Melanoma in situ of ear and external auricular canal

CD2_INSITU_MELANOMA_EAR_EXALLC

No definition available.

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data
1. Apply sex-specific rule None	-
2. Check conditions None
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — D03.2& Cause of death: ICD-10 — D03.2& 2 out of 7 registries used, show all original rules.	-
4. Check minimum number of events None	-
5. Include endpoints None	-
6. Filter based on genotype QC (FinnGen only) None	-

Control definitions (FinnGen only)

Control exclude: C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: D03
Name in latin: Melanoma in situ auriculae

NAME	CD2_INSITU_MELANOMA_EAR_EXALLC
CONTROL_EXCLUDE	C3_CANCER\|C3_CANCER_WIDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	D032
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	D032
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Melanoma in situ of ear and external auricular canal based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Melanoma in situ of ear and external auricular canal

Case counts by codes

↥

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	32	15	17
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	70.36	67.31	73.04

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

(ID) Name

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3002256) Pathology report gross observation

27.96

21.04

1.5

1.1

—

(40768804) Tissue Pathology biopsy report

12.64

9.53

4.2

1.6

—

(4035726)

27.91

7.69

1.5

1.0

—

(40768443) Skin Pathology biopsy report

7.78

3.77

1.0

1.3

—

(3022145) Colonoscopy Study observation

5.82

3.42

1.3

1.2

—

(42870588) Differential panel, method unspecified - Blood

3.79

3.34

5.6

6.0

—

(3022096) Basophils/100 leukocytes in Blood

106

3.85

3.26

6.1

6.0

0.7

0.6

0.26

(3019069) Monocytes/100 leukocytes in Blood

108

3.75

3.13

6.1

6.3

9.4

8.7

0.59

101

(3018010) Neutrophils/100 leukocytes in Blood

110

3.64

3.01

6.4

5.8

58.1

58.6

0.06

104

(3019198) Lymphocytes [#/volume] in Blood

123

3.06

2.28

6.4

5.3

1.7

e9/l

0.21

108

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

5.69

2.15

11.2

6.8

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

4.09

1.94

1.3

1.8

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

274

+∞

1.89

10.3

9.4

22.9

24.1

u/l

0.20

262

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

3.74

1.58

12.0

7.4

24.2

26.0

mmol/l

—

(3014007) Fractional oxyhemoglobin in Arterial blood

3.74

1.58

13.0

7.1

92.0

89.1

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

3.50

1.50

12.2

6.6

0.4

0.7

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

3.28

1.41

13.0

6.5

1.3

2.0

—

(3000494) Fungus identified in Specimen by Culture

2.71

1.31

1.3

1.9

—

(3035941) MCH [Entitic mass]

285

+∞

1.24

20.7

20.5

30.6

30.5

0.20

278

(3000963) Hemoglobin [Mass/volume] in Blood

285

+∞

1.24

21.2

20.7

135.9

135.3

g/l

0.08

278

(3024731) MCV [Entitic volume]

284

+∞

1.23

21.1

20.6

91.9

91.5

0.22

277

(3000991) Gas panel - Venous blood

2.77

1.20

13.4

12.1

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

2.14

1.01

1.3

1.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

117

1.97

1.00

1.9

2.2

—

(3021589) Normoblasts [#/volume] in Blood

119

1.91

0.94

10.6

8.5

0.0

e9/l

0.00

(3019225) pH of Specimen

2.22

0.92

3.7

3.8

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.01

0.88

1.4

2.2

—

(40758558) Short blood count panel - Blood

1.84

0.82

4.4

5.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

102

0.49

0.80

2.2

4.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.09

0.74

1.4

1.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.00

0.72

1.4

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

1.74

0.67

1.5

2.1

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

119

1.69

0.66

2.3

2.1

126.0

95.1

pmol/l

—

(3019060) Gas panel - Arterial blood

0.00

0.62

0.0

2.6

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

240

1.80

0.55

3.6

4.6

1.0

1.3

mmol/l

3.24

213

(3015736) pH of Urine

109

0.65

0.48

2.1

3.4

—

(3003396) Base excess in Arterial blood by calculation

1.66

0.44

13.0

4.9

-0.4

2.2

mmol/l

—

(3013512) EKG study

100

1.51

0.42

3.2

4.3

—

(4034850)

