Melanoma in situ

CD2_INSITU_MELANOMA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D03
  • Cause of death: ICD-10 D03

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D00-D09
Name in latin
Melanoma in situ

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7222 3947 3251
Only index persons 6903 3818 3085
Unadjusted period prevalence (%)
Whole population 0.10 0.11 0.09
Only index persons 0.13 0.14 0.12
Median age at first event (years)
Whole population 69.96 68.92 71.19
Only index persons 69.72 68.59 71.11

-FinnGen-

Key figures

All Female Male
Number of individuals 1355 685 670
Unadjusted period prevalence (%) 0.26 0.23 0.30
Median age at first event (years) 69.12 66.85 71.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1179
Matched controls
11789
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D03.5
ICD-10 Finland
Melanoma in situ of trunk
+∞
323.0
374
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
41.3
323.0
497
204
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
36.3
323.0
482
220
D03.31
ICD-10 Finland
Melanoma in situ in another or unspecified part of the face
+∞
323.0
305
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
16.0
256.4
454
443
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
418.1
239.7
233
7
D03.6
ICD-10 Finland
Melanoma in situ of upper limb, including shoulder
+∞
204.2
190
*
8720/2-C44.9
ICD-O-3
Melanoma in situ of skin, NOS
2431.5
203.1
191
*
L57.0
ICD-10 Finland
Actinic keratosis
12.1
203.0
408
492
D03.7
ICD-10 Finland
Melanoma in situ of lower limb, including hip
+∞
185.4
173
*
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
47.9
182.8
223
57
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
20.6
181.3
280
175
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
18.6
179.7
289
202
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
172.2
161
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
165.6
155
*
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
23.9
145.4
212
107
ZZR00
NOMESCO Finland
Flap of skin
106.4
145.2
157
17
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
18.6
142.4
227
149
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
491.3
135.0
132
*
R23.8
ICD-10 Finland
Other and unspecified skin changes
6.3
128.6
400
882
TQW99
NOMESCO Finland
Other minor procedure on skin
13.8
115.5
208
180
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
+∞
113.4
107
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
110.1
104
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
392.0
109.2
108
*
S18
ICPC
Laceration/cut
3.9
106.2
740
3538
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
101.5
96
*
8742/2-C44.9
ICD-O-3
Lentigo maligna of skin, NOS
+∞
97.2
92
*
8720/3-C44.9
ICD-O-3
Malignant melanoma, NOS, of skin, NOS
+∞
91.9
87
*
D03.9
ICD-10 Finland
Melanoma in situ, unspecified
+∞
84.4
80
*
130
Kela drug reimbursment
Malignant tumour
+∞
78.0
74
*
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
28.8
75.4
103
39
D03.4
ICD-10 Finland
Melanoma in situ of scalp and neck
+∞
74.8
71
*
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
18.4
74.3
117
70
115
Kela drug reimbursment
Breast cancer
+∞
71.6
68
*
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
22.1
71.0
105
52
S77
ICPC
Malignant neoplasm of skin
180.1
65.7
68
*
SPAT1153
SPAT
Removal of sutures
3.0
65.0
543
2612
C43.59
ICD-10 Finland
Malignant melanoma of the trunk other or unspecified histology
+∞
64.1
61
*
L82
ICD-10 Finland
Seborrhoeic keratosis
3.8
63.8
321
1057
ZXC50
NOMESCO Finland
Cryotherapy
13.1
61.4
111
93
8720/3-C44.5
ICD-O-3
Malignant melanoma, NOS, of skin of trunk
+∞
59.9
57
*
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
+∞
58.8
56
*
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
+∞
57.8
55
*
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
33.3
57.2
75
24
S82
ICPC
Naevus/mole
4.1
56.3
245
701
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
149.5
54.3
57
*
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
283.4
53.6
54
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
101.6
53.3
58
6
D06BB10
ATC
imiquimod; topical
7.5
52.3
129
189
116
Kela drug reimbursment
Prostate cancer
+∞
51.4
49
*
C43
ICD-10 Finland
Malignant melanoma of skin
+∞
50.4
48
*
WF002
NOMESCO Finland
Radical radiotherapy
181.1
50.3
52
*
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
24.3
48.5
69
30
H02AB02
ATC
dexamethasone; systemic
20.6
48.0
72
37
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
25.8
47.2
66
27
HAC20
NOMESCO Finland
Total mastectomy
+∞
46.1
44
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
46.1
44
*
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
11.1
44.8
87
84
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
44.0
42
*
C43.31
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face originating in lentigo maligna
+∞
44.0
42
*
C43.72
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip: 'superficial spreading' type
+∞
44.0
42
*
C43.62
ICD-10 Finland
Malignant melanoma of upper extremity including shoulder: 'superficial spreading' type
+∞
44.0
42
*
JN4BD
NOMESCO Finland
Extensive body CT
5.6
43.8
135
265
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
65.1
43.5
50
8
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
43.0
41
*
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
+∞
43.0
41
*
ZXC20
NOMESCO Finland
Use of chemical agents
14.7
42.4
72
52
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
10.6
42.2
84
85
A04AA02
ATC
granisetron; systemic, transdermal
116.8
42.0
45
*
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
421.6
41.4
41
*
XQ846
NOMESCO Finland
Digital dermatoscopy and registration of nevi
93.5
41.1
45
5
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
15.3
40.7
68
47
D03.30
ICD-10 Finland
Melanoma in situ on the lip
+∞
39.8
38
*
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
389.4
38.3
38
*
D22
ICD-10 Finland
Melanocytic naevi
6.9
37.2
96
149
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.5
36.6
361
1769
L02BG04
ATC
letrozole; oral
22.6
36.0
52
24
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
11.0
35.7
69
66
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
80.7
35.0
39
5
ZZA00
NOMESCO Finland
Split skin graft
7.7
35.0
83
114
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
34.5
33
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
34.5
33
*
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
8.3
34.3
78
100
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
67.1
34.2
39
6
WF003
NOMESCO Finland
Adjuvant radiotherapy
346.6
34.1
34
*
XX3DW
NOMESCO Finland
Time consuming IT work
4.8
33.9
119
269
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
32.4
31
*
D03.2
ICD-10 Finland
Melanoma in situ of ear and external auricular canal
+∞
32.4
31
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
32.4
31
*
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
31.0
31.8
42
14
C43.51
ICD-10 Finland
Malignant melanoma of the trunk originating in lentigo maligna
+∞
31.4
30
*
ZZA50
NOMESCO Finland
Full thickness skin graft
113.0
30.8
33
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
27.1
30.7
42
16
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
39.2
30.4
38
10
L02AE02
ATC
leuprorelin; implant, parenteral
28.2
30.3
41
15
C43.70
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip without histology
+∞
30.3
29
*
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
+∞
29.3
28
*
L02BB03
ATC
bicalutamide; oral
+∞
29.3
28
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
29.3
28
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
298.9
28.9
29
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
28.3
317
1620
ZQZ00
NOMESCO Finland
Treatment of several skin areas
56.5
28.3
33
6
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
28.2
27
*
8720/3-C44.6
ICD-O-3
Malignant melanoma, NOS, of skin of upper limb and shoulder
