1.29
mmol/l
0.08
138
1232
13
121
1.08
0.03
1.6
1.6
—
—
—
0
0
15
159
0.94
0.03
5.2
4.1
34.01
28.49
mg/l
—
9
104
26
268
0.97
0.02
1.2
1.2
156.55
134.54
iu/ml
0.06
11
95
15
143
1.05
0.01
1.8
2.2
97.00
86.62
%
1.45
15
135
13
136
0.96
0.00
1.2
1.9
2.76
2.52
mg/l
—
8
105
79
796
0.99
0.00
4.6
4.9
36.04
33.10
%
1.25
45
506
13
135
0.96
0.00
1.8
1.6
—
—
—
0
0
16
156
1.03
0.00
1.5
1.5
—
—
—
0
0
15
152
0.99
0.00
1.2
1.3
—
—
—
0
0
62
617
1.01
0.00
1.4
1.4
—
—
—
0
0
11
109
1.01
0.00
4.2
1.8
88.15
89.50
%
0.61
11
109
82
818
1.00
0.00
1.2
1.3
4.81
12.31
u/ml
1.18
33
276
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
8.86
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
67
0.89
-0.00
1.7
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
1.7
1.1
—
—
—
0
0
6
66
0.91
-0.00
1.2
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
0.60
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
11
110
1.00
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PEMPHIGOID_BULL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGOID_BULL | 1.818 [1.56, 2.12] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.081 |
During the follow-up period (1.1.1998 — 31.12.2019), 1650 out of 3117 females with L12_PEMPHIGOID_BULL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGOID_BULL | 1.918 [1.57, 2.35] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 1263 out of 2311 males with L12_PEMPHIGOID_BULL died.
Mortality risk
Mortality risk for people of age
years, who have L12_PEMPHIGOID_BULL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.439% |
| 5 | 0.984% | 2.339% |
| 10 | 2.302% | 6.252% |
| 15 | 4.504% | 11.913% |
| 20 | 7.97% | 19.969% |
Relationships between endpoints
↥Index endpoint: L12_PEMPHIGOID_BULL – Bullous pemphigoid
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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