0.00

0.42

0.0

9.5

—

(36660697) Celiac disease serology panel - Serum

0.00

0.41

0.0

1.1

—

(36304419) Bacteria [Presence] in Urine

1.39

0.31

2.1

3.2

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

1.39

0.31

5.6

3.3

281.9

22.6

ng/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

0.65

0.30

1.6

4.5

—

(3026008) Bacteria identified in Urine by Culture

101

0.72

0.26

1.9

2.9

—

(3009542) Hematocrit [Volume Fraction] of Blood

220

1.36

0.26

23.0

16.3

41.1

38.7

1.06

129

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

119

1.31

0.23

2.1

4.0

—

(3037467) Urinalysis macro (dipstick) panel - Urine

189

1.32

0.23

3.0

4.6

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

0.00

0.22

0.0

1.2

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

0.00

0.22

0.0

1.5

—

23.8

—

(3022313) Gas panel - Capillary blood

0.00

0.22

0.0

3.8

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.22

0.0

1.1

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.22

0.0

2.4

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.22

0.0

2.4

—

106.4

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.22

0.0

2.4

—

4.1

—

(3018405) Lactate [Moles/volume] in Arterial blood

0.00

0.21

0.0

2.1

—

1.1

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.3

—

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.21

0.0

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.21

0.0

1.7

—

(3018095) Leukocytes [#/volume] in Urine

1.32

0.21

2.4

3.8

5.3

38.7

e6/l

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.21

0.0

2.1

—

(3020891) Body temperature

0.00

0.21

0.0

2.8

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.00

0.21

0.0

1.5

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.20

0.0

5.6

—

(3050449) Albumin [Mass/time] in Urine collected for unspecified duration

0.00

0.20

0.0

1.6

—

114.9

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

254

1.40

0.19

4.1

5.0

1.5

1.4

mmol/l

0.48

227

(3023368) Bacteria identified in Blood by Culture

0.74

0.18

4.8

4.3

—

(1761868) Lipid panel - Serum or Plasma

0.80

0.08

2.0

4.2

—

(3002385) Erythrocyte distribution width [Ratio]

213

1.11

0.02

22.6

17.6

13.3

13.6

0.89

206

(3044889) 12 lead EKG panel

184

1.08

0.01

3.7

4.0

—

(3013707) Erythrocyte sedimentation rate by Westergren method

204

0.95

0.00

3.5

4.8

10.3

12.6

mm/h

0.42

184

(40760892) CBC W Ordered Manual Differential panel - Blood

0.95

0.00

2.6

4.3

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

0.94

0.00

2.3

2.6

30.1

28.1

u/l

—

(3003694) ABO and Rh group [Type] in Blood

0.87

0.00

1.2

1.3

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.0

2.0

—

(40762485) Glomerular basement membrane Ab [Units/volume] in Serum by Immunoassay

0.00

0.0

1.0

—

(3023419) Bacteria identified in Sputum by Culture

0.00

0.0

2.7

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.00

0.0

1.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.0

1.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.7

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.0

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.0

—

(3021584) Pregnancy associated plasma protein A [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

0.0

1.0

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

0.00

0.0

1.6

—

36.1

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

0.0

1.4

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

0.94

0.00

2.1

3.2

—

(40760888) Immunoglobulin light chains.free panel - Serum

0.00

0.0

1.0

—

(44816559) Phosphatidylethanol [Mass/volume] in Blood

0.00

0.0

1.0

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

0.00

0.0

2.3

—

10.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

0.00

0.0

1.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

0.0

2.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.0

1.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

4.0

—

(3021788) Differential panel - Synovial fluid

0.00

0.0

1.0

—

(1616796) Gas panel - Central venous blood

0.00

0.0

2.4

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.0

1.5

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(3037551) Cancer Ag 125 [Units/volume] in Serum or Plasma

0.00

0.0

1.3

—

168.8

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.0

1.4

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.0

1.0

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

1.8

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.0

1.4

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.0

1.3

—

8.1

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

0.0

1.5

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.0

1.0

—

(3023183) Ammonium ion [Moles/volume] in Plasma

0.00

0.0

2.0

—

51.0

—

(3021901) Oxygen saturation in Capillary blood

0.00

0.0

1.7

—

(3004490) Bicarbonate [Moles/volume] standard in Capillary blood

0.00

0.0

4.6

—

23.8

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.0

1.3

—

5.1

—

(3010421) pH of Blood

0.00

0.0

1.5

—

7.4

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: CD2_INSITU_MELANOMA_EAR_EXALLC – Melanoma in situ of ear and external auricular canal

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

FG R12 + FR

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Melanoma in situ of ear and external auricular canal

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Relationships between endpoints