+∞
28.2
27
*
ZXC15
NOMESCO Finland
Use of photodynamic technique
14.8
28.1
47
33
S29
ICPC
Skin symptom/complaint other
2.5
27.9
255
1172
DHB00
NOMESCO Finland
Excision of lesion of external nose
36.0
27.5
35
10
8743/3-C44.9
ICD-O-3
Low cumulative sun damage melanoma of skin, NOS
+∞
27.2
26
*
XQ845
NOMESCO Finland
Dermatoscopy
14.0
26.9
46
34
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
28.5
26.8
36
13
XQ848
NOMESCO Finland
Dermatological photography
7.0
26.7
67
100
C43.39
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face other or unspecified histology
+∞
26.1
25
*
8720/3-C44.7
ICD-O-3
Malignant melanoma, NOS, of skin of lower limb and hip
+∞
26.1
25
*
C43.5
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of trunk
266.1
25.8
26
*
HA1AA
NOMESCO Finland
X-ray mammography
6.6
25.5
67
107
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
25.1
24
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
25.1
24
*
C43.30
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face without histology
+∞
25.1
24
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
25.1
24
*
C43.69
ICD-10 Finland
Malignant melanoma of the upper extremity including shoulder other or unspecified histology
+∞
25.1
24
*
C43.60
ICD-10 Finland
Malignant melanoma of the upper extremity including the shoulder without histology
+∞
25.1
24
*
JN4AD
NOMESCO Finland
Body CT examination
5.0
25.1
83
176
WX110
NOMESCO Finland
Local anesthesy
1.9
25.0
777
5893
DAB10
NOMESCO Finland
Partial excision of auricle
+∞
24.0
23
*
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
+∞
24.0
23
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.6
23.8
85
195
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
7.3
23.6
57
81
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
7.5
23.5
56
78
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
23.0
22
*
C43.79
ICD-10 Finland
Malignant melanoma of the lower extremity including hip or other unspecified histology
+∞
23.0
22
*
Y77
ICPC
Malignant neoplasm prostate
234.2
22.7
23
*
L01BC06
ATC
capecitabine; oral
+∞
21.9
21
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
21.9
21
*
D03.1
ICD-10 Finland
Melanoma in situ of eyelid, including canthus
+∞
21.9
21
*
8720/2-C44.5
ICD-O-3
Melanoma in situ of skin of trunk
+∞
21.9
21
*
A03FA01
ATC
metoclopramide; systemic, rectal
2.6
21.6
174
739
QAB10
NOMESCO Finland
Major dressing of wound of skin of head or neck
23.6
21.3
30
13
I78.1
ICD-10 Finland
Naevus, non-neoplastic
6.7
21.3
55
86
D03.8
ICD-10 Finland
Melanoma in situ of other sites
+∞
20.9
20
*
DAB00
NOMESCO Finland
Excision of lesion of auricle
19.9
20.9
31
16
L02BA01
ATC
tamoxifen; oral
78.2
20.7
23
*
C50
ICD-10 Finland
Malignant neoplasm of breast
213.5
20.6
21
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
213.5
20.6
21
*
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
20.5
20.4
30
15
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
8.1
20.4
46
59
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
19.8
19
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
19.8
19
*
D22.4
ICD-10 Finland
Melanocytic naevi of scalp and neck
9.6
19.2
39
42
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
+∞
18.8
18
*
8720/3-C44.3
ICD-O-3
Malignant melanoma, NOS, of skin of other and unspecified parts of face
+∞
18.8
18
*
8090/3-C44.7
ICD-O-3
Basal cell carcinoma, NOS, of skin of lower limb and hip
+∞
18.8
18
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
+∞
18.8
18
*
8097/3-C44.9
ICD-O-3
Basal cell carcinoma, nodular of skin, NOS
+∞
18.8
18
*
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
6.6
18.7
48
75
C43.6
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of upper limb, including shoulder
192.8
18.6
19
*
A98
ICPC
Health maint/preventive medicine
2.8
18.4
1114
10141
NK6AN
NOMESCO Finland
Total body bone isotope imaging
44.7
18.3
22
5
S26
ICPC
Fear of cancer of skin
11.3
18.3
34
31
KE1AT
NOMESCO Finland
Biopsy of prostata with ultrasoudnguidance
5.1
18.2
58
119
C44.91
ICD-10 Finland
Unspecified localization of basocellular carcinoma of the skin
53.4
18.0
21
*
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
+∞
17.7
17
*
C43.53
ICD-10 Finland
Malignant melanoma of the torso nodular
+∞
17.7
17
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
+∞
17.7
17
*
8090/3-C44.4
ICD-O-3
Basal cell carcinoma, NOS, of skin of scalp and neck
+∞
17.7
17
*
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
182.5
17.6
18
*
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
64.3
16.8
19
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
16.8
531
3827
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
+∞
16.7
16
*
KE3AT
NOMESCO Finland
Transrectal gold marker implantation in prostate under ultrasound guidance
+∞
16.7
16
*
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
+∞
16.7
16
*
180
Kela drug reimbursment
Interferon alfa
+∞
16.7
16
*
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
16.7
16
*
C43.99
ICD-10 Finland
Unspecified localization of malignant melanoma of the skin other or unspecified histology
+∞
16.7
16
*
D23.5
ICD-10 Finland
Benign neoplasm: Skin of trunk
6.6
16.4
42
66
J01DB01
ATC
cefalexin; oral
1.8
16.3
921
7832
WX002
NOMESCO Finland
Sedation and analgesia
1.9
16.2
261
1509
Z51.5
ICD-10 Finland
Palliative care
5.0
16.2
52
108
S21
ICPC
Skin texture symptom/complaint
2.2
16.0
178
884
C43.71
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip originating in lentigo maligna
+∞
15.7
15
*
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
15.7
15
*
8742/3-C44.9
ICD-O-3
Lentigo maligna melanoma of skin, NOS
+∞
15.7
15
*
C43.42
ICD-10 Finland
Malignant melanoma of the scalp and neck: 'superficial spreading' type
+∞
15.7
15
*
8090/3-C44.6
ICD-O-3
Basal cell carcinoma, NOS, of skin of upper limb and shoulder
+∞
15.7
15
*
SPAT1141
SPAT
Excision of skin or mucous membrane lesion
3.5
15.4
73
218
L03AA02
ATC
filgrastim; parenteral
38.6
15.4
19
5
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
15.2
210
1140
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
29.0
15.2
20
7
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
45.6
15.1
18
*
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
10.2
15.0
29
29
ZX090
NOMESCO Finland
Other technic of radiotherapy
57.4
14.8
17
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
14.7
987
8662
E0000UV
ATC
NA
1.7
14.7
437
3059
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
18.6
14.7
22
12
KEC00
NOMESCO Finland
Retropubic radical prostatectomy
+∞
14.6
14
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
14.6
14
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
14.6
14
*
C44.11
ICD-10 Finland
Basocellular carcinoma of the skin of the eyelids including the corner of the eye
+∞
14.6
14
*
KEC01
NOMESCO Finland
Percutaneous endoscopic radical prostatectomy
+∞
14.6
14
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
14.6
14
*
8743/3-C44.5
ICD-O-3
Low cumulative sun damage melanoma of skin of trunk
+∞
14.6
14
*
C43.32
ICD-10 Finland
Malignant melanoma of another or unspecified part of the face 'superficial spreading' type
+∞
14.6
14
*
D03.0
ICD-10 Finland
Melanoma in situ of lip
+∞
14.6
14
*
ZX080
NOMESCO Finland
Image guided radiotherapy
151.7
14.5
15
*
C44.3
ICD-10 Finland
Malignant neoplasm: Skin of other and unspecified parts of face
151.7
14.5
15
*
X76
ICPC
Malignant neoplasm breast female
151.7
14.5
15
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
14.4
375
2527
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
2.6
14.3
106
427
A04AA01
ATC
ondansetron; systemic, rectal
5.0
14.1
45
93
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.1
13.8
75
249
QBE15
NOMESCO Finland
Excision of other superficial lesion of skin of trunk
20.3
13.8
20
10
C43.7
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of lower limb, including hip
+∞
13.6
13
*
C43.9
