This is a non-core endpoint: only basic statistics are computed.

Agent resistant to multiple antibiotics

U22_AGENT_RESISTANT_MULTIPLE_ANTIBI

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — U88 Cause of death: ICD-10 — U88 2 out of 7 registries used, show all original rules.	17
4. Check minimum number of events None	17
5. Include endpoints None	17
6. Filter based on genotype QC (FinnGen only)	17

Control definitions (FinnGen only)

Control exclude: U22_BACTERIAL_AGENTS_RESISTANT_ANTIBI

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: U8

NAME	U22_AGENT_RESISTANT_MULTIPLE_ANTIBI
CONTROL_EXCLUDE	U22_BACTERIAL_AGENTS_RESISTANT_ANTIBI
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	U88
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	U88
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Agent resistant to multiple antibiotics based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	97	61	36
Only index persons	96	61	35
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	75.58	66.77
Only index persons	72.72	75.58	67.74

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	17	8	9
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	68.33	71.64	65.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3012095) Magnesium [Moles/volume] in Serum or Plasma

8.76

3.93

12.9

3.5

0.8

mmol/l

—

(1761482) Bacteria [#/volume] in Urine by Culture

14.43

3.82

4.0

4.5

—

(3012544) pH of Venous blood

10.91

3.79

8.7

2.4

—

(3024354) Oxygen [Partial pressure] in Venous blood

9.88

3.60

5.9

2.2

4.3

4.7

kpa

—

(3007853) Bacteria identified in Skin by Aerobe culture

8.39

3.58

11.6

1.5

—

(3023368) Bacteria identified in Blood by Culture

6.73

3.47

9.6

4.6

—

(3021447) Carbon dioxide [Partial pressure] in Venous blood

9.01

3.43

8.7

2.3

6.2

5.6

kpa

—

(3000330) Specific gravity of Urine by Test strip

13.32

3.19

4.4

4.8

—

(3042936) Bacteria identified in Isolate by Culture

6.21

2.92

4.0

1.8

—

(3020779) Urea [Moles/volume] in Serum or Plasma

9.47

2.74

10.2

5.6

9.9

6.9

mmol/l

—

(3026008) Bacteria identified in Urine by Culture

4.89

2.41

9.5

3.5

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

7.31

2.39

3.0

1.2

—

(42870588) Differential panel, method unspecified - Blood

3.75

1.80

20.3

7.4

—

(3044640) Blood type and Crossmatch panel - Blood

3.63

1.77

3.3

2.1

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

4.58

1.75

3.6

3.8

0.1

e6/l

—

(3000494) Fungus identified in Specimen by Culture

4.25

1.65

1.8

2.0

—

(3022948) Iron [Moles/volume] in Serum or Plasma

3.63

1.60

6.2

1.8

9.8

14.8

umol/l

—

(3015736) pH of Urine

3.13

1.52

7.2

5.0

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

3.49

1.39

7.2

1.9

17.2

23.5

—

(3041096) Erythrocytes [Presence] in Urine by Automated

2.87

1.36

6.6

4.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

3.00

1.27

3.0

4.3

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

2.61

1.21

3.0

4.0

2.3

2.4

mmol/l

—

(3002582) Erythrocytes [#/volume] in Urine

2.61

1.21

6.2

2.7

101.7

26.5

e6/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

3.00

1.08

6.0

2.0

3.5

4.2

e6/l

—

(3033658) Prothrombin time (PT) actual/Normal

2.75

1.04

14.5

3.7

96.5

82.5

—

(3026493) Urate [Moles/volume] in Serum or Plasma

2.46

1.04

8.4

3.4

347.6

8830.5

umol/l

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

2.47

0.99

6.1

5.2

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

2.28

0.94

5.7

2.9

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

2.29

0.78

5.6

3.4

18.8

17.8

ng/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

2.29

0.78

6.2

1.8

1.0

1.3

e6/l

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

2.00

0.71

8.4

4.2

—

(3021960) Folate [Moles/volume] in Serum or Plasma

2.02

0.65

3.5

1.4

17.8

24.2

nmol/l

—

(3000850) Epithelial cells [#/volume] in Urine

1.95

0.64

4.2

2.4

2.0

5.5

e6/l

—

(3013512) EKG study

2.00

0.60

4.9

4.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.00

0.43

0.0

7.1

—

(3000492) Spirometry study

0.00

0.42

0.0

1.4

—

(36304419) Bacteria [Presence] in Urine

1.66

0.42

6.8

2.2

—

(3030467) Casts [#/volume] in Urine by Automated count

1.61

0.41

6.8

2.1

0.0

0.3

e6/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

100

1.68

0.36

15.5

4.0

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.22

0.0

2.1

—

(40761535) Cells panel - Urine sediment

0.00

0.22

0.0

5.7

—

(4010399)

0.00

0.22

0.0

1.2

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.00

0.22

0.0

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.22

0.0

1.4

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

0.71

0.22

2.4

6.1

1.6

1.9

ug/l

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

0.00

0.21

0.0

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

1.32

0.21

2.3

2.7

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.21

0.0

1.1

—

(40768804) Tissue Pathology biopsy report

0.73

0.10

4.4

1.8

—

(3044889) 12 lead EKG panel

102

1.22

0.10

4.6

3.9

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.0

1.7

—

1.8

—

(1761868) Lipid panel - Serum or Plasma

1.00

0.00

4.4

3.4

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.0

2.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

4.5

—

0.6

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

4.5

—

1.8

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.00

0.0

5.6

—

1198.6

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.2

—

(40768443) Skin Pathology biopsy report

0.00

0.0

1.0

—

(1002224) Polysomnography panel

0.00

0.0

1.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.4

—

38.4

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.0

6.4

—

94.5

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.0

1.3

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.2

—

(36032269) Testosterone Free [Moles/volume] in Serum or Plasma by calculation

0.00

0.0

1.7

—

155.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint U22_AGENT_RESISTANT_MULTIPLE_ANTIBI and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have U22_AGENT_RESISTANT_MULTIPLE_ANTIBI.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: U22_AGENT_RESISTANT_MULTIPLE_ANTIBI – Agent resistant to multiple antibiotics

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Agent resistant to multiple antibiotics

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints