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Melanoma in situ of ear and external auricular canal

DOID EFO Endpoint Browser

CD2_INSITU_MELANOMA_EAR

melanoma: A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D03.2&
  • Cause of death: ICD-10 — D03.2&

2 out of 7 registries used, show all original rules.

32

4. Check minimum number of events

None

32

5. Include endpoints

None

32

6. Filter based on genotype QC (FinnGen only)

32

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D03
Name in latin
Melanoma in situ auriculae

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 32 15 17
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 70.36 67.31 73.04

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

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OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
20
26
18.85
16.45
1.5
1.3
—
—
—
0
0
25
106
7.17
5.97
4.2
2.2
—
—
—
0
0
8
8
12.79
4.82
1.0
1.5
—
—
—
0
0
16
62
4.16
3.76
2.3
3.9
71.0
84.3
%
1.09
16
62
10
27
4.93
3.68
1.5
1.2
—
—
—
0
0
18
85
3.55
3.04
5.6
6.0
—
—
—
0
0
21
111
3.59
2.95
6.1
6.6
0.7
0.6
%
0.51
21
104
21
114
3.45
2.77
6.1
7.0
9.4
8.5
%
0.71
21
108
21
118
3.27
2.54
6.4
6.5
58.1
58.2
%
0.01
21
113
9
32
3.50
2.21
1.3
1.3
—
—
—
0
0
21
131
2.75
1.91
6.4
6.0
1.7
1.8
e9/l
0.26
15
115
5
16
3.50
1.50
11.2
10.5
—
—
—
0
0
6
26
2.60
1.25
3.7
4.2
—
—
—
0
0
32
285
+∞
1.24
21.2
26.3
135.9
133.1
g/l
0.52
32
280
32
285
+∞
1.24
20.7
26.0
30.6
30.5
pg
0.18
32
280
32
285
+∞
1.24
21.1
26.0
91.9
91.8
fl
0.06
32
280
5
22
2.50
1.07
13.0
11.9
92.0
91.0
%
—
5
22
0
32
0.00
1.01
0.0
3.0
—
—
—
0
0
6
29
2.31
0.95
1.3
1.7
—
—
—
0
0
0
25
0.00
0.83
0.0
2.6
—
24.2
—
0
25
5
23
2.38
0.80
12.2
11.2
0.4
0.7
%
—
5
23
5
24
2.28
0.78
13.0
11.0
1.3
1.9
%
—
5
24
5
25
2.18
0.76
13.4
11.7
—
—
—
0
0
17
127
1.72
0.70
10.6
13.0
0.0
0.0
e9/l
0.50
12
107
16
121
1.64
0.61
2.2
2.2
126.0
88.8
pmol/l
—
7
69
27
240
1.80
0.55
3.6
4.4
1.0
1.2
mmol/l
2.64
27
215
6
91
0.58
0.52
4.8
4.7
—
—
—
0
0
24
208
1.61
0.48
23.0
21.1
41.1
37.8
%
1.60
19
126
0
15
0.00
0.42
0.0
1.2
—
—
—
0
0
0
16
0.00
0.42
0.0
2.8
—
1.5
—
0
16
0
16
0.00
0.42
0.0
2.8
—
8.0
—
0
16
0
16
0.00
0.42
0.0
5.3
—
—
—
0
0
0
17
0.00
0.42
0.0
3.6
—
—
—
0
0
0
17
0.00
0.42
0.0
6.6
—
1.4
—
0
17
13
102
1.46
0.38
3.2
4.3
—
—
—
0
0
12
93
1.46
0.37
1.5
2.1
—
—
—
0
0
8
64
1.33
0.31
5.6
3.4
281.9
22.7
ng/l
—
8
54
27
250
1.51
0.30
4.1
4.9
1.5
1.4
mmol/l
0.35
27
224
5
73
0.63
0.30
1.6
3.9
—
—
—
0
0
21
185
1.39
0.30
3.0
4.6
—
—
—
0
0
9
73
1.32
0.29
4.4
7.5
—
—
—
0
0
8
99
0.74
0.26
1.9
3.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
4.1
—
0
12
0
12
0.00
0.21
0.0
2.7
—
—
—
0
0
0
12
0.00
0.21
0.0
2.7
—
106.5
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
13.6
—
—
—
0
0
5
43
1.19
0.10
13.0
9.5
-0.4
2.4
mmol/l
—
5
34
5
61
0.79
0.09
2.6
5.4
—
—
—
0
0
6
72
0.80
0.08
1.2
1.4
—
—
—
0
0
8
74
1.11
0.08
2.1
3.4
—
—
—
0
0
11
103
1.10
0.02
2.4
3.7
5.3
61.8
e6/l
—
5
76
20
207
0.91
0.02
3.5
5.1
10.3
14.5
mm/h
0.88
20
190
19
184
1.08
0.01
3.7
4.7
—
—
—
0
0
22
216
1.06
0.00
22.6
22.5
13.3
13.9
%
2.03
22
209
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
8.3
—
0
7
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
3.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
6
68
0.86
0.00
2.0
3.7
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
10.4
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
5.1
—
0
7
0
7
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.7
—
15.8
—
0
6

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_INSITU_MELANOMA_EAR – Melanoma in situ of ear and external auricular canal

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).