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of skin, unspecified
+∞
13.6
13
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
13.6
13
*
C43.73
ICD-10 Finland
Malignant melanoma of the lower extremity including the hip nodular
+∞
13.6
13
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
13.6
13
*
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
+∞
13.6
13
*
C44.72
ICD-10 Finland
Spinocellular carcinoma of the skin of the lower extremity including the hip
141.5
13.5
14
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
141.5
13.5
14
*
WF004
NOMESCO Finland
Palliative radiotherapy
141.5
13.5
14
*
XKD00
NOMESCO Finland
Uroflowmetry
1.9
13.2
207
1177
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
19.3
12.9
19
10
WZC30
NOMESCO Finland
Teaching
2.3
12.7
127
599
R4110
NOMESCO Finland
Physiotherapy
1.7
12.7
296
1917
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
+∞
12.5
12
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
12.5
12
*
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
+∞
12.5
12
*
A04AD12
ATC
aprepitant; systemic
+∞
12.5
12
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
+∞
12.5
12
*
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
131.3
12.5
13
*
D03
ICD-10 Finland
Melanoma in situ
131.3
12.5
13
*
TQW40
NOMESCO Finland
Remowal of suture of skin
2.6
12.2
90
360
QA4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in face
27.0
12.1
16
6
A79
ICPC
Malignancy NOS
47.1
11.9
14
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
47.1
11.9
14
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
1.9
11.7
173
960
Z48.0
ICD-10 Finland
Attention to surgical dressings and sutures
3.3
11.7
58
181
WX402
NOMESCO Finland
General anaesthesia
2.0
11.6
153
811
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
+∞
11.5
11
*
C79.30
ICD-10 Finland
Secondary malignant tumor of the cerebrum
+∞
11.5
11
*
GDC01
NOMESCO Finland
Thoracoscopic lobectomy of lung
+∞
11.5
11
*
8720/2-C44.6
ICD-O-3
Melanoma in situ of skin of upper limb and shoulder
+∞
11.5
11
*
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
+∞
11.5
11
*
8260/3-C73.9
ICD-O-3
Papillary adenocarcinoma, NOS, of thyroid gland
+∞
11.5
11
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
11.5
11
*
C83.31
ICD-10 Finland
Diffuse lymphoma with large B cells
+∞
11.5
11
*
8500/3-C50.4
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast
+∞
11.5
11
*
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
13.8
11.5
19
14
C90.0
ICD-10 Finland
Multiple myeloma
121.1
11.4
12
*
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
11.4
270
1747
D06BX02
ATC
ingenol mebutate; topical
5.4
11.4
33
62
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.9
11.2
165
912
WX302
NOMESCO Finland
Thoracal epidural anesthesy
4.0
11.1
43
110
C44
ICD-10 Finland
Other malignant neoplasms of skin
43.7
10.9
13
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.8
10.9
187
1093
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
10.8
481
3656
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
21.7
10.7
15
7
JN4CD
NOMESCO Finland
Very extensive body CT
4.5
10.7
37
85
QCE99
NOMESCO Finland
Other excision or repair of lesion of skin of upper limb
14.3
10.5
17
12
C44.50
ICD-10 Finland
Malignant tumor of the skin on the torso without histology
110.9
10.4
11
*
CBB50
NOMESCO Finland
Excision of lesion of eyelid and reconstruction using graft or flap
+∞
10.4
10
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
+∞
10.4
10
*
C50.31
ICD-10 Finland
Malignant tumor of the lower inner quadrant of the mammary gland, ductal tumor
+∞
10.4
10
*
C43.40
ICD-10 Finland
Malignant melanoma of the scalp and neck without histology
+∞
10.4
10
*
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
10.4
10
*
8720/2-C44.7
ICD-O-3
Melanoma in situ of skin of lower limb and hip
+∞
10.4
10
*
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
10.4
10
*
8090/3-C44.1
ICD-O-3
Basal cell carcinoma, NOS, of eyelid
+∞
10.4
10
*
8090/3-C44.2
ICD-O-3
Basal cell carcinoma, NOS, of external ear
+∞
10.4
10
*
S79
ICPC
Neoplasm skin benign/unspecified
4.7
10.3
34
74
ZXC96
NOMESCO Finland
Robot assisted procedure
10.7
10.3
19
18
D04.9
ICD-10 Finland
Carcinoma in situ: Skin, unspecified
19.0
10.3
15
8
S08
ICPC
Skin colour change
2.7
10.2
68
259
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
4.4
10.1
35
81
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
40.4
10.0
12
*
D23.9
ICD-10 Finland
Benign neoplasm: Skin, unspecified
4.1
9.9
37
92
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
12.3
9.9
17
14
B01AB05
ATC
enoxaparin; parenteral
1.6
9.9
321
2253
UKC02
NOMESCO Finland
Cystoscopy
1.8
9.7
187
1133
L02BG03
ATC
anastrozole; oral
55.4
9.7
11
*
R74.8
ICD-10 Finland
Abnormal levels of other serum enzymes
3.1
9.5
51
170
D04.8
ICD-10 Finland
Carcinoma in situ: Skin of other sites
100.8
9.4
10
*
Z08.9
ICD-10 Finland
Follow-up examination after unspecified treatment for malignant neoplasm
30.3
9.4
12
*
C43.91
ICD-10 Finland
Unspecified localization of malignant melanoma of the skin originating in lentigo maligna
+∞
9.4
9
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
9.4
9
*
ZZS00
NOMESCO Finland
Rotation flap
+∞
9.4
9
*
8742/3-C44.3
ICD-O-3
Lentigo maligna melanoma of skin of other and unspecified parts of face
+∞
9.4
9
*
C82.1
ICD-10 Finland
Follicular lymphoma grade II
+∞
9.4
9
*
128
Kela drug reimbursment
Cancers of female genital organs
+∞
9.4
9
*
C43.61
ICD-10 Finland
Malignant melanoma of the upper extremity including the shoulder originating in lentigo maligna
+∞
9.4
9
*
C43.63
ICD-10 Finland
Malignant melanoma of upper extremity including shoulder nodular
+∞
9.4
9
*
Z31.5
ICD-10 Finland
Genetic counselling
3.4
9.4
43
128
TQW80
NOMESCO Finland
Local dermatologic skincare
3.4
9.3
44
134
D23.7
ICD-10 Finland
Benign neoplasm: Skin of lower limb, including hip
7.3
9.2
21
29
QBE00
NOMESCO Finland
Excision of loose skin or fold of skin from trunk
13.8
9.2
15
11
B01AB10
ATC
tinzaparin; parenteral
2.6
9.1
65
257
JN6DR
NOMESCO Finland
PET-CT of whole body metabolism
11.6
9.1
16
14
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
9.1
282
1951
S15
ICPC
Foreign body in skin
2.3
9.0
79
351
WW200
SPAT
NA
0.3
8.8
23
672
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
10.8
8.8
16
15
D23.6
ICD-10 Finland
Benign neoplasm: Skin of upper limb, including shoulder
10.8
8.8
16
15
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
14.1
8.7
14
10
PJA10
NOMESCO Finland
Exploration of lymph nodes
14.1
8.7
14
10
D22.2
ICD-10 Finland
Melanocytic naevi of ear and external auricular canal
50.3
8.7
10
*
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
50.3
8.7
10
*
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
6.2
8.6
22
36
QXB99
NOMESCO Finland
Other procedure to treat skin wound, unspecified location
4.7
8.6
28
61
R31
ICD-10 Finland
Unspecified haematuria
2.0
8.6
113
599
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
16.4
8.6
13
8
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.1
8.5
93
455
XW000
NOMESCO Finland
Bone marrow biopsy
3.0
8.4
46
156
PJD44
NOMESCO Finland
Excision of iliac lymph nodes
90.6
8.4
9
*
J01CA04
ATC
amoxicillin; systemic
1.5
8.4
841
7401
UJF30
NOMESCO Finland
Ileoscopy through colon
2.0
8.4
103
531
ZXA00
NOMESCO Finland
Right side
1.5
8.4
318
2303
153
Kela drug reimbursment
Lenalidomid
+∞
8.3
8
*
C44.40
ICD-10 Finland
Malignant tumor of the skin of the scalp and neck without histology
+∞
8.3
8
*
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
+∞
8.3
8
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
8.3
8
*
C43.29
ICD-10 Finland
Malignant melanoma of the outer ear and in the external ear canal other or unspecified histology
+∞
8.3
8
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
8.3
8
*
K62.7
ICD-10 Finland
Radiation proctitis
+∞
8.3
8
*
L01XE23
ATC
[U] dabrafenib; oral
+∞
8.3
8
*
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
+∞
8.3
8
*
8500/2-C50.9
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of breast, NOS
+∞
8.3
8
*
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
+∞
8.3
8
*
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
+∞
8.3
8
*
C44.99
ICD-10 Finland
Unspecified localization of malignant tumor in skin other or unspecified histology
+∞
8.3
8
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
8.3
8
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
8.3
8
*
C44.10
ICD-10 Finland
Malignant tumor of the skin of the eyelids including the corner of the eye without histology
+∞
8.3
8
*
JN4KR
NOMESCO Finland
Whole body very extensive metabolic PET with CT
17.3
8.1
12
7
QAE99
SPAT
NA
8.5
7.8
16
19
D02AE01
ATC
carbamide; topical
2.2
7.8
79
377
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
2.5
7.7
60
251
JN2CM
NOMESCO Finland
Lower part of abdomen extensive MRI examination with Tesla magnet
45.3
7.7
9
*
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
7.7
251
1748
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.1
7.7
85
421
SPAT1211
SPAT
Application of soft bandage
1.9
7.6
107
580
L03AB05
ATC
interferon alfa-2b; parenteral
18.5
7.6
11
6
QX4AT
NOMESCO Finland
Ultrsound guided needle biopsy of skin
18.5
7.6
11
6
WX320
NOMESCO Finland
Spinalanesthesy
1.5
7.5
261
1847
D48.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Neoplasm of uncertain or unknown behaviour, unspecified
4.5
7.5
25
57
R22.9
ICD-10 Finland
Localized swelling, mass and lump, unspecified
2.2
7.4
70
324
ZXA05
NOMESCO Finland
Left side
1.5
7.4
293
2133
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.8
7.3
132
781
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.3
7.3
68
310
C43.3
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of other and unspecified parts of face
+∞
7.3
7
*
8742/2-C44.5
ICD-O-3
Lentigo maligna of skin of trunk
+∞
7.3
7
*
L04AX04
ATC
lenalidomide; oral
+∞
7.3
7
*
L01AX03
ATC
temozolomide; systemic
+∞
7.3
7
*
C34.32
ICD-10 Finland
Malignant tumor of the lower lobe, bronchus or lung adenocarcinoma
+∞
7.3
7
*
C43.20
ICD-10 Finland
Malignant melanoma of the outer ear and in the external ear canal without histology
+∞
7.3
7
*
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
+∞
7.3
7
*
C77.0
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Lymph nodes of head, face and neck
+∞
7.3
7
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
7.3
7
*
C44.00
ICD-10 Finland
Malignant tumor of the lip skin without histology
+∞
7.3
7
*
8120/3-C67.9
ICD-O-3
Transitional cell carcinoma, NOS, of bladder, NOS
+∞
7.3
7
*
HA013
NOMESCO Finland
Radiotherapy after total ablation of mammary gland
+∞
7.3
7
*
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
+∞
7.3
7
*
1509
Kela drug reimbursment
Dabrafenib (adjuvant treatment)
+∞
7.3
7
*
8720/3-C44.4
ICD-O-3
Malignant melanoma, NOS, of skin of scalp and neck
+∞
7.3
7
*
L02BG06
ATC
exemestane; oral
+∞
7.3
7
*
3024
Kela drug reimbursment
Dabrafenib and trametinib (adjuvant treatment)
+∞
7.3
7
*
8742/2-C44.3
ICD-O-3
Lentigo maligna of skin of other and unspecified parts of face
+∞
7.3
7
*
167
Kela drug reimbursment
Dabrafenib, trametinib and vemurafenib
+∞
7.3
7
*
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
4.5
7.3
24
54
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
15.8
7.2
11
7
R05FA02
ATC
opium derivatives and expectorants; systemic
1.4
7.2
427
3361
TQW40
SPAT
NA
2.8
7.2
43
156
A99
ICPC
Disease/condition unspecnature/site
2.0
7.2
94
499
TKE00
NOMESCO Finland
Needle biopsy of prostate
3.0
7.2
38
128
QA1S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in head
30.2
7.2
9
*
L04AX01
ATC
azathioprine; systemic
2.7
7.1
46
174
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
12.1
7.1
12
10
A02BC02
ATC
pantoprazole; systemic
1.4
7.0
695
5988
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
3.3
6.9
33
103
S19
ICPC
Skin injury other
2.5
6.9
52
216
I10
ICD-10 Finland
Essential (primary) hypertension
1.4
6.9
717
6218
B07.9
ICD-10 Finland
Verruca simplex
3.1
6.9
35
115
JN4JR
NOMESCO Finland
Whole body extensive metabolic PET with CT
16.8
6.7
10
6
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
6.7
943
8617
L57.9
ICD-10 Finland
Skin changes due to chronic exposure to nonionizing radiation, unspecified
22.6
6.7
9
*
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
7.9
6.6
14
18
N02AX02
ATC
tramadol; systemic, rectal
1.4
6.6
445
3571
ZXC12
NOMESCO Finland
Pulse colorlaser
12.3
6.6
11
9
WW500
NOMESCO Finland
Blood transfusion
3.3
6.5
30
92
Z03.1
ICD-10 Finland
Observation for suspected malignant neoplasm
4.5
6.5
21
47
L04AA01
ATC
[U] ciclosporin; systemic
4.5
6.5
21
47
J01FA10
ATC
azithromycin; systemic
1.4
6.5
532
4413
F16
ICPC
Eyelid symptom/complaint
2.3
6.4
57
255
S52
ICPC
Skin, Exc/remov/biopsy/destruc/debrid/caut
70.2
6.4
7
*
YA1BD
NOMESCO Finland
Extensive CT examination of head and neck for dose design of radiotherapy
70.2
6.4
7
*
9823/3-C42.1
ICD-O-3
B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma of bone marrow
70.2
6.4
7
*
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
70.2
6.4
7
*
J05AB11
ATC
valaciclovir; oral
1.7
6.4
129
792
D22.1
ICD-10 Finland
Melanocytic naevi of eyelid, including canthus
14.4
6.4
10
7
HA1CG
NOMESCO Finland
Extensive MRI examination of mammary gland with high intensity magnet
14.4
6.4
10
7
Z02.4
ICD-10 Finland
Examination for driving licence
1.4
6.3
310
2347
M01AH05
ATC
etoricoxib; oral
1.4
6.3
590
4992
PJD41
NOMESCO Finland
Excision of cervical lymph nodes
9.3
6.3
12
13
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
6.3
106
617
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
18.1
6.3
9
5
D22.0
ICD-10 Finland
Melanocytic naevi of lip
18.1
6.3
9
5
WD515
NOMESCO Finland
Demanding therapy of malignancy with enzyme inhibitors and similar treatments
+∞
6.3
6
*
HAE05
NOMESCO Finland
Reconstruction of breast using soft tissue and prosthesis
+∞
6.3
6
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
6.3
6
*
C43.41
ICD-10 Finland
Malignant melanoma of the scalp and neck originating in lentigo maligna
+∞
6.3
6
*
8743/3-C44.7
ICD-O-3
Low cumulative sun damage melanoma of skin of lower limb and hip
+∞
6.3
6
*
8070/3-C44.4
ICD-O-3
Squamous cell carcinoma, NOS, of skin of scalp and neck
+∞
6.3
6
*
WB303
NOMESCO Finland
Simple adjuvant therapy of malignancy with biomodifiers
+∞
6.3
6
*
8720/3-C44.2
ICD-O-3
Malignant melanoma, NOS, of external ear
+∞
6.3
6
*
C43.4
ICD-10 Finland
Malignant neoplasm: Malignant melanoma of scalp and neck
+∞
6.3
6
*
C20.92
ICD-10 Finland
Malignant tumor of the rectum carcinoma of the adenoma
+∞
6.3
6
*
C50.4
ICD-10 Finland
Malignant neoplasm: Upper-outer quadrant of breast
+∞
6.3
6
*
WF001
NOMESCO Finland
Preoperative radiotherapy
+∞
6.3
6
*
C43.82
ICD-10 Finland
Overall malignant melanoma of the skin: 'superficial spreading' type
+∞
6.3
6
*
C43.43
ICD-10 Finland
Malignant melanoma of the scalp and neck nodular
+∞
6.3
6
*
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
+∞
6.3
6
*
8380/3-C54.1
ICD-O-3
Endometrioid adenocarcinoma, NOS, of endometrium
+∞
6.3
6
*
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
26.8
6.2
8
*
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
26.8
6.2
8
*
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.5
6.2
232
1662
G04CA01
ATC
alfuzosin; oral
1.7
6.2
141
896
L08.8
ICD-10 Finland
Other specified local infections of skin and subcutaneous tissue
3.0
6.1
32
108
N63
ICD-10 Finland
Unspecified lump in breast
2.5
6.1
44
180
JFB30
NOMESCO Finland
Right hemicolectomy
8.6
6.1
12
14
127
Kela drug reimbursment
Transplant complication
4.9
6.1
18
37
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.2
6.0
29
92
ZX112
NOMESCO Finland
Subcutaneous
6.7
6.0
14
21
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
4.2
6.0
21
51
D01BA02
ATC
terbinafine; oral; topical
1.4
6.0
272
2024

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
678
772
16.58
307.65
1.9
1.1
—
—
—
0
0
343
314
14.29
307.65
1.5
1.2
—
—
—
0
0
1081
3375
11.89
307.65
4.4
1.7
—
—
—
0
0
206
433
5.43
94.77
1.4
1.2
—
—
—
0
0
519
3059
2.13
37.29
2.6
2.2
—
—
—
0
0
174
635
3.00
35.51
3.8
1.4
4.1
3.7
ug/l
0.23
140
481
565
3562
2.01
32.74
7.0
5.5
—
—
—
0
0
32
26
12.58
32.46
1.3
1.0
—
—
—
0
0
440
2553
2.07
31.96
4.4
3.5
85.7
85.5
%
0.05
427
2481
810
5839
1.96
31.17
10.0
6.3
4.0
4.4
e9/l
6.24
669
5023
48
74
6.69
29.95
1.3
1.1
—
—
—
0
0
729
5146
1.90
29.06
6.5
5.1
1.2
1.2
mmol/l
1.29
654
4536
745
5315
1.89
28.53
6.9
3.7
11.1
12.1
umol/l
2.34
697
4957
1046
8371
2.09
28.34
9.1
5.4
77.7
76.9
u/l
0.21
967
7705
552
3620
1.89
27.08
4.2
2.1
2.3
2.4
mmol/l
0.72
455
2973
678
4763
1.85
26.57
7.5
5.7
0.7
0.7
%
0.05
612
4391
773
5682
1.84
25.88
6.8
5.5
1.2
1.2
mmol/l
0.95
640
4774
750
5484
1.82
25.33
7.3
5.6
0.2
0.2
e9/l
2.77
610
4771
727
5280
1.81
24.97
7.1
5.4
0.6
0.6
e9/l
0.20
586
4510
730
5311
1.81
24.90
7.1
5.4
0.0
0.0
e9/l
0.30
591
4549
686
4900
1.81
24.87
7.4
5.7
2.7
2.9
%
1.71
619
4507
688
4920
1.81
24.84
7.6
5.9
9.1
8.8
%
1.76
623
4549
392
2369
1.92
24.17
2.5
2.2
—
—
—
0
0
735
5402
1.79
23.81
7.1
5.4
1.8
1.8
e9/l
0.48
603
4699
1241
10877
2.68
23.47
18.3
13.9
22.3
24.3
mg/l
1.34
1020
8539
691
5012
1.77
23.19
7.6
5.8
26.7
26.8
%
0.10
625
4608
656
4711
1.76
22.59
4.2
3.7
—
—
—
0
0
505
3364
1.80
22.51
3.9
3.1
56.7
101.1
e6/l
0.86
397
2584
1296
11664
3.55
22.48
13.2
9.4
24.4
24.8
u/l
0.49
1238
11101
926
7356
1.82
22.37
5.0
4.7
2863.2
2636.5
e6/l
0.03
17
111
681
4965
1.75
22.04
7.3
5.6
58.3
58.1
%
0.13
620
4590
567
3929
1.76
21.92
4.6
3.6
93.0
117.2
e6/l
0.41
412
2781
652
4720
1.74
21.44
5.3
3.7
35.4
35.3
g/l
0.35
597
4331
1318
12044
4.45
21.15
27.8
20.6
6.7
6.8
e9/l
1.32
1281
11597
454
2975
1.79
21.09
3.8
3.0
—
—
—
0
0
1317
12038
4.35
20.92
27.8
20.5
243.6
244.1
e9/l
0.12
1283
11643
1317
12041
4.34
20.85
27.7
20.5
91.6
91.6
fl
0.01
1295
11799
1317
12042
4.34
20.83
27.7
20.4
30.4
30.4
pg
0.47
1295
11800
1317
12043
4.34
20.80
27.8
20.5
4.4
4.5
e12/l
0.30
1278
11596
1317
12045
4.33
20.76
27.9
20.7
134.1
135.0
g/l
1.44
1295
11803
647
4703
1.72
20.73
12.5
8.9
0.0
0.0
e9/l
0.16
505
3839
463
3074
1.77
20.43
3.9
3.1
0.5
0.4
e6/l
0.20
359
2328
299
1736
1.93
20.34
3.4
2.8
1.6
2.5
e6/l
1.33
169
946
379
2397
1.81
19.57
3.8
2.7
0.8
0.8
ug/l
0.76
271
1682
42
86
5.01
19.53
1.4
1.5
—
—
—
0
0
486
3305
1.73
19.51
5.4
3.3
7.4
7.4
ph
0.79
105
591
1279
11610
2.81
18.23
22.3
17.1
4.0
4.0
mmol/l
2.90
1247
11267
1275
11581
2.71
17.68
21.8
17.0
139.7
139.7
mmol/l
0.16
1244
11250
377
2462
1.74
17.07
7.4
4.8
—
—
—
0
0
1248
11258
2.37
17.00
5.7
5.5
2.6
2.6
mmol/l
0.04
1110
10215
1226
10986
2.22
16.87
5.0
4.8
4.5
4.5
mmol/l
0.00
1094
10017
195
1042
2.02
16.62
1.4
1.3
—
—
—
0
0
1244
11266
2.27
15.77
17.0
13.6
—
—
—
0
0
1213
10881
2.10
15.74
5.1
4.8
1.5
1.5
mmol/l
1.32
1076
9847
1092
9499
1.77
15.21
21.2
15.6
39.3
39.1
%
0.40
738
6032
628
4776
1.59
15.17
11.1
10.8
1.3
1.4
inr
1.42
187
1368
1155
10220
1.88
15.15
5.7
4.7
1.9
2.1
mu/l
0.97
1023
9192
924
7713
1.62
14.85
4.8
4.4
—
—
—
0
0
339
2226
1.70
14.73
3.1
2.6
575.6
542.8
mosm/kgh2o
2.24
291
1860
27
48
5.72
14.64
2.2
1.6
15.6
13.7
ug/l
0.08
27
37
432
3024
1.63
14.63
2.9
2.5
5185.1
7221.1
umol/l
0.35
362
2557
1178
10519
1.92
14.60
4.5
4.3
1.3
1.3
mmol/l
0.17
1036
9427
296
1883
1.73
14.40
3.3
2.7
0.9
1.5
e6/l
1.38
166
1090
1220
11041
2.05
14.28
5.5
5.0
6.0
6.1
mmol/l
1.99
1074
9903
33
73
4.61
14.04
1.3
1.2
—
—
—
0
0
1179
10576
1.88
13.76
6.6
6.6
39.7
40.7
mmol/mol
3.89
1055
9693
604
4623
1.55
13.74
2.3
2.2
83.4
79.0
nmol/l
3.36
517
4017
977
8333
1.62
13.72
4.7
4.3
12.6
12.8
mm/h
0.14
884
7640
984
8434
1.61
13.27
4.5
3.9
15.1
15.0
pmol/l
0.50
844
7559
213
1262
1.82
13.13
1.4
1.4
—
—
—
0
0
323
2153
1.66
13.05
4.1
2.2
2.5
2.5
mmol/l
0.36
283
1845
561
4286
1.53
12.51
6.2
4.0
5.0
3.0
ug/l
0.51
475
3827
345
2379
1.60
12.03
3.0
2.5
4.1
5.4
e6/l
1.50
309
2064
253
1620
1.69
11.80
3.1
2.5
0.8
0.8
mmol/l
0.59
227
1488
75
313
2.48
11.65
3.7
1.6
31.6
25.6
u/ml
0.28
69
299
87
389
2.32
11.61
2.6
1.9
—
—
—
0
0
112
556
2.11
11.57
2.2
2.1
11.6
14.5
nmol/l
3.37
97
484
479
3597
1.51
11.29
4.1
4.2
—
—
—
0
0
34
92
3.77
11.16
1.7
1.6
—
—
—
0
0
60
230
2.68
11.09
3.6
1.9
1869.9
66.1
u/ml
0.49
51
180
794
6652
1.47
10.51
4.9
4.4
6.6
6.9
mmol/l
3.95
760
6221
171
1013
1.79
10.46
2.9
1.6
65.7
66.9
g/l
1.12
151
904
998
8770
1.52
10.28
24.6
16.8
13.8
13.7
%
1.10
980
8535
43
147
2.99
9.83
1.1
1.3
11.6
10.9
u/l
0.11
35
123
643
5243
1.43
9.42
2.2
2.1
93.1
94.1
pmol/l
0.21
320
2645
175
1076
1.72
9.37
2.6
2.2
7.0
8.5
umol/l
0.63
149
931
161
972
1.74
9.20
3.7
3.6
95.9
92.8
ng/l
0.17
133
825
143
843
1.78
8.87
2.0
1.9
0.2
0.2
g/l
3.49
133
757
410
3106
1.46
8.79
1.6
1.6
21.4
20.5
nmol/l
0.51
327
2579
157
954
1.73
8.76
3.7
1.8
412.0
361.4
nmol/l
1.12
147
856
556
4463
1.42
8.66
3.2
2.8
144.1
131.0
ug/l
0.74
491
4052
149
897
1.74
8.59
2.3
2.1
30.7
36.0
u/l
1.11
127
737
27
76
3.60
8.42
1.1
1.1
—
—
—
0
0
147
887
1.74
8.41
4.6
4.0
—
—
—
0
0
73
354
2.12
8.06
2.8
1.8
22.0
21.3
s
0.55
68
314
250
1753
1.52
7.75
2.5
1.9
30.5
29.9
s
0.74
242
1692
191
1262
1.60
7.70
1.7
1.8
—
—
—
0
0
150
936
1.68
7.58
6.4
3.0
1.2
1.2
mmol/l
0.26
130
791
208
1409
1.56
7.53
2.8
2.1
1.8
1.8
%
0.17
177
1231
78
403
1.99
7.29
2.2
1.4
37.1
37.3
g/l
0.08
62
333
476
3837
1.37
6.80
2.2
2.2
210.2
238.6
u/l
0.25
441
3585
11
9
12.31
6.58
5.3
1.2
—
—
—
0
0
218
1537
1.50
6.52
1.9
2.0
—
—
—
0
0
159
1060
1.57
6.15
2.9
2.2
66.1
68.5
e9/l
0.39
101
824
208
1470
1.49
6.14
7.9
4.8
1.0
1.0
mmol/l
0.12
195
1340
174
1187
1.53
6.07
4.2
3.6
—
—
—
0
0
9
6
15.08
5.90
1.1
1.0
—
—
—
0
0
16
40
4.04
5.90
2.6
1.1
—
—
—
0
0
31
119
2.64
5.83
1.7
1.6
101392.6
79768.2
e6/l
0.12
17
68
29
109
2.70
5.68
1.7
1.6
—
—
—
0
0
32
127
2.56
5.64
1.7
1.6
1643.1
1689.4
e6/l
0.03
20
88
891
8010
1.33
5.64
4.5
4.1
—
—
—
0
0
134
877
1.59
5.61
3.1
1.5
—
—
—
0
0
59
305
1.98
5.56
3.2
3.4
—
—
—
0
0
43
197
2.22
5.55
1.1
1.2
28.4
30.3
iu/l
0.15
35
175
208
1500
1.46
5.52
3.4
2.6
23.3
22.4
%
0.47
191
1259
53
266
2.03
5.43
5.1
2.5
1.9
1.7
mg/l
0.94
48
235
388
3121
1.34
5.37
1.6
1.6
1.3
1.4
mmol/l
0.23
301
2575
383
3079
1.34
5.32
5.4
4.1
—
—
—
0
0
186
2545
0.69
5.27
4.3
4.2
1.0
1.0
kg/l
0.03
28
384
372
2984
1.34
5.23
2.3
2.2
2.8
3.0
mg/l
0.86
296
2517
16
44
3.67
5.21
1.3
1.3
—
—
—
0
0
136
910
1.55
5.18
1.8
1.5
—
—
—
0
0
41
191
2.18
5.10
3.8
3.4
61.2
58.5
%
0.90
41
191
40
185
2.20
5.07
3.4
3.2
4.3
4.4
e9/l
0.09
40
185
207
1516
1.43
5.05
1.4
1.2
—
—
—
0
0
124
818
1.57
5.03
1.9
1.5
—
—
—
0
0
91
560
1.67
4.90
2.2
1.6
1.4
1.5
g/l
0.40
74
478
322
2556
1.34
4.81
1.4
1.3
—
—
—
0
0
67
383
1.79
4.69
5.2
1.5
57.2
46.2
mg/l
0.60
53
307
216
1617
1.40
4.65
3.3
2.5
2.2
2.3
g/l
0.92
199
1494
144
999
1.49
4.65
10.8
6.0
11.8
11.0
mmol/l
0.47
139
940
278
2175
1.35
4.55
5.2
4.3
—
—
—
0
0
66
382
1.77
4.45
5.2
1.5
52.3
49.1
mg/l
0.07
52
307
79
484
1.67
4.35
1.4
1.4
—
—
—
0
0
153
1094
1.45
4.25
1.8
1.6
—
—
—
0
0
132
917
1.49
4.24
7.8
7.4
—
—
—
0
0
104
696
1.54
4.00
3.6
2.3
10.7
10.9
g/l
0.10
96
632
290
2324
1.32
3.99
2.3
1.6
1.9
1.3
mg/l
0.42
220
1798
18
64
2.84
3.96
1.7
1.2
19.2
15.8
ug/l
0.27
18
64
84
537
1.60
3.94
3.3
3.0
4.2
4.5
pmol/l
2.17
73
461
23
94
2.47
3.89
3.6
3.1
—
—
—
0
0
16
55
2.93
3.74
2.3
2.1
0.9
1.2
e9/l
—
10
30
614
5426
1.24
3.73
3.7
3.8
0.0
0.0
estimate
0.00
132
984
15
50
3.02
3.69
1.1
1.1
—
—
—
0
0
227
1777
1.33
3.67
3.2
2.4
12.7
12.7
umol/l
0.02
207
1630
85
555
1.57
3.66
3.8
3.6
24.5
24.3
mmol/l
0.36
79
484
615
5452
1.23
3.58
5.0
5.1
0.0
0.0
estimate
0.50
136
982
425
3620
1.25
3.56
3.2
3.3
—
—
—
0
0
24
106
2.29
3.46
1.8
1.6
—
—
—
0
0
621
5529
1.23
3.42
3.7
3.8
0.0
0.0
estimate
1.08
135
961
10
27
3.72
3.35
1.9
2.3
—
—
—
0
0
20
439
0.45
3.33
2.3
3.7
1.9
1.4
mmol/l
0.73
20
431
402
3425
1.25
3.32
2.9
2.3
58.6
59.4
u/l
0.09
354
3130
92
628
1.50
3.27
1.3
1.3
95.9
60.5
au/ml
—
5
21
21
91
2.33
3.18
2.6
1.9
10.0
10.6
%
0.26
21
91
31
159
1.97
3.11
1.6
1.5
—
—
—
0
0
394
3372
1.24
3.10
3.3
3.3
—
—
—
0
0
59
371
1.62
3.02
3.0
2.4
0.3
0.3
g/l
0.11
24
115
22
101
2.20
2.94
1.0
1.2
—
—
—
0
0
119
872
1.40
2.94
1.7
1.5
—
—
—
0
0
77
519
1.51
2.93
1.3
1.2
—
—
—
0
0
13
46
2.84
2.92
3.2
3.0
—
—
—
0
0
47
283
1.68
2.85
6.0
1.4
—
—
—
0
0
23
110
2.11
2.79
2.8
1.2
—
—
—
0
0
42
247
1.72
2.78
4.1
3.7
—
—
—
0
0
331
2814
1.23
2.73
3.4
3.5
—
—
—
0
0
12
43
2.81
2.65
2.6
2.2
19.2
12.6
%
—
5
21
12
43
2.81
2.65
5.4
1.1
14.2
57.4
u/ml
—
5
11
449
3948
1.21
2.64
3.0
3.0
2419.1
1600.3
ng/l
0.89
383
3394
5
7
7.17
2.55
1.0
1.0
—
—
—
0
0
38
224
1.72
2.52
2.4
1.2
—
—
—
0
0
39
633
0.60
2.52
3.6
2.7
25.5
25.2
mmol/l
0.29
39
610
26
137
1.92
2.46
1.2
1.2
—
—
—
0
0
451
3989
1.20
2.46
3.6
3.2
7.1
7.3
mmol/l
0.28
348
3337
12
45
2.68
2.45
2.8
2.2
70.4
74.0
%
0.22
12
40
27
145
1.88
2.43
2.4
2.8
—
—
—
0
0
38
228
1.69
2.38
1.4
1.8
3.8
4.0
iu/l
—
10
79
478
4261
1.19
2.37
3.3
3.5
—
—
—
0
0
78
555
1.43
2.32
3.0
1.4
1.2
1.2
g/l
0.01
73
501
42
261
1.63
2.32
2.7
2.6
—
—
—
0
0
87
632
1.40
2.31
2.7
2.5
—
—
—
0
0
50
325
1.56
2.30
1.0
1.1
—
—
—
0
0
6
13
4.63
2.27
1.7
1.2
—
—
—
0
0
104
781
1.36
2.26
4.5
3.9
0.0
0.6
%
0.51
29
155
22
404
0.54
2.26
7.7
10.5
—
—
—
0
0
108
818
1.35
2.23
4.5
3.9
0.2
0.1
%
0.67
32
175
220
1836
1.24
2.15
2.0
1.3
2.6
2.7
g/l
0.10
126
1036
7
19
3.70
2.15
1.1
2.6
—
—
—
0
0
281
2405
1.21
2.15
4.2
4.1
212.3
445.0
ng/l
2.06
239
2034
28
159
1.78
2.14
1.2
1.5
—
—
—
0
0
104
789
1.34
2.13
4.1
3.7
0.7
0.6
%
0.12
26
146
9
31
2.92
2.07
1.8
1.7
—
—
—
0
0
5
10
5.01
2.07
7.6
1.1
—
—
—
0
0
7
20
3.51
2.05
5.6
3.5
—
—
—
0
0
30
490
0.60
2.04
3.0
4.4
—
—
—
0
0
16
76
2.12
2.03
1.0
1.2
2.0
2.0
mmol/l
0.14
16
70
79
579
1.39
2.02
7.1
9.4
—
—
—
0
0
436
3903
1.17
2.00
3.7
3.3
371.5
237.0
mg/l
0.24
267
2467
13
57
2.29
1.98
1.1
1.2
—
—
—
0
0
52
354
1.49
1.97
1.6
1.6
—
—
—
0
0
140
1122
1.28
1.95
1.9
2.1
92.7
157.3
ug/g
2.73
96
871
110
856
1.31
1.92
4.5
3.8
0.8
0.8
%
0.03
35
193
0
51
0.00
1.89
0.0
1.2
—
—
—
0
0
295
2567
1.19
1.88
1.8
1.8
1133.7
1177.6
nmol/l
0.29
181
1910
14
65
2.17
1.88
1.8
1.4
0.9
0.9
g/l
0.28
14
65
23
129
1.80
1.86
1.2
1.2
—
—
nmol/l
—
0
0
46
311
1.50
1.82
1.5
1.6
7241.5
14534.0
e6/l
1.13
23
234
14
67
2.10
1.76
1.1
1.6
—
—
—
0
0
18
95
1.91
1.75
1.6
1.4
—
—
—
0
0
17
88
1.94
1.75
2.1
2.0
2.8
3.1
ug/l
0.22
17
81
6
18
3.34
1.74
1.0
1.0
—
—
—
0
0
45
306
1.49
1.74
1.1
1.1
—
—
—
0
0
79
595
1.35
1.74
1.3
1.2
63.9
125.9
iu/ml
1.31
17
240
36
234
1.55
1.72
1.2
1.2
—
—
—
0
0
18
96
1.89
1.71
1.6
1.4
7.2
7.1
g/l
—
10
71
18
96
1.89
1.71
1.6
1.4
2.7
2.9
g/l
—
10
70
18
96
1.89
1.71
1.6
1.4
0.4
0.4
g/l
—
10
70
67
495
1.37
1.67
1.7
2.0
—
—
—
0
0
21
119
1.78
1.66
1.1
1.0
1.5
1.5
g/l
0.62
21
103
7
25
2.81
1.65
1.3
1.3
27.6
27.4
%
—
7
19
20
112
1.80
1.65
1.3
1.3
—
—
—
0
0
211
1809
1.20
1.60
1.3
1.3
28.9
39.2
iu/ml
0.73
52
570
7
27
2.60
1.51
1.7
2.0
—
—
—
0
0
11
51
2.17
1.50
1.4
1.1
—
—
—
0
0
13
65
2.01
1.49
1.2
1.8
—
—
—
0
0
37
251
1.49
1.49
1.1
1.3
14.3
698.0
e6/l
0.97
28
211
37
251
1.49
1.49
1.1
1.3
10.6
39.5
e6/l
0.64
26
202
450
4118
1.14
1.46
4.8
4.0
7.4
8.0
mg/mmol
0.15
263
2583
7
28
2.51
1.45
1.6
1.7
—
—
—
0
0
12
59
2.04
1.43
1.2
1.3
—
—
—
0
0
24
149
1.62
1.41
1.2
1.2
—
—
—
0
0
42
296
1.43
1.41
5.2
4.2
7.4
7.4
ph
0.32
35
242
7
29
2.42
1.39
3.0
2.3
—
—
—
0
0
88
698
1.28
1.39
8.1
8.3
94.5
93.3
%
1.55
88
693
36
248
1.46
1.36
2.4
2.5
15.2
16.5
%
1.27
22
127
14
75
1.88
1.34
3.1
2.5
—
—
—
0
0
41
291
1.42
1.33
1.3
1.4
299.8
301.3
ug/g
0.02
21
167
31
208
1.50
1.33
1.4
1.5
—
—
—
0
0
88
704
1.27
1.31
2.8
3.1
4.0
4.2
e9/l
0.43
52
495
34
234
1.46
1.30
1.5
1.6
—
—
—
0
0
12
62
1.94
1.28
1.1
1.6
—
—
—
0
0
88
707
1.26
1.27
8.1
8.1
1.1
1.4
%
2.64
88
701
87
698
1.26
1.27
8.0
8.2
0.6
0.7
%
0.82
87
692
35
244
1.45
1.26
5.1
4.5
2.0
3.0
mmol/l
0.66
24
163
14
77
1.83
1.25
1.4
1.7
13.0
14.0
umol/l
0.18
14
69
41
299
1.38
1.17
3.2
3.3
0.8
0.8
nmol/l
0.36
34
229
23
150
1.54
1.15
1.9
1.9
0.8
1.1
g/l
0.46
14
119
22
142
1.56
1.14
1.8
1.2
267.4
253.7
u/ml
0.09
12
81
91
746
1.24
1.13
3.5
3.4
7.4
7.4
ph
0.08
16
97
7
30
2.34
1.12
1.0
1.1
—
—
—
0
0
76
611
1.26
1.12
1.2
1.2
122.6
237.0
u/ml
1.08
69
561
20
127
1.58
1.11
1.3
1.3
—
—
—
0
0
5
21
2.39
1.09
1.2
1.0
—
—
—
0
0
5
21
2.39
1.09
1.4
1.1
—
—
—
0
0
8
41
1.96
1.09
16.6
2.8
44.1
65.1
mg/l
—
8
27
19
120
1.59
1.09
1.1
1.2
2.7
7.5
u/ml
—
6
57
37
272
1.37
1.03
2.3
2.1
125.6
132.5
g/l
0.83
30
203
5
22
2.28
1.03
1.2
1.1
—
—
—
0
0
65
804
0.80
1.00
2.2
4.6
—
—
—
0
0
158
1384
1.16
0.98
1.4
1.3
472.2
628.0
titre
0.51
36
322
25
173
1.45
0.98
1.6
1.8
—
—
—
0
0
91
760
1.21
0.97
3.5
3.4
5.2
5.1
kpa
0.19
85
699
86
1029
0.82
0.97
3.8
3.3
—
—
—
0
0
12
69
1.75
0.96
1.3
1.2
12.1
11.0
mmol/l
—
6
19
0
31
0.00
0.96
0.0
2.8
—
141.2
—
0
26
13
77
1.69
0.95
1.1
1.1
—
—
—
0
0
21
141
1.50
0.95
1.5
1.4
35.6
52.0
mu/l
0.35
15
124
28
200
1.41
0.94
7.9
2.9
—
—
—
0
0
67
545
1.24
0.93
3.7
3.5
—
—
—
0
0
6
28
2.15
0.91
1.2
1.2
—
—
—
0
0
501
4724
1.10
0.89
3.5
4.0
36.2
77.5
ng/l
1.66
369
3507
238
2162
1.12
0.87
1.2
1.2
1.3
1.8
u/ml
0.42
68
567
16
104
1.54
0.84
1.1
1.1
0.3
1.1
u/ml
—
7
38
20
137
1.47
0.84
2.0
1.3
103.2
117.9
u/ml
—
5
22
24
331
0.72
0.83
3.7
4.2
—
—
—
0
0
57
462
1.24
0.83
3.9
3.7
25.2
24.7
mmol/l
0.57
50
424
18
121
1.49
0.83
1.2
1.3
—
—
—
0
0
17
114
1.50
0.79
1.0
1.4
274.9
274.9
mosm/kgh2o
0.00
12
82
8
48
1.67
0.78
1.0
1.0
—
7.8
—
0
5
13
82
1.59
0.78
1.0
1.1
3.9
13.7
nmol/l
—
5
16
105
1204
0.86
0.76
1.9
2.5
7.3
7.6
ug/l
0.05
89
1040
9
54
1.67
0.74
1.0
1.0
—
—
—
0
0
5
25
2.00
0.72
1.6
1.1
—
—
—
0
0
29
220
1.33
0.72
1.1
1.4
66.9
64.5
mmol/l
0.07
24
174
11
68
1.62
0.71
1.1
1.2
—
—
—
0
0
11
68
1.62
0.71
2.2
2.8
—
—
—
0
0
9
57
1.58
0.71
1.0
1.1
—
—
—
0
0
84
722
1.17
0.70
1.2
1.3
—
—
—
0
0
29
221
1.32
0.70
2.7
2.6
—
—
—
0
0
19
262
0.72
0.69
1.0
1.1
—
—
—
0
0
5
27
1.85
0.68
1.2
1.7
—
—
—
0
0
52
429
1.22
0.68
1.1
1.1
—
173.4
titre
—
0
12
5
28
1.79
0.66
1.0
2.2
—
—
—
0
0
11
70
1.58
0.65
2.2
2.4
—
—
—
0
0
96
843
1.15
0.63
1.4
1.4
—
—
—
0
0
191
1754
1.10
0.61
37.4
29.3
1.2
1.5
inr
1.17
18
239
0
20
0.00
0.60
0.0
2.9
—
—
—
0
0
133
1198
1.12
0.60
2.4
3.0
215.7
232.4
ng/l
0.17
118
1110
15
105
1.43
0.60
1.1
1.1
—
—
—
0
0
288
2700
1.08
0.59
3.6
3.7
—
—
—
0
0
28
219
1.28
0.58
1.1
1.2
—
—
—
0
0
27
343
0.78
0.58
3.2
2.3
96.8
65.0
ug/min
0.35
21
208
20
149
1.35
0.58
1.5
1.2
—
—
—
0
0
21
158
1.33
0.57
2.1
1.3
—
—
—
0
0
17
124
1.38
0.56
1.9
2.0
—
—
—
0
0
6
37
1.62
0.55
1.0
1.1
—
63.3
ng/l
—
0
7
68
781
0.86
0.54
1.1
1.2
—
—
—
0
0
24
186
1.30
0.54
1.6
2.0
1.4
1.8
mmol/l
2.23
24
181
146
1332
1.11
0.54
6.1
6.5
0.8
1.3
mmol/l
0.85
122
1020
9
61
1.48
0.53
4.0
4.1
—
—
—
0
0
13
91
1.43
0.53
2.8
3.6
—
—
—
0
0
13
91
1.43
0.53
1.1
1.0
1.0
1.0
u/ml
—
6
33
9
133
0.67
0.52
1.8
1.3
—
—
—
0
0
13
92
1.42
0.50
1.0
1.2
—
—
—
0
0
14
101
1.39
0.49
1.2
2.2
3.0
1.8
u/field
—
6
35
49
418
1.18
0.49
1.4
1.5
—
—
—
0
0
317
3006
1.07
0.49
4.3
4.1
0.0
0.0
estimate
0.69
132
950
17
128
1.33
0.47
1.2
1.3
—
66.0
—
0
7
13
94
1.39
0.46
1.2
1.0
3.3
2.6
u/ml
—
7
39
57
651
0.87
0.45
2.9
3.5
—
—
—
0
0
26
211
1.24
0.43
1.5
1.2
—
—
—
0
0
10
140
0.71
0.43
1.9
1.3
—
—
—
0
0
289
2747
1.07
0.42
1.7
1.7
45370797.7
19964540.1
pmol/l
0.24
216
2229
102
1119
0.90
0.42
1.7
1.6
—
—
—
0
0
16
122
1.32
0.42
1.3
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
1.9
—
0
15
46
529
0.86
0.41
1.3
1.4
—
—
—
0
0
11
79
1.40
0.40
1.1
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
9
68
1.33
0.37
4.0
4.0
—
—
—
0
0
13
169
0.77
0.37
2.8
2.2
107.0
105.4
mmol/l
0.65
13
169
13
169
0.77
0.37
2.8
2.2
4.0
4.1
mmol/l
0.21
13
169
11
81
1.36
0.36
1.1
1.1
—
—
—
0
0
5
78
0.64
0.35
1.4
1.3
2.3
1.2
promille
—
5
63
184
1737
1.07
0.35
1.3
1.3
14.1
13.5
u/ml
0.03
51
653
6
44
1.37
0.34
1.3
2.6
—
—
—
0
0
12
91
1.32
0.33
2.0
2.2
—
—
—
0
0
10
74
1.35
0.32
1.1
1.6
—
—
—
0
0
14
110
1.28
0.31
1.1
1.1
—
—
—
0
0
13
164
0.79
0.30
2.8
2.2
—
—
—
0
0
11
142
0.77
0.30
1.7
1.3
—
—
—
0
0
11
142
0.77
0.30
1.7
1.3
—
—
—
0
0
31
268
1.16
0.30
1.5
1.1
—
1816.3
—
0
8
7
55
1.27
0.30
1.1
1.3
—
—
—
0
0
7
55
1.27
0.30
1.1
1.3
—
—
—
0
0
11
141
0.78
0.29
1.7
1.3
—
—
—
0
0
8
109
0.73
0.29
1.9
1.3
—
—
—
0
0
7
57
1.23
0.29
1.1
1.5
—
—
—
0
0
18
149
1.21
0.28
2.3
2.7
—
—
—
0
0
17
142
1.20
0.24
1.0
1.1
—
—
—
0
0
10
78
1.28
0.24
1.0
1.2
—
—
—
0
0
17
143
1.19
0.23
1.0
1.0
—
—
—
0
0
19
162
1.18
0.23
1.9
1.1
—
—
—
0
0
5
39
1.28
0.23
1.2
1.1
861.2
1830.4
miu/ml
—
5
39
5
42
1.19
0.21
5.2
2.2
—
43.0
—
0
19
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
14.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.25
0.20
1.2
1.3
—
—
—
0
0
16
186
0.86
0.19
1.4
1.2
—
—
—
0
0
7
60
1.17
0.17
1.1
1.4
111.6
146.6
nmol/l
—
7
60
14
163
0.86
0.17
1.6
1.5
43.4
65.2
%
—
7
104
51
475
1.08
0.17
1.9
1.7
2.0
1.8
ug/l
0.07
42
410
5
70
0.71
0.16
5.4
1.2
—
—
—
0
0
8
69
1.16
0.16
1.3
1.2
—
—
—
0
0
34
313
1.09
0.15
1.1
1.1
—
—
—
0
0
11
93
1.18
0.14
1.1
1.2
—
—
—
0
0
15
132
1.14
0.13
1.0
1.1
—
21.5
—
0
5
48
509
0.94
0.13
1.6
1.3
—
—
—
0
0
119
1150
1.04
0.13
3.7
3.2
2.0
2.0
mmol/l
0.04
105
918
30
277
1.08
0.13
1.7
2.3
—
—
—
0
0
35
326
1.08
0.12
1.9
1.8
—
—
—
0
0
16
178
0.90
0.11
1.3
1.2
171.8
222.3
miu/ml
—
5
74
47
445
1.06
0.11
1.6
1.5
—
—
—
0
0
10
86
1.16
0.11
1.2
1.2
—
—
—
0
0
8
76
1.05
0.07
1.0
11.2
—
—
—
0
0
11
122
0.90
0.07
1.3
1.7
—
—
—
0
0
23
242
0.95
0.05
1.6
1.6
0.7
0.8
nmol/l
0.16
18
196
11
119
0.92
0.04
2.0
1.5
51.0
28.8
%
—
6
74
21
200
1.05
0.03
1.2
1.5
—
—
—
0
0
27
262
1.03
0.02
4.4
3.6
32.8
28.0
mg/l
0.20
15
171
79
784
1.01
0.00
2.7
3.3
—
—
—
0
0
17
171
0.99
0.00
2.4
2.7
—
—
—
0
0
11
107
1.03
0.00
1.6
1.5
—
—
—
0
0
11
107
1.03
0.00
1.6
1.5
—
—
—
0
0
11
107
1.03
0.00
1.6
1.5
—
—
—
0
0
11
107
1.03
0.00
1.6
1.5
—
—
—
0
0
8
81
0.99
0.00
1.5
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
633.0
—
0
5
0
9
0.00
0.00
0.0
1.6
—
402.8
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
6.8
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint CD2_INSITU_MELANOMA_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
CD2_INSITU_MELANOMA_EXALLC 0.995 [0.86, 1.15] 0.943
Birth year 0.994 [0.99, 1.0] 0.188

During the follow-up period (1.1.1998 — 31.12.2019), 627 out of 3279 females with CD2_INSITU_MELANOMA_EXALLC died.

Males

Parameter HR [95% CI] p-value
CD2_INSITU_MELANOMA_EXALLC 0.946 [0.8, 1.12] 0.508
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 633 out of 2656 males with CD2_INSITU_MELANOMA_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have CD2_INSITU_MELANOMA_EXALLC.

N-year risk Females Males
1 0.07% 0.173%
5 0.517% 0.981%
10 1.435% 2.39%
15 2.698% 4.565%
20 4.845% 7.94%

Relationships between endpoints

Index endpoint: CD2_INSITU_MELANOMA_EXALLC – Melanoma in situ

GWS hits: 7